KIRREL2 Gene

Aliases
for KIRREL2 gene

Previous GC identifers: GC00U991236 GC19P041023 GC19P041039 GC19P041038 GC19P032853

Summaries
for KIRREL2 gene

Genomic Views
for KIRREL2 gene

RefSeq DNA sequence:

NC_000019.9  NC_018930.1  NT_011109.16  

SwitchGear Promoter luciferase reporter plasmid: KIRREL2 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIRREL2

KIRREL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P036347:  view genomic region     (about GC identifiers)

Proteins
for KIRREL2 gene

Explore the universe of human proteins at neXtProt for KIRREL2: NX_Q6UWL6

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for KIRREL2 (Kirrel2/NEPH3)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 2): KIRREL2 OriGene Custom Protein Services for KIRREL2
	GenScript Custom Purified and Recombinant Proteins Services for KIRREL2
	Novus Biologicals KIRREL2 Protein Novus Biologicals KIRREL2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for KIRREL2

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for KIRREL2 (Kirrel2/NEPH3)
	Browse OriGene Antibodies OriGene Custom Antibody Services for KIRREL2
	GenScript Custom Superior Antibodies Services for KIRREL2
	Novus Biologicals KIRREL2 Antibodies
	Search for Antibodies for KIRREL2 at Abcam
	Uscn Antibodies for KIRREL2
	Search ThermoFisher Antibodies for KIRREL2

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for KIRREL2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for KIRREL2

Protein Domains /
Families
for KIRREL2 gene

ProtoNet protein and cluster: Q6UWL6

Function
for KIRREL2 gene

miRNA Products:		OriGene 3'-UTR Clone (see all 3): KIRREL2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KIRREL2
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate KIRREL2:
		hsa-miR-203 hsa-miR-4328 hsa-miR-3160-3p
		SwitchGear 3'UTR luciferase reporter plasmid: KIRREL2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KIRREL2 (see all 4) OriGene shRNA RFP: KIRREL2 OriGene siRNA: KIRREL2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIRREL2

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for KIRREL2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIRREL2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIRREL2 (see all 4) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): KIRREL2 (NM_199179)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KIRREL2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIRREL2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for KIRREL2
		Search LifeMap BioReagents cell lines for KIRREL2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIRREL2

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

Pathways & Interactions
for KIRREL2 gene

	Super-pathway	contained gene-specific pathways
1	Nephrin interactions	Nephrin interactions 1.00
2	Cell-cell junction organization	Cell-Cell communication 0.45

2        Reactome Pathways for KIRREL2

	Nephrin interactions
	Cell-Cell communication

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for KIRREL2 gene

Transcripts
for KIRREL2 gene

Expression
for KIRREL2 gene

KIRREL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCACCCAAT

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	BrainFourth Ventricle			Brain
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIRREL2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KIRREL2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIRREL2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIRREL2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIRREL2

Orthologs
for KIRREL2 gene

Paralogs
for KIRREL2 gene

Paralogs for KIRREL2 gene

KIRREL²  KIRREL3²  NPHS1²  

2 SIMAP similar genes for KIRREL2 using alignment to 2 protein entries:     KIRR2_HUMAN (see all proteins):

KIRREL3    KIRREL

KIRREL2 for paralogs           About GeneDecksing

Genomic Variants
for KIRREL2 gene

10/239 NCBI SNPs in KIRREL2 are shown (see all 239)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1151033891,2	F,	--	36345944(+)	ACCCCC/AGCCAA	3	--	us2k1		1		WA	118
rs4431861,2	C,F,A,H,	--	36345951(+)	CCAATA/CTCGTT	3	--	us2k1		23		MN NS EA NA WA CSA	2532
rs1500980261,2		--	36345982(+)	TCTGGC/TCTCAG	3	--	us2k1		0	--	--	--	--
rs4356051,2	C,F,H,	--	36346000(+)	CTTCAT/CCCTCG	3	--	us2k1		22		MN NS EA NA WA	2362
rs784924271,2		--	36346046(+)	CCTTGC/ACCTCC	3	--	us2k1		1		EA	120
rs768145691,2	F,	--	36346060(+)	CACCTC/GCCCTC	3	--	us2k1		1		WA	118
rs1384326501,2		--	36346108(+)	GATGCC/TGAGCT	3	--	us2k1		0	--	--	--	--
rs1865113371,2		--	36346193(+)	TGGGGC/TCTTTA	3	--	us2k1		0	--	--	--	--
rs4381991,2	C,	--	36346229(+)	CCTTGG/ACTGTT	3	--	us2k1		9		EA NA MN WA	482
rs3706441,2	C,	--	36346230(-)	AAACAG/ACCAAG	3	--	us2k1		6		MN NA WA EA	428

HapMap Linkage Disequilibrium report for KIRREL2 (36346763 - 36358048 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for KIRREL2
     1 CNV: 5097

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIRREL2

DNA2.0 Custom Variant and Variant Library Synthesis for KIRREL2

Disorders / Diseases
for KIRREL2 gene

6 diseases for KIRREL2

1 Novoseek disease relationship for KIRREL2 gene    About this table

Publications
for KIRREL2 gene

PubMed articles for KIRREL2 gene, integrated from 9 sources (see all 19): (articles sorted by number of sources associating them with KIRREL2)

Utopia: connect your pdf to the dynamic world of online information

1. Kirrel2, a novel immunoglobulin superfamily gene expressed primarily in beta cells of the pancreatic islets. (PubMed id 12837264)^{1, 2, 3, 9} Sun C.... Carulli J.P. (2003)
2. Filtrin is a novel member of nephrin-like proteins. (PubMed id 12504092)^{1, 3, 9} Ihalmo P....Holthofer H. (2003)
3. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PubMed id 21697133)^{1, 2} Oshikawa M.... Kato S. (2011)
4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
7. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2} Wiemann S.... Poustka A. (2001)
8. Regulation of Neph3 gene in podocytes--key roles of t ranscription factors NF-kappaB and Sp1. (PubMed id 19703278)^{1, 9} Ristola M....HolthAPfer H. (2009)
9. Densin and filtrin in the pancreas and in the kidney, targets for humoral autoimmunity in patients with type 1 diabetes. (PubMed id 16741999)^{1, 9} Rinta-Valkama J....Holthofer H. (2007)
10. Transcription of nephrin-Neph3 gene pair is synergisti cally activated by WT1 and NF-kB and silenced by DNA methylation. (PubMed id 21980157)¹ Ristola M....Lehtonen S. (2012)

External Searches for KIRREL2 gene

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Products
for KIRREL2 gene