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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KIR2DL2 Gene

protein-coding   GIFtS: 52
GCID: GC19P9J0008

killer cell immunoglobulin-like receptor, two domains, long...

 Explore 44 diseases affiliated with
KIR2DL2 via our new
 Human Malady Compendium 
Biological research products
for KIR2DL2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic
Tail, 21 2
     P58 NK Receptor CL-432 3
CD158B11 2 3     CD158k1
NKAT62 3 5     Cl-431
Natural Killer-Associated Transcript 62 3     Nkat61
NKAT-62 3     CD158b2
CD158 Antigen-Like Family Member B12 3     Killer Cell Immunoglobulin-Like Receptor 2DL22
MHC Class I NK Cell Receptor2 3     P58.21
P58 Natural Killer Cell Receptor Clone CL-432 3     CD158b1 Antigen3

External Ids:    HGNC: 63301   Entrez Gene: 38032   Ensembl: ENSG000002157647   OMIM: 6049375   UniProtKB: P436273   

Export aliases for KIR2DL2 gene to outside databases

Previous GC identifers: GC19P055403 GC19P9D0021 GC19P9F0022 GC00P9Q0021 GC19P9H0021 GC19P059935 GC19P9I0021 GC19U901039


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KIR2DL2:
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and
subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome
19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among
haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The
KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have
a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals
upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short
cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to
transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR
proteins are thought to play an important role in regulation of the immune response. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KI2L2_HUMAN, P43627
Function: Receptor on natural killer (NK) cells for HLA-Cw1, 3, 7, and 8 allotypes. Inhibits the activity of NK cells
thus preventing cell lysis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:NT_113949.1  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for KIR2DL2
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIR2DL2


Genomic Location:
Chromosome:19   

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19_GL000209.1   HGNC cytogenetic band: 19q13.4 GRCh37 novel patch

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P9J0008:  view genomic region     (about GC identifiers)

Start:
7,891 bp from start of contig GL000209.1      End:
96,246 bp from start of contig GL000209.1
Size:
88,356 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KI2L2_HUMAN, P43627 (See protein sequence)
Recommended Name: Killer cell immunoglobulin-like receptor 2DL2 precursor  
Size: 348 amino acids; 38472 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein
3 PDB 3D structures from and Proteopedia for KIR2DL2:
1EFX (3D)        2DL2 (3D)        2DLI (3D)    
Secondary accessions: C6EVR8 Q14951

Explore the universe of human proteins at neXtProt for KIR2DL2: NX_P43627

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P43627

  • KIR2DL2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055034.2  
    ENSEMBL proteins: 
     ENSP00000375611   ENSP00000383672   ENSP00000383645   ENSP00000383649   ENSP00000343498  
     ENSP00000383652   ENSP00000383651   ENSP00000383650   ENSP00000383646   ENSP00000383644  
    Reactome Protein details: P43627
    Human Recombinant Protein Products: 
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    Uscn Proteins for KIR2DL2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane ----
    GO:0016021integral to membrane IEA--


    KIR2DL2 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    KIR2DL2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR013783 Ig-like_fold
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P43627

    ProtoNet protein and cluster: P43627

    1 Blocks protein family: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: KI2L2_HUMAN, P43627
    Similarity: Belongs to the immunoglobulin superfamily
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: KI2L2_HUMAN, P43627
    Function: Receptor on natural killer (NK) cells for HLA-Cw1, 3, 7, and 8 allotypes. Inhibits the activity of NK cells
    thus preventing cell lysis

         Genatlas biochemistry entry for KIR2DL2:
    natural killer cell immunoglobulin-like inhibitory receptor for HLA-C antigens,2DL2,58kDa,with alternatively spliced
    (truncated) forms

    miRNA
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity ----
    GO:0004888transmembrane signaling receptor activity ----
    GO:0005515protein binding ----
    GO:0032393MHC class I receptor activity ----


    KIR2DL2 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Immune System
    Immune System1.00
    Adaptive Immune System0.59
    2Allograft rejection
    Graft-versus-host disease0.63
    Antigen processing and presentation0.25
    3Immune response CD16 signaling in NK cells
    Immune response Role of DAP12 receptors in NK cells0.32
    Immune response_Role of DAP12 receptors in NK cells0.32
    4Natural killer cell mediated cytotoxicity
    Natural killer cell mediated cytotoxicity1.00
    5Cleavage of Alpha-1-Microglobulin
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell0.30

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for KIR2DL2
        Immune response Role of DAP12 receptors in NK cells


    1 GeneGo (Thomson Reuters) Pathway for KIR2DL2
        Immune response Role of DAP12 receptors in NK cells

    3        Reactome Pathways for KIR2DL2
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Adaptive Immune System
    Immune System


    3         Kegg Pathways  (Kegg details for KIR2DL2):
        Antigen processing and presentation
    Natural killer cell mediated cytotoxicity
    Graft-versus-host disease


    KIR2DL2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KIR2DL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/11 Interacting proteins for KIR2DL2 (P436273 ENSP000003836454) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD93Q9NPY33, ENSP000002460064I2D: score=1 STRING: ENSP00000246006
    HLA-CP103213, ENSP000003654024I2D: score=2 STRING: ENSP00000365402
    FCER1GENSP000002899024STRING: ENSP00000289902
    HLA-BENSP000003991684STRING: ENSP00000399168
    HLA-GENSP000003534724STRING: ENSP00000353472
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response ----
    GO:0006968cellular defense response ----
    GO:0007165signal transduction ----
    GO:0030101natural killer cell activation ----
    GO:0050776regulation of immune response TAS--


    KIR2DL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KIR2DL2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for KIR2DL2
    2 Novoseek chemical compound relationships for KIR2DL2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mannan 67.1 5 11021254 (2), 10224141 (1), 15711012 (1)
    mannose 47.5 3 15711012 (1), 7558162 (1)

    Search CenterWatch for drugs/clinical trials and news about KIR2DL2 / KI2L2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KIR2DL2 gene: 
    NM_014219.2  

    Unigene Cluster for KIR2DL2:

    Killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2
    Hs.743949
    Unigene Representative Sequence: NM_014219
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000391731 ENST00000400875(uc010euy.2) ENST00000400847 ENST00000400851(uc002qtv.3 uc010evf.3)
    ENST00000344867(uc002qtt.2 uc002qts.2) ENST00000400854(uc010evd.3 uc002quc.4)
    ENST00000400853(uc002qud.4) ENST00000400852(uc002quh.4 uc002que.4 uc002quf.4 uc010eve.3 uc002qug.4)
    ENST00000400848(uc010yic.2 uc021vdb.1 uc010yie.2 uc010evg.1 uc010evh.1 uc002qui.2)
    ENST00000400846(uc002quk.1)

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    Additional cDNA sequence: 

    AF285434.1 AY366242.1 L76669.1 U24075.1 

    2 DOTS entries:

    DT.95344548  DT.86840863 

    24/93 AceView cDNA sequences (see all 93):

    AY366242 AF285434 AY052497 AF034773 AY052498 AY223515 AF208054 AY366247 
    AF285436 BC041611 Y13054 AF022044 BV199098 X98858 BV199145 AF034772 
    BV206441 BV203729 BV204361 AF034771 X97229 AY601812 X99480 BV183860 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KIR2DL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See KIR2DL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KIR2DL2

    SOURCE GeneReport for Unigene cluster: Hs.743949
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    In Situ
    Assay Products:
     

     
    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for KIR2DL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for KIR2DL2 gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    --
    (see all 59)
    --
    25(a)
    24(a)
    (see all 59)
    many ↔ many
    many ↔ many
    (see all 59)
    Un(51843257-51844123)
    Un(7502858-7503788)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    --
    17(a)
    15(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    GL343329.1(1231914-1234163)
    GL343329.1(823590-844642)


    ENSEMBL Gene Tree for KIR2DL2 (if available)
    TreeFam Gene Tree for KIR2DL2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KIR2DL2 gene
    KIR2DL42  LILRB42  LILRB12  LILRA62  IGSF12  LILRA52  KIR3DL12  OSCAR2  
    NCR12  LILRA42  ENSG000002177922  TARM12  KIR3DX12  LILRA32  LILRB52  LILRA12  
    KIR3DL32  KIR2DL12  LILRB22  A1BG2  LILRA22  KIR3DL22  KIR2DL32  FCAR2  
    LILRB32  GP62  
    18/52 SIMAP similar genes for KIR2DL2 using alignment to 10 protein entries:     KI2L2_HUMAN (see all proteins) (see all similar genes):
    KIR412    KIR2DL3    KIR-G2    KIR-K36    KIR-K9    KIR2DL1
    KIR221    KIR-K3    KIR-K65    KIR-K78    KIR2DS2    KIR2DS
    KIR-K61    KIR-K64    KIR2DS1    p58    KIR2DS4    KIR-K15

    KIR2DL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Human Gene Mutation Database (HGMD): KIR2DL2

    Locus Specific Mutation Databases (LSDB): KIR2DL2
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    KIR2DL2 for disorders           About GeneDecksing

    OMIM gene information: 604937    OMIM disorders: --

    20/44 diseases for KIR2DL2 (see all 44):    About MalaCards
    vogt-koyanagi-harada disease    tropical spastic paraparesis    human immunodeficiency virus infectious disease    graft versus host disease
    spastic paraparesis    familial mediterranean fever    non-hodgkin lymphoma    cervical intraepithelial neoplasia
    type 1 diabetes mellitus    anterior uveitis    spontaneous abortion    ankylosing spondylitis
    systemic lupus erythematosus    lupus erythematosus    hodgkin's lymphoma    diabetes mellitus
    psoriatic arthritis    spasticity    uveitis    ulcerative colitis

    1 disease from the University of Copenhagen DISEASES database for KIR2DL2:
    Ankylosing spondylitis

    1 Novoseek disease relationship for KIR2DL2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    influenza 2.95 2 15711012 (1)

    Genetic Association Database (GAD): KIR2DL2
    Human Genome Epidemiology (HuGE) Navigator: KIR2DL2 (103 documents)

    Export disorders for KIR2DL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KIR2DL2 gene, integrated from 9 sources (see all 156):
    (articles sorted by number of sources associating them with KIR2DL2)
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    1. Alternatively spliced forms of human killer inhibitory receptors. (PubMed id 8662091)1, 2, 3 Dohring C....Colonna M. (1996)
    2. Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains. (PubMed id 7749980)1, 2, 3 Wagtmann N....Long E.O. (1995)
    3. Killer cell immunoglobulin-like receptor genes in Latvian patients with type 1 diabetes mellitus and healthy controls. (PubMed id 15699512)1, 4, 9 Nikitina-Zake L....Sanjeevi C.B. (2004)
    4. Comparison of killer Ig-like receptor genotyping and phenotyping for selection of allogeneic blood stem cell donors. (PubMed id 15879158)1, 4 Leung W....Handgretinger R. (2005)
    5. Activating killer cell immunoglobulin-like receptor gene KIR2DS1 is associated with psoriatic arthritis. (PubMed id 16112031)1, 4 Williams F....Middleton D. (2005)
    6. A population-based cohort study of KIR genes and genotypes in relation to cervical intraepithelial neoplasia. (PubMed id 15730517)1, 4 Arnheim L....Sanjeevi C.B. (2005)
    7. Genetic polymorphism of NK receptors and their ligands in melanoma patients: prevalence of inhibitory over activating signals. (PubMed id 15248031)1, 4 Naumova E....Toneva M. (2005)
    8. Distribution of killer cell immunoglobulin-like receptor genes in the Chinese Han population. (PubMed id 15896204)1, 4 Jiang K....Yan L.X. (2005)
    9. Genetic polymorphisms of killer cell immunoglobulin-like receptors are associated with susceptibility to psoriasis vulgaris. (PubMed id 15140215)1, 4 Suzuki Y....Muto M. (2004)
    10. Analysis of candidate genes on chromosome 19 in coeliac disease: an association study of the KIR and LILR gene clusters. (PubMed id 12121272)1, 4 Moodie S.J....Ciclitira P.J. (2002)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3803 HGNC: 6330 AceView: KIR2DL4 Ensembl:ENSG00000215764 euGenes: HUgn3803
    ECgene: KIR2DL2 Kegg: 3803 H-InvDB: KIR2DL2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KIR2DL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KIR2DL2 gene:
    Search GeneIP for patents involving KIR2DL2

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