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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KIR2DL1 Gene

protein-coding   GIFtS: 65
GCID: GC19P055283

Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic
Tail, 11 2
     KIR-K642
NKAT12 3 5     KIR2212
Natural Killer-Associated Transcript 12 3     NKAT2
CD158A2 3     Killer Cell Immunoglobulin-Like Receptor 2DL12
NKAT-12 3     Killer Ig Receptor2
CD158 Antigen-Like Family Member A2 3     Killer Inhibitory Receptor 2-2-12
MHC Class I NK Cell Receptor2 3     P58 Killer Cell Inhibitory Receptor KIR-K642
P58 Natural Killer Cell Receptor Clones CL-42/47.112 3     P58 NK Cell Inhibitory Receptor NKR-K62
P58 NK Receptor CL-42/47.112 3     p58.12
P58.1 MHC Class-I-Specific NK Receptor2 3     CD158a Antigen3

External Ids:    HGNC: 63291   Entrez Gene: 38022   Ensembl: ENSG000001254987   OMIM: 6049365   UniProtKB: P436263   

Export aliases for KIR2DL1 gene to outside databases

Previous GC identifers: GC19P056112 GC19P055660 GC19P059720 GC19P059736 GC19P059974 GC19P059975 GC19P059938 GC19P059980 GC19P059983 GC19P055282


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KIR2DL1 Gene:
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells
and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on
chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster
varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1,
KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or
3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic
domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM),
while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO
protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are
subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the
immune response. (provided by RefSeq, Jul 2008)

GeneCards Summary for KIR2DL1 Gene: 
KIR2DL1 (killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1) is a protein-coding gene. Diseases associated with KIR2DL1 include t-cell large granular lymphocyte leukemia, and large granular lymphocyte leukemia, and among its related super-pathways are Immune response Role of DAP12 receptors in NK cells and Allograft rejection. GO annotations related to this gene include protein binding and receptor activity. An important paralog of this gene is LILRB4.

UniProtKB/Swiss-Prot: KI2L1_HUMAN, P43626
Function: Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus
preventing cell lysis

Gene Wiki entry for KIR2DL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KIR2DL1 gene promoter:
         RORalpha1   GATA-3   Pax-2   Pax-2a   GATA-1   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKIR2DL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for KIR2DL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIR2DL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.4

KIR2DL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIR2DL1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P055283:  view genomic region     (about GC identifiers)

Start:
55,281,263 bp from pter      End:
55,295,778 bp from pter
Size:
14,516 bases      Orientation:
plus strand

4 alternative locations:
Chr19+,NW_003571057 841,925-856,418      Chr19+,NW_003571054 675,474-689,985      Chr19+,NW_003571059 752,648-767,141     
Chr19+,NW_003571060 674,147-688,660     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KI2L1_HUMAN, P43626 (See protein sequence)
Recommended Name: Killer cell immunoglobulin-like receptor 2DL1 precursor  
Size: 348 amino acids; 38505 Da
Subunit: Interacts with ARRB2. Interacts with PTPN6; the interaction is enhanced by ARRB2. Interacts with PTPN11;
the interaction is enhanced by ARRB2
Subcellular location: Cell membrane; Single-pass type I membrane protein
2 PDB 3D structures from and Proteopedia for KIR2DL1:
1IM9 (3D)        1NKR (3D)    
Secondary accessions: O43470 Q32WE6

Explore the universe of human proteins at neXtProt for KIR2DL1: NX_P43626

Explore proteomics data for KIR2DL1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P43626

  • KIR2DL1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KIR2DL1 Protein Expression
    REFSEQ proteins: NP_055033.2  
    ENSEMBL proteins: 
     ENSP00000336769   ENSP00000291633  
    Reactome Protein details: P43626
    Human Recombinant Protein Products for KIR2DL1: 
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    Sino Biological Cell Lysate for KIR2DL1 
    ProSpec Recombinant Protein for KIR2DL1
    Cloud-Clone Corp. Proteins for KIR2DL1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS7749980

    KIR2DL1 for ontologies           About GeneDecksing



    KIR2DL1 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    KIR: Killer cell immunoglobulin-like receptors
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    3 InterPro protein domains:
     IPR003599 Ig_sub
     IPR013783 Ig-like_fold
     IPR013151 Immunoglobulin

    Graphical View of Domain Structure for InterPro Entry P43626

    ProtoNet protein and cluster: P43626

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: KI2L1_HUMAN, P43626
    Similarity: Belongs to the immunoglobulin superfamily
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


    KIR2DL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KI2L1_HUMAN, P43626
    Function: Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus
    preventing cell lysis

         Genatlas biochemistry entry for KIR2DL1:
    natural killer cell immunoglobulin-like inhibitory receptor for HLA-C antigen,2DL1,58kDa

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS7749980
    GO:0005515protein binding IPI18604210
         
    KIR2DL1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KIR2DL1:
     Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for KIR2DL1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KIR2DL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KIR2DL1 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KIR2DL1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Immune response Fc epsilon RI pathway
    Immune response Role of DAP12 receptors in NK cells0.32
    Natural killer cell mediated cytotoxicity0.31
    2Allograft rejection
    Graft-versus-host disease0.65
    Antigen processing and presentation0.37
    3Immune System
    Immune System0.56
    Adaptive Immune System0.56
    4Classical antibody-mediated complement activation
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell0.30

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for KIR2DL1
        Immune response Role of DAP12 receptors in NK cells


    1 GeneGo (Thomson Reuters) Pathway for KIR2DL1
        Immune response Role of DAP12 receptors in NK cells


    3        Reactome Pathways for KIR2DL1
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Adaptive Immune System
    Immune System


    3         Kegg Pathways  (Kegg details for KIR2DL1):
        Antigen processing and presentation
    Natural killer cell mediated cytotoxicity
    Graft-versus-host disease


    KIR2DL1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KIR2DL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/12 Interacting proteins for KIR2DL1 (P436262, 3 ENSP000003367694) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN6P293502, 3, ENSP000003915924MINT-8035707 MINT-8035722 MINT-8027477 MINT-8027492 I2D: score=2 STRING: ENSP00000391592
    PTPN11Q061242, 3, ENSP000003409444MINT-8027537 MINT-8027552 I2D: score=2 STRING: ENSP00000340944
    PIK3R1P279862, 3, ENSP000002743354MINT-8027522 MINT-8027507 I2D: score=1 STRING: ENSP00000274335
    HLA-CP103213, ENSP000003654024I2D: score=3 STRING: ENSP00000365402
    ARRB2P321213I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002769natural killer cell inhibitory signaling pathway IDA18604210
    GO:0006955immune response TAS7749980
    GO:0050776regulation of immune response TAS--

    KIR2DL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KIR2DL1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KIR2DL1 (KI2L1)

    2 Novoseek inferred chemical compound relationships for KIR2DL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lipid 0 3 11724921 (1), 12351398 (1)
    tyrosine 0 2 11034353 (1), 12351398 (1)

    Search CenterWatch for drugs/clinical trials and news about KIR2DL1 / KI2L1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KIR2DL1 gene: 
    NM_014218.2  

    Unigene Clusters for KIR2DL1:

    Killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
    Hs.654605  [show with all ESTs], Hs.690615
    Unigene Representative Sequences: X93595, AJ630586
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336077(uc010erz.1 uc002qhb.1) ENST00000291633
    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIR2DL1

    Additional mRNA sequence: 

    AJ630586.1 U96189.1 XR_159106.1 

    4 DOTS entries:

    DT.92058638  DT.86840863  DT.121450410  DT.95344548 

    5 AceView cDNA sequences:

    NM_153443 L41268 BI909683 NM_014218 NM_014511 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KIR2DL1 expression in normal human tissues (normalized intensities)      KIR2DL1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KIR2DL1 Expression
    About this image


    KIR2DL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Blood (Hematopoietic System)
             Natural killer-like cells ( Derivation of hematopoietic progenitor cells and natural...

    See KIR2DL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KIR2DL1

    SOURCE GeneReport for Unigene clusters: Hs.654605 Hs.690615
        SABiosciences Custom PCR Arrays for KIR2DL1
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for KIR2DL1 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves IGSF16
    --
    (see all 62)
    --
    9(a)
    27(a)
    (see all 62)
    many ↔ many
    many ↔ many
    (see all 62)
    20(40715-45256)
    JH376121.1(3529-4219)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    9(a)
    8(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    GL343329.1(1229430-1238742)
    GL343329.1(1197670-1218701)
            Species with no ortholog for KIR2DL1

    ENSEMBL Gene Tree for KIR2DL1 (if available)
    TreeFam Gene Tree for KIR2DL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KIR2DL1 gene
    KIR2DL31 2  LILRB42  KIR2DL42  LILRB12  KIR2DS42  LILRA62  LILRA52  IGSF12  
    KIR3DL12  OSCAR2  NCR12  LILRA42  ENSG000002177922  TARM12  KIR3DX12  LILRA32  
    LILRB52  KIR3DL32  LILRA12  KIR3DS12  LILRB22  A1BG2  KIR3DL22  LILRA22  
    FCAR2  GP62  LILRB32  
    18/55 SIMAP similar genes for KIR2DL1 using alignment to 20 protein entries:     KI2L1_HUMAN (see all proteins) (see all similar genes):
    KIR-K3    KIR-K64    KIR2DP1DL1    KIR-K9    KIR-G2    KIR2DS1
    KIR2DL2    KIR412    KIR2DL3    KIR-K65    KIR-K61    KIR-K15
    KIR-K78    KIR221    KIR-K36    p58    KIR2DS2S3    KIR2DS

    KIR2DL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/355 SNPs in KIR2DL1 are shown (see all 355)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0103334
    ----see VAR_0103332 H R mis40--------
    VAR_0103314
    ----see VAR_0103312 P T mis40--------
    VAR_0039514
    ----see VAR_0039512 P L mis40--------
    VAR_0613334
    ----see VAR_0613332 V L mis40--------
    VAR_0103354
    ----see VAR_0103352 R C mis40--------
    VAR_0039504
    ----see VAR_0039502 P R mis40--------
    VAR_0103324
    ----see VAR_0103322 D N mis40--------
    VAR_0103344
    ----see VAR_0103342 K E mis40--------
    VAR_0613324
    ----see VAR_0613322 A V mis40--------
    VAR_0039494
    ----see VAR_0039492 V F mis40--------

    HapMap Linkage Disequilibrium report for KIR2DL1 (55281263 - 55295778 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/42 variations for KIR2DL1 (see all 42):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2667609CNV Deletion23128226
    esv2661467CNV Deletion23128226
    esv2421952CNV Deletion20811451
    esv2718927CNV Deletion23290073
    esv2718872CNV Deletion23290073
    dgv668e199CNV Deletion23128226
    nsv436250CNV Deletion17901297
    esv2718925CNV Deletion23290073
    dgv575e201CNV Deletion23290073
    dgv577e201CNV Deletion23290073


    Human Gene Mutation Database (HGMD): KIR2DL1

    Locus Specific Mutation Databases (LSDB): KIR2DL1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KIR2DL1
    DNA2.0 Custom Variant and Variant Library Synthesis for KIR2DL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604936    OMIM disorders: --

    20/54 diseases for KIR2DL1 (see all 54):    About MalaCards
    t-cell large granular lymphocyte leukemia    large granular lymphocyte leukemia    hematopoietic stem cell transplantation    behcet's disease
    birdshot chorioretinopathy    microscopic polyangiitis    anterior uveitis    vogt-koyanagi-harada disease
    leptospirosis    spondyloarthropathy    tropical spastic paraparesis    cutaneous t cell lymphoma
    psoriatic arthritis    spastic paraparesis    familial mediterranean fever    uveitis
    cervical intraepithelial neoplasia    hiv type 1    ankylosing spondylitis    leprosy


    KIR2DL1 for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for KIR2DL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma t-cell 40.6 3 11253136 (2)
    behcet disease 27.6 1 11229470 (1)
    autoimmune diseases 0 3 11229470 (2)
    rheumatoid arthritis 0 1 11229470 (1)
    tumors 0 4 11724921 (1), 15312339 (1), 12351398 (1)
    melanoma 0 1 16914567 (1)

    Genetic Association Database (GAD): KIR2DL1
    Human Genome Epidemiology (HuGE) Navigator: KIR2DL1 (103 documents)

    Export disorders for KIR2DL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KIR2DL1 gene, integrated from 9 sources (see all 197):
    (articles sorted by number of sources associating them with KIR2DL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains. (PubMed id 7749980)1, 2, 3 Wagtmann N....Long E.O. (1995)
    2. Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. (PubMed id 7716543)1, 2, 3 Colonna M. and Samaridis J. (1995)
    3. [Distribution of immunoglobulinlike receptor gene in Han population in China and the impact thereof on the HLA-identical sibling hematopoietic stem cell transplantation] (PubMed id 18269867)1, 4, 9 Dou L.P....Yu L. (2007)
    4. [Differential expression levels of killer immunoglobin-like receptor genotype in patients with hematological malignancies between high-risk and standard-risk groups] (PubMed id 18718052)1, 4, 9 Zhao X.Y....Huang X.J. (2008)
    5. Killer cell immunoglobulin-like receptor genotypes in Japanese patients with type 1 diabetes. (PubMed id 17990989)1, 4, 9 Mogami S....Nakamura N. (2007)
    6. Comparison of killer Ig-like receptor genotyping and phenotyping for selection of allogeneic blood stem cell donors. (PubMed id 15879158)1, 4, 9 Leung W....Handgretinger R. (2005)
    7. HLA-C and KIR genes in hepatitis C virus infection. (PubMed id 16571411)1, 4, 9 Montes-Cano M.A....Gonzalez-Escribano M.F. (2005)
    8. Association of killer cell immunoglobulin-like recept or 2DL5 with systemic lupus erythematosus and accompanying infections. (PubMed id 20371502)1, 4 Kimoto Y....Harada M. (2010)
    9. Immunogenetic characteristics of patients with autoim mune gastritis. (PubMed id 20082482)1, 4 Oksanen A.M....Partanen J.A. (2010)
    10. Association of KIR2DS1 and KIR2DS3 with fatal outcome in Ebola virus infection. (PubMed id 20878400)1, 4 Wauquier N....Vieillard V. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3802 HGNC: 6329 AceView: KIR2DL1 Ensembl:ENSG00000125498 euGenes: HUgn3802
    ECgene: KIR2DL1 Kegg: 3802 H-InvDB: KIR2DL1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KIR2DL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KIR2DL1 gene:
    Search GeneIP for patents involving KIR2DL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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