Aliases for KIR2DS5 Gene
Previous GeneCards Identifiers for KIR2DS5 Gene
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
GeneCards Summary for KIR2DS5 Gene
KIR2DS5 (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short Cytoplasmic Tail, 5) is a Protein Coding gene. Diseases associated with KIR2DS5 include hematopoietic stem cell transplantation and hemophagocytic lymphohistiocytosis. Among its related pathways are Signaling by FGFR and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include HLA-C specific inhibitory MHC class I receptor activity.
UniProtKB/Swiss-Prot for KIR2DS5 Gene
Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells