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KIN Gene

protein-coding   GIFtS: 57
GCID: GC10M007795

KIN, Antigenic Determinant Of RecA Protein Homolog (Mouse)

(Previous name: antigenic determinant of recA protein (mouse) homolog)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
KIN, Antigenic Determinant Of RecA Protein Homolog (Mouse)1 2     Antigenic Determinant Of RecA Protein (Mouse) Homolog1
BTCD2 3 5     DNA/RNA-Binding Protein KIN172
KIN172 3 5     KIN, Antigenic Determinant Of RecA Protein Homolog3
Binding To Curved DNA2 3     

External Ids:    HGNC: 63271   Entrez Gene: 229442   Ensembl: ENSG000001516577   OMIM: 6017205   UniProtKB: O608703   

Export aliases for KIN gene to outside databases

Previous GC identifers: GC10M007741 GC10M007945 GC10M007801 GC10M007837 GC10M007715


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KIN Gene:
The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is
redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization
of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on
protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of
the bacterial RecA protein, a characteristic shared by this human ortholog. Alternative splicing of this gene
results in multiple transcript variants. (provided by RefSeq, Jan 2012)

GeneCards Summary for KIN Gene:
KIN (KIN, antigenic determinant of recA protein homolog (mouse)) is a protein-coding gene. Diseases associated with KIN include cheilitis, and actinic keratosis. GO annotations related to this gene include double-stranded DNA binding and RNA binding.

UniProtKB/Swiss-Prot: KIN17_HUMAN, O60870
Function: Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication
factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May
play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing.
Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By
similarity). Binds via its C-terminal domain to RNA in vitro

Gene Wiki entry for KIN Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_008705.17  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KIN gene promoter:
         TBP   PPAR-gamma1   Elk-1   AML1a   Pbx1a   ATF-2   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKIN promoter sequence
   Search Chromatin IP Primers for KIN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KIN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p15-p14   Ensembl cytogenetic band:  10p14   HGNC cytogenetic band: 10p15-p14

KIN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIN gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M007795:  view genomic region     (about GC identifiers)

Start:
7,792,925 bp from pter      End:
7,829,990 bp from pter
Size:
37,066 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: KIN17_HUMAN, O60870 (See protein sequence)
Recommended Name: DNA/RNA-binding protein KIN17  
Size: 393 amino acids; 45374 Da
Subunit: Interacts with SV40 large T antigen. Associated with DNA polymerase alpha, RFC1 and cyclin A, in
multiprotein DNA replication complexes. Also associates with replication origins at the G1/S phase boundary and
throughout the S phase in vivo
Miscellaneous: Recognized by antibodies directed against the RecA protein (By similarity)
2 PDB 3D structures from and Proteopedia for KIN:
2CKK (3D)        2V1N (3D)    

Explore the universe of human proteins at neXtProt for KIN: NX_O60870

Explore proteomics data for KIN at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KIN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036443.1  
    ENSEMBL proteins: 
     ENSP00000368881   ENSP00000473950   ENSP00000440529   ENSP00000440390  

    KIN Human Recombinant Protein Products:

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    Novus Biologicals KIN Proteins
    Novus Biologicals KIN Lysate
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    Cloud-Clone Corp. Proteins for KIN

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    LSBio Antibodies in human, mouse, rat for KIN

    KIN Assay Products:

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    Cloud-Clone Corp. CLIAs for KIN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR019447 DNA/RNA-bd_Kin17_cons_domain

    Graphical View of Domain Structure for InterPro Entry O60870

    ProtoNet protein and cluster: O60870

    1 Blocks protein domain: IPB006646 KOW (Kyprides

    UniProtKB/Swiss-Prot: KIN17_HUMAN, O60870
    Domain: The C-terminal domain (268-393) is organized into 2 subdomains that bear structural similarities to
    SH3-like domains. Both subdomains adopt a similar 5-stranded beta-barrel-like fold and are connected to each
    other by a short linker of 5 residues. The 5 beta-sheets are packed at approximately right angles against each
    other. A highly conserved groove formed at the interface between the 2 subdomains, comprised of Lys residues 302
    and 391 and other positively charged residues, may possibly be the site of RNA-binding
    Similarity: Belongs to the KIN17 family
    Similarity: Contains 1 C2H2-type zinc finger


    KIN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KIN17_HUMAN, O60870
    Function: Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication
    factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May
    play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing.
    Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By
    similarity). Binds via its C-terminal domain to RNA in vitro
    Induction: By UVC irradiation in quiescent primary fibroblasts. By mitomycin C in human melanoma MeWO cells

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS1923796
    GO:0003690double-stranded DNA binding ISS--
    GO:0003723RNA binding IDA17045609
    GO:0046872metal ion binding IEA--
         
    KIN for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KIN
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KIN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KIN

    miRNA
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    miRTarBase miRNAs that target KIN:
    hsa-mir-16-5p (MIRT032026)

    Block miRNA regulation of human, mouse, rat KIN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KIN (see all 15):
    hsa-miR-21* hsa-miR-495 hsa-miR-607 hsa-miR-520d-5p hsa-miR-300 hsa-miR-7-2* hsa-miR-381 hsa-miR-4282
    SwitchGear 3'UTR luciferase reporter plasmidKIN 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for KIN
    Predesigned siRNA for gene silencing in human, mouse, rat KIN

    Gene Editing
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    OriGene ORF clones in mouse, rat for KIN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KIN (NM_012311)
    Sino Biological Human cDNA Clone for KIN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KIN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIN

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KIN17_HUMAN, O60870: Nucleus. Cytoplasm. Note=During S phase, strongly associated with the nuclear matrix, and to
    chromosomal DNA in the presence of DNA damage. Also shows cytoplasmic localization in elongated spermatids
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS1923796
    GO:0005737cytoplasm IEA--
    GO:0016363nuclear matrix IDA12754299

    KIN for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KIN
    Interactions:

        Search GeneGlobe Interaction Network for KIN

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for KIN (O608702, 3 ENSP000003688814) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPA2P159273, ENSP000003630214I2D: score=1 STRING: ENSP00000363021
    RPA1P276943, ENSP000002547194I2D: score=1 STRING: ENSP00000254719
    BUD13Q9BRD03I2D: score=5 
    PABPC4Q133103I2D: score=5 
    RBL1P287493I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication IDA12359749
    GO:0006281DNA repair IEA--
    GO:0006310DNA recombination IEA--
    GO:0006397mRNA processing TAS17045609
    GO:0006974cellular response to DNA damage stimulus IEP12853634

    KIN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KIN (KIN17)

    2 Novoseek inferred chemical compound relationships for KIN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mimosine 77.3 1 12853634 (1)
    zinc 27.9 2 1923796 (1), 9466698 (1)



    KIN for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KIN gene: 
    NM_012311.3  

    Unigene Cluster for KIN:

    KIN, antigenic determinant of recA protein homolog (mouse)
    Hs.397918  [show with all ESTs]
    Unigene Representative Sequence: NM_012311
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379562(uc001ijt.3) ENST00000498098 ENST00000463666 ENST00000471320
    ENST00000460089 ENST00000535925(uc010qaz.2) ENST00000543003(uc010qba.2)


    miRNA
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    Block miRNA regulation of human, mouse, rat KIN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KIN (see all 15):
    hsa-miR-21* hsa-miR-495 hsa-miR-607 hsa-miR-520d-5p hsa-miR-300 hsa-miR-7-2* hsa-miR-381 hsa-miR-4282
    SwitchGear 3'UTR luciferase reporter plasmidKIN 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KIN
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KIN (NM_012311)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KIN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIN
    Primer
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    OriGene qPCR primer pairs and template standards for KIN
    OriGene qSTAR qPCR primer pairs in human, mouse for KIN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KIN
      QuantiTect SYBR Green Assays in human, mouse, rat KIN
      QuantiFast Probe-based Assays in human, mouse, rat KIN

    Additional mRNA sequence: 

    AJ005273.1 AK296637.1 AK309059.1 BC017309.2 BC037913.2 NR_045609.1 

    10 DOTS entries:

    DT.206218  DT.91996611  DT.40287372  DT.436428  DT.100751134  DT.100751136  DT.40125534  DT.92420255 
    DT.92440073  DT.95149006 

    Selected AceView cDNA sequences (see all 101):

    BM453332 BM689918 BQ130494 NM_012311 R92811 CD109094 CR595908 BU161074 
    CB269659 CR618602 BG943319 BM782457 BM711163 BM759166 CB158644 AA827733 
    BQ221694 AA768850 BC037913 AA770446 BG676860 AL700007 BM740267 CF596826 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KIN (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c
    SP1:                          -                                                                                                         
    SP2:                    -     -                                                                                                         
    SP3:                                                                          -     -                                                   
    SP4:                                                                                            -                                       
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for KIN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KIN expression in normal human tissues (normalized intensities)      KIN embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGTATCAAA
    KIN Expression
    About this image


    KIN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Eye (Sensory Organs)
             Retina
    KIN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KIN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.397918

    UniProtKB/Swiss-Prot: KIN17_HUMAN, O60870
    Tissue specificity: Ubiquitously expressed in all tissues examined, with highest levels in skeletal muscle, heart
    and testis. Differentially expressed in non-tumorigenic and tumorigenic cell lines. Highly expressed in
    proliferating epithelial keratinocyte cells in vitro (at protein level)

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for KIN gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kin1 , 5 antigenic determinant of rec-A protein1, 5 85.85(n)1
    92.07(a)1
      2 (6.88 cM)5
    165881  NM_025280.21  NP_079556.11 
     100805935 
    chicken
    (Gallus gallus)
    Aves KIN1 KIN, antigenic determinant of recA protein homolog more 81.41(n)
    88.17(a)
      419109  XM_004937483.1  XP_004937540.1 
    lizard
    (Anolis carolinensis)
    Reptilia KIN6
    KIN, antigenic determinant of recA protein homolog...
    84(a)
    1 ↔ 1
    5(192408-205436)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.68062 Xenopus laevis transcribed sequence with moderate similarity more 78.68(n)    BX846650.1 
    zebrafish
    (Danio rerio)
    Actinopterygii kin1 KIN, antigenic determinant of recA protein homolog more 70.14(n)
    77.08(a)
      555316  NM_001030086.2  NP_001025257.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta kin171 , 3 DNA binding3
    kin171
    58(a)3
    55.67(n)1
    52.88(a)1
      77B53
    402421  NM_140955.41  NP_649212.21 
    worm
    (Caenorhabditis elegans)
    Secernentea Y52B11A.93
    CELE_Y52B11A.91
    CELE_Y52B11A.91 45(a)3
    50.47(n)1
    47.56(a)1
      I(11042149-11046876)3
    1730051  NM_060459.31  NP_492860.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RTS2(YOR077W)4 Basic zinc-finger protein, similar to human and mouse more   --   15(471899-472597) 854244  NP_014720.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G554601 AT1G55460 54.21(n)
    50.77(a)
      841993  NM_104422.1  NP_564690.1 
    rice
    (Oryza sativa)
    Liliopsida Os.209772 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 77.14(n)    AK069396.1 


    ENSEMBL Gene Tree for KIN (if available)
    TreeFam Gene Tree for KIN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KIN (see all 840)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs349696041,2
    C--7734818(+) AAAAA-/AATGCCT 1 -- int11Minor allele frequency- AA:0.00NA 2
    rs1856431641,2
    --7792457(+) CCTTTC/GACTAT 2 -- ds50010--------
    rs736284651,2
    C,F--7792468(+) TAGACG/AAGGCC 2 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1826192771,2
    --7792482(+) CCACAC/TAAGGG 2 -- ds50010--------
    rs736284661,2
    C,F--7792525(+) GAGATG/AGGGTC 2 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1120662491,2
    C,F--7792595(+) CTCCCG/AGGTTC 2 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1921541041,2
    --7792652(+) GTGAGC/TCACCA 2 -- ds50010--------
    rs1175258211,2
    C,F--7792749(+) TACACA/GTTGTT 2 -- ds50011Minor allele frequency- G:0.03NA 120
    rs1421333201,2
    C--7792751(+) CACATG/TGTTAA 2 -- ds50010--------
    rs1835248451,2
    --7792757(+) GTTAAC/TGTTGC 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for KIN (7792925 - 7829990 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for KIN:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2732417CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KIN
    DNA2.0 Custom Variant and Variant Library Synthesis for KIN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601720    OMIM disorders: --

    7 diseases for KIN:    About MalaCards
    cheilitis    actinic keratosis    keratosis    melanoma
    alzheimer's disease    malaria    breast cancer


    KIN for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for KIN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 13.5 2 12751957 (1), 11604067 (1)
    tumors 0 2 12751957 (1), 11604067 (1)

    Genetic Association Database (GAD): KIN
    Human Genome Epidemiology (HuGE) Navigator: KIN (22 documents)

    Export disorders for KIN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KIN gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with KIN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Selective interactions of human kin17 and RPA proteins with chromatin and the nuclear matrix in a DNA damage- and cell cycle-regulated manner. (PubMed id 12853634)1, 2, 9 Miccoli L.... Angulo J.F. (Nucleic Acids Res. 2003)
    2. The human stress-activated protein kin17 belongs to the multiprotein DNA replication complex and associates in vivo with mammalian replication origins. (PubMed id 15831485)1, 2, 9 Miccoli L.... Angulo J.F. (Mol. Cell. Biol. 2005)
    3. Identification and expression of the cDNA of KIN17, a zinc-finger gene located on mouse chromosome 2, encoding a new DNA-binding protein. (PubMed id 1923796)1, 3, 9 Angulo J.F....Devoret R. (Nucleic Acids Res. 1991)
    4. Human kin17 protein directly interacts with the simian virus 40 large T antigen and inhibits DNA replication. (PubMed id 12359749)1, 2, 9 Miccoli L.... Angulo J.F. (Cancer Res. 2002)
    5. Global genome repair is required to activate KIN17, a UVC-responsive gene involved in DNA replication. (PubMed id 12525703)1, 2, 9 Masson C.... Angulo J.F. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    6. Molecular cloning and characterization of the human KIN17 cDNA encoding a component of the UVC response that is conserved among metazoans. (PubMed id 10964102)1, 2, 9 Kannouche P.... Angulo J.F. (Carcinogenesis 2000)
    7. Differential expression of the HsKin17 protein during differentiation of in vitro reconstructed human skin. (PubMed id 9266022)1, 2, 9 Biard D.S.F.... Angulo J.F. (Arch. Dermatol. Res. 1997)
    8. Participation of kin17 protein in replication factories and in other DNA transactions mediated by high molecular weight nuclear complexes. (PubMed id 12754299)1, 2, 9 Biard D.S.F.... Angulo J.F. (Mol. Cancer Res. 2003)
    9. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1, 2 Cloutier P.... Coulombe B. (PLoS Genet. 2013)
    10. A tandem of SH3-like domains participates in RNA binding in KIN17, a human protein activated in response to genotoxics. (PubMed id 17045609)1, 2 le Maire A.... Zinn-Justin S. (J. Mol. Biol. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 22944 HGNC: 6327 AceView: KIN Ensembl:ENSG00000151657 euGenes: HUgn22944
    ECgene: KIN H-InvDB: KIN

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KIN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for KIN gene:
    Search GeneIP for patents involving KIN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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