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Aliases for KIR3DL1 Gene

Aliases for KIR3DL1 Gene

  • Killer Cell Immunoglobulin Like Receptor, Three Ig Domains And Long Cytoplasmic Tail 1 2 3
  • Killer Cell Immunoglobulin-Like Receptor, Three Domains, Long Cytoplasmic Tail, 1 2 3 5
  • P70 Natural Killer Cell Receptor Clones CL-2/CL-11 3 4
  • HLA-BW4-Specific Inhibitory NK Cell Receptor 3 4
  • Natural Killer-Associated Transcript 3 3 4
  • CD158 Antigen-Like Family Member E 3 4
  • MHC Class I NK Cell Receptor 3 4
  • P70 NK Receptor CL-2/CL-11 3 4
  • NKAT-3 3 4
  • NKAT3 3 4
  • NKB1 3 4
  • Killer Cell Immunoglobulin-Like Receptor Three Domains Short Cytoplasmic Tail 1 3
  • Killer Cell Immunoglobulin-Like Receptor Three Domains Long Cytoplasmic Tail 2 3
  • P70 Killer Cell Inhibitory Receptor 3
  • Killer Ig Receptor 3
  • KIR Antigen 3DL1 3
  • CD158e Antigen 4
  • NK-Receptor 3
  • KIR3DL1/S1 3
  • CD158E1 3
  • KIR3DL2 3
  • CD158E 4
  • NKB1B 3
  • KIR 3

External Ids for KIR3DL1 Gene

Previous HGNC Symbols for KIR3DL1 Gene

  • KIR

Previous GeneCards Identifiers for KIR3DL1 Gene

  • GC19P056190
  • GC19P055662
  • GC19P060003
  • GC19P060009
  • GC19P060019
  • GC19P059929
  • GC19P055327
  • GC19P051650
  • GC19P055253
  • GC19P055257
  • GC19P055262
  • GC19P055268
  • GC19P055274
  • GC19P055278
  • GC19P054879
  • GC19P054911

Summaries for KIR3DL1 Gene

Entrez Gene Summary for KIR3DL1 Gene

  • Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]

GeneCards Summary for KIR3DL1 Gene

KIR3DL1 (Killer Cell Immunoglobulin Like Receptor, Three Ig Domains And Long Cytoplasmic Tail 1) is a Protein Coding gene. Diseases associated with KIR3DL1 include hiv-1 and hematopoietic stem cell transplantation. Among its related pathways are Immune System and Validated targets of C-MYC transcriptional activation. GO annotations related to this gene include HLA-B specific inhibitory MHC class I receptor activity. An important paralog of this gene is KIR2DL4.

UniProtKB/Swiss-Prot for KIR3DL1 Gene

  • Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis.

Gene Wiki entry for KIR3DL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIR3DL1 Gene

Genomics for KIR3DL1 Gene

Regulatory Elements for KIR3DL1 Gene

Genomic Location for KIR3DL1 Gene

54,816,438 bp from pter
54,866,993 bp from pter
50,556 bases
Plus strand

Genomic View for KIR3DL1 Gene

Genes around KIR3DL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIR3DL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIR3DL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for KIR3DL1 Gene

  • Protein details for KIR3DL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Killer cell immunoglobulin-like receptor 3DL1
    Protein Accession:
    Secondary Accessions:
    • O43473
    • Q14946
    • Q16541

    Protein attributes for KIR3DL1 Gene

    444 amino acids
    Molecular mass:
    49098 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for KIR3DL1 Gene

    Alternative splice isoforms for KIR3DL1 Gene


neXtProt entry for KIR3DL1 Gene

Proteomics data for KIR3DL1 Gene at MOPED

Post-translational modifications for KIR3DL1 Gene

  • Glycosylation at Asn 92, Asn 179, and Asn 273
  • Modification sites at PhosphoSitePlus

Other Protein References for KIR3DL1 Gene

Antibody Products

No data available for DME Specific Peptides for KIR3DL1 Gene

Domains & Families for KIR3DL1 Gene

Protein Domains for KIR3DL1 Gene

Suggested Antigen Peptide Sequences for KIR3DL1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Ig-like C2-type domain 2 mediates specificity through recognition of the Bw4 epitope.
  • Belongs to the immunoglobulin superfamily.
  • Ig-like C2-type domain 2 mediates specificity through recognition of the Bw4 epitope.
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily.
genes like me logo Genes that share domains with KIR3DL1: view

Function for KIR3DL1 Gene

Molecular function for KIR3DL1 Gene

GENATLAS Biochemistry:
natural killer cell immunoglobulin-like inhibitory receptor for HLA-B antigens,3DL1,70kDa,with several alternatively spliced (truncated) forms
UniProtKB/Swiss-Prot Function:
Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis.
genes like me logo Genes that share phenotypes with KIR3DL1: view

Animal Model Products

CRISPR Products

miRNA for KIR3DL1 Gene

miRTarBase miRNAs that target KIR3DL1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIR3DL1 Gene

Localization for KIR3DL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIR3DL1 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for KIR3DL1 Gene COMPARTMENTS Subcellular localization image for KIR3DL1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2
cytosol 1
extracellular 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for KIR3DL1 Gene

Pathways & Interactions for KIR3DL1 Gene

genes like me logo Genes that share pathways with KIR3DL1: view

Interacting Proteins for KIR3DL1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: P43629-KI3L1_HUMAN ENSP00000375608 for KIR3DL1 Gene via I2D STRING

SIGNOR curated interactions for KIR3DL1 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for KIR3DL1 Gene


Drugs & Compounds for KIR3DL1 Gene

(10) Drugs for KIR3DL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for KIR3DL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KIR3DL1: view

Transcripts for KIR3DL1 Gene

Unigene Clusters for KIR3DL1 Gene

Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIR3DL1 Gene

No ASD Table

Relevant External Links for KIR3DL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KIR3DL1 Gene

mRNA expression in normal human tissues for KIR3DL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIR3DL1 Gene

This gene is overexpressed in Whole Blood (x44.0).

SOURCE GeneReport for Unigene cluster for KIR3DL1 Gene Hs.645228

genes like me logo Genes that share expression patterns with KIR3DL1: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for KIR3DL1 Gene

Orthologs for KIR3DL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIR3DL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KIR3DL1 35
  • 95.7 (n)
  • 90.95 (a)
(Bos Taurus)
Mammalia -- 36
  • 31 (a)
(Canis familiaris)
Mammalia -- 36
  • 31 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 28 (a)
(Mus musculus)
Mammalia Kir3dl1 36
  • 42 (a)
Kir3dl2 36
  • 42 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 21 (a)
-- 36
  • 15 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 17 (a)
Species with no ortholog for KIR3DL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KIR3DL1 Gene

Gene Tree for KIR3DL1 (if available)
Gene Tree for KIR3DL1 (if available)

Paralogs for KIR3DL1 Gene

genes like me logo Genes that share paralogs with KIR3DL1: view

Variants for KIR3DL1 Gene

Sequence variations from dbSNP and Humsavar for KIR3DL1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_010319 -
VAR_010320 -
VAR_010321 -
VAR_010322 -
VAR_010323 -

Structural Variations from Database of Genomic Variants (DGV) for KIR3DL1 Gene

Variant ID Type Subtype PubMed ID
dgv1119e1 CNV Complex 17122850
esv2667609 CNV Deletion 23128226
esv2718872 CNV Deletion 23290073
dgv1126e1 CNV Complex 17122850
nsv428372 CNV Gain+Loss 18775914
nsv833879 CNV Gain+Loss 17160897
dgv1127e1 CNV Complex 17122850
dgv1128e1 CNV Complex 17122850
nsv469656 CNV Gain 16826518
nsv471706 CNV Loss 15918152
nsv437834 CNV Loss 16327808
dgv667e199 CNV Deletion 23128226
nsv517143 CNV Gain+Loss 19592680
dgv4007n71 CNV Gain+Loss 21882294
dgv4008n71 CNV Gain 21882294
dgv575e201 CNV Deletion 23290073
esv26630 CNV Gain+Loss 19812545
nsv9761 CNV Gain+Loss 18304495
dgv577e201 CNV Deletion 23290073
esv32828 CNV Loss 17666407
dgv1129e1 CNV Complex 17122850
dgv144e55 CNV Gain 17911159
nsv912427 CNV Loss 21882294
dgv145e55 CNV Loss 17911159
esv2421952 CNV Deletion 20811451
dgv4009n71 CNV Loss 21882294
dgv4010n71 CNV Gain 21882294
nsv514902 CNV Complex 21397061
dgv1130e1 CNV Complex 17122850
dgv668e199 CNV Deletion 23128226
esv2661467 CNV Deletion 23128226
esv2718928 CNV Deletion 23290073
dgv4011n71 CNV Loss 21882294
dgv4012n71 CNV Gain 21882294
dgv4013n71 CNV Gain 21882294
nsv458810 CNV Loss 19166990
dgv438n27 CNV Gain 19166990
nsv912441 CNV Gain+Loss 21882294
nsv912443 CNV Loss 21882294
esv2718930 CNV Deletion 23290073
esv2718931 CNV Deletion 23290073
nsv9762 CNV Gain 18304495
esv7080 CNV Loss 19470904
esv2477686 CNV Loss 19546169

Variation tolerance for KIR3DL1 Gene

Residual Variation Intolerance Score: 99.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.95; 87.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIR3DL1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIR3DL1 Gene

Disorders for KIR3DL1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for KIR3DL1 Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • aids, slow progression to
hematopoietic stem cell transplantation
birdshot chorioretinopathy
  • birdshot chorioretinitis
graft-versus-host disease, protection against
  • graft versus host disease
behcet's disease
  • adamantiades-behcet disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for KIR3DL1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with KIR3DL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIR3DL1 Gene

Publications for KIR3DL1 Gene

  1. Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. (PMID: 7716543) Colonna M. … Samaridis J. (Science 1995) 2 3 4 67
  2. The extensive polymorphism of KIR genes. (PMID: 20028428) Middleton D. … Gonzelez F. (Immunology 2010) 3 23
  3. Killer cell immunoglobulin-like receptor gene diversity in a Caucasian population of southern Brazil. (PMID: 20082646) Jobim M. … Schwartsmann G. (Int. J. Immunogenet. 2010) 3 23
  4. HLA and KIR frequencies in Sicilian Centenarians. (PMID: 20426625) ListA- F. … Candore G. (Rejuvenation Res 2010) 3 23
  5. Analysis of killer immunoglobulin-like receptor genes in ankylosing spondylitis. (PMID: 19019897) Harvey D. … Wordsworth B.P. (Ann. Rheum. Dis. 2009) 3 23

Products for KIR3DL1 Gene

Sources for KIR3DL1 Gene

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