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Aliases for KIR2DS2 Gene

Aliases for KIR2DS2 Gene

  • Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Short Cytoplasmic Tail 2 2 3
  • Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short Cytoplasmic Tail, 2 2 3
  • P58 Natural Killer Cell Receptor Clone CL-49 3 4
  • CD158 Antigen-Like Family Member J 3 4
  • MHC Class I NK Cell Receptor 3 4
  • NK Receptor 183 ActI 3 4
  • CD158J 3 4
  • NKAT-5 3 4
  • NKAT5 3 4
  • Killer-Cell Immunoglobulin-Like Receptor Two Domains Short Tail 2 Protein 3
  • P58 Killer Cell Inhibitory Receptor KIR-K7a 3
  • Natural Killer Cell Inhibitory Receptor 3
  • Natural Killer Associated Transcript 5 3
  • Natural Killer-Associated Transcript 5 4
  • Killer-Cell Ig-Like Receptor 3
  • P58 NK Receptor CL-49 4
  • CD158j Antigen 4
  • KIR-2DS2 3
  • 183ActI 3
  • CD158b 3
  • Cl-49 3

External Ids for KIR2DS2 Gene

Previous GeneCards Identifiers for KIR2DS2 Gene

  • GC19P055513
  • GC19P9D0131
  • GC19P9F0131
  • GC00P9Q0131
  • GC19P9H0009
  • GC19P9H0131
  • GC19P059936
  • GC19P9I0131
  • GC19U900901
  • GC19P055237
  • GC19P9W0464
  • GC19M8U0161
  • GC19Pk00721

Summaries for KIR2DS2 Gene

Entrez Gene Summary for KIR2DS2 Gene

  • Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene represents a haplotype-specific family member that encodes a protein with a short cytoplasmic tail. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for KIR2DS2 Gene

KIR2DS2 (Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Short Cytoplasmic Tail 2) is a Protein Coding gene. Diseases associated with KIR2DS2 include Birdshot Chorioretinopathy. Among its related pathways are Natural Killer Cell Receptors: Human Target Cell ?�� NK Cell Ligand-Receptor Interactions and Immune System. GO annotations related to this gene include transmembrane signaling receptor activity.

UniProtKB/Swiss-Prot for KIR2DS2 Gene

  • Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIR2DS2 Gene

Genomics for KIR2DS2 Gene

Regulatory Elements for KIR2DS2 Gene

Enhancers for KIR2DS2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KIR2DS2 on UCSC Golden Path with GeneCards custom track

Genomic Location for KIR2DS2 Gene

Chromosome:
19
Start:
194,387 bp from pter
End:
208,698 bp from pter
Size:
14,312 bases
Orientation:
Minus strand

Genomic View for KIR2DS2 Gene

Genes around KIR2DS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GeneLoc Logo Gene Density

Proteins for KIR2DS2 Gene

  • Protein details for KIR2DS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43631-KI2S2_HUMAN
    Recommended name:
    Killer cell immunoglobulin-like receptor 2DS2
    Protein Accession:
    P43631
    Secondary Accessions:
    • Q14955
    • Q6H2G9

    Protein attributes for KIR2DS2 Gene

    Size:
    304 amino acids
    Molecular mass:
    33502 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC50338.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KIR2DS2 Gene

neXtProt entry for KIR2DS2 Gene

Proteomics data for KIR2DS2 Gene at MOPED

Post-translational modifications for KIR2DS2 Gene

  • Glycosylation at Asn 84, Asn 178, and Asn 211
  • Modification sites at PhosphoSitePlus

Other Protein References for KIR2DS2 Gene

Antibody Products

No data available for DME Specific Peptides for KIR2DS2 Gene

Domains & Families for KIR2DS2 Gene

Protein Domains for KIR2DS2 Gene

Suggested Antigen Peptide Sequences for KIR2DS2 Gene

Graphical View of Domain Structure for InterPro Entry

P43631

UniProtKB/Swiss-Prot:

KI2S2_HUMAN :
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily.
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Family:
  • Belongs to the immunoglobulin superfamily.
genes like me logo Genes that share domains with KIR2DS2: view

Function for KIR2DS2 Gene

Molecular function for KIR2DS2 Gene

GENATLAS Biochemistry:
natural killer cell immunoglobulin-like activating receptor for HLA-C antigens,2DS2,with alternatively spliced (truncated) forms
UniProtKB/Swiss-Prot Function:
Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.

Gene Ontology (GO) - Molecular Function for KIR2DS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity NAS 8627176
genes like me logo Genes that share ontologies with KIR2DS2: view
genes like me logo Genes that share phenotypes with KIR2DS2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KIR2DS2 Gene

Localization for KIR2DS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIR2DS2 Gene

Cell membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for KIR2DS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane NAS 8627176
genes like me logo Genes that share ontologies with KIR2DS2: view

No data available for Subcellular locations from COMPARTMENTS for KIR2DS2 Gene

Pathways & Interactions for KIR2DS2 Gene

genes like me logo Genes that share pathways with KIR2DS2: view

Interacting Proteins for KIR2DS2 Gene

Selected Interacting proteins: P43631-KI2S2_HUMAN for KIR2DS2 Gene via I2D

Symbol External ID(s) Details
HLA-C
TYROBP

Gene Ontology (GO) - Biological Process for KIR2DS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response NAS 8627176
GO:0007165 signal transduction NAS 8627176
GO:0045087 innate immune response TAS --
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with KIR2DS2: view

No data available for SIGNOR curated interactions for KIR2DS2 Gene

Drugs & Compounds for KIR2DS2 Gene

No Compound Related Data Available

Transcripts for KIR2DS2 Gene

mRNA/cDNA for KIR2DS2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for KIR2DS2 Gene

No ASD Table

Relevant External Links for KIR2DS2 Gene

GeneLoc Exon Structure for
KIR2DS2
ECgene alternative splicing isoforms for
KIR2DS2

Expression for KIR2DS2 Gene

mRNA expression in normal human tissues for KIR2DS2 Gene

SOURCE GeneReport for Unigene cluster for KIR2DS2 Gene Hs.512572

genes like me logo Genes that share expression patterns with KIR2DS2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for KIR2DS2 Gene

Orthologs for KIR2DS2 Gene

No data available for Orthologs and Evolution for KIR2DS2 Gene

Paralogs for KIR2DS2 Gene

genes like me logo Genes that share paralogs with KIR2DS2: view

No data available for Paralogs for KIR2DS2 Gene

Variants for KIR2DS2 Gene

Sequence variations from dbSNP and Humsavar for KIR2DS2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_020090 -
VAR_059420 -
VAR_059421 -
VAR_059422 -

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Relevant External Links for KIR2DS2 Gene

Disorders for KIR2DS2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KIR2DS2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
birdshot chorioretinopathy
  • birdshot chorioretinitis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for KIR2DS2

Genetic Association Database (GAD)
KIR2DS2
Human Genome Epidemiology (HuGE) Navigator
KIR2DS2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIR2DS2
genes like me logo Genes that share disorders with KIR2DS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIR2DS2 Gene

Publications for KIR2DS2 Gene

  1. Molecular clones of the p58 NK cell receptor reveal immunoglobulin- related molecules with diversity in both the extra- and intracellular domains. (PMID: 7749980) Wagtmann N. … Long E.O. (Immunity 1995) 2 3 4 67
  2. Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. (PMID: 7716543) Colonna M. … Samaridis J. (Science 1995) 2 3
  3. Killer cell immunoglobulin receptor profile on CD4(+) A CD28(-) T cells and their pathogenic role in non-dialysis-dependent and dialysis-dependent chronic kidney disease patients. (PMID: 25484131) Zal B. … Baboonian C. (Immunology 2015) 3
  4. [Correlation analysis between killer cell immunoglobulin-like receptor gene polymorphism and primary biliary cirrhosis]. (PMID: 25575065) Zheng L. … Wang Y. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2015) 3
  5. Contribution of genes for killer cell immunoglobulin-like receptors (KIR) to the susceptibility to chronic hepatitis C virus infection and to viremia. (PMID: 25636579) KuA9nierczyk P. … A>eromski J. (Hum. Immunol. 2015) 3

Products for KIR2DS2 Gene

Sources for KIR2DS2 Gene

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