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KIT Gene

protein-coding GIFtS: 72

GC04P055218

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
(Previous name: piebald trait )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: PBT)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
C-Kit ^¹, ²
CD117 ^¹, ²
EC 2.7.10.1 ^³
PBT ^², ⁵
SCFR ^¹, ², ³
c-kit ^³

Descriptions
CD117 antigen ^³
Proto-oncogene tyrosine-protein kinase Kit ^², ³
mast/stem cell growth factor receptor ^²
piebald trait ^¹
soluble KIT variant 1 ^²
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog ^²

External Ids
HGNC: 6342¹
Entrez Gene: 3815²
UniProtKB: P10721³
Ensembl: ENSG00000157404⁷

Search outside databases for aliases for KIT gene

Previous GC identifers: GC04P055328 GC04P055485 GC04P055439 GC04P055365

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for KIT:

This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the

cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3

transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor).

Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease,

acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different

isoforms have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: KIT_HUMAN, P10721

Function: This is the receptor for stem cell factor (mast cell growth factor). It has a

tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT

and its association with substrates such as phosphatidylinositol 3-kinase (Pi3K)

Gene Wiki entry for KIT (CD117)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the KIT gene

Entrez Gene cytogenetic band: 4q11-q12 Ensembl cytogenetic band: 4q12 HGNC cytogenetic band: 4q11-q12

KIT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P055218: (about GC identifiers)

Start:	55,218,852 bp from pter
End:	55,301,638 bp from pter
Size:	82,787 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000004.10 NT_022853.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: KIT_HUMAN, P10721 (See protein sequence)

Recommended Name: Mast/stem cell growth factor receptor precursor

Size: 976 amino acids; 109865 Da

Subunit: Interacts with APS. Interacts with MPDZ (via the tenth PDZ domain). Interacts with PTPRU

Subcellular location: Membrane; Single-pass type I membrane protein

PDB structures from and Proteopedia :

1PKG (3D)

1QZJ (3D)

1QZK (3D)

1R01 (3D)

1T45 (3D)

1T46 (3D)

2E9W (3D)

2EC8 (3D)

2VIF (3D)

3G0E (3D)

3G0F (3D)

Secondary accessions: Q9UM99

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_000213.1 NP_001087241.1

ENSEMBL proteins:

ENSP00000288135

Human Recombinant Proteins

	Invitrogen human recombinant proteins for KIT
	Millipore Purified and/or Recombinant KIT Protein
	Sigma-Aldrich Proteins for KIT
	R&D Systems Recombinant & Natural Proteins for KIT (SCF R/c-kit)
	Enzo Life Sciences proteins for KIT
	Recombinant Proteins from Abcam (c-Kit)
	Human Recombinant Proteins from Abnova (KIT)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IDA	14625290
GO:0005634	nucleus	IDA	18029348
GO:0005737	cytoplasm	IDA	18029348
GO:0005886	plasma membrane	IDA	18029348
GO:0009897	external side of plasma membrane	IEA	--

About this table

Antibodies for KIT:

	Invitrogen Antibodies for KIT
	Millipore Mono- and Polyclonal Antibodies for the study of KIT
	Sigma-Aldrich Antibodies for KIT
	R&D Systems Antibodies for KIT (SCF R/c-kit)
	Cell Signaling Technology (CST) Antibodies for KIT (c-Kit)
	Antibodies from Abcam (c-Kit), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (KIT)
	Novus Biologicals Antibodies for KIT

Assays for KIT:

	Invitrogen Assays for KIT
	Millipore Kits and Assays for the Analysis of KIT
	R&D Systems ELISAs for KIT (SCF R/c-kit) (see all)
	Cell Signaling Technology (CST) Sandwich ELISA Kits for KIT (c-Kit)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P10721

ProtoNet protein and cluster: P10721

3 Blocks protein families:

IPB001824 Receptor tyrosine kinase

IPB003598 Immunoglobulin C-2 type

IPB008266 Tyrosine protein kinase

UniProtKB/Swiss-Prot: KIT_HUMAN, P10721

Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF

receptor subfamily

Similarity: Contains 5 Ig-like C2-type (immunoglobulin-like) domains

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KIT)
		Millipore RNAi Products for the Analysis of KIT Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (KIT)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001093772

Applied Biosystems Silencer® siRNAs for KIT

Sigma-Aldrich siRNA and siRNA Panels for KIT

Sigma-Aldrich shRNA Panels and shRNA for KIT

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for KIT
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000222
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000222
untagged cDNA clones in CMV expression vector (see all 3): NM_000222

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000222

UniProtKB/Swiss-Prot: KIT_HUMAN, P10721

Function: This is the receptor for stem cell factor (mast cell growth factor). It has a

tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT

and its association with substrates such as phosphatidylinositol 3-kinase (Pi3K)

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

Enzyme Number (IUBMB): EC 2.7.10.1

Genatlas biochemistry entry for KIT:

Hardy-Zuckerman 4 feline sarcoma viral (v-kit or c-kit) oncogene homolog,homologous to murine

dominant spotting,involved in melanogenesis

15/26 MGI mutant phenotypes (inferred from 97 alleles) (MGI details for Kit) (see all 26 ):

	cellular	craniofacial	digestive/alimentary	endocrine/exocrine gland
growth/size	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system
lethality-postnatal	lethality-prenatal/perinatal	life span-post-weaning/aging	limbs/digits/tail	liver/biliary system

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004716	receptor signaling protein tyrosine kinase activity	TAS	9438854
GO:0004872	receptor activity	IEA	--
GO:0005020	stem cell factor receptor activity	IEA	--
GO:0005515	protein binding	IPI	17662946

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for KIT (Your Favorite Gene powered by Ingenuity)

Acute Myeloid Leukemia Signaling
Melanocyte Development and Pigmentation Signaling

GeneDecks KIT for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for KIT

2 Interacting proteins for KIT (P10721¹) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
KITLG P21583¹ EBI-1379503, EBI-1379527
PTPRJ Q12913¹ EBI-1379503, EBI-2264500
About this table
5/13 Gene Ontology (GO) biological process terms (links to tree view) (see all 13 ):
GO ID Qualified GO term Evidence PubMed IDs
GO:0002573 myeloid leukocyte differentiation IEA --
GO:0007165 signal transduction TAS 9990072
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA --
GO:0007243 protein kinase cascade IEA --
GO:0007283 spermatogenesis IEA --
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for KIT:

Inhibitor

Browse Tocris compounds for KIT
10/41 Novoseek chemical compound relationships for KIT gene (see all 41 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	88.81	898	16287490 (7), 9528781 (5), 12600228 (4), 17949810 (4) (see all 99)
mln 518	68.62	12	15304388 (4), 15242881 (3), 16902153 (1)
ag-1296	63.06	7	7954456 (1), 12512837 (1), 17654122 (1)
beta-tyrosine	60.62	3	10786682 (1), 17272980 (1), 14871970 (1)
su6668	60.58	5	11222388 (3), 16144927 (1), 12888313 (1)
amn107	56.69	6	16797704 (3), 16189265 (2), 17363509 (1)
17-(allylamino)-17-demethoxygeldanamycin	51.55	4	16213582 (2), 18399173 (1), 14551138 (1)
phosphatidylinositol	40.90	24	1372092 (2), 14695343 (1), 9092574 (1), 17452978 (1) (see all 15)
monochloroacetic acid	37.20	6	9140315 (2), 9273545 (1), 12436291 (1)
toluidine	35.46	11	10432289 (2), 16334197 (1), 18500266 (1), 12826896 (1) (see all 6)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KIT)
		Millipore RNAi Products for the Analysis of KIT Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (KIT)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001093772

Sigma-Aldrich siRNA and siRNA Panels for KIT

Sigma-Aldrich shRNA Panels and shRNA for KIT

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000222 NM_001093772

REFSEQ mRNAs for KIT gene (2 alternative transcripts):

NM_000222.2 NM_001093772.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000222 NM_001093772

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000222
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000222
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_000222

Additional cDNA sequence:

AJ438313.1 AK304031.1 BC071593.1 EU826594.1 X06182.1

1 DOTS entry:

DT.115605

24/95 AceView cDNA sequences (see all 95 ):

AI567693 AW468784 BM713257 AI674108 AA481776 AI567686 AW264522 BX642234

AI308810 AI696267 AU108050 AI143554 BX955809 BC071593 BX478628 BM971784

AW271802 AW244098 AJ438313 AI890068 AU100291 AW949528 AA873164 AI355325

highest scoring ESTs for KIT:

X06182 AA143045 AA403148 AA481776 AI674108 AL048483 AW879367 AW879393 AW879433 AW949528

Unigene Cluster for KIT:

V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

Hs.479754 [show with all ESTs]

Unigene Representative Sequence: NM_000222

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for KIT (see all 6 )

ExUns:	1	^	2a	·	2b	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8a	·	8b	^	9a	·	9b	^	10	^	11a	·	11b	^	12	^	13a	·	13b	^	14a	·	14b	^	15	^	16a	·	16b	^	17a	·	17b	^
SP1:					-																																		-												-
SP2:																																							-
SP3:
SP4:																									-
SP5:

ExUns:	18	^	19	^	20	^	21
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for KIT

1 Ensembl transcript including schematic representation:

ENST00000288135

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

KIT expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for KIT

¹ / ² / ³

3 probe-sets matching KIT gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1888_s_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X06182	1.00	1.00	1.00	1
205051_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000222	0.60	1.00	0.82	1
205051_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGTCCTTGAA

SOURCE GeneReport for Unigene cluster: Hs.479754
Expression variation in blood from EXPOLDB for KIT

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for KIT gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	KIT¹	--	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene more	88.34(n) 88.58(a)	403811 NM_001003181.1 NP_001003181.1
chimpanzee (Pan troglodytes)	KIT¹	--	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene more	99.55(n) 99.69(a)	461316 XM_517285.2 XP_517285.2
cow (Bos taurus)	KIT¹	--	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene more	87.79(n) 89.93(a)	280832 XM_612028.3 XP_612028.3
rat (Rattus norvegicus)	Kit¹	--	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene more	83.2(n) 84.19(a)	64030 NM_022264.1 NP_071600.1
mouse (Mus musculus)	Kit^{1, 5}	5 (42.00 cM)⁵	kit oncogene^{1, 5}	82.75(n)¹ 82.78(a)¹	16590¹ NM_021099.2¹ NP_066922.1¹ AF356350⁵ AK046795⁵ (see all 23)

About this table Species with no ortholog for KIT

ENSEMBL Gene Tree for KIT

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for KIT gene

CSF1R² FLT3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/517 NCBI SNPs in KIT are shown (see all 517 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 218)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2213181^1,2	A,C,F,H	55299629(+)	`GTGGCC/TGATGA`	2	--	ut3¹ ese³		4		EU EA WA	418
	rs8022^1,2	A,C,F,H	55301184(+)	`GGGTTG/TTGTTG`	2	--	ut3¹		8		MN EU EA NA	808
	rs3796776^1,2	A,C,F,H	55301967(+)	`CCAAAC/GAGAGG`	2	--	ng3¹		17		EA NA EU WA	2874
	rs6554198^1,2	A,C,F,H	55216917(+)	`ATGACA/GGTCCA`	2	--	ng5¹		7		NA EU EA WA	554
	rs6554199^1,2	A,C,F,H	55217245(+)	`CCTTTG/TGTATT`	2	--	ng5¹		8		EA NA EU WA	626
--	rs3822214^1,2	C,F,H	55288221(+)	`TTGTGA/C/GTGATT`	4	M/L M/V	mis¹		8		EA WA EU	1426
	rs1005438^1,2	A,C	55218695(+)	`GGCACA/GGCCCC`	2	--	ng5¹		0	--	--	--	--
	rs17084733^1,2	F,H	55299697(+)	`GCAACG/ATAGCT`	2	--	ut3¹ ese³		7		NA EU EA WA	562
	rs35200131^1,2	C	55290339(+)	`TATTTG/CTTCAA`	2	S/C	mis¹		4		EU EA WA	420
	rs1123629^1,2	H	55218189(+)	`CGCCCC/TTGTCT`	2	--	ng5¹		6		NA MN EU EA WA	686

About this table

HapMap Linkage Disequilibrium images for KIT (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 164920

UniProtKB/Swiss-Prot: KIT_HUMAN, P10721

Defects in KIT are a cause of piebaldism [MIM:172800]. Piebaldism is an autosomal dominant

genetic developmental abnormality of pigmentation characterized by congenital patches of white

skin and hair that lack melanocytes

Defects in KIT are a cause of gastrointestinal stromal tumor (GIST) [MIM:606764]

Defects in KIT have been associated with testicular tumors [MIM:273300]. It includes germ

cell tumor (GCT) or testicular germ cell tumor (TGCT)

10/94 Novoseek disease relationships for KIT gene (see all 94 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
gastrointestinal stromal tumor	97.55	392	11073817 (3), 18657298 (3), 18715619 (3), 11065242 (2) (see all 99)
mastocytosis	89.57	146	9990072 (6), 15858149 (5), 9519779 (4), 7479840 (4) (see all 73)
mastocytosis systemic	88.80	54	11380399 (3), 18500355 (2), 10632491 (2), 10721793 (1) (see all 33)
leukemia mast cell	85.42	24	17949810 (5), 16093434 (2), 7536501 (1), 10910906 (1) (see all 12)
stromal tumors	83.10	32	18777214 (2), 15012791 (2), 15507676 (2), 16258510 (1) (see all 19)
piebaldism	82.91	46	11174389 (4), 15194144 (4), 1279971 (3), 7534102 (3) (see all 23)
carney triad	77.20	3	17549339 (1), 18312355 (1), 17021135 (1)
tumors	75.86	978	12759497 (8), 15542802 (6), 15812822 (6), 19035443 (6) (see all 99)
myeloid leukemia chronic	75.49	45	12480706 (1), 15126530 (1), 16143881 (1), 11840282 (1) (see all 38)
smooth muscle tumor	75.33	14	11127756 (1), 16400320 (1), 17193824 (1), 9916918 (1) (see all 11)

About this table

Human Gene Mutation Database: KIT
Genetic Association Database: KIT
Human Genome Epidemiology Navigator: KIT (162 documents)
Tumor Gene Database: KIT
Breast Cancer Gene Database: KIT

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1462 PubMed articles for KIT gene (see all 1462 ):

Sequence analysis of two genomic regions containing the KIT and the FMS receptor tyrosine kinase genes. (PubMed id 9027509)^{1, 2, 3, 4} Andre C.... Galibert F. (1997)
Deletions affecting codons 557-558 of the c-KIT gene indicate a poor prognosis in patients with completely resected gastrointestinal stromal tumors: a study by the Spanish Group for Sarcoma Research (GEIS). (PubMed id 16135486)^{1, 3, 6} Martin J....Buesa J.M. (2005)
Novel mutations of the KIT (mast/stem cell growth factor receptor) proto-oncogene in human piebaldism. (PubMed id 7687267)^{1, 3, 4} Spritz R.A.... Kuester W. (1993)
Human piebald trait resulting from a dominant negative mutant allele of the c-kit membrane receptor gene. (PubMed id 1376329)^{1, 3, 4} Fleischman R.A. (1992)
Mutation of the KIT (mast/stem cell growth factor receptor) protooncogene in human piebaldism. (PubMed id 1717985)^{1, 3, 4} Giebel L.B. and Spritz R.A. (1991)
Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype. (PubMed id 16076867)^{1, 3, 6} Schnittger S....Falini B. (2005)
Activating c-kit gene mutations in human germ cell tumors. (PubMed id 10362788)^{1, 3, 4} Tian Q.... Moskaluk C.A. (1999)
Activating and dominant inactivating c-KIT catalytic domain mutations in distinct clinical forms of human mastocytosis. (PubMed id 9990072)^{1, 3, 4} Longley B.J. Jr.... Ma Y. (1999)
Piebaldism with deafness: molecular evidence for an expanded syndrome. (PubMed id 9450866)^{1, 3, 4} Spritz R.A. and Beighton P. (1998)
Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder. (PubMed id 7479840)^{1, 3, 6} Nagata H....Metcalfe D.D. (1995)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3815	HGNC: 6342	AceView: KIT	Ensembl:ENSG00000157404	euGenes: HUgn3815
ECgene: KIT	H-InvDB: KIT

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for KIT	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.genetests.org/query?gene=KIT
Wikipedia	http://en.wikipedia.org/wiki/CD117

Licensable Technologies for KIT
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for KIT:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for KIT-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for KIT		Antibodies for KIT
	Explore super-pooled esiRNAs		Proteins for KIT
	Lentivirus-delivered shRNAs for KIT		Small molecules for KIT
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (KIT)
	Antibodies (KIT)
	Chimera RNAi (KIT)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for KIT (c-Kit)

	Recombinant Proteins (c-Kit)
	Antibodies (c-Kit)

Search OriGene for KIT

Search Tocris compounds for KIT

	Proteins for KIT
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for KIT

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
KIT Gene at Home site.
Version 2.41.1
server4.xennexinc.com

KIT Gene

protein-coding GIFtS: 72

Aliases &
Descriptions
for KIT

Summaries
for KIT

Genomic Location
for KIT

Proteins
for KIT

Protein Domains/
Families
for KIT

Gene Function
for KIT

Pathways & Interactions
for KIT

Drugs & Compounds
for KIT

Transcripts
for KIT

Expression
for KIT

Orthologs
for KIT

Paralogs
for KIT

SNPs/Variants
for KIT

Disorders & Mutations
for KIT

Medical News
for KIT

Publications
for KIT

Search for KIT

Genome Databases showing KIT

Other Databases showing KIT

Specialized Databases showing KIT

Licensable Technologies
for KIT

Services
for KIT

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

KIT Gene

protein-coding GIFtS: 72

Aliases & Descriptionsfor KIT

Summariesfor KIT

Genomic Locationfor KIT

Proteinsfor KIT

Protein Domains/Familiesfor KIT

Gene Functionfor KIT

Pathways & Interactionsfor KIT

Drugs & Compoundsfor KIT

Transcriptsfor KIT

Expression for KIT

Orthologsfor KIT

Paralogsfor KIT

SNPs/Variantsfor KIT

Disorders & Mutationsfor KIT

Medical Newsfor KIT

Publicationsfor KIT

Search for KIT

Genome Databases showing KIT

Other Databases showing KIT

Specialized Databases showing KIT

Licensable Technologiesfor KIT

Servicesfor KIT

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for KIT

Summaries
for KIT

Genomic Location
for KIT

Proteins
for KIT

Protein Domains/
Families
for KIT

Gene Function
for KIT

Pathways & Interactions
for KIT

Drugs & Compounds
for KIT

Transcripts
for KIT

Expression
for KIT

Orthologs
for KIT

Paralogs
for KIT

SNPs/Variants
for KIT

Disorders & Mutations
for KIT

Medical News
for KIT

Publications
for KIT

Licensable Technologies
for KIT

Services
for KIT