KIR3DX1 Gene
protein-coding GIFtS: 37
GCID: GC19P055044
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killer cell immunoglobulin-like receptor, three domains,...(Previous name: leukocyte receptor cluster (LRC) member 12 )
(Previous symbol: LENG12)
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Aliases
for KIR3DX1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
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| Killer Cell Immunoglobulin-Like Receptor, Three Domains, X11 2 | | LENG121 2 3 | | KIR3DL02 3 | | FLJ000601 | | Leukocyte Receptor Cluster (LRC) Member 121 | | Leukocyte Receptor Cluster Member 123 |
| External Ids: | HGNC: 250431 | Entrez Gene: 900112 | Ensembl: ENSG000001049707 | UniProtKB: Q9H7L23 | | ORGUL members: | |
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| NONCODE:n407250 | |
Export aliases for KIR3DX1 gene to outside databasesPrevious GC identifers: GC19P059740 GC19P051367
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Summaries
for KIR3DX1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for KIR3DX1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KIR3DX1 gene promoter:
GR RORalpha1 NRSF form 1 ARP-1 GR-alpha NRSF form 2
Other transcription factors
Search SABiosciences Chromatin IP Primers for KIR3DX1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIR3DX1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.42 Ensembl cytogenetic band: 19q13.42 HGNC cytogenetic band: 19q13.42KIR3DX1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P055044: view genomic region
(about GC identifiers)
Start:
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55,043,909 bp from pter |
End:
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55,057,053 bp from pter |
Size:
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13,145 bases |
Orientation:
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plus strand |
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Proteins
for KIR3DX1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: KI3X1_HUMAN, Q9H7L2 (See
protein sequence)Recommended Name: Putative killer cell immunoglobulin-like receptor-like protein KIR3DX1 precursor Size: 352 amino acids; 38777 Da
Subcellular location: Secreted (Potential)
Caution: Could be the product of a pseudogene. According to PubMed:16911775, it could constitute the ancestral killerimmunoglobulin-like receptor gene in primates
Sequence caution: Sequence=BAB15757.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites andprobable target of nonsense-mediated mRNA decay;
Secondary accessions: B7WNL0 Q8N0S4Explore the universe of human proteins at neXtProt for KIR3DX1: NX_Q9H7L2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H7L2
KIR3DX1 Protein expression data from MOPED and PaxDb: About this image 
ENSEMBL proteins: ENSP00000396692 ENSP00000395115 ENSP00000401224 ENSP00000335388 ENSP00000221567
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005576 | extracellular region |
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KIR3DX1 for ontologies About GeneDecksing
KIR3DX1 Antibody Products:
Assay Products for KIR3DX1: |
Protein
Domains /
Families
for KIR3DX1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KIR3DX1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H7L2ProtoNet protein and cluster: Q9H7L2 UniProtKB/Swiss-Prot: KI3X1_HUMAN, Q9H7L2Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains |
Function
for KIR3DX1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIR3DX1 |
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Pathways & Interactions
for KIR3DX1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIR3DX1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for KIR3DX1 (ENSP000003353884) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for KIR3DX1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
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 Browse Tocris compounds for KIR3DX1
Search CenterWatch for drugs/clinical trials and news about KIR3DX1 / KI3X1 
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Transcripts
for KIR3DX1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for KIR3DX1 gene (2 alternative transcripts): NM_001047605.1 NM_033206.1 Unigene Cluster for KIR3DX1: Killer cell immunoglobulin-like receptor, three domains, X1 Hs.288520 [show with all ESTs]Unigene Representative Sequence: BC0331958 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000446586(uc010yfc.1) ENST00000447145(uc010yfd.1) ENST00000434659(uc010yfb.1)
ENST00000465702 ENST00000471931 ENST00000335056(uc010yfa.1 uc010erm.2)
ENST00000221567 ENST00000482404
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIR3DX1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat KIR3DX1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIR3DX1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIR3DX1 |
Additional cDNA sequence: BC033195.1 BC171827.1 BC171832.1 BC171834.1 BC171838.1 BC171839.1 DQ224421.1 NR_026716.1 2 DOTS entries: DT.95133086 DT.95198652 5 AceView cDNA sequences: BC033195 BG743947 NM_033206 AK024467 BG744627
GeneLoc Exon Structure
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Expression
for KIR3DX1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KIR3DX1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See KIR3DX1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KIR3DX1
SOURCE GeneReport for Unigene cluster: Hs.288520
UniProtKB/Swiss-Prot: KI3X1_HUMAN, Q9H7L2Tissue specificity: Expressed in NK-cells
SABiosciences Custom PCR Arrays for KIR3DX1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIR3DX1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat KIR3DX1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIR3DX1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIR3DX1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIR3DX1 |
Orthologs
for KIR3DX1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for KIR3DX1 gene from 2/6 species (see all 6) About this table
ENSEMBL Gene Tree for KIR3DX1 (if available)
TreeFam Gene Tree for KIR3DX1 (if available) |
Paralogs
for KIR3DX1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KIR3DX1 gene
- KIR2DL42 LILRB42 LILRB12 LILRA62 IGSF12 LILRA52 KIR3DL12 OSCAR2
- NCR12 LILRA42 ENSG000002177922 TARM12 LILRA32 LILRB52 LILRA12 KIR3DL32
- KIR2DL12 LILRB22 A1BG2 KIR2DL22 LILRA22 KIR3DL22 KIR2DL32 FCAR2
- LILRB32 GP62
18/48 SIMAP similar genes for KIR3DX1 using alignment to 3 protein entries: KI3X1_HUMAN (see all proteins)
(see all similar genes):p58 KIR-G2 KIR-K39 KIR-K65 KIR-K61 KIR-K78
KIR-K3 KIR-K36 KIR-K15 KIR-K64 KIR-K9 KIR3DL1/2V
KIR3DS1 1060P11.3 KIR-123FM KIR222 KIR3DL1 KIR2DL4
KIR3DX1 for paralogs About GeneDecksing
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Genomic Variants
for KIR3DX1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KIR3DX1 (55043909 - 55057053 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for KIR3DX1
3 CNVs: 4088 30082 53601 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for KIR3DX1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KIR3DX1 for disorders About GeneDecksing
2  diseases for KIR3DX1: About MalaCardshepatitis b hepatitis
Human Genome Epidemiology (HuGE) Navigator: KIR3DX1 (1 document)
Export disorders for KIR3DX1 gene to outside databases
|
Publications
for KIR3DX1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KIR3DX1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KIR3DX1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of the ancestral killer immunoglobulin-like receptor gene in primates. (PubMed id 16911775)1, 2 Sambrook J.G....Beck S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Human chromosome 19 and related regions in mouse: con servative and lineage-specific evolution. (PubMed id 11441184)1, 3 Dehal P....Stubbs L. (2001)
- New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
- Expanding the substantial interactome of NEMO using p rotein microarrays. (PubMed id 20098747)1 Fenner B.J....Prehn J.H. (2010)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for KIR3DX1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing KIR3DX1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing KIR3DX1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KIR3DX1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KIR3DX1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for KIR3DX1 gene:
Search GeneIP for patents involving KIR3DX1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KIR3DX1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KIR3DX1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIR3DX1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIR3DX1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIR3DX1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIR3DX1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIR3DX1 |
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 |  |  |  | |
| | | | Search Tocris compounds for KIR3DX1 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIR3DX1 |
|  |  |  | | | | Search ThermoFisher Antibodies for KIR3DX1 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat KIR3DX1 |
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Last full update: 18 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013
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