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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KISS1 Gene

protein-coding   GIFtS: 62
GCID: GC01M204159

KiSS-1 Metastasis-Suppressor

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
KiSS-1 Metastasis-Suppressor1 2     kisspeptin-12
prepro-kisspeptin1 2     Malignant Melanoma Metastasis-Suppressor2
kisspeptin1     Metastasis-Suppressor KiSS-12
HH132     metastin2
KiSS-12     Kisspeptin-13

External Ids:    HGNC: 63411   Entrez Gene: 38142   Ensembl: ENSG000001704987   OMIM: 6032865   UniProtKB: Q157263   

Export aliases for KISS1 gene to outside databases

Previous GC identifers: GC01M201883 GC01M199620 GC01M200520 GC01M201336 GC01M200892 GC01M202426 GC01M175324


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KISS1 Gene:
This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without
affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate
metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of
cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin,
stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal
activation of GnRH nuerons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An
adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is
absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid
residues. (provided by RefSeq, Mar 2012)

GeneCards Summary for KISS1 Gene: 
KISS1 (KiSS-1 metastasis-suppressor) is a protein-coding gene. Diseases associated with KISS1 include gastric cardia carcinoma, and idiopathic central precocious puberty, and among its related super-pathways are Signaling by GPCR and GPCR ligand binding. GO annotations related to this gene include kisspeptin receptor binding and protein binding.

UniProtKB/Swiss-Prot: KISS1_HUMAN, Q15726
Function: Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events
downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally
amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54.
Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor
metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium
of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in
isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast
invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released
hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation
of the gonadotropic axis at puberty and in adulthood

Gene Wiki entry for KISS1 (Kisspeptin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KISS1 gene promoter:
         Sp1   AP-2alpha isoform 3   AP-2alpha isoform 2   E2F-1   E2F   AP-2alpha isoform 4   AP-2alpha   ATF   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKISS1 promoter sequence
   Search SABiosciences Chromatin IP Primers for KISS1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KISS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32

KISS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KISS1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M204159:  view genomic region     (about GC identifiers)

Start:
204,159,469 bp from pter      End:
204,165,619 bp from pter
Size:
6,151 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KISS1_HUMAN, Q15726 (See protein sequence)
Recommended Name: Metastasis-suppressor KiSS-1 precursor  
Size: 138 amino acids; 14705 Da
Subcellular location: Secreted
Sequence caution: Sequence=AAC79512.1; Type=Frameshift; Positions=138; Sequence=AAM78592.1; Type=Frameshift;
Positions=138;
Secondary accessions: A8K6N0 Q9HBP1

Explore the universe of human proteins at neXtProt for KISS1: NX_Q15726

Explore proteomics data for KISS1 at MOPED 

Post-translational modifications:

  • UniProtKB: Processed by MMP2 and MMP9
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15726

  • KISS1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KISS1 Protein Expression
    REFSEQ proteins: NP_002247.3  
    ENSEMBL proteins: 
     ENSP00000356162  
    Reactome Protein details: Q15726
    Human Recombinant Protein Products for KISS1: 
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    Novus Biologicals KISS1 Proteins
    Novus Biologicals KISS1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for KISS1
    Cloud-Clone Corp. Proteins for KISS1 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0005737cytoplasm IEA--
    GO:0016324apical plasma membrane IEA--
    GO:0043005neuron projection IEA--

    KISS1 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for KISS1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR020207 Metastasis-suppressor_KiSS-1

    Graphical View of Domain Structure for InterPro Entry Q15726

    ProtoNet protein and cluster: Q15726

    UniProtKB/Swiss-Prot: KISS1_HUMAN, Q15726
    Similarity: Belongs to the KISS1 family


    KISS1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KISS1_HUMAN, Q15726
    Function: Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events
    downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally
    amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54.
    Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor
    metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium
    of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in
    isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast
    invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released
    hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation
    of the gonadotropic axis at puberty and in adulthood
    Induction: Down-regulated during the progression of melanoma in vivo. Diminishes MMP9 expression by effecting
    reduced NF-kappa-B binding to the promoter

         Genatlas biochemistry entry for KISS1:
    KISS1 metastasis suppressor in malignant melonoma,and at least in some human breast cancers

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11387329
    GO:0031773kisspeptin receptor binding IEA--
         
    KISS1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KISS1:
     Decreased focal adhesion (FA)  

         11 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Kiss1):
     digestive/alimentary  endocrine/exocrine gland  growth/size  homeostasis/metabolism  integument 
     liver/biliary system  mortality/aging  nervous system  no phenotypic analysis  renal/urinary system 
     reproductive system 

    KISS1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Kiss1tm1Rla for KISS1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for KISS1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KISS1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KISS1 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KISS1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    2Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    3G alpha (q) signalling events
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Selected targets of ESR1
    Selected targets of ESR1
    5Selected targets of CREB1
    Selected targets of CREB1

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for KISS1
        Selected targets of CREB1
    Selected targets of ESR1


    5/8        Reactome Pathways for KISS1 (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Gastrin-CREB signalling pathway via PKC and MAPK
    Signaling by GPCR
    GPCR ligand binding



    KISS1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KISS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/128 Interacting proteins for KISS1 (Q157263 ENSP000003561624) via UniProtKB, MINT, STRING, and/or I2D (see all 128)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KISS1RQ969F83, ENSP000002343714I2D: score=3 STRING: ENSP00000234371
    MMP14P502813, ENSP000003082084I2D: score=1 STRING: ENSP00000308208
    MMP2P082533, ENSP000002190704I2D: score=1 STRING: ENSP00000219070
    MMP16P515123, ENSP000002866144I2D: score=1 STRING: ENSP00000286614
    MMP9P147803, ENSP000003614054I2D: score=1 STRING: ENSP00000361405
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007010cytoskeleton organization TAS9192814
    GO:0007204elevation of cytosolic calcium ion concentration ----
    GO:0008285negative regulation of cell proliferation IEA--
    GO:0033686positive regulation of luteinizing hormone secretion IEA--
    GO:0043410positive regulation of MAPK cascade IEA--

    KISS1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KISS1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KISS1

    9 Novoseek inferred chemical compound relationships for KISS1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gnrh 80.8 62 17988212 (4), 20389100 (3), 15684075 (3), 18940206 (2) (see all 28)
    testosterone 36.2 15 18940206 (2), 16629833 (2), 20022159 (2), 16650418 (1) (see all 7)
    glyceraldehyde 3-phosphate 31.1 4 14977840 (1), 17442564 (1), 19331211 (1), 12898236 (1)
    steroid 25.5 7 17185374 (2), 17656465 (1)
    estrogen 18.6 8 17914099 (2), 17656465 (2), 18614256 (1), 20019906 (1)
    progesterone 12 3 17185374 (3), 19141682 (1), 20078960 (1)
    glucose 0 7 16826407 (2), 20078960 (2), 16650418 (1), 20022159 (1)
    calcium 0 2 16222076 (2)
    alanine 0 1 16242330 (1)

    Search CenterWatch for drugs/clinical trials and news about KISS1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KISS1 gene: 
    NM_002256.3  

    Unigene Cluster for KISS1:

    KiSS-1 metastasis-suppressor
    Hs.95008  [show with all ESTs]
    Unigene Representative Sequence: BM807845
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000367194(uc001har.3)
    miRNA
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    Additional mRNA sequence: 

    AF218017.1 AK291695.1 AY117143.1 BC022819.1 U43527.1 

    6 DOTS entries:

    DT.453148  DT.97862005  DT.85104708  DT.216804  DT.97862006  DT.91961398 

    24/335 AceView cDNA sequences (see all 335):

    CR618718 BC022819 AF218017 CR594921 CR603087 CR622101 R75765 BX351793 
    AW239474 CR625917 AA460851 BM911628 BU751872 CR609203 NM_002256 T49695 
    AI149521 BM911594 CF530126 CB993448 BU726501 BQ011226 BQ011265 BX459219 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for KISS1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b
    SP1:                              
    SP2:                              


    ECgene alternative splicing isoforms for KISS1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KISS1 expression in normal human tissues (normalized intensities)      KISS1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGGGCGGGG
    KISS1 Expression
    About this image


    KISS1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/24 selected tissues (see all 24) fully expand
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             testis ; cells in seminiferus ducts   
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             placenta ; trophoblastic cells   
             placenta   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
             colon ; peripheral nerve/ganglion   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 2 entries
             Human Schwann Cells (HSC)   
     
     Uncategorized (Uncategorized)    fully expand to see all 2 entries
             PureStem Progenitor W10

    See KISS1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KISS1

    SOURCE GeneReport for Unigene cluster: Hs.95008

    UniProtKB/Swiss-Prot: KISS1_HUMAN, Q15726
    Tissue specificity: Very high expression in placenta, with the next highest level in testis and moderate levels in
    pancreas, liver, small intestine and brain at much lower levels. Expression levels increased in both early
    placentas and molar pregnancies and are reduced in choriocarcinoma cells. Expressed at higher levels in first
    trimester trophoblasts than at term of gestation, but only expressed in the villous trophoblast

        SABiosciences Expression via Pathway-Focused PCR Array including KISS1: 
              Tumor Metastasis in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for KISS1 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kiss11 , 5 KiSS-1 metastasis-suppressor1, 5 71.43(n)1
    52.38(a)1
      1 (57.91 cM)5
    2802871  NM_178260.31  NP_839991.21 
     1333272125 


    ENSEMBL Gene Tree for KISS1 (if available)
    TreeFam Gene Tree for KISS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/234 SNPs in KISS1 are shown (see all 234)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0691794
    Hypogonadotropic hypogonadism 13 with or without anosmia (HH13)4--see VAR_0691792 N K mis40--------
    rs57802191,2
    C--204166266(+) CAGCT-/TATGAG 1 -- us2k10--------
    rs1874423231,2
    --210696709(+) GTGATC/TGGCAT 1 -- int10--------
    rs1513354011,2
    C--210696776(+) TCCATC/TTCCCC 1 -- int10--------
    rs752062701,2
    F--210696816(+) AAAGTG/ATGGGC 1 -- int11Minor allele frequency- A:0.01WA 118
    rs347299721,2
    C--210696905(+) TTTTTA/GTAGAA 1 -- int15Minor allele frequency- G:0.20NA WA EA 362
    rs741394961,2
    C,F--210696923(+) ATCGCT/CGAAAC 1 -- int13Minor allele frequency- C:0.12WA CSA 121
    rs1927358511,2
    --210696944(+) CATACA/GGTTTG 1 -- int10--------
    rs1845799371,2
    --210697013(+) TTTTTA/TAAGTA 1 -- int10--------
    rs1894157961,2
    --210697020(+) AGTACC/TAATCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for KISS1 (204159469 - 204165619 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KISS1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2721829CNV Deletion23290073
    esv2627051CNV Insertion19546169
    nsv528249CNV Loss19592680


    Human Gene Mutation Database (HGMD): KISS1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KISS1
    DNA2.0 Custom Variant and Variant Library Synthesis for KISS1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603286    OMIM disorders: --

    UniProtKB/Swiss-Prot: KISS1_HUMAN, Q15726
  • Hypogonadotropic hypogonadism 13 with or without anosmia (HH13) [MIM:614842]: A disorder characterized by
    absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating
    gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it
    is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss.
    Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is
    due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of
    gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic
    hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been
    termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 20/46 diseases for KISS1 (see all 46):    About MalaCards
    gastric cardia carcinoma    idiopathic central precocious puberty    hypogonadotropic hypogonadism 13 with or without anosmia    central precocious puberty
    melanoma    down syndrome critical region    klinefelter's syndrome    precocious puberty
    hypogonadotropism    hypogonadism    thyroid cancer    kallmann syndrome
    stomach cancer    choriocarcinoma    pre-eclampsia    eclampsia
    down syndrome    polycystic ovary syndrome    transitional cell carcinoma    pancreatic cancer

    1 disease from the University of Copenhagen DISEASES database for KISS1:
    Klinefelter's syndrome

    KISS1 for disorders           About GeneDecksing

    10/25 Novoseek inferred disease relationships for KISS1 gene (see all 25)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 63.8 120 19645016 (6), 9192814 (4), 18844032 (4), 17312308 (4) (see all 57)
    klinefelters syndrome 53.2 1 17486693 (1)
    puberty precocious 52.8 4 17609410 (2), 20389100 (1), 19138897 (1)
    puberty delayed 51.4 2 15598687 (1), 19228890 (1)
    hydatidiform mole 48.8 1 15949403 (1)
    melanoma 47.6 29 8944003 (5), 9192814 (2), 9185708 (1), 11385580 (1) (see all 20)
    hypogonadism 44.7 1 19554077 (1)
    tumors 32.9 80 19895172 (5), 12547718 (4), 17914099 (3), 14977840 (3) (see all 29)
    cancer 31.4 28 16260418 (3), 16320113 (1), 18644415 (1), 19212644 (1) (see all 15)
    nonmetastatic 25.3 3 8944003 (2), 16288036 (1)

    Genetic Association Database (GAD): KISS1
    Human Genome Epidemiology (HuGE) Navigator: KISS1 (8 documents)

    Export disorders for KISS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KISS1 gene, integrated from 9 sources (see all 259):
    (articles sorted by number of sources associating them with KISS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Suppression of metastasis in human breast carcinoma MDA-MB-435 cells after transfection with the metastasis suppressor gene, KiSS-1. (PubMed id 9192814)1, 2, 3, 9 Lee J.-H. and Welch D.R. (1997)
    2. Chromosome localization and genomic structure of the KiSS-1 metastasis suppressor gene (KISS1). (PubMed id 9806840)1, 2, 3, 9 West A.... Weissman B.E. (1998)
    3. Tumor suppressor role of KiSS-1 in bladder cancer: loss of KiSS-1 expression is associated with bladder cancer progression and clinical outcome. (PubMed id 12547718)1, 2, 9 Sanchez-Carbayo M.... Cordon-Cardo C. (2003)
    4. Dramatic elevation of plasma metastin concentrations in human pregnancy: metastin as a novel placenta-derived hormone in humans. (PubMed id 12574233)1, 2, 9 Horikoshi Y.... Fujino M. (2003)
    5. KiSS-1 represses 92-kDa type IV collagenase expression by down- regulating NF-kappa B binding to the promoter as a consequence of IkappaBalpha-induced block of p65/p50 nuclear translocation. (PubMed id 11060311)1, 2, 9 Yan C.... Boyd D.D. (2001)
    6. A twisted kiss: in vitro and in vivo evidence of gene tic variation and suppressed transcription of the metastasis-suppressor gene Ki SS1 in early breast cancer. (PubMed id 19895172)1, 4, 9 Pentheroudakis G....Pavlidis N. (2010)
    7. Downregulation of KiSS-1 expression is responsible for tumor invasion and worse prognosis in gastric carcinoma. (PubMed id 15300798)1, 2, 9 Dhar D.K.... Nagasue N. (2004)
    8. Clinical significance of the loss of KiSS-1 and orphan G-protein- coupled receptor (hOT7T175) gene expression in esophageal squamous cell carcinoma. (PubMed id 14977840)1, 2, 9 Ikeguchi M.... Kaibara N. (2004)
    9. Quantitative reverse transcriptase polymerase chain reaction analysis for KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in hepatocellular carcinoma. (PubMed id 12898236)1, 2, 9 Ikeguchi M.... Kaibara N. (2003)
    10. Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases. (PubMed id 12879005)1, 2, 9 Takino T.... Sato H. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3814 HGNC: 6341 AceView: KISS1 Ensembl:ENSG00000170498 euGenes: HUgn3814
    ECgene: KISS1 H-InvDB: KISS1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KISS1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KISS1 Genetics and Cytogenetics in Oncology and Haematology
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/sptlt058.shtml

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KISS1 gene:
    Search GeneIP for patents involving KISS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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