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Aliases for KIR3DS1 Gene

Aliases for KIR3DS1 Gene

  • Killer Cell Immunoglobulin-Like Receptor, Three Domains, Short Cytoplasmic Tail, 1 2 3
  • Natural Killer-Associated Transcript 10 3 4
  • MHC Class I NK Cell Receptor 3 4
  • NKAT-10 3 4
  • NKAT10 3 4
  • Killer Cell Immunoglobulin-Like Receptor KIR3DS1 3
  • Killer Ig Receptor 3
  • KIR-123FM 3
  • CD158E2 3
  • KIR-G1 3

External Ids for KIR3DS1 Gene

Previous GeneCards Identifiers for KIR3DS1 Gene

  • GC19U990059
  • GC19P060011
  • GC00P000070
  • GC19P000070
  • GC00U921579
  • GC19P060021
  • GC19P9I0071
  • GC19P9I0072
  • GC19P9I0073
  • GC19P9I0074
  • GC19P9I0010
  • GC19P9I0012
  • GC19P9I0014
  • GC19P9I0016
  • GC19P9I0018
  • GC19P9I0020
  • GC19P9I0030

Summaries for KIR3DS1 Gene

Entrez Gene Summary for KIR3DS1 Gene

  • Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

GeneCards Summary for KIR3DS1 Gene

KIR3DS1 (Killer Cell Immunoglobulin-Like Receptor, Three Domains, Short Cytoplasmic Tail, 1) is a Protein Coding gene. Diseases associated with KIR3DS1 include birdshot chorioretinopathy and hiv-1. Among its related pathways are Immune System and Interleukin receptor SHC signaling. GO annotations related to this gene include MHC class I receptor activity.

UniProtKB/Swiss-Prot for KIR3DS1 Gene

  • Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIR3DS1 Gene

Genomics for KIR3DS1 Gene

Genomic Location for KIR3DS1 Gene

Chromosome:
19
Start:
58,227 bp from pter
End:
72,913 bp from pter
Size:
14,687 bases
Orientation:
Minus strand

Genomic View for KIR3DS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for KIR3DS1 Gene

No data available for Regulatory Elements for KIR3DS1 Gene

Proteins for KIR3DS1 Gene

  • Protein details for KIR3DS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14943-KI3S1_HUMAN
    Recommended name:
    Killer cell immunoglobulin-like receptor 3DS1
    Protein Accession:
    Q14943

    Protein attributes for KIR3DS1 Gene

    Size:
    387 amino acids
    Molecular mass:
    42902 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KIR3DS1 Gene

Proteomics data for KIR3DS1 Gene at MOPED

Post-translational modifications for KIR3DS1 Gene

  • Glycosylation at Asn 92, Asn 179, and Asn 273
  • Modification sites at PhosphoSitePlus

Other Protein References for KIR3DS1 Gene

No data available for DME Specific Peptides for KIR3DS1 Gene

Domains & Families for KIR3DS1 Gene

Protein Domains for KIR3DS1 Gene

Graphical View of Domain Structure for InterPro Entry

Q14943

UniProtKB/Swiss-Prot:

KI3S1_HUMAN :
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily.
Domain:
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Family:
  • Belongs to the immunoglobulin superfamily.
genes like me logo Genes that share domains with KIR3DS1: view

Function for KIR3DS1 Gene

Molecular function for KIR3DS1 Gene

GENATLAS Biochemistry:
natural killer cell immunoglobulin-like activating receptor for HLA-B antigens,3DS1,70kDa,with alternatively spliced forms
UniProtKB/Swiss-Prot Function:
Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells

Gene Ontology (GO) - Molecular Function for KIR3DS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032393 MHC class I receptor activity NAS 8662091
genes like me logo Genes that share ontologies with KIR3DS1: view

Phenotypes for KIR3DS1 Gene

GenomeRNAi human phenotypes for KIR3DS1:
genes like me logo Genes that share phenotypes with KIR3DS1: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIR3DS1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KIR3DS1 Gene

Localization for KIR3DS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIR3DS1 Gene

Cell membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for KIR3DS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 8662091
genes like me logo Genes that share ontologies with KIR3DS1: view

No data available for Subcellular locations from COMPARTMENTS for KIR3DS1 Gene

Pathways & Interactions for KIR3DS1 Gene

genes like me logo Genes that share pathways with KIR3DS1: view

Pathways by source for KIR3DS1 Gene

3 Reactome pathways for KIR3DS1 Gene

Interacting Proteins for KIR3DS1 Gene

Gene Ontology (GO) - Biological Process for KIR3DS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response NAS 8662091
GO:0007165 signal transduction NAS 8662091
GO:0030101 natural killer cell activation NAS 8662091
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with KIR3DS1: view

No data available for SIGNOR curated interactions for KIR3DS1 Gene

Drugs & Compounds for KIR3DS1 Gene

No Compound Related Data Available

Transcripts for KIR3DS1 Gene

mRNA/cDNA for KIR3DS1 Gene

Unigene Clusters for KIR3DS1 Gene

Killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIR3DS1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIR3DS1 Gene

No ASD Table

Relevant External Links for KIR3DS1 Gene

GeneLoc Exon Structure for
KIR3DS1
ECgene alternative splicing isoforms for
KIR3DS1

Expression for KIR3DS1 Gene

mRNA expression in normal human tissues for KIR3DS1 Gene

SOURCE GeneReport for Unigene cluster for KIR3DS1 Gene Hs.743496

mRNA Expression by UniProt/SwissProt for KIR3DS1 Gene

Q14943-KI3S1_HUMAN
Tissue specificity: Expressed in NK and T-cell lines but not in B-lymphoblastoid cell lines or in a colon carcinoma cell line
genes like me logo Genes that share expression patterns with KIR3DS1: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for KIR3DS1 Gene

Orthologs for KIR3DS1 Gene

No data available for Orthologs and Evolution for KIR3DS1 Gene

Paralogs for KIR3DS1 Gene

genes like me logo Genes that share paralogs with KIR3DS1: view

No data available for Paralogs for KIR3DS1 Gene

Variants for KIR3DS1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for KIR3DS1 Gene

Q14943-KI3S1_HUMAN
The KIR genes are located in a segment of DNA on 19q13.4 in the leukocyte receptor complex that has undergone expansion and contraction over time, probably through unequal crossing-over. Thus, KIR haplotypes vary in the number and types of genes, although a few framework loci, such as the gene KIR3DL1, are present on all or nearly all haplotypes. KIR3DL1 and KIR3DS1 segregate as alleles of the locus KIR3DL1/3DS1

Sequence variations from dbSNP and Humsavar for KIR3DS1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
VAR_010377 -
VAR_056093 -
VAR_056094 -
VAR_056095 -
VAR_056096 -

Relevant External Links for KIR3DS1 Gene

HapMap Linkage Disequilibrium report
KIR3DS1
Human Gene Mutation Database (HGMD)
KIR3DS1

No data available for Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for KIR3DS1 Gene

Disorders for KIR3DS1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for KIR3DS1 Gene - From: OMIM and GeneCards

Disorder Aliases PubMed IDs
birdshot chorioretinopathy
  • bscr
hiv-1
  • aids, slow progression to
- elite association

Relevant External Links for KIR3DS1

Genetic Association Database (GAD)
KIR3DS1
Human Genome Epidemiology (HuGE) Navigator
KIR3DS1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIR3DS1
genes like me logo Genes that share disorders with KIR3DS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIR3DS1 Gene

Publications for KIR3DS1 Gene

  1. Alternatively spliced forms of human killer inhibitory receptors. (PMID: 8662091) Doehring C. … Colonna M. (Immunogenetics 1996) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Protective genotypes in HIV infection reflect superior function of KIR3DS1+ over KIR3DL1+ CD8+ T cells. (PMID: 25112829) Zipperlen K. … Grant M. (Immunol. Cell Biol. 2015) 67
  4. Activating killer immunoglobulin-like receptors genes are associated with increased susceptibility to ankylosing spondylitis. (PMID: 25491925) DA-az-PeA+a R. … LA^pez-Larrea C. (Clin. Exp. Immunol. 2015) 67
  5. Killer immunoglobulin-like receptor gene repertoire influences viral load of primary human cytomegalovirus infection in renal transplant patients. (PMID: 25253288) Jones D.C. … Young N.T. (Genes Immun. 2014) 67

Products for KIR3DS1 Gene

Sources for KIR3DS1 Gene

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