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Aliases for KIR3DL3 Gene

Aliases for KIR3DL3 Gene

  • Killer Cell Immunoglobulin-Like Receptor, Three Domains, Long Cytoplasmic Tail, 3 2 3
  • KIR3DL7 3 4 6
  • KIRC1 3 4 6
  • CD158 Antigen-Like Family Member Z 3 4
  • Killer Cell Inhibitory Receptor 1 3 4
  • CD158Z 3 4
  • KIR44 3 6
  • Killer Cell Immunoglobulin-Like Receptor 3DL3 3
  • Killer Cell Ig-Like Receptor KIR3DL7 3
  • CD158z Antigen 4
  • KIR3KL3 6

External Ids for KIR3DL3 Gene

Previous GeneCards Identifiers for KIR3DL3 Gene

  • GC19P059927
  • GC00P9Q0007
  • GC19P055238
  • GC19P055241
  • GC19P051558
  • GC19P055244
  • GC19P055249
  • GC19P055254
  • GC19P055259
  • GC19P055263
  • GC19P055270

Summaries for KIR3DL3 Gene

Entrez Gene Summary for KIR3DL3 Gene

  • Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. [provided by RefSeq, Jul 2008]

GeneCards Summary for KIR3DL3 Gene

KIR3DL3 (Killer Cell Immunoglobulin-Like Receptor, Three Domains, Long Cytoplasmic Tail, 3) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is KIR2DL4.

UniProtKB/Swiss-Prot for KIR3DL3 Gene

  • Receptor on natural killer cells. May inhibit the activity of NK cells thus preventing cell lysis.

Gene Wiki entry for KIR3DL3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIR3DL3 Gene

Genomics for KIR3DL3 Gene

Regulatory Elements for KIR3DL3 Gene

Genomic Location for KIR3DL3 Gene

54,724,479 bp from pter
54,736,536 bp from pter
12,058 bases
Plus strand

Genomic View for KIR3DL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIR3DL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for KIR3DL3 Gene

  • Protein details for KIR3DL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Killer cell immunoglobulin-like receptor 3DL3
    Protein Accession:
    Secondary Accessions:
    • A9PL62
    • A9PL64
    • A9PL65
    • A9PL66
    • A9PL67
    • A9PL68
    • A9PZV4
    • A9PZV7
    • A9PZV8
    • A9Q066
    • A9Q0R5
    • A9Q242
    • A9Q250
    • A9Q251
    • O95056
    • Q1X775
    • Q1X777
    • Q1X778
    • Q1X779
    • Q1X780
    • Q1X781
    • Q1X782
    • Q1X783
    • Q7Z7N4
    • Q8NHI2
    • Q8NHI3
    • Q9UEI4

    Protein attributes for KIR3DL3 Gene

    410 amino acids
    Molecular mass:
    44928 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KIR3DL3 Gene

Proteomics data for KIR3DL3 Gene at MOPED

Post-translational modifications for KIR3DL3 Gene

  • Glycosylation at Asn179, Asn239, and Asn273
  • Modification sites at PhosphoSitePlus

Other Protein References for KIR3DL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KIR3DL3 Gene

Domains for KIR3DL3 Gene

Protein Domains for KIR3DL3 Gene

Suggested Antigen Peptide Sequences for KIR3DL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily.
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily.
genes like me logo Genes that share domains with KIR3DL3: view

Function for KIR3DL3 Gene

Molecular function for KIR3DL3 Gene

UniProtKB/Swiss-Prot Function:
Receptor on natural killer cells. May inhibit the activity of NK cells thus preventing cell lysis.

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIR3DL3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KIR3DL3 Gene

Localization for KIR3DL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIR3DL3 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for KIR3DL3 Gene COMPARTMENTS Subcellular localization image for KIR3DL3 gene
Compartment Confidence
plasma membrane 5
extracellular 2
lysosome 1

Gene Ontology (GO) - Cellular Components for KIR3DL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KIR3DL3: view

Pathways for KIR3DL3 Gene

genes like me logo Genes that share pathways with KIR3DL3: view

Pathways by source for KIR3DL3 Gene

Interacting Proteins for KIR3DL3 Gene

Gene Ontology (GO) - Biological Process for KIR3DL3 Gene


Transcripts for KIR3DL3 Gene

mRNA/cDNA for KIR3DL3 Gene

(1) REFSEQ mRNAs :
(18) Additional mRNA sequences :
(93) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KIR3DL3 Gene

Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIR3DL3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIR3DL3 Gene

No ASD Table

Relevant External Links for KIR3DL3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KIR3DL3 Gene

mRNA expression in normal human tissues for KIR3DL3 Gene

Protein differential expression in normal tissues for KIR3DL3 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for KIR3DL3 Gene

SOURCE GeneReport for Unigene cluster for KIR3DL3 Gene Hs.645224

genes like me logo Genes that share expressions with KIR3DL3: view

Expression partners for KIR3DL3 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KIR3DL3 Gene

Orthologs for KIR3DL3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIR3DL3 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Kir3dl2 35
  • 64.33 (n)
  • 45.38 (a)
Kir3dl1 36
  • 41 (a)
Kir3dl2 36
  • 41 (a)
(Pan troglodytes)
Mammalia KIR3DL3 35
  • 97.48 (n)
  • 95.24 (a)
-- 36
  • 91 (a)
(Rattus norvegicus)
Mammalia Kir3dl1 35
  • 62 (n)
  • 41.28 (a)
(Bos Taurus)
Mammalia -- 36
  • 28 (a)
(Canis familiaris)
Mammalia -- 36
  • 31 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 29 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 19 (a)
-- 36
  • 15 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 16 (a)
Species with no ortholog for KIR3DL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KIR3DL3 Gene

Gene Tree for KIR3DL3 (if available)
Gene Tree for KIR3DL3 (if available)

Paralogs for KIR3DL3 Gene

genes like me logo Genes that share paralogs with KIR3DL3: view

Variants for KIR3DL3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for KIR3DL3 Gene

Various different KIR3DL3 alleles are known: KIR3DL3*00101, KIR3DL3*00102, KIR3DL3*00103, KIR3DL3*00201, KIR3DL3*00202, KIR3DL3*00203, KIR3DL3*00204, KIR3DL3*00205, KIR3DL3*00206, KIR3DL3*00207, KIR3DL3*0030101 KIR3DL3*0030102, KIR3DL3*00401, KIR3DL3*00402, KIR3DL3*005, KIR3DL3*00601, KIR3DL3*00602, KIR3DL3*007, KIR3DL3*00801, KIR3DL3*00802, KIR3DL3*00901, KIR3DL3*00902, KIR3DL3*010, KIR3DL3*01101, KIR3DL3*01102, KIR3DL3*012, KIR3DL3*01301, KIR3DL3*01302, KIR3DL3*01303, KIR3DL3*01304, KIR3DL3*01305, KIR3DL3*01306, KIR3DL3*01307, KIR3DL3*01401, KIR3DL3*01402, KIR3DL3*01403, KIR3DL3*01404, KIR3DL3*01405, KIR3DL3*015 KIR3DL3*016, KIR3DL3*017, KIR3DL3*018, KIR3DL3*019, KIR3DL3*020, KIR3DL3*021, KIR3DL3*022, KIR3DL3*023, KIR3DL3*024, KIR3DL3*025, KIR3DL3*026, KIR3DL3*027, KIR3DL3*028, KIR3DL3*029, KIR3DL3*030 and KIR3DL3*031. The sequence shown corresponds to the alleles KIR3DL3*002

Sequence variations from dbSNP and Humsavar for KIR3DL3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs270786 -- 54,722,714(+) agaaa(A/G)catcc upstream-variant-2KB
rs270787 -- 54,724,014(+) attgc(A/G)tctca upstream-variant-2KB
rs270788 -- 54,725,165(+) ACGGA(A/G)GTGGA intron-variant
rs270789 -- 54,726,404(+) GGGGg(C/T)gtcca intron-variant
rs270790 - 54,727,757(+) GCCTC(A/G)TTGGA missense, reference

Structural Variations from Database of Genomic Variants (DGV) for KIR3DL3 Gene

Variant ID Type Subtype PubMed ID
dgv1119e1 CNV Complex 17122850
esv2667609 CNV Deletion 23128226
esv2718872 CNV Deletion 23290073
dgv16e196 CNV Duplication 17116639
dgv17e196 CNV Deletion 17116639
dgv1126e1 CNV Complex 17122850
nsv428372 CNV Gain+Loss 18775914
nsv833879 CNV Gain+Loss 17160897
dgv1127e1 CNV Complex 17122850
dgv1128e1 CNV Complex 17122850
nsv469656 CNV Gain 16826518
nsv471706 CNV Loss 15918152
nsv437834 CNV Loss 16327808
dgv667e199 CNV Deletion 23128226
nsv517143 CNV Gain+Loss 19592680
dgv4007n71 CNV Gain+Loss 21882294
dgv4008n71 CNV Gain 21882294
esv2668465 CNV Deletion 23128226
esv2718910 CNV Deletion 23290073
dgv575e201 CNV Deletion 23290073
esv26630 CNV Gain+Loss 19812545
dgv576e201 CNV Deletion 23290073
nsv9761 CNV Gain+Loss 18304495
dgv577e201 CNV Deletion 23290073
esv32828 CNV Loss 17666407

Relevant External Links for KIR3DL3 Gene

HapMap Linkage Disequilibrium report
Locus Specific Mutation Databases (LSDB)

Disorders for KIR3DL3 Gene

Relevant External Links for KIR3DL3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for KIR3DL3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for KIR3DL3 Gene

Publications for KIR3DL3 Gene

  1. Polymorphisms of killer cell immunoglobulin-like receptor gene: possible association with susceptibility to or clearance of hepatitis B virus infection in Chinese Han population. (PMID: 18074414) Zhi-ming L. … Yue-ran Z. (Croat. Med. J. 2007) 3 23 48
  2. Asian population frequencies and haplotype distribution of killer cell immunoglobulin-like receptor (KIR) genes among Chinese, Malay, and Indian in Singapore. (PMID: 18668235) Lee Y.C. … Ren E.C. (Immunogenetics 2008) 3 23 48
  3. Diversity of killer cell immunoglobulin-like receptor genes in Indonesian populations of Java, Kalimantan, Timor and Irian Jaya. (PMID: 19000141) Velickovic M. … Dunckley H. (Tissue Antigens 2009) 3 23 48
  4. Inhibition of natural killer cell activation signals by killer cell immunoglobulin-like receptors (CD158). (PMID: 11513144) Long E.O. … Watzl C. (Immunol. Rev. 2001) 2 3 4
  5. Natural killer immunoglobulin-like receptor (KIR) locus profiles in African and South Asian populations. (PMID: 11960306) Norman P.J. … Vaughan R.W. (Genes Immun. 2002) 3 4

Products for KIR3DL3 Gene

Sources for KIR3DL3 Gene

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