 |
 | Services
| |
 |
Aliases &
Descriptions
for KISS1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| KiSS-1 2 | | Kisspeptin-1 3 | | METASTIN 2 | | MGC39258 2 | | OTTHUMP00000034312 2 | | kisspeptin 2 |
| | | Descriptions |
|---|
| KiSS-1 metastasis-suppressor 2 | | malignant melanoma metastasis-suppressor 2 |
|
| |
Search outside databases for aliases for KISS1 genePrevious GC identifers: GC01M201883 GC01M199620 GC01M200520 GC01M201336 GC01M200892 |
Summaries
for KISS1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for KISS1:
This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast
carcinomas without affecting tumorigenicity. The encoded protein may function to inhibit
chemotaxis and invasion, attenuating metastasis in malignant melanomas. Studies suggest a putative
role in the regulation of events downstream of cell-matrix adhesion, perhaps involving
cytoskeletal reorganization. A polymorphism in the terminal exon of this mRNA results in two
protein isoforms. An adenosine present at the polymorphic site represents the third position in a
stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded
protein extends for an additional seven amino acid residues. [provided by RefSeq]
UniProtKB/Swiss-Prot: KISS1_HUMAN, Q15726Function: Metastasis suppressor protein in malignant melanomas and in some breast cancers. May
regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization.
Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of
the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and
cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the
primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10,
but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester
trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion
generated by the trophoblast itself. The receptor is also essential for normal
gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a
pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthoodGene Wiki entry for KISS1 (Kisspeptin) |
Genomic Location
for KISS1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the KISS1 gene 
Entrez Gene cytogenetic band: 1q32 Ensembl cytogenetic band: 1q32.1 HGNC cytogenetic band: 1q32KISS1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M202426:
(about GC identifiers)
Start:
|
202,426,092 bp from pter |
End:
|
202,432,251 bp from pter |
Size:
|
6,160 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000001.9 NT_004487.18
| Proteins
for KISS1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: KISS1_HUMAN, Q15726 (See
protein sequence)Recommended Name: Metastasis-suppressor KiSS-1 precursor Size: 145 amino acids; 15332 Da
Subcellular location: Secreted
Secondary accessions: Q9HBP1Post-translational modifications:
Processed by MMP2 and MMP91
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_002247.3
ENSEMBL proteins: ENSP00000307650 ENSP00000356162
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
About this table
Antibodies for KISS1:
Assays for KISS1: | Protein
Domains/
Families
for KISS1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q15726 UniProtKB/Swiss-Prot: KISS1_HUMAN, Q15726Similarity: Belongs to the KISS1 family | Gene Function
for KISS1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002256
 Applied Biosystems Silencer® siRNAs for KISS1
 Sigma-Aldrich siRNA for KISS1
Sigma-Aldrich shRNA for KISS1
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_002256
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002256
untagged cDNA clone in CMV expression vector: NM_002256
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_002256
UniProtKB/Swiss-Prot: KISS1_HUMAN, Q15726Function: Metastasis suppressor protein in malignant melanomas and in some breast cancers. May
regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization.
Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of
the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and
cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the
primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10,
but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester
trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion
generated by the trophoblast itself. The receptor is also essential for normal
gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a
pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthoodInduction: Down-regulated during the progression of melanoma in vivo. Diminishes MMP9 expression by
effecting reduced NF-kappa-B binding to the promoterGenatlas biochemistry entry for KISS1:KISS1 metastasis suppressor in malignant melonoma,and at least in some human breast cancers7 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Kiss1):
1 Gene Ontology (GO) molecular function term (links to tree view): About this table | Pathways & Interactions
for KISS1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for KISS1
5/8 Interacting proteins for KISS1 (ENSP000003076503) via UniProtKB, MINT, and/or STRING (see all 8
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007010 | cytoskeleton organization |
TAS | 9192814 |
About this table
|
Drugs & Compounds
for KISS1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for KISS1
5  Novoseek chemical compound relationships for KISS1 gene
About this table
|
Transcripts
for KISS1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002256
Sigma-Aldrich siRNA for KISS1
Sigma-Aldrich shRNA for KISS1
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_002256 REFSEQ mRNAs for KISS1 gene: NM_002256.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_002256
OriGene GFP tagged cDNA clone in CMV expression vector: NM_002256
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002256
untagged cDNA clone in CMV expression vector: NM_002256
Additional cDNA sequence: AF218017.1 AK291695.1 AY117143.1 BC022819.1 CR594921.1 CR603087.1 CR609203.1 CR618718.1 CR622101.1 CR625917.1 U43527.1 6 DOTS entries: DT.453148 DT.97862005 DT.85104708 DT.216804 DT.97862006 DT.91961398 24/335 AceView cDNA sequences (see all 335
):CR625917 BC022819 AW239474 CR594921 CR609203 BM911628 CR618718 CR603087 BU751872 AF218017 CR622101 BX351793 R75765 AA460851 BU751906 BM911594 BQ007307 BQ011226 BX459219 AA461159 AY117143 BM915463 CF530093 BU726501
 highest scoring ESTs for KISS1:U43527 AA449043 AA452684 AF218017 AW239474 BC022819 BM691149 BM915081 BM915309 BM915463 Unigene Cluster for KISS1: KiSS-1 metastasis-suppressor Hs.95008 [show with all ESTs]Unigene Representative Sequence: BM807845
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for KISS1
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b |
|---|
|
| SP1: | | | | | | | | | | | |
| SP2: | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for KISS1
2 Ensembl transcripts including schematic representations: ENST00000306118
ENST00000367194
|
Expression
for KISS1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| KISS1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for KISS1
1 / 2 / 3 3 probe-sets matching KISS1 gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: CGGGGCGGGG
SOURCE GeneReport for Unigene cluster: Hs.95008
Expression variation in blood from EXPOLDB for KISS1 UniProtKB/Swiss-Prot: KISS1_HUMAN, Q15726Tissue specificity: Very high expression in placenta, with the next highest level in testis and
moderate levels in pancreas, liver, small intestine and brain at much lower levels. Expression
levels increased in both early placentas and molar pregnancies and are reduced in choriocarcinoma
cells. Expressed at higher levels in first trimester trophoblasts than at term of gestation, but
only expressed in the villous trophoblast |
Orthologs
for KISS1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for KISS1 gene from 4 species
About this table Species with no ortholog for KISS1
ENSEMBL Gene Tree for KISS1 | Paralogs
for KISS1(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| -- |
SNPs/Variants
for KISS1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for KISS1 (up to first 250kb)
|
Disorders & Mutations
for KISS1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 603286
10/23 Novoseek disease relationships for KISS1 gene (see all 23
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| metastasis |
63.07 |
99 |
9192814 (4), 16964286 (4), 17312308 (4), 18844032 (4) (see all 50) |
| hydatidiform mole |
51.89 |
1 |
15949403 (1) |
| melanoma |
49.71 |
28 |
8944003 (5), 9192814 (2), 9185708 (1), 11385580 (1) (see all 19) |
| klinefelters syndrome |
49.22 |
1 |
17486693 (1) |
| puberty delayed |
43.78 |
1 |
15598687 (1) |
| puberty precocious |
42.36 |
3 |
17609410 (2), 19138897 (1) |
| tumors |
32.18 |
66 |
12547718 (4), 17914099 (3), 14977840 (3), 17312308 (3) (see all 25) |
| nonmetastatic |
29.31 |
3 |
8944003 (2), 16288036 (1) |
| preeclampsia |
29.18 |
24 |
16202310 (8), 17083831 (4), 15949403 (2) |
| metastatic melanoma |
28.74 |
5 |
16964286 (2), 16288036 (1), 8944003 (1) |
About this table
Human Gene Mutation Database: KISS1
Human Genome Epidemiology Navigator: KISS1 (2 documents)
|
Medical News
for KISS1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for KISS1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/144 PubMed articles for KISS1 gene (see all 144
):- Suppression of metastasis in human breast carcinoma MDA-MB-435 cells after transfection with the metastasis suppressor gene, KiSS-1. (PubMed id 9192814)1, 2, 3, 4 Lee J.-H. and Welch D.R. (1997)
- Chromosome localization and genomic structure of the KiSS-1 metastasis suppressor gene (KISS1). (PubMed id 9806840)1, 2, 3, 4 West A....Weissman B.E. (1998)
- Tumor suppressor role of KiSS-1 in bladder cancer: loss of KiSS-1 expression is associated with bladder cancer progression and clinical outcome. (PubMed id 12547718)1, 3, 4 Sanchez-Carbayo M.... Cordon-Cardo C. (2003)
- Dramatic elevation of plasma metastin concentrations in human pregnancy: metastin as a novel placenta-derived hormone in humans. (PubMed id 12574233)1, 3, 4 Horikoshi Y.... Fujino M. (2003)
- KiSS-1 represses 92-kDa type IV collagenase expression by down- regulating NF-kappa B binding to the promoter as a consequence of IkappaBalpha-induced block of p65/p50 nuclear translocation. (PubMed id 11060311)1, 3, 4 Yan C.... Boyd D.D. (2001)
- Clinical significance of the loss of KiSS-1 and orphan G-protein- coupled receptor (hOT7T175) gene expression in esophageal squamous cell carcinoma. (PubMed id 14977840)1, 3, 4 Ikeguchi M.... Kaibara N. (2004)
- Downregulation of KiSS-1 expression is responsible for tumor invasion and worse prognosis in gastric carcinoma. (PubMed id 15300798)1, 3, 4 Dhar D.K.... Nagasue N. (2004)
- Quantitative reverse transcriptase polymerase chain reaction analysis for KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in hepatocellular carcinoma. (PubMed id 12898236)1, 3, 4 Ikeguchi M.... Kaibara N. (2003)
- Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases. (PubMed id 12879005)1, 3, 4 Takino T.... Sato H. (2003)
- KiSS-1, a novel human malignant melanoma metastasis-suppressor gene. (PubMed id 8944003)1, 3, 4 Lee J.-H.... Welch D.R. (1996)
|
Search for KISS1
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KISS1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing KISS1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KISS1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| About This Section
| --
| Services
for KISS1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for KISS1:
 | |
 | | | | |
 |
 |  |  | |
| | |  | Search Tocris compounds for KISS1 |
|
 |
 | | |
|
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|
V3 here soon-try beta now
