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KIR2DS4 Gene

protein-coding   GIFtS: 54
GCID: GC19P055344

Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short
Cytoplasmic Tail, 41 2
     KIR1D2
NKAT82 3 5     KIR2DS12
Natural Killer-Associated Transcript 82 3     KIR4122
CD158I2 3     Killer Cell Immunoglobulin-Like Receptor 2DS42
KKA32 3     Killer Cell Immunoglobulin-Like Receptor Two Domains Short Cytoplasmic
Tail 12
NKAT-82 3     Killer Ig Receptor2
CD158 Antigen-Like Family Member I2 3     Killer Inhibitory Receptor 4-1-22
MHC Class I NK Cell Receptor2 3     KIR Antigen 2DS42
P58 Natural Killer Cell Receptor Clones CL-39/CL-172 3     Natural Killer Cell Inhibitory Receptor2
P58 NK Receptor CL-39/CL-172 3     CD158i Antigen3

External Ids:    HGNC: 63361   Entrez Gene: 38092   Ensembl: ENSG000002219577   OMIM: 6049555   UniProtKB: P436323   

Export aliases for KIR2DS4 gene to outside databases

Previous GC identifers: GC19U990055 GC19P055663 GC19P060004 GC19P060035 GC19P059931 GC19P051666


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KIR2DS4 Gene:
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells
and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on
chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster
varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1,
KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or
3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic
domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM),
while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO
protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are
subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the
immune response. (provided by RefSeq, Jul 2008)

GeneCards Summary for KIR2DS4 Gene:
KIR2DS4 (killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4) is a protein-coding gene. Diseases associated with KIR2DS4 include craniofacial deafness hand syndrome, and birdshot chorioretinopathy. An important paralog of this gene is LILRB4.

UniProtKB/Swiss-Prot: KI2S4_HUMAN, P43632
Function: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells

Gene Wiki entry for KIR2DS4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  NT_187637.1  NT_187638.1  NT_187639.1  NT_187640.1  NT_187642.1  
NT_187643.1  NT_187645.1  NT_187668.1  NT_187669.1  NT_187671.1  NT_187673.1  NT_187674.1  NT_187676.1  
NT_187677.1  NT_187683.1  NT_187684.1  NT_187685.1  NT_187686.1  NT_187687.1  NT_187693.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the KIR2DS4 gene promoter:
         CREB   p53   deltaCREB   STAT5A   CUTL1   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKIR2DS4 promoter sequence
   Search Chromatin IP Primers for KIR2DS4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KIR2DS4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.4

KIR2DS4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIR2DS4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P055344:  view genomic region     (about GC identifiers)

Start:
55,344,131 bp from pter      End:
55,360,024 bp from pter
Size:
15,894 bases      Orientation:
plus strand

4 alternative locations:
Chr19+,NW_003571060 737,088-752,959      Chr19+,NW_003571055 479,324-493,823      Chr19+,NW_003571056 812,597-828,446     
Chr19+,NW_003571058 819,632-830,489     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KI2S4_HUMAN, P43632 (See protein sequence)
Recommended Name: Killer cell immunoglobulin-like receptor 2DS4 precursor  
Size: 304 amino acids; 33583 Da
Sequence caution: Sequence=AAC50336.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for KIR2DS4:
3H8N (3D)    
Secondary accessions: Q6H2G7

Explore the universe of human proteins at neXtProt for KIR2DS4: NX_P43632

Explore proteomics data for KIR2DS4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn67, Asn84, Asn144, Asn178, Asn211

  • See KIR2DS4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001268900.1  NP_001268901.1  NP_036446.3  

    ENSEMBL proteins: 
     ENSP00000340011   ENSP00000375609  
    Reactome Protein details: P43632

    KIR2DS4 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    KIR: Killer cell immunoglobulin-like receptors
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    3 InterPro protein domains:
     IPR003599 Ig_sub
     IPR013783 Ig-like_fold
     IPR013151 Immunoglobulin

    Graphical View of Domain Structure for InterPro Entry P43632

    ProtoNet protein and cluster: P43632

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: KI2S4_HUMAN, P43632
    Similarity: Belongs to the immunoglobulin superfamily
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


    KIR2DS4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KI2S4_HUMAN, P43632
    Function: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells

         Genatlas biochemistry entry for KIR2DS4:
    natural killer cell immunoglobulin-like activating receptor for HLA-C antigens,2DS4,with alternatively spliced
    (truncated) forms

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KIR2DS4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KIR2DS4
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KI2S4_HUMAN, P43632: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular3
    endoplasmic reticulum1
    lysosome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS7749980

    KIR2DS4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KIR2DS4 About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by FGFR
    DAP12 interactions0.89
    2Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    3Allograft rejection
    Antigen processing and presentation0.36
    4Immune response Role of DAP12 receptors in NK cells
    Natural killer cell mediated cytotoxicity0.31
    5Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for KIR2DS4
        DAP12 interactions


    2 Kegg Pathways  (Kegg details for KIR2DS4):
        Antigen processing and presentation
    Natural killer cell mediated cytotoxicity


    KIR2DS4 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KIR2DS4
    Interactions:

        GeneGlobe Interaction Network for KIR2DS4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for KIR2DS4 (P436323 ENSP000003400114) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HLA-CP103213, ENSP000003654024I2D: score=1 STRING: ENSP00000365402
    TYROBPENSP000002626294STRING: ENSP00000262629
    ENSG00000223532ENSP000004008424STRING: ENSP00000400842
    ENSG00000229252ENSP000004099104STRING: ENSP00000409910
    ENSG00000237216ENSP000004091324STRING: ENSP00000409132
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045087innate immune response TAS--

    KIR2DS4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KIR2DS4 (KI2S4)

    3 Novoseek inferred chemical compound relationships for KIR2DS4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 0 1 9124036 (1)
    retinoic acid 0 2 7554921 (1), 9004232 (1)
    cysteine 0 1 17313188 (1)



    KIR2DS4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KIR2DS4 gene (3 alternative transcripts): 
    NM_001281971.1  NM_001281972.1  NM_012314.5  

    Unigene Cluster for KIR2DS4:

    Killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4
    Hs.654608  [show with all ESTs]
    Unigene Representative Sequence: NM_012314
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000339924(uc010yfk.1 uc010esg.1 uc002qhm.1) ENST00000391729(uc010yfj.2 uc002qhn.1)

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      QuantiFast Probe-based Assays in human, mouse, rat KIR2DS4

    Additional mRNA sequence: 

    AF002255.1 AF135556.1 AF135563.1 AJ417555.1 AY102623.1 AY102624.1 AY366245.1 AY388472.1 
    BC096694.1 BC101977.1 BC103693.1 BC108918.1 BC125147.1 BC127084.1 BC144566.1 BC171788.1 
    L76671.1 U24077.1 U96188.1 X94609.1 

    3 DOTS entries:

    DT.95344540  DT.40115449  DT.97842818 

    3 AceView cDNA sequences:

    NM_178228 NM_012314 AJ417554 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KIR2DS4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KIR2DS4 Expression
    About this image

    KIR2DS4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KIR2DS4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654608
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KIR2DS4 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    10(a)
    1 → many
    GL343329.1(1197670-1218701)
            Species with no ortholog for KIR2DS4

    ENSEMBL Gene Tree for KIR2DS4 (if available)
    TreeFam Gene Tree for KIR2DS4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KIR2DS4 gene
    LILRB42  KIR2DL42  LILRB12  LILRA62  LILRA52  IGSF12  KIR3DL12  OSCAR2  
    NCR12  LILRA42  ENSG000002177922  TARM12  KIR3DX12  LILRA32  LILRB52  KIR3DL32  
    LILRA12  KIR3DS12  KIR2DL12  LILRB22  A1BG2  KIR3DL22  LILRA22  KIR2DL32  
    FCAR2  GP62  LILRB32  
    Selected SIMAP similar genes for KIR2DS4 using alignment to 16 protein entries:     KI2S4_HUMAN (see all proteins) (see all similar genes):
    KIR2DS    KIR-K15    KIR-K78    KIR-K61    KIR-K65    KIR411
    KIR-K36    p58    KIR2DS2    KIR2DS1    KIR2DS2S3    KIR2DL2
    KIR412    KIR-K64    KIR2DL3    KIR2DP1DL1    KIR2DL1    KIR-K3

    KIR2DS4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KIR2DS4 (see all 751)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs724891471,2
    C--55342744(+) TAATCA/TAGAGA 1 -- us2k10--------
    rs2000381571,2
    C--55342762(+) ATGTAC/TACAGG 1 -- us2k10--------
    rs3731201211,2
    C--55342808(+) TTTTAC/TTAAGA 1 -- us2k10--------
    rs1135643091,2
    C--55342837(+) ATTTTG/AGTACC 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs763464361,2
    C,F--55342841(+) TGGTAC/TCTGAG 1 -- us2k12Minor allele frequency- T:0.50NA 8
    rs724891481,2
    C,F--55342872(+) ACCCAC/G/TGAATA 1 -- us2k11NA 4
    rs726291081,2
    C,F--55342880(+) ATAGTG/AAAGGA 1 -- us2k11Minor allele frequency- A:0.33NA 6
    rs2003212831,2
    C--55342896(+) GTATAA/G/TGACTT 1 -- us2k10--------
    rs2015682611,2
    C--55342913(+) CTCAAA/TTTTAA 1 -- us2k10--------
    rs3688898241,2
    C--55342957(+) TAAAA-/GTAAGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KIR2DS4 (55344131 - 55360024 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for KIR2DS4 (see all 47):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2668549CNV Deletion23128226
    esv2667609CNV Deletion23128226
    esv2665895CNV Deletion23128226
    esv2661467CNV Deletion23128226
    esv2421952CNV Deletion20811451
    esv2718872CNV Deletion23290073
    dgv577e201CNV Deletion23290073
    esv2718932CNV Deletion23290073
    dgv667e199CNV Deletion23128226
    esv2718931CNV Deletion23290073

    Locus Specific Mutation Databases (LSDB): KIR2DS4

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604955    OMIM disorders: --

    Selected diseases for KIR2DS4 (see all 63):    
    About MalaCards
    craniofacial deafness hand syndrome    birdshot chorioretinopathy    klippel-feil syndrome    embryonal rhabdomyosarcoma
    listeriosis    aniridia    paroxysmal nocturnal hemoglobinuria    waardenburg's syndrome
    hematopoietic stem cell transplantation    cutaneous malignant melanoma    coloboma    cytomegalovirus infection
    anterior uveitis    leptospirosis    vogt-koyanagi-harada disease    hemoglobinuria
    spondyloarthropathy    congenital hypothyroidism    syphilis    tropical spastic paraparesis


    KIR2DS4 for disorders           About GeneDecksing

    8 Novoseek inferred disease relationships for KIR2DS4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    waardenburgs syndrome 84.4 4 9297966 (1), 8735950 (1), 7712527 (1), 8664898 (1)
    aniridia 76.1 3 9297966 (1), 8735950 (1), 1684639 (1)
    coloboma 37.2 1 9297966 (1)
    craniofacial anomaly 31.6 1 7554921 (1)
    medulloblastoma 15 1 11477548 (1)
    leukemia 0 1 11841448 (1)
    tumors 0 4 8735950 (1), 8817414 (1), 19016056 (1), 9834843 (1)
    cancer 0 9 9834843 (1)

    Genetic Association Database (GAD): KIR2DS4
    Human Genome Epidemiology (HuGE) Navigator: KIR2DS4 (94 documents)

    Export disorders for KIR2DS4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KIR2DS4 gene, integrated from 10 sources (see all 234):
    (articles sorted by number of sources associating them with KIR2DS4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel surface molecule homologous to the p58/p50 family of receptors is selectively expressed on a subset of human natural killer cells and induces both triggering of cell functions and proliferation. (PubMed id 8765026)1, 2, 3 Bottino C....Moretta A. (Eur. J. Immunol. 1996)
    2. Molecular clones of the p58 NK cell receptor reveal immunoglobulin- related molecules with diversity in both the extra- and intracellular domains. (PubMed id 7749980)1, 2, 3 Wagtmann N.... Long E.O. (Immunity 1995)
    3. KIR3DL1/S1 genotypes and KIR2DS4 allelic variants in the AB KIR genotypes are associated with Plasmodium-positive individuals in malaria infection. (PubMed id 19859704)1, 4, 9 Taniguchi M. and Kawabata M. (Immunogenetics 2009)
    4. Distribution of killer cell immunoglobulin-like receptor genes and 2DS4 alleles in the Chinese Han population. (PubMed id 20034528)1, 4, 9 Bao X....He J. (Hum. Immunol. 2010)
    5. Killer immunoglobulin-like receptor ligand HLA-Bw4 protects against multiple sclerosis. (PubMed id 19630074)1, 4, 9 Lorentzen A.R....Harbo H.F. (Ann. Neurol. 2009)
    6. Killer cell immunoglobulin-like receptor allele discrimination by high-resolution melting. (PubMed id 19589363)1, 4, 9 Gonzalez A....Middleton D. (Hum. Immunol. 2009)
    7. Impact of a functional KIR2DS4 allele on heterosexual HIV-1 transmission among discordant Zambian couples. (PubMed id 21216870)1, 4 Merino A....Kaslow R.A. (J. Infect. Dis. 2011)
    8. Association of killer cell immunoglobulin-like receptor 2DL5 with systemic lupus erythematosus and accompanying infections. (PubMed id 20371502)1, 4 Kimoto Y....Harada M. (Rheumatology (Oxford) 2010)
    9. Immunogenetic characteristics of patients with autoimmune gastritis. (PubMed id 20082482)1, 4 Oksanen A.M....Partanen J.A. (World J. Gastroenterol. 2010)
    10. Association of KIR2DS1 and KIR2DS3 with fatal outcome in Ebola virus infection. (PubMed id 20878400)1, 4 Wauquier N....Vieillard V. (Immunogenetics 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
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      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3809 HGNC: 6336 AceView: KIR2DS4 Ensembl:ENSG00000221957 euGenes: HUgn3809
    ECgene: KIR2DS4 Kegg: 3809 H-InvDB: KIR2DS4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KIR2DS4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KIR2DS4 gene:
    Search GeneIP for patents involving KIR2DS4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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