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KISS1 Gene

protein-coding   GIFtS: 61
GCID: GC01M204159

KiSS-1 Metastasis-Suppressor

  See KISS1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
KiSS-1 Metastasis-Suppressor1 2     kisspeptin-12
prepro-kisspeptin1 2     Malignant Melanoma Metastasis-Suppressor2
HH132 5     Metastasis-Suppressor KiSS-12
kisspeptin1     metastin2
KiSS-12     Kisspeptin-13

External Ids:    HGNC: 63411   Entrez Gene: 38142   Ensembl: ENSG000001704987   OMIM: 6032865   UniProtKB: Q157263   

Export aliases for KISS1 gene to outside databases

Previous GC identifers: GC01M201883 GC01M199620 GC01M200520 GC01M201336 GC01M200892 GC01M202426 GC01M175324


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KISS1 Gene:
This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without
affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate
metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of
cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin,
stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal
activation of GnRH nuerons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An
adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is
absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid
residues. (provided by RefSeq, Mar 2012)

GeneCards Summary for KISS1 Gene:
KISS1 (KiSS-1 metastasis-suppressor) is a protein-coding gene. Diseases associated with KISS1 include kiss1-related isolated gonadotropin-releasing hormone deficiency, and gastric cardia carcinoma. GO annotations related to this gene include kisspeptin receptor binding.

UniProtKB/Swiss-Prot: KISS1_HUMAN, Q15726
Function: Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events
downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally
amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54.
Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor
metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium
of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in
isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast
invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released
hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation
of the gonadotropic axis at puberty and in adulthood

Gene Wiki entry for KISS1 (Kisspeptin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the KISS1 gene promoter:
         Sp1   AP-2alpha isoform 3   AP-2alpha isoform 2   E2F-1   E2F   AP-2alpha isoform 4   AP-2alpha   ATF   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKISS1 promoter sequence
   Search Chromatin IP Primers for KISS1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KISS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32

KISS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KISS1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M204159:  view genomic region     (about GC identifiers)

Start:
204,159,469 bp from pter      End:
204,165,619 bp from pter
Size:
6,151 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KISS1_HUMAN, Q15726 (See protein sequence)
Recommended Name: Metastasis-suppressor KiSS-1 precursor  
Size: 138 amino acids; 14705 Da
Sequence caution: Sequence=AAC79512.1; Type=Frameshift; Positions=138; Sequence=AAM78592.1; Type=Frameshift;
Positions=138;
Secondary accessions: A8K6N0 Q9HBP1

Explore the universe of human proteins at neXtProt for KISS1: NX_Q15726

Explore proteomics data for KISS1 at MOPED

Post-translational modifications: 

  • Processed by MMP2 and MMP91
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KISS1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002247.3  
    ENSEMBL proteins: 
     ENSP00000356162  
    Reactome Protein details: Q15726

    KISS1 Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for KISS1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    1 InterPro protein domain:
     IPR020207 Metastasis-suppressor_KiSS-1

    Graphical View of Domain Structure for InterPro Entry Q15726

    ProtoNet protein and cluster: Q15726

    UniProtKB/Swiss-Prot: KISS1_HUMAN, Q15726
    Similarity: Belongs to the KISS1 family


    Find genes that share domains with KISS1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KISS1_HUMAN, Q15726
    Function: Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events
    downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally
    amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54.
    Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor
    metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium
    of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in
    isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast
    invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released
    hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation
    of the gonadotropic axis at puberty and in adulthood
    Induction: Down-regulated during the progression of melanoma in vivo. Diminishes MMP9 expression by effecting
    reduced NF-kappa-B binding to the promoter

         Genatlas biochemistry entry for KISS1:
    KISS1 metastasis suppressor in malignant melonoma,and at least in some human breast cancers

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11387329
    GO:0031773kisspeptin receptor binding IEA--
         
    Find genes that share ontologies with KISS1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for KISS1:
     Decreased focal adhesion (FA)  

         12 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Kiss1):
     adipose tissue  digestive/alimentary  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism 
     integument  liver/biliary system  mortality/aging  nervous system  no phenotypic analysis 
     renal/urinary system  reproductive system 

    Find genes that share phenotypes with KISS1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Kiss1tm1Rla for KISS1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KISS1
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KISS1_HUMAN, Q15726: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2
    plasma membrane2
    cytosol1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0005737cytoplasm IEA--
    GO:0016324apical plasma membrane IEA--
    GO:0043005neuron projection IEA--

    Find genes that share ontologies with KISS1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KISS1 About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    2Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    3Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Selected targets of ESR1
    Selected targets of ESR1
    5Selected targets of CREB1
    Selected targets of CREB1


    Find genes that share SuperPaths with KISS1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for KISS1
        Peptide ligand-binding receptors
    G alpha (q) signalling events


        Pathway & Disease-focused RT2 Profiler PCR Array including KISS1: 
              Tumor Metastasis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for KISS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KISS1 (Q157263 ENSP000003561624) via UniProtKB, MINT, STRING, and/or I2D (see all 128)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KISS1RQ969F83, ENSP000002343714I2D: score=3 STRING: ENSP00000234371
    MMP14P502813, ENSP000003082084I2D: score=1 STRING: ENSP00000308208
    MMP2P082533, ENSP000002190704I2D: score=1 STRING: ENSP00000219070
    MMP16P515123, ENSP000002866144I2D: score=1 STRING: ENSP00000286614
    MMP9P147803, ENSP000003614054I2D: score=1 STRING: ENSP00000361405
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007010cytoskeleton organization TAS9192814
    GO:0007204positive regulation of cytosolic calcium ion concentration ----
    GO:0008285negative regulation of cell proliferation IEA--
    GO:0033686positive regulation of luteinizing hormone secretion IEA--
    GO:0043410positive regulation of MAPK cascade IEA--

    Find genes that share ontologies with KISS1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KISS1

    9 Novoseek inferred chemical compound relationships for KISS1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gnrh 80.8 62 17988212 (4), 20389100 (3), 15684075 (3), 18940206 (2) (see all 28)
    testosterone 36.2 15 18940206 (2), 16629833 (2), 20022159 (2), 16650418 (1) (see all 7)
    glyceraldehyde 3-phosphate 31.1 4 14977840 (1), 17442564 (1), 19331211 (1), 12898236 (1)
    steroid 25.5 7 17185374 (2), 17656465 (1)
    estrogen 18.6 8 17914099 (2), 17656465 (2), 18614256 (1), 20019906 (1)
    progesterone 12 3 17185374 (3), 19141682 (1), 20078960 (1)
    glucose 0 7 16826407 (2), 20078960 (2), 16650418 (1), 20022159 (1)
    calcium 0 2 16222076 (2)
    alanine 0 1 16242330 (1)



    Find genes that share compounds with KISS1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KISS1 gene: 
    NM_002256.3  

    Unigene Cluster for KISS1:

    KiSS-1 metastasis-suppressor
    Hs.95008  [show with all ESTs]
    Unigene Representative Sequence: BM807845
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000367194(uc001har.3)
    miRNA
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    Additional mRNA sequence: 

    AF218017.1 AK291695.1 AY117143.1 BC022819.1 U43527.1 

    6 DOTS entries:

    DT.453148  DT.97862005  DT.85104708  DT.216804  DT.97862006  DT.91961398 

    Selected AceView cDNA sequences (see all 335):

    AF218017 BC022819 BU751872 CR618718 AA460851 AW239474 BM911628 R75765 
    CR609203 CR603087 BX351793 CR622101 CR594921 CR625917 AL540406 AI288481 
    BQ007307 BM691149 BQ011271 BM915463 BF055498 CB998059 AW087912 T52080 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for KISS1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b
    SP1:                              
    SP2:                              


    ECgene alternative splicing isoforms for KISS1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KISS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGGGCGGGG
    KISS1 Expression
    About this image


    KISS1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Placenta (Extraembryonic Tissues)
    KISS1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KISS1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.95008

    UniProtKB/Swiss-Prot: KISS1_HUMAN, Q15726
    Tissue specificity: Very high expression in placenta, with the next highest level in testis and moderate levels in
    pancreas, liver, small intestine and brain at much lower levels. Expression levels increased in both early
    placentas and molar pregnancies and are reduced in choriocarcinoma cells. Expressed at higher levels in first
    trimester trophoblasts than at term of gestation, but only expressed in the villous trophoblast

        Pathway & Disease-focused RT2 Profiler PCR Array including KISS1: 
              Tumor Metastasis in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KISS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for KISS1 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kiss11 , 5 KiSS-1 metastasis-suppressor1, 5 70.11(n)1
    52.38(a)1
      1 (57.91 cM)5
    2802871  NM_178260.31  NP_839991.21 
     1333098275 


    ENSEMBL Gene Tree for KISS1 (if available)
    TreeFam Gene Tree for KISS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KISS1 (see all 234)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0691794
    Hypogonadotropic hypogonadism 13 with or without anosmia (HH13)4--see VAR_0691792 N K mis40--------
    rs57802191,2
    C--204166266(+) CAGCT-/TATGAG 1 -- us2k10--------
    rs1874423231,2
    --210696709(+) GTGATC/TGGCAT 1 -- int10--------
    rs1513354011,2
    C--210696776(+) TCCATC/TTCCCC 1 -- int10--------
    rs752062701,2
    F--210696816(+) AAAGTG/ATGGGC 1 -- int11Minor allele frequency- A:0.01WA 118
    rs347299721,2
    C--210696905(+) TTTTTA/GTAGAA 1 -- int15Minor allele frequency- G:0.20NA WA EA 362
    rs741394961,2
    C,F--210696923(+) ATCGCT/CGAAAC 1 -- int13Minor allele frequency- C:0.12WA CSA 121
    rs1927358511,2
    --210696944(+) CATACA/GGTTTG 1 -- int10--------
    rs1845799371,2
    --210697013(+) TTTTTA/TAAGTA 1 -- int10--------
    rs1894157961,2
    --210697020(+) AGTACC/TAATCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for KISS1 (204159469 - 204165619 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KISS1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2721829CNV Deletion23290073
    esv2627051CNV Insertion19546169
    nsv528249CNV Loss19592680

    Human Gene Mutation Database (HGMD): KISS1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KISS1
    DNA2.0 Custom Variant and Variant Library Synthesis for KISS1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603286   
    OMIM disorders: 614842  
    UniProtKB/Swiss-Prot: KISS1_HUMAN, Q15726
  • Hypogonadotropic hypogonadism 13 with or without anosmia (HH13) [MIM:614842]: A disorder characterized by
    absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating
    gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it
    is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss.
    Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is
    due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of
    gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic
    hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been
    termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 8 diseases for KISS1:    
    About MalaCards
    kiss1-related isolated gonadotropin-releasing hormone deficiency    gastric cardia carcinoma    hypogonadotropic hypogonadism 13 with or without anosmia    idiopathic central precocious puberty
    hypothalamic hamartomas    central precocious puberty    hypogonadotropic hypogonadism 17 with or without anosmia    pancreatic cancer

    1 disease from the University of Copenhagen DISEASES database for KISS1:
    Klinefelter's syndrome

    Find genes that share disorders with KISS1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for KISS1 gene (see all 25)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 63.8 120 19645016 (6), 9192814 (4), 18844032 (4), 17312308 (4) (see all 57)
    klinefelters syndrome 53.2 1 17486693 (1)
    puberty precocious 52.8 4 17609410 (2), 20389100 (1), 19138897 (1)
    puberty delayed 51.4 2 15598687 (1), 19228890 (1)
    hydatidiform mole 48.8 1 15949403 (1)
    melanoma 47.6 29 8944003 (5), 9192814 (2), 9185708 (1), 11385580 (1) (see all 20)
    hypogonadism 44.7 1 19554077 (1)
    tumors 32.9 80 19895172 (5), 12547718 (4), 17914099 (3), 14977840 (3) (see all 29)
    cancer 31.4 28 16260418 (3), 16320113 (1), 18644415 (1), 19212644 (1) (see all 15)
    nonmetastatic 25.3 3 8944003 (2), 16288036 (1)

    Genetic Association Database (GAD): KISS1
    Human Genome Epidemiology (HuGE) Navigator: KISS1 (8 documents)

    Export disorders for KISS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KISS1 gene, integrated from 10 sources (see all 267):
    (articles sorted by number of sources associating them with KISS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Suppression of metastasis in human breast carcinoma MDA-MB-435 cells after transfection with the metastasis suppressor gene, KiSS-1. (PubMed id 9192814)1, 2, 3, 9 Lee J.-H. and Welch D.R. (Cancer Res. 1997)
    2. Chromosome localization and genomic structure of the KiSS-1 metastasis suppressor gene (KISS1). (PubMed id 9806840)1, 2, 3, 9 West A.... Weissman B.E. (Genomics 1998)
    3. Tumor suppressor role of KiSS-1 in bladder cancer: loss of KiSS-1 expression is associated with bladder cancer progression and clinical outcome. (PubMed id 12547718)1, 2, 9 Sanchez-Carbayo M.... Cordon-Cardo C. (Am. J. Pathol. 2003)
    4. Dramatic elevation of plasma metastin concentrations in human pregnancy: metastin as a novel placenta-derived hormone in humans. (PubMed id 12574233)1, 2, 9 Horikoshi Y.... Fujino M. (J. Clin. Endocrinol. Metab. 2003)
    5. KiSS-1 represses 92-kDa type IV collagenase expression by down- regulating NF-kappa B binding to the promoter as a consequence of IkappaBalpha-induced block of p65/p50 nuclear translocation. (PubMed id 11060311)1, 2, 9 Yan C.... Boyd D.D. (J. Biol. Chem. 2001)
    6. A twisted kiss: in vitro and in vivo evidence of genetic variation and suppressed transcription of the metastasis-suppressor gene KiSS1 in early breast cancer. (PubMed id 19895172)1, 4, 9 Pentheroudakis G....Pavlidis N. (Neoplasma 2010)
    7. Downregulation of KiSS-1 expression is responsible for tumor invasion and worse prognosis in gastric carcinoma. (PubMed id 15300798)1, 2, 9 Dhar D.K.... Nagasue N. (Int. J. Cancer 2004)
    8. Clinical significance of the loss of KiSS-1 and orphan G-protein- coupled receptor (hOT7T175) gene expression in esophageal squamous cell carcinoma. (PubMed id 14977840)1, 2, 9 Ikeguchi M.... Kaibara N. (Clin. Cancer Res. 2004)
    9. Quantitative reverse transcriptase polymerase chain reaction analysis for KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in hepatocellular carcinoma. (PubMed id 12898236)1, 2, 9 Ikeguchi M.... Kaibara N. (J. Cancer Res. Clin. Oncol. 2003)
    10. Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases. (PubMed id 12879005)1, 2, 9 Takino T.... Sato H. (Oncogene 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 3814 HGNC: 6341 AceView: KISS1 Ensembl:ENSG00000170498 euGenes: HUgn3814
    ECgene: KISS1 H-InvDB: KISS1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KISS1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KISS1 Genetics and Cytogenetics in Oncology and Haematology
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/058

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KISS1 gene:
    Search GeneIP for patents involving KISS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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