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Aliases for KIR2DL2 Gene

Aliases for KIR2DL2 Gene

  • Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 2 2 3
  • NKAT6 3 4 6
  • P58 Natural Killer Cell Receptor Clone CL-43 3 4
  • Natural Killer-Associated Transcript 6 3 4
  • CD158 Antigen-Like Family Member B1 3 4
  • MHC Class I NK Cell Receptor 3 4
  • P58 NK Receptor CL-43 3 4
  • CD158B1 3 4
  • NKAT-6 3 4
  • Killer Cell Immunoglobulin-Like Receptor 2DL2 3
  • CD158b1 Antigen 4
  • CD158b 3
  • P58.2 3

External Ids for KIR2DL2 Gene

Summaries for KIR2DL2 Gene

Entrez Gene Summary for KIR2DL2 Gene

  • Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]

GeneCards Summary for KIR2DL2 Gene

KIR2DL2 (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 2) is a Protein Coding gene. Diseases associated with KIR2DL2 include recurrent respiratory papillomatosis and hematopoietic stem cell transplantation. Among its related pathways are Signaling by FGFR and Class I MHC mediated antigen processing and presentation.

UniProtKB/Swiss-Prot for KIR2DL2 Gene

  • Receptor on natural killer (NK) cells for HLA-Cw1, 3, 7, and 8 allotypes. Inhibits the activity of NK cells thus preventing cell lysis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIR2DL2 Gene

Genomics for KIR2DL2 Gene

Genomic Location for KIR2DL2 Gene

Start:
737,413 bp from pter
End:
751,952 bp from pter
Size:
14,540 bases
Orientation:
Plus strand

Genomic View for KIR2DL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:

No data available for Regulatory Elements for KIR2DL2 Gene

Proteins for KIR2DL2 Gene

  • Protein details for KIR2DL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43627-KI2L2_HUMAN
    Recommended name:
    Killer cell immunoglobulin-like receptor 2DL2
    Protein Accession:
    P43627
    Secondary Accessions:
    • C6EVR8
    • Q14951

    Protein attributes for KIR2DL2 Gene

    Size:
    348 amino acids
    Molecular mass:
    38472 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for KIR2DL2 Gene

neXtProt entry for KIR2DL2 Gene

Proteomics data for KIR2DL2 Gene at MOPED

Post-translational modifications for KIR2DL2 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn84, Asn178, and Asn211

Other Protein References for KIR2DL2 Gene

Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KIR2DL2 Gene

Domains for KIR2DL2 Gene

Gene Families for KIR2DL2 Gene

HGNC:
  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • KIR :Killer cell immunoglobulin-like receptors

Protein Domains for KIR2DL2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for KIR2DL2 Gene

Graphical View of Domain Structure for InterPro Entry

P43627

UniProtKB/Swiss-Prot:

KI2L2_HUMAN
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.:
    • P43627
Family:
  • Belongs to the immunoglobulin superfamily.:
    • P43627
genes like me logo Genes that share domains with KIR2DL2: view

Function for KIR2DL2 Gene

Molecular function for KIR2DL2 Gene

GENATLAS Biochemistry: natural killer cell immunoglobulin-like inhibitory receptor for HLA-C antigens,2DL2,58kDa,with alternatively spliced (truncated) forms
UniProtKB/Swiss-Prot Function: Receptor on natural killer (NK) cells for HLA-Cw1, 3, 7, and 8 allotypes. Inhibits the activity of NK cells thus preventing cell lysis.

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KIR2DL2 Gene

Localization for KIR2DL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIR2DL2 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIR2DL2 Gene COMPARTMENTS Subcellular localization image for KIR2DL2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KIR2DL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KIR2DL2: view

Pathways for KIR2DL2 Gene

genes like me logo Genes that share pathways with KIR2DL2: view

Interacting Proteins for KIR2DL2 Gene

Selected Interacting proteins: P43627-KI2L2_HUMAN for KIR2DL2 Gene via I2D

Symbol External ID(s) Details
CD93
HLA-C
--
  • Q96QL3 21

Gene Ontology (GO) - Biological Process for KIR2DL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with KIR2DL2: view

Compounds for KIR2DL2 Gene

(2) Novoseek inferred chemical compound relationships for KIR2DL2 Gene

Compound -log(P) Hits PubMed IDs
mannan 67.1 4
mannose 47.5 2
genes like me logo Genes that share compounds with KIR2DL2: view

Transcripts for KIR2DL2 Gene

Unigene Clusters for KIR2DL2 Gene

Killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIR2DL2 Gene

No ASD Table

Relevant External Links for KIR2DL2 Gene

GeneLoc Exon Structure for
KIR2DL2
ECgene alternative splicing isoforms for
KIR2DL2

Expression for KIR2DL2 Gene

mRNA expression in normal human tissues for KIR2DL2 Gene

SOURCE GeneReport for Unigene cluster for KIR2DL2 Gene Hs.743949

genes like me logo Genes that share expressions with KIR2DL2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for KIR2DL2 Gene

Orthologs for KIR2DL2 Gene

No data available for Orthologs and Evolution for KIR2DL2 Gene

Paralogs for KIR2DL2 Gene

genes like me logo Genes that share paralogs with KIR2DL2: view

No data available for Paralogs for KIR2DL2 Gene

Variants for KIR2DL2 Gene

Sequence variations from dbSNP and Humsavar for KIR2DL2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
VAR_021929 -
VAR_059417 -
VAR_059418 -

Relevant External Links for KIR2DL2 Gene

HapMap Linkage Disequilibrium report
KIR2DL2
Human Gene Mutation Database (HGMD)
KIR2DL2
Locus Specific Mutation Databases (LSDB)
KIR2DL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KIR2DL2 Gene

Disorders for KIR2DL2 Gene

(2) University of Copenhagen DISEASES for KIR2DL2 Gene

(1) Novoseek inferred disease relationships for KIR2DL2 Gene

Disease -log(P) Hits PubMed IDs
influenza 2.95 1

Relevant External Links for KIR2DL2

Genetic Association Database (GAD)
KIR2DL2
Human Genome Epidemiology (HuGE) Navigator
KIR2DL2
genes like me logo Genes that share disorders with KIR2DL2: view

No data available for UniProtKB/Swiss-Prot for KIR2DL2 Gene

Publications for KIR2DL2 Gene

  1. Killer cell immunoglobulin-like receptor genes in Latvian patients with type 1 diabetes mellitus and healthy controls. (PMID: 15699512) Nikitina-Zake L. … Sanjeevi C.B. (Ann. N. Y. Acad. Sci. 2004) 3 23 48
  2. HLA-C and KIR genes in hepatitis C virus infection. (PMID: 16571411) Montes-Cano M.A. … GonzA!lez-Escribano M.F. (Hum. Immunol. 2005) 3 23 48
  3. Killer cell immunoglobulin-like receptor (KIR) genes in the Basque population: association study of KIR gene contents with type 1 diabetes mellitus. (PMID: 16698433) Santin I. … Bilbao J.R. (Hum. Immunol. 2006) 3 23 48
  4. KIR haplotype content at the allele level in 77 Northern Irish families. (PMID: 17200871) Middleton D. … Gourraud P.A. (Immunogenetics 2007) 3 23 48
  5. Association of KIR2DL2 polymorphism rs2756923 with type 1 diabetes and preliminary evidence for lack of inhibition through HLA-C1 ligand binding. (PMID: 19392800) Ramos-Lopez E. … Badenhoop K. (Tissue Antigens 2009) 3 23 48

Products for KIR2DL2 Gene

Sources for KIR2DL2 Gene

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