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KLB Gene

protein-coding   GIFtS: 57
GCID: GC04P039408

Klotho Beta

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Klotho Beta1 2     betaKlotho2
BKL2 3 5     Klotho Beta Like2
Klotho Beta-Like Protein2 3     BetaKlotho3
beta-klotho2     EC 3.2.18

External Ids:    HGNC: 155271   Entrez Gene: 1528312   Ensembl: ENSG000001349627   OMIM: 6111355   UniProtKB: Q86Z143   

Export aliases for KLB gene to outside databases

Previous GC identifers: GC04P039232 GC04P039084 GC04P038733


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KLB Gene:
KLB (klotho beta) is a protein-coding gene. Diseases associated with KLB include syndromic diarrhea, and irritable bowel syndrome. GO annotations related to this gene include fibroblast growth factor binding and hydrolase activity, hydrolyzing O-glycosyl compounds. An important paralog of this gene is KL.

UniProtKB/Swiss-Prot: KLOTB_HUMAN, Q86Z14
Function: Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the
rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1
and FGFR4 to bind FGF21 (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_006238.12  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLB gene promoter:
         HOXA9B   HOXA9   CUTL1   Meis-1b   Pax-3   ARP-1   Sox9   TGIF   Meis-1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLB promoter sequence
   Search Chromatin IP Primers for KLB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p14   Ensembl cytogenetic band:  4p14   HGNC cytogenetic band: 4p14

KLB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLB gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P039408:  view genomic region     (about GC identifiers)

Start:
39,408,473 bp from pter      End:
39,453,156 bp from pter
Size:
44,684 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: KLOTB_HUMAN, Q86Z14 (See protein sequence)
Recommended Name: Beta-klotho  
Size: 1044 amino acids; 119808 Da
Subunit: Interacts with FGFR1 and FGFR4 (By similarity). Interacts with FGF19; this interaction is direct.
Interacts (via C-terminus) with FGF21; this interaction is direct
Secondary accessions: Q2M3K8

Explore the universe of human proteins at neXtProt for KLB: NX_Q86Z14

Explore proteomics data for KLB at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn71, Asn120, Asn125, Asn211, Asn308, Asn391, Asn554, Asn611, Asn702, Asn706,
                                 Asn971
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for KLB (Q86Z14)
     GLFYVDF  VKYWITI 


    See KLB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_783864.1  
    ENSEMBL proteins: 
     ENSP00000257408  
    Reactome Protein details: Q86Z14

    KLB Human Recombinant Protein Products:

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    KLB Antibody Products:

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    KLB Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR017853 Glycoside_hydrolase_SF
     IPR001360 Glyco_hydro_1
     IPR013781 Glyco_hydro_catalytic_dom

    Graphical View of Domain Structure for InterPro Entry Q86Z14

    ProtoNet protein and cluster: Q86Z14

    UniProtKB/Swiss-Prot: KLOTB_HUMAN, Q86Z14
    Domain: Contains 2 glycosyl hydrolase 1 regions. However, the first region lacks the essential Glu active site
    residue at position 241, and the second one lacks the essential Glu active site residue at position 889. These
    domains are therefore predicted to be inactive
    Similarity: Belongs to the glycosyl hydrolase 1 family. Klotho subfamily


    KLB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLOTB_HUMAN, Q86Z14
    Function: Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the
    rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1
    and FGFR4 to bind FGF21 (By similarity)

         Enzyme Number (IUBMB): EC 3.2.12

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004553hydrolase activity, hydrolyzing O-glycosyl compounds IEA--
    GO:0005515protein binding IPI19059246
    GO:0017134fibroblast growth factor binding IPI18829467
         
    KLB for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KLB:
     Synthetic lethal with Ras 

         9 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Klb):
     adipose tissue  behavior/neurological  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism 
     limbs/digits/tail  liver/biliary system  no phenotypic analysis  skeleton 

    KLB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for KLB: Klbtm1Yin Klbtm1.2Sakl Klbtm1.1Akha

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KLB
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KLB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KLB

    miRNA
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    miRTarBase miRNAs that target KLB:
    hsa-mir-93-5p (MIRT048903), hsa-mir-34a-5p (MIRT006874)

    Block miRNA regulation of human, mouse, rat KLB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KLB (see all 12):
    hsa-miR-505 hsa-miR-3673 hsa-miR-548am hsa-miR-3166 hsa-miR-1324 hsa-miR-520a-5p hsa-miR-409-5p hsa-miR-525-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KLB

    Gene Editing
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KLOTB_HUMAN, Q86Z14: Cell membrane; Single-pass type III membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    KLB for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KLB About   (see all 10)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PI-3K cascade
    PI3K/AKT activation0.93
    PI3K/AKT Signaling in Cancer0.88
    GAB1 signalosome0.93
    PI3K events in ERBB4 signaling0.88
    Constitutive PI3K/AKT Signaling in Cancer0.88
    Role of LAT2/NTAL/LAB on calcium mobilization0.80
    PIP3 activates AKT signaling0.88
    Signaling by SCF-KIT0.72
    2Signaling by FGFR
    Signaling by FGFR0.91
    DAP12 interactions0.89
    Signaling by FGFR in disease0.91
    Signaling by PDGF0.87
    Downstream signaling of activated FGFR0.91
    Signaling by EGFR0.83
    Downstream signal transduction0.90
    Signaling by EGFR in Cancer0.82
    3Insulin receptor signalling cascade
    Insulin receptor signalling cascade0.94
    IGF1R signaling cascade0.92
    IRS-related events0.94
    IRS-related events triggered by IGF1R0.92
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.92
    PI3K Cascade0.87
    IRS-mediated signalling0.92
    Signaling by Insulin receptor0.80
    4FGFR ligand binding and activation
    FGFR ligand binding and activation0.79
    Negative regulation of FGFR signaling0.56
    SHC-mediated cascade0.79
    Klotho-mediated ligand binding0.00
    FRS2-mediated cascade0.70
    betaKlotho-mediated ligand binding0.00
    5Downstream Signaling Events Of B Cell Receptor (BCR)
    Downstream Signaling Events Of B Cell Receptor (BCR)0.79
    Signaling by the B Cell Receptor (BCR)0.79

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for KLB
        FGF signaling pathway


    Selected Reactome Pathways for KLB (see all 9)
        PI3K Cascade
    betaKlotho-mediated ligand binding
    Phospholipase C-mediated cascade
    FRS2-mediated cascade
    Negative regulation of FGFR signaling



    KLB for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KLB
    Interactions:

        Search GeneGlobe Interaction Network for KLB

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for KLB (Q86Z141, 2, 3 ENSP000002574084) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGF21Q9NSA11, 2, 3, ENSP000002221574EBI-8515198,EBI-3909329 MINT-6799907 MINT-6799922 I2D: score=2 STRING: ENSP00000222157
    FGFR1P113622, 3, ENSP000003802804MINT-6799939 I2D: score=1 STRING: ENSP00000380280
    FGF19ENSP000002943124STRING: ENSP00000294312
    FGFR4ENSP000002924084STRING: ENSP00000292408
    HDAC6ENSP000003340614STRING: ENSP00000334061
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process IEA--
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0008284positive regulation of cell proliferation IEA--
    GO:0008286insulin receptor signaling pathway TAS--
    GO:0008543fibroblast growth factor receptor signaling pathway TAS--

    KLB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLB (KLOTB)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KLB gene: 
    NM_175737.3  

    Unigene Cluster for KLB:

    Klotho beta
    Hs.90756  [show with all ESTs]
    Unigene Representative Sequence: NM_175737
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000257408(uc003gua.3 uc011byj.2)
    miRNA
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    hsa-miR-505 hsa-miR-3673 hsa-miR-548am hsa-miR-3166 hsa-miR-1324 hsa-miR-520a-5p hsa-miR-409-5p hsa-miR-525-5p
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat KLB
      QuantiFast Probe-based Assays in human, mouse, rat KLB

    Additional mRNA sequence: 

    AB079373.1 AK302436.1 BC033021.1 BC104871.1 BC113653.1 BC143575.1 

    1 DOTS entry:

    DT.40114247 

    Selected AceView cDNA sequences (see all 31):

    AI150491 CD251904 AB079373 BX097669 AI733540 NM_175737 AI668605 AA342834 
    CB161552 AI820779 AA918170 H28364 CD246050 CB269613 AI867702 CD300039 
    AW965017 BG720169 BC033021 BX089923 AI968315 AI677905 AA868484 T69664 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KLB expression in normal human tissues (normalized intensities)      KLB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KLB Expression
    About this image


    KLB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Liver (Hepatobiliary System)
             Hepatocyte-like cells
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    KLB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.90756
        Custom PCR Arrays for KLB
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat KLB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KLB gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klb1 , 5 klotho beta1, 5 81.16(n)1
    79.08(a)1
      5 (33.64 cM)5
    833791  NM_031180.21  NP_112457.11 
     653483865 
    chicken
    (Gallus gallus)
    Aves KLB1 klotho beta 71.86(n)
    71.9(a)
      425467  XM_003641245.2  XP_003641293.1 
    lizard
    (Anolis carolinensis)
    Reptilia KLB6
    klotho beta
    62(a)
    1 ↔ 1
    5(72993273-73033823)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.133662 Xenopus laevis transcribed sequence with weak similarity more 72.42(n)    BJ038968.1 
    zebrafish
    (Danio rerio)
    Actinopterygii KLB6
    klotho beta
    45(a)
    1 ↔ 1
    14(741834-749039) ENSDARG00000076294
    fruit fly
    (Drosophila melanogaster)
    Insecta CG97016
    --
    34(a)
    1 → many
    3L(16726646-16732464)
    worm
    (Caenorhabditis elegans)
    Secernentea klo-26
    klo-16
    Protein KLO-1 (klo-1) mRNA, complete cds
    31(a)
    31(a)
    many ↔ many
    many ↔ many
    III(2446223-2448643) WBGene00017103
    IV(7745989-7748225) WBGene00016848


    ENSEMBL Gene Tree for KLB (if available)
    TreeFam Gene Tree for KLB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KLB gene
    KL2  LCTL2  LCT2  GBA32  
    4 SIMAP similar genes for KLB using alignment to 3 protein entries:     KLOTB_HUMAN (see all proteins):
    KL    GBA3    LCT    LCTL

    KLB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KLB (see all 1037)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs76866101,2
    C,F,A--39406490(+) aggctG/Agtctc 1 -- us2k15Minor allele frequency- A:0.50NA WA 10
    rs1862451011,2
    --39406519(+) GATCCA/GGCCGC 1 -- us2k10--------
    rs1901621531,2
    --39406528(+) GCCTCA/GGACTC 1 -- us2k10--------
    rs1828005651,2
    --39406558(+) GGTGCG/TAACCA 1 -- us2k10--------
    rs1874888611,2
    --39406573(+) GCCGGG/TCCTCA 1 -- us2k10--------
    rs1923350871,2
    --39406724(+) ACCAAA/TCTATT 1 -- us2k10--------
    rs1388019881,2
    C--39406776(+) AAAAC-/ATTT  
            
    ATTTA
    1 -- us2k10--------
    rs2016377361,2
    --39406797(+) ATTTA-/TTTATT 1 -- us2k10--------
    rs1836468571,2
    --39406842(+) GGAGTA/GCAGTG 1 -- us2k10--------
    rs1503891271,2
    --39406866(+) TCACTA/GCAGTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KLB (39408473 - 39453156 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for KLB:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665681CNV Deletion23128226
    esv2673187CNV Deletion23128226
    esv274155CNV Insertion20981092
    esv270754CNV Insertion20981092
    nsv878942CNV Loss21882294
    nsv878941CNV Gain21882294
    nsv878940CNV Gain21882294

    Human Gene Mutation Database (HGMD): KLB
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KLB
    DNA2.0 Custom Variant and Variant Library Synthesis for KLB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611135    OMIM disorders: --

    10 diseases for KLB:    About MalaCards
    syndromic diarrhea    irritable bowel syndrome    diarrhea    ovarian cancer
    tonsillitis    hepatocellular carcinoma    thyroiditis    cerebritis
    endotheliitis    prostatitis

    1 disease from the University of Copenhagen DISEASES database for KLB:
    Irritable bowel syndrome

    KLB for disorders           About GeneDecksing

    Genetic Association Database (GAD): KLB
    Human Genome Epidemiology (HuGE) Navigator: KLB (3 documents)

    Export disorders for KLB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KLB gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with KLB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. FGF21 signalling pathway and metabolic traits - genetic association analysis. (PubMed id 20717167)1, 4 Kaess B.M....Tomaszewski M. (Eur. J. Hum. Genet. 2010)
    2. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    3. Different roles of N- and C- termini in the functional activity of FGF21. (PubMed id 19117008)1, 2 Micanovic R.... Kharitonenkov A. (J. Cell. Physiol. 2009)
    4. C-terminal tail of FGF19 determines its specificity toward Klotho co- receptors. (PubMed id 18829467)1, 2 Wu X.... Li Y. (J. Biol. Chem. 2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. I^Klotho suppresses tumor growth in hepatocellular carcinoma by regulating Akt/GSK-3I^/cyclin D1 signaling pathway. (PubMed id 23383245)1 Ye X....Chen G. (PLoS ONE 2013)
    7. Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB. (PubMed id 22442730)1 Yang C....Luo Y. (PLoS ONE 2012)
    8. Pharmacogenetics of the effects of colesevelam on colonic transit in irritable bowel syndrome with diarrhea. (PubMed id 22271411)1 Wong B.S....Zinsmeister A.R. (Dig. Dis. Sci. 2012)
    9. Understanding the physical interactions in the FGF21/FGFR/I^-Klotho complex: structural requirements and implications in FGF21 signaling. (PubMed id 22248288)1 Yie J....Wang M. (amp 2012)
    10. Dynamics and Distribution of KlothoI^ (KLB) and fibroblast growth factor receptor-1 (FGFR1) in living cells reveal the fibroblast growth factor-21 (FGF21)-induced receptor complex. (PubMed id 22523080)1 Ming A.Y....Rocheleau J.V. (J. Biol. Chem. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 152831 HGNC: 15527 AceView: LOC152831 Ensembl:ENSG00000134962 euGenes: HUgn152831
    ECgene: KLB H-InvDB: KLB

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KLB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for KLB gene:
    Search GeneIP for patents involving KLB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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