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Aliases for KIR2DS3 Gene

Aliases for KIR2DS3 Gene

  • Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short Cytoplasmic Tail, 3 2 3
  • NKAT7 3 4 6
  • Natural Killer-Associated Transcript 7 3 4
  • MHC Class I NK Cell Receptor 3 4
  • NKAT-7 3 4
  • Killer Cell Immunoglobulin-Like Receptor 2DS3 3
  • Natural Killer Cell Inhibitory Receptor 3

External Ids for KIR2DS3 Gene

Summaries for KIR2DS3 Gene

Entrez Gene Summary for KIR2DS3 Gene

  • Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]

GeneCards Summary for KIR2DS3 Gene

KIR2DS3 (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short Cytoplasmic Tail, 3) is a Protein Coding gene. Diseases associated with KIR2DS3 include hematopoietic stem cell transplantation and microscopic polyangiitis. Among its related pathways are Signaling by FGFR and Class I MHC mediated antigen processing and presentation.

UniProtKB/Swiss-Prot for KIR2DS3 Gene

  • Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIR2DS3 Gene

Genomics for KIR2DS3 Gene

Genomic Location for KIR2DS3 Gene

Start:
81,218 bp from pter
End:
95,573 bp from pter
Size:
14,356 bases
Orientation:
Plus strand

Genomic View for KIR2DS3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:

RefSeq DNA sequence for KIR2DS3 Gene

No data available for Regulatory Elements for KIR2DS3 Gene

Proteins for KIR2DS3 Gene

  • Protein details for KIR2DS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14952-KI2S3_HUMAN
    Recommended name:
    Killer cell immunoglobulin-like receptor 2DS3
    Protein Accession:
    Q14952
    Secondary Accessions:
    • O00644

    Protein attributes for KIR2DS3 Gene

    Size:
    304 amino acids
    Molecular mass:
    33717 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KIR2DS3 Gene

Proteomics data for KIR2DS3 Gene at MOPED

Post-translational modifications for KIR2DS3 Gene

  • Glycosylation at Asn67, Asn84, and Asn178

Other Protein References for KIR2DS3 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for KIR2DS3 Gene

Domains for KIR2DS3 Gene

Gene Families for KIR2DS3 Gene

HGNC:
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • KIR :Killer cell immunoglobulin-like receptors

Protein Domains for KIR2DS3 Gene

Graphical View of Domain Structure for InterPro Entry

Q14952

UniProtKB/Swiss-Prot:

KI2S3_HUMAN
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.:
    • Q14952
Family:
  • Belongs to the immunoglobulin superfamily.:
    • Q14952
genes like me logo Genes that share domains with KIR2DS3: view

Function for KIR2DS3 Gene

Molecular function for KIR2DS3 Gene

GENATLAS Biochemistry: natural killer cell immunoglobulin-like activating receptor for HLA-C antigens,2DS3,with alternatively spliced (truncated) forms
UniProtKB/Swiss-Prot Function: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KIR2DS3 Gene

Localization for KIR2DS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIR2DS3 Gene

Cell membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for KIR2DS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 8765026
genes like me logo Genes that share ontologies with KIR2DS3: view

No data available for Subcellular locations from COMPARTMENTS for KIR2DS3 Gene

Pathways for KIR2DS3 Gene

genes like me logo Genes that share pathways with KIR2DS3: view

Interacting Proteins for KIR2DS3 Gene

Gene Ontology (GO) - Biological Process for KIR2DS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006968 cellular defense response TAS 8765026
genes like me logo Genes that share ontologies with KIR2DS3: view

Transcripts for KIR2DS3 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for KIR2DS3 Gene

No ASD Table

Relevant External Links for KIR2DS3 Gene

GeneLoc Exon Structure for
KIR2DS3
ECgene alternative splicing isoforms for
KIR2DS3

Expression for KIR2DS3 Gene

mRNA expression in normal human tissues for KIR2DS3 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for KIR2DS3 Gene

genes like me logo Genes that share expressions with KIR2DS3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KIR2DS3 Gene

Orthologs for KIR2DS3 Gene

No data available for Orthologs and Evolution for KIR2DS3 Gene

Paralogs for KIR2DS3 Gene

genes like me logo Genes that share paralogs with KIR2DS3: view

No data available for Paralogs for KIR2DS3 Gene

Variants for KIR2DS3 Gene

Relevant External Links for KIR2DS3 Gene

HapMap Linkage Disequilibrium report
KIR2DS3
Human Gene Mutation Database (HGMD)
KIR2DS3
Locus Specific Mutation Databases (LSDB)
KIR2DS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for KIR2DS3 Gene

Disorders for KIR2DS3 Gene

Relevant External Links for KIR2DS3

Genetic Association Database (GAD)
KIR2DS3
Human Genome Epidemiology (HuGE) Navigator
KIR2DS3
genes like me logo Genes that share disorders with KIR2DS3: view

No data available for UniProtKB/Swiss-Prot for KIR2DS3 Gene

Publications for KIR2DS3 Gene

  1. KIR genes polymorphism in Argentinean Caucasoid and Amerindian populations. (PMID: 17498266) Flores A.C. … Fainboim L. (Tissue Antigens 2007) 3 23 48
  2. Killer immunoglobulin-like receptor ligand HLA-Bw4 protects against multiple sclerosis. (PMID: 19630074) Lorentzen A.R. … Harbo H.F. (Ann. Neurol. 2009) 3 23 48
  3. Alternatively spliced forms of human killer inhibitory receptors. (PMID: 8662091) Doehring C. … Colonna M. (Immunogenetics 1996) 2 3 4
  4. Immunogenetic characteristics of patients with autoimmune gastritis. (PMID: 20082482) Oksanen A.M. … Partanen J.A. (World J. Gastroenterol. 2010) 3 48
  5. Association between killer-cell immunoglobulin-like receptor genotypes and leprosy in Brazil. (PMID: 18778326) Franceschi D.S. … Visentainer J.E. (Tissue Antigens 2008) 3 48

Products for KIR2DS3 Gene

Sources for KIR2DS3 Gene

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