Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KIR3DL1 Gene

Aliases for KIR3DL1 Gene

  • Killer Cell Immunoglobulin-Like Receptor, Three Domains, Long Cytoplasmic Tail, 1 2 3
  • NKAT3 3 4 6
  • NKB1 3 4 6
  • P70 Natural Killer Cell Receptor Clones CL-2/CL-11 3 4
  • HLA-BW4-Specific Inhibitory NK Cell Receptor 3 4
  • Natural Killer-Associated Transcript 3 3 4
  • CD158 Antigen-Like Family Member E 3 4
  • MHC Class I NK Cell Receptor 3 4
  • P70 NK Receptor CL-2/CL-11 3 4
  • NKAT-3 3 4
  • Killer Cell Immunoglobulin-Like Receptor 3DL1 3
  • P70 Killer Cell Inhibitory Receptor 3
  • Killer Ig Receptor 3
  • KIR Antigen 3DL1 3
  • CD158e Antigen 4
  • NK-Receptor 3
  • KIR3DL1/S1 3
  • CD158E1 3
  • KIR3DS1 6
  • CD158E 4
  • NKB1B 3
  • AMB11 6
  • KIR 3

External Ids for KIR3DL1 Gene

Previous HGNC Symbols for KIR3DL1 Gene

  • KIR

Previous GeneCards Identifiers for KIR3DL1 Gene

  • GC19P056190
  • GC19P055662
  • GC19P060003
  • GC19P060009
  • GC19P060019
  • GC19P059929
  • GC19P055327
  • GC19P051650
  • GC19P055253
  • GC19P055257
  • GC19P055262
  • GC19P055268
  • GC19P055274
  • GC19P055278

Summaries for KIR3DL1 Gene

Entrez Gene Summary for KIR3DL1 Gene

  • Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]

GeneCards Summary for KIR3DL1 Gene

KIR3DL1 (Killer Cell Immunoglobulin-Like Receptor, Three Domains, Long Cytoplasmic Tail, 1) is a Protein Coding gene. Diseases associated with KIR3DL1 include hiv-1 and birdshot chorioretinopathy. Among its related pathways are Signaling by FGFR and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include HLA-B specific inhibitory MHC class I receptor activity. An important paralog of this gene is KIR2DL4.

UniProtKB/Swiss-Prot for KIR3DL1 Gene

  • Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis.

Gene Wiki entry for KIR3DL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIR3DL1 Gene

Genomics for KIR3DL1 Gene

Regulatory Elements for KIR3DL1 Gene

Genomic Location for KIR3DL1 Gene

54,724,497 bp from pter
54,867,215 bp from pter
142,719 bases
Plus strand

Genomic View for KIR3DL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIR3DL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for KIR3DL1 Gene

  • Protein details for KIR3DL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Killer cell immunoglobulin-like receptor 3DL1
    Protein Accession:
    Secondary Accessions:
    • O43473
    • Q14946
    • Q16541

    Protein attributes for KIR3DL1 Gene

    444 amino acids
    Molecular mass:
    49098 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for KIR3DL1 Gene

    Alternative splice isoforms for KIR3DL1 Gene


neXtProt entry for KIR3DL1 Gene

Proteomics data for KIR3DL1 Gene at MOPED

Post-translational modifications for KIR3DL1 Gene

  • Glycosylation at Asn92, Asn179, and Asn273
  • Modification sites at PhosphoSitePlus

Other Protein References for KIR3DL1 Gene

Antibody Products

No data available for DME Specific Peptides for KIR3DL1 Gene

Domains for KIR3DL1 Gene

Gene Families for KIR3DL1 Gene

  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • KIR :Killer cell immunoglobulin-like receptors

Protein Domains for KIR3DL1 Gene

Suggested Antigen Peptide Sequences for KIR3DL1 Gene

Graphical View of Domain Structure for InterPro Entry



  • P43629
  • Ig-like C2-type domain 2 mediates specificity through recognition of the Bw4 epitope.
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily.
genes like me logo Genes that share domains with KIR3DL1: view

Function for KIR3DL1 Gene

Molecular function for KIR3DL1 Gene

GENATLAS Biochemistry: natural killer cell immunoglobulin-like inhibitory receptor for HLA-B antigens,3DL1,70kDa,with several alternatively spliced (truncated) forms
UniProtKB/Swiss-Prot Function: Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis.

Gene Ontology (GO) - Molecular Function for KIR3DL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030109 HLA-B specific inhibitory MHC class I receptor activity NAS 7650366
genes like me logo Genes that share ontologies with KIR3DL1: view
genes like me logo Genes that share phenotypes with KIR3DL1: view

Animal Model Products

CRISPR Products

miRNA for KIR3DL1 Gene

miRTarBase miRNAs that target KIR3DL1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIR3DL1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KIR3DL1 Gene

Localization for KIR3DL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIR3DL1 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for KIR3DL1 Gene COMPARTMENTS Subcellular localization image for KIR3DL1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KIR3DL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 7716543
genes like me logo Genes that share ontologies with KIR3DL1: view

Pathways for KIR3DL1 Gene

genes like me logo Genes that share pathways with KIR3DL1: view

Interacting Proteins for KIR3DL1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000375608 P43629-KI3L1_HUMAN for KIR3DL1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for KIR3DL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response NAS 7716543
GO:0007165 signal transduction NAS 7650366
GO:0042267 natural killer cell mediated cytotoxicity IMP 18502829
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with KIR3DL1: view

Compounds for KIR3DL1 Gene

(15) Novoseek inferred chemical compound relationships for KIR3DL1 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 32 30
5-aza-2deoxycytidine 12.3 3
oligonucleotide 9.03 4
lipid 4.66 2
potassium 3.73 1
genes like me logo Genes that share compounds with KIR3DL1: view

Transcripts for KIR3DL1 Gene

Unigene Clusters for KIR3DL1 Gene

Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIR3DL1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIR3DL1 Gene

No ASD Table

Relevant External Links for KIR3DL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KIR3DL1 Gene

mRNA expression in normal human tissues for KIR3DL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIR3DL1 Gene

This gene is overexpressed in Whole Blood (44.0).

SOURCE GeneReport for Unigene cluster for KIR3DL1 Gene Hs.645228

genes like me logo Genes that share expressions with KIR3DL1: view

In Situ Assay Products

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for KIR3DL1 Gene

Orthologs for KIR3DL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIR3DL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KIR3DL1 35
  • 95.7 (n)
  • 90.95 (a)
(Bos Taurus)
Mammalia -- 36
  • 31 (a)
(Canis familiaris)
Mammalia -- 36
  • 31 (a)
(Mus musculus)
Mammalia Kir3dl1 36
  • 42 (a)
Kir3dl2 36
  • 42 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 28 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 21 (a)
-- 36
  • 15 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 17 (a)
Species with no ortholog for KIR3DL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KIR3DL1 Gene

Gene Tree for KIR3DL1 (if available)
Gene Tree for KIR3DL1 (if available)

Paralogs for KIR3DL1 Gene

genes like me logo Genes that share paralogs with KIR3DL1: view

Variants for KIR3DL1 Gene

Sequence variations from dbSNP and Humsavar for KIR3DL1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs150789261 -- 54,830,047(+) GAGCA(A/C)CCTCC intron-variant
rs182558245 -- 54,824,685(+) ACACA(A/C)AAAAA intron-variant
rs199654642 -- 54,824,685(+) ACACA(-/C)AAAAA intron-variant
rs200630133 -- 54,825,431(+) GGGCG(-/A)GGTGT intron-variant
rs201299463 -- 54,826,984(+) TAATA(-/G)TGACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIR3DL1 Gene

Variant ID Type Subtype PubMed ID
dgv1119e1 CNV Complex 17122850
esv2667609 CNV Deletion 23128226
esv2718872 CNV Deletion 23290073
dgv1126e1 CNV Complex 17122850
nsv428372 CNV Gain+Loss 18775914
nsv833879 CNV Gain+Loss 17160897
dgv1127e1 CNV Complex 17122850
dgv1128e1 CNV Complex 17122850
nsv469656 CNV Gain 16826518
nsv471706 CNV Loss 15918152
nsv437834 CNV Loss 16327808
dgv667e199 CNV Deletion 23128226
nsv517143 CNV Gain+Loss 19592680
dgv4007n71 CNV Gain+Loss 21882294
dgv4008n71 CNV Gain 21882294
dgv575e201 CNV Deletion 23290073
esv26630 CNV Gain+Loss 19812545
nsv9761 CNV Gain+Loss 18304495
dgv577e201 CNV Deletion 23290073
esv32828 CNV Loss 17666407
dgv1129e1 CNV Complex 17122850
dgv144e55 CNV Gain 17911159
nsv912427 CNV Loss 21882294
dgv145e55 CNV Loss 17911159
esv2421952 CNV Deletion 20811451
dgv4009n71 CNV Loss 21882294
dgv4010n71 CNV Gain 21882294
nsv514902 CNV Complex 21397061
dgv1130e1 CNV Complex 17122850
dgv668e199 CNV Deletion 23128226
esv2661467 CNV Deletion 23128226
esv2718928 CNV Deletion 23290073
dgv4011n71 CNV Loss 21882294
dgv4012n71 CNV Gain 21882294
dgv4013n71 CNV Gain 21882294
nsv458810 CNV Loss 19166990
dgv438n27 CNV Gain 19166990
nsv912441 CNV Gain+Loss 21882294
nsv912443 CNV Loss 21882294
esv2718930 CNV Deletion 23290073
esv2718931 CNV Deletion 23290073
nsv9762 CNV Gain 18304495
esv7080 CNV Loss 19470904
esv2477686 CNV Loss 19546169

Relevant External Links for KIR3DL1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIR3DL1 Gene

Disorders for KIR3DL1 Gene

(1) OMIM Diseases for KIR3DL1 Gene (604946)

(1) University of Copenhagen DISEASES for KIR3DL1 Gene

(37) Novoseek inferred disease relationships for KIR3DL1 Gene

Disease -log(P) Hits PubMed IDs
graft-versus-host disease 57.2 8
acute graft-versus-host disease 55.2 2
hematologic malignancies 51.2 9
tumor escape 45.5 1
leukemia 41.6 27

Relevant External Links for KIR3DL1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with KIR3DL1: view

No data available for UniProtKB/Swiss-Prot for KIR3DL1 Gene

Publications for KIR3DL1 Gene

  1. Human diversity in killer cell inhibitory receptor genes. (PMID: 9430221) Uhrberg M. … Parham P. (Immunity 1997) 3 4 23
  2. Interaction between KIR3DL1 and HLA-B*57 supertype alleles influences the progression of HIV-1 infection in a Zambian population. (PMID: 15784466) LA^pez-VA!zquez A. … LA^pez-Larrea C. (Hum. Immunol. 2005) 3 23 48
  3. Protective effect of the HLA-Bw4I80 epitope and the killer cell immunoglobulin-like receptor 3DS1 gene against the development of hepatocellular carcinoma in patients with hepatitis C virus infection. (PMID: 15942906) LA^pez-VA!zquez A. … LA^pez-Larrea C. (J. Infect. Dis. 2005) 3 23 48
  4. Association of killer cell immunoglobulin-like receptor genotypes with microscopic polyangiitis. (PMID: 16508981) Miyashita R. … Tokunaga K. (Arthritis Rheum. 2006) 3 23 48
  5. KIR haplotype content at the allele level in 77 Northern Irish families. (PMID: 17200871) Middleton D. … Gourraud P.A. (Immunogenetics 2007) 3 23 48

Products for KIR3DL1 Gene

  • antibodies-online proteins for KIR3DL1
  • antibodies-online antibodies for KIR3DL1
  • antibodies-online kits for KIR3DL1

Sources for KIR3DL1 Gene

Back to Top