Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KISS1 Gene

Aliases for KISS1 Gene

  • KiSS-1 Metastasis-Suppressor 2 3
  • Prepro-Kisspeptin 2 3
  • Kisspeptin-1 3 4
  • HH13 3 6
  • Malignant Melanoma Metastasis-Suppressor 3
  • Metastasis-Suppressor KiSS-1 3
  • Kisspeptin 2
  • Metastin 3
  • KiSS-1 3

External Ids for KISS1 Gene

Previous GeneCards Identifiers for KISS1 Gene

  • GC01M201883
  • GC01M199620
  • GC01M200520
  • GC01M201336
  • GC01M200892
  • GC01M202426
  • GC01M175324

Summaries for KISS1 Gene

Entrez Gene Summary for KISS1 Gene

  • This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH nuerons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues. [provided by RefSeq, Mar 2012]

GeneCards Summary for KISS1 Gene

KISS1 (KiSS-1 Metastasis-Suppressor) is a Protein Coding gene. Diseases associated with KISS1 include hypogonadotropic hypogonadism 13 with or without anosmia and kiss1-related isolated gonadotropin-releasing hormone deficiency. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include kisspeptin receptor binding.

UniProtKB/Swiss-Prot for KISS1 Gene

  • Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.

Gene Wiki entry for KISS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KISS1 Gene

Genomics for KISS1 Gene

Genomic Location for KISS1 Gene

Start:
204,190,341 bp from pter
End:
204,196,491 bp from pter
Size:
6,151 bases
Orientation:
Minus strand

Genomic View for KISS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KISS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KISS1 Gene

Proteins for KISS1 Gene

  • Protein details for KISS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15726-KISS1_HUMAN
    Recommended name:
    Metastasis-suppressor KiSS-1
    Protein Accession:
    Q15726
    Secondary Accessions:
    • A8K6N0
    • Q9HBP1

    Protein attributes for KISS1 Gene

    Size:
    138 amino acids
    Molecular mass:
    14705 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC79512.1; Type=Frameshift; Positions=138; Evidence={ECO:0000305}; Sequence=AAM78592.1; Type=Frameshift; Positions=138; Evidence={ECO:0000305};

neXtProt entry for KISS1 Gene

Proteomics data for KISS1 Gene at MOPED

Post-translational modifications for KISS1 Gene

Other Protein References for KISS1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for KISS1 Gene

Domains for KISS1 Gene

Gene Families for KISS1 Gene

HGNC:

Protein Domains for KISS1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KISS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15726

UniProtKB/Swiss-Prot:

KISS1_HUMAN :
  • Q15726
Family:
  • Belongs to the KISS1 family.
genes like me logo Genes that share domains with KISS1: view

Function for KISS1 Gene

Molecular function for KISS1 Gene

GENATLAS Biochemistry: KISS1 metastasis suppressor in malignant melonoma,and at least in some human breast cancers
UniProtKB/Swiss-Prot Function: Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.
UniProtKB/Swiss-Prot Induction: Down-regulated during the progression of melanoma in vivo. Diminishes MMP9 expression by effecting reduced NF-kappa-B binding to the promoter.

Gene Ontology (GO) - Molecular Function for KISS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11387329
genes like me logo Genes that share ontologies with KISS1: view
genes like me logo Genes that share phenotypes with KISS1: view

Animal Models for KISS1 Gene

MGI Knock Outs for KISS1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KISS1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for KISS1 Gene

Localization for KISS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KISS1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KISS1 Gene COMPARTMENTS Subcellular localization image for KISS1 gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 2
cytosol 1

Gene Ontology (GO) - Cellular Components for KISS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with KISS1: view

Pathways for KISS1 Gene

genes like me logo Genes that share pathways with KISS1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for KISS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization TAS 9192814
genes like me logo Genes that share ontologies with KISS1: view

Compounds for KISS1 Gene

(9) Novoseek inferred chemical compound relationships for KISS1 Gene

Compound -log(P) Hits PubMed IDs
gnrh 80.8 39
testosterone 36.2 10
glyceraldehyde 3-phosphate 31.1 4
steroid 25.5 3
estrogen 18.6 6
genes like me logo Genes that share compounds with KISS1: view

Transcripts for KISS1 Gene

mRNA/cDNA for KISS1 Gene

(335) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KISS1 Gene

KiSS-1 metastasis-suppressor:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KISS1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KISS1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2:

Relevant External Links for KISS1 Gene

GeneLoc Exon Structure for
KISS1
ECgene alternative splicing isoforms for
KISS1

Expression for KISS1 Gene

mRNA expression in normal human tissues for KISS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KISS1 Gene

This gene is overexpressed in Pituitary (10.8), Testis (7.6), Liver (4.8), and Brain - Hypothalamus (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KISS1 Gene

SOURCE GeneReport for Unigene cluster for KISS1 Gene Hs.95008

mRNA Expression by UniProt/SwissProt for KISS1 Gene

Q15726-KISS1_HUMAN
Tissue specificity: Very high expression in placenta, with the next highest level in testis and moderate levels in pancreas, liver, small intestine and brain at much lower levels. Expression levels increased in both early placentas and molar pregnancies and are reduced in choriocarcinoma cells. Expressed at higher levels in first trimester trophoblasts than at term of gestation, but only expressed in the villous trophoblast.
genes like me logo Genes that share expressions with KISS1: view

In Situ Assay Products

Orthologs for KISS1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KISS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KISS1 35
  • 99.03 (n)
  • 98.55 (a)
KISS1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KISS1 35
  • 77.96 (n)
  • 61.16 (a)
KISS1 36
  • 59 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kiss1 35
  • 70.11 (n)
  • 52.38 (a)
Kiss1 16
Kiss1 36
  • 53 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KISS1 36
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KISS1 36
  • 44 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kiss1 35
  • 66.67 (n)
  • 49.23 (a)
Species with no ortholog for KISS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KISS1 Gene

ENSEMBL:
Gene Tree for KISS1 (if available)
TreeFam:
Gene Tree for KISS1 (if available)

Paralogs for KISS1 Gene

No data available for Paralogs for KISS1 Gene

Variants for KISS1 Gene

Sequence variations from dbSNP and Humsavar for KISS1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2510 -- 204,192,463(+) AAGTT(C/T)CTTCT intron-variant
rs4889 - 204,190,659(-) GAGCC(C/G)CCAGC reference, missense
rs12998 - 204,192,819(-) TTGGG(A/G)AGCCA missense, reference
rs1132112 -- 204,190,763(-) GCCCC(C/G)GGGGA reference, synonymous-codon
rs1132478 -- 204,190,432(-) GCATG(C/T)GGGGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KISS1 Gene

Variant ID Type Subtype PubMed ID
esv2627051 CNV Insertion 19546169
esv2721829 CNV Deletion 23290073
nsv528249 CNV Loss 19592680

Relevant External Links for KISS1 Gene

HapMap Linkage Disequilibrium report
KISS1
Human Gene Mutation Database (HGMD)
KISS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KISS1 Gene

Disorders for KISS1 Gene

(1) OMIM Diseases for KISS1 Gene (603286)

UniProtKB/Swiss-Prot

KISS1_HUMAN
  • Hypogonadotropic hypogonadism 13 with or without anosmia (HH13) [MIM:614842]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). {ECO:0000269 PubMed:22335740}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for KISS1 Gene

(25) Novoseek inferred disease relationships for KISS1 Gene

Disease -log(P) Hits PubMed IDs
metastasis 63.8 89
klinefelters syndrome 53.2 1
puberty precocious 52.8 4
puberty delayed 51.4 2
hydatidiform mole 48.8 1

Relevant External Links for KISS1

Genetic Association Database (GAD)
KISS1
Human Genome Epidemiology (HuGE) Navigator
KISS1
genes like me logo Genes that share disorders with KISS1: view

Publications for KISS1 Gene

  1. Suppression of metastasis in human breast carcinoma MDA-MB-435 cells after transfection with the metastasis suppressor gene, KiSS-1. (PMID: 9192814) Lee J.-H. … Welch D.R. (Cancer Res. 1997) 2 3 4 23
  2. Chromosome localization and genomic structure of the KiSS-1 metastasis suppressor gene (KISS1). (PMID: 9806840) West A. … Weissman B.E. (Genomics 1998) 2 3 4 23
  3. KiSS-1 represses 92-kDa type IV collagenase expression by down- regulating NF-kappa B binding to the promoter as a consequence of IkappaBalpha-induced block of p65/p50 nuclear translocation. (PMID: 11060311) Yan C. … Boyd D.D. (J. Biol. Chem. 2001) 3 4 23
  4. Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G- protein-coupled receptor. (PMID: 11385580) Ohtaki T. … Fujino M. (Nature 2001) 3 4 23
  5. KiSS-1, a novel human malignant melanoma metastasis-suppressor gene. (PMID: 8944003) Lee J.-H. … Welch D.R. (J. Natl. Cancer Inst. 1996) 3 4 23

Products for KISS1 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate KISS1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for KISS1
  • Block miRNA regulation of KISS1 using miScript Target Protectors

Sources for KISS1 Gene

Back to Top

Content