KISS1 Gene
protein-coding GIFtS : 60 GCID: GC01 M204159
KiSS-1 metastasis-suppressor
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Aliasesfor KISS1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases KiSS-1 Metastasis-Suppressor 1 2 Malignant Melanoma Metastasis-Suppressor2 HH132 Metastasis-Suppressor KiSS-12 KiSS-12 Metastin1 Kisspeptin-13 Kisspeptin-13
Export aliases for KISS1 gene to outside databases Previous GC identifers: GC01M201883 GC01M199620 GC01M200520 GC01M201336 GC01M200892 GC01M202426 GC01M175324
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Summariesfor KISS1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for KISS1 : This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH nuerons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues. (provided by RefSeq, Mar 2012) UniProtKB/Swiss-Prot: KISS1_HUMAN, Q15726 Function : Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate eventsdownstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood Gene Wiki entry for KISS1 (Kisspeptin)
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Genomic Viewsfor KISS1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NC_018912.1 NT_004487.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the KISS1 gene promoter:Sp1 AP-2alpha isoform 3 AP-2alpha isoform 2 E2F-1 E2F AP-2alpha isoform 4 AP-2alpha ATF AP-2alphaA Other transcription factors Search SABiosciences Chromatin IP Primers for KISS1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KISS1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1q32 Ensembl cytogenetic band: 1q32.1 HGNC cytogenetic band: 1q32 KISS1 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01M204159: view genomic region
(about GC identifiers )
Start: 204,159,469 bp from pter End:
204,165,619 bp from pter
Size: 6,151 bases Orientation:
minus strand
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Proteinsfor KISS1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: KISS1_HUMAN, Q15726 See
protein sequence )Recommended Name: Size : 138 amino acids; 14705 DaSubcellular location : SecretedSequence caution : Sequence=AAC79512.1; Type=Frameshift; Positions=138; Sequence=AAM78592.1; Type=Frameshift;Positions=138;
Secondary accessions : A8K6N0 Q9HBP1Explore the universe of human proteins at neXtProt for KISS1: NX_Q15726 Post-translational modifications:
Processed by MMP2 and MMP91 View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q15726 KISS1 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_002247.3 ENSEMBL proteins: ENSP00000356162 Reactome Protein details: Q15726 Human Recombinant Protein Products: Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6 ): About this table
About GeneDecksing KISS1 Antibody Products: Assay Products for KISS1:
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Protein
Domains /for KISS1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q15726 ProtoNet protein and cluster: Q15726
UniProtKB/Swiss-Prot: KISS1_HUMAN, Q15726 Similarity : Belongs to the KISS1 family
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Functionfor KISS1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: KISS1_HUMAN, Q15726 Function : Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate eventsdownstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood Induction : Down-regulated during the progression of melanoma in vivo. Diminishes MMP9 expression by effecting reducedNF-kappa-B binding to the promoter
Genatlas biochemistry entry for KISS1 KISS1 metastasis suppressor in malignant melonoma,and at least in some human breast cancers Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: KISS1 (NM_002256 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KISS1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat KISS1
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
About GeneDecksing 1 GenomeRNAi human phenotype for KISS1 :Animal Models: Kiss1 tm1Rla for KISS111 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Kiss1) :About GeneDecksing
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Pathways & Interactionsfor KISS1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways About this table See pathways by source Super-pathway contained gene-specific pathways 1 Class A/1 (Rhodopsin-like receptors) 2 Signaling by GPCR 3 G alpha (q) signalling events 4 Selected targets of ESR1 5 Selected targets of CREB1
Pathway sources See GeneCards unified pathways Show all pathways 2 5/8 (see all 8 )About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KISS1 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/128 Interacting proteins for KISS1 (Q15726 3 ENSP00000356162 4 via UniProtKB, MINT, STRING , and/or I2D (see all 128 )About this table Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0007010 cytoskeleton organization
TAS 9192814 GO:0007186 G-protein coupled receptor signaling pathway
-- -- GO:0008285 negative regulation of cell proliferation
IEA -- GO:0033686 positive regulation of luteinizing hormone secretion
IEA -- GO:0043410 positive regulation of MAPK cascade
IEA --
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Drugs & Compoundsfor KISS1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for KISS1 9 Novoseek chemical compound relationships for KISS1 gene About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
gnrh
80.8
62
17988212 (4), 20389100 (3), 15684075 (3), 18940206 (2) (see all 28 )
testosterone
36.2
15
18940206 (2), 16629833 (2), 20022159 (2), 16650418 (1) (see all 7 )
glyceraldehyde 3-phosphate
31.1
4
14977840 (1), 17442564 (1), 19331211 (1), 12898236 (1)
steroid
25.5
7
17185374 (2), 17656465 (1)
estrogen
18.6
8
17914099 (2), 17656465 (2), 18614256 (1), 20019906 (1)
progesterone
12
3
17185374 (3), 19141682 (1), 20078960 (1)
glucose
0
7
16826407 (2), 20078960 (2), 16650418 (1), 20022159 (1)
calcium
0
2
16222076 (2)
alanine
0
1
16242330 (1)
KISS1
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Transcriptsfor KISS1 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for KISS1 gene: NM_002256.3 Unigene Cluster for KISS1:
KiSS-1 metastasis-suppressor Hs.95008 [show with all ESTs ] Unigene Representative Sequence: BM807845 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000367194 (uc001har.3 ) Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: KISS1 (NM_002256 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KISS1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat KISS1
Additional cDNA sequence: AF218017.1 AK291695.1 AY117143.1 BC022819.1 U43527.1
6 DOTS entries : DT.453148 DT.97862005
DT.85104708 DT.216804 DT.97862006 DT.91961398 24/335 AceView cDNA sequences (see all 335 ):
BM911628 CR625917 CR622101 BU751872 BX351793 CR609203 CR594921 AA460851 AW239474 R75765 CR603087 CR618718 BC022819 AF218017 BF055498 BU726501 CB993448 CB998059 BQ026605 BQ011226 BU751800 CB992552 CB990142 BM915463 GeneLoc Exon Structure 2 Alternative Splicing Database (ASD) splice patterns (SP) for KISS1 About this scheme ExUns: 1a · 1b ^ 2 ^ 3a · 3b SP1 : SP2 :
ECgene alternative splicing isoforms for KISS1
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Expression for KISS1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section KISS1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CGGGGCGGGG
About this image KISS1 expression in embryonic tissues and stem cells About this table See KISS1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for KISS1 SOURCE GeneReport for Unigene cluster: Hs.95008 UniProtKB/Swiss-Prot: KISS1_HUMAN, Q15726 Tissue specificity : Very high expression in placenta, with the next highest level in testis and moderate levels inpancreas, liver, small intestine and brain at much lower levels. Expression levels increased in both early placentas and molar pregnancies and are reduced in choriocarcinoma cells. Expressed at higher levels in first trimester trophoblasts than at term of gestation, but only expressed in the villous trophoblast SABiosciences Expression via Pathway-Focused PCR Array including KISS1 : Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat
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Orthologsfor KISS1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for KISS1 gene from 1/6 species (see all 6 ) About this table
ENSEMBL Gene Tree for KISS1 (if available)TreeFam Gene Tree for KISS1 (if available)
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Paralogsfor KISS1 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section
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Genomic Variantsfor KISS1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 1 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for KISS1 (204159469 - 204165619 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for KISS1 1 Indel 97616 Human Gene Mutation Database (HGMD) : KISS1 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor KISS1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 603286
OMIM disorders : --20/48 (see all 48 ): About MalaCards melanoma breast carcinoma melanoma metastasis carcinoma down syndrome critical region pre-eclampsia precocious puberty delayed puberty klinefelter's syndrome gastric cardia carcinoma polycystic ovary syndrome esophageal squamous cell carcinoma squamous cell carcinoma kallmann syndrome transitional cell carcinoma down syndrome hypogonadism epithelial ovarian cancer pituitary adenoma insulin resistance 1 disease from the University of Copenhagen DISEASES database for KISS1 :Klinefelter's syndrome 10/25 Novoseek disease relationships for KISS1 gene (see all 25 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
metastasis
63.8
120
19645016 (6), 9192814 (4), 18844032 (4), 17312308 (4) (see all 57 )
klinefelters syndrome
53.2
1
17486693 (1)
puberty precocious
52.8
4
17609410 (2), 20389100 (1), 19138897 (1)
puberty delayed
51.4
2
15598687 (1), 19228890 (1)
hydatidiform mole
48.8
1
15949403 (1)
melanoma
47.6
29
8944003 (5), 9192814 (2), 9185708 (1), 11385580 (1) (see all 20 )
hypogonadism
44.7
1
19554077 (1)
tumors
32.9
80
19895172 (5), 12547718 (4), 17914099 (3), 14977840 (3) (see all 29 )
cancer
31.4
28
16260418 (3), 16320113 (1), 18644415 (1), 19212644 (1) (see all 15 )
nonmetastatic
25.3
3
8944003 (2), 16288036 (1)
Human Genome Epidemiology (HuGE) Navigator: KISS1 (8 documents) Export disorders for KISS1 gene to outside databases
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Publicationsfor KISS1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for KISS1 gene, integrated from 9 sources (see all 233 ):(articles sorted by number of sources associating them with KISS1) Utopia : connect your pdf to the dynamic
Suppression of metastasis in human breast carcinoma MDA-MB-435 cells after transfection with the metastasis suppressor gene, KiSS-1. (PubMed id 9192814) 1 , 2 , 3, 9(1997) Chromosome localization and genomic structure of the KiSS-1 metastasis suppressor gene (KISS1). (PubMed id 9806840) 1 , 2 , 3, 9(1998) Tumor suppressor role of KiSS-1 in bladder cancer: loss of KiSS-1 expression is associated with bladder cancer progression and clinical outcome. (PubMed id 12547718) 1 , 2 , 9(2003) Dramatic elevation of plasma metastin concentrations in human pregnancy: metastin as a novel placenta-derived hormone in humans. (PubMed id 12574233) 1 , 2 , 9(2003) KiSS-1 represses 92-kDa type IV collagenase expression by down- regulating NF-kappa B binding to the promoter as a consequence of IkappaBalpha-induced block of p65/p50 nuclear translocation. (PubMed id 11060311) 1 , 2 , 9(2001) Clinical significance of the loss of KiSS-1 and orphan G-protein- coupled receptor (hOT7T175) gene expression in esophageal squamous cell carcinoma. (PubMed id 14977840) 1 , 2 , 9(2004) Downregulation of KiSS-1 expression is responsible for tumor invasion and worse prognosis in gastric carcinoma. (PubMed id 15300798) 1 , 2 , 9(2004) Quantitative reverse transcriptase polymerase chain reaction analysis for KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in hepatocellular carcinoma. (PubMed id 12898236) 1 , 2 , 9(2003) Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases. (PubMed id 12879005) 1 , 2 , 9(2003) KiSS-1, a novel human malignant melanoma metastasis-suppressor gene. (PubMed id 8944003) 1 , 2 , 9(1996)
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External Searches for KISS1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing KISS1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
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Other Databases showing KISS1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing KISS1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for KISS1 Pharmacogenomics, SNPs, Pathways ATLAS Chromosomes in Cancer entry for KISS1Genetics and Cytogenetics in Oncology and Haematology Protein Spotlight http://web.expasy.org/spotlight/back_issues/sptlt058.shtml
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About This Section Patent Information for KISS1 gene: KISS1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor KISS1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for KISS1 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for KISS1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for KISS1 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for KISS1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for KISS1 OriGene Custom Protein Services for KISS1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KISS1 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KISS1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Search Tocris compounds for KISS1
Recombinant Protein for KISS1
KISS1 Proteins, Antibodies, CLIAs, and ELISAs
Search ThermoFisher Antibodies for KISS1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat KISS1
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Browse Tocris compounds for 
Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Negative
Selective marker
Curated
In-situ hybridization
