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Aliases for KIR2DS2 Gene

Aliases for KIR2DS2 Gene

  • Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short Cytoplasmic Tail, 2 2 3
  • NKAT5 3 4 6
  • P58 Natural Killer Cell Receptor Clone CL-49 3 4
  • CD158 Antigen-Like Family Member J 3 4
  • MHC Class I NK Cell Receptor 3 4
  • NK Receptor 183 ActI 3 4
  • CD158J 3 4
  • NKAT-5 3 4
  • Killer-Cell Immunoglobulin-Like Receptor Two Domains Short Tail 2 Protein 3
  • Killer Cell Immunoglobulin-Like Receptor 2DS2 3
  • P58 Killer Cell Inhibitory Receptor KIR-K7a 3
  • Natural Killer Cell Inhibitory Receptor 3
  • Natural Killer Associated Transcript 5 3
  • Natural Killer-Associated Transcript 5 4
  • Killer-Cell Ig-Like Receptor 3
  • P58 NK Receptor CL-49 4
  • CD158j Antigen 4
  • 183ActI 3
  • CD158b 3
  • Cl-49 3

External Ids for KIR2DS2 Gene

Previous GeneCards Identifiers for KIR2DS2 Gene

  • GC19P055513
  • GC19P9D0131
  • GC19P9F0131
  • GC00P9Q0131
  • GC19P9H0009
  • GC19P9H0131
  • GC19P059936
  • GC19P9I0131
  • GC19U900901
  • GC19P055237
  • GC19P9W0464

Summaries for KIR2DS2 Gene

Entrez Gene Summary for KIR2DS2 Gene

  • Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene represents a haplotype-specific family member that encodes a protein with a short cytoplasmic tail. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for KIR2DS2 Gene

KIR2DS2 (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short Cytoplasmic Tail, 2) is a Protein Coding gene. Diseases associated with KIR2DS2 include birdshot chorioretinopathy and cytomegalovirus infection. Among its related pathways are Immune response Role of DAP12 receptors in NK cells and Immune response Role of DAP12 receptors in NK cells. GO annotations related to this gene include transmembrane signaling receptor activity.

UniProtKB/Swiss-Prot for KIR2DS2 Gene

  • Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIR2DS2 Gene

Genomics for KIR2DS2 Gene

Genomic Location for KIR2DS2 Gene

161,261 bp from pter
175,589 bp from pter
14,329 bases
Minus strand

Genomic View for KIR2DS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:

No data available for Regulatory Elements for KIR2DS2 Gene

Proteins for KIR2DS2 Gene

  • Protein details for KIR2DS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Killer cell immunoglobulin-like receptor 2DS2
    Protein Accession:
    Secondary Accessions:
    • Q14955
    • Q6H2G9

    Protein attributes for KIR2DS2 Gene

    304 amino acids
    Molecular mass:
    33502 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAC50338.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KIR2DS2 Gene

neXtProt entry for KIR2DS2 Gene

Proteomics data for KIR2DS2 Gene at MOPED

Post-translational modifications for KIR2DS2 Gene

  • Glycosylation at Asn84, Asn178, and Asn211
  • Modification sites at PhosphoSitePlus

Other Protein References for KIR2DS2 Gene

Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for KIR2DS2 Gene

Domains for KIR2DS2 Gene

Gene Families for KIR2DS2 Gene

  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • KIR :Killer cell immunoglobulin-like receptors

Protein Domains for KIR2DS2 Gene

Suggested Antigen Peptide Sequences for KIR2DS2 Gene

Graphical View of Domain Structure for InterPro Entry



  • P43631
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily.
genes like me logo Genes that share domains with KIR2DS2: view

Function for KIR2DS2 Gene

Molecular function for KIR2DS2 Gene

GENATLAS Biochemistry:
natural killer cell immunoglobulin-like activating receptor for HLA-C antigens,2DS2,with alternatively spliced (truncated) forms
UniProtKB/Swiss-Prot Function:
Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells

Gene Ontology (GO) - Molecular Function for KIR2DS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity NAS 8627176
genes like me logo Genes that share ontologies with KIR2DS2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KIR2DS2 Gene

Localization for KIR2DS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIR2DS2 Gene

Cell membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for KIR2DS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane NAS 8627176
genes like me logo Genes that share ontologies with KIR2DS2: view

No data available for Subcellular locations from COMPARTMENTS for KIR2DS2 Gene

Pathways for KIR2DS2 Gene

genes like me logo Genes that share pathways with KIR2DS2: view

Pathways by source for KIR2DS2 Gene

1 GeneGo (Thomson Reuters) pathway for KIR2DS2 Gene

Interacting Proteins for KIR2DS2 Gene

Selected Interacting proteins: P43631-KI2S2_HUMAN for KIR2DS2 Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for KIR2DS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response NAS 8627176
GO:0007165 signal transduction NAS 8627176
GO:0045087 innate immune response TAS --
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with KIR2DS2: view

Transcripts for KIR2DS2 Gene

mRNA/cDNA for KIR2DS2 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIR2DS2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIR2DS2 Gene

No ASD Table

Relevant External Links for KIR2DS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KIR2DS2 Gene

mRNA expression in normal human tissues for KIR2DS2 Gene

SOURCE GeneReport for Unigene cluster for KIR2DS2 Gene Hs.512572

genes like me logo Genes that share expressions with KIR2DS2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for KIR2DS2 Gene

Orthologs for KIR2DS2 Gene

No data available for Orthologs and Evolution for KIR2DS2 Gene

Paralogs for KIR2DS2 Gene

genes like me logo Genes that share paralogs with KIR2DS2: view

No data available for Paralogs for KIR2DS2 Gene

Variants for KIR2DS2 Gene

Sequence variations from dbSNP and Humsavar for KIR2DS2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
VAR_020090 -
VAR_059420 -
VAR_059421 -
VAR_059422 -

Relevant External Links for KIR2DS2 Gene

HapMap Linkage Disequilibrium report
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KIR2DS2 Gene

Disorders for KIR2DS2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for KIR2DS2 Gene in MalaCards »

(2) Diseases for KIR2DS2 Gene including...

Relevant External Links for KIR2DS2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with KIR2DS2: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for KIR2DS2 Gene

Publications for KIR2DS2 Gene

  1. Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. (PMID: 7716543) Colonna M. … Samaridis J. (Science 1995) 2 3 4
  2. Molecular clones of the p58 NK cell receptor reveal immunoglobulin- related molecules with diversity in both the extra- and intracellular domains. (PMID: 7749980) Wagtmann N. … Long E.O. (Immunity 1995) 2 3 4
  3. The human leukocyte antigen (HLA)-C-specific 'activatory' or 'inhibitory' natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions. (PMID: 8627176) Biassoni R. … Moretta L. (J. Exp. Med. 1996) 3 4
  4. Crystal structure of the human natural killer cell activating receptor KIR2DS2 (CD158j). (PMID: 12668644) Saulquin X. … Vivier E. (J. Exp. Med. 2003) 3 4
  5. KIR in type 1 diabetes: disparate distribution of activating and inhibitory natural killer cell receptors in patients versus HLA-matched control subjects. (PMID: 14514651) van der Slik A.R. … Giphart M.J. (Diabetes 2003) 3 48

Products for KIR2DS2 Gene

Sources for KIR2DS2 Gene

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