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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KIR2DL5B Gene

protein-coding   GIFtS: 28
GCID: GC19U900568

Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic
Tail, 5B1 2
     Killer Cell Ig-Like Receptor2
Killer Cell Immunoglobulin-Like Receptor 2DLX2 3     Killer Cell Immunoglobulin-Like Receptor 2DL5B2
KIR2DL52 3     CD158F3
KIR2DLX2 3     CD158F23
CD158 Antigen-Like Family Member F22 3     CD158f2 Antigen3
KIR2DL5.22     

External Ids:    HGNC: 163461   Entrez Gene: 5531282   UniProtKB: Q8NHK33   

Export aliases for KIR2DL5B gene to outside databases

Previous GC identifers: GC19P9H0087 GC19P9I0087 GC19P9I0088 GC19P9I0089 GC19P9I0090 GC19P9J0007


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KIR2DL5B Gene:
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells
and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on
chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster
varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1,
KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or
3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic
domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM),
while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO
protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are
subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the
immune response. (provided by RefSeq, Jul 2008)

GeneCards Summary for KIR2DL5B Gene: 
KIR2DL5B (killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5B) is a protein-coding gene. Diseases associated with KIR2DL5B include leptospirosis, and celiac disease.

UniProtKB/Swiss-Prot: KI2LB_HUMAN, Q8NHK3
Function: Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus
preventing cell lysis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for KIR2DL5B
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Epigenetics:
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Genomic Location:
Chromosome:19   

Entrez Gene cytogenetic band: 19p13.3   HGNC cytogenetic band: 19q13.4

GeneLoc information about chromosome 19        


(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KI2LB_HUMAN, Q8NHK3 (See protein sequence)
Recommended Name: Killer cell immunoglobulin-like receptor 2DL5B precursor  
Size: 375 amino acids; 40607 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein

Explore the universe of human proteins at neXtProt for KIR2DL5B: NX_Q8NHK3

KIR2DL5B Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

REFSEQ proteins: NP_001018091.1  
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane IEA--
GO:0016021integral to membrane IEA--

KIR2DL5B for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
KIR: Killer cell immunoglobulin-like receptors
IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

3 InterPro protein domains:
 IPR003599 Ig_sub
 IPR013783 Ig-like_fold
 IPR013151 Immunoglobulin

Graphical View of Domain Structure for InterPro Entry Q8NHK3

ProtoNet protein and cluster: Q8NHK3

UniProtKB/Swiss-Prot: KI2LB_HUMAN, Q8NHK3
Similarity: Belongs to the immunoglobulin superfamily
Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


KIR2DL5B for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: KI2LB_HUMAN, Q8NHK3
Function: Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus
preventing cell lysis

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIR2DL5B

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for KIR2DL5B gene: 
NM_001018081.1  

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(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KIR2DL5B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
KIR2DL5B Expression
About this image


Genevestigator expression for KIR2DL5B
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
  --

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for KIR2DL5B gene
18/45 SIMAP similar genes for KIR2DL5B using alignment to 5 protein entries:     KI2LB_HUMAN (see all proteins) (see all similar genes):
KIR2DL5A    KIR2DLX    KIR411    KIR2DL4    KIR-G1    KIR221
KIR-G2    p140    KIR2DL2    KIR2DP1DL1    KIR2DL3    KIR2DL1
NKAT2a-delta-Ig2    KIR2DS2    KIR2DS2S3    KIR2DS1    KIR2DS5    KIR2DS3

KIR2DL5B for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

Locus Specific Mutation Databases (LSDB): KIR2DL5B
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing KIR2DL5B
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
5 diseases for KIR2DL5B:    About MalaCards
leptospirosis    celiac disease    nasopharyngitis    influenza
leukemia


KIR2DL5B for disorders           About GeneDecksing

Genetic Association Database (GAD): KIR2DL5B
Human Genome Epidemiology (HuGE) Navigator: KIR2DL5B (16 documents)

Export disorders for KIR2DL5B gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for KIR2DL5B gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with KIR2DL5B)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Some human KIR haplotypes contain two KIR2DL5 genes: KIR2DL5A and KIR2DL5B. (PubMed id 12185535)1, 2, 3, 9 Gomez-Lozano N.... Vilches C. (2002)
  2. Gene structure and promoter variation of expressed and nonexpressed variants of the KIR2DL5 gene. (PubMed id 11086080)1, 3, 9 Vilches C.... Parham P. (2000)
  3. Association of KIR2DS1 and KIR2DS3 with fatal outcome in Ebola virus infection. (PubMed id 20878400)1, 4 Wauquier N....Vieillard V. (2010)
  4. Killer cell immunoglobulin-like receptor gene polymor phisms in patients with leukemia: possible association with susceptibility to t he disease. (PubMed id 19450876)1, 4 Zhang Y....Qi J. (2010)
  5. [Analysis of natural killer cell immunoglobulin-like receptor genes in Chinese] (PubMed id 19218127)1, 4 Fu S.J....Deng W.F. (2009)
  6. Distribution of killer-cell immunoglobulin-like recep tor genes in Eastern mainland Chinese Han and Taiwanese Han populations. (PubMed id 19761533)1, 4 Wu G.Q....Huang H. (2009)
  7. Role of human leukocyte antigen, killer-cell immunogl obulin-like receptors, and cytokine gene polymorphisms in leptospirosis. (PubMed id 19683555)1, 4 Fialho R.N....Bruges-Armas J. (2009)
  8. Different KIRs confer susceptibility and protection to adults with latent autoimmune diabetes in Latvian and Asian Indian populations. (PubMed id 19120281)1, 4 Shastry A....Sanjeevi C.B. (2008)
  9. Association of KIR2DL5B gene with celiac disease supports the susceptibility locus on 19q13.4. (PubMed id 17215859)1, 4 Santin I....Bilbao J.R. (2007)
  10. [Polymorphism of killer cell immunoglobulin-like receptors gene family in Zhejiang Han population] (PubMed id 16403292)1, 4 Zhu F.M....Yan L.X. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
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  Query String
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 553128 HGNC: 16346 euGenes: HUgn553128 ECgene: KIR2DL5B H-InvDB: KIR2DL5B

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for KIR2DL5B Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for KIR2DL5B gene:
Search GeneIP for patents involving KIR2DL5B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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 LSBio Antibodies in human, mouse, rat for KIR2DL5B
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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(GIFtS: 73)
transforming growth factor, beta 1
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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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