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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KIR2DS4 Gene

protein-coding   GIFtS: 54
GCID: GC19P055344

Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short
Cytoplasmic Tail, 41 2
     P58 NK Receptor CL-39/CL-172 3
NKAT82 3 5     KIR1D2
Natural Killer-Associated Transcript 82 3     KIR4122
CD158I2 3     Killer Cell Immunoglobulin-Like Receptor 2DS42
KKA32 3     Killer Inhibitory Receptor 4-1-22
NKAT-82 3     KIR Antigen 2DS42
CD158 Antigen-Like Family Member I2 3     Natural Killer Cell Inhibitory Receptor2
MHC Class I NK Cell Receptor2 3     CD158i Antigen3
P58 Natural Killer Cell Receptor Clones CL-39/CL-172 3     

External Ids:    HGNC: 63361   Entrez Gene: 38092   Ensembl: ENSG000002219577   OMIM: 6049555   UniProtKB: P436323   

Export aliases for KIR2DS4 gene to outside databases

Previous GC identifers: GC19U990055 GC19P055663 GC19P060004 GC19P060035 GC19P059931 GC19P051666


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KIR2DS4 Gene:
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells
and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on
chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster
varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1,
KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or
3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic
domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM),
while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO
protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are
subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the
immune response. (provided by RefSeq, Jul 2008)

GeneCards Summary for KIR2DS4 Gene: 
KIR2DS4 (killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4) is a protein-coding gene. Diseases associated with KIR2DS4 include craniofacial deafness hand syndrome, and birdshot chorioretinopathy, and among its related super-pathways are Immune System and DAP12 signaling. An important paralog of this gene is LILRB4.

UniProtKB/Swiss-Prot: KI2S4_HUMAN, P43632
Function: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells

Gene Wiki entry for KIR2DS4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KIR2DS4 gene promoter:
         CREB   p53   deltaCREB   STAT5A   CUTL1   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKIR2DS4 promoter sequence
   Search SABiosciences Chromatin IP Primers for KIR2DS4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIR2DS4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.4

KIR2DS4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIR2DS4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P055344:  view genomic region     (about GC identifiers)

Start:
55,344,131 bp from pter      End:
55,360,024 bp from pter
Size:
15,894 bases      Orientation:
plus strand

4 alternative locations:
Chr19+,NW_003571060 737,088-752,959      Chr19+,NW_003571058 819,632-830,489      Chr19+,NW_003571055 479,324-493,823     
Chr19+,NW_003571056 812,597-828,446     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KI2S4_HUMAN, P43632 (See protein sequence)
Recommended Name: Killer cell immunoglobulin-like receptor 2DS4 precursor  
Size: 304 amino acids; 33583 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein
Sequence caution: Sequence=AAC50336.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for KIR2DS4:
3H8N (3D)    
Secondary accessions: Q6H2G7

Explore the universe of human proteins at neXtProt for KIR2DS4: NX_P43632

Explore proteomics data for KIR2DS4 at MOPED 

KIR2DS4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

KIR2DS4 Protein Expression

REFSEQ proteins (3 alternative transcripts): 
NP_001268900.1  NP_001268901.1  NP_036446.3  

ENSEMBL proteins: 
 ENSP00000340011   ENSP00000375609  
Reactome Protein details: P43632
Human Recombinant Protein Products for KIR2DS4: 
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Cloud-Clone Corp. Proteins for KIR2DS4 

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0005887integral to plasma membrane TAS7749980

KIR2DS4 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
CD: CD molecules
KIR: Killer cell immunoglobulin-like receptors
IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

3 InterPro protein domains:
 IPR003599 Ig_sub
 IPR013783 Ig-like_fold
 IPR013151 Immunoglobulin

Graphical View of Domain Structure for InterPro Entry P43632

ProtoNet protein and cluster: P43632

1 Blocks protein domain: IPB003599 Immunoglobulin subtype

UniProtKB/Swiss-Prot: KI2S4_HUMAN, P43632
Similarity: Belongs to the immunoglobulin superfamily
Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


KIR2DS4 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: KI2S4_HUMAN, P43632
Function: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells

     Genatlas biochemistry entry for KIR2DS4:
natural killer cell immunoglobulin-like activating receptor for HLA-C antigens,2DS4,with alternatively spliced
(truncated) forms

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for KIR2DS4 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KIR2DS4

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KIR2DS4 
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miRNA
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Inhib. RNA
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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for KIR2DS4 About                                                                                                See pathways by source

SuperPathContained pathways About
1Immune System
Immune System0.56
Innate Immune System0.50
2Signaling by FGFR
DAP12 interactions0.91
3Allograft rejection
Antigen processing and presentation0.37
4Immune response Fc epsilon RI pathway
Natural killer cell mediated cytotoxicity0.31

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


3        Reactome Pathways for KIR2DS4
    DAP12 interactions
Immune System
Innate Immune System


2         Kegg Pathways  (Kegg details for KIR2DS4):
    Antigen processing and presentation
Natural killer cell mediated cytotoxicity


KIR2DS4 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KIR2DS4

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

5/6 Interacting proteins for KIR2DS4 (P436323 ENSP000003400114) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
InteractantInteraction Details
GeneCardExternal ID(s)
HLA-CP103213, ENSP000003654024I2D: score=1 STRING: ENSP00000365402
TYROBPENSP000002626294STRING: ENSP00000262629
ENSG00000223532ENSP000004008424STRING: ENSP00000400842
ENSG00000229252ENSP000004099104STRING: ENSP00000409910
ENSG00000237216ENSP000004091324STRING: ENSP00000409132
About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0045087innate immune response TAS--

KIR2DS4 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

KIR2DS4 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KIR2DS4 (KI2S4)

3 Novoseek inferred chemical compound relationships for KIR2DS4 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine 0 1 9124036 (1)
retinoic acid 0 2 7554921 (1), 9004232 (1)
cysteine 0 1 17313188 (1)

Search CenterWatch for drugs/clinical trials and news about KIR2DS4 / KI2S4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KIR2DS4 gene (3 alternative transcripts): 
NM_001281971.1  NM_001281972.1  NM_012314.4  

Unigene Cluster for KIR2DS4:

Killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4
Hs.654608  [show with all ESTs]
Unigene Representative Sequence: NM_012314
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000339924(uc010yfk.1 uc010esg.1 uc002qhm.1) ENST00000391729(uc010yfj.2 uc002qhn.1)

miRNA
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Inhib. RNA
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIR2DS4

Additional mRNA sequence: 

AF002255.1 AF135556.1 AF135563.1 AJ417555.1 AY102623.1 AY102624.1 AY366245.1 AY388472.1 
BC096694.1 BC101977.1 BC103693.1 BC108918.1 BC125147.1 BC127084.1 BC144566.1 BC171788.1 
L76671.1 U24077.1 U96188.1 X94609.1 

3 DOTS entries:

DT.95344540  DT.40115449  DT.97842818 

3 AceView cDNA sequences:

NM_012314 AJ417554 NM_178228 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KIR2DS4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
KIR2DS4 Expression
About this image


See KIR2DS4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KIR2DS4

SOURCE GeneReport for Unigene cluster: Hs.654608
    SABiosciences Custom PCR Arrays for KIR2DS4
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIR2DS4
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIR2DS4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
  --

ENSEMBL Gene Tree for KIR2DS4 (if available)
TreeFam Gene Tree for KIR2DS4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for KIR2DS4 gene
KIR2DS2  KIR2DS1  KIR2DS5  LILRB42  KIR2DL42  LILRB12  LILRA62  LILRA52  
IGSF12  KIR3DL12  OSCAR2  NCR12  LILRA42  ENSG000002177922  TARM12  KIR3DX12  
LILRA32  LILRB52  KIR3DL32  LILRA12  KIR3DS12  KIR2DL12  LILRB22  A1BG2  
KIR3DL22  LILRA22  KIR2DL32  FCAR2  GP62  LILRB32  
18/59 SIMAP similar genes for KIR2DS4 using alignment to 16 protein entries:     KI2S4_HUMAN (see all proteins) (see all similar genes):
KIR2DS    KIR-K15    KIR-K78    KIR-K61    KIR-K65    KIR411
KIR-K36    p58    KIR2DS2    KIR2DS1    KIR2DS2S3    KIR412
KIR2DL2    KIR-K64    KIR2DL3    KIR2DL1    KIR2DP1DL1    KIR-K3

KIR2DS4 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/751 SNPs in KIR2DS4 are shown (see all 751)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0594254
----see VAR_0594252 K N mis40--------
rs724891471,2
C--55342744(+) TAATCA/TAGAGA 1 -- us2k10--------
rs2000381571,2
C--55342762(+) ATGTAC/TACAGG 1 -- us2k10--------
rs3731201211,2
C--55342808(+) TTTTAC/TTAAGA 1 -- us2k10--------
rs1135643091,2
C--55342837(+) ATTTTG/AGTACC 1 -- us2k11Minor allele frequency- A:0.50NA 2
rs763464361,2
C,F--55342841(+) TGGTAC/TCTGAG 1 -- us2k12Minor allele frequency- T:0.50NA 8
rs724891481,2
C,F--55342872(+) ACCCAC/G/TGAATA 1 -- us2k11NA 4
rs726291081,2
C,F--55342880(+) ATAGTG/AAAGGA 1 -- us2k11Minor allele frequency- A:0.33NA 6
rs2003212831,2
C--55342896(+) GTATAA/G/TGACTT 1 -- us2k10--------
rs2015682611,2
C--55342913(+) CTCAAA/TTTTAA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for KIR2DS4 (55344131 - 55360024 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/47 variations for KIR2DS4 (see all 47):    About this table     
Variant IDTypeSubtypePubMed ID
esv2668549CNV Deletion23128226
esv2667609CNV Deletion23128226
esv2665895CNV Deletion23128226
esv2661467CNV Deletion23128226
esv2421952CNV Deletion20811451
esv2718872CNV Deletion23290073
dgv577e201CNV Deletion23290073
esv2718932CNV Deletion23290073
dgv667e199CNV Deletion23128226
esv2718931CNV Deletion23290073


Locus Specific Mutation Databases (LSDB): KIR2DS4
SABiosciences Cancer Mutation PCR Assays
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DNA2.0 Custom Variant and Variant Library Synthesis for KIR2DS4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 604955    OMIM disorders: --

20/58 diseases for KIR2DS4 (see all 58):    About MalaCards
craniofacial deafness hand syndrome    birdshot chorioretinopathy    klippel-feil syndrome    listeriosis
embryonal rhabdomyosarcoma    paroxysmal nocturnal hemoglobinuria    aniridia    waardenburg's syndrome
anterior uveitis    coloboma    cutaneous malignant melanoma    leptospirosis
hemoglobinuria    vogt-koyanagi-harada disease    congenital hypothyroidism    spondyloarthropathy
tropical spastic paraparesis    spastic paraparesis    uveitis    familial mediterranean fever


KIR2DS4 for disorders           About GeneDecksing

8 Novoseek inferred disease relationships for KIR2DS4 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
waardenburgs syndrome 84.4 4 9297966 (1), 8735950 (1), 7712527 (1), 8664898 (1)
aniridia 76.1 3 9297966 (1), 8735950 (1), 1684639 (1)
coloboma 37.2 1 9297966 (1)
craniofacial anomaly 31.6 1 7554921 (1)
medulloblastoma 15 1 11477548 (1)
leukemia 0 1 11841448 (1)
tumors 0 4 8735950 (1), 8817414 (1), 19016056 (1), 9834843 (1)
cancer 0 9 9834843 (1)

Genetic Association Database (GAD): KIR2DS4
Human Genome Epidemiology (HuGE) Navigator: KIR2DS4 (94 documents)

Export disorders for KIR2DS4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for KIR2DS4 gene, integrated from 9 sources (see all 231):
(articles sorted by number of sources associating them with KIR2DS4)
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  1. A novel surface molecule homologous to the p58/p50 family of receptors is selectively expressed on a subset of human natural killer cells and induces both triggering of cell functions and proliferation. (PubMed id 8765026)1, 2, 3 Bottino C....Moretta A. (1996)
  2. Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains. (PubMed id 7749980)1, 2, 3 Wagtmann N....Long E.O. (1995)
  3. KIR3DL1/S1 genotypes and KIR2DS4 allelic variants in the AB KIR genotypes are associated with Plasmodium-positive individuals in mal aria infection. (PubMed id 19859704)1, 4, 9 Taniguchi M. and Kawabata M. (2009)
  4. Distribution of killer cell immunoglobulin-like recep tor genes and 2DS4 alleles in the Chinese Han population. (PubMed id 20034528)1, 4, 9 Bao X....He J. (2010)
  5. Killer immunoglobulin-like receptor ligand HLA-Bw4 pr otects against multiple sclerosis. (PubMed id 19630074)1, 4, 9 Lorentzen A.R....Harbo H.F. (2009)
  6. Killer cell immunoglobulin-like receptor allele discr imination by high-resolution melting. (PubMed id 19589363)1, 4, 9 Gonzalez A....Middleton D. (2009)
  7. Impact of a functional KIR2DS4 allele on heterosexual HIV-1 transmission among discordant Zambian couples. (PubMed id 21216870)1, 4 Merino A....Kaslow R.A. (2011)
  8. Association of killer cell immunoglobulin-like recept or 2DL5 with systemic lupus erythematosus and accompanying infections. (PubMed id 20371502)1, 4 Kimoto Y....Harada M. (2010)
  9. Immunogenetic characteristics of patients with autoim mune gastritis. (PubMed id 20082482)1, 4 Oksanen A.M....Partanen J.A. (2010)
  10. Association of KIR2DS1 and KIR2DS3 with fatal outcome in Ebola virus infection. (PubMed id 20878400)1, 4 Wauquier N....Vieillard V. (2010)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3809 HGNC: 6336 AceView: KIR2DS4 Ensembl:ENSG00000221957 euGenes: HUgn3809
ECgene: KIR2DS4 Kegg: 3809 H-InvDB: KIR2DS4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for KIR2DS4 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for KIR2DS4 gene:
Search GeneIP for patents involving KIR2DS4

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