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Aliases for KIR2DS5 Gene

Aliases for KIR2DS5 Gene

  • Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short Cytoplasmic Tail, 5 2 3
  • Natural Killer-Associated Transcript 9 3 4
  • CD158 Antigen-Like Family Member G 3 4
  • MHC Class I NK Cell Receptor 3 4
  • CD158G 3 4
  • NKAT-9 3 4
  • NKAT9 3 4
  • Killer Cell Immunoglobulin-Like Receptor 2DS5 3
  • Natural Killer Cell Inhibitory Receptor 3
  • CD158g Antigen 4

External Ids for KIR2DS5 Gene

Summaries for KIR2DS5 Gene

Entrez Gene Summary for KIR2DS5 Gene

  • Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]

GeneCards Summary for KIR2DS5 Gene

KIR2DS5 (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short Cytoplasmic Tail, 5) is a Protein Coding gene. Diseases associated with KIR2DS5 include hematopoietic stem cell transplantation and hemophagocytic lymphohistiocytosis. Among its related pathways are Signaling by FGFR and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include HLA-C specific inhibitory MHC class I receptor activity.

UniProtKB/Swiss-Prot for KIR2DS5 Gene

  • Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIR2DS5 Gene

Genomics for KIR2DS5 Gene

Genomic Location for KIR2DS5 Gene

Start:
737,826 bp from pter
End:
785,806 bp from pter
Size:
47,981 bases
Orientation:
Plus strand

Genomic View for KIR2DS5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:

RefSeq DNA sequence for KIR2DS5 Gene

No data available for Regulatory Elements for KIR2DS5 Gene

Proteins for KIR2DS5 Gene

  • Protein details for KIR2DS5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14953-KI2S5_HUMAN
    Recommended name:
    Killer cell immunoglobulin-like receptor 2DS5
    Protein Accession:
    Q14953
    Secondary Accessions:

    Protein attributes for KIR2DS5 Gene

    Size:
    304 amino acids
    Molecular mass:
    33644 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KIR2DS5 Gene

Proteomics data for KIR2DS5 Gene at MOPED

Post-translational modifications for KIR2DS5 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn67, Asn84, Asn178, and Asn223

Other Protein References for KIR2DS5 Gene

Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KIR2DS5 Gene

Domains for KIR2DS5 Gene

Gene Families for KIR2DS5 Gene

HGNC:
  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • KIR :Killer cell immunoglobulin-like receptors

Protein Domains for KIR2DS5 Gene

UniProtKB/Swiss-Prot:

KI2S5_HUMAN
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.:
    • Q14953
Family:
  • Belongs to the immunoglobulin superfamily.:
    • Q14953
genes like me logo Genes that share domains with KIR2DS5: view

Function for KIR2DS5 Gene

Molecular function for KIR2DS5 Gene

GENATLAS Biochemistry: natural killer cell immunoglobulin-like activating receptor for HLA-C antigens,2DS5,with alternatively spliced (truncated) forms
UniProtKB/Swiss-Prot Function: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells

Gene Ontology (GO) - Molecular Function for KIR2DS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030110 HLA-C specific inhibitory MHC class I receptor activity NAS 8662091
genes like me logo Genes that share ontologies with KIR2DS5: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KIR2DS5 Gene

Localization for KIR2DS5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIR2DS5 Gene

Cell membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for KIR2DS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 8662091
genes like me logo Genes that share ontologies with KIR2DS5: view

Pathways for KIR2DS5 Gene

genes like me logo Genes that share pathways with KIR2DS5: view

Interacting Proteins for KIR2DS5 Gene

Gene Ontology (GO) - Biological Process for KIR2DS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response NAS 8662091
GO:0007165 signal transduction NAS 8662091
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with KIR2DS5: view

Transcripts for KIR2DS5 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for KIR2DS5 Gene

No ASD Table

Relevant External Links for KIR2DS5 Gene

GeneLoc Exon Structure for
KIR2DS5
ECgene alternative splicing isoforms for
KIR2DS5

Expression for KIR2DS5 Gene

mRNA expression in normal human tissues for KIR2DS5 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for KIR2DS5 Gene

SOURCE GeneReport for Unigene cluster for KIR2DS5 Gene Hs.744266

genes like me logo Genes that share expressions with KIR2DS5: view

Orthologs for KIR2DS5 Gene

No data available for Orthologs and Evolution for KIR2DS5 Gene

Paralogs for KIR2DS5 Gene

genes like me logo Genes that share paralogs with KIR2DS5: view

No data available for Paralogs for KIR2DS5 Gene

Variants for KIR2DS5 Gene

Relevant External Links for KIR2DS5 Gene

HapMap Linkage Disequilibrium report
KIR2DS5
Locus Specific Mutation Databases (LSDB)
KIR2DS5

No data available for Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for KIR2DS5 Gene

Disorders for KIR2DS5 Gene

Relevant External Links for KIR2DS5

Genetic Association Database (GAD)
KIR2DS5
Human Genome Epidemiology (HuGE) Navigator
KIR2DS5
genes like me logo Genes that share disorders with KIR2DS5: view

No data available for UniProtKB/Swiss-Prot for KIR2DS5 Gene

Publications for KIR2DS5 Gene

  1. Killer cell immunoglobulin-like receptor (KIR) genes in the Basque population: association study of KIR gene contents with type 1 diabetes mellitus. (PMID: 16698433) Santin I. … Bilbao J.R. (Hum. Immunol. 2006) 3 23 49
  2. Activating KIR genes are associated with ankylosing spondylitis in Asian populations. (PMID: 18638658) DA-az-PeA+a R. … LA^pez-Larrea C. (Hum. Immunol. 2008) 3 23 49
  3. Alternatively spliced forms of human killer inhibitory receptors. (PMID: 8662091) Doehring C. … Colonna M. (Immunogenetics 1996) 2 3 4
  4. Killer immunoglobulin-like receptor ligand HLA-Bw4 protects against multiple sclerosis. (PMID: 19630074) Lorentzen A.R. … Harbo H.F. (Ann. Neurol. 2009) 3 23 49
  5. KIR and HLA gene combinations in Vogt-Koyanagi-Harada disease. (PMID: 18571006) Levinson R.D. … Rajalingam R. (Hum. Immunol. 2008) 3 49

Products for KIR2DS5 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate KIR2DS5
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for KIR2DS5
    • Block miRNA regulation of KIR2DS5 using miScript Target Protectors

    Sources for KIR2DS5 Gene

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