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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KIR3DL1 Gene

protein-coding   GIFtS: 63
GCID: GC19P055268

killer cell immunoglobulin-like receptor, three domains,...


(Previous symbol: KIR)
 Explore 76 diseases affiliated with
KIR3DL1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KIR3DL1    

Aliases
for KIR3DL1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Killer Cell Immunoglobulin-Like Receptor, Three Domains, Long Cytoplasmic
Tail, 11 2
     CD158e21
NKB11 2 3 5     Cl-111
NKAT32 3 5     Cl-21
KIR1 2     Nkat31
NKB1B1 2     CD158E12
Natural Killer-Associated Transcript 32 3     KIR3DL1/S12
NKAT-32 3     NK-Receptor1
CD158 Antigen-Like Family Member E2 3     Killer Cell Immunoglobulin-Like Receptor 3DL12
HLA-BW4-Specific Inhibitory NK Cell Receptor2 3     Killer Ig Receptor2
MHC Class I NK Cell Receptor2 3     KIR Antigen 3DL12
P70 Natural Killer Cell Receptor Clones CL-2/CL-112 3     P70 Killer Cell Inhibitory Receptor2
P70 NK Receptor CL-2/CL-112 3     CD158E3
AMB111 5     CD158e Antigen3
CD158e11     KIR3DS15
CD158e1/21     

External Ids:    HGNC: 63381   Entrez Gene: 38112   Ensembl: ENSG000001676337   OMIM: 6049465   UniProtKB: P436293   

Export aliases for KIR3DL1 gene to outside databases

Previous GC identifers: GC19P056190 GC19P055662 GC19P060003 GC19P060009 GC19P060019 GC19P059929 GC19P055327 GC19P051650 GC19P055253 GC19P055257 GC19P055262


Summaries
for KIR3DL1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KIR3DL1:
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and
subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome
19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among
haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The
KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have
a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals
upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short
cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to
transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR
proteins are thought to play an important role in regulation of the immune response. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KI3L1_HUMAN, P43629
Function: Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing
cell lysis

Gene Wiki entry for KIR3DL1


Genomic Views
for KIR3DL1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KIR3DL1 gene promoter:
         STAT1   STAT1beta   STAT5A   STAT1alpha   YY1   CREB   deltaCREB   STAT2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): KIR3DL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for KIR3DL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIR3DL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.4

KIR3DL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIR3DL1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P055268:  view genomic region     (about GC identifiers)

Start:
 55,235,969 bp from pter      End:
 55,378,448 bp from pter
Size:
 142,480 bases      Orientation:
 plus strand

Proteins
for KIR3DL1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KI3L1_HUMAN, P43629 (See protein sequence)
Recommended Name: Killer cell immunoglobulin-like receptor 3DL1 precursor  
Size: 444 amino acids; 49098 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein
1 PDB 3D structure from and Proteopedia for KIR3DL1:
3VH8 (3D)    
Secondary accessions: O43473 Q16541

Explore the universe of human proteins at neXtProt for KIR3DL1: NX_P43629

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P43629

    • KIR3DL1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_037421.2  
    ENSEMBL proteins: 
     ENSP00000375608   ENSP00000326868   ENSP00000350901   ENSP00000384528   ENSP00000443350  
     ENSP00000442355  
    Reactome Protein details: P43629
    Human Recombinant Protein Products: 
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    Novus Biologicals KIR3DL1 Proteins
    Novus Biologicals KIR3DL1 Lysate
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    ProSpec Recombinant Protein for KIR3DL1
    Uscn Proteins for KIR3DL1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane NAS7716543


    KIR3DL1 for ontologies           About GeneDecksing



    KIR3DL1 Antibody Products: 
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    Uscn ELISAs and CLIAs for KIR3DL1

    Protein Domains /
    Families
    for KIR3DL1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KIR3DL1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR013783 Ig-like_fold
     IPR003599 Ig_sub
     IPR013151 Immunoglobulin

    Graphical View of Domain Structure for InterPro Entry P43629

    ProtoNet protein and cluster: P43629

    1 Blocks protein family: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: KI3L1_HUMAN, P43629
    Similarity: Belongs to the immunoglobulin superfamily
    Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains


    Function
    for KIR3DL1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KI3L1_HUMAN, P43629
    Function: Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing
    cell lysis

         Genatlas biochemistry entry for KIR3DL1:
    natural killer cell immunoglobulin-like inhibitory receptor for HLA-B antigens,3DL1,70kDa,with several alternatively
    spliced (truncated) forms

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
    Products:       
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030109HLA-B specific inhibitory MHC class I receptor activity NAS7650366


    KIR3DL1 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for KIR3DL1:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Increased G1 DNA content 


    Pathways & Interactions
    for KIR3DL1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Immune System
    		Immune System1.00
    		Adaptive Immune System0.59
    2Allograft rejection
    		Graft-versus-host disease0.63
    		Antigen processing and presentation0.25
    3Immune response CD16 signaling in NK cells
    		Immune response Role of DAP12 receptors in NK cells0.32
    		Immune response_Role of DAP12 receptors in NK cells0.32
    4Validated targets of C-MYC transcriptional activation
    		Validated targets of C-MYC transcriptional activation1.00
    5Natural killer cell mediated cytotoxicity
    		Natural killer cell mediated cytotoxicity1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for KIR3DL1
        Immune response Role of DAP12 receptors in NK cells


    1 GeneGo (Thomson Reuters) Pathway for KIR3DL1
        Immune response Role of DAP12 receptors in NK cells

    1 BioSystems Pathway for KIR3DL1 
        Validated targets of C-MYC transcriptional activation

    3        Reactome Pathways for KIR3DL1
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Adaptive Immune System
    Immune System


    3         Kegg Pathways  (Kegg details for KIR3DL1):
        Antigen processing and presentation
    Natural killer cell mediated cytotoxicity
    Graft-versus-host disease


    KIR3DL1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KIR3DL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/13 Interacting proteins for KIR3DL1 (P436293 ENSP000003756084) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK3Q005263, ENSP000004000884I2D: score=1 STRING: ENSP00000400088
    HLA-BP018893, ENSP000003991684I2D: score=1 STRING: ENSP00000399168
    PTPN11Q061243, ENSP000003409444I2D: score=1 STRING: ENSP00000340944
    PTPN6P293503, ENSP000003915924I2D: score=1 STRING: ENSP00000391592
    HLA-GP176933I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response NAS7716543
    GO:0050776regulation of immune response TAS--


    KIR3DL1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for KIR3DL1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KIR3DL1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KIR3DL1
    10/15 Novoseek chemical compound relationships for KIR3DL1 gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 32 46 8986721 (3), 12794140 (3), 11513144 (3), 9236201 (2) (see all 22)
    5-aza-2'deoxycytidine 12.3 3 12538663 (1), 16237090 (1), 19922420 (1)
    oligonucleotide 9.03 4 17445176 (1), 12209364 (1), 12694580 (1), 11844144 (1)
    lipid 4.66 3 9751747 (1), 15265884 (1)
    potassium 3.73 1 10462549 (1)
    atp 1.81 1 15320752 (1)
    hydrogen 1.54 2 11256749 (1)
    isoleucine 0.94 4 12134147 (1), 17411378 (1), 17022732 (1)
    lysine 0 1 9293775 (1)
    phosphotyrosine 0 1 9079806 (1)

    Search CenterWatch for drugs/clinical trials and news about KIR3DL1 / KI3L1 

    Transcripts
    for KIR3DL1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KIR3DL1 gene: 
    NM_013289.2  

    Unigene Cluster for KIR3DL1:

    Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
    Hs.645228
    Unigene Representative Sequence: NM_013289
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000391728(uc021vbm.1 uc010esf.3 uc021vbo.1 uc002qhk.4)
    ENST00000326542 ENST00000358178 ENST00000402254(uc002qhl.4) ENST00000538269
    ENST00000541392

    miRNA
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    Inhib. RNA
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    OriGene shRNA RFP: KIR3DL1
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    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIR3DL1
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    Additional cDNA sequence: 

    AF022049.1 AF103010.1 AF103011.1 AF103012.1 AF103013.1 AF208688.1 AF208689.1 AF262968.1 
    AF262969.1 AF262970.1 AF262971.1 AF262972.1 AF262973.1 AF262974.1 AJ417556.1 AJ417557.1 
    AY059417.1 AY366236.1 AY366249.1 AY366250.1 AY366251.1 AY366252.1 AY366253.1 AY366254.1 
    AY366255.1 AY760050.1 AY789065.1 AY789066.1 AY789072.1 BC028206.1 BC101540.1 BC101542.1 
    BC105678.1 BC107951.1 DQ178659.1 EF462885.1 EF472674.1 EF472675.1 EF472676.1 EF472677.1 
    EF472678.1 EF472679.1 L41269.1 L76664.1 U30273.1 U30274.1 U31416.1 U33328.1 
    X94262.1 X97230.1 

    4 DOTS entries:

    DT.455734  DT.310897  DT.92058638  DT.95344541 

    24/93 AceView cDNA sequences (see all 93):

    AF034773 AY366242 AF285434 AF208054 AY052498 AY052497 AY223515 AF002979 
    BV180934 BM917014 AF002981 BV206441 AF034772 AY250088 X99480 X97232 
    X97229 AY366247 BV206442 AY223512 AF285436 AF272389 BI908736 BV199144 

    GeneLoc Exon Structure


    Expression
    for KIR3DL1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KIR3DL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCTGCCCTCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KIR3DL1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Natural killer-like cells (Derivation of hemato...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See KIR3DL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KIR3DL1

    SOURCE GeneReport for Unigene cluster: Hs.645228
        SABiosciences Custom PCR Arrays for KIR3DL1
    Primer
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    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for KIR3DL1

    Orthologs
    for KIR3DL1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for KIR3DL1 gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves --
    --
    (see all 59)    		 --
    		 25(a)
    23(a)
    (see all 59)    		 many ↔ many
    many ↔ many
    (see all 59)    		 Un(51843257-51844123)
    Un(7502858-7503788)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 3)    		 --
    		 20(a)
    17(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 GL343329.1(1231914-1234163)
    GL343329.1(823590-844642)


    ENSEMBL Gene Tree for KIR3DL1 (if available)
    TreeFam Gene Tree for KIR3DL1 (if available) 

    Paralogs
    for KIR3DL1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KIR3DL1 gene
    KIR2DL42  LILRB42  LILRB12  LILRA62  IGSF12  LILRA52  OSCAR2  NCR12  
    LILRA42  ENSG000002177922  TARM12  KIR3DX12  LILRA32  LILRB52  LILRA12  KIR3DL32  
    KIR2DL12  LILRB22  A1BG2  KIR2DL22  LILRA22  KIR3DL22  KIR2DL32  FCAR2  
    LILRB32  GP62  
    18/55 SIMAP similar genes for KIR3DL1 using alignment to 61 protein entries:     KI3L1_HUMAN (see all proteins) (see all similar genes):
    KIR3DL1/2V    KIR-123FM    KIR3DS1    KIR-G1    KIR411    KIR3DL2
    KIR221    kir3d    KIR-K39    KIR2DL3    KIR-K15    KIR-K36
    p140    KIR2DL2    KIR2DL1    KIR2DS2    KIR2DS4    KIR2DS1

    KIR3DL1 for paralogs           About GeneDecksing



    Genomic Variants
    for KIR3DL1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/583 NCBI SNPs in KIR3DL1 are shown (see all 583)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1445179261,2
    		--55306322(+) CATTCA/TGTGGG 1 -- int10--------
    rs1399641721,2
    		--55307344(+) TCCTCA/TTTTCT 1 -- int10--------
    rs1833476961,2
    		--55307378(+) GTTGCA/CCAATA 1 -- int10--------
    rs1419254181,2
    		C--55309840(+) AAACT-/ACACACA 1 -- int10--------
    rs561661471,2
    		C,--55309886(-) ATGAAC/ACAATC 1 -- int13Minor allele frequency- A:0.08NA 12
    rs6788121,2
    		C,F,H--55326594(+) CCTGAA/GACCAA 1 -- int1 tfbs36Minor allele frequency- G:0.17NS EA NA 492
    rs6788461,2
    		C,F,H--55326613(+) GAATAG/ATGAGG 1 -- int17Minor allele frequency- A:0.17NS EA NA 684
    rs1909734281,2
    		C--55327686(+) CATCTC/TGTGTT 1 -- int10--------
    rs1504422081,2
    		--55327687(+) ATCTCA/GTGTTC 1 -- int10--------
    rs1502705841,2
    		C--55327960(+) CATGTC/TGCTCA 2 S L mis10--------

    HapMap Linkage Disequilibrium report for KIR3DL1 (55235969 - 55378448 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 24 variations for KIR3DL1
         15/24 CNVs (see all 24): 50215 73430 50221 89325 8876 67612 50223 50222 73425 0809 50226 2248 102880 4088 5117
    Human Gene Mutation Database (HGMD): KIR3DL1

    Locus Specific Mutation Databases (LSDB): KIR3DL1

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for KIR3DL1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KIR3DL1 for disorders           About GeneDecksing

    OMIM gene information: 604946   
    OMIM disorders: 609423  
    20/76 diseases for KIR3DL1 (see all 76):    About MalaCards
    aids, delayed/rapid progression to    vogt-koyanagi-harada disease    graft versus host disease    birdshot chorioretinopathy
    acute graft versus host disease    tropical spastic paraparesis    age related macular degeneration    microscopic polyangiitis
    sclerosing cholangitis    spastic paraparesis    primary sclerosing cholangitis    pre-eclampsia
    familial mediterranean fever    non-hodgkin lymphoma    cervical intraepithelial neoplasia    juvenile myelomonocytic leukemia
    type 1 diabetes mellitus    anterior uveitis    macular degeneration    beta thalassemia

    10/37 Novoseek disease relationships for KIR3DL1 gene (see all 37)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    graft-versus-host disease 57.2 8 16864058 (1), 16399580 (1), 17445182 (1), 15157342 (1) (see all 8)
    acute graft-versus-host disease 55.2 2 16131567 (1), 15935882 (1)
    hematologic malignancies 51.2 17 18269867 (2), 19857587 (1), 19961944 (1), 16864053 (1) (see all 8)
    tumor escape 45.5 1 12472656 (1)
    leukemia 41.6 42 17490516 (3), 17060849 (2), 19664139 (2), 17445161 (2) (see all 22)
    myeloid leukemia 35.5 3 14504099 (2), 15536148 (1), 17708809 (1)
    virus infection 34.8 10 15809348 (1), 16084708 (1), 19118512 (1), 16571411 (1) (see all 10)
    autoimmune diseases 31.4 6 15719024 (1), 16263420 (1), 18976447 (1), 16123537 (1) (see all 5)
    autoimmunity 31.1 5 15809348 (1), 20035856 (1), 17445178 (1), 17464504 (1) (see all 5)
    myeloid leukemia chronic 27.9 4 17339492 (1), 15731175 (1), 18718052 (1)

    Genetic Association Database (GAD): KIR3DL1
    Human Genome Epidemiology (HuGE) Navigator: KIR3DL1 (109 documents)

    Export disorders for KIR3DL1 gene to outside databases

    Publications
    for KIR3DL1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KIR3DL1 gene, integrated from 9 sources (see all 468):
    (articles sorted by number of sources associating them with KIR3DL1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. (PubMed id 7716543)1, 2, 3 Colonna M. and Samaridis J. (1995)
    2. Human diversity in killer cell inhibitory receptor genes. (PubMed id 9430221)1, 2, 9 Uhrberg M.... Parham P. (1997)
    3. Interaction between KIR3DL1 and HLA-B*57 supertype alleles influences the progression of HIV-1 infection in a Zambian population. (PubMed id 15784466)1, 4, 9 Lopez-Vazquez A....Lopez-Larrea C. (2005)
    4. Protective effect of the HLA-Bw4I80 epitope and the killer cell immunoglobulin-like receptor 3DS1 gene against the development of hepatocellular carcinoma in patients with hepatitis C virus infection. (PubMed id 15942906)1, 4, 9 Lopez-Vazquez A....Lopez-Larrea C. (2005)
    5. A population-based cohort study of KIR genes and genotypes in relation to cervical intraepithelial neoplasia. (PubMed id 15730517)1, 4, 9 Arnheim L....Sanjeevi C.B. (2005)
    6. Distribution of killer cell immunoglobulin-like receptor genes in the Chinese Han population. (PubMed id 15896204)1, 4 Jiang K....Yan L.X. (2005)
    7. Distinctive KIR and HLA diversity in a panel of north Indian Hindus. (PubMed id 11904677)1, 4 Rajalingam R....Parham P. (2002)
    8. The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140-kD disulphide-linked dimer. (PubMed id 8760804)1, 2 Pende D.... Moretta L. (1996)
    9. Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains. (PubMed id 7749980)1, 3 Wagtmann N....Long E.O. (1995)
    10. Molecular cloning of NKB1. A natural killer cell receptor for HLA-B allotypes. (PubMed id 7650366)1, 2 D'Andrea A....Lanier L.L. (1995)

    External Searches for KIR3DL1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing KIR3DL1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3811 HGNC: 6338 AceView: KIR2DL4 Ensembl:ENSG00000167633 euGenes: HUgn3811
    ECgene: KIR3DL1 Kegg: 3811 H-InvDB: KIR3DL1

    Other Databases showing KIR3DL1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KIR3DL1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KIR3DL1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KIR3DL1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for KIR3DL1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KIR3DL1 gene:
    Search GeneIP for patents involving KIR3DL1

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