Aliases for KLB Gene
External Ids for KLB Gene
Previous GeneCards Identifiers for KLB Gene
GeneCards Summary for KLB Gene
KLB (Klotho Beta) is a Protein Coding gene. Diseases associated with KLB include irritable bowel syndrome. Among its related pathways are Signaling by GPCR and Immune System. GO annotations related to this gene include hydrolase activity, hydrolyzing O-glycosyl compounds and fibroblast growth factor binding. An important paralog of this gene is KL.
UniProtKB/Swiss-Prot for KLB Gene
Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity).