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KIR2DL4 Gene

protein-coding   GIFtS: 61
GCID: GC19P055276

Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long...

  See KIR2DL4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic
Tail, 41 2
     MHC Class I NK Cell Receptor KIR103AS2 3
KIR103AS2 3 5     KIR1032
Killer Cell Inhibitory Receptor 103AS2 3     Killer Cell Immunoglobulin-Like Receptor 2DL42
CD158D2 3     Killer Ig Receptor2
G9P2 3     Natural Killer Cell Inhibitory Receptor2
KIR-103AS2 3     NK Cell Receptor2
CD158 Antigen-Like Family Member D2 3     CD158d Antigen3

External Ids:    HGNC: 63321   Entrez Gene: 38052   Ensembl: ENSG000001890137   OMIM: 6049455   UniProtKB: Q997063   

Export aliases for KIR2DL4 gene to outside databases

Previous GC identifers: GC19P055439 GC19P055661 GC19P059973 GC19P060007 GC00P9Q0057 GC19P9H0057 GC19P9I0057 GC19P060018 GC19P060022 GC19P060023 GC19P055239 GC19P055242 GC19P051637 GC19P055247 GC19P055250 GC19P055255 GC19P055260 GC19P055265 GC19P055272


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KIR2DL4 Gene:
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells
and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on
chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster
varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1,
KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or
3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic
domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM),
while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO
protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are
subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the
immune response. This gene is one of the 'framework' loci that is present on all haplotypes. Alternative splicing
results in multiple transcript variants. (provided by RefSeq, Jul 2008)

GeneCards Summary for KIR2DL4 Gene:
KIR2DL4 (killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4) is a protein-coding gene. Diseases associated with KIR2DL4 include recurrent respiratory papillomatosis, and leptospirosis. GO annotations related to this gene include transmembrane signaling receptor activity. An important paralog of this gene is LILRB4.

UniProtKB/Swiss-Prot: KI2L4_HUMAN, Q99706
Function: Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus
preventing cell lysis

Gene Wiki entry for KIR2DL4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  NT_113949.2  NT_187636.1  NT_187637.1  NT_187638.1  NT_187639.1  
NT_187640.1  NT_187641.1  NT_187642.1  NT_187643.1  NT_187644.1  NT_187645.1  NT_187668.1  NT_187669.1  
NT_187670.1  NT_187671.1  NT_187672.1  NT_187673.1  NT_187674.1  NT_187675.1  NT_187676.1  NT_187677.1  
NT_187683.1  NT_187684.1  NT_187685.1  NT_187686.1  NT_187687.1  NT_187693.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the KIR2DL4 gene promoter:
         GCNF   AREB6   CREB   RORalpha1   PPAR-gamma1   deltaCREB   GCNF-1   PPAR-gamma2   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKIR2DL4 promoter sequence
   Search Chromatin IP Primers for KIR2DL4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KIR2DL4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.4

KIR2DL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIR2DL4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P055276:  view genomic region     (about GC identifiers)

Start:
55,236,002 bp from pter      End:
55,325,972 bp from pter
Size:
89,971 bases      Orientation:
plus strand

2 alternative locations:
Chr19+,NW_003571060 707,934-718,882      Chr19+,NW_003571055 421,467-432,381     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KI2L4_HUMAN, Q99706 (See protein sequence)
Recommended Name: Killer cell immunoglobulin-like receptor 2DL4 precursor  
Size: 377 amino acids; 41487 Da
Subunit: Interacts with ARRB2
Secondary accessions: A8W795 O14621 O14622 O14623 O14624 O43534 P78400 P78401 Q8N738 Q99559
Q99560 Q99561 Q99562 Q9UQJ7
Alternative splicing: 6 isoforms:  Q99706-1   Q99706-2   Q99706-3   Q99706-4   Q99706-5   Q99706-6   

Explore the universe of human proteins at neXtProt for KIR2DL4: NX_Q99706

Explore proteomics data for KIR2DL4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn141, Asn175

  • See KIR2DL4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001074239.1  NP_001074241.1  NP_002246.5  

    ENSEMBL proteins: 
     ENSP00000351988   ENSP00000339634   ENSP00000350088   ENSP00000379588   ENSP00000345331  
     ENSP00000379584   ENSP00000379580  
    Reactome Protein details: Q99706

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    KIR: Killer cell immunoglobulin-like receptors
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    2 InterPro protein domains:
     IPR003599 Ig_sub
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q99706

    ProtoNet protein and cluster: Q99706

    UniProtKB/Swiss-Prot: KI2L4_HUMAN, Q99706
    Similarity: Belongs to the immunoglobulin superfamily
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


    Find genes that share domains with KIR2DL4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KI2L4_HUMAN, Q99706
    Function: Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus
    preventing cell lysis

         Genatlas biochemistry entry for KIR2DL4:
    natural killer cell immunoglobulin-like inhibitory receptor for HLA-C antigens,2DL4,with several alternatively
    spliced (truncated) forms

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS8946682
    GO:0005515protein binding IPI18604210
         
    Find genes that share ontologies with KIR2DL4           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KIR2DL4
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KI2L4_HUMAN, Q99706: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular3
    lysosome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8946682

    Find genes that share ontologies with KIR2DL4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KIR2DL4 About    
    See pathways by source

    SuperPathContained pathways About
    1Immune response Role of DAP12 receptors in NK cells
    Immune response Role of DAP12 receptors in NK cells0.33
    Natural killer cell mediated cytotoxicity0.31
    2Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    3Allograft rejection
    Antigen processing and presentation0.36
    4Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


    Find genes that share SuperPaths with KIR2DL4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for KIR2DL4
        Immune response Role of DAP12 receptors in NK cells


    1 Reactome Pathway for KIR2DL4
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


    2 Kegg Pathways  (Kegg details for KIR2DL4):
        Antigen processing and presentation
    Natural killer cell mediated cytotoxicity

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KIR2DL4
    Interactions:

        GeneGlobe Interaction Network for KIR2DL4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for KIR2DL4 (Q997063 ENSP000003396344) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000237216P176933, ENSP000004091324I2D: score=3 STRING: ENSP00000409132
    ENSG00000235346P176933, ENSP000003973314I2D: score=3 STRING: ENSP00000397331
    ENSG00000206506P176933I2D: score=3 
    ENSG00000230413P176933I2D: score=3 
    ENSG00000233095P176933I2D: score=3 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006968cellular defense response TAS8946682
    GO:0007165signal transduction TAS8946682
    GO:0050776regulation of immune response TAS--

    Find genes that share ontologies with KIR2DL4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KIR2DL4 (KI2L4)

    1 Novoseek inferred chemical compound relationship for KIR2DL4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arginine 11.5 1 11254692 (1)



    Find genes that share compounds with KIR2DL4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KIR2DL4 gene (3 alternative transcripts): 
    NM_001080770.1  NM_001080772.1  NM_002255.5  

    Unigene Cluster for KIR2DL4:

    Killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
    Hs.661219  [show with all ESTs]
    Unigene Representative Sequence: NM_002255
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000359085(uc021vbn.1 uc002qhh.3 uc002qhj.3 uc010esd.3 uc002qhf.3 uc002qhg.3 uc002qhi.3)
    ENST00000486965 ENST00000345540 ENST00000357494 ENST00000463062 ENST00000396293
    ENST00000346587 ENST00000396289(uc010yfl.2 uc010ese.3) ENST00000396284

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      QuantiFast Probe-based Assays in human, mouse, rat KIR2DL4

    Additional mRNA sequence: 

    AF002256.1 AF002980.1 AF002981.1 AF002982.1 AF034772.1 AF276292.1 AY052496.1 AY052497.1 
    AY223512.2 AY223513.1 AY223514.1 AY601812.1 AY789060.1 AY789061.1 BC028137.1 EU194341.1 
    X97229.1 X99480.1 X99481.1 

    3 DOTS entries:

    DT.452498  DT.86845912  DT.100777728 

    Selected AceView cDNA sequences (see all 93):

    AF285434 AF034773 AY052497 AY366242 AY223515 AY052498 AF208054 BC041611 
    BV204358 BV204359 BV199098 BV199186 AY223512 AF002979 AJ417558 X97229 
    BV206441 L76668 AF272389 BV183860 X99480 X98858 NM_012312 BV183858 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KIR2DL4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KIR2DL4 Expression
    About this image


    KIR2DL4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Natural Killer Cells Peripheral Blood
    KIR2DL4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KIR2DL4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.661219
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KIR2DL4 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    11(a)
    1 → many
    GL343329.1(1197670-1218701)
            Species with no ortholog for KIR2DL4

    ENSEMBL Gene Tree for KIR2DL4 (if available)
    TreeFam Gene Tree for KIR2DL4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KIR2DL4 gene
    LILRB42  LILRB12  KIR2DS42  LILRA62  LILRA52  IGSF12  KIR3DL12  OSCAR2  
    NCR12  LILRA42  ENSG000002177922  TARM12  KIR3DX12  LILRA32  LILRB52  KIR3DL32  
    LILRA12  KIR3DS12  KIR2DL12  A1BG2  LILRB22  KIR3DL22  LILRA22  KIR2DL32  
    FCAR2  GP62  LILRB32  
    Selected SIMAP similar genes for KIR2DL4 using alignment to 31 protein entries:     KI2L4_HUMAN (see all proteins) (see all similar genes):
    KIR-G2    KIR-G1    KIR2DL5A    KIR2DLX    KIR2DL5B    KIR411
    p140    KIR221    KIR2DL2    KIR-K15    KIR-K39    KIR2DL3
    KIR-K36    KIR2DS2    KIR2DP1DL1    KIR2DL1    KIR2DS2S3    KIR-K65

    Find genes that share paralogs with KIR2DL4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KIR2DL4 (see all 28)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1474930351,2
    C--55313098(+) AAATA-/TGATAA 3 -- us2k10--------
    rs1449784251,2
    C--55314801(+) ACATC-/ACAAAT 3 -- us2k10--------
    rs1485466281,2
    C--55317276(+) GAGTTA/GGGGGT 3 -- int10--------
    rs1821711951,2
    --55317291(+) GGTGAA/GAGAGA 3 -- int10--------
    rs1508139871,2
    C--55317958(+) AGACTC/GGGCTC 3 -- int10--------
    rs1503926921,2
    C--55318918(+) ATAGCG/TTTTCA 3 -- int10--------
    rs1928355711,2
    C--55321399(+) AATATC/TTTGGG 3 -- int10--------
    rs1453706911,2
    C--55321753(+) TTTTT-/TTTAGT 3 -- int10--------
    rs1135775711,2
    C,F--55322135(+) GAGACG/AGAGAG 3 -- int11Minor allele frequency- A:0.00WA 2
    rs1384272281,2
    C--55322702(+) ACAAAA/TACTAG 3 -- int10--------

    HapMap Linkage Disequilibrium report for KIR2DL4 (55236002 - 55325972 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for KIR2DL4 (see all 50):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2667609CNV Deletion23128226
    esv2661467CNV Deletion23128226
    esv2421952CNV Deletion20811451
    esv2718930CNV Deletion23290073
    esv2718872CNV Deletion23290073
    dgv668e199CNV Deletion23128226
    dgv575e201CNV Deletion23290073
    dgv577e201CNV Deletion23290073
    dgv667e199CNV Deletion23128226
    esv2718928CNV Deletion23290073

    Human Gene Mutation Database (HGMD): KIR2DL4
    Locus Specific Mutation Databases (LSDB): KIR2DL4

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604945    OMIM disorders: --

    3 diseases for KIR2DL4:    
    About MalaCards
    recurrent respiratory papillomatosis    leptospirosis    hematopoietic stem cell transplantation


    Find genes that share disorders with KIR2DL4           About GenesLikeMe

    1 Novoseek inferred disease relationship for KIR2DL4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 12616484 (1)

    Genetic Association Database (GAD): KIR2DL4
    Human Genome Epidemiology (HuGE) Navigator: KIR2DL4 (76 documents)

    Export disorders for KIR2DL4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for KIR2DL4 gene, integrated from 10 sources (see all 143):
    (articles sorted by number of sources associating them with KIR2DL4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NK cell receptor gene of the KIR family with two IG domains but highest homology to KIR receptors with three IG domains. (PubMed id 8946682)1, 2, 3, 9 Selvakumar A.... Dupont B. (Tissue Antigens 1996)
    2. [Correlation between killer cell immunoglobulin-like receptors genes and pre-eclampsia]. (PubMed id 19134329)1, 4, 9 Li Y....Cui M.H. (Zhonghua Fu Chan Ke Za Zhi 2008)
    3. The elucidation of KIR2DL4 gene polymorphism. (PubMed id 18082267)1, 2, 9 Schellekens J.... Rozemuller E.H. (Mol. Immunol. 2008)
    4. Genomic organization and allelic polymorphism of the human killer cell inhibitory receptor gene KIR103. (PubMed id 9234477)1, 2, 9 Selvakumar A.... Dupont B. (Tissue Antigens 1997)
    5. KIR haplotype content at the allele level in 77 Northern Irish families. (PubMed id 17200871)1, 4, 9 Middleton D....Gourraud P.A. (Immunogenetics 2007)
    6. Killer cell immunoglobulin-like receptor allele discrimination by high-resolution melting. (PubMed id 19589363)1, 4, 9 Gonzalez A....Middleton D. (Hum. Immunol. 2009)
    7. Diversity of killer cell immunoglobulin-like receptor genes in Indonesian populations of Java, Kalimantan, Timor and Irian Jaya. (PubMed id 19000141)1, 4, 9 Velickovic M....Dunckley H. (Tissue Antigens 2009)
    8. Killer immunoglobulin-like receptor ligand HLA-Bw4 protects against multiple sclerosis. (PubMed id 19630074)1, 4, 9 Lorentzen A.R....Harbo H.F. (Ann. Neurol. 2009)
    9. Polymorphisms of killer cell immunoglobulin-like receptor gene: possible association with susceptibility to or clearance of hepatitis B virus infection in Chinese Han population. (PubMed id 18074414)1, 4, 9 Zhi-ming L....Yue-ran Z. (Croat. Med. J. 2007)
    10. Association of killer cell immunoglobulin-like receptor 2DL5 with systemic lupus erythematosus and accompanying infections. (PubMed id 20371502)1, 4 Kimoto Y....Harada M. (Rheumatology (Oxford) 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 3805 HGNC: 6332 AceView: KIR2DL4 Ensembl:ENSG00000189013 euGenes: HUgn3805
    ECgene: KIR2DL4 Kegg: 3805 H-InvDB: KIR2DL4

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KIR2DL4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for KIR2DL4 gene:
    Search GeneIP for patents involving KIR2DL4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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