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KIRREL2 Gene

protein-coding   GIFtS: 57
GCID: GC19P036347

Kin Of IRRE Like 2 (Drosophila)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kin Of IRRE Like 2 (Drosophila)1 2     NLG12 5
NEPH32 3 5     Kin Of IRRE-Like Protein 22
Kin Of Irregular Chiasm-Like Protein 22 3     Kin Of Irregular Chiasm-Like 22
Nephrin-Like Protein 32 3     Nephrin-Like 32
FILTRIN2 5     Nephrin-Like Gene 12

External Ids:    HGNC: 188161   Entrez Gene: 840632   Ensembl: ENSG000001262597   OMIM: 6077625   UniProtKB: Q6UWL63   

Export aliases for KIRREL2 gene to outside databases

Previous GC identifers: GC00U991236 GC19P041023 GC19P041039 GC19P041038 GC19P032853


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KIRREL2 Gene:
KIRREL2 (kin of IRRE like 2 (Drosophila)) is a protein-coding gene. An important paralog of this gene is KIRREL.

Gene Wiki entry for KIRREL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the KIRREL2 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-1   E2F   p53   c-Myb   E2F-2   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKIRREL2 promoter sequence
   Search Chromatin IP Primers for KIRREL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KIRREL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.12   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.13

KIRREL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIRREL2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P036347:  view genomic region     (about GC identifiers)

Start:
36,346,763 bp from pter      End:
36,358,048 bp from pter
Size:
11,286 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KIRR2_HUMAN, Q6UWL6 (See protein sequence)
Recommended Name: Kin of IRRE-like protein 2 precursor  
Size: 708 amino acids; 75092 Da
Subunit: Interacts with NPHS2/podocin (via the C-terminus). Interacts with NPHS1 (via the Ig-like domains) (By
similarity)
Sequence caution: Sequence=AAH64925.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
Secondary accessions: C9JHF1 C9JJ76 F1T0I2 Q6P1R1 Q7Z5P1 Q7Z5P2 Q96IQ8 Q9H0T1
Alternative splicing: 4 isoforms:  Q6UWL6-1   Q6UWL6-2   Q6UWL6-3   Q6UWL6-5   

Explore the universe of human proteins at neXtProt for KIRREL2: NX_Q6UWL6

Explore proteomics data for KIRREL2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn143, Asn301, Asn484
  • Modification sites at PhosphoSitePlus

  • See KIRREL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_115499.4  NP_954648.2  NP_954649.2  

    ENSEMBL proteins: 
     ENSP00000466460   ENSP00000465305   ENSP00000345067   ENSP00000353331   ENSP00000262625  
    Reactome Protein details: Q6UWL6

    KIRREL2 Human Recombinant Protein Products:

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    Novus Biologicals KIRREL2 Protein
    Novus Biologicals KIRREL2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KIRREL2

     
    Search eBioscience for Proteins for KIRREL2 

     
    antibodies-online proteins for KIRREL2 (4 products) 

     
    antibodies-online peptides for KIRREL2

    KIRREL2 Antibody Products:

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    antibodies-online antibodies for KIRREL2 (39 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    C2SET: Immunoglobulin superfamily / C2-set domain containing
    ISET: Immunoglobulin superfamily / I-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    Selected InterPro protein domains (see all 6):
     IPR003598 Ig_sub2
     IPR007110 Ig-like_dom
     IPR013162 CD80_C2-set
     IPR003599 Ig_sub
     IPR013098 Ig_I-set

    Graphical View of Domain Structure for InterPro Entry Q6UWL6

    ProtoNet protein and cluster: Q6UWL6

    2 Blocks protein domains:
    IPB003599 Immunoglobulin subtype
    IPB013162 CD80-like C2-set immunoglobulin


    UniProtKB/Swiss-Prot: KIRR2_HUMAN, Q6UWL6
    Similarity: Belongs to the immunoglobulin superfamily
    Similarity: Contains 5 Ig-like C2-type (immunoglobulin-like) domains


    Find genes that share domains with KIRREL2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with KIRREL2           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for KIRREL2:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Increased gamma-H2AX phosphory 

         1 MGI phenotypic allele for Kirrel2 (no phenotypes)

    Find genes that share phenotypes with KIRREL2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Kirrel2tm1Lex for KIRREL2

       genOway: Develop your customized and physiologically relevant rodent model for KIRREL2

    miRNA
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    miRTarBase miRNAs that target KIRREL2:
    hsa-mir-124-3p (MIRT023144)

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    3 qRT-PCR Assays for microRNAs that regulate KIRREL2:
    hsa-miR-203 hsa-miR-4328 hsa-miR-3160-3p
    SwitchGear 3'UTR luciferase reporter plasmidKIRREL2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KIRREL2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): KIRREL2 (NM_199179)
    Sino Biological Human cDNA Clone for KIRREL2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KIRREL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIRREL2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIRREL2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KIRR2_HUMAN, Q6UWL6: Cell membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    golgi apparatus1
    lysosome1
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005911cell-cell junction ----
    GO:0016020membrane ----
    GO:0016021integral component of membrane NAS12837264
    GO:0036057slit diaphragm IEA--

    Find genes that share ontologies with KIRREL2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KIRREL2 About    
    See pathways by source

    SuperPathContained pathways About
    1Cell junction organization
    Cell-Cell communication0.64
    2Nephrin interactions
    Nephrin interactions


    Find genes that share SuperPaths with KIRREL2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for KIRREL2
        Nephrin interactions


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KIRREL2
    Interactions:

        Search GeneGlobe Interaction Network for KIRREL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for KIRREL2 (ENSP000003533314) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DLL1ENSP000003557184STRING: ENSP00000355718
    DLL4ENSP000002497494STRING: ENSP00000249749
    TANC1ENSP000002636354STRING: ENSP00000263635
    TANC2ENSP000003875934STRING: ENSP00000387593
    PNMTENSP000002695824STRING: ENSP00000269582
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001933negative regulation of protein phosphorylation IEA--
    GO:0007155cell adhesion NAS12837264
    GO:0016337cell-cell adhesion IEA--

    Find genes that share ontologies with KIRREL2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KIRREL2 (KIRR2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KIRREL2 gene (3 alternative transcripts): 
    NM_032123.5  NM_199179.2  NM_199180.2  

    Unigene Cluster for KIRREL2:

    Kin of IRRE like 2 (Drosophila)
    Hs.145729  [show with all ESTs]
    Unigene Representative Sequence: NM_199180
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000586102 ENST00000592409 ENST00000347900(uc002oca.4) ENST00000360202(uc002ocb.4 uc002ocd.4)
    ENST00000262625(uc002obz.4)
    miRNA
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    Block miRNA regulation of human, mouse, rat KIRREL2 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate KIRREL2:
    hsa-miR-203 hsa-miR-4328 hsa-miR-3160-3p
    SwitchGear 3'UTR luciferase reporter plasmidKIRREL2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for KIRREL2
    Predesigned siRNA for gene silencing in human, mouse, rat KIRREL2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KIRREL2
      QuantiTect SYBR Green Assays in human, mouse, rat KIRREL2
      QuantiFast Probe-based Assays in human, mouse, rat KIRREL2

    Additional mRNA sequence: 

    AB593116.1 AK307865.1 AL136654.1 AY305301.1 AY305302.1 AY358742.1 BC007312.1 BC064925.1 

    6 DOTS entries:

    DT.99975652  DT.97762788  DT.101983411  DT.99934218  DT.75101711  DT.102821634 

    Selected AceView cDNA sequences (see all 43):

    AI625788 NM_199180 AL529115 AA491348 NM_032123 BM693057 BU069437 NM_199179 
    BC007312 BU740973 BU180679 BQ272524 BE504729 BC064925 CR593108 AW025274 
    AL136654 BX327114 AY305302 BE255083 AI912748 BQ055677 AI983277 AW235753 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for KIRREL2    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b
    SP1:                                                                                                                                    
    SP2:                                                                                                                                    
    SP3:                                                                                                                                    
    SP4:                          -                                                                                                         


    ECgene alternative splicing isoforms for KIRREL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KIRREL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCACCCAAT
    KIRREL2 Expression
    About this image


    KIRREL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)
             Fourth Ventricle
    KIRREL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KIRREL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.145729

    UniProtKB/Swiss-Prot: KIRR2_HUMAN, Q6UWL6
    Tissue specificity: Highly expressed in beta-cells of the pancreatic islets

        Custom PCR Arrays for KIRREL2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIRREL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KIRREL2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kirrel21 , 5 kin of IRRE like 2 (Drosophila)1, 5 84(n)1
    84.86(a)1
      7 (18.36 cM)5
    2439111  NM_172898.31  NP_766486.11 
     304475345 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    39(a)
    many ↔ many
    GL343276.1(1229145-1264738)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC057728.12   -- 71.55(n)    BC057728.1 
    zebrafish
    (Danio rerio)
    Actinopterygii kirrel3l6
    kin of IRRE like 3 like
    37(a)
    many ↔ many
    Zv9_scaffold3455(348776-423355) ENSDARG00000019473
    fruit fly
    (Drosophila melanogaster)
    Insecta rst6
    kirre6
    kin of irre
    20(a)
    18(a)
    many ↔ many
    many ↔ many
    X(2846241-2867867)
    X(2634417-3028565)
    worm
    (Caenorhabditis elegans)
    Secernentea syg-16
    Protein SYG-1, isoform b (syg-1) mRNA, complete cd...
    22(a)
    1 → many
    X(2509608-2515317) WBGene00006365


    ENSEMBL Gene Tree for KIRREL2 (if available)
    TreeFam Gene Tree for KIRREL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KIRREL2 gene
    KIRREL2  KIRREL32  NPHS12  
    2 SIMAP similar genes for KIRREL2 using alignment to 3 protein entries:     KIRR2_HUMAN (see all proteins):
    KIRREL3    KIRREL

    Find genes that share paralogs with KIRREL2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KIRREL2 (see all 355)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1151033891,2
    F--36345944(+) ACCCCC/AGCCAA 3 -- us2k11Minor allele frequency- A:0.06WA 118
    rs4431861,2
    C,F,A,H--36345951(+) CCAATA/CTCGTT 3 -- us2k123Minor allele frequency- C:0.22MN NS EA NA WA CSA 2532
    rs1500980261,2
    --36345982(+) TCTGGC/TCTCAG 3 -- us2k10--------
    rs4356051,2
    C,F,H--36346000(+) CTTCAT/CCCTCG 3 -- us2k122Minor allele frequency- C:0.10MN NS EA NA WA 2362
    rs784924271,2
    F--36346046(+) CCTTGC/ACCTCC 3 -- us2k11Minor allele frequency- A:0.01EA 120
    rs768145691,2
    F--36346060(+) CACCTC/GCCCTC 3 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1384326501,2
    --36346108(+) GATGCC/TGAGCT 3 -- us2k10--------
    rs1865113371,2
    --36346193(+) TGGGGC/TCTTTA 3 -- us2k10--------
    rs4381991,2
    C--36346229(+) CCTTGG/ACTGTT 3 -- us2k19Minor allele frequency- A:0.08EA NA MN WA 482
    rs3706441,2
    C,F--36346230(-) AAACAG/ACCAAG 3 -- us2k16Minor allele frequency- A:0.09MN NA WA EA 428

    HapMap Linkage Disequilibrium report for KIRREL2 (36346763 - 36358048 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for KIRREL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911640CNV Loss21882294
    nsv911639CNV Loss21882294
    dgv51n68CNV Loss17160897
    nsv911638CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607762    OMIM disorders: --


    Find genes that share disorders with KIRREL2           About GenesLikeMe

    1 Novoseek inferred disease relationship for KIRREL2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    proteinuria 41.4 1 17442742 (1)

    Genetic Association Database (GAD): KIRREL2
    Human Genome Epidemiology (HuGE) Navigator: KIRREL2 (4 documents)

    Export disorders for KIRREL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KIRREL2 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with KIRREL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Kirrel2, a novel immunoglobulin superfamily gene expressed primarily in beta cells of the pancreatic islets. (PubMed id 12837264)1, 2, 3, 9 Sun C.... Carulli J.P. (Genomics 2003)
    2. Filtrin is a novel member of nephrin-like proteins. (PubMed id 12504092)1, 3, 9 Ihalmo P....HolthAPfer H. (Biochem. Biophys. Res. Commun. 2003)
    3. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PubMed id 21697133)1, 2 Oshikawa M.... Kato S. (Invest. Ophthalmol. Vis. Sci. 2011)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    8. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    9. Regulation of Neph3 gene in podocytes--key roles of transcription factors NF-kappaB and Sp1. (PubMed id 19703278)1, 9 Ristola M....HolthAPfer H. (BMC Mol. Biol. 2009)
    10. Densin and filtrin in the pancreas and in the kidney, targets for humoral autoimmunity in patients with type 1 diabetes. (PubMed id 16741999)1, 9 Rinta-Valkama J....HolthAPfer H. (Diabetes Metab. Res. Rev. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84063 HGNC: 18816 AceView: KIRREL2 Ensembl:ENSG00000126259 euGenes: HUgn84063
    ECgene: KIRREL2 H-InvDB: KIRREL2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KIRREL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KIRREL2 gene:
    Search GeneIP for patents involving KIRREL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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