Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KIR3DL3 Gene

Aliases for KIR3DL3 Gene

  • Killer Cell Immunoglobulin Like Receptor, Three Ig Domains And Long Cytoplasmic Tail 3 2 3 5
  • Killer Cell Immunoglobulin-Like Receptor, Three Domains, Long Cytoplasmic Tail, 3 2 3
  • CD158 Antigen-Like Family Member Z 3 4
  • Killer Cell Inhibitory Receptor 1 3 4
  • KIR3DL7 3 4
  • CD158Z 3 4
  • KIRC1 3 4
  • Killer Cell Immunoglobulin-Like Receptor 3DL3 3
  • Killer-Cell Immunoglobulin-Like Receptor 3DL3 3
  • Killer Cell Ig-Like Receptor KIR3DL7 3
  • CD158z Antigen 4
  • KIR44 3

External Ids for KIR3DL3 Gene

Previous GeneCards Identifiers for KIR3DL3 Gene

  • GC19P059927
  • GC00P9Q0007
  • GC19P055238
  • GC19P055241
  • GC19P051558
  • GC19P055244
  • GC19P055249
  • GC19P055254
  • GC19P055259
  • GC19P055263
  • GC19P055270
  • GC19P054839
  • GC19P054909
  • GC19P054928
  • GC19P054944
  • GC19P054969

Summaries for KIR3DL3 Gene

Entrez Gene Summary for KIR3DL3 Gene

  • Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. [provided by RefSeq, Jul 2008]

GeneCards Summary for KIR3DL3 Gene

KIR3DL3 (Killer Cell Immunoglobulin Like Receptor, Three Ig Domains And Long Cytoplasmic Tail 3) is a Protein Coding gene. Among its related pathways are Natural Killer Cell Receptors: Human Target Cell – NK Cell Ligand-Receptor Interactions and Allograft rejection. An important paralog of this gene is KIR3DL2.

UniProtKB/Swiss-Prot for KIR3DL3 Gene

  • Receptor on natural killer cells. May inhibit the activity of NK cells thus preventing cell lysis.

Gene Wiki entry for KIR3DL3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIR3DL3 Gene

Genomics for KIR3DL3 Gene

Regulatory Elements for KIR3DL3 Gene

Enhancers for KIR3DL3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G054695 0.9 Ensembl 12.3 -27.5 -27547 2.2 ARID4B ZNF48 TCF12 GATA2 ZNF263 ZNF592 CREB3 SMARCA4 ETV4 PBX2 KIR3DL3 KIR2DL3 KIR2DL4 KIR3DL1 KIR3DX1 GP6 LILRP1 ENSG00000228790
GH19G054792 0.8 Ensembl 11.2 +68.5 68454 1.0 ATF1 IRF2 HINFP CREB3L1 SUZ12 DEAF1 ZNF644 ZNF766 ELK1 ZNF143 KIR2DL3 KIR3DL1 KIR3DL3 NLRP2 NLRP7 ENSG00000243494 KIR3DX1 EPS8L1 RDH13 KIR3DP1
GH19G054368 1.8 FANTOM5 Ensembl ENCODE dbSUPER 1.5 -351.6 -351612 8.9 HDGF PKNOX1 YY1 ZNF766 ZNF143 JUNB REST TBX21 MAFF ATF4 FCAR LAIR1 LILRB2 OSCAR LILRA5 VSTM1 LILRB3 LILRB4 LILRB1 LILRA2
GH19G054859 1 FANTOM5 ENCODE 2.4 +135.2 135205 0.4 ZBTB10 RFX1 ZNF48 MCM7 FOSL1 ZNF366 NFE2 FOS EMSY EZH2 FCAR TNNT1 TMEM86B LAIR1 LILRB1 LILRA1 LILRA2 TMEM150B LILRB4 PPP1R12C
GH19G054660 1.6 FANTOM5 Ensembl ENCODE 1.5 -62.2 -62151 4.2 HDGF ATF1 PKNOX1 CREB3L1 ARNT WRNIP1 SIN3A GLI4 GLIS2 FOS LILRB4 FCAR LAIR1 LILRB1 KIR3DX1 LILRB2 KIR2DL3 LILRA5 LILRB3 LILRA1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KIR3DL3 on UCSC Golden Path with GeneCards custom track

Genomic Location for KIR3DL3 Gene

Chromosome:
19
Start:
54,724,447 bp from pter
End:
54,736,536 bp from pter
Size:
12,090 bases
Orientation:
Plus strand

Genomic View for KIR3DL3 Gene

Genes around KIR3DL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIR3DL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIR3DL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for KIR3DL3 Gene

  • Protein details for KIR3DL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N743-KI3L3_HUMAN
    Recommended name:
    Killer cell immunoglobulin-like receptor 3DL3
    Protein Accession:
    Q8N743
    Secondary Accessions:
    • A9PL62
    • A9PL64
    • A9PL65
    • A9PL66
    • A9PL67
    • A9PL68
    • A9PZV4
    • A9PZV7
    • A9PZV8
    • A9Q066
    • A9Q0R5
    • A9Q242
    • A9Q250
    • A9Q251
    • O95056
    • Q1X775
    • Q1X777
    • Q1X778
    • Q1X779
    • Q1X780
    • Q1X781
    • Q1X782
    • Q1X783
    • Q7Z7N4
    • Q8NHI2
    • Q8NHI3
    • Q9UEI4

    Protein attributes for KIR3DL3 Gene

    Size:
    410 amino acids
    Molecular mass:
    44928 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KIR3DL3 Gene

Post-translational modifications for KIR3DL3 Gene

  • Glycosylation at isoforms=179, posLast=239239, and posLast=273273
  • Modification sites at PhosphoSitePlus

Other Protein References for KIR3DL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for KIR3DL3 (KIR3DL3/CD158z)
  • Cloud-Clone Corp. Antibodies for KIR3DL3
  • Santa Cruz Biotechnology (SCBT) Antibodies for KIR3DL3

No data available for DME Specific Peptides for KIR3DL3 Gene

Domains & Families for KIR3DL3 Gene

Protein Domains for KIR3DL3 Gene

Suggested Antigen Peptide Sequences for KIR3DL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N743

UniProtKB/Swiss-Prot:

KI3L3_HUMAN :
  • Belongs to the immunoglobulin superfamily.
Family:
  • Belongs to the immunoglobulin superfamily.
genes like me logo Genes that share domains with KIR3DL3: view

Function for KIR3DL3 Gene

Molecular function for KIR3DL3 Gene

UniProtKB/Swiss-Prot Function:
Receptor on natural killer cells. May inhibit the activity of NK cells thus preventing cell lysis.
genes like me logo Genes that share phenotypes with KIR3DL3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KIR3DL3 Gene

Localization for KIR3DL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIR3DL3 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIR3DL3 gene
Compartment Confidence
plasma membrane 5
extracellular 2
lysosome 1

Gene Ontology (GO) - Cellular Components for KIR3DL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KIR3DL3: view

Pathways & Interactions for KIR3DL3 Gene

genes like me logo Genes that share pathways with KIR3DL3: view

Pathways by source for KIR3DL3 Gene

Interacting Proteins for KIR3DL3 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 13)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000291860%0d%0a9606.ENSP00000342215%0d%0a9606.ENSP00000262629%0d%0a9606.ENSP00000365402%0d%0a9606.ENSP00000253362%0d%0a9606.ENSP00000336769%0d%0a
Selected Interacting proteins: ENSP00000291860 Q8N743-KI3L3_HUMAN for KIR3DL3 Gene via STRING IID

Gene Ontology (GO) - Biological Process for KIR3DL3 Gene

None

No data available for SIGNOR curated interactions for KIR3DL3 Gene

Drugs & Compounds for KIR3DL3 Gene

(1) Drugs for KIR3DL3 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
BMS-986015 Pharma activator NK cell activator 0
genes like me logo Genes that share compounds with KIR3DL3: view

Transcripts for KIR3DL3 Gene

mRNA/cDNA for KIR3DL3 Gene

(1) REFSEQ mRNAs :
(18) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KIR3DL3 Gene

Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIR3DL3 Gene

No ASD Table

Relevant External Links for KIR3DL3 Gene

GeneLoc Exon Structure for
KIR3DL3
ECgene alternative splicing isoforms for
KIR3DL3

Expression for KIR3DL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIR3DL3 Gene

Protein differential expression in normal tissues from HIPED for KIR3DL3 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KIR3DL3 Gene



Protein tissue co-expression partners for KIR3DL3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KIR3DL3 Gene:

KIR3DL3

SOURCE GeneReport for Unigene cluster for KIR3DL3 Gene:

Hs.645224

Evidence on tissue expression from TISSUES for KIR3DL3 Gene

  • Blood(2.2)
genes like me logo Genes that share expression patterns with KIR3DL3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIR3DL3 Gene

Orthologs for KIR3DL3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIR3DL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIR3DL3 34
  • 97.48 (n)
-- 35
  • 91 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Kir3dl2 34 16 35
  • 64.33 (n)
Kir3dl1 35
  • 41 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Kir3dl1 34
  • 62 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 31 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 29 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 28 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 19 (a)
ManyToMany
-- 35
  • 15 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 16 (a)
OneToMany
Species where no ortholog for KIR3DL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KIR3DL3 Gene

ENSEMBL:
Gene Tree for KIR3DL3 (if available)
TreeFam:
Gene Tree for KIR3DL3 (if available)

Paralogs for KIR3DL3 Gene

genes like me logo Genes that share paralogs with KIR3DL3: view

Variants for KIR3DL3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for KIR3DL3 Gene

KI3L3_HUMAN-Q8N743
Various different KIR3DL3 alleles are known: KIR3DL3*00101, KIR3DL3*00102, KIR3DL3*00103, KIR3DL3*00201, KIR3DL3*00202, KIR3DL3*00203, KIR3DL3*00204, KIR3DL3*00205, KIR3DL3*00206, KIR3DL3*00207, KIR3DL3*0030101 KIR3DL3*0030102, KIR3DL3*00401, KIR3DL3*00402, KIR3DL3*005, KIR3DL3*00601, KIR3DL3*00602, KIR3DL3*007, KIR3DL3*00801, KIR3DL3*00802, KIR3DL3*00901, KIR3DL3*00902, KIR3DL3*010, KIR3DL3*01101, KIR3DL3*01102, KIR3DL3*012, KIR3DL3*01301, KIR3DL3*01302, KIR3DL3*01303, KIR3DL3*01304, KIR3DL3*01305, KIR3DL3*01306, KIR3DL3*01307, KIR3DL3*01401, KIR3DL3*01402, KIR3DL3*01403, KIR3DL3*01404, KIR3DL3*01405, KIR3DL3*015 KIR3DL3*016, KIR3DL3*017, KIR3DL3*018, KIR3DL3*019, KIR3DL3*020, KIR3DL3*021, KIR3DL3*022, KIR3DL3*023, KIR3DL3*024, KIR3DL3*025, KIR3DL3*026, KIR3DL3*027, KIR3DL3*028, KIR3DL3*029, KIR3DL3*030 and KIR3DL3*031. The sequence shown corresponds to the alleles KIR3DL3*002.

Sequence variations from dbSNP and Humsavar for KIR3DL3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs113170354 -- 54,729,004(+) AAAGA(A/C)AGATA intron-variant
rs113988102 --
rs148747226 -- 54,729,001(+) TAGAA(-/AGAC)AGATA intron-variant
rs16985907 --
rs184404357 -- 54,729,002(+) AGAAA(A/G)ACAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIR3DL3 Gene

Variant ID Type Subtype PubMed ID
dgv1078e212 CNV gain 25503493
dgv1079e212 CNV loss 25503493
dgv1080e212 CNV loss 25503493
dgv16e196 CNV duplication 17116639
dgv17e196 CNV deletion 17116639
dgv3666n100 CNV gain 25217958
dgv3667n100 CNV gain 25217958
dgv3668n100 CNV loss 25217958
dgv3669n100 CNV gain 25217958
dgv3670n100 CNV loss 25217958
dgv3671n100 CNV gain+loss 25217958
dgv534e201 CNV deletion 23290073
dgv535e201 CNV deletion 23290073
dgv536e201 CNV deletion 23290073
dgv6564n54 CNV gain 21841781
dgv667e199 CNV deletion 23128226
dgv672e214 CNV loss 21293372
dgv76e203 CNV gain+loss 21179565
esv26630 CNV gain+loss 19812545
esv2667609 CNV deletion 23128226
esv2668465 CNV deletion 23128226
esv2718872 CNV deletion 23290073
esv2718910 CNV deletion 23290073
esv2758771 CNV gain+loss 17122850
esv32828 CNV loss 17666407
nsv1071948 CNV deletion 25765185
nsv1126531 CNV deletion 24896259
nsv1133455 CNV deletion 24896259
nsv428372 CNV gain+loss 18775914
nsv437834 CNV loss 16327808
nsv469656 CNV loss 16826518
nsv471706 CNV loss 15918152
nsv517143 CNV gain+loss 19592680
nsv580245 CNV loss 21841781
nsv580246 CNV gain 21841781
nsv833879 CNV gain+loss 17160897
nsv9761 CNV gain+loss 18304495
nsv978852 CNV duplication 23825009

Variation tolerance for KIR3DL3 Gene

Gene Damage Index Score: 4.03; 60.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIR3DL3 Gene

Human Gene Mutation Database (HGMD)
KIR3DL3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIR3DL3

Disorders for KIR3DL3 Gene

Relevant External Links for KIR3DL3

Genetic Association Database (GAD)
KIR3DL3
Human Genome Epidemiology (HuGE) Navigator
KIR3DL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIR3DL3

No disorders were found for KIR3DL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIR3DL3 Gene

Publications for KIR3DL3 Gene

  1. Diversity of killer cell immunoglobulin-like receptor genes in Indonesian populations of Java, Kalimantan, Timor and Irian Jaya. (PMID: 19000141) Velickovic M. … Dunckley H. (Tissue Antigens 2009) 3 22 46 64
  2. Asian population frequencies and haplotype distribution of killer cell immunoglobulin-like receptor (KIR) genes among Chinese, Malay, and Indian in Singapore. (PMID: 18668235) Lee Y.C. … Ren E.C. (Immunogenetics 2008) 3 22 46 64
  3. Polymorphisms of killer cell immunoglobulin-like receptor gene: possible association with susceptibility to or clearance of hepatitis B virus infection in Chinese Han population. (PMID: 18074414) Zhi-ming L. … Yue-ran Z. (Croat. Med. J. 2007) 3 22 46 64
  4. Inhibition of natural killer cell activation signals by killer cell immunoglobulin-like receptors (CD158). (PMID: 11513144) Long E.O. … Watzl C. (Immunol. Rev. 2001) 2 3 4 64
  5. Immunogenetic characteristics of patients with autoimmune gastritis. (PMID: 20082482) Oksanen A.M. … Partanen J.A. (World J. Gastroenterol. 2010) 3 46 64

Products for KIR3DL3 Gene

Sources for KIR3DL3 Gene

Content
Loading form....