KIR3DS1 Gene
protein-coding GIFtS: 47
GCID: GC19P9I0018
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killer cell immunoglobulin-like receptor, three domains,...
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Aliases for KIR3DS1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Killer Cell Immunoglobulin-Like Receptor, Three Domains, Short CytoplasmicTail, 11 2 | | KIR-G12 | | Natural Killer-Associated Transcript 102 3 | | Killer Cell Immunoglobulin-Like Receptor 3DS12 | | NKAT-102 3 | | Killer Cell Immunoglobulin-Like Receptor KIR3DS12 | | NKAT102 3 | | Killer Ig Receptor2 | | MHC Class I NK Cell Receptor2 3 | | AMB115 | | Nkat101 | | KIR3DL15 | | CD158E22 | | NKAT35 | | KIR-123FM2 | | NKB15 |
Export aliases for KIR3DS1 gene to outside databasesPrevious GC identifers: GC19U990059 GC19P060011 GC00P000070 GC19P000070 GC00U921579 GC19P060021 GC19P9I0071 GC19P9I0072 GC19P9I0073 GC19P9I0074 GC19P9I0010 GC19P9I0012 GC19P9I0014 GC19P9I0016 |
Summaries for KIR3DS1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for KIR3DS1: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells andsubsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies amonghaplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). TheKIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they havea long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signalsupon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the shortcytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein totransduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIRproteins are thought to play an important role in regulation of the immune response. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: KI3S1_HUMAN, Q14943Function: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells
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Genomic Views for KIR3DS1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:NT_113949.1 Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for KIR3DS1 Other transcription factors
Search SABiosciences Chromatin IP Primers for KIR3DS1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIR3DS1 |
Genomic Location: Chromosome:19
Entrez Gene cytogenetic band: 19q13.4 Ensembl cytogenetic band: 19_GL000209.1 HGNC cytogenetic band: 19q13.4 GRCh37 novel patchGeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P9I0018: view genomic region
(about GC identifiers)
Start:
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70,097 bp from start of contig NT_113949 |
End:
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84,658 bp from start of contig NT_113949 |
Size:
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14,562 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr19+,GL000209.1 7,891-96,246 |
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Proteins for KIR3DS1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: KI3S1_HUMAN, Q14943 (See
protein sequence)Recommended Name: Killer cell immunoglobulin-like receptor 3DS1 precursor Size: 387 amino acids; 42902 Da
Subcellular location: Cell membrane; Single-pass type I membrane proteinExplore the universe of human proteins at neXtProt for KIR3DS1: NX_Q14943
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q14943 KIR3DS1 Protein expression data from MOPED and PaxDb: About this image 
 REFSEQ proteins: NP_001077008.1 ENSEMBL proteins: ENSP00000375611 ENSP00000383672 ENSP00000383645 ENSP00000383649 ENSP00000343498 ENSP00000383652 ENSP00000383651 ENSP00000383650 ENSP00000383646 ENSP00000383644 Reactome Protein details: Q14943 Human Recombinant Protein Products for KIR3DS1:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
KIR3DS1 for ontologies About GeneDecksing
KIR3DS1 Antibody Products: Assay Products for KIR3DS1: |
Protein
Domains / Families for KIR3DS1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KIR3DS1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q14943ProtoNet protein and cluster: Q14943 1 Blocks protein family: IPB003599 Immunoglobulin subtype
UniProtKB/Swiss-Prot: KI3S1_HUMAN, Q14943Similarity: Belongs to the immunoglobulin superfamilySimilarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains |
Function for KIR3DS1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Molecular Function: UniProtKB/Swiss-Prot Summary: KI3S1_HUMAN, Q14943Function: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells Genatlas biochemistry entry for KIR3DS1:natural killer cell immunoglobulin-like activating receptor for HLA-B antigens,3DS1,70kDa,with alternatively splicedforms
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
KIR3DS1 for ontologies About GeneDecksing
Animal Models:
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIR3DS1 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIR3DS1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for KIR3DS1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIR3DS1  |
|
Pathways & Interactions for KIR3DS1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Immune System | | | 2 | Signaling by FGFR | |
Pathway sources See GeneCards unified pathways Show all pathways
3
Reactome Pathways for KIR3DS1
KIR3DS1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KIR3DS1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
 5/10 Interacting proteins for KIR3DS1 (ENSP000003836454) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
KIR3DS1 for ontologies About GeneDecksing
|
Drugs & Compounds for KIR3DS1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for KIR3DS1 Search CenterWatch for drugs/clinical trials and news about KIR3DS1 / KI3S1 
|
Transcripts for KIR3DS1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for KIR3DS1 gene: NM_001083539.1 Unigene Cluster for KIR3DS1: Killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1 Hs.743496 [show with all ESTs]Unigene Representative Sequence: NM_00108353910 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000391731 ENST00000400875(uc010euy.2) ENST00000400847 ENST00000400851(uc002qtv.3 uc010evf.3) ENST00000344867(uc002qtt.2 uc002qts.2) ENST00000400854(uc010evd.3 uc002quc.4) ENST00000400853(uc002qud.4) ENST00000400852(uc002quh.4 uc002que.4 uc002quf.4 uc010eve.3 uc002qug.4) ENST00000400848(uc010yic.2 uc021vdb.1 uc010yie.2 uc010evg.1 uc010evh.1 uc002qui.2) ENST00000400846(uc002quk.1)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIR3DS1 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIR3DS1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: KIR3DS1 (NM_001083539) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KIR3DS1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIR3DS1  |
Additional cDNA sequence: AF022044.1 AJ417558.3 AK301140.1 BC098107.1 BC098288.1 BC105679.1 BC143616.1 BC143618.1 EF370406.1 EF582383.1 L76661.1 U73396.1 X97232.1 X97233.1 4 DOTS entries: DT.91758240 DT.455734 DT.121450388 DT.95344541 GeneLoc Exon Structure
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Expression for KIR3DS1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KIR3DS1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: --
 About this image See KIR3DS1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for KIR3DS1
SOURCE GeneReport for Unigene cluster: Hs.743496
UniProtKB/Swiss-Prot: KI3S1_HUMAN, Q14943Tissue specificity: Expressed in NK and T-cell lines but not in B-lymphoblastoid cell lines or in a colon carcinomacell line SABiosciences Custom PCR Arrays for KIR3DS1
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIR3DS1 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat KIR3DS1 | |  | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIR3DS1 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIR3DS1 |
Orthologs for KIR3DS1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for KIR3DS1 gene from 2/6 species (see all 6) About this table
ENSEMBL Gene Tree for KIR3DS1 (if available) TreeFam Gene Tree for KIR3DS1 (if available)  |
Paralogs for KIR3DS1 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for KIR3DS1 gene
- KIR2DL42 LILRB42 LILRB12 LILRA62 IGSF12 LILRA52 KIR3DL12 OSCAR2
- NCR12 LILRA42 ENSG000002177922 TARM12 KIR3DX12 LILRA32 LILRB52 LILRA12
- KIR3DL32 KIR2DL12 LILRB22 A1BG2 LILRA22 KIR3DL22 KIR2DL32 FCAR2
- LILRB32 GP62
18/54 SIMAP similar genes for KIR3DS1 using alignment to 12 protein entries: KI3S1_HUMAN (see all proteins)
(see all similar genes):KIR-G1 KIR-123FM KIR3DL1 KIR3DL1/2V KIR411 KIR-K39 KIR3DL2 KIR221 KIR-K36 kir3d KIR2DS2 KIR-K15 KIR-G2 KIR2DS1 KIR-K64 KIR2DS4 KIR2DL3 KIR-K65
KIR3DS1 for paralogs About GeneDecksing
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Genomic Variants for KIR3DS1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| UniProtKB/Swiss-Prot: KI3S1_HUMAN, Q14943Polymorphism: The KIR genes are located in a segment of DNA on 19q13.4 in the leukocyte receptor complex that hasundergone expansion and contraction over time, probably through unequal crossing-over. Thus, KIR haplotypes vary inthe number and types of genes, although a few framework loci, such as the gene KIR3DL1, are present on all or nearlyall haplotypes. KIR3DL1 and KIR3DS1 segregate as alleles of the locus KIR3DL1/3DS1 Human Gene Mutation Database (HGMD): KIR3DS1
Locus Specific Mutation Databases (LSDB): KIR3DS1
 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases for KIR3DS1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KIR3DS1 for disorders About GeneDecksing
OMIM gene information: 604946 OMIM disorders: 609423 20/45 diseases for KIR3DS1 (see all 45): About MalaCardsaids, delayed/rapid progression to vogt-koyanagi-harada disease birdshot chorioretinopathy tropical spastic paraparesis microscopic polyangiitis spastic paraparesis familial mediterranean fever systemic lupus erythematosus non-hodgkin lymphoma type 1 diabetes mellitus anterior uveitis systemic lupus erythematosus, association with spontaneous abortion lupus erythematosus ankylosing spondylitis hodgkin's lymphoma diabetes mellitus spasticity uveitis spondylitis
Genetic Association Database (GAD): KIR3DS1 Human Genome Epidemiology (HuGE) Navigator: KIR3DS1 (115 documents) Export disorders for KIR3DS1 gene to outside databases
|
Publications for KIR3DS1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KIR3DS1 gene, integrated from 9 sources (see all 119): (articles sorted by number of sources associating them with KIR3DS1) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Alternatively spliced forms of human killer inhibitory receptors. (PubMed id 8662091)1, 2, 3 Dohring C....Colonna M. (1996)
- Distribution of killer cell immunoglobulin-like receptor genes in the Chinese Han population. (PubMed id 15896204)1, 4 Jiang K....Yan L.X. (2005)
- Human diversity in killer cell inhibitory receptor genes. (PubMed id 9430221)1, 2 Uhrberg M.... Parham P. (1997)
- Killer-cell immunoglobulin-like receptors (KIR) in sev ere A (H1N1) 2009 influenza infections. (PubMed id 22652695)1 Aranda-Romo S....Noyola D.E. (2012)
- Association of killer cell immunoglobulin-like recepto rs with pulmonary tuberculosis in Chinese Han. (PubMed id 22653583)1 Lu C....Lu Z.M. (2012)
- Killer cell immunoglobulin-like receptor genes in Spa nish multiple sclerosis patients. (PubMed id 21665278)1 GarcA-a-LeA^n J.A....Leyva-FernA!ndez L. (2011)
- Autoimmune rheumatic diseases and their association w ith killer immunoglobulin-like receptor genes. (PubMed id 21779711)1 Salim P.H....Xavier R.M. (2011)
- Analysis of binding of KIR3DS1*014 to HLA suggests di stinct evolutionary history of KIR3DS1. (PubMed id 21804024)1 O'Connor G.M....McVicar D.W. (2011)
- Systemic lupus erythematosus: association with KIR an d SLC11A1 polymorphisms, ethnic predisposition and influence in clinical manife stations at onset revealed by ancestry genetic markers in an urban Brazilian po pulation. (PubMed id 21233146)1 Pedroza L.S....Santos E.J. (2011)
- The beneficial impact of missing KIR ligands and abse nce of donor KIR2DS3 gene on outcome following unrelated hematopoietic SCT for myeloid leukemia in the Chinese population. (PubMed id 20173784)1 Wu G.Q....Huang H. (2010)
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External Searches for KIR3DS1 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing KIR3DS1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KIR3DS1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KIR3DS1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for KIR3DS1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KIR3DS1 gene: Search GeneIP for patents involving KIR3DS1
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for KIR3DS1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory) About This Section
|
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 | | KIR3DS1 Proteins, Antibodies, CLIAs, and ELISAs |
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| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIR3DS1 |
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