KIR3DP1 Gene
pseudogene GIFtS: 29
GCID: GC19P055297
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killer cell immunoglobulin-like receptor, three domains,...
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Aliases
for KIR3DP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
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| Aliases |
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| Killer Cell Immunoglobulin-Like Receptor, Three Domains, Pseudogene 11 2 | | CD158C1 3 5 | | KIR2DS61 2 3 5 | | KIR3DS2P1 2 | | KIR481 2 3 5 | | CD158c2 | | KIRX1 2 3 5 | | CD158c Antigen3 |
Export aliases for KIR3DP1 gene to outside databasesPrevious GC identifers: GC19P059992 GC19U900570 GC19P059976 GC19P059977 GC19P059978 GC19P059979 GC19P059993 GC19P059982 GC19P059994 GC19P051620 |
Summaries
for KIR3DP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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Entrez Gene summary for KIR3DP1:
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells andsubsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies amonghaplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). TheKIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they havea long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signalsupon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the shortcytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein totransduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIRproteins are thought to play an important role in regulation of the immune response. This gene is one of the'framework' loci that is present on all haplotypes. This gene is considered to be a pseudogene based on the absence oftranscription and it lacks several functional domains compared to other killer cell immunoglobulin-like receptors. Arare haplotype, the result of a recombinantion event, has two copies of this gene, one of which may encode a secretedprotein. (PMID: 15580659)(provided by RefSeq, Mar 2011)
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Genomic Views
for KIR3DP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for KIR3DP1
Other transcription factors
Search SABiosciences Chromatin IP Primers for KIR3DP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIR3DP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.42 Ensembl cytogenetic band: 19q13.42 HGNC cytogenetic band: 19q13.4KIR3DP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P055297: view genomic region
(about GC identifiers)
Start:
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55,297,807 bp from pter |
End:
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55,301,870 bp from pter |
Size:
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4,064 bases |
Orientation:
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plus strand |
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Proteins
for KIR3DP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: KI3P1_HUMAN, A8MWS1 (See
protein sequence)Recommended Name: Putative killer cell immunoglobulin-like receptor like protein KIR3DP1 precursor Size: 328 amino acids; 36055 Da
Subcellular location: Secreted (Potential)
Miscellaneous: PubMed:15580659, identified a chromosomal rearrangement producing a recombinant gene composed of thepromoter and first exon of KIR2DL5A fused to KIR3DP1 which was originally thought to be a pseudogene. This leads tothe expression in 4.5 percent of a Spanish Caucasoid population of an mRNA which may encode a chimeric proteinKIR2DL5A/KIR3DP1Explore the universe of human proteins at neXtProt for KIR3DP1: NX_A8MWS1
KIR3DP1 Protein expression data from MOPED and PaxDb: --
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005576 | extracellular region |
IEA | -- |
KIR3DP1 for ontologies About GeneDecksing
KIR3DP1 Antibody Products:
Assay Products for KIR3DP1: |
Protein
Domains /
Families
for KIR3DP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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KIR3DP1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A8MWS1ProtoNet protein and cluster: A8MWS1 UniProtKB/Swiss-Prot: KI3P1_HUMAN, A8MWS1Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains |
Function
for KIR3DP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Pathways & Interactions
for KIR3DP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KIR3DP1
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Drugs & Compounds
for KIR3DP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
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 Browse Tocris compounds for KIR3DP1
Search CenterWatch for drugs/clinical trials and news about KIR3DP1 
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Transcripts
for KIR3DP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for KIR3DP1 gene: NM_001015070.1 1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000580853
GeneLoc Exon Structure
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Expression
for KIR3DP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KIR3DP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCCTGAGGC
About this imageUniProtKB/Swiss-Prot: KI3P1_HUMAN, A8MWS1Tissue specificity: Expressed in peripheral blood cells
SABiosciences Custom PCR Arrays for KIR3DP1
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat KIR3DP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIR3DP1 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIR3DP1 |
Orthologs
for KIR3DP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for KIR3DP1 (if available)
TreeFam Gene Tree for KIR3DP1 (if available) |
Paralogs
for KIR3DP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
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Genomic Variants
for KIR3DP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for KIR3DP1 (55297807 - 55301870 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 42 variations for KIR3DP1
15/42 CNVs (see all 42): 50215 89325 9816 50217 50223 50222 73425 78276 53768 50218 38822 73431 50220 50219 53576
Locus Specific Mutation Databases (LSDB): KIR3DP1
| SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for KIR3DP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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KIR3DP1 for disorders About GeneDecksing
OMIM gene information: 610604
OMIM disorders: --
10  diseases for KIR3DP1: About MalaCardsvogt-koyanagi-harada disease familial mediterranean fever systemic lupus erythematosus lupus erythematosus
leptospirosis hepatitis c leprosy gastritis
hepatitis leukemia
Human Genome Epidemiology (HuGE) Navigator: KIR3DP1 (39 documents)
Export disorders for KIR3DP1 gene to outside databases
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Publications
for KIR3DP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for KIR3DP1 gene, integrated from 9 sources (see all 43):
(articles sorted by number of sources associating them with KIR3DP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The silent KIR3DP1 gene (CD158c) is transcribed and might encode a secreted receptor in a minority of humans, in whom the KIR3DP1, KIR2DL4 and KIR3DL1/KIR3DS1 genes are duplicated. (PubMed id 15580659)1, 2, 3, 9 Gomez-Lozano N.... Vilches C. (2005)
- Comparative genomic analysis, diversity and evolution of two KIR haplotypes A and B. (PubMed id 15194195)1, 3 Martin A.M....Christiansen F.T. (2004)
- Diversity of killer cell immunoglobulin-like receptor genes in Indonesian populations of Java, Kalimantan, Timor and Irian Jaya. (PubMed id 19000141)1, 9 Velickovic M....Dunckley H. (2009)
- Immunogenetic characteristics of patients with autoim mune gastritis. (PubMed id 20082482)1 Oksanen A.M....Partanen J.A. (2010)
- Distribution of KIR genes in the population of unrela ted individuals homozygous for ancestral haplotype AH8.1 (HLA-A1B8DR3). (PubMed id 20492596)1 Jindra P....Koza V. (2010)
- Effect of killer immunoglobulin-like receptors in the response to combined treatment in patients with chronic hepatitis C virus infe ction. (PubMed id 19846535)1 Vidal-CastiA+eira J.R....LA^pez-Larrea C. (2010)
- Polymorphisms of KIR gene and HLA-C alleles: possible association with susceptibility to HLA-B27-positive patients with ankylosing s pondylitis. (PubMed id 20652381)1 Jiao Y.L....Zhao Y.R. (2010)
- Killer cell immunoglobulin-like receptor gene polymor phisms in patients with leukemia: possible association with susceptibility to t he disease. (PubMed id 19450876)1 Zhang Y....Qi J. (2010)
- Association of KIR2DS1 and KIR2DS3 with fatal outcome in Ebola virus infection. (PubMed id 20878400)1 Wauquier N....Vieillard V. (2010)
- Associations between genes for killer immunoglobulin- like receptors and their ligands in patients with solid tumors. (PubMed id 20600442)1 Al Omar S....Christmas S.E. (2010)
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External Searches for KIR3DP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing KIR3DP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing KIR3DP1 gene
(According to HUGE)
About This Section
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Specialized Databases showing KIR3DP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for KIR3DP1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for KIR3DP1 gene:
Search GeneIP for patents involving KIR3DP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for KIR3DP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KIR3DP1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIR3DP1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIR3DP1 | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIR3DP1 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIR3DP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIR3DP1 |
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 | | | | |  |  |  | | | | ThermoFisher Antibodies for KIR3DP1 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat KIR3DP1 |
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