KIR2DS3 Gene
protein-coding GIFtS: 38
GCID: GC19U901482
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killer cell immunoglobulin-like receptor, two domains, short...
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Aliases
for KIR2DS3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
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| Aliases |
|---|
| Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short CytoplasmicTail, 31 2 | | MHC Class I NK Cell Receptor2 3 | | NKAT72 3 5 | | Nkat71 | | Natural Killer-Associated Transcript 72 3 | | Killer Cell Immunoglobulin-Like Receptor 2DS32 | | NKAT-72 3 | | Natural Killer Cell Inhibitory Receptor2 |
Export aliases for KIR2DS3 gene to outside databasesPrevious GC identifers: GC19P055480 GC19P9D0099 GC19P9F0099 GC00P9Q0098 GC19P9H0010 GC19P059933 GC19P9H0090 GC19P9I0099 GC19P9I0023 GC19P9I0100 GC19P055235 |
Summaries
for KIR2DS3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KIR2DS3:
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells andsubsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies amonghaplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). TheKIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they havea long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signalsupon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the shortcytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein totransduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIRproteins are thought to play an important role in regulation of the immune response. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: KI2S3_HUMAN, Q14952Function: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells
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Genomic Views
for KIR2DS3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for KIR2DS3
Other transcription factors
Search SABiosciences Chromatin IP Primers for KIR2DS3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIR2DS3 |
Genomic Location:
Chromosome:19
Entrez Gene cytogenetic band: 19q13.4 HGNC cytogenetic band: 19q13.4 unplacedGeneLoc information about chromosome 19 |
Proteins
for KIR2DS3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: KI2S3_HUMAN, Q14952 (See
protein sequence)Recommended Name: Killer cell immunoglobulin-like receptor 2DS3 precursor Size: 304 amino acids; 33717 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein
Secondary accessions: O00644Explore the universe of human proteins at neXtProt for KIR2DS3: NX_Q14952
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q14952
KIR2DS3 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_036445.1
Human Recombinant Protein Products for KIR2DS3:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005887 | integral to plasma membrane |
TAS | 8765026 |
KIR2DS3 for ontologies About GeneDecksing
KIR2DS3 Antibody Products:
Assay Products for KIR2DS3: |
Protein
Domains /
Families
for KIR2DS3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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KIR2DS3 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q14952ProtoNet protein and cluster: Q14952 1 Blocks protein family: IPB003599 Immunoglobulin subtype
UniProtKB/Swiss-Prot: KI2S3_HUMAN, Q14952Similarity: Belongs to the immunoglobulin superfamilySimilarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains |
Function
for KIR2DS3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Molecular Function:
UniProtKB/Swiss-Prot Summary: KI2S3_HUMAN, Q14952Function: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells Genatlas biochemistry entry for KIR2DS3:natural killer cell immunoglobulin-like activating receptor for HLA-C antigens,2DS3,with alternatively spliced(truncated) forms
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIR2DS3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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Synthesis Service for KIR2DS3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIR2DS3 |
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Pathways & Interactions
for KIR2DS3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
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| 1 | Natural killer cell mediated cytotoxicity | | | 2 | Allograft rejection | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Kegg Pathways (Kegg details for KIR2DS3):
KIR2DS3 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIR2DS3
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0006968 | cellular defense response |
TAS | 8765026 |
KIR2DS3 for ontologies About GeneDecksing
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Drugs & Compounds
for KIR2DS3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KIR2DS3
Search CenterWatch for drugs/clinical trials and news about KIR2DS3 / KI2S3
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Transcripts
for KIR2DS3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KIR2DS3 gene: NM_012313.1
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIR2DS3
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIR2DS3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KIR2DS3 (NM_012313) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KIR2DS3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIR2DS3 |
24/93 AceView cDNA sequences (see all 93): AY366242 AY052498 AF208054 AF285434 AY223515 AF034773 AY052497 AF002979 AY223512 AF285436 AJ417558 AY250088 BV183858 AY366247 X97232 BV199144 AF276292 BV199186 NM_014219 BX952500 L76668 AF002256 BV180829 AF135566
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Expression
for KIR2DS3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KIR2DS3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
Genevestigator expression for KIR2DS3
SABiosciences Custom PCR Arrays for KIR2DS3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIR2DS3
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat KIR2DS3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIR2DS3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIR2DS3 |
Orthologs
for KIR2DS3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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--
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Paralogs
for KIR2DS3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
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Genomic Variants
for KIR2DS3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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Human Gene Mutation Database (HGMD): KIR2DS3
Locus Specific Mutation Databases (LSDB): KIR2DS3
| SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for KIR2DS3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KIR2DS3 for disorders About GeneDecksing
OMIM gene information: 604954
OMIM disorders: --
20/35  diseases for KIR2DS3 (see all 35): About MalaCardsvogt-koyanagi-harada disease birdshot chorioretinopathy tropical spastic paraparesis microscopic polyangiitis
graft versus host disease spastic paraparesis familial mediterranean fever non-hodgkin lymphoma
anterior uveitis spontaneous abortion ankylosing spondylitis systemic lupus erythematosus
lupus erythematosus hodgkin's lymphoma spasticity uveitis
spondylitis leptospirosis spondyloarthropathy behcet's disease
Genetic Association Database (GAD): KIR2DS3
Human Genome Epidemiology (HuGE) Navigator: KIR2DS3 (85 documents)
Export disorders for KIR2DS3 gene to outside databases
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Publications
for KIR2DS3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for KIR2DS3 gene, integrated from 9 sources (see all 93):
(articles sorted by number of sources associating them with KIR2DS3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Alternatively spliced forms of human killer inhibitory receptors. (PubMed id 8662091)1, 2, 3 Dohring C....Colonna M. (1996)
- Distribution of killer cell immunoglobulin-like receptor genes in the Chinese Han population. (PubMed id 15896204)1, 4 Jiang K....Yan L.X. (2005)
- Human diversity in killer cell inhibitory receptor genes. (PubMed id 9430221)1, 2 Uhrberg M.... Parham P. (1997)
- KIR genes polymorphism in Argentinean Caucasoid and Amerindian populations. (PubMed id 17498266)1, 9 Flores A.C....Fainboim L. (2007)
- Killer immunoglobulin-like receptor ligand HLA-Bw4 pr otects against multiple sclerosis. (PubMed id 19630074)1, 9 Lorentzen A.R....Harbo H.F. (2009)
- Association of killer cell immunoglobulin-like recepto rs with pulmonary tuberculosis in Chinese Han. (PubMed id 22653583)1 Lu C....Lu Z.M. (2012)
- A study of KIR genes and HLA-C in Vogt-Koyanagi-Harada disease in Saudi Arabia. (PubMed id 22219647)1 Sheereen A....Al-Hussein K. (2011)
- Innate immune genes synergize to predict increased ri sk of chronic disease in hepatitis C virus infection. (PubMed id 21402922)1 Dring M.M....Gardiner C.M. (2011)
- The beneficial impact of missing KIR ligands and abse nce of donor KIR2DS3 gene on outcome following unrelated hematopoietic SCT for myeloid leukemia in the Chinese population. (PubMed id 20173784)1 Wu G.Q....Huang H. (2010)
- HLA-DQA1*0505 sharing and Killer Immunoglobulin-like receptors in sub fertile couples: report of the 15th International Histocompati bility Workshop. (PubMed id 20210919)1 Varla-Leftherioti M....Spyropoulou-Vlachou M. (2010)
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External Searches for KIR2DS3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing KIR2DS3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing KIR2DS3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KIR2DS3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KIR2DS3 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for KIR2DS3 gene:
Search GeneIP for patents involving KIR2DS3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KIR2DS3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KIR2DS3 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIR2DS3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIR2DS3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIR2DS3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIR2DS3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIR2DS3 |
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