Aliases for KLB Gene
External Ids for KLB Gene
Previous GeneCards Identifiers for KLB Gene
GeneCards Summary for KLB Gene
KLB (Klotho Beta) is a Protein Coding gene. Among its related pathways are RET signaling and Downstream signaling of activated FGFR2. GO annotations related to this gene include hydrolase activity, hydrolyzing O-glycosyl compounds and fibroblast growth factor binding. An important paralog of this gene is KL.
UniProtKB/Swiss-Prot for KLB Gene
Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity).