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Aliases for KIR3DL2 Gene

Aliases for KIR3DL2 Gene

  • Killer Cell Immunoglobulin-Like Receptor, Three Domains, Long Cytoplasmic Tail, 2 2 3
  • NKAT4 3 4 6
  • P70 Natural Killer Cell Receptor Clone CL-5 3 4
  • Natural Killer-Associated Transcript 4 3 4
  • CD158 Antigen-Like Family Member K 3 4
  • MHC Class I NK Cell Receptor 3 4
  • P70 NK Receptor CL-5 3 4
  • CD158K 3 4
  • NKAT-4 3 4
  • Killer Cell Immunoglobulin-Like Receptor 3DL2 3
  • P70 Killer Cell Inhibitory Receptor 3
  • Killer Ig Receptor 3
  • KIR Antigen 3DL2 3
  • CD158k Antigen 4
  • NKAT4B 3
  • P140 3

External Ids for KIR3DL2 Gene

Previous GeneCards Identifiers for KIR3DL2 Gene

  • GC19U990058
  • GC19P055664
  • GC19P060005
  • GC19P060010
  • GC19P060053
  • GC19P059939
  • GC19P055361
  • GC19P051684

Summaries for KIR3DL2 Gene

Entrez Gene Summary for KIR3DL2 Gene

  • Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2011]

GeneCards Summary for KIR3DL2 Gene

KIR3DL2 (Killer Cell Immunoglobulin-Like Receptor, Three Domains, Long Cytoplasmic Tail, 2) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Immune response Role of DAP12 receptors in NK cells. An important paralog of this gene is KIR2DL4.

UniProtKB/Swiss-Prot for KIR3DL2 Gene

  • Receptor on natural killer (NK) cells for HLA-A alleles. Inhibits the activity of NK cells thus preventing cell lysis

Gene Wiki entry for KIR3DL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIR3DL2 Gene

Genomics for KIR3DL2 Gene

Regulatory Elements for KIR3DL2 Gene

Genomic Location for KIR3DL2 Gene

Start:
54,850,443 bp from pter
End:
54,867,215 bp from pter
Size:
16,773 bases
Orientation:
Plus strand

Genomic View for KIR3DL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIR3DL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for KIR3DL2 Gene

  • Protein details for KIR3DL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43630-KI3L2_HUMAN
    Recommended name:
    Killer cell immunoglobulin-like receptor 3DL2
    Protein Accession:
    P43630
    Secondary Accessions:
    • Q13238
    • Q14947
    • Q14948
    • Q92684
    • Q95366
    • Q95367
    • Q95368

    Protein attributes for KIR3DL2 Gene

    Size:
    455 amino acids
    Molecular mass:
    50230 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KIR3DL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIR3DL2 Gene

Proteomics data for KIR3DL2 Gene at MOPED

Post-translational modifications for KIR3DL2 Gene

  • Glycosylation at Asn179, Asn239, Asn273, and Asn306
  • Modification sites at PhosphoSitePlus

Other Protein References for KIR3DL2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KIR3DL2 Gene

Domains for KIR3DL2 Gene

Gene Families for KIR3DL2 Gene

HGNC:
  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • KIR :Killer cell immunoglobulin-like receptors

Protein Domains for KIR3DL2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for KIR3DL2 Gene

Graphical View of Domain Structure for InterPro Entry

P43630

UniProtKB/Swiss-Prot:

KI3L2_HUMAN :
  • P43630
Domain:
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Family:
  • Belongs to the immunoglobulin superfamily.
genes like me logo Genes that share domains with KIR3DL2: view

Function for KIR3DL2 Gene

Molecular function for KIR3DL2 Gene

GENATLAS Biochemistry: natural killer cell immunoglobulin-like inhibitory receptor for HLA-B antigens,3DL2,70kDa,with several alternatively spliced (truncated) forms
UniProtKB/Swiss-Prot Function: Receptor on natural killer (NK) cells for HLA-A alleles. Inhibits the activity of NK cells thus preventing cell lysis

miRNA for KIR3DL2 Gene

miRTarBase miRNAs that target KIR3DL2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for KIR3DL2 Gene

Localization for KIR3DL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIR3DL2 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIR3DL2 Gene COMPARTMENTS Subcellular localization image for KIR3DL2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
endoplasmic reticulum 1
endosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KIR3DL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7716543
genes like me logo Genes that share ontologies with KIR3DL2: view

Pathways for KIR3DL2 Gene

genes like me logo Genes that share pathways with KIR3DL2: view

Interacting Proteins for KIR3DL2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000325525%0d%0a9606.ENSP00000366005%0d%0a
Selected Interacting proteins: ENSP00000325525 P43630-KI3L2_HUMAN for KIR3DL2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for KIR3DL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006968 cellular defense response TAS 7716543
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with KIR3DL2: view

Transcripts for KIR3DL2 Gene

mRNA/cDNA for KIR3DL2 Gene

(36) REFSEQ mRNAs :
(5) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for KIR3DL2 Gene

No ASD Table

Relevant External Links for KIR3DL2 Gene

GeneLoc Exon Structure for
KIR3DL2
ECgene alternative splicing isoforms for
KIR3DL2

Expression for KIR3DL2 Gene

mRNA expression in normal human tissues for KIR3DL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIR3DL2 Gene

This gene is overexpressed in Whole Blood (42.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for KIR3DL2 Gene

genes like me logo Genes that share expressions with KIR3DL2: view

No data available for mRNA Expression by UniProt/SwissProt for KIR3DL2 Gene

Orthologs for KIR3DL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIR3DL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIR3DL5 35
  • 90.54 (n)
  • 83.56 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 30 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 32 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Kir3dl1 36
  • 42 (a)
ManyToMany
Kir3dl2 16
Kir3dl2 36
  • 41 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 28 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 21 (a)
ManyToMany
-- 36
  • 16 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 16 (a)
OneToMany
Species with no ortholog for KIR3DL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KIR3DL2 Gene

ENSEMBL:
Gene Tree for KIR3DL2 (if available)
TreeFam:
Gene Tree for KIR3DL2 (if available)

Paralogs for KIR3DL2 Gene

genes like me logo Genes that share paralogs with KIR3DL2: view

Variants for KIR3DL2 Gene

Sequence variations from dbSNP and Humsavar for KIR3DL2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs586955 -- 54,859,702(+) TCGTG(G/T)GTGAA intron-variant
rs590251 -- 54,861,606(+) ATCGC(A/G)TCACT intron-variant
rs592446 -- 54,854,144(+) GCGTG(A/G)GATTC intron-variant
rs600888 -- 54,860,473(+) TGAAC(G/T)GATCT intron-variant
rs601838 -- 54,860,712(+) TGTAT(G/T)ATTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIR3DL2 Gene

Variant ID Type Subtype PubMed ID
dgv1119e1 CNV Complex 17122850
esv2667609 CNV Deletion 23128226
esv2718872 CNV Deletion 23290073
dgv1126e1 CNV Complex 17122850
nsv428372 CNV Gain+Loss 18775914
nsv833879 CNV Gain+Loss 17160897
dgv1127e1 CNV Complex 17122850
dgv1128e1 CNV Complex 17122850
nsv469656 CNV Gain 16826518
nsv471706 CNV Loss 15918152
nsv437834 CNV Loss 16327808
dgv667e199 CNV Deletion 23128226
nsv517143 CNV Gain+Loss 19592680
dgv4007n71 CNV Gain+Loss 21882294
dgv4008n71 CNV Gain 21882294
esv26630 CNV Gain+Loss 19812545
dgv577e201 CNV Deletion 23290073
dgv144e55 CNV Gain 17911159
nsv912427 CNV Loss 21882294
esv2661467 CNV Deletion 23128226
nsv458810 CNV Loss 19166990
dgv438n27 CNV Gain 19166990
nsv912443 CNV Loss 21882294
esv2718931 CNV Deletion 23290073
esv32688 CNV Loss 17666407
esv2718932 CNV Deletion 23290073
nsv9765 CNV Gain 18304495

Relevant External Links for KIR3DL2 Gene

HapMap Linkage Disequilibrium report
KIR3DL2
Human Gene Mutation Database (HGMD)
KIR3DL2
Locus Specific Mutation Databases (LSDB)
KIR3DL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIR3DL2 Gene

Disorders for KIR3DL2 Gene

(1) University of Copenhagen DISEASES for KIR3DL2 Gene

(1) Novoseek inferred disease relationships for KIR3DL2 Gene

Disease -log(P) Hits PubMed IDs
lymphoma 10.6 2

Relevant External Links for KIR3DL2

Genetic Association Database (GAD)
KIR3DL2
Human Genome Epidemiology (HuGE) Navigator
KIR3DL2
genes like me logo Genes that share disorders with KIR3DL2: view

No data available for UniProtKB/Swiss-Prot for KIR3DL2 Gene

Publications for KIR3DL2 Gene

  1. Alternatively spliced forms of human killer inhibitory receptors. (PMID: 8662091) Doehring C. … Colonna M. (Immunogenetics 1996) 2 3 4
  2. [Allelic polymorphism analysis of killer cell immunoglobulin-like receptor gene 3DL2 in Zhejiang Han population]. (PMID: 16767680) Jiang K. … Yan L.X. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2006) 3 23 48
  3. [The study of killer cell immunoglobulin-like receptor 3DL2 gene polymorphisms and pre-eclampsia]. (PMID: 19953898) Wang X.L. … Sun C.J. (Zhonghua Yi Xue Za Zhi 2009) 3 23 48
  4. Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. (PMID: 7716543) Colonna M. … Samaridis J. (Science 1995) 2 3 4
  5. [Polymorphism of killer cell immunoglobulin-like receptor gene and its correlation with leukemia]. (PMID: 17490516) Chen A.M. … Liu Q.P. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2007) 3 48

Products for KIR3DL2 Gene

Sources for KIR3DL2 Gene

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