KISS1R Gene
protein-coding GIFtS: 61
GCID: GC19P000917
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|
KISS1 receptor(Previous name: G protein-coupled receptor 54 )
(Previous symbol: GPR54)
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Aliases
for KISS1R gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| KISS1 Receptor1 2 | | HH82 | | GPR541 2 3 5 | | KISS-1R2 | | AXOR121 2 3 | | Hypogonadotropin-13 | | HOT7T1751 2 | | KiSS-1 Receptor2 | | G Protein-Coupled Receptor 541 2 | | Hypogonadotropin-13 | | Kisspeptins Receptor2 3 | | KiSS-1R3 | | Metastin Receptor2 3 | | G-Protein Coupled Receptor 543 | | G-Protein Coupled Receptor OT7T1752 3 | | HOT7T1751 2 |
Export aliases for KISS1R gene to outside databasesPrevious GC identifers: GC19P000870 GC19P000694 |
Summaries
for KISS1R gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KISS1R:
The protein encoded by this gene is a galanin-like G protein-coupled receptor that binds metastin, a peptide encoded bythe metastasis suppressor gene KISS1. The tissue distribution of the expressed gene suggests that it is involved inthe regulation of endocrine function, and this is supported by the finding that this gene appears to play a role inthe onset of puberty. Mutations in this gene have been associated with hypogonadotropic hypogonadism and centralprecocious puberty. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: KISSR_HUMAN, Q969F8Function: Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is ametastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas withoutaffecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest andinduction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormonephysiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of thegonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation andfine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathwaysactivated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussistoxin-insensitive G(q) proteins
 summary
for KISS1R: The KISS-derived peptide receptor (KISS1) is a Gq/G11-protein-coupled receptor that signals through
stimulation of phospholipase C resulting in Ca2+ mobilization. The KISS1 receptor is found at high
concentrations in the pancreas, placenta and brain and there are lower expression levels in the small
intestine, kidney, lung, liver and heart. The KISS-derived peptide receptor plays a key role in the
neuroendocrine control of the gonadotrophin axis and has been implicated in the inhibition of metastasis.
The human KISS1 receptor gene is localized on chromosome 19p13.3.
Gene Wiki entry for KISS1R (KiSS1-derived peptide receptor)
|
Genomic Views
for KISS1R gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KISS1R gene promoter:
p53 AP-2beta AP-2alpha AP-2gamma AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for KISS1R
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KISS1R |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3KISS1R Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P000917: view genomic region
(about GC identifiers)
Start:
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917,287 bp from pter |
End:
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921,015 bp from pter |
Size:
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3,729 bases |
Orientation:
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plus strand |
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Proteins
for KISS1R gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KISSR_HUMAN, Q969F8 (See
protein sequence)Recommended Name: KiSS-1 receptor Size: 398 amino acids; 42586 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: A5D8U2 B2RTV1 Q96QG0Explore the universe of human proteins at neXtProt for KISS1R: NX_Q969F8
KISS1R Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115940.2
ENSEMBL proteins: ENSP00000467666 ENSP00000234371 Reactome Protein details: Q969F8
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
KISS1R for ontologies About GeneDecksing
KISS1R Antibody Products:
Assay Products for KISS1R: |
Protein
Domains /
Families
for KISS1R gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KISS1R for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q969F8ProtoNet protein and cluster: Q969F8 1 Blocks protein family: IPB008103 KiSS-1 peptide receptor signature
UniProtKB/Swiss-Prot: KISSR_HUMAN, Q969F8Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for KISS1R gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KISSR_HUMAN, Q969F8Function: Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is ametastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas withoutaffecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest andinduction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormonephysiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of thegonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation andfine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathwaysactivated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussistoxin-insensitive G(q) proteinsInduction: Expressed at higher levels in first trimester trophoblasts than at term of gestation
Clone
Products: |  | EMD Millipore Clones for the Expression of KISS1R | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KISS1R (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KISS1R
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: KISS1R (NM_032551) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KISS1R | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KISS1R |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
KISS1R for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for KISS1R: Kiss1rtm1.1Lex Kiss1rtm1Coll Kiss1rtm1Rla
14 MGI mutant phenotypes (inferred from 6 alleles ) (MGI details for Kiss1r):
KISS1R for phenotypes About GeneDecksing
|
Pathways & Interactions
for KISS1R gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | Signaling by GPCR | | | 3 | G alpha (q) signalling events | | | 4 | Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for KISS1R
5/8 
Reactome Pathways for KISS1R (see all 8)
1 
Kegg Pathway (Kegg details for KISS1R):
KISS1R for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KISS1R
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/124 Interacting proteins for KISS1R (Q969F82, 3 ENSP000002343714) via UniProtKB, MINT, STRING, and/or I2D (see all 124)About this table
Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table
KISS1R for ontologies About GeneDecksing
|
Drugs & Compounds
for KISS1R gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
KISS1R for compounds About GeneDecksing
Compounds for KISS1R available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| Metastin (human) | Potent, endogenous ligand for KISS1 receptor (hOT7T175/AXOR12/GPR54) | [374683-24-6] | | Kisspeptin 10 (rat) | Endogenous ligand for KISS1 receptor | [478507-53-8] | | Kisspeptin 10 (human) | Endogenous ligand for KISS1 receptor (hOT7T175/AXOR12/GPR54) | [374675-21-5] |
1 HMDB Compound for KISS1R About this table
7 Novoseek chemical compound relationships for KISS1R gene About this table
Search CenterWatch for drugs/clinical trials and news about KISS1R / KISSR
|
Transcripts
for KISS1R gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KISS1R gene: NM_032551.4 Unigene Cluster for KISS1R: KISS1 receptor Hs.208229 [show with all ESTs]Unigene Representative Sequence: BC1418122 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000592648 ENST00000234371(uc002lqk.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KISS1R (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KISS1R
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KISS1R (NM_032551) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KISS1R | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KISS1R |
Additional cDNA sequence: AB051065.1 AF343725.1 AJ309020.1 AY029541.1 AY253981.1 AY253982.1 BC140825.1 BC141812.1 EU883577.1 2 DOTS entries: DT.75139537 DT.102820566 16 AceView cDNA sequences: CR621438 AY253981 NM_032551 AJ309020 AY253982 AB051065 AY029541 AF343725 CA432866 AL541044 BV192553 AA887801 AI823800 CA487873 AI819198 AL568705
GeneLoc Exon Structure
|
Expression
for KISS1R gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KISS1R expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTCAACACA
About this image
See KISS1R Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KISS1R
SOURCE GeneReport for Unigene cluster: Hs.208229
UniProtKB/Swiss-Prot: KISSR_HUMAN, Q969F8Tissue specificity: Most highly expressed in the pancreas, placenta and spinal cord, with lower-level of expression inperipheral blood leukocytes, kidney, lung, fetal liver, stomach, small intestine, testes, spleen, thymus, adrenalglands and lymph nodes. In the adult brain, expressed in the superior frontal gyrus, putamen, caudate nucleus,cingulate gyrus, nucleus accumbens, hippocampus, pons and amygdala, as well as the hypothalamus and pituitary.Expression levels are higher in early (7-9 weeks) than term placentas. Expression levels were increased in both earlyplacentas and molar pregnancies and were reduced in choriocarcinoma cells. Expressed at higher levels in firsttrimester trophoblasts than at term of gestation. Also found in the extravillous trophoblast suggestingendocrine/paracrine activation mechanism
SABiosciences Expression via Pathway-Focused PCR Arrays including KISS1R:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KISS1R
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KISS1R | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KISS1R | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KISS1R |
Orthologs
for KISS1R gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for KISS1R gene from 4/15 species (see all 15) About this table
ENSEMBL Gene Tree for KISS1R (if available)
TreeFam Gene Tree for KISS1R (if available) |
Paralogs
for KISS1R gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KISS1R gene
- SSTR32 OPRL12 OPRK12 NPBWR12 OPRD12 GALR12 SSTR42 GALR22
- SSTR52 MCHR22 SSTR12 GALR32 SSTR22 NPBWR22 MCHR12 OPRM12
13 SIMAP similar genes for KISS1R using alignment to 2 protein entries: KISSR_HUMAN (see all proteins):GALR2 GALR1 PRLHR OPRK1 SSTR1 SSTR4
GALR3 NPBWR1 OPRD1 OPRL1 SSTR2 SSTR3
SSTR5
KISS1R for paralogs About GeneDecksing
|
Genomic Variants
for KISS1R gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KISS1R (917287 - 921015 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for KISS1R
2 CNVs: 30055 30056
Human Gene Mutation Database (HGMD): KISS1R
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KISS1R |
|
Disorders
/ Diseases
for KISS1R gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KISS1R for disorders About GeneDecksing
OMIM gene information: 604161
OMIM disorders: 146110 176400
UniProtKB/Swiss-Prot: KISSR_HUMAN, Q969F8
Defects in KISS1R are the cause of hypogonadotropic hypogonadism 8 with or without anosmia (HH8) [MIM:614837].A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with lowlevels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. Insome cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineuralhearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts.Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonicmigration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathichypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell,it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH) Defects in KISS1R are a cause of central precocious puberty (CEPREPU) [MIM:176400]. Precocious puberty isdefined as the development of secondary sexual characteristics before the age of 8 years in girls and 9 years in boys.Central precocious puberty refers to a gonadotropin-dependent type which results from premature activation of thehypothalamic-pituitary-gonadal axis
20/38  diseases for KISS1R (see all 38): About MalaCardsprecocious puberty isolated gonadotropin-releasing hormone (gnrh) deficiency hypogonadotropism hypogonadism
central precocious puberty down syndrome critical region delayed puberty kallmann syndrome
gonadotropin deficiency klinefelter's syndrome esophageal squamous cell carcinoma squamous cell carcinoma
transitional cell carcinoma down syndrome epithelial ovarian cancer pituitary adenoma
thyroid cancer renal cell carcinoma hepatocellular carcinoma carcinoma
3 diseases from the University of Copenhagen DISEASES database for KISS1R:Klinefelter's syndrome Hypogonadism Hypogonadotropism 10/12 Novoseek disease relationships for KISS1R gene (see all 12) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| kallmann syndrome |
84.9 |
2 |
16606836 (1), 15554891 (1) |
| klinefelters syndrome |
71.5 |
6 |
17164310 (2), 15598687 (1), 20237166 (1), 17624596 (1) |
| puberty delayed |
70.1 |
1 |
19228890 (1) |
| hypogonadism |
59.9 |
3 |
16302709 (2), 19554077 (1) |
| metastasis |
53.4 |
27 |
14977840 (3), 19286835 (2), 16277902 (2), 12650602 (1) (see all 20) |
| papillary thyroid cancer |
38.9 |
1 |
11994395 (1) |
| carcinoma renal cell |
23.7 |
5 |
18395323 (1), 18395325 (1), 18395329 (1), 18834661 (1) (see all 5) |
| cancer |
23 |
3 |
15013429 (1), 18550222 (1), 17206526 (1) |
| thyroid cancer |
22.5 |
7 |
11994395 (5), 15998767 (2) |
| tumors |
21.5 |
35 |
14977840 (3), 19154616 (3), 16277902 (2), 12650602 (1) (see all 15) |
GeneTests: KISS1R
Hypogonadotropic Hypogonadism
Human Genome Epidemiology (HuGE) Navigator: KISS1R (10 documents)
Export disorders for KISS1R gene to outside databases
|
Publications
for KISS1R gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KISS1R gene, integrated from 9 sources (see all 157):
(articles sorted by number of sources associating them with KISS1R) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Metastin receptor is overexpressed in papillary thyroid cancer and activates MAP kinase in thyroid cancer cells. (PubMed id 11994395)1, 2, 9 Ringel M.D.... Saji M. (2002)
- AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1. (PubMed id 11387329)1, 2, 9 Muir A.I.... Harrison D.C. (2001)
- Clinical significance of the loss of KiSS-1 and orphan G-protein- coupled receptor (hOT7T175) gene expression in esophageal squamous cell carcinoma. (PubMed id 14977840)1, 2, 9 Ikeguchi M.... Kaibara N. (2004)
- The GPR54 gene as a regulator of puberty. (PubMed id 14573733)1, 2, 9 Seminara S.B.... Colledge W.H. (2003)
- Hypogonadotropic hypogonadism due to loss of function of the KiSS1- derived peptide receptor GPR54. (PubMed id 12944565)1, 2, 9 de Roux N....Milgrom E. (2003)
- Quantitative reverse transcriptase polymerase chain reaction analysis for KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in hepatocellular carcinoma. (PubMed id 12898236)1, 2, 9 Ikeguchi M.... Kaibara N. (2003)
- Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells. (PubMed id 12414911)1, 2, 9 Janneau J.-L.... Bellet D. (2002)
- Two novel missense mutations in G protein-coupled receptor 54 in a patient with hypogonadotropic hypogonadism. (PubMed id 15598687)1, 2, 9 Semple R.K.... Aparicio S.A. (2005)
- Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G- protein-coupled receptor. (PubMed id 11385580)1, 2, 9 Ohtaki T.... Fujino M. (2001)
- Activation of GPR54 promotes cell cycle arrest and apoptosis of human tumor cells through a specific transcriptional program not shared by other G(q)-coupled receptors. (PubMed id 15596153)1, 2 Becker J.A.J.... Libert F. (2005)
|
External Searches for KISS1R gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KISS1R gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KISS1R gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KISS1R gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KISS1R | Pharmacogenomics, SNPs, Pathways | | Protein Spotlight | http://web.expasy.org/spotlight/back_issues/sptlt058.shtml | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/KISS1R |
|
| | |
About This Section
| Patent Information for KISS1R gene:
Search GeneIP for patents involving KISS1R
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for KISS1R gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KISS1R | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KISS1R | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KISS1R | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KISS1R | | OriGene 3'-UTR Clone for KISS1R | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KISS1R | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KISS1R | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for KISS1R | | OriGene Custom Protein Services for KISS1R | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KISS1R | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KISS1R | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KISS1R | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KISS1R | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KISS1R | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KISS1R |
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 | | | KISS1R Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for KISS1R |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KISS1R |
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