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KIR2DL5B Gene

protein-coding   GIFtS: 28
GCID: GC19U900568

Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long...

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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic
Tail, 5B1 2
     Killer Cell Ig-Like Receptor2
Killer Cell Immunoglobulin-Like Receptor 2DLX2 3     Killer Cell Immunoglobulin-Like Receptor 2DL5B2
KIR2DL52 3     CD158F3
KIR2DLX2 3     CD158F23
CD158 Antigen-Like Family Member F22 3     CD158f2 Antigen3
KIR2DL5.22     

External Ids:    HGNC: 163461   Entrez Gene: 5531282   UniProtKB: Q8NHK33   

Export aliases for KIR2DL5B gene to outside databases

Previous GC identifers: GC19P9H0087 GC19P9I0087 GC19P9I0088 GC19P9I0089 GC19P9I0090 GC19P9J0007


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KIR2DL5B Gene:
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells
and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on
chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster
varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1,
KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or
3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic
domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM),
while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO
protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are
subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the
immune response. (provided by RefSeq, Jul 2008)

GeneCards Summary for KIR2DL5B Gene:
KIR2DL5B (killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5B) is a protein-coding gene. Diseases associated with KIR2DL5B include leptospirosis, and celiac disease.

UniProtKB/Swiss-Prot: KI2LB_HUMAN, Q8NHK3
Function: Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus
preventing cell lysis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for KIR2DL5B
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KIR2DL5B


Genomic Location:
Chromosome:19   

Entrez Gene cytogenetic band: 19p13.3   HGNC cytogenetic band: 19q13.4 alternate reference locus

GeneLoc information about chromosome 19        


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
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UniProtKB/Swiss-Prot: KI2LB_HUMAN, Q8NHK3 (See protein sequence)
Recommended Name: Killer cell immunoglobulin-like receptor 2DL5B precursor  
Size: 375 amino acids; 40607 Da

Explore the universe of human proteins at neXtProt for KIR2DL5B: NX_Q8NHK3

Post-translational modifications: 

  • Glycosylation2 at Asn218
  • REFSEQ proteins: NP_001018091.1  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KIR: Killer cell immunoglobulin-like receptors
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    3 InterPro protein domains:
     IPR003599 Ig_sub
     IPR013783 Ig-like_fold
     IPR013151 Immunoglobulin

    Graphical View of Domain Structure for InterPro Entry Q8NHK3

    ProtoNet protein and cluster: Q8NHK3

    UniProtKB/Swiss-Prot: KI2LB_HUMAN, Q8NHK3
    Similarity: Belongs to the immunoglobulin superfamily
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


    KIR2DL5B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KI2LB_HUMAN, Q8NHK3
    Function: Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus
    preventing cell lysis

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KI2LB_HUMAN, Q8NHK3: Cell membrane; Single-pass type I membrane protein

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    KIR2DL5B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Tocris compounds for KIR2DL5B (KI2LB)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KIR2DL5B gene: 
    NM_001018081.1  

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    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KIR2DL5B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KIR2DL5B Expression
    About this image

    KIR2DL5B Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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      --

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KIR2DL5B gene
    Selected SIMAP similar genes for KIR2DL5B using alignment to 5 protein entries:     KI2LB_HUMAN (see all proteins) (see all similar genes):
    KIR2DL5A    KIR2DLX    KIR411    KIR2DL4    KIR-G1    KIR221
    KIR-G2    p140    KIR2DL2    KIR2DL3    KIR2DP1DL1    KIR2DL1
    NKAT2a-delta-Ig2    KIR2DS2    KIR2DS2S3    KIR2DS1    KIR2DS5    KIR2DS3

    KIR2DL5B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Locus Specific Mutation Databases (LSDB): KIR2DL5B

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    6 diseases for KIR2DL5B:    
    About MalaCards
    leptospirosis    celiac disease    nasopharyngitis    influenza
    hiv-1    leukemia


    KIR2DL5B for disorders           About GeneDecksing

    Genetic Association Database (GAD): KIR2DL5B
    Human Genome Epidemiology (HuGE) Navigator: KIR2DL5B (16 documents)

    Export disorders for KIR2DL5B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KIR2DL5B gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with KIR2DL5B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Some human KIR haplotypes contain two KIR2DL5 genes: KIR2DL5A and KIR2DL5B. (PubMed id 12185535)1, 2, 3, 9 Gomez-Lozano N.... Vilches C. (Immunogenetics 2002)
    2. Gene structure and promoter variation of expressed and nonexpressed variants of the KIR2DL5 gene. (PubMed id 11086080)1, 3, 9 Vilches C.... Parham P. (J. Immunol. 2000)
    3. Association of KIR2DS1 and KIR2DS3 with fatal outcome in Ebola virus infection. (PubMed id 20878400)1, 4 Wauquier N....Vieillard V. (Immunogenetics 2010)
    4. Killer cell immunoglobulin-like receptor gene polymorphisms in patients with leukemia: possible association with susceptibility to the disease. (PubMed id 19450876)1, 4 Zhang Y....Qi J. (Leuk. Res. 2010)
    5. [Analysis of natural killer cell immunoglobulin-like receptor genes in Chinese]. (PubMed id 19218127)1, 4 Fu S.J....Deng W.F. (Nan Fang Yi Ke Da Xue Xue Bao 2009)
    6. Distribution of killer-cell immunoglobulin-like receptor genes in Eastern mainland Chinese Han and Taiwanese Han populations. (PubMed id 19761533)1, 4 Wu G.Q....Huang H. (Tissue Antigens 2009)
    7. Role of human leukocyte antigen, killer-cell immunoglobulin-like receptors, and cytokine gene polymorphisms in leptospirosis. (PubMed id 19683555)1, 4 Fialho R.N....Bruges-Armas J. (Hum. Immunol. 2009)
    8. Different KIRs confer susceptibility and protection to adults with latent autoimmune diabetes in Latvian and Asian Indian populations. (PubMed id 19120281)1, 4 Shastry A....Sanjeevi C.B. (Ann. N. Y. Acad. Sci. 2008)
    9. Association of KIR2DL5B gene with celiac disease supports the susceptibility locus on 19q13.4. (PubMed id 17215859)1, 4 Santin I....Bilbao J.R. (Genes Immun. 2007)
    10. [Polymorphism of killer cell immunoglobulin-like receptors gene family in Zhejiang Han population]. (PubMed id 16403292)1, 4 Zhu F.M....Yan L.X. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 553128 HGNC: 16346 euGenes: HUgn553128 ECgene: KIR2DL5B H-InvDB: KIR2DL5B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KIR2DL5B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KIR2DL5B gene:
    Search GeneIP for patents involving KIR2DL5B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIR2DL5B
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KIR2DL5B
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KIR2DL5B
     LSBio Antibodies in human, mouse, rat for KIR2DL5B
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