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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KIR2DS5 Gene

protein-coding   GIFtS: 45
GCID: GC19P9Q0462

Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short
Cytoplasmic Tail, 51 2
     CD158 Antigen-Like Family Member G2 3
Natural Killer-Associated Transcript 92 3     MHC Class I NK Cell Receptor2 3
CD158G2 3     Killer Cell Immunoglobulin-Like Receptor 2DS52
NKAT-92 3     Natural Killer Cell Inhibitory Receptor2
NKAT92 3     CD158g Antigen3

External Ids:    HGNC: 63371   Entrez Gene: 38102   OMIM: 6049565   UniProtKB: Q149533   

Export aliases for KIR2DS5 gene to outside databases

Previous GC identifers: GC19U990056 GC19P9D0098 GC19P9F0100 GC00P9Q0099 GC19P9H0011 GC19P9H0091 GC19P059937 GC19P9I0098 GC19P9I0022 GC19P055236 GC19P9I0009


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KIR2DS5 Gene:
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells
and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on
chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster
varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1,
KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or
3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic
domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM),
while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO
protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are
subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the
immune response. (provided by RefSeq, Jul 2008)

GeneCards Summary for KIR2DS5 Gene: 
KIR2DS5 (killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5) is a protein-coding gene. Diseases associated with KIR2DS5 include leptospirosis, and hematopoietic stem cell transplantation, and among its related super-pathways are Immune System and DAP12 signaling. GO annotations related to this gene include HLA-C specific inhibitory MHC class I receptor activity. An important paralog of this gene is KIR2DS1.

UniProtKB/Swiss-Prot: KI2S5_HUMAN, Q14953
Function: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:NT_113949.1  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for KIR2DS5
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIR2DS5


Genomic Location:
Chromosome:19   

Entrez Gene cytogenetic band: 19q13.4   HGNC cytogenetic band: 19q13.4 GRCh37 novel patch

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P9Q0462:       (about GC identifiers)

Start:
462,346 bp from start of contig NW_003571055      End:
477,267 bp from start of contig NW_003571055
Size:
14,922 bases      Orientation:
plus strand

1 alternative location:
Chr19+,NT_113949 98,112-113,132     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KI2S5_HUMAN, Q14953 (See protein sequence)
Recommended Name: Killer cell immunoglobulin-like receptor 2DS5 precursor  
Size: 304 amino acids; 33644 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein

Explore the universe of human proteins at neXtProt for KIR2DS5: NX_Q14953

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14953

  • KIR2DS5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_055328.2  Reactome Protein details: Q14953
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane NAS8662091

    KIR2DS5 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    KIR: Killer cell immunoglobulin-like receptors
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    3 InterPro protein domains:
     IPR003599 Ig_sub
     IPR013783 Ig-like_fold
     IPR013151 Immunoglobulin

    Graphical View of Domain Structure for InterPro Entry Q14953

    ProtoNet protein and cluster: Q14953

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: KI2S5_HUMAN, Q14953
    Similarity: Belongs to the immunoglobulin superfamily
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


    KIR2DS5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KI2S5_HUMAN, Q14953
    Function: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells

         Genatlas biochemistry entry for KIR2DS5:
    natural killer cell immunoglobulin-like activating receptor for HLA-C antigens,2DS5,with alternatively spliced
    (truncated) forms

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030110HLA-C specific inhibitory MHC class I receptor activity NAS8662091
         
    KIR2DS5 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KIR2DS5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Immune System
    Immune System0.56
    Innate Immune System0.50
    2Signaling by FGFR
    DAP12 interactions0.91
    3Allograft rejection
    Antigen processing and presentation0.37
    4Immune response Fc epsilon RI pathway
    Natural killer cell mediated cytotoxicity0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3        Reactome Pathways for KIR2DS5
        DAP12 interactions
    Immune System
    Innate Immune System


    2         Kegg Pathways  (Kegg details for KIR2DS5):
        Antigen processing and presentation
    Natural killer cell mediated cytotoxicity


    KIR2DS5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KIR2DS5

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response NAS8662091
    GO:0045087innate immune response TAS--

    KIR2DS5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KIR2DS5 (KI2S5)

    Search CenterWatch for drugs/clinical trials and news about KIR2DS5 / KI2S5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KIR2DS5 gene: 
    NM_014513.2  

    Unigene Cluster for KIR2DS5:

    Killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5
    Hs.744266
    Unigene Representative Sequence: NM_014513
    miRNA
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    Additional mRNA sequence: 

    AF022047.1 AF208054.1 AF272389.1 AF285439.1 AM851002.1 AY366247.1 AY366248.1 AY789063.2 
    EF370407.1 L76670.1 L76672.1 X97231.1 

    1 DOTS entry:

    DT.86840863 

    24/93 AceView cDNA sequences (see all 93):

    AY223515 AF285434 AY366242 AF034773 AY052497 AF208054 AY052498 U24075 
    BV204358 X99479 AF002979 BM918119 BV180828 BV206441 AF285436 BV199145 
    NM_014219 AF352324 BQ073125 BM917014 X99480 BV206442 BV203729 NM_002255 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KIR2DS5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KIR2DS5 Expression
    About this image


    Genevestigator expression for KIR2DS5

    SOURCE GeneReport for Unigene cluster: Hs.744266
        SABiosciences Custom PCR Arrays for KIR2DS5
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIR2DS5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KIR2DS5 gene
    KIR2DS1  KIR2DS2  KIR2DS4  
    18/57 SIMAP similar genes for KIR2DS5 using alignment to 9 protein entries:     KI2S5_HUMAN (see all proteins) (see all similar genes):
    1060P11.7    KIR2DS2S3    KIR2DS3    KIR2DS2    KIR-K9    KIR2DS1
    KIR412    KIR-K3    KIR-K64    KIR-K36    KIR-K65    KIR2DL1
    KIR2DP1DL1    KIR411    KIR2DL3    KIR-K61    KIR-K78    p58

    KIR2DS5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Locus Specific Mutation Databases (LSDB): KIR2DS5
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604956    OMIM disorders: --

    20/40 diseases for KIR2DS5 (see all 40):    About MalaCards
    leptospirosis    hematopoietic stem cell transplantation    spondyloarthropathy    anterior uveitis
    vogt-koyanagi-harada disease    type 1 diabetes mellitus    tropical spastic paraparesis    bronchiolitis obliterans
    spastic paraparesis    type 1 diabetes    ankylosing spondylitis    uveitis
    familial mediterranean fever    bronchiolitis    chronic myeloid leukemia    leprosy
    spondylitis    behcet's disease    systemic lupus erythematosus    hemophagocytic lymphohistiocytosis


    KIR2DS5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KIR2DS5
    Human Genome Epidemiology (HuGE) Navigator: KIR2DS5 (86 documents)

    Export disorders for KIR2DS5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KIR2DS5 gene, integrated from 9 sources (see all 101):
    (articles sorted by number of sources associating them with KIR2DS5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Alternatively spliced forms of human killer inhibitory receptors. (PubMed id 8662091)1, 2, 3 Dohring C....Colonna M. (1996)
    2. Activating KIR genes are associated with ankylosing spondylitis in Asian populations. (PubMed id 18638658)1, 4, 9 Diaz-Pena R....Lopez-Larrea C. (2008)
    3. Killer immunoglobulin-like receptor ligand HLA-Bw4 pr otects against multiple sclerosis. (PubMed id 19630074)1, 4, 9 Lorentzen A.R....Harbo H.F. (2009)
    4. Killer cell immunoglobulin-like receptor (KIR) genes in the Basque population: association study of KIR gene contents with type 1 diabetes mellitus. (PubMed id 16698433)1, 4, 9 Santin I....Bilbao J.R. (2006)
    5. The beneficial impact of missing KIR ligands and abse nce of donor KIR2DS3 gene on outcome following unrelated hematopoietic SCT for myeloid leukemia in the Chinese population. (PubMed id 20173784)1, 4 Wu G.Q....Huang H. (2010)
    6. HLA-DQA1*0505 sharing and Killer Immunoglobulin-like receptors in sub fertile couples: report of the 15th International Histocompati bility Workshop. (PubMed id 20210919)1, 4 Varla-Leftherioti M....Spyropoulou-Vlachou M. (2010)
    7. Association of killer cell immunoglobulin-like recept or 2DL5 with systemic lupus erythematosus and accompanying infections. (PubMed id 20371502)1, 4 Kimoto Y....Harada M. (2010)
    8. Immunogenetic characteristics of patients with autoim mune gastritis. (PubMed id 20082482)1, 4 Oksanen A.M....Partanen J.A. (2010)
    9. Inhibitory KIR and specific HLA-C gene combinations c onfer susceptibility to or protection against chronic hepatitis B. (PubMed id 20643584)1, 4 Gao X....Zhao Y. (2010)
    10. Association of KIR2DS1 and KIR2DS3 with fatal outcome in Ebola virus infection. (PubMed id 20878400)1, 4 Wauquier N....Vieillard V. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3810 HGNC: 6337 AceView: KIR2DL4 euGenes: HUgn3810 ECgene: KIR2DS5 Kegg: 3810
    H-InvDB: KIR2DS5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KIR2DS5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KIR2DS5 gene:
    Search GeneIP for patents involving KIR2DS5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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