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Aliases for KIR2DS5 Gene

Aliases for KIR2DS5 Gene

  • Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short Cytoplasmic Tail, 5 2 3
  • Natural Killer-Associated Transcript 9 3 4
  • CD158 Antigen-Like Family Member G 3 4
  • MHC Class I NK Cell Receptor 3 4
  • CD158G 3 4
  • NKAT-9 3 4
  • NKAT9 3 4
  • Natural Killer Cell Inhibitory Receptor 3
  • CD158g Antigen 4

External Ids for KIR2DS5 Gene

Previous GeneCards Identifiers for KIR2DS5 Gene

  • GC19U990056
  • GC19P9D0098
  • GC19P9F0100
  • GC00P9Q0099
  • GC19P9H0011
  • GC19P9H0091
  • GC19P059937
  • GC19P9I0098
  • GC19P9I0022
  • GC19P055236
  • GC19P9I0009
  • GC19P9Q0462
  • GC19Pn00737

Summaries for KIR2DS5 Gene

Entrez Gene Summary for KIR2DS5 Gene

  • Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]

GeneCards Summary for KIR2DS5 Gene

KIR2DS5 (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short Cytoplasmic Tail, 5) is a Protein Coding gene. Among its related pathways are Immune System and Interleukin receptor SHC signaling. GO annotations related to this gene include HLA-C specific inhibitory MHC class I receptor activity.

UniProtKB/Swiss-Prot for KIR2DS5 Gene

  • Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIR2DS5 Gene

Genomics for KIR2DS5 Gene

Genomic Location for KIR2DS5 Gene

Chromosome:
19
Start:
30,266 bp from pter
End:
44,854 bp from pter
Size:
14,589 bases
Orientation:
Minus strand

Genomic View for KIR2DS5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for KIR2DS5 Gene

No data available for Regulatory Elements for KIR2DS5 Gene

Proteins for KIR2DS5 Gene

  • Protein details for KIR2DS5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14953-KI2S5_HUMAN
    Recommended name:
    Killer cell immunoglobulin-like receptor 2DS5
    Protein Accession:
    Q14953

    Protein attributes for KIR2DS5 Gene

    Size:
    304 amino acids
    Molecular mass:
    33644 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KIR2DS5 Gene

Proteomics data for KIR2DS5 Gene at MOPED

Post-translational modifications for KIR2DS5 Gene

  • Glycosylation at Asn 67, Asn 84, Asn 178, and Asn 223
  • Modification sites at PhosphoSitePlus

Other Protein References for KIR2DS5 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for KIR2DS5 Gene

Domains & Families for KIR2DS5 Gene

Protein Domains for KIR2DS5 Gene

Suggested Antigen Peptide Sequences for KIR2DS5 Gene

Graphical View of Domain Structure for InterPro Entry

Q14953

UniProtKB/Swiss-Prot:

KI2S5_HUMAN :
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily.
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Family:
  • Belongs to the immunoglobulin superfamily.
genes like me logo Genes that share domains with KIR2DS5: view

Function for KIR2DS5 Gene

Molecular function for KIR2DS5 Gene

GENATLAS Biochemistry:
natural killer cell immunoglobulin-like activating receptor for HLA-C antigens,2DS5,with alternatively spliced (truncated) forms
UniProtKB/Swiss-Prot Function:
Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells

Gene Ontology (GO) - Molecular Function for KIR2DS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030110 HLA-C specific inhibitory MHC class I receptor activity NAS 8662091
genes like me logo Genes that share ontologies with KIR2DS5: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIR2DS5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KIR2DS5 Gene

Localization for KIR2DS5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIR2DS5 Gene

Cell membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for KIR2DS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 8662091
genes like me logo Genes that share ontologies with KIR2DS5: view

No data available for Subcellular locations from COMPARTMENTS for KIR2DS5 Gene

Pathways & Interactions for KIR2DS5 Gene

genes like me logo Genes that share pathways with KIR2DS5: view

Pathways by source for KIR2DS5 Gene

Interacting Proteins for KIR2DS5 Gene

Gene Ontology (GO) - Biological Process for KIR2DS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response NAS 8662091
GO:0007165 signal transduction NAS 8662091
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with KIR2DS5: view

No data available for SIGNOR curated interactions for KIR2DS5 Gene

Drugs & Compounds for KIR2DS5 Gene

No Compound Related Data Available

Transcripts for KIR2DS5 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIR2DS5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIR2DS5 Gene

No ASD Table

Relevant External Links for KIR2DS5 Gene

GeneLoc Exon Structure for
KIR2DS5
ECgene alternative splicing isoforms for
KIR2DS5

Expression for KIR2DS5 Gene

mRNA expression in normal human tissues for KIR2DS5 Gene

Protein differential expression in normal tissues from HIPED for KIR2DS5 Gene

This gene is overexpressed in Nasal epithelium (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KIR2DS5 Gene



SOURCE GeneReport for Unigene cluster for KIR2DS5 Gene Hs.744266

genes like me logo Genes that share expression patterns with KIR2DS5: view

Protein tissue co-expression partners for KIR2DS5 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KIR2DS5 Gene

Orthologs for KIR2DS5 Gene

No data available for Orthologs and Evolution for KIR2DS5 Gene

Paralogs for KIR2DS5 Gene

genes like me logo Genes that share paralogs with KIR2DS5: view

No data available for Paralogs for KIR2DS5 Gene

Variants for KIR2DS5 Gene

Sequence variations from dbSNP and Humsavar for KIR2DS5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs585644 -- 1(-) tgcac(A/G)ccacc intron-variant
rs612997 -- 1(-) CTTCT(C/G)AGAGG utr-variant-3-prime
rs680042 -- 1(-) cacca(C/T)gccag intron-variant
rs1654643 -- 1(-) CACCT(A/G)CATGT reference, synonymous-codon
rs1743307 -- 1(-) ataca(C/T)agata intron-variant

Relevant External Links for KIR2DS5 Gene

HapMap Linkage Disequilibrium report
KIR2DS5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for KIR2DS5 Gene

Disorders for KIR2DS5 Gene

Relevant External Links for KIR2DS5

Genetic Association Database (GAD)
KIR2DS5
Human Genome Epidemiology (HuGE) Navigator
KIR2DS5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIR2DS5
genes like me logo Genes that share disorders with KIR2DS5: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIR2DS5 Gene

Publications for KIR2DS5 Gene

  1. Distribution of KIR genes in the Iranian population. (PMID: 19392787) Tajik N. … Radjabzadeh M.F. (Tissue Antigens 2009) 23 67
  2. Killer immunoglobulin-like receptor ligand HLA-Bw4 protects against multiple sclerosis. (PMID: 19630074) Lorentzen A.R. … Harbo H.F. (Ann. Neurol. 2009) 23 67
  3. Activating KIR genes are associated with ankylosing spondylitis in Asian populations. (PMID: 18638658) DA-az-PeA+a R. … LA^pez-Larrea C. (Hum. Immunol. 2008) 23 67
  4. Killer cell immunoglobulin-like receptor (KIR) genes in the Basque population: association study of KIR gene contents with type 1 diabetes mellitus. (PMID: 16698433) Santin I. … Bilbao J.R. (Hum. Immunol. 2006) 23 67
  5. Distribution of killer cell immunoglobulin-like receptors in the Greek population. (PMID: 14630399) Niokou D. … Stavropoulos-Giokas C. (Hum. Immunol. 2003) 23 67

Products for KIR2DS5 Gene

Sources for KIR2DS5 Gene

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