Aliases for KIR2DS2 Gene
Aliases for KIR2DS2 Gene
- Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Short Cytoplasmic Tail 2 2 3
- Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short Cytoplasmic Tail, 2 2 3
- P58 Natural Killer Cell Receptor Clone CL-49 3 4
- CD158 Antigen-Like Family Member J 3 4
- MHC Class I NK Cell Receptor 3 4
- NK Receptor 183 ActI 3 4
- CD158J 3 4
- NKAT-5 3 4
- NKAT5 3 4
- Killer-Cell Immunoglobulin-Like Receptor Two Domains Short Tail 2 Protein 3
- Killer Cell Immunoglobulin-Like Receptor KIR2DS2 3
- Killer Cell Immunoglobulin-Like Receptor 2DS2 3
Previous GeneCards Identifiers for KIR2DS2 Gene
- GC19P055513
- GC19P9D0131
- GC19P9F0131
- GC00P9Q0131
- GC19P9H0009
- GC19P9H0131
- GC19P059936
- GC19P9I0131
- GC19U900901
- GC19P055237
- GC19P9W0464
- GC19M8U0161
- GC19Pk00721
Summaries for KIR2DS2 Gene
-
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene represents a haplotype-specific family member that encodes a protein with a short cytoplasmic tail. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
GeneCards Summary for KIR2DS2 Gene
KIR2DS2 (Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Short Cytoplasmic Tail 2) is a Protein Coding gene. Diseases associated with KIR2DS2 include Birdshot Chorioretinopathy. Among its related pathways are Innate Immune System and Immune response Role of DAP12 receptors in NK cells. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity.
UniProtKB/Swiss-Prot for KIR2DS2 Gene
-
Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.
Additional gene information for KIR2DS2 Gene
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIR2DS2 Gene
Genomics for KIR2DS2 Gene
Regulatory Element Products
Genomic Locations for KIR2DS2 Gene
- chr19:194,387-208,698
- (GRCh38/hg38)
- Size:
- 14,312 bases
- Orientation:
- Minus strand
Genomic View for KIR2DS2 Gene
- Cytogenetic band:
-
- 19q13.4 by Entrez Gene
- 19q13.4 alternate reference locus by HGNC

RefSeq DNA sequence for KIR2DS2 Gene
No data available for GeneHancer (GH) Regulatory Elements for KIR2DS2 Gene
Proteins for KIR2DS2 Gene
-
Protein details for KIR2DS2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P43631-KI2S2_HUMAN
- Recommended name:
- Killer cell immunoglobulin-like receptor 2DS2
- Protein Accession:
- P43631
- Q14955
- Q6H2G9
Protein attributes for KIR2DS2 Gene
- Size:
- 304 amino acids
- Molecular mass:
- 33502 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAC50338.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Post-translational modifications for KIR2DS2 Gene
- Glycosylation at isoforms=84, posLast=178178, and posLast=211211
Other Protein References for KIR2DS2 Gene
- REFSEQ proteins:
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No data available for DME Specific Peptides for KIR2DS2 Gene
Domains & Families for KIR2DS2 Gene
Gene Families for KIR2DS2 Gene
Protein Domains for KIR2DS2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for KIR2DS2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P43631- Family:
-
- Belongs to the immunoglobulin superfamily.
Function for KIR2DS2 Gene
Molecular function for KIR2DS2 Gene
- GENATLAS Biochemistry:
- natural killer cell immunoglobulin-like activating receptor for HLA-C antigens,2DS2,with alternatively spliced (truncated) forms
- UniProtKB/Swiss-Prot Function:
- Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004888 | transmembrane signaling receptor activity | NAS | 8627176 |
Phenotypes for KIR2DS2 Gene
- GenomeRNAi human phenotypes for KIR2DS2:
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- Mammalian expression: PiggyBac
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- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
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No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KIR2DS2 Gene
Localization for KIR2DS2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for KIR2DS2 Gene
- Cell membrane; Single-pass type I membrane protein.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016021 | integral component of membrane | NAS | 8627176 |
No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for KIR2DS2 Gene
Pathways & Interactions for KIR2DS2 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Immune response Role of DAP12 receptors in NK cells | ||
2 | Innate Immune System |
.61
|
|
3 | Allograft rejection | ||
4 | Class I MHC mediated antigen processing and presentation | ||
5 | RET signaling |
Pathways by source for KIR2DS2 Gene
5 Reactome pathways for KIR2DS2 Gene
2 KEGG pathways for KIR2DS2 Gene
1 GeneGo (Thomson Reuters) pathway for KIR2DS2 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006955 | immune response | NAS | 8627176 |
GO:0007165 | signal transduction | IEA | -- |
GO:0045087 | innate immune response | TAS | -- |
GO:0050776 | regulation of immune response | TAS | -- |
No data available for SIGNOR curated interactions for KIR2DS2 Gene
Transcripts for KIR2DS2 Gene
mRNA/cDNA for KIR2DS2 Gene
- (6) REFSEQ mRNAs :
CRISPR Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
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-
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Expression for KIR2DS2 Gene
NURSA nuclear receptor signaling pathways regulating expression of KIR2DS2 Gene:
KIR2DS2SOURCE GeneReport for Unigene cluster for KIR2DS2 Gene:
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No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIR2DS2 Gene
Orthologs for KIR2DS2 Gene
No data available for Orthologs and Evolution for KIR2DS2 Gene
Paralogs for KIR2DS2 Gene
(55) SIMAP similar genes for KIR2DS2 Gene using alignment to 10 proteins:
- KIR2DS2S3
- KIR-K36
- KIR412
- KIR2DS1
- KIR-K9
- KIR-K78
- KIR-K65
- KIR-K3
- KIR2DL3
- p58
- KIR-K61
- KIR2DL2
- KIR2DS3
- KIR2DS5
- KIR-K64
- KIR-K15
- KIR2DS4
- KIR2DS
- KIR411
- KIR2DL1
- KIR2DP1DL1
- KIR-K39
- KIR-G1
- KIR222
- KIR-123FM
- KIR3DS1
- KIR221
- KIR3DP1
- KIR3DSL1
- KIR3DL2
- kir3d
- KIR3DL1/2V
- KIR3DL1
- KIR-G2
- KIR3DL3
- KIR2DL5B
- KIR2DLX
- KIR2DL5A
- KIR2DL4
- LILRA6
- LILRA1
- LILRB3
- LILRA3
- LILRB1
- KIR3DX1
- FLJ00275
- LILRA2
- LILRA4
- NKAT2a-delta-Ig2
- LILRB5
- LILRB2
- MIR cl-10
- p140
- LILRA5
- GP6
No data available for Paralogs for KIR2DS2 Gene
Variants for KIR2DS2 Gene
Additional Variant Information for KIR2DS2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- KIR2DS2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for KIR2DS2 Gene
Disorders for KIR2DS2 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
birdshot chorioretinopathy |
|
|
Additional Disease Information for KIR2DS2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for KIR2DS2 Gene
Publications for KIR2DS2 Gene
- Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. (PMID: 7716543) Colonna M … Samaridis J (Science (New York, N.Y.) 1995) 2 3 4 58
- Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains. (PMID: 7749980) Wagtmann N … Long EO (Immunity 1995) 2 3 4 58
- Association of KIR2DS1 and KIR2DS3 with fatal outcome in Ebola virus infection. (PMID: 20878400) Wauquier N … Vieillard V (Immunogenetics 2010) 3 44 58
- Inhibitory KIR and specific HLA-C gene combinations confer susceptibility to or protection against chronic hepatitis B. (PMID: 20643584) Gao X … Zhao Y (Clinical immunology (Orlando, Fla.) 2010) 3 44 58
- Association of killer cell immunoglobulin-like receptors and human leukocyte antigen-C genotypes in South Brazilian with type 1 diabetes. (PMID: 20580654) Jobim M … Schwartsmann G (Human immunology 2010) 3 44 58
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
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Sources for KIR2DS2 Gene
- (1) GeneCards
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