KL Gene
protein-coding GIFtS: 65
GCID: GC13P033590
|
|
klotho
| |
Aliases
for KL gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Klotho1 | | KLOTHO5 | | EC 3.2.1.313 8 | | EC 3.2.18 |
Export aliases for KL gene to outside databasesPrevious GC identifers: GC13P031576 GC13P027577 GC13P032526 GC13P031388 GC13P032488 GC13P014401 |
Summaries
for KL gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KL:
This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this proteinhas been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying thedegenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations withinthis protein have been associated with ageing and bone loss. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: KLOT_HUMAN, Q9UEF7Function: May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active siteGlu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in theregulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity).Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity)Function: The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulatinghormone which would extend life span by inhibiting insulin/IGF1 signaling (By similarity)
Gene Wiki entry for KL (Klotho)
|
Genomic Views
for KL gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_024524.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KL gene promoter:
GR PPAR-gamma1 p53 AP-1 GR-alpha PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for KL
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KL |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q12 Ensembl cytogenetic band: 13q13.1 HGNC cytogenetic band: 13q12KL Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13P033590: view genomic region
(about GC identifiers)
Start:
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33,590,207 bp from pter |
End:
|
33,640,282 bp from pter |
Size:
|
50,076 bases |
Orientation:
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plus strand |
|
Proteins
for KL gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KLOT_HUMAN, Q9UEF7 (See
protein sequence)Recommended Name: Klotho precursor Size: 1012 amino acids; 116181 Da
Subunit: Homodimer (By similarity). Interacts with FGF23 and FGFR1 (By similarity)
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein. Note=Isoform 1 shedding leads to asoluble peptide
Subcellular location: Isoform 2: Secreted
Subcellular location: Klotho peptide: Secreted
Miscellaneous: Defects in KL may be a cause of chronic renal failure complications
Secondary accessions: Q5VZ95 Q96KV5 Q96KW5 Q9UEI9 Q9Y4F0Alternative splicing: 2 isoforms: Q9UEF7-1 Q9UEF7-2 (Predominates over the membrane form in all tissues examined)Explore the universe of human proteins at neXtProt for KL: NX_Q9UEF7
Post-translational modifications:
N-glycosylated (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UEF7
4/7 DME Specific Peptides for KL (Q9UEF7) (see all 7)
KL Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004786.2
ENSEMBL proteins: ENSP00000369442 ENSP00000399513 Reactome Protein details: Q9UEF7
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
KL for ontologies About GeneDecksing
KL Antibody Products:
Assay Products for KL: |
Protein
Domains /
Families
for KL gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KL for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UEF7ProtoNet protein and cluster: Q9UEF7 UniProtKB/Swiss-Prot: KLOT_HUMAN, Q9UEF7Domain: Contains 2 glycosyl hydrolase 1 regions. However, the first region lacks the essential Glu active site residueat position 239, and the second one lacks the essential Glu active site residue at position 872Similarity: Belongs to the glycosyl hydrolase 1 family. Klotho subfamily |
Function
for KL gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KLOT_HUMAN, Q9UEF7Function: May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active siteGlu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in theregulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity).Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity)Function: The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulatinghormone which would extend life span by inhibiting insulin/IGF1 signaling (By similarity)Catalytic activity: A beta-D-glucuronoside + H(2)O = D-glucuronate + an alcohol Genatlas biochemistry entry for KL:murine klotho gene homolog,with two spliced variants one secreted predominantly over the membrane form
Enzyme Numbers (IUBMB): EC 3.2.1.311 2 EC 3.2.12
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KL (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KL (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): KL (NM_001648) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KL | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat KL |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KL |
Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds |
-- | -- | | GO:0004566 | beta-glucuronidase activity |
IEA | -- | | GO:0004871 | signal transducer activity |
TAS | 9363890 | | GO:0005104 | fibroblast growth factor receptor binding |
IEA | -- | | GO:0005179 | hormone activity |
IEA | -- |
KL for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for KL: Kltm1Yin Kltm1Lex
15/21 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Kl) (see all 21):
KL for phenotypes About GeneDecksing
|
Pathways & Interactions
for KL gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by FGFR | | | 2 | PIP3 activates AKT signaling | | | 3 | IRS-related events | | | 4 | FGFR2c binds to FGF | | | 5 | Immune System | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/44 
Reactome Pathways for KL (see all 44)
4 
Kegg Pathways (Kegg details for KL):
KL for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KL
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/31 Interacting proteins for KL (Q9UEF73 ENSP000003694424) via UniProtKB, MINT, STRING, and/or I2D (see all 31)About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table
KL for ontologies About GeneDecksing
|
Drugs & Compounds
for KL gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
KL for compounds About GeneDecksing
 Browse Tocris compounds for KL
8 HMDB Compounds for KL About this table
2 Novoseek chemical compound relationships for KL gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| vegf |
21.4 |
3 |
11342433 (2), 10880756 (1) |
| tyrosine |
2.42 |
1 |
10809354 (1) |
Search CenterWatch for drugs/clinical trials and news about KL / KLOT
|
Transcripts
for KL gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KL gene (2 alternative transcripts): NM_004795.3 NM_153683.2 Unigene Cluster for KL: Klotho Hs.524953 [show with all ESTs]Unigene Representative Sequence: NM_0047953 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000487852(uc001uur.1) ENST00000380099(uc001uus.3) ENST00000426690
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KL (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KL (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): KL (NM_001648) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KL | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat KL |
Additional cDNA sequence: AB005142.1 AK097349.1 4 DOTS entries: DT.100743810 DT.414871 DT.99930290 DT.70101635 24/71 AceView cDNA sequences (see all 71): AI261202 BF197501 AA677655 AA885951 BF431196 AI640294 AA913524 AI474763 AA410391 AW615211 AB005142 BF591980 BE221972 AI628577 NM_153683 BE467029 AW772081 AI025650 AA913087 AW779558 AI991430 W31539 AI636622 NM_004795
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for KL About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6 |
|---|
|
| SP1: | | | - | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for KL
|
Expression
for KL gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCTTTCCCT
About this image
See KL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KL
SOURCE GeneReport for Unigene cluster: Hs.524953
UniProtKB/Swiss-Prot: KLOT_HUMAN, Q9UEF7Tissue specificity: Present in cortical renal tubules (at protein level). Soluble peptide is present in serum andcerebrospinal fluid. Expressed in kidney, placenta, small intestine and prostate. Down-regulated in renal cellcarcinomas, hepatocellular carcinomas, and in chronic renal failure kidney
SABiosciences Custom PCR Arrays for KL
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KL
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KL | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KL |
Orthologs
for KL gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for KL gene from 6/20 species (see all 20) About this table
ENSEMBL Gene Tree for KL (if available)
TreeFam Gene Tree for KL (if available) |
Paralogs
for KL gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KL gene
- KLB2 LCTL2 LCT2
2 SIMAP similar genes for KL using alignment to 2 protein entries: KLOT_HUMAN (see all proteins):KLB LCT
KL for paralogs About GeneDecksing
|
Genomic Variants
for KL gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: KLOT_HUMAN, Q9UEF7Polymorphism: Homozygosity for KL-VS allele is associated with decreased longevity and increased cardiovascular diseaserisk
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KL (33590207 - 33640282 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KL: --
Human Gene Mutation Database (HGMD): KL
Locus Specific Mutation Databases (LSDB): KL
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KL |
|
Disorders
/ Diseases
for KL gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KL for disorders About GeneDecksing
OMIM gene information: 604824
OMIM disorders: 211900
UniProtKB/Swiss-Prot: KLOT_HUMAN, Q9UEF7
Defects in KL are a cause of hyperphosphatemic familial tumoral calcinosis (HFTC) [MIM:211900]. A severemetabolic disorder that manifests with hyperphosphatemia and massive calcium deposits in the skin and subcutaneoustissues. Some patients manifest recurrent, transient, painful swellings of the long bones associated with theradiographic findings of periosteal reaction and cortical hyperostosis and absence of skin involvement
20/55  diseases for KL (see all 55): About MalaCardsskin atrophy tumoral calcinosis, hyperphosphatemic hyperphosphatemic familial tumoral calcinosis osteoporosis
familial tumoral calcinosis calcinosis hypophosphatemic rickets and hyperparathyroidism hypervitaminosis d
arteriosclerosis arterial occlusive disease hypophosphatemia secondary hyperparathyroidism
hyperparathyroidism rickets spondylosis priapism
sickle cell disease pulmonary emphysema hyperostosis primary hyperparathyroidism
10 diseases from the University of Copenhagen DISEASES database for KL:Hyperphosphatemia Hypophosphatemia Skin atrophy Hypervitaminosis D
Kidney disease X-linked hypophosphatemia Calcinosis Osteomalacia
Hyperparathyroidism Osteoporosis 1 Novoseek disease relationship for KL gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tumors |
0 |
1 |
10809354 (1) |
Genetic Association Database (GAD): KL
Human Genome Epidemiology (HuGE) Navigator: KL (602 documents)
Export disorders for KL gene to outside databases
|
Publications
for KL gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KL gene, integrated from 9 sources (see all 149):
(articles sorted by number of sources associating them with KL) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Association between a functional variant of the KLOTHO gene and high- density lipoprotein cholesterol, blood pressure, stroke, and longevity. (PubMed id 15677572)1, 2, 4 Arking D.E.... Dietz H.C. (2005)
- Association of human aging with a functional variant of klotho. (PubMed id 11792841)1, 2, 4 Arking D.E.... Dietz H.C. (2002)
- Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein. (PubMed id 9464267)1, 2, 3 Matsumura Y....Nabeshima Y. (1998)
- A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis. (PubMed id 17710231)1, 2, 9 Ichikawa S....Econs M.J. (2007)
- Klotho gene polymorphisms are associated with osteocalcin levels but not bone density of aged postmenopausal women. (PubMed id 16151675)1, 4, 9 Mullin B.H....Prince R.L. (2005)
- KLOTHO genotype and cognitive ability in childhood and old age in the same individuals. (PubMed id 15763166)1, 4 Deary I.J....Whalley L.J. (2005)
- Aging syndrome genes and premature coronary artery disease. (PubMed id 16262891)1, 4 Low A.F....MacRae C.A. (2005)
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
- Secreted Klotho protein in sera and CSF: implication for post- translational cleavage in release of Klotho protein from cell membrane. (PubMed id 15135068)1, 2 Imura A.... Nabeshima Y. (2004)
- Association of klotho gene polymorphism with bone density and spondylosis of the lumbar spine in postmenopausal women. (PubMed id 12110410)1, 4 Ogata N....Kawaguchi H. (2002)
|
External Searches for KL gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KL gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KL gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KL gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KL | Pharmacogenomics, SNPs, Pathways | | Protein Spotlight | http://web.expasy.org/spotlight/back_issues/sptlt065.shtml |
|
| | |
About This Section
| Patent Information for KL gene:
Search GeneIP for patents involving KL
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KL gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KL | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KL | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KL | | | OriGene Protein Over-expression Lysate for KL | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KL | | OriGene 3'-UTR Clone for KL | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KL | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KL | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for KL | | OriGene Custom Protein Services for KL | | | OriGene Custom Immunoassay Development | | |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KL | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KL | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KL | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KL |
| |
 |  |  |  | |
| | | | Search Tocris compounds for KL |
| |  |  |  |  | | | | | | Recombinant Protein for KL |
|
 |
 |
 |
 | | | KL Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KL |
|  |  |  | | | | ThermoFisher Antibodies for KL |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat KL |
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