KIR2DS5 Gene
protein-coding GIFtS: 44
GCID: GC19P9I0009
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killer cell immunoglobulin-like receptor, two domains, short...
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Aliases
for KIR2DS5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short CytoplasmicTail, 51 2 | | MHC Class I NK Cell Receptor2 3 | | CD158G1 2 3 | | Nkat91 | | Natural Killer-Associated Transcript 92 3 | | Killer Cell Immunoglobulin-Like Receptor 2DS52 | | NKAT-92 3 | | Natural Killer Cell Inhibitory Receptor2 | | NKAT92 3 | | CD158g Antigen3 | | CD158 Antigen-Like Family Member G2 3 | | |
Export aliases for KIR2DS5 gene to outside databasesPrevious GC identifers: GC19U990056 GC19P9D0098 GC19P9F0100 GC00P9Q0099 GC19P9H0011 GC19P9H0091 GC19P059937 GC19P9I0098 GC19P9I0022 GC19P055236 |
Summaries
for KIR2DS5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KIR2DS5:
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells andsubsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies amonghaplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). TheKIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they havea long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signalsupon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the shortcytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein totransduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIRproteins are thought to play an important role in regulation of the immune response. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: KI2S5_HUMAN, Q14953Function: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells
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Genomic Views
for KIR2DS5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:NT_113949.1 Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for KIR2DS5
Other transcription factors
Search SABiosciences Chromatin IP Primers for KIR2DS5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIR2DS5 |
Genomic Location:
Chromosome:19
Entrez Gene cytogenetic band: 19q13.4 HGNC cytogenetic band: 19q13.4 GRCh37 novel patchGeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P9I0009: view genomic region
(about GC identifiers)
Start:
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98,112 bp from start of contig NT_113949 |
End:
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113,132 bp from start of contig NT_113949 |
Size:
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15,021 bases |
Orientation:
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plus strand |
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Proteins
for KIR2DS5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KI2S5_HUMAN, Q14953 (See
protein sequence)Recommended Name: Killer cell immunoglobulin-like receptor 2DS5 precursor Size: 304 amino acids; 33644 Da
Subcellular location: Cell membrane; Single-pass type I membrane proteinExplore the universe of human proteins at neXtProt for KIR2DS5: NX_Q14953
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q14953
KIR2DS5 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_055328.2 Reactome Protein details: Q14953
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005887 | integral to plasma membrane |
NAS | 8662091 |
KIR2DS5 for ontologies About GeneDecksing
KIR2DS5 Antibody Products:
Assay Products for KIR2DS5: |
Protein
Domains /
Families
for KIR2DS5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KIR2DS5 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q14953ProtoNet protein and cluster: Q14953 1 Blocks protein family: IPB003599 Immunoglobulin subtype
UniProtKB/Swiss-Prot: KI2S5_HUMAN, Q14953Similarity: Belongs to the immunoglobulin superfamilySimilarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains |
Function
for KIR2DS5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KI2S5_HUMAN, Q14953Function: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells Genatlas biochemistry entry for KIR2DS5:natural killer cell immunoglobulin-like activating receptor for HLA-C antigens,2DS5,with alternatively spliced(truncated) forms
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIR2DS5
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIR2DS5
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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0030110 | HLA-C specific inhibitory MHC class I receptor activity |
NAS | 8662091 |
KIR2DS5 for ontologies About GeneDecksing
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Pathways & Interactions
for KIR2DS5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
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| 1 | Immune System | | | 2 | Natural killer cell mediated cytotoxicity | | | 3 | Signaling by FGFR | | | 4 | Allograft rejection | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 
Reactome Pathways for KIR2DS5
2 
Kegg Pathways (Kegg details for KIR2DS5):
KIR2DS5 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KIR2DS5
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
KIR2DS5 for ontologies About GeneDecksing
|
Drugs & Compounds
for KIR2DS5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KIR2DS5
Search CenterWatch for drugs/clinical trials and news about KIR2DS5 / KI2S5
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Transcripts
for KIR2DS5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KIR2DS5 gene: NM_014513.2 Unigene Cluster for KIR2DS5: Killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5 Hs.744266 Unigene Representative Sequence: NM_014513
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIR2DS5
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIR2DS5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KIR2DS5 (NM_014513) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KIR2DS5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIR2DS5 |
Additional cDNA sequence: AF022047.1 AF208054.1 AF272389.1 AF285439.1 AM851002.1 AY366247.1 AY366248.1 AY789063.2 EF370407.1 L76670.1 L76672.1 X97231.1 1 DOTS entry: DT.86840863 24/93 AceView cDNA sequences (see all 93): AF285434 AY366242 AF034773 AF208054 AY052497 AY052498 AY223515 BC041611 AY366248 BM918119 NM_014219 AY601812 BV204358 X97232 BV204357 X99481 BQ073125 BV180828 AJ417558 AF034772 U73394 Y13054 NM_002255 BV204359
GeneLoc Exon Structure
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Expression
for KIR2DS5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KIR2DS5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
Genevestigator expression for KIR2DS5
SOURCE GeneReport for Unigene cluster: Hs.744266
SABiosciences Custom PCR Arrays for KIR2DS5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIR2DS5
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat KIR2DS5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIR2DS5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIR2DS5 |
Orthologs
for KIR2DS5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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--
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Paralogs
for KIR2DS5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KIR2DS5 gene
- KIR2DS1 KIR2DS2 KIR2DS4
18/54 SIMAP similar genes for KIR2DS5 using alignment to 9 protein entries: KI2S5_HUMAN (see all proteins)
(see all similar genes):1060P11.7 KIR2DS3 KIR2DS2 KIR-K9 KIR2DS1 KIR412
KIR-K3 KIR-K64 KIR-K36 KIR-K65 KIR411 KIR2DL1
KIR2DL3 KIR-K61 KIR-K78 p58 KIR2DL2 KIR-K15
KIR2DS5 for paralogs About GeneDecksing
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Genomic Variants
for KIR2DS5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Locus Specific Mutation Databases (LSDB): KIR2DS5
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for KIR2DS5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KIR2DS5 for disorders About GeneDecksing
OMIM gene information: 604956
OMIM disorders: --
20/39  diseases for KIR2DS5 (see all 39): About MalaCardsvogt-koyanagi-harada disease tropical spastic paraparesis graft versus host disease spastic paraparesis
familial mediterranean fever systemic lupus erythematosus non-hodgkin lymphoma type 1 diabetes mellitus
anterior uveitis systemic lupus erythematosus, association with spontaneous abortion lupus erythematosus
bronchiolitis obliterans ankylosing spondylitis hodgkin's lymphoma diabetes mellitus
spasticity chronic myeloid leukemia uveitis myeloid leukemia
Genetic Association Database (GAD): KIR2DS5
Human Genome Epidemiology (HuGE) Navigator: KIR2DS5 (86 documents)
Export disorders for KIR2DS5 gene to outside databases
|
Publications
for KIR2DS5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KIR2DS5 gene, integrated from 9 sources (see all 98):
(articles sorted by number of sources associating them with KIR2DS5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Alternatively spliced forms of human killer inhibitory receptors. (PubMed id 8662091)1, 2, 3 Dohring C....Colonna M. (1996)
- Distribution of killer cell immunoglobulin-like receptor genes in the Chinese Han population. (PubMed id 15896204)1, 4 Jiang K....Yan L.X. (2005)
- Discovery of two novel variants of KIR2DS5 reveals this gene to be a common component of human KIR 'B' haplotypes. (PubMed id 11144295)1, 9 Vilches C.... Parham P. (2000)
- Activating KIR genes are associated with ankylosing spondylitis in Asian populations. (PubMed id 18638658)1, 9 Diaz-Pena R....Lopez-Larrea C. (2008)
- Killer immunoglobulin-like receptor ligand HLA-Bw4 pr otects against multiple sclerosis. (PubMed id 19630074)1, 9 Lorentzen A.R....Harbo H.F. (2009)
- Killer cell immunoglobulin-like receptor (KIR) genes in the Basque population: association study of KIR gene contents with type 1 diabetes mellitus. (PubMed id 16698433)1, 9 Santin I....Bilbao J.R. (2006)
- Activating KIR2DS5 receptor is a risk for thyroid canc er. (PubMed id 22836040)1 Ashouri E....Ghaderi A. (2012)
- Killer cell immunoglobulin-like receptor gene polymorp hisms predispose susceptibility to Epstein-Barr virus associated hemophagocytic lymphohistiocytosis in Chinese children. (PubMed id 22376216)1 Qiang Q....Kunling S. (2012)
- Killer-cell immunoglobulin-like receptors (KIR) in sev ere A (H1N1) 2009 influenza infections. (PubMed id 22652695)1 Aranda-Romo S....Noyola D.E. (2012)
- Comparison of KIR gene content profiles revealed a di fference between northern and southern Persians in the distribution of KIR2DS5 and its linked loci. (PubMed id 21867738)1 Solgi G....Amirzargar A. (2011)
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External Searches for KIR2DS5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing KIR2DS5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KIR2DS5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KIR2DS5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KIR2DS5 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for KIR2DS5 gene:
Search GeneIP for patents involving KIR2DS5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KIR2DS5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | KIR2DS5 Proteins, Antibodies, CLIAs, and ELISAs |
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