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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KIR3DP1 Gene

pseudogene   GIFtS: 29
GCID: GC19P055297

Killer Cell Immunoglobulin-Like Receptor, Three Domains,...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Killer Cell Immunoglobulin-Like Receptor, Three Domains, Pseudogene
11 2
     CD158C3 5
KIR2DS62 3 5     CD158c2
KIR482 3 5     KIR3DS2P2
KIRX2 3 5     CD158c Antigen3

External Ids:    HGNC: 163431   Entrez Gene: 5485942   Ensembl: ENSG000002642577   OMIM: 6106045   UniProtKB: A8MWS13   

Export aliases for KIR3DP1 gene to outside databases

Previous GC identifers: GC19P059992 GC19U900570 GC19P059976 GC19P059977 GC19P059978 GC19P059979 GC19P059993 GC19P059982 GC19P059994 GC19P051620


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KIR3DP1 Gene:
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells
and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on
chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster
varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1,
KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or
3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic
domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM),
while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO
protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are
subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the
immune response. This gene is one of the 'framework' loci that is present on all haplotypes. This gene is
considered to be a pseudogene based on the absence of transcription and it lacks several functional domains
compared to other killer cell immunoglobulin-like receptors. A rare haplotype, the result of a recombinantion
event, has two copies of this gene, one of which may encode a secreted protein. (PMID: 15580659)(provided by
RefSeq, Mar 2011)

GeneCards Summary for KIR3DP1 Gene: 
KIR3DP1 (killer cell immunoglobulin-like receptor, three domains, pseudogene 1) is a pseudogene. Diseases associated with KIR3DP1 include leptospirosis, and vogt-koyanagi-harada disease.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for KIR3DP1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKIR3DP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for KIR3DP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIR3DP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.42   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.4

KIR3DP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIR3DP1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P055297:  view genomic region     (about GC identifiers)

Start:
55,297,807 bp from pter      End:
55,301,870 bp from pter
Size:
4,064 bases      Orientation:
plus strand

1 alternative location:
Chr19+,NW_003571060 690,696-694,752     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KI3P1_HUMAN, A8MWS1 (See protein sequence)
Recommended Name: Putative killer cell immunoglobulin-like receptor like protein KIR3DP1 precursor  
Size: 328 amino acids; 36055 Da
Subcellular location: Secreted (Potential)
Miscellaneous: PubMed:15580659, identified a chromosomal rearrangement producing a recombinant gene composed of
the promoter and first exon of KIR2DL5A fused to KIR3DP1 which was originally thought to be a pseudogene. This
leads to the expression in 4.5 percent of a Spanish Caucasoid population of an mRNA which may encode a chimeric
protein KIR2DL5A/KIR3DP1

Explore the universe of human proteins at neXtProt for KIR3DP1: NX_A8MWS1

KIR3DP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

KIR3DP1 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
CD: CD molecules
KIR: Killer cell immunoglobulin-like receptors
IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

4 InterPro protein domains:
 IPR003598 Ig_sub2
 IPR003599 Ig_sub
 IPR013783 Ig-like_fold
 IPR013151 Immunoglobulin

Graphical View of Domain Structure for InterPro Entry A8MWS1

ProtoNet protein and cluster: A8MWS1

UniProtKB/Swiss-Prot: KI3P1_HUMAN, A8MWS1
Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains


KIR3DP1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KIR3DP1

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
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Search CenterWatch for drugs/clinical trials and news about KIR3DP1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KIR3DP1 gene: 
NM_001015070.1  

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000580853
miRNA
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KIR3DP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTCCTGAGGC
KIR3DP1 Expression
About this image

UniProtKB/Swiss-Prot: KI3P1_HUMAN, A8MWS1
Tissue specificity: Expressed in peripheral blood cells

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIR3DP1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
  --

ENSEMBL Gene Tree for KIR3DP1 (if available)
TreeFam Gene Tree for KIR3DP1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for KIR3DP1 gene
18/54 SIMAP similar genes for KIR3DP1 using alignment to 1 protein entry:     KI3P1_HUMAN(see all similar genes):
p58    1060P11.3    KIR222    KIR-K36    KIR-K9    KIR2DL1
KIR2DL2    KIR-G1    KIR-G2    KIR-K15    KIR-K3    KIR-K64
KIR2DL3    KIR2DP1DL1    KIR2DS2S3    KIR412    NKAT2a-delta-Ig2    1060P11.7

KIR3DP1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

2 SNPs in KIR3DP1 are shown    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0594274
----see VAR_0594272 E D mis40--------
VAR_0594264
----see VAR_0594262 K T mis40--------

HapMap Linkage Disequilibrium report for KIR3DP1 (55297807 - 55301870 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for KIR3DP1: --

Locus Specific Mutation Databases (LSDB): KIR3DP1
SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 610604    OMIM disorders: --

11 diseases for KIR3DP1:    About MalaCards
leptospirosis    vogt-koyanagi-harada disease    hematopoietic stem cell transplantation    familial mediterranean fever
leprosy    gastritis    systemic lupus erythematosus    hepatitis c
lupus erythematosus    hepatitis    leukemia


KIR3DP1 for disorders           About GeneDecksing

Genetic Association Database (GAD): KIR3DP1
Human Genome Epidemiology (HuGE) Navigator: KIR3DP1 (39 documents)

Export disorders for KIR3DP1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for KIR3DP1 gene, integrated from 9 sources (see all 44):
(articles sorted by number of sources associating them with KIR3DP1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The silent KIR3DP1 gene (CD158c) is transcribed and might encode a secreted receptor in a minority of humans, in whom the KIR3DP1, KIR2DL4 and KIR3DL1/KIR3DS1 genes are duplicated. (PubMed id 15580659)1, 2, 3, 9 Gomez-Lozano N.... Vilches C. (2005)
  2. Diversity of killer cell immunoglobulin-like receptor genes in Indonesian populations of Java, Kalimantan, Timor and Irian Jaya. (PubMed id 19000141)1, 4, 9 Velickovic M....Dunckley H. (2009)
  3. Immunogenetic characteristics of patients with autoim mune gastritis. (PubMed id 20082482)1, 4 Oksanen A.M....Partanen J.A. (2010)
  4. Effect of killer immunoglobulin-like receptors in the response to combined treatment in patients with chronic hepatitis C virus infe ction. (PubMed id 19846535)1, 4 Vidal-CastiA+eira J.R....LA^pez-Larrea C. (2010)
  5. Killer cell immunoglobulin-like receptor gene polymor phisms in patients with leukemia: possible association with susceptibility to t he disease. (PubMed id 19450876)1, 4 Zhang Y....Qi J. (2010)
  6. Association of KIR2DS1 and KIR2DS3 with fatal outcome in Ebola virus infection. (PubMed id 20878400)1, 4 Wauquier N....Vieillard V. (2010)
  7. Killer cell immunoglobulin-like receptor gene-cluster 3DS1-2DL5-2DS1-2DS5 predisposes susceptibility to Vogt-Koyanagi-Harada syndrom e in Japanese individuals. (PubMed id 19897003)1, 4 Levinson R.D....Rajalingam R. (2010)
  8. Activating killer cell immunoglobulin-like receptors 3DS1 and 2DS1 protect against developing the severe form of recurrent respirato ry papillomatosis. (PubMed id 19861144)1, 4 Bonagura V.R....Rajalingam R. (2010)
  9. Activating killer cell immunoglobulin-like receptor g enes' association with recurrent miscarriage. (PubMed id 19527230)1, 4 Vargas R.G....da GraAsa Bicalho M. (2009)
  10. KIR genes and KIR ligands affect occurrence of acute GVHD after unrelated, 12/12 HLA matched, hematopoietic stem cell transplantation. (PubMed id 19169284)1, 4 Ludajic K....Greinix H.T. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 548594 HGNC: 16343 Ensembl:ENSG00000264257 euGenes: HUgn548594 ECgene: KIR3DP1
H-InvDB: KIR3DP1

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for KIR3DP1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for KIR3DP1 gene:
Search GeneIP for patents involving KIR3DP1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section

 
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 Search for Antibodies for KIR3DP1 at Abcam
 See all of Abcam's Antibodies, Kits and Proteins for KIR3DP1
 Custom Antibody / Protein Production Service
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 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins




 Browse Proteins at Cloud-Clone Corp.
 Browse Antibodies at Cloud-Clone Corp.
 Browse ELISAs at Cloud-Clone Corp.
 Browse CLIAs at Cloud-Clone Corp.
 Search LifeMap BioReagents cell lines for KIR3DP1
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIR3DP1
 SwitchGear 3'UTR luciferase reporter plasmids for KIR3DP1
 SwitchGear Promoter luciferase reporter plasmids for KIR3DP1
 ThermoFisher Antibodies for KIR3DP1
 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat KIR3DP1
 inGenious Targeting Laboratory - Custom generated mouse model solutions for KIR3DP1
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KIR3DP1
Customized:
 lentivirus for stable overexpression of KIR3DP1
 lentivirus expression plasmids for stable overexpression of KIR3DP1
 adenovirus for overexpression of KIR3DP1
 Search LSBio for Antibodies for KIR3DP1
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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