Aliases for KLB Gene
External Ids for KLB Gene
Previous GeneCards Identifiers for KLB Gene
GeneCards Summary for KLB Gene
KLB (Klotho Beta) is a Protein Coding gene. Diseases associated with KLB include diarrhea. Among its related pathways are PI-3K cascade and PI-3K cascade. GO annotations related to this gene include fibroblast growth factor binding and hydrolase activity, hydrolyzing O-glycosyl compounds. An important paralog of this gene is GBA3.
UniProtKB/Swiss-Prot for KLB Gene
Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity).