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Aliases for KIZ Gene

Aliases for KIZ Gene

  • Kizuna Centrosomal Protein 2 3
  • Polo-Like Kinase 1 Substrate 1 2 3 4
  • NCRNA00153 3 4
  • C20orf19 3 4
  • PLK1S1 3 4
  • Chromosome 20 Open Reading Frame 19 2
  • Non-Protein Coding RNA 153 2
  • Centrosomal Protein Kizuna 3
  • Kizuna 3
  • HT013 3
  • RP69 3

External Ids for KIZ Gene

Previous HGNC Symbols for KIZ Gene

  • NCRNA00153
  • C20orf19
  • PLK1S1

Previous GeneCards Identifiers for KIZ Gene

  • GC20P021107

Summaries for KIZ Gene

Entrez Gene Summary for KIZ Gene

  • The protein encoded by this gene localizes to centrosomes, strengthening and stabilizing the pericentriolar region prior to spindle formation. The encoded protein usually remains with the mother centrosome after centrosomal duplication. Sevral transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

GeneCards Summary for KIZ Gene

KIZ (Kizuna Centrosomal Protein) is a Protein Coding gene. Diseases associated with KIZ include retinitis pigmentosa 69 and retinitis pigmentosa. Among its related pathways are PLK1 signaling events.

UniProtKB/Swiss-Prot for KIZ Gene

  • Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIZ Gene

Genomics for KIZ Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KIZ Gene

Start:
21,125,983 bp from pter
End:
21,246,622 bp from pter
Size:
120,640 bases
Orientation:
Plus strand

Genomic View for KIZ Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIZ Gene

No data available for Regulatory Elements for KIZ Gene

Proteins for KIZ Gene

  • Protein details for KIZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2M2Z5-KIZ_HUMAN
    Recommended name:
    Centrosomal protein kizuna
    Protein Accession:
    Q2M2Z5
    Secondary Accessions:
    • B4DDE9
    • B4DK54
    • Q4G0M8
    • Q4G0S5
    • Q5BKY3
    • Q6P0M6
    • Q71ME0
    • Q9NZ35

    Protein attributes for KIZ Gene

    Size:
    673 amino acids
    Molecular mass:
    75111 Da
    Quaternary structure:
    • Interacts with AKAP9, CEP72, ODF2, PCNT and TUBGCP2.
    Miscellaneous:
    • Kizuna means bonds in Japanese
    SequenceCaution:
    • Sequence=AAF67652.1; Type=Frameshift; Positions=283; Evidence={ECO:0000305}; Sequence=AAH39296.1; Type=Frameshift; Positions=279; Evidence={ECO:0000305}; Sequence=AAP97689.1; Type=Frameshift; Positions=198; Evidence={ECO:0000305}; Sequence=BAG59066.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for KIZ Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIZ Gene

Proteomics data for KIZ Gene at MOPED

Post-translational modifications for KIZ Gene

  • Phosphorylation at Thr-379 by PLK1 is not needed for centrosomal localization or pericentriolar material expansion but is indispensable for spindle-pole stabilization.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KIZ Gene

Domains for KIZ Gene

Protein Domains for KIZ Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q2M2Z5

UniProtKB/Swiss-Prot:

KIZ_HUMAN :
  • Q2M2Z5
Family:
  • Belongs to the kizuna family.
genes like me logo Genes that share domains with KIZ: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for KIZ Gene

Function for KIZ Gene

Molecular function for KIZ Gene

UniProtKB/Swiss-Prot Function: Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.

Gene Ontology (GO) - Molecular Function for KIZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16980960
GO:0019901 protein kinase binding IPI 16980960
genes like me logo Genes that share ontologies with KIZ: view

Phenotypes for KIZ Gene

genes like me logo Genes that share phenotypes with KIZ: view

Animal Models for KIZ Gene

MGI Knock Outs for KIZ:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIZ

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for KIZ Gene

Localization for KIZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIZ Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes to centrosomes throughout the cell cycle. After centrosome duplication, it usually remains associated only with the mother centrosome, containing the older mature centriole and particles surrounding it. During prophase, additional particles accumulate around both separating centrosomes. Does not accumulate at the microtubule minus ends, but instead localizes to the centrosomes and centrosome-surrounding area in a microtubule-independent and dependent manner, respectively. {ECO:0000269 PubMed:24680887}.

Gene Ontology (GO) - Cellular Components for KIZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 16980960
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with KIZ: view

No data available for Subcellular locations from COMPARTMENTS for KIZ Gene

Pathways for KIZ Gene

SuperPathways for KIZ Gene

Superpath Contained pathways
1 PLK1 signaling events
genes like me logo Genes that share pathways with KIZ: view

Pathways by source for KIZ Gene

1 BioSystems pathway for KIZ Gene

Interacting Proteins for KIZ Gene

Gene Ontology (GO) - Biological Process for KIZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007051 spindle organization IMP 16980960
genes like me logo Genes that share ontologies with KIZ: view

Transcripts for KIZ Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIZ

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KIZ
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIZ Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13
SP1: -
SP2: - -
SP3:
SP4: - -

Relevant External Links for KIZ Gene

GeneLoc Exon Structure for
KIZ
ECgene alternative splicing isoforms for
KIZ

Expression for KIZ Gene

mRNA expression in normal human tissues for KIZ Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for KIZ Gene

genes like me logo Genes that share expressions with KIZ: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KIZ Gene

Orthologs for KIZ Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIZ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLK1S1 35
  • 99.16 (n)
  • 98.37 (a)
cow
(Bos Taurus)
Mammalia PLK1S1 35
  • 81.46 (n)
  • 69.49 (a)
dog
(Canis familiaris)
Mammalia PLK1S1 35
  • 84.77 (n)
  • 73.6 (a)
mouse
(Mus musculus)
Mammalia Plk1s1 35
  • 81.72 (n)
  • 70.51 (a)
Plk1s1 16
rat
(Rattus norvegicus)
Mammalia Plk1s1 35
  • 81.09 (n)
  • 68.93 (a)
chicken
(Gallus gallus)
Aves PLK1S1 35
  • 53.41 (n)
  • 41.59 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10588 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17566 35
Species with no ortholog for KIZ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KIZ Gene

ENSEMBL:
Gene Tree for KIZ (if available)
TreeFam:
Gene Tree for KIZ (if available)

Paralogs for KIZ Gene

No data available for Paralogs for KIZ Gene

Variants for KIZ Gene

Sequence variations from dbSNP and Humsavar for KIZ Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs721785 -- 21,159,530(-) gggac(C/T)gaagg intron-variant
rs765585 -- 21,190,532(+) ATTGC(C/T)TCGGG intron-variant
rs765586 -- 21,190,498(+) CACTA(G/T)AGATT intron-variant
rs910803 -- 21,243,433(+) CTGGC(C/T)GTGAG intron-variant
rs910975 -- 21,175,529(+) GCAGG(A/G)GTTAG intron-variant

Relevant External Links for KIZ Gene

HapMap Linkage Disequilibrium report
KIZ
Human Gene Mutation Database (HGMD)
KIZ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KIZ Gene

Disorders for KIZ Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for KIZ Gene including...

Search for KIZ Gene in MalaCards »

UniProtKB/Swiss-Prot

KIZ_HUMAN
  • Retinitis pigmentosa 69 (RP69) [MIM:615780]: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. {ECO:0000269 PubMed:24680887}. Note=The disease is caused by mutations affecting the gene represented in this entry.
genes like me logo Genes that share disorders with KIZ: view

Publications for KIZ Gene

  1. The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarity. (PMID: 16980960) Oshimori N. … Yamamoto T. (Nat. Cell Biol. 2006) 2 3 4
  2. Cep72 regulates the localization of key centrosomal proteins and proper bipolar spindle formation. (PMID: 19536135) Oshimori N. … Yamamoto T. (EMBO J. 2009) 3 4
  3. Whole-exome sequencing identifies KIZ as a ciliary gene associated with autosomal-recessive rod-cone dystrophy. (PMID: 24680887) El Shamieh S. … Audo I. (Am. J. Hum. Genet. 2014) 3 4
  4. Lupus nephritis susceptibility loci in women with systemic lupus erythematosus. (PMID: 24925725) Chung S.A. … Langefeld C.D. (J. Am. Soc. Nephrol. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for KIZ Gene

Sources for KIZ Gene

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