Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



KIR2DL1 Gene

protein-coding   GIFtS: 65
GCID: GC19P055283

Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic
Tail, 11 2
     KIR-K642
NKAT12 3 5     KIR2212
Natural Killer-Associated Transcript 12 3     NKAT2
CD158A2 3     Killer Cell Immunoglobulin-Like Receptor 2DL12
NKAT-12 3     Killer Ig Receptor2
CD158 Antigen-Like Family Member A2 3     Killer Inhibitory Receptor 2-2-12
MHC Class I NK Cell Receptor2 3     P58 Killer Cell Inhibitory Receptor KIR-K642
P58 Natural Killer Cell Receptor Clones CL-42/47.112 3     P58 NK Cell Inhibitory Receptor NKR-K62
P58 NK Receptor CL-42/47.112 3     p58.12
P58.1 MHC Class-I-Specific NK Receptor2 3     CD158a Antigen3

External Ids:    HGNC: 63291   Entrez Gene: 38022   Ensembl: ENSG000001254987   OMIM: 6049365   UniProtKB: P436263   

Export aliases for KIR2DL1 gene to outside databases

Previous GC identifers: GC19P056112 GC19P055660 GC19P059720 GC19P059736 GC19P059974 GC19P059975 GC19P059938 GC19P059980 GC19P059983 GC19P055282


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for KIR2DL1 Gene:
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells
and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on
chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster
varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1,
KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or
3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic
domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM),
while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO
protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are
subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the
immune response. (provided by RefSeq, Jul 2008)

GeneCards Summary for KIR2DL1 Gene:
KIR2DL1 (killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1) is a protein-coding gene. Diseases associated with KIR2DL1 include t-cell large granular lymphocyte leukemia, and large granular lymphocyte leukemia. GO annotations related to this gene include receptor activity. An important paralog of this gene is LILRB4.

UniProtKB/Swiss-Prot: KI2L1_HUMAN, P43626
Function: Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus
preventing cell lysis

Gene Wiki entry for KIR2DL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NT_187693.1  NC_000019.10  NT_011109.17  NT_187636.1  NT_187637.1  NT_187639.1  NT_187641.1  NT_187643.1  
NT_187644.1  NT_187645.1  NT_187669.1  NT_187670.1  NT_187671.1  NT_187672.1  NT_187673.1  NT_187675.1  
NT_187676.1  NT_187685.1  NT_113949.2  NC_018930.2  NT_187640.1  NT_187668.1  NT_187674.1  NT_187683.1  
NT_187684.1  NT_187686.1  NT_187687.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the KIR2DL1 gene promoter:
         RORalpha1   GATA-3   Pax-2   Pax-2a   GATA-1   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKIR2DL1 promoter sequence
   Search Chromatin IP Primers for KIR2DL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KIR2DL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.4

KIR2DL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIR2DL1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P055283:  view genomic region     (about GC identifiers)

Start:
55,281,263 bp from pter      End:
55,295,778 bp from pter
Size:
14,516 bases      Orientation:
plus strand

4 alternative locations:
Chr19+,NW_003571059 752,648-767,141      Chr19+,NW_003571060 674,147-688,660      Chr19+,NW_003571054 675,474-689,985     
Chr19+,NW_003571057 841,925-856,418     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: KI2L1_HUMAN, P43626 (See protein sequence)
Recommended Name: Killer cell immunoglobulin-like receptor 2DL1 precursor  
Size: 348 amino acids; 38505 Da
Subunit: Interacts with ARRB2. Interacts with PTPN6; the interaction is enhanced by ARRB2. Interacts with PTPN11;
the interaction is enhanced by ARRB2
2 PDB 3D structures from and Proteopedia for KIR2DL1:
1IM9 (3D)        1NKR (3D)    
Secondary accessions: O43470 Q32WE6

Explore the universe of human proteins at neXtProt for KIR2DL1: NX_P43626

Explore proteomics data for KIR2DL1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn67, Asn84, Asn144, Asn178
  • Modification sites at PhosphoSitePlus

  • See KIR2DL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055033.2  
    ENSEMBL proteins: 
     ENSP00000336769   ENSP00000291633  
    Reactome Protein details: P43626

    KIR2DL1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for KIR2DL1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for KIR2DL1
    GenScript Custom Purified and Recombinant Proteins Services for KIR2DL1
    Novus Biologicals KIR2DL1 Proteins
    Novus Biologicals KIR2DL1 Lysates
    Sino Biological Recombinant Protein for KIR2DL1
    Sino Biological Cell Lysate for KIR2DL1
    ProSpec Recombinant Protein for KIR2DL1
    Cloud-Clone Corp. Proteins for KIR2DL1

    KIR2DL1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for KIR2DL1 (KIR2DL1/CD158a)
    OriGene Antibodies for KIR2DL1
    OriGene Custom Antibody Services for KIR2DL1
    Novus Biologicals KIR2DL1 Antibodies
    Abcam antibodies for KIR2DL1 (P43631, P43626, Q99706)
    Cloud-Clone Corp. Antibodies for KIR2DL1
    ThermoFisher Antibodies for KIR2DL1
    LSBio Antibodies in human, mouse, rat for KIR2DL1

    KIR2DL1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KIR2DL1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KIR2DL1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for KIR2DL1
    Cloud-Clone Corp. CLIAs for KIR2DL1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CD: CD molecules
    KIR: Killer cell immunoglobulin-like receptors
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    3 InterPro protein domains:
     IPR003599 Ig_sub
     IPR013783 Ig-like_fold
     IPR013151 Immunoglobulin

    Graphical View of Domain Structure for InterPro Entry P43626

    ProtoNet protein and cluster: P43626

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: KI2L1_HUMAN, P43626
    Similarity: Belongs to the immunoglobulin superfamily
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


    KIR2DL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KI2L1_HUMAN, P43626
    Function: Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus
    preventing cell lysis

         Genatlas biochemistry entry for KIR2DL1:
    natural killer cell immunoglobulin-like inhibitory receptor for HLA-C antigen,2DL1,58kDa

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS7749980
    GO:0005515protein binding IPI18604210
         
    KIR2DL1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KIR2DL1:
     Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KIR2DL1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KIR2DL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KIR2DL1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KIR2DL1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat KIR2DL1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate KIR2DL1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for KIR2DL1
    Predesigned siRNA for gene silencing in human, mouse, rat KIR2DL1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KIR2DL1

    Clone
    Products:
         
    OriGene clones in human, mouse for KIR2DL1 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KIR2DL1 (NM_014218)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KIR2DL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIR2DL1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KIR2DL1
    Browse ESI BIO Cell Lines and PureStem Progenitors for KIR2DL1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIR2DL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    KI2L1_HUMAN, P43626: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    chloroplast2
    extracellular2
    endoplasmic reticulum1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS7749980

    KIR2DL1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for KIR2DL1 About    
    See pathways by source

    SuperPathContained pathways About
    1Immune response Role of DAP12 receptors in NK cells
    Immune response Role of DAP12 receptors in NK cells0.33
    Natural killer cell mediated cytotoxicity0.31
    2Allograft rejection
    Graft-versus-host disease0.65
    Antigen processing and presentation0.36
    3Signaling by FGFR
    DAP12 interactions0.89
    4Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    5Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for KIR2DL1
        Immune response Role of DAP12 receptors in NK cells


    1 Reactome Pathway for KIR2DL1
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


    3 Kegg Pathways  (Kegg details for KIR2DL1):
        Antigen processing and presentation
    Natural killer cell mediated cytotoxicity
    Graft-versus-host disease


    KIR2DL1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KIR2DL1
    Interactions:

        GeneGlobe Interaction Network for KIR2DL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for KIR2DL1 (P436261, 2, 3 ENSP000003367694) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN6P293501, 2, 3, ENSP000003915924EBI-8684277,EBI-78260 MINT-8035707 MINT-8035722 MINT-8027477 MINT-8027492 I2D: score=2 STRING: ENSP00000391592
    PTPN11Q061242, 3, ENSP000003409444MINT-8027537 MINT-8027552 I2D: score=2 STRING: ENSP00000340944
    PIK3R1P279862, 3, ENSP000002743354MINT-8027522 MINT-8027507 I2D: score=1 STRING: ENSP00000274335
    HLA-CP103213, ENSP000003654024I2D: score=3 STRING: ENSP00000365402
    ARRB2P321213I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002769natural killer cell inhibitory signaling pathway IDA18604210
    GO:0006955immune response TAS7749980
    GO:0050776regulation of immune response TAS--

    KIR2DL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KIR2DL1 (KI2L1)

    2 Novoseek inferred chemical compound relationships for KIR2DL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lipid 0 3 11724921 (1), 12351398 (1)
    tyrosine 0 2 11034353 (1), 12351398 (1)



    KIR2DL1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for KIR2DL1 gene: 
    NM_014218.2  

    Unigene Cluster for KIR2DL1:

    Killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
    Hs.654605  [show with all ESTs]
    Unigene Representative Sequence: X93595
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336077(uc010erz.1 uc002qhb.1) ENST00000291633
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KIR2DL1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate KIR2DL1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for KIR2DL1
    Predesigned siRNA for gene silencing in human, mouse, rat KIR2DL1
    Clone
    Products:
         
    OriGene clones in human, mouse for KIR2DL1 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KIR2DL1 (NM_014218)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KIR2DL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIR2DL1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for KIR2DL1
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat KIR2DL1
      QuantiTect SYBR Green Assays in human, mouse, rat KIR2DL1
      QuantiFast Probe-based Assays in human, mouse, rat KIR2DL1

    Additional mRNA sequence: 

    AF022045.1 AF135558.1 AF135560.1 AF208683.1 AF208687.1 AF208690.1 AF262965.1 AF262966.1 
    AF262967.1 AF263617.1 AF285431.1 AF285432.1 AJ276125.1 AY059418.1 AY059419.1 AY059420.1 
    AY366237.1 AY366238.1 AY366239.1 AY366240.1 AY366241.1 AY366256.2 AY388471.1 AY789055.1 
    AY789056.1 AY789067.1 AY789068.1 AY789069.1 AY789070.1 AY789071.1 BC069344.1 DQ256504.1 
    EF582384.1 L41267.1 L41270.1 L76665.1 L76666.1 U24076.1 U24078.1 U30272.1 
    X93595.1 X93596.1 X94373.1 X94374.1 

    3 DOTS entries:

    DT.92058638  DT.86840863  DT.95344548 

    5 AceView cDNA sequences:

    L41268 BI909683 NM_153443 NM_014218 NM_014511 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    KIR2DL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KIR2DL1 Expression
    About this image


    KIR2DL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Natural Killer Cells Peripheral Blood
             Natural killer-like cells
    KIR2DL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KIR2DL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654605
        Custom PCR Arrays for KIR2DL1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for KIR2DL1
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat KIR2DL1
    QuantiTect SYBR Green Assays in human, mouse, rat KIR2DL1
    QuantiFast Probe-based Assays in human, mouse, rat KIR2DL1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIR2DL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for KIR2DL1 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    12(a)
    1 → many
    GL343329.1(1197670-1218701)
            Species with no ortholog for KIR2DL1

    ENSEMBL Gene Tree for KIR2DL1 (if available)
    TreeFam Gene Tree for KIR2DL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for KIR2DL1 gene
    KIR2DL31 2  LILRB42  KIR2DL42  LILRB12  KIR2DS42  LILRA62  LILRA52  IGSF12  
    KIR3DL12  OSCAR2  NCR12  LILRA42  ENSG000002177922  TARM12  KIR3DX12  LILRA32  
    LILRB52  KIR3DL32  LILRA12  KIR3DS12  LILRB22  A1BG2  KIR3DL22  LILRA22  
    FCAR2  GP62  LILRB32  
    Selected SIMAP similar genes for KIR2DL1 using alignment to 20 protein entries:     KI2L1_HUMAN (see all proteins) (see all similar genes):
    KIR-K3    KIR-K64    KIR2DP1DL1    KIR-G2    KIR-K9    KIR2DL2
    KIR2DS1    KIR412    KIR-K61    KIR-K65    KIR2DL3    KIR-K15
    KIR-K78    KIR221    KIR-K36    p58    KIR2DS2S3    KIR2DS

    KIR2DL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for KIR2DL1 (see all 355)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1867516351,2
    --55279335(+) TCATGG/TTTTCG 1 -- us2k10--------
    rs1905933971,2
    --55279373(+) CTTCCA/GTTATC 1 -- us2k10--------
    rs1831512061,2
    --55279399(+) TAACCA/CCATCT 1 -- us2k10--------
    rs1445817991,2
    --55279442(+) AGTTTC/GTGGAA 1 -- us2k10--------
    rs1863612891,2
    --55279510(+) ATAGGA/CGGTTC 1 -- us2k10--------
    rs1484081081,2
    --55279525(+) GATCGG/TGAATC 1 -- us2k10--------
    rs1425247971,2
    --55279601(+) AACATC/TTGTAG 1 -- us2k10--------
    rs1909138711,2
    --55279724(+) TGAACC/GGAGTA 1 -- us2k10--------
    rs1841015831,2
    --55279771(+) TACAAA/GAAGCA 1 -- us2k10--------
    rs1421069261,2
    --55279782(+) GAACTA/GTGTTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KIR2DL1 (55281263 - 55295778 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for KIR2DL1 (see all 42):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2667609CNV Deletion23128226
    esv2661467CNV Deletion23128226
    esv2421952CNV Deletion20811451
    esv2718927CNV Deletion23290073
    esv2718872CNV Deletion23290073
    dgv668e199CNV Deletion23128226
    nsv436250CNV Deletion17901297
    esv2718925CNV Deletion23290073
    dgv575e201CNV Deletion23290073
    dgv577e201CNV Deletion23290073

    Human Gene Mutation Database (HGMD): KIR2DL1
    Locus Specific Mutation Databases (LSDB): KIR2DL1

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KIR2DL1
    DNA2.0 Custom Variant and Variant Library Synthesis for KIR2DL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604936    OMIM disorders: --

    Selected diseases for KIR2DL1 (see all 57):    
    About MalaCards
    t-cell large granular lymphocyte leukemia    large granular lymphocyte leukemia    hematopoietic stem cell transplantation    birdshot chorioretinopathy
    microscopic polyangiitis    spondyloarthropathy    leptospirosis    psoriatic arthritis
    anterior uveitis    behcet's disease    vogt-koyanagi-harada disease    ankylosing spondylitis
    cutaneous t cell lymphoma    cytomegalovirus infection    tropical spastic paraparesis    spastic paraparesis
    recurrent respiratory papillomatosis    familial mediterranean fever    uveitis    cervical intraepithelial neoplasia


    KIR2DL1 for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for KIR2DL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma t-cell 40.6 3 11253136 (2)
    behcet disease 27.6 1 11229470 (1)
    autoimmune diseases 0 3 11229470 (2)
    rheumatoid arthritis 0 1 11229470 (1)
    tumors 0 4 11724921 (1), 15312339 (1), 12351398 (1)
    melanoma 0 1 16914567 (1)

    Genetic Association Database (GAD): KIR2DL1
    Human Genome Epidemiology (HuGE) Navigator: KIR2DL1 (103 documents)

    Export disorders for KIR2DL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for KIR2DL1 gene, integrated from 10 sources (see all 200):
    (articles sorted by number of sources associating them with KIR2DL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular clones of the p58 NK cell receptor reveal immunoglobulin- related molecules with diversity in both the extra- and intracellular domains. (PubMed id 7749980)1, 2, 3 Wagtmann N.... Long E.O. (Immunity 1995)
    2. Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. (PubMed id 7716543)1, 2, 3 Colonna M. and Samaridis J. (Science 1995)
    3. [Distribution of immunoglobulin like receptor gene in Han population in China and the impact thereof on the HLA-identical sibling hematopoietic stem cell transplantation]. (PubMed id 18269867)1, 4, 9 Dou L.P....Yu L. (Zhonghua Yi Xue Za Zhi 2007)
    4. [Differential expression levels of killer immunoglobin-like receptor genotype in patients with hematological malignancies between high-risk and standard-risk groups]. (PubMed id 18718052)1, 4, 9 Zhao X.Y....Huang X.J. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2008)
    5. Killer cell immunoglobulin-like receptor genotypes in Japanese patients with type 1 diabetes. (PubMed id 17990989)1, 4, 9 Mogami S....Nakamura N. (Tissue Antigens 2007)
    6. Comparison of killer Ig-like receptor genotyping and phenotyping for selection of allogeneic blood stem cell donors. (PubMed id 15879158)1, 4, 9 Leung W....Handgretinger R. (J. Immunol. 2005)
    7. HLA-C and KIR genes in hepatitis C virus infection. (PubMed id 16571411)1, 4, 9 Montes-Cano M.A....GonzA!lez-Escribano M.F. (Hum. Immunol. 2005)
    8. Association of killer cell immunoglobulin-like receptor 2DL5 with systemic lupus erythematosus and accompanying infections. (PubMed id 20371502)1, 4 Kimoto Y....Harada M. (Rheumatology (Oxford) 2010)
    9. Immunogenetic characteristics of patients with autoimmune gastritis. (PubMed id 20082482)1, 4 Oksanen A.M....Partanen J.A. (World J. Gastroenterol. 2010)
    10. Association of KIR2DS1 and KIR2DS3 with fatal outcome in Ebola virus infection. (PubMed id 20878400)1, 4 Wauquier N....Vieillard V. (Immunogenetics 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3802 HGNC: 6329 AceView: KIR2DL1 Ensembl:ENSG00000125498 euGenes: HUgn3802
    ECgene: KIR2DL1 Kegg: 3802 H-InvDB: KIR2DL1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for KIR2DL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for KIR2DL1 gene:
    Search GeneIP for patents involving KIR2DL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for KIR2DL1 (KIR2DL1/CD158a)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for KIR2DL1   OriGene RNAi products in human, mouse, rat for KIR2DL1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for KIR2DL1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for KIR2DL1  
     OriGene qSTAR qPCR primer pairs in human, mouse for KIR2DL1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KIR2DL1   OriGene Custom Protein Services for KIR2DL1  

     
     
     Block miRNA regulation of human, mouse, rat KIR2DL1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing KIR2DL1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KIR2DL1 Predesigned siRNA for gene silencing in human, mouse, rat KIR2DL1
     QuantiFast Probe-based Assays in human, mouse, rat KIR2DL1 QuantiTect SYBR Green Assays in human, mouse, rat KIR2DL1
     Custom PCR Arrays for KIR2DL1 Search Chromatin IP Primers for KIR2DL1
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat KIR2DL1  GeneGlobe Interaction Network for KIR2DL1
     Regulatory tfbs in KIR2DL1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for KIR2DL1 GenScript cDNA clones with any tag delivered in your preferred vector for KIR2DL1
     GenScript Custom Assay Services for KIR2DL1 GenScript Custom overexpressing Cell Line Services for KIR2DL1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for KIR2DL1 (KI2L1)
     Proteins for KIR2DL1
     Cell Lysates for KIR2DL1
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     KIR2DL1 antibodies
     KIR2DL1 proteins
     KIR2DL1 lysates
     Antibodies for KIR2DL1
     See all of Abcam's Antibodies, Kits and Proteins for KIR2DL1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for KIR2DL1
     Proteins for KIR2DL1
     Antibodies for KIR2DL1
     ELISAs for KIR2DL1
     CLIAs for KIR2DL1



     Browse ESI BIO Cell Lines and PureStem Progenitors for KIR2DL1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIR2DL1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for KIR2DL1
     SwitchGear Promoter luciferase reporter plasmids for KIR2DL1
     ThermoFisher Antibodies for KIR2DL1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIR2DL1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KIR2DL1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KIR2DL1
     LSBio Antibodies in human, mouse, rat for KIR2DL1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KIR2DL1 gene at Home site.
    Version: 3.12.162 20 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4