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KIR2DL2 Gene

protein-coding   GIFtS: 51
GCID: GC19P9I0029

Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long...

  See KIR2DL2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic
Tail, 21 2
     P58 Natural Killer Cell Receptor Clone CL-432 3
NKAT62 3 5     P58 NK Receptor CL-432 3
Natural Killer-Associated Transcript 62 3     CD158b2
CD158B12 3     Killer Cell Immunoglobulin-Like Receptor 2DL22
NKAT-62 3     p58.22
CD158 Antigen-Like Family Member B12 3     CD158b1 Antigen3
MHC Class I NK Cell Receptor2 3     

External Ids:    HGNC: 63301   Entrez Gene: 38032   Ensembl: ENSG000002157647   OMIM: 6049375   UniProtKB: P436273   

Export aliases for KIR2DL2 gene to outside databases

Previous GC identifers: GC19P055403 GC19P9D0021 GC19P9F0022 GC00P9Q0021 GC19P9H0021 GC19P059935 GC19P9I0021 GC19U901039 GC19P9J0008 GC19P9I0006


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KIR2DL2 Gene:
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells
and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on
chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster
varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1,
KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or
3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic
domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM),
while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO
protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are
subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the
immune response. (provided by RefSeq, Jul 2008)

GeneCards Summary for KIR2DL2 Gene:
KIR2DL2 (killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2) is a protein-coding gene. Diseases associated with KIR2DL2 include recurrent respiratory papillomatosis, and leptospirosis. An important paralog of this gene is LILRB4.

UniProtKB/Swiss-Prot: KI2L2_HUMAN, P43627
Function: Receptor on natural killer (NK) cells for HLA-Cw1, 3, 7, and 8 allotypes. Inhibits the activity of NK
cells thus preventing cell lysis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for KIR2DL2
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for KIR2DL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KIR2DL2


Genomic Location:
Chromosome:19   

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19_GL000209.1   HGNC cytogenetic band: 19q13.4 alternate reference locus

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P9I0029:       (about GC identifiers)

Start:
21,917 bp from start of contig NT_113949      End:
36,449 bp from start of contig NT_113949
Size:
14,533 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KI2L2_HUMAN, P43627 (See protein sequence)
Recommended Name: Killer cell immunoglobulin-like receptor 2DL2 precursor  
Size: 348 amino acids; 38472 Da
3 PDB 3D structures from and Proteopedia for KIR2DL2:
1EFX (3D)        2DL2 (3D)        2DLI (3D)    
Secondary accessions: C6EVR8 Q14951

Explore the universe of human proteins at neXtProt for KIR2DL2: NX_P43627

Explore proteomics data for KIR2DL2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn84, Asn178, Asn211
  • Modification sites at PhosphoSitePlus

  • See KIR2DL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055034.2  
    ENSEMBL proteins: 
     ENSP00000375611   ENSP00000383645   ENSP00000383649   ENSP00000383672   ENSP00000343498  
     ENSP00000383652   ENSP00000383651   ENSP00000383650   ENSP00000383646   ENSP00000383644  
    Reactome Protein details: P43627

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    KIR: Killer cell immunoglobulin-like receptors
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    2 InterPro protein domains:
     IPR003599 Ig_sub
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry P43627

    ProtoNet protein and cluster: P43627

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: KI2L2_HUMAN, P43627
    Similarity: Belongs to the immunoglobulin superfamily
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


    Find genes that share domains with KIR2DL2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KI2L2_HUMAN, P43627
    Function: Receptor on natural killer (NK) cells for HLA-Cw1, 3, 7, and 8 allotypes. Inhibits the activity of NK
    cells thus preventing cell lysis

         Genatlas biochemistry entry for KIR2DL2:
    natural killer cell immunoglobulin-like inhibitory receptor for HLA-C antigens,2DL2,58kDa,with alternatively
    spliced (truncated) forms

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032393MHC class I receptor activity ----
         
    Find genes that share ontologies with KIR2DL2           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for KIR2DL2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KI2L2_HUMAN, P43627: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    lysosome1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with KIR2DL2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KIR2DL2 About    
    See pathways by source

    SuperPathContained pathways About
    1Immune response Role of DAP12 receptors in NK cells
    Immune response Role of DAP12 receptors in NK cells0.33
    Natural killer cell mediated cytotoxicity0.31
    2Allograft rejection
    Graft-versus-host disease0.65
    Antigen processing and presentation0.36
    3Signaling by FGFR
    DAP12 interactions0.89
    4Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    5Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


    Find genes that share SuperPaths with KIR2DL2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for KIR2DL2
        Immune response Role of DAP12 receptors in NK cells

    1 Reactome Pathway for KIR2DL2
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


    3 Kegg Pathways  (Kegg details for KIR2DL2):
        Antigen processing and presentation
    Natural killer cell mediated cytotoxicity
    Graft-versus-host disease

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KIR2DL2
    Interactions:

        GeneGlobe Interaction Network for KIR2DL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for KIR2DL2 (P436273 ENSP000003836454) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD93Q9NPY33, ENSP000002460064I2D: score=1 STRING: ENSP00000246006
    HLA-CP103213, ENSP000003654024I2D: score=2 STRING: ENSP00000365402
    FCER1GENSP000002899024STRING: ENSP00000289902
    HLA-BENSP000003991684STRING: ENSP00000399168
    HLA-GENSP000003534724STRING: ENSP00000353472
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response ----
    GO:0030101natural killer cell activation ----
    GO:0045087innate immune response ----
    GO:0050776regulation of immune response TAS--

    Find genes that share ontologies with KIR2DL2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KIR2DL2 (KI2L2)

    2 Novoseek inferred chemical compound relationships for KIR2DL2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mannan 67.1 5 11021254 (2), 10224141 (1), 15711012 (1)
    mannose 47.5 3 15711012 (1), 7558162 (1)



    Find genes that share compounds with KIR2DL2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KIR2DL2 gene: 
    NM_014219.2  

    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000391731 ENST00000400847 ENST00000400851(uc002qtv.3 uc010evf.3)
    ENST00000400875(uc010euy.2) ENST00000344867(uc002qtt.2 uc002qts.2)
    ENST00000400854(uc010evd.3 uc002quc.4) ENST00000400853(uc002qud.4)
    ENST00000400852(uc002quh.4 uc002que.4 uc002quf.4 uc010eve.3 uc002qug.4)
    ENST00000400848(uc010yic.2 uc021vdb.1 uc010yie.2 uc010evg.1 uc010evh.1 uc002qui.2)
    ENST00000400846(uc002quk.1)
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    Selected AceView cDNA sequences (see all 93):

    AY366242 AF034773 AY052498 AY052497 AF285434 AY223515 AF208054 BV180934 
    AY366247 AF034772 L76661 AY359817 NM_002255 AF002981 U73394 AF034771 
    BV204359 L41347 AF272389 L76668 BV206441 U24075 BV199186 X98858 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KIR2DL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KIR2DL2 Expression
    About this image

    KIR2DL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KIR2DL2 Protein Expression
        Custom PCR Arrays for KIR2DL2
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KIR2DL2 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    16(a)
    1 → many
    GL343329.1(1197670-1218701)
            Species with no ortholog for KIR2DL2

    ENSEMBL Gene Tree for KIR2DL2 (if available)
    TreeFam Gene Tree for KIR2DL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KIR2DL2 gene
    LILRB42  KIR2DL42  LILRB12  KIR2DS42  LILRA62  LILRA52  IGSF12  KIR3DL12  
    OSCAR2  NCR12  LILRA42  ENSG000002177922  TARM12  KIR3DX12  LILRA32  LILRB52  
    KIR3DL32  LILRA12  KIR2DL12  A1BG2  LILRB22  KIR3DL22  LILRA22  KIR2DL32  
    FCAR2  GP62  LILRB32  
    Selected SIMAP similar genes for KIR2DL2 using alignment to 10 protein entries:     KI2L2_HUMAN (see all proteins) (see all similar genes):
    KIR412    KIR2DL3    KIR-G2    KIR-K9    KIR2DP1DL1    KIR-K36
    KIR2DL1    KIR-K78    KIR221    KIR-K3    KIR-K65    KIR2DS2S3
    KIR2DS2    KIR2DS    KIR-K61    p58    KIR-K64    KIR2DS1

    Find genes that share paralogs with KIR2DL2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    3 SNPs for KIR2DL2    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs6132401,2,4
    ----see VAR_0219292 mis40--------
    rs38103431,2,4
    ----see VAR_0594172 mis40--------
    rs6735681,2,4
    ----see VAR_0594182 mis40--------

    HapMap Linkage Disequilibrium report for KIR2DL2 (21917 - 36449 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for KIR2DL2: --
    Human Gene Mutation Database (HGMD): KIR2DL2
    Locus Specific Mutation Databases (LSDB): KIR2DL2

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing KIR2DL2
    DNA2.0 Custom Variant and Variant Library Synthesis for KIR2DL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604937    OMIM disorders: --

    7 diseases for KIR2DL2:    
    About MalaCards
    recurrent respiratory papillomatosis    leptospirosis    hematopoietic stem cell transplantation    spondyloarthropathy
    anterior uveitis    acquired immunodeficiency syndrome    type 1 diabetes mellitus

    2 diseases from the University of Copenhagen DISEASES database for KIR2DL2:
    Acquired immunodeficiency syndrome     Ankylosing spondylitis

    Find genes that share disorders with KIR2DL2           About GenesLikeMe

    1 Novoseek inferred disease relationship for KIR2DL2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    influenza 2.95 2 15711012 (1)

    Genetic Association Database (GAD): KIR2DL2
    Human Genome Epidemiology (HuGE) Navigator: KIR2DL2 (103 documents)

    Export disorders for KIR2DL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KIR2DL2 gene, integrated from 10 sources (see all 160):
    (articles sorted by number of sources associating them with KIR2DL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Alternatively spliced forms of human killer inhibitory receptors. (PubMed id 8662091)1, 2, 3 Doehring C.... Colonna M. (Immunogenetics 1996)
    2. Molecular clones of the p58 NK cell receptor reveal immunoglobulin- related molecules with diversity in both the extra- and intracellular domains. (PubMed id 7749980)1, 2, 3 Wagtmann N.... Long E.O. (Immunity 1995)
    3. Susceptibility to Crohn's disease is mediated by KIR2DL2/KIR2DL3 heterozygosity and the HLA-C ligand. (PubMed id 19789864)1, 4, 9 Hollenbach J.A....Trachtenberg E.A. (Immunogenetics 2009)
    4. Killer cell immunoglobulin-like receptor genes in Latvian patients with type 1 diabetes mellitus and healthy controls. (PubMed id 15699512)1, 4, 9 Nikitina-Zake L....Sanjeevi C.B. (Ann. N. Y. Acad. Sci. 2004)
    5. Killer immunoglobulin-like receptors (KIR2DL2 and/or KIR2DS2) in presence of their ligand (HLA-C1 group) protect against chronic myeloid leukaemia. (PubMed id 19493232)1, 4, 9 Middleton D....Gourraud P.A. (Tissue Antigens 2009)
    6. Lack of killer immunoglobulin-like receptor 2DS2 (KIR2DS2) and KIR2DL2 is associated with poor responses to therapy of recurrent hepatitis C virus in liver transplant recipients. (PubMed id 19877200)1, 4, 9 Askar M....Zein N.N. (Liver Transpl. 2009)
    7. Association of KIR2DL2 polymorphism rs2756923 with type 1 diabetes and preliminary evidence for lack of inhibition through HLA-C1 ligand binding. (PubMed id 19392800)1, 4, 9 Ramos-Lopez E....Badenhoop K. (Tissue Antigens 2009)
    8. HLA-C and KIR genes in hepatitis C virus infection. (PubMed id 16571411)1, 4, 9 Montes-Cano M.A....GonzA!lez-Escribano M.F. (Hum. Immunol. 2005)
    9. KIR haplotype content at the allele level in 77 Northern Irish families. (PubMed id 17200871)1, 4, 9 Middleton D....Gourraud P.A. (Immunogenetics 2007)
    10. Killer cell immunoglobulin-like receptor (KIR) genes in the Basque population: association study of KIR gene contents with type 1 diabetes mellitus. (PubMed id 16698433)1, 4, 9 Santin I....Bilbao J.R. (Hum. Immunol. 2006)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3803 HGNC: 6330 AceView: KIR2DL4 Ensembl:ENSG00000215764 euGenes: HUgn3803
    ECgene: KIR2DL2 Kegg: 3803 H-InvDB: KIR2DL2

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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    PharmGKB entry for KIR2DL2 Pharmacogenomics, SNPs, Pathways

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