Aliases for KIR3DL3 Gene
External Ids for KIR3DL3 Gene
Previous GeneCards Identifiers for KIR3DL3 Gene
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. [provided by RefSeq, Jul 2008]
GeneCards Summary for KIR3DL3 Gene
KIR3DL3 (Killer Cell Immunoglobulin Like Receptor, Three Ig Domains And Long Cytoplasmic Tail 3) is a Protein Coding gene. Diseases associated with KIR3DL3 include Duane Retraction Syndrome. Among its related pathways are Allograft rejection and Natural Killer Cell Receptors: Human Target Cell – NK Cell Ligand-Receptor Interactions. An important paralog of this gene is KIR3DL2.
UniProtKB/Swiss-Prot for KIR3DL3 Gene
Receptor on natural killer cells. May inhibit the activity of NK cells thus preventing cell lysis.