Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KIR3DL2 Gene

protein-coding   GIFtS: 53
GCID: GC19P055361

killer cell immunoglobulin-like receptor, three domains,...

 Explore 34 diseases affiliated with
KIR3DL2 via our new
 Human Malady Compendium 
Biological research products
for KIR3DL2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Killer Cell Immunoglobulin-Like Receptor, Three Domains, Long Cytoplasmic
Tail, 21 2
     Nkat4a1
CD158K1 2 3     Nkat4b1
NKAT42 3 5     NKAT4B2
Natural Killer-Associated Transcript 42 3     Killer Cell Immunoglobulin-Like Receptor 3DL22
NKAT-42 3     Killer Cell Immunoglobulin-Like Receptor KIR3DL22
CD158 Antigen-Like Family Member K2 3     Killer Ig Receptor2
MHC Class I NK Cell Receptor2 3     KIR Antigen 3DL22
P70 Natural Killer Cell Receptor Clone CL-52 3     Natural Killer Cell Inhibitory Receptor2
P70 NK Receptor CL-52 3     P1401
Cl-51     P70 Killer Cell Inhibitory Receptor2
Nkat41     CD158k Antigen3

External Ids:    HGNC: 63391   Entrez Gene: 38122   Ensembl: ENSG000002404037   OMIM: 6049475   UniProtKB: P436303   

Export aliases for KIR3DL2 gene to outside databases

Previous GC identifers: GC19U990058 GC19P055664 GC19P060005 GC19P060010 GC19P060053 GC19P059939 GC19P051684


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KIR3DL2:
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and
subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome
19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among
haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The
KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have
a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals
upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short
cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to
transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR
proteins are thought to play an important role in regulation of the immune response. This gene is one of the
'framework' loci that is present on all haplotypes. Alternatively spliced transcript variants encoding multiple
isoforms have been observed for this gene. (provided by RefSeq, Jun 2011)

UniProtKB/Swiss-Prot: KI3L2_HUMAN, P43630
Function: Receptor on natural killer (NK) cells for HLA-A alleles. Inhibits the activity of NK cells thus preventing
cell lysis

Gene Wiki entry for KIR3DL2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KIR3DL2 gene promoter:
         CREB   GATA-3   p53   deltaCREB   CUTL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKIR3DL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for KIR3DL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIR3DL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.4

KIR3DL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIR3DL2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P055361:  view genomic region     (about GC identifiers)

Start:
55,361,898 bp from pter      End:
55,378,662 bp from pter
Size:
16,765 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KI3L2_HUMAN, P43630 (See protein sequence)
Recommended Name: Killer cell immunoglobulin-like receptor 3DL2 precursor  
Size: 455 amino acids; 50230 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein
Secondary accessions: Q13238 Q14947 Q14948 Q92684 Q95367 Q95368

Explore the universe of human proteins at neXtProt for KIR3DL2: NX_P43630

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P43630

  • KIR3DL2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001229796.1  NP_006728.2  

    ENSEMBL proteins: 
     ENSP00000325525   ENSP00000270442  
    Reactome Protein details: P43630
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for KIR3DL2 (KIR3DL2/CD158k)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: KIR3DL2
    OriGene Custom Protein Services for KIR3DL2 
    GenScript Custom Purified and Recombinant Proteins Services for KIR3DL2
    Novus Biologicals KIR3DL2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for KIR3DL2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS7716543


    KIR3DL2 for ontologies           About GeneDecksing



    KIR3DL2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for KIR3DL2 (KIR3DL2/CD158k)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for KIR3DL2 
    GenScript Custom Superior Antibodies Services for KIR3DL2
    Search for Antibodies for KIR3DL2 at Abcam  
    Uscn Antibodies for KIR3DL2
    ThermoFisher Antibodies for KIR3DL2

    Assay Products for KIR3DL2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KIR3DL2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for KIR3DL2


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    KIR3DL2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR013783 Ig-like_fold
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P43630

    ProtoNet protein and cluster: P43630

    1 Blocks protein family: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: KI3L2_HUMAN, P43630
    Similarity: Belongs to the immunoglobulin superfamily
    Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: KI3L2_HUMAN, P43630
    Function: Receptor on natural killer (NK) cells for HLA-A alleles. Inhibits the activity of NK cells thus preventing
    cell lysis

         Genatlas biochemistry entry for KIR3DL2:
    natural killer cell immunoglobulin-like inhibitory receptor for HLA-B antigens,3DL2,70kDa,with several alternatively
    spliced (truncated) forms

    miRNA
    Products:
        
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KIR3DL2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate KIR3DL2
    SwitchGear 3'UTR luciferase reporter plasmidKIR3DL2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KIR3DL2 (see all 4)
    OriGene shRNA RFP: KIR3DL2
    OriGene siRNA: KIR3DL2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIR3DL2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KIR3DL2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIR3DL2 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIR3DL2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: KIR3DL2 (NM_006737)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KIR3DL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIR3DL2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KIR3DL2
    Search LifeMap BioReagents cell lines for KIR3DL2

    In Situ Assay
    Products:
       

     
    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for KIR3DL2

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity ----


    KIR3DL2 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Immune System
    Immune System1.00
    Adaptive Immune System0.59
    2Allograft rejection
    Graft-versus-host disease0.63
    Antigen processing and presentation0.25
    3Natural killer cell mediated cytotoxicity
    Natural killer cell mediated cytotoxicity1.00
    4Cleavage of Alpha-1-Microglobulin
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell0.30

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for KIR3DL2
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Adaptive Immune System
    Immune System


    3         Kegg Pathways  (Kegg details for KIR3DL2):
        Antigen processing and presentation
    Natural killer cell mediated cytotoxicity
    Graft-versus-host disease


    KIR3DL2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KIR3DL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/8 Interacting proteins for KIR3DL2 (P436303 ENSP000003255254) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HLA-AP304433, ENSP000003660054I2D: score=1 I2D: score=1 STRING: ENSP00000366005
    HLA-CENSP000003654024STRING: ENSP00000365402
    PTPN11ENSP000003409444STRING: ENSP00000340944
    PTPN6ENSP000003915924STRING: ENSP00000391592
    ENSG00000235657ENSP000003885264STRING: ENSP00000388526
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006968cellular defense response TAS7716543
    GO:0050776regulation of immune response TAS--


    KIR3DL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KIR3DL2
    Search CenterWatch for drugs/clinical trials and news about KIR3DL2 / KI3L2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KIR3DL2 gene (2 alternative transcripts): 
    NM_001242867.1  NM_006737.3  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000326321(uc002qho.4 uc010esh.3) ENST00000270442

    miRNA
    Products:
         
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KIR3DL2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate KIR3DL2
    SwitchGear 3'UTR luciferase reporter plasmidKIR3DL2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KIR3DL2 (see all 4)
    OriGene shRNA RFP: KIR3DL2
    OriGene siRNA: KIR3DL2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIR3DL2
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIR3DL2 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIR3DL2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: KIR3DL2 (NM_006737)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KIR3DL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIR3DL2 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIR3DL2
    Browse OriGene validated miRNA SYBR primer pairs
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat KIR3DL2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIR3DL2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIR3DL2

    5 AceView cDNA sequences:

    NM_153443 L41268 BI909683 NM_014218 NM_014511 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KIR3DL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See KIR3DL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KIR3DL2
        SABiosciences Custom PCR Arrays for KIR3DL2
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIR3DL2
    Browse OriGene validated miRNA SYBR primer pairs
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat KIR3DL2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIR3DL2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIR3DL2
    In Situ
    Assay Products:
     

     
    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for KIR3DL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for KIR3DL2 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    --
    (see all 59)
    --
    23(a)
    22(a)
    (see all 59)
    many ↔ many
    many ↔ many
    (see all 59)
    Un(51843257-51844123)
    Un(7502858-7503788)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    --
    19(a)
    16(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    GL343329.1(1231914-1234163)
    GL343329.1(823590-844642)


    ENSEMBL Gene Tree for KIR3DL2 (if available)
    TreeFam Gene Tree for KIR3DL2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KIR3DL2 gene
    KIR2DL42  LILRB42  LILRB12  LILRA62  IGSF12  LILRA52  KIR3DL12  OSCAR2  
    NCR12  LILRA42  ENSG000002177922  TARM12  KIR3DX12  LILRA32  LILRB52  KIR3DL32  
    LILRA12  KIR2DL12  LILRB22  A1BG2  KIR2DL22  LILRA22  KIR2DL32  FCAR2  
    LILRB32  GP62  
    18/53 SIMAP similar genes for KIR3DL2 using alignment to 46 protein entries:     KI3L2_HUMAN (see all proteins) (see all similar genes):
    p140    kir3d    KIR411    KIR-K39    KIR3DL1/2V    KIR3DL1
    KIR3DS1    KIR-123FM    KIR-K15    KIR2DL3    KIR221    KIR-G1
    KIR-K78    KIR-K36    KIR-K61    KIR-K65    KIR412    KIR2DL2

    KIR3DL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/422 NCBI SNPs in KIR3DL2 are shown (see all 422    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1405839281,2
    C,Fother55365482(+) GACCCC/TCTGGA 16 P syn11Minor allele frequency- T:0.02EU 923
    rs20047171,2
    C,F,A,H--55360538(-) TCATCT/CCTTGA 2 -- us2k110Minor allele frequency- C:0.19NS EA NA CSA 586
    rs1452566871,2
    C--55360594(+) TGCTA-/TTTT  
            
    TTTTT
    2 -- us2k10--------
    rs351893011,2
    C,F--55360675(+) ACCTCT/CGCCTC 8 -- us2k13Minor allele frequency- C:0.40NA CSA 5
    rs2012566161,2
    F--55362003(+) TGGGGA/TTGGAG 8 -- int11Minor allele frequency- T:0.00EU 785
    rs621233651,2
    C--55362406(+) CCTGGA/TGTGGA 2 -- int10--------
    rs72599881,2
    C,F,--55362416(+) AGATAG/TGGGCC 6 -- int14Minor allele frequency- T:0.50NA CSA 6
    rs1505402761,2
    --55362719(+) AGTCCG/TTCCCC 2 -- int10--------
    rs1833959621,2
    --55362880(+) TTCCTA/GAGTCA 2 -- int10--------
    rs1501537331,2
    --55363065(+) GGCTGC/TGGTCT 2 -- int10--------

    HapMap Linkage Disequilibrium report for KIR3DL2 (55361898 - 55378662 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 19 variations for KIR3DL2
         15/19 CNVs (see all 19): 50215 73430 50221 89325 8876 50223 50222 73425 0809 50226 73429 2248 4088 5117 30927
    Human Gene Mutation Database (HGMD): KIR3DL2

    Locus Specific Mutation Databases (LSDB): KIR3DL2

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIR3DL2
    DNA2.0 Custom Variant and Variant Library Synthesis for KIR3DL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    KIR3DL2 for disorders           About GeneDecksing

    OMIM gene information: 604947    OMIM disorders: --

    20/34 diseases for KIR3DL2 (see all 34):    About MalaCards
    vogt-koyanagi-harada disease    tropical spastic paraparesis    graft versus host disease    spastic paraparesis
    pre-eclampsia    familial mediterranean fever    non-hodgkin lymphoma    cervical intraepithelial neoplasia
    spontaneous abortion    ankylosing spondylitis    spasticity    calcinosis
    spondylitis    cutaneous t cell lymphoma    leptospirosis    behcet's disease
    eclampsia    hodgkin's lymphoma    multiple sclerosis    hepatitis c

    1 disease from the University of Copenhagen DISEASES database for KIR3DL2:
    Cutaneous T cell lymphoma

    1 Novoseek disease relationship for KIR3DL2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma 10.6 2 11337356 (2)

    Genetic Association Database (GAD): KIR3DL2
    Human Genome Epidemiology (HuGE) Navigator: KIR3DL2 (75 documents)

    Export disorders for KIR3DL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KIR3DL2 gene, integrated from 9 sources (see all 107):
    (articles sorted by number of sources associating them with KIR3DL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Alternatively spliced forms of human killer inhibitory receptors. (PubMed id 8662091)1, 2, 3 Dohring C....Colonna M. (1996)
    2. Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. (PubMed id 7716543)1, 2, 3 Colonna M. and Samaridis J. (1995)
    3. A population-based cohort study of KIR genes and genotypes in relation to cervical intraepithelial neoplasia. (PubMed id 15730517)1, 4 Arnheim L....Sanjeevi C.B. (2005)
    4. Distribution of killer cell immunoglobulin-like receptor genes in the Chinese Han population. (PubMed id 15896204)1, 4 Jiang K....Yan L.X. (2005)
    5. Investigation of killer cell immunoglobulin-like receptor gene diversity V. KIR3DL2. (PubMed id 15304002)1, 4 Meenagh A....Middleton D. (2004)
    6. Distinctive KIR and HLA diversity in a panel of north Indian Hindus. (PubMed id 11904677)1, 4 Rajalingam R....Parham P. (2002)
    7. Human diversity in killer cell inhibitory receptor genes. (PubMed id 9430221)1, 2 Uhrberg M.... Parham P. (1997)
    8. The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140-kD disulphide-linked dimer. (PubMed id 8760804)1, 2 Pende D.... Moretta L. (1996)
    9. Killer cell inhibitory receptors specific for HLA-C and HLA-B identified by direct binding and by functional transfer. (PubMed id 8777725)1, 2 Wagtmann N.... Long E.O. (1995)
    10. CD158k/KIR3DL2 is a useful marker for identifying neoplastic T-cells in Sezary syndrome by flow cytometry. (PubMed id 18061949)1, 9 Bahler D.W....Vonderheid E.C. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3812 HGNC: 6339 AceView: KIR2DL1 Ensembl:ENSG00000240403 euGenes: HUgn3812
    ECgene: KIR3DL2 Kegg: 3812 H-InvDB: KIR3DL2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KIR3DL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KIR3DL2 gene:
    Search GeneIP for patents involving KIR3DL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for KIR3DL2 (KIR3DL2/CD158k)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for KIR3DL2 (KIR3DL2/CD158k)  
     Browse OriGene Antibodies   OriGene shRNA RFP for KIR3DL2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KIR3DL2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIR3DL2  
     OriGene Protein Over-expression Lysate for KIR3DL2   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for KIR3DL2   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIR3DL2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIR3DL2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KIR3DL2   OriGene Custom Protein Services for KIR3DL2  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KIR3DL2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIR3DL2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIR3DL2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIR3DL2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIR3DL2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIR3DL2
     GenScript Custom Purified and Recombinant Proteins Services for KIR3DL2 GenScript cDNA clones with any tag delivered in your preferred vector for KIR3DL2
     GenScript Custom Assay Services for KIR3DL2 GenScript Custom Superior Antibodies Services for KIR3DL2
     GenScript Custom overexpressing Cell Line Services for KIR3DL2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in KIR3DL2 promoter
     Search Chromatin IP Primers for KIR3DL2
     RT2 qPCR Primer Assay in human, mouse / rat KIR3DL2
     GNC Network for KIR3DL2
     SABiosciences Custom PCR Arrays for KIR3DL2
     Search Tocris compounds for KIR3DL2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     KIR3DL2 lysates
     Search for Antibodies for KIR3DL2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for KIR3DL2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     KIR3DL2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for KIR3DL2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for KIR3DL2
     SwitchGear 3'UTR luciferase reporter plasmids for KIR3DL2
     SwitchGear Promoter luciferase reporter plasmids for KIR3DL2
     ThermoFisher Antibodies for KIR3DL2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIR3DL2
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KIR3DL2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4