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Aliases for KIR3DP1 Gene

Aliases for KIR3DP1 Gene

  • Killer Cell Immunoglobulin-Like Receptor, Three Domains, Pseudogene 1 2 3
  • KIR2DS6 3 4 6
  • CD158c 3 4 6
  • KIR48 3 4 6
  • KIRX 3 4 6
  • Killer-Cell Ig-Like Receptor Pseudogene 3
  • CD158c Antigen 4
  • KIR3DS2P 3

External Ids for KIR3DP1 Gene

Previous GeneCards Identifiers for KIR3DP1 Gene

  • GC19P059992
  • GC19U900570
  • GC19P059976
  • GC19P059977
  • GC19P059978
  • GC19P059979
  • GC19P059993
  • GC19P059982
  • GC19P059994
  • GC19P055297
  • GC19P051620

Summaries for KIR3DP1 Gene

Entrez Gene Summary for KIR3DP1 Gene

  • Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. This gene is considered to be a pseudogene based on the absence of transcription and it lacks several functional domains compared to other killer cell immunoglobulin-like receptors. A rare haplotype, the result of a recombinantion event, has two copies of this gene, one of which may encode a secreted protein. (PMID: 15580659)[provided by RefSeq, Mar 2011]

GeneCards Summary for KIR3DP1 Gene

KIR3DP1 (Killer Cell Immunoglobulin-Like Receptor, Three Domains, Pseudogene 1) is a Pseudogene. Diseases associated with KIR3DP1 include hematopoietic stem cell transplantation.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIR3DP1 Gene

Genomics for KIR3DP1 Gene

Genomic Location for KIR3DP1 Gene

Start:
54,786,355 bp from pter
End:
54,790,418 bp from pter
Size:
4,064 bases
Orientation:
Plus strand

Genomic View for KIR3DP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIR3DP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

No data available for Regulatory Elements for KIR3DP1 Gene

Proteins for KIR3DP1 Gene

  • Protein details for KIR3DP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MWS1-KI3P1_HUMAN
    Recommended name:
    Putative killer cell immunoglobulin-like receptor like protein KIR3DP1
    Protein Accession:
    A8MWS1
    Secondary Accessions:

    Protein attributes for KIR3DP1 Gene

    Size:
    328 amino acids
    Molecular mass:
    36055 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • PubMed:15580659, identified a chromosomal rearrangement producing a recombinant gene composed of the promoter and first exon of KIR2DL5A fused to KIR3DP1 which was originally thought to be a pseudogene. This leads to the expression in 4.5 percent of a Spanish Caucasoid population of an mRNA which may encode a chimeric protein KIR2DL5A/KIR3DP1

neXtProt entry for KIR3DP1 Gene

Proteomics data for KIR3DP1 Gene at MOPED

Post-translational modifications for KIR3DP1 Gene

  • Glycosylation at Asn162
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for KIR3DP1 Gene

Domains for KIR3DP1 Gene

Gene Families for KIR3DP1 Gene

HGNC:
  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • KIR :Killer cell immunoglobulin-like receptors

Protein Domains for KIR3DP1 Gene

Suggested Antigen Peptide Sequences for KIR3DP1 Gene

Graphical View of Domain Structure for InterPro Entry

A8MWS1

UniProtKB/Swiss-Prot:

KI3P1_HUMAN :
  • A8MWS1
Domain:
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with KIR3DP1: view

Function for KIR3DP1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KIR3DP1 Gene

Localization for KIR3DP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIR3DP1 Gene

Secreted.

Gene Ontology (GO) - Cellular Components for KIR3DP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with KIR3DP1: view

No data available for Subcellular locations from COMPARTMENTS for KIR3DP1 Gene

Pathways for KIR3DP1 Gene

SuperPathways for KIR3DP1 Gene

No Data Available

Interacting Proteins for KIR3DP1 Gene

Gene Ontology (GO) - Biological Process for KIR3DP1 Gene

None

No data available for Pathways by source for KIR3DP1 Gene

Transcripts for KIR3DP1 Gene

mRNA/cDNA for KIR3DP1 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for KIR3DP1 Gene

No ASD Table

Relevant External Links for KIR3DP1 Gene

GeneLoc Exon Structure for
KIR3DP1
ECgene alternative splicing isoforms for
KIR3DP1

Expression for KIR3DP1 Gene

mRNA expression in normal human tissues for KIR3DP1 Gene

mRNA expression in normal human tissues for KIR3DP1 Gene

mRNA Expression by UniProt/SwissProt for KIR3DP1 Gene

A8MWS1-KI3P1_HUMAN
Tissue specificity: Expressed in peripheral blood cells.
genes like me logo Genes that share expressions with KIR3DP1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein expression for KIR3DP1 Gene

Orthologs for KIR3DP1 Gene

Evolution for KIR3DP1 Gene

ENSEMBL:
Gene Tree for KIR3DP1 (if available)
TreeFam:
Gene Tree for KIR3DP1 (if available)

No data available for Orthologs for KIR3DP1 Gene

Paralogs for KIR3DP1 Gene

genes like me logo Genes that share paralogs with KIR3DP1: view

No data available for Paralogs for KIR3DP1 Gene

Variants for KIR3DP1 Gene

Sequence variations from dbSNP and Humsavar for KIR3DP1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
VAR_059426 -
VAR_059427 -

Relevant External Links for KIR3DP1 Gene

HapMap Linkage Disequilibrium report
KIR3DP1
Locus Specific Mutation Databases (LSDB)
KIR3DP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KIR3DP1 Gene

Disorders for KIR3DP1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for KIR3DP1 Gene including...

Search for KIR3DP1 Gene in MalaCards »

Relevant External Links for KIR3DP1

Genetic Association Database (GAD)
KIR3DP1
Human Genome Epidemiology (HuGE) Navigator
KIR3DP1
genes like me logo Genes that share disorders with KIR3DP1: view

No data available for UniProtKB/Swiss-Prot for KIR3DP1 Gene

Publications for KIR3DP1 Gene

  1. The silent KIR3DP1 gene (CD158c) is transcribed and might encode a secreted receptor in a minority of humans, in whom the KIR3DP1, KIR2DL4 and KIR3DL1/KIR3DS1 genes are duplicated. (PMID: 15580659) Gomez-Lozano N. … Vilches C. (Eur. J. Immunol. 2005) 2 3 4 23
  2. Diversity of killer cell immunoglobulin-like receptor genes in Indonesian populations of Java, Kalimantan, Timor and Irian Jaya. (PMID: 19000141) Velickovic M. … Dunckley H. (Tissue Antigens 2009) 3 23 48
  3. Comparative genomic analysis, diversity and evolution of two KIR haplotypes A and B. (PMID: 15194195) Martin A.M. … Christiansen F.T. (Gene 2004) 2 3
  4. [Polymorphism of killer cell immunoglobulin-like receptors gene family in Zhejiang Han population]. (PMID: 16403292) Zhu F.M. … Yan L.X. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2005) 3 48
  5. KIR genes polymorphism in Argentinean Caucasoid and Amerindian populations. (PMID: 17498266) Flores A.C. … Fainboim L. (Tissue Antigens 2007) 3 48

Products for KIR3DP1 Gene

Sources for KIR3DP1 Gene

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