Aliases for KISS1R Gene
External Ids for KISS1R Gene
Previous Symbols for KISS1R Gene
The protein encoded by this gene is a galanin-like G protein-coupled receptor that binds metastin, a peptide encoded by the metastasis suppressor gene KISS1. The tissue distribution of the expressed gene suggests that it is involved in the regulation of endocrine function, and this is supported by the finding that this gene appears to play a role in the onset of puberty. Mutations in this gene have been associated with hypogonadotropic hypogonadism and central precocious puberty. [provided by RefSeq, Jul 2008]
GeneCards Summary for KISS1R Gene
KISS1R (KISS1 Receptor) is a Protein Coding gene. Diseases associated with KISS1R include hypogonadotropic hypogonadism 8 with or without anosmia and central precocious puberty. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include neuropeptide receptor activity and neuropeptide binding. An important paralog of this gene is GALR2.
UniProtKB/Swiss-Prot for KISS1R Gene
Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins.
The KISS-derived peptide receptor (KISS1) is a Gq/G11-protein-coupled receptor that signals through stimulation of phospholipase C resulting in Ca2+ mobilization. The KISS1 receptor is found at high concentrations in the pancreas, placenta and brain and there are lower expression levels in the small intestine, kidney, lung, liver and heart. The KISS-derived peptide receptor plays a key role in the neuroendocrine control of the gonadotrophin axis and has been implicated in the inhibition of metastasis. The human KISS1 receptor gene is localized on chromosome 19p13.3.