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Aliases for KIR2DL5B Gene

Aliases for KIR2DL5B Gene

  • Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 5B 2 3
  • Killer Cell Immunoglobulin-Like Receptor 2DLX 3 4
  • CD158 Antigen-Like Family Member F2 3 4
  • KIR2DL5 3 4
  • KIR2DLX 3 4
  • Killer Cell Immunoglobulin-Like Receptor 2DL5B 3
  • Killer Cell Ig-Like Receptor 3
  • CD158f2 Antigen 4
  • KIR2DL5.2 3
  • CD158F2 4
  • CD158F 4

External Ids for KIR2DL5B Gene

Previous GeneCards Identifiers for KIR2DL5B Gene

  • GC19P9H0087
  • GC19U900568
  • GC19P9I0087
  • GC19P9I0088
  • GC19P9I0089
  • GC19P9I0090
  • GC19P9J0007

Summaries for KIR2DL5B Gene

Entrez Gene Summary for KIR2DL5B Gene

  • Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]

GeneCards Summary for KIR2DL5B Gene

KIR2DL5B (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 5B) is a Protein Coding gene.

UniProtKB/Swiss-Prot for KIR2DL5B Gene

  • Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIR2DL5B Gene

Genomics for KIR2DL5B Gene

Genomic Location for KIR2DL5B Gene

133,293 bp from pter
142,813 bp from pter
9,521 bases
Minus strand

Genomic View for KIR2DL5B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:

RefSeq DNA sequence for KIR2DL5B Gene

No data available for Regulatory Elements for KIR2DL5B Gene

Proteins for KIR2DL5B Gene

  • Protein details for KIR2DL5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Killer cell immunoglobulin-like receptor 2DL5B
    Protein Accession:
    Secondary Accessions:

    Protein attributes for KIR2DL5B Gene

    375 amino acids
    Molecular mass:
    40607 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KIR2DL5B Gene

Proteomics data for KIR2DL5B Gene at MOPED

Post-translational modifications for KIR2DL5B Gene

  • Glycosylation at Asn218
  • Modification sites at PhosphoSitePlus

Other Protein References for KIR2DL5B Gene

REFSEQ proteins:

No data available for DME Specific Peptides for KIR2DL5B Gene

Domains for KIR2DL5B Gene

Gene Families for KIR2DL5B Gene

  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • KIR :Killer cell immunoglobulin-like receptors

Protein Domains for KIR2DL5B Gene

Suggested Antigen Peptide Sequences for KIR2DL5B Gene

Graphical View of Domain Structure for InterPro Entry



  • Q8NHK3
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily.
genes like me logo Genes that share domains with KIR2DL5B: view

Function for KIR2DL5B Gene

Molecular function for KIR2DL5B Gene

UniProtKB/Swiss-Prot Function: Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KIR2DL5B Gene

Localization for KIR2DL5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIR2DL5B Gene

Cell membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for KIR2DL5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KIR2DL5B: view

No data available for Subcellular locations from COMPARTMENTS for KIR2DL5B Gene

Pathways for KIR2DL5B Gene

SuperPathways for KIR2DL5B Gene

No Data Available

Interacting Proteins for KIR2DL5B Gene

Gene Ontology (GO) - Biological Process for KIR2DL5B Gene


No data available for Pathways by source for KIR2DL5B Gene

Transcripts for KIR2DL5B Gene

mRNA/cDNA for KIR2DL5B Gene

(1) REFSEQ mRNAs :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIR2DL5B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KIR2DL5B
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIR2DL5B Gene

No ASD Table

Relevant External Links for KIR2DL5B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KIR2DL5B Gene

mRNA expression in normal human tissues for KIR2DL5B Gene

genes like me logo Genes that share expressions with KIR2DL5B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for KIR2DL5B Gene

Orthologs for KIR2DL5B Gene

No data available for Orthologs and Evolution for KIR2DL5B Gene

Paralogs for KIR2DL5B Gene

genes like me logo Genes that share paralogs with KIR2DL5B: view

No data available for Paralogs for KIR2DL5B Gene

Variants for KIR2DL5B Gene

Relevant External Links for KIR2DL5B Gene

HapMap Linkage Disequilibrium report
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for KIR2DL5B Gene

Disorders for KIR2DL5B Gene

Relevant External Links for KIR2DL5B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with KIR2DL5B: view

No data available for UniProtKB/Swiss-Prot for KIR2DL5B Gene

Publications for KIR2DL5B Gene

  1. Some human KIR haplotypes contain two KIR2DL5 genes: KIR2DL5A and KIR2DL5B. (PMID: 12185535) Gomez-Lozano N. … Vilches C. (Immunogenetics 2002) 2 3 4 23
  2. Gene structure and promoter variation of expressed and nonexpressed variants of the KIR2DL5 gene. (PMID: 11086080) Vilches C. … Parham P. (J. Immunol. 2000) 2 3 23
  3. Association of KIR2DS1 and KIR2DS3 with fatal outcome in Ebola virus infection. (PMID: 20878400) Wauquier N. … Vieillard V. (Immunogenetics 2010) 3 48
  4. [Polymorphism of killer cell immunoglobulin-like receptors gene family in Zhejiang Han population]. (PMID: 16403292) Zhu F.M. … Yan L.X. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2005) 3 48
  5. Association of KIR2DL5B gene with celiac disease supports the susceptibility locus on 19q13.4. (PMID: 17215859) Santin I. … Bilbao J.R. (Genes Immun. 2007) 3 48

Products for KIR2DL5B Gene

Sources for KIR2DL5B Gene

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