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Aliases for KIR2DS3 Gene

Aliases for KIR2DS3 Gene

  • Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Short Cytoplasmic Tail 3 2 3
  • Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short Cytoplasmic Tail, 3 2 3
  • Natural Killer-Associated Transcript 7 3 4
  • MHC Class I NK Cell Receptor 3 4
  • NKAT-7 3 4
  • NKAT7 3 4
  • Natural Killer Cell Inhibitory Receptor 3

External Ids for KIR2DS3 Gene

Previous GeneCards Identifiers for KIR2DS3 Gene

  • GC19P055480
  • GC19P9D0099
  • GC19P9F0099
  • GC00P9Q0098
  • GC19P9H0010
  • GC19P059933
  • GC19P9H0090
  • GC19P9I0099
  • GC19P9I0023
  • GC19P9I0100
  • GC19P055235
  • GC19U901482
  • GC19P8O0081

Summaries for KIR2DS3 Gene

Entrez Gene Summary for KIR2DS3 Gene

  • Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]

GeneCards Summary for KIR2DS3 Gene

KIR2DS3 (Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Short Cytoplasmic Tail 3) is a Protein Coding gene. Diseases associated with KIR2DS3 include microscopic polyangiitis and birdshot chorioretinopathy. Among its related pathways are Immune response Role of DAP12 receptors in NK cells and Allograft rejection.

UniProtKB/Swiss-Prot for KIR2DS3 Gene

  • Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIR2DS3 Gene

Genomics for KIR2DS3 Gene

Genomic Location for KIR2DS3 Gene

Chromosome:
19
Start:
150,177 bp from pter
End:
164,532 bp from pter
Size:
14,356 bases
Orientation:
Minus strand

Genomic View for KIR2DS3 Gene

Genes around KIR2DS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for KIR2DS3 Gene

No data available for Regulatory Elements for KIR2DS3 Gene

Proteins for KIR2DS3 Gene

  • Protein details for KIR2DS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14952-KI2S3_HUMAN
    Recommended name:
    Killer cell immunoglobulin-like receptor 2DS3
    Protein Accession:
    Q14952
    Secondary Accessions:
    • O00644

    Protein attributes for KIR2DS3 Gene

    Size:
    304 amino acids
    Molecular mass:
    33717 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KIR2DS3 Gene

Proteomics data for KIR2DS3 Gene at MOPED

Post-translational modifications for KIR2DS3 Gene

  • Glycosylation at Asn 67, Asn 84, and Asn 178
  • Modification sites at PhosphoSitePlus

Other Protein References for KIR2DS3 Gene

REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for KIR2DS3 Gene

Domains & Families for KIR2DS3 Gene

Protein Domains for KIR2DS3 Gene

Graphical View of Domain Structure for InterPro Entry

Q14952

UniProtKB/Swiss-Prot:

KI2S3_HUMAN :
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily.
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Family:
  • Belongs to the immunoglobulin superfamily.
genes like me logo Genes that share domains with KIR2DS3: view

Function for KIR2DS3 Gene

Molecular function for KIR2DS3 Gene

GENATLAS Biochemistry:
natural killer cell immunoglobulin-like activating receptor for HLA-C antigens,2DS3,with alternatively spliced (truncated) forms
UniProtKB/Swiss-Prot Function:
Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KIR2DS3 Gene

Localization for KIR2DS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIR2DS3 Gene

Cell membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for KIR2DS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 8765026
genes like me logo Genes that share ontologies with KIR2DS3: view

No data available for Subcellular locations from COMPARTMENTS for KIR2DS3 Gene

Pathways & Interactions for KIR2DS3 Gene

genes like me logo Genes that share pathways with KIR2DS3: view

Pathways by source for KIR2DS3 Gene

Interacting Proteins for KIR2DS3 Gene

Gene Ontology (GO) - Biological Process for KIR2DS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006968 cellular defense response TAS 8765026
genes like me logo Genes that share ontologies with KIR2DS3: view

No data available for SIGNOR curated interactions for KIR2DS3 Gene

Drugs & Compounds for KIR2DS3 Gene

No Compound Related Data Available

Transcripts for KIR2DS3 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for KIR2DS3 Gene

No ASD Table

Relevant External Links for KIR2DS3 Gene

GeneLoc Exon Structure for
KIR2DS3
ECgene alternative splicing isoforms for
KIR2DS3

Expression for KIR2DS3 Gene

mRNA expression in normal human tissues for KIR2DS3 Gene

Protein differential expression in normal tissues from HIPED for KIR2DS3 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KIR2DS3 Gene



genes like me logo Genes that share expression patterns with KIR2DS3: view

Protein tissue co-expression partners for KIR2DS3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KIR2DS3 Gene

Orthologs for KIR2DS3 Gene

No data available for Orthologs and Evolution for KIR2DS3 Gene

Paralogs for KIR2DS3 Gene

genes like me logo Genes that share paralogs with KIR2DS3: view

No data available for Paralogs for KIR2DS3 Gene

Variants for KIR2DS3 Gene

Relevant External Links for KIR2DS3 Gene

HapMap Linkage Disequilibrium report
KIR2DS3
Human Gene Mutation Database (HGMD)
KIR2DS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for KIR2DS3 Gene

Disorders for KIR2DS3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for KIR2DS3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
microscopic polyangiitis
  • mpa
birdshot chorioretinopathy
  • birdshot chorioretinitis
vogt-koyanagi-harada disease
  • harada's disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for KIR2DS3

Genetic Association Database (GAD)
KIR2DS3
Human Genome Epidemiology (HuGE) Navigator
KIR2DS3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIR2DS3
genes like me logo Genes that share disorders with KIR2DS3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIR2DS3 Gene

Publications for KIR2DS3 Gene

  1. Alternatively spliced forms of human killer inhibitory receptors. (PMID: 8662091) Doehring C. … Colonna M. (Immunogenetics 1996) 2 3 4 67
  2. Killer immunoglobulin-like receptor ligand HLA-Bw4 protects against multiple sclerosis. (PMID: 19630074) Lorentzen A.R. … Harbo H.F. (Ann. Neurol. 2009) 3 23
  3. KIR genes polymorphism in Argentinean Caucasoid and Amerindian populations. (PMID: 17498266) Flores A.C. … Fainboim L. (Tissue Antigens 2007) 3 23
  4. Killer-cell immunoglobulin-like receptors and falciparum malaria in southwest Nigeria. (PMID: 24929143) Olaniyan S.A. … Omotade O.O. (Hum. Immunol. 2014) 3
  5. Recombinant structures expand and contract inter and intragenic diversification at the KIR locus. (PMID: 23394822) Pyo C.W. … Geraghty D.E. (BMC Genomics 2013) 3

Products for KIR2DS3 Gene

Sources for KIR2DS3 Gene

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