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KIT Gene

protein-coding   GIFtS: 76
GCID: GC04P055524

V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog

(Previous name: piebald trait)
(Previous symbol: PBT)
  See KIT-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog1 2 3     C-Kit2
PBT1 2 3 5     CD1172
Piebald Trait Protein2 3     Mast/Stem Cell Growth Factor Receptor Kit2
Proto-Oncogene C-Kit2 3     Proto-Oncogene Tyrosine-Protein Kinase Kit2
Tyrosine-Protein Kinase Kit2 3     Soluble KIT Variant 12
SCFR2 3     V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene-Like Protein2
P145 C-Kit2 3     CD117 Antigen3
EC 2.7.10.13 8     EC 2.7.108
Piebald Trait1     

External Ids:    HGNC: 63421   Entrez Gene: 38152   Ensembl: ENSG000001574047   OMIM: 1649205   UniProtKB: P107213   

Export aliases for KIT gene to outside databases

Previous GC identifers: GC04P055328 GC04P055485 GC04P055439 GC04P055365 GC04P055218 GC04P051471


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KIT Gene:
This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular
homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast
cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal
stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for KIT Gene:
KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) is a protein-coding gene. Diseases associated with KIT include sarcoma, and mastocytosis. GO annotations related to this gene include protein homodimerization activity and protease binding. An important paralog of this gene is FLT4.

UniProtKB/Swiss-Prot: KIT_HUMAN, P10721
Function: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an
essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance,
gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF
binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates
the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase.
Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or
MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads
to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT
signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor.
Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the
transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform
Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1

Gene Wiki entry for KIT (CD117) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_022853.16  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KIT gene promoter:
         Max1   p53   GCNF   RelA   AREB6   MEF-2A   GCNF-1   STAT3   GCNF-2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKIT promoter sequence
   Search Chromatin IP Primers for KIT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KIT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q12   Ensembl cytogenetic band:  4q12   HGNC cytogenetic band: 4q12

KIT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIT gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P055524:  view genomic region     (about GC identifiers)

Start:
55,524,085 bp from pter      End:
55,606,881 bp from pter
Size:
82,797 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KIT_HUMAN, P10721 (See protein sequence)
Recommended Name: Mast/stem cell growth factor receptor Kit precursor  
Size: 976 amino acids; 109865 Da
Subunit: Monomer in the absence of bound KITLG/SCF. Homodimer in the presence of bound KITLG/SCF, forming a
heterotetramer with two KITLG/SCF molecules. Interacts (via phosphorylated tyrosine residues) with the adapter
proteins GRB2 and GRB7 (via SH2 domain), and SH2B2/APS. Interacts (via C-terminus) with MPDZ (via the tenth PDZ
domain). Interacts (via phosphorylated tyrosine residues) with PIK3R1 and PIK3 catalytic subunit. Interacts (via
phosphorylated tyrosine) with CRK (isoform Crk-II), FYN, SHC1 and MATK/CHK (via SH2 domain). Interacts with LYN
and FES/FPS. Interacts (via phosphorylated tyrosine residues) with the protein phosphatases PTPN6/SHP-1 (via SH2
domain), PTPN11/SHP-2 (via SH2 domain) and PTPRU. Interacts with PLCG1. Interacts with DOK1 and TEC
Miscellaneous: Numerous proteins are phosphorylated in response to KIT signaling, but it is not evident to
determine which are directly phosphorylated by KIT under in vivo conditions
Selected PDB 3D structures from and Proteopedia for KIT (see all 14):
1PKG (3D)        1QZJ (3D)        1QZK (3D)        1R01 (3D)        1T45 (3D)        1T46 (3D)    
Secondary accessions: B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99
Alternative splicing: 3 isoforms:  P10721-1   P10721-2   P10721-3   

Explore the universe of human proteins at neXtProt for KIT: NX_P10721

Explore proteomics data for KIT at MOPED

Post-translational modifications: 

  • Ubiquitinated by SOCS6. KIT is rapidly ubiquitinated after autophosphorylation induced by KITLG/SCF binding,
    leading to internalization and degradation1
  • Autophosphorylated on tyrosine residues. KITLG/SCF binding enhances autophosphorylation. Isoform 1 shows low
    levels of tyrosine phosphorylation in the absence of added KITLG/SCF (in vitro). Kinase activity is
    down-regulated by phosphorylation on serine residues by protein kinase C family members. Phosphorylation at
    Tyr-568 is required for interaction with PTPN11/SHP-2, CRK (isoform Crk-II) and members of the SRC
    tyrosine-protein kinase family. Phosphorylation at Tyr-570 is required for interaction with PTPN6/SHP-1.
    Phosphorylation at Tyr-703, Tyr-823 and Tyr-936 is important for interaction with GRB2. Phosphorylation at
    Tyr-721 is important for interaction with PIK3R1. Phosphorylation at Tyr-823 and Tyr-936 is important for
    interaction with GRB71
  • Glycosylation2 at Asn130, Asn145, Asn283, Asn293, Asn300, Asn320, Asn352, Asn367, Asn463, Asn486
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for KIT (P10721) (see all 40)
     EGGTYTF  ALYKNLL  RDLAARN  VAVKMLK 


    See KIT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000213.1  NP_001087241.1  

    ENSEMBL proteins: 
     ENSP00000390987   ENSP00000288135  
    Reactome Protein details: P10721

    KIT Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant KIT Protein
    R&D Systems Recombinant & Natural Proteins for KIT (CD117/c-kit)
    Enzo Life Sciences proteins for KIT
    OriGene Purified Protein for KIT
    OriGene Protein Over-expression Lysate for KIT
    OriGene Custom MassSpec
    OriGene Custom Protein Services for KIT
    GenScript Custom Purified and Recombinant Proteins Services for KIT
    Novus Biologicals KIT Proteins
    Novus Biologicals KIT Lysates
    Sino Biological Recombinant Protein for KIT
    Sino Biological Cell Lysate for KIT
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for KIT 

    KIT Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of KIT
    R&D Systems Antibodies for KIT (CD117/c-kit)
    Cell Signaling Technology (CST) Antibodies for KIT 
    OriGene Antibodies for KIT
    OriGene Custom Antibody Services for KIT
    Novus Biologicals KIT Antibodies
    Abcam antibodies for KIT
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for KIT
    LSBio Antibodies in human, mouse, rat for KIT

    KIT Assay Products:

    EMD Millipore Kits and Assays for the Analysis of KIT
    OriGene Custom Assay Services for KIT
    R&D Systems ELISAs for KIT (CD117/c-kit)         (see all)
    GenScript KIT-Activity-based Kinase Assay for Compound Screening
    Cell Signaling Technology (CST) Sandwich ELISA Kits for KIT
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for KIT 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
    PDGF (platelet-derived growth factor) receptor family
    PDGF (platelet-derived growth factor) receptor family

    Selected InterPro protein domains (see all 14):
     IPR003598 Ig_sub2
     IPR007110 Ig-like_dom
     IPR017441 Protein_kinase_ATP_BS
     IPR016243 Tyr_kinase_CSF1/PDGF_rcpt
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P10721

    ProtoNet protein and cluster: P10721

    3 Blocks protein domains:
    IPB001824 Receptor tyrosine kinase
    IPB003598 Immunoglobulin C-2 type
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: KIT_HUMAN, P10721
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily
    Similarity: Contains 5 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with KIT           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KIT_HUMAN, P10721
    Function: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an
    essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance,
    gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF
    binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates
    the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase.
    Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or
    MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads
    to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT
    signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor.
    Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the
    transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform
    Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Present in an inactive conformation in the absence of bound ligand. KITLG/SCF binding leads to
    dimerization and activation by autophosphorylation on tyrosine residues. Activity is down-regulated by
    PRKCA-mediated phosphorylation on serine residues. Inhibited by imatinib/STI-571 (Gleevec) and sunitinib; these
    compounds maintain the kinase in an inactive conformation
    Induction: Up-regulated by cis-retinoic acid in neuroblastoma cell lines

         Genatlas biochemistry entry for KIT:
    Hardy-Zuckerman 4 feline sarcoma viral (v-kit or c-kit) oncogene homolog,homologous to murine dominant
    spotting,involved in melanogenesis

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IEA--
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity TAS1717985
    GO:0004714transmembrane receptor protein tyrosine kinase activity IDA--
    GO:0004716receptor signaling protein tyrosine kinase activity IEA--
         
    Find genes that share ontologies with KIT           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for KIT:
     Decreased substrate adherent c  Decreased viability in HMC1.1   Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

         Selected MGI mutant phenotypes (inferred from 107 alleles(MGI details for Kit) (see all 27):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  integument  limbs/digits/tail  liver/biliary system 

    Find genes that share phenotypes with KIT           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KIT
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KIT

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KIT
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KIT

    miRNA
    Products:
        
    miRTarBase miRNAs that target KIT:
    hsa-mir-181c-5p (MIRT047222), hsa-mir-221-3p (MIRT001780), hsa-mir-186-5p (MIRT021165), hsa-mir-335-5p (MIRT017735), hsa-mir-146b-5p (MIRT005371), hsa-mir-222-3p (MIRT001779)

    Block miRNA regulation of human, mouse, rat KIT using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KIT (see all 62):
    hsa-miR-142-5p hsa-miR-193a-3p hsa-miR-4272 hsa-miR-4305 hsa-miR-301a hsa-miR-759 hsa-miR-519a hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidKIT 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for KIT
    Predesigned siRNA for gene silencing in human, mouse, rat KIT

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KIT

    Clone
    Products:
         
    OriGene clones in human, mouse for KIT (see all 16)
    OriGene ORF clones in mouse, rat for KIT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): KIT (NM_000222)
    Sino Biological Human cDNA Clone for KIT
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KIT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIT

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KIT
    Browse ESI BIO Cell Lines and PureStem Progenitors for KIT 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIT

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11506 VA4-11328 VF1-11505) for KIT 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KIT_HUMAN, P10721: Isoform 1: Cell membrane; Single-pass type I membrane protein
    KIT_HUMAN, P10721: Isoform 2: Cell membrane; Single-pass type I membrane protein
    KIT_HUMAN, P10721: Isoform 3: Cytoplasm. Note=Detected in the cytoplasm of spermatozoa, especially in the
    equatorial and subacrosomal region of the sperm head
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular4
    nucleus4
    cytosol3
    cytoskeleton2
    endoplasmic reticulum2
    golgi apparatus1
    lysosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0005615extracellular space IDA14625290
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane TAS--

    Find genes that share ontologies with KIT           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KIT About   (see all 35)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    Endothelin-1 Signaling Pathway0.46
    Cytokine-cytokine receptor interaction0.43
    2Kit Receptor Signaling Pathway
    Signaling events mediated by Stem cell factor receptor (c-Kit)0.37
    Kit Receptor Signaling Pathway0.37
    3PI-3K cascade
    PI3K/AKT activation0.93
    PI3K events in ERBB4 signaling0.88
    GAB1 signalosome0.93
    Role of LAT2/NTAL/LAB on calcium mobilization0.80
    Constitutive PI3K/AKT Signaling in Cancer0.88
    Signaling by SCF-KIT0.72
    PIP3 activates AKT signaling0.88
    Signaling by ERBB40.66
    4Signaling by FGFR
    Signaling by FGFR0.91
    DAP12 interactions0.89
    Signaling by FGFR in disease0.91
    Signaling by PDGF0.87
    Downstream signaling of activated FGFR0.91
    Signaling by EGFR0.83
    Downstream signal transduction0.90
    Signaling by EGFR in Cancer0.82
    5Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    PPAR Pathway0.66
    Cellular Apoptosis Pathway0.85
    Rac1 Pathway0.65
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61


    Find genes that share SuperPaths with KIT           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for KIT (see all 50)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    2 Cell Signaling Technology (CST) Pathways for KIT
        Lymphocyte Signaling
    Tyrosine Kinases / Adaptors

    1 GeneGo (Thomson Reuters) Pathway for KIT
        Development EPO-induced MAPK pathway

    4 BioSystems Pathways for KIT
        Cardiac Progenitor Differentiation
    Kit Receptor Signaling Pathway
    C-MYB transcription factor network
    Signaling events mediated by Stem cell factor receptor (c-Kit)


    4 Reactome Pathways for KIT
        Constitutive PI3K/AKT Signaling in Cancer
    Regulation of KIT signaling
    Signaling by SCF-KIT
    PIP3 activates AKT signaling

    2 PharmGKB Pathways for KIT
        Imatinib Pathway, Pharmacokinetics/Pharmacodynamics
    Sorafenib Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for KIT) (see all 9):
        Ras signaling pathway
    Rap1 signaling pathway
    Cytokine-cytokine receptor interaction
    Endocytosis
    PI3K-Akt signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including KIT (see all 8): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Lung Cancer in human mouse rat
              Cancer Drug Targets in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Embryonic Stem Cells in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for KIT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KIT (P107211, 2, 3 ENSP000002881354) via UniProtKB, MINT, STRING, and/or I2D (see all 123)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629931, 2, 3, ENSP000003390074EBI-1379503,EBI-401755 MINT-8028852 MINT-8030385 I2D: score=6 STRING: ENSP00000339007
    PIK3R2O004592, 3, ENSP000002222544MINT-8037279 I2D: score=5 STRING: ENSP00000222254
    PLCG1P191742, 3, ENSP000002440074MINT-8028837 I2D: score=4 STRING: ENSP00000244007
    CRKP461082, 3, ENSP000003005744MINT-8030415 I2D: score=3 STRING: ENSP00000300574
    GRB7Q144512, 3, ENSP000003107714MINT-8028863 I2D: score=3 STRING: ENSP00000310771
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 78):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity IDA--
    GO:0001541ovarian follicle development ISS--
    GO:0002318myeloid progenitor cell differentiation IEA--
    GO:0002320lymphoid progenitor cell differentiation IEA--
    GO:0002327immature B cell differentiation ISS--

    Find genes that share ontologies with KIT           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for KIT
      Browse compounds at ApexBio 

    Browse Tocris compounds for KIT

    2 HMDB Compounds for KIT    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    10 DrugBank Compounds for KIT    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    SunitinibSU011248 (see all 2)557795-19-4targetantagonist17367763 12873999 11752352 17545799 12748309 14753710
    ImatinibCGP-57148B (see all 4)152459-95-5targetantagonist multitarget17369583 17559139 16865565 16087693 17458563
    Sorafenib-- 284461-73-0targetantagonist17272980 17545544 17178882 17102120 17229632
    Dasatinib-- 302962-49-8targetantagonist16397263 16434489 17351742
    Adenosine-5'-Diphosphate-- 20398-34-9target--17139284 17016423
    Phosphonotyrosine-- 21820-51-9target--17139284 17016423
    NilotinibAMN-107 (see all 2)641571-10-0targetantagonist17699867
    PazopanibGW-786034 (see all 2)444731-52-6targetinhibitor17288876
    Ponatinib -- 943319-70-8targetinhibitor23539538
    Regorafenib-- 755037-03-7targetinhibitor--

    1 IUPHAR Ligand for KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog)    About this table
    LigandTypeActionAffinityPubmed IDs
    stem cell factor
    NoneNone--

    Selected Novoseek inferred chemical compound relationships for KIT gene (see all 85)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    imatinib 96.2 1022 17546049 (7), 20043176 (6), 17545544 (5), 14645423 (5) (see all 99)
    tyrosine 89.2 979 16287490 (7), 9528781 (5), 12600228 (4), 17949810 (4) (see all 99)
    sunitinib 85.9 51 19390946 (3), 17208434 (2), 20095048 (2), 17367763 (2) (see all 40)
    dasatinib 80.1 33 16397263 (5), 16434489 (3), 19671763 (2), 20145167 (2) (see all 21)
    pkc 412 74.3 12 15972446 (2), 15790786 (2), 16189265 (2), 19026036 (1) (see all 9)
    tandutinib 65.6 12 15304388 (4), 15242881 (3), 16902153 (1)
    sorafenib 64.4 27 17545544 (8), 20109071 (2), 17178882 (1), 20372153 (1) (see all 16)
    ag-1296 61.1 7 7954456 (1), 12512837 (1), 17654122 (1)
    su5416 60.5 10 11222388 (3), 17169805 (1), 11600818 (1), 15355900 (1) (see all 8)
    su6668 58.8 5 11222388 (3), 16144927 (1), 12888313 (1)

    1 PharmGKB related drug/compound annotation for KIT gene    About this table
    Drug/compound PharmGKB Annotation
    imatinib



    Find genes that share compounds with KIT           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for KIT gene (2 alternative transcripts): 
    NM_000222.2  NM_001093772.1  

    Unigene Cluster for KIT:

    V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
    Hs.479754  [show with all ESTs]
    Unigene Representative Sequence: NM_000222
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000412167(uc010igt.2) ENST00000288135(uc010igr.3 uc010igs.3)
    ENST00000514582 ENST00000512959
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KIT using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KIT (see all 62):
    hsa-miR-142-5p hsa-miR-193a-3p hsa-miR-4272 hsa-miR-4305 hsa-miR-301a hsa-miR-759 hsa-miR-519a hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidKIT 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for KIT
    Predesigned siRNA for gene silencing in human, mouse, rat KIT
    Clone
    Products:
         
    OriGene clones in human, mouse for KIT (see all 16)
    OriGene ORF clones in mouse, rat for KIT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): KIT (NM_000222)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KIT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIT
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for KIT
    OriGene qSTAR qPCR primer pairs in human, mouse for KIT
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KIT
      QuantiTect SYBR Green Assays in human, mouse, rat KIT
      QuantiFast Probe-based Assays in human, mouse, rat KIT
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11506 VA4-11328 VF1-11505) for KIT 

    Additional mRNA sequence: 

    AJ438313.1 AK304031.1 BC071593.1 EU826594.1 GU983671.1 HM015525.1 HM015526.1 HM030712.1 
    HM030713.1 HM437240.1 X06182.1 

    1 DOTS entry:

    DT.115605 

    Selected AceView cDNA sequences (see all 95):

    AW468784 AA552932 AW073559 BX955809 BM713257 AI890068 AI567693 AI308810 
    AW244098 AU100291 AW949528 AI567686 AU108050 AI143554 AJ438313 AA481776 
    AI696267 BC071593 AA873164 AW264522 AI355325 AI674108 BX642234 BM971784 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KIT (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b ^
    SP1:              -                                                                                                     -                                   -   
    SP2:                                                                                                                    -                                       
    SP3:                                                                                                                                                            
    SP4:                                                                          -                                                                                 
    SP5:                                                                                                                                                            

    ExUns: 18 ^ 19 ^ 20 ^ 21
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for KIT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    KIT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTCCTTGAA
    KIT Expression
    About this image


    KIT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 34) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 24 entries
             Macrophage-Dendritic cell progenitors Hematopoietic Bone Marrow
             Angiogenic cell precursor
             Hematopoietic progenitor cells
     
     Ovary (Reproductive System)    fully expand to see all 9 entries
             Theca Cells Antral Follicle
             Ovigerous Cord
             Oocytes
             ovary ; follicle cells   
     
     Gonad
             Oogonia Ovigerous Cord
             Fetal Gonadal Stromal Cell
             Germ-like cells
     
     Heart (Cardiovascular System)    fully expand to see all 8 entries
             Cardiac progenitor cells (c-kit+)
     
     Melanocytes (Integumentary System)    fully expand to see all 4 entries
             Melanocytes-like cells
             Human EpiDermal Melanocytes-dark (HEM-dark)   
    KIT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KIT Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.479754

    UniProtKB/Swiss-Prot: KIT_HUMAN, P10721
    Tissue specificity: Isoform 1 and isoform 2 are detected in spermatogonia and Leydig cells. Isoform 3 is detected
    in round spermatids, elongating spermatids and spermatozoa (at protein level). Widely expressed. Detected in the
    hematopoietic system, the gastrointestinal system, in melanocytes and in germ cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including KIT (see all 8): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Lung Cancer in human mouse rat
              Cancer Drug Targets in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Embryonic Stem Cells in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for KIT
    OriGene qSTAR qPCR primer pairs in human, mouse for KIT
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KIT
    QuantiTect SYBR Green Assays in human, mouse, rat KIT
    QuantiFast Probe-based Assays in human, mouse, rat KIT
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KIT gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kit1 , 5 kit oncogene1, 5 82.89(n)1
    82.96(a)1
      5 (39.55 cM)5
    165901  NM_001122733.11  NP_001116205.11 
     755749165 
    chicken
    (Gallus gallus)
    Aves KIT1 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene more 69.57(n)
    67.05(a)
      378783  NM_204361.1  NP_989692.1 
    lizard
    (Anolis carolinensis)
    Reptilia KIT6
    v-kit Hardy-Zuckerman 4 feline sarcoma viral oncog...
    65(a)
    1 ↔ 1
    5(104401434-104457107)
    African clawed frog
    (Xenopus laevis)
    Amphibia kit-A2 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene more 75.09(n)    Z48770.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AF153446.12   -- 74.67(n)   30256  AF153446.1 


    ENSEMBL Gene Tree for KIT (if available)
    TreeFam Gene Tree for KIT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for KIT gene
    FLT42  FGFR42  PDGFRB2  CSF1R2  FGFR32  PDGFRA2  RET2  KDR2  
    FGFR12  FGFR22  FLT32  FLT12  
    Selected SIMAP similar genes for KIT using alignment to 10 protein entries:     KIT_HUMAN (see all proteins) (see all similar genes):
    kit    FLT1    NIN/PDGFRB fusion    CSF1R    FLT4    FLT3
    RET    RET/PTC2    CCDC6-RETa    CCDC6-RETc    FGFR2    FGFR3
    R11    R12    EPHA2    FGFR4    IGF1R    CD74/ROS fusion

    Find genes that share paralogs with KIT           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KIT (see all 1834)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs289333711,2,,4
    CPiebald trait (PBT)4 pathogenic155496048(+) GGAGTG/TTCCCA 4 C F mis1 ese30--------
    rs289339691,2,4
    A testicular tumor4--see VAR_0331342 mis40--------
    VAR_0420254
    A colorectal adenocarcinoma sample4--see VAR_0420252 D N mis40--------
    VAR_0331304
    Piebald trait (PBT)4--see VAR_0331302 G R mis40--------
    rs289339681,2,4
    Gastrointestinal stromal tumor (GIST)4--see VAR_0331232 mis40--------
    VAR_0041084
    Piebald trait (PBT)4--see VAR_0041082 G V mis40--------
    VAR_0238284
    Acute myeloid leukemia4--see VAR_0238282 D Y mis40--------
    VAR_0041094
    Mast cell leukemia4--see VAR_0041092 D V mis40--------
    VAR_0238304
    A germ cell tumor of the testis4--see VAR_0238302 A P mis40--------
    VAR_0331374
    Piebald trait (PBT)4--see VAR_0331372 T P mis40--------

    HapMap Linkage Disequilibrium report for KIT (55524085 - 55606881 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for KIT:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2727617CNV Deletion23290073
    esv2727619CNV Deletion23290073
    dgv144n6CNV Loss16902084
    nsv526344CNV Gain19592680
    esv275029CNV Gain+Loss21479260
    esv275209CNV Gain+Loss21479260

    Human Gene Mutation Database (HGMD): KIT
    Selected Site Specific Mutation Identification with PCR Assays for KIT (see all 51):
    Cosmic IdAA Change
    1251p.V559I
    1294p.D579del
    22379p.D820H
    1290p.L576P
    1257p.V560D
    Selected Site Specific Cancer Mutation PCR Panels containing KIT (see all 14):
    Hematopoietic Neoplasms
    Ovarian Cancer
    Cancer Comprehensive Panel 384HT
    KIT Pathway
    Oncogene Panel 384HT
    2 Copy Number PCR Panels containing KIT:
    Oncogenes & Tumor Suppressor Genes 384HC
    Lung Cancer
    SeqTarget long-range PCR primers for resequencing KIT
    DNA2.0 Custom Variant and Variant Library Synthesis for KIT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 164920   
    OMIM disorders: 172800  606764  154800  601626  273300  
    UniProtKB/Swiss-Prot: KIT_HUMAN, P10721
  • Piebald trait (PBT) [MIM:172800]: Autosomal dominant genetic developmental abnormality of pigmentation
    characterized by congenital patches of white skin and hair that lack melanocytes. Note=The disease is caused by
    mutations affecting the gene represented in this entry
  • Gastrointestinal stromal tumor (GIST) [MIM:606764]: Common mesenchymal neoplasms arising in the
    gastrointestinal tract, most often in the stomach. They are histologically, immunohistochemically, and
    genetically different from typical leiomyomas, leiomyosarcomas, and schwannomas. Most GISTs are composed of a
    fairly uniform population of spindle-shaped cells. Some tumors are dominated by epithelioid cells or contain a
    mixture of spindle and epithelioid morphologies. Primary GISTs in the gastrointestinal tract commonly metastasize
    in the omentum and mesenteries, often as multiple nodules. However, primary tumors may also occur outside of the
    gastrointestinal tract, in other intra-abdominal locations, especially in the omentum and mesentery. Note=The
    gene represented in this entry is involved in disease pathogenesis
  • Testicular germ cell tumor (TGCT) [MIM:273300]: A common malignancy in males representing 95% of all
    testicular neoplasms. TGCTs have various pathologic subtypes including: unclassified intratubular germ cell
    neoplasia, seminoma (including cases with syncytiotrophoblastic cells), spermatocytic seminoma, embryonal
    carcinoma, yolk sac tumor, choriocarcinoma, and teratoma. Note=The gene represented in this entry may be involved
    in disease pathogenesis
  • Leukemia, acute myelogenous (AML) [MIM:601626]: A subtype of acute leukemia, a cancer of the white blood
    cells. AML is a malignant disease of bone marrow characterized by maturational arrest of hematopoietic precursors
    at an early stage of development. Clonal expansion of myeloid blasts occurs in bone marrow, blood, and other
    tissue. Myelogenous leukemias develop from changes in cells that normally produce neutrophils, basophils,
    eosinophils and monocytes. Note=The gene represented in this entry is involved in disease pathogenesis. Somatic
    mutations that lead to constitutive activation of KIT are detected in AML patients. These mutations fall into two
    classes, the most common being in-frame internal tandem duplications of variable length in the juxtamembrane
    region that disrupt the normal regulation of the kinase activity. Likewise, point mutations in the kinase domain
    can result in a constitutively activated kinase

  • Selected diseases for KIT (see all 80):    
    About MalaCards
    sarcoma    mastocytosis    systemic mastocytosis    germ cell tumors
    cutaneous mastocytosis    urticaria pigmentosa    sinonasal undifferentiated carcinoma    pseudoxanthomatous diffuse cutaneous mastocytosis
    mast-cell leukemia    plaque-form urticaria pigmentosa    classic mast cell leukemia    typical urticaria pigmentosa
    seminoma    gastrointestinal stromal tumor, familial    indolent systemic mastocytosis    uterine carcinosarcoma
    sm-ahnmd    isolated bone marrow mastocytosis    bullous diffuse cutaneous mastocytosis    nodular urticaria pigmentosa

    8 diseases from the University of Copenhagen DISEASES database for KIT:
    Gastrointestinal stromal tumor     Mastocytosis     Mesenchymal cell neoplasm     Leiomyosarcoma
    Piebaldism     Leiomyoma     Seminoma     Leukemia

    Find genes that share disorders with KIT           About GenesLikeMe

    Selected Novoseek inferred disease relationships for KIT gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gastrointestinal stromal tumor 97.7 442 11073817 (3), 18657298 (3), 18715619 (3), 11065242 (2) (see all 99)
    mastocytosis 89.8 156 9990072 (6), 15858149 (5), 9519779 (4), 7479840 (4) (see all 79)
    mastocytosis systemic 89.4 57 11380399 (3), 18500355 (2), 10632491 (2), 10721793 (1) (see all 36)
    leukemia mast cell 85.5 25 17949810 (5), 16093434 (2), 7536501 (1), 10910906 (1) (see all 13)
    piebaldism 82.7 51 11174389 (4), 19430803 (4), 15194144 (4), 1279971 (3) (see all 24)
    stromal tumors 82.7 34 18777214 (2), 15012791 (2), 15507676 (2), 19894031 (2) (see all 20)
    carney triad 78.6 3 17549339 (1), 18312355 (1), 17021135 (1)
    tumors 77.1 1063 12759497 (8), 15542802 (6), 15812822 (6), 19035443 (6) (see all 99)
    myeloid leukemia chronic 76.1 48 12480706 (1), 15126530 (1), 16143881 (1), 19509233 (1) (see all 41)
    seminoma 73.9 115 17768701 (6), 14695343 (4), 8551387 (4), 18045648 (4) (see all 41)

    Genetic Association Database (GAD): KIT
    Human Genome Epidemiology (HuGE) Navigator: KIT (266 documents)
    Tumor Gene Database (TGDB): KIT

    Export disorders for KIT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KIT gene, integrated from 10 sources (see all 2001):
    (articles sorted by number of sources associating them with KIT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence analysis of two genomic regions containing the KIT and the FMS receptor tyrosine kinase genes. (PubMed id 9027509)1, 2, 3, 9 Andre C.... Galibert F. (Genomics 1997)
    2. Correlation between KIT expression and KIT mutation in melanoma: a study of 173 cases with emphasis on the acral-lentiginous/mucosal type. (PubMed id 19718013)1, 4, 9 Torres-Cabala C.A....Ivan D. (Mod. Pathol. 2009)
    3. SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain. (PubMed id 9528781)1, 2, 9 Kozlowski M....Siminovitch K.A. (Mol. Cell. Biol. 1998)
    4. Analysis of c-KIT expression and KIT gene mutation in human mucosal melanomas. (PubMed id 19018266)1, 4, 9 Satzger I....Gutzmer R. (Br. J. Cancer 2008)
    5. KIT gene mutations and copy number in melanoma subtypes. (PubMed id 18980976)1, 4, 9 Beadling C....Corless C.L. (Clin. Cancer Res. 2008)
    6. Mutations in KIT occur at low frequency in melanomas arising from anatomical sites associated with chronic and intermittent sun exposure. (PubMed id 20088873)1, 4, 9 Handolias D....McArthur G.A. (amp 2010)
    7. Sorafenib inhibits imatinib-resistant KIT and platelet-derived growth factor receptor beta gatekeeper mutants. (PubMed id 17545544)1, 7, 9 Guida T....Carlomagno F. (Clin. Cancer Res. 2007)
    8. Melanoma hyperpigmentation is strongly associated with KIT alterations. (PubMed id 19652585)1, 4, 9 Wu J.M....Montgomery E.A. (Am J Dermatopathol 2009)
    9. Detection of c-KIT and PDGFRA gene mutations in gastrointestinal stromal tumors: comparison of DHPLC and DNA sequencing methods using a single population-based cohort. (PubMed id 20023271)1, 4, 9 Battochio A....Lai R. (Am. J. Clin. Pathol. 2010)
    10. Pediatric mastocytosis is a clonal disease associated with D816V and other activating c-KIT mutations. (PubMed id 19865100)1, 4, 9 Bodemer C....Dubreuil P. (J. Invest. Dermatol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3815 HGNC: 6342 AceView: KIT Ensembl:ENSG00000157404 euGenes: HUgn3815
    ECgene: KIT Kegg: 3815 H-InvDB: KIT

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KIT Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KIT Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=KIT[genesymbol]
    Wikipedia http://en.wikipedia.org/wiki/CD117

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KIT gene:
    Search GeneIP for patents involving KIT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Mono- and Polyclonal Antibodies for the study of KIT
     Browse Small Molecules at EMD Millipore
     EMD Millipore Purified and/or Recombinant KIT Protein
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     Antibodies for KIT (CD117/c-kit)   Browse Cell Culture Products  
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     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for KIT (CD117/c-kit)   Browse Stem Cell Products  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for KIT (CD117/c-kit)  
     OriGene Antibodies for KIT   OriGene RNAi products in human, mouse, rat for KIT  
     OriGene qPCR primer pairs and template standards for KIT   OriGene Protein Over-expression Lysate for KIT  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for KIT  
     OriGene qSTAR qPCR primer pairs in human, mouse for KIT   OriGene Purified Protein for KIT  
     OriGene ORF clones in mouse, rat for KIT   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KIT   OriGene Custom Protein Services for KIT  

     
     
     Block miRNA regulation of human, mouse, rat KIT using miScript Target Protectors SeqTarget long-range PCR primers for resequencing KIT
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KIT Predesigned siRNA for gene silencing in human, mouse, rat KIT
     QuantiFast Probe-based Assays in human, mouse, rat KIT QuantiTect SYBR Green Assays in human, mouse, rat KIT
     PCR Arrays including human, mouse, rat KIT Search Chromatin IP Primers for KIT
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KIT  GeneGlobe Interaction Network for KIT
     Regulatory tfbs in KIT promoter
     GenScript Custom Purified and Recombinant Proteins Services for KIT GenScript cDNA clones with any tag delivered in your preferred vector for KIT
     GenScript KIT-Activity-based Kinase Assay for Compound Screening GenScript Custom overexpressing Cell Line Services for KIT
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     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for KIT 

     Search Tocris compounds for KIT
     Proteins for KIT
     Cell Lysates for KIT
     cDNA Clones for KIT
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Drugs/Proteins for KIT
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     KIT antibodies
     KIT proteins
     KIT lysates
     Antibodies for KIT
     See all of Abcam's Antibodies, Kits and Proteins for KIT
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for KIT
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIT
     SwitchGear 3'UTR luciferase reporter plasmids for KIT
     SwitchGear Promoter luciferase reporter plasmids for KIT
     ThermoFisher Antibody for KIT
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIT
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KIT
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KIT
     LSBio Antibodies in human, mouse, rat for KIT
    Customized transgenic rodents for:
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     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for KIT
      Search eBioscience for proteins for KIT
      Search eBioscience for elisas for KIT
      eBioscience FlowRNA Probe Sets
           
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