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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KIN Gene

protein-coding   GIFtS: 52
GCID: GC10M007795

KIN, antigenic determinant of recA protein homolog (mouse)

(Previous name: antigenic determinant of recA protein (mouse) homolog )
 Explore 7 diseases affiliated with
KIN via our new
 Human Malady Compendium 
Biological research products
for KIN
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
KIN, Antigenic Determinant Of RecA Protein Homolog (Mouse)1 2     Antigenic Determinant Of RecA Protein (Mouse) Homolog1
KIN171 2 3 5     DNA/RNA-Binding Protein KIN172
BTCD2 3 5     KIN, Antigenic Determinant Of RecA Protein Homolog3
Binding To Curved DNA2 3     

External Ids:    HGNC: 63271   Entrez Gene: 229442   Ensembl: ENSG000001516577   OMIM: 6017205   UniProtKB: O608703   

Export aliases for KIN gene to outside databases

Previous GC identifers: GC10M007741 GC10M007945 GC10M007801 GC10M007837 GC10M007715


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KIN:
The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is
redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of
the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on
protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the
bacterial RecA protein, a characteristic shared by this human ortholog. Alternative splicing of this gene results in
multiple transcript variants. (provided by RefSeq, Jan 2012)

UniProtKB/Swiss-Prot: KIN17_HUMAN, O60870
Function: Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication
factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play
a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in
vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity).
Binds via its C-terminal domain to RNA in vitro

Gene Wiki entry for KIN


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_008705.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KIN gene promoter:
         TBP   PPAR-gamma1   Elk-1   AML1a   Pbx1a   ATF-2   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKIN promoter sequence
   Search SABiosciences Chromatin IP Primers for KIN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p15-p14   Ensembl cytogenetic band:  10p14   HGNC cytogenetic band: 10p15-p14

KIN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIN gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M007795:  view genomic region     (about GC identifiers)

Start:
7,795,188 bp from pter      End:
7,829,990 bp from pter
Size:
34,803 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KIN17_HUMAN, O60870 (See protein sequence)
Recommended Name: DNA/RNA-binding protein KIN17  
Size: 393 amino acids; 45374 Da
Subunit: Interacts with SV40 large T antigen. Associated with DNA polymerase alpha, RFC1 and cyclin A, in multiprotein
DNA replication complexes. Also associates with replication origins at the G1/S phase boundary and throughout the S
phase in vivo
Subcellular location: Nucleus. Cytoplasm. Note=During S phase, strongly associated with the nuclear matrix, and to
chromosomal DNA in the presence of DNA damage. Also shows cytoplasmic localization in elongated spermatids
Miscellaneous: Recognized by antibodies directed against the RecA protein (By similarity)
2 PDB 3D structures from and Proteopedia for KIN:
2CKK (3D)        2V1N (3D)    

Explore the universe of human proteins at neXtProt for KIN: NX_O60870

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O60870

  • KIN Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_036443.1  
    ENSEMBL proteins: 
     ENSP00000368881   ENSP00000440529   ENSP00000440390  

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    Novus Biologicals KIN Protein
    Novus Biologicals KIN Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for KIN

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus TAS1923796
    GO:0005737cytoplasm IEA--
    GO:0016363nuclear matrix IDA12754299


    KIN for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    KIN for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR019447 DNA/RNA-bd_Kin17_cons_domain

    Graphical View of Domain Structure for InterPro Entry O60870

    ProtoNet protein and cluster: O60870

    1 Blocks protein family: IPB006646 KOW (Kyprides

    UniProtKB/Swiss-Prot: KIN17_HUMAN, O60870
    Domain: The C-terminal domain (268-393) is organized into 2 subdomains that bear structural similarities to SH3-like
    domains. Both subdomains adopt a similar 5-stranded beta-barrel-like fold and are connected to each other by a short
    linker of 5 residues. The 5 beta-sheets are packed at approximately right angles against each other. A highly
    conserved groove formed at the interface between the 2 subdomains, comprised of Lys residues 302 and 391 and other
    positively charged residues, may possibly be the site of RNA-binding
    Similarity: Belongs to the KIN17 family
    Similarity: Contains 1 C2H2-type zinc finger


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: KIN17_HUMAN, O60870
    Function: Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication
    factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play
    a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in
    vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity).
    Binds via its C-terminal domain to RNA in vitro
    Induction: By UVC irradiation in quiescent primary fibroblasts. By mitomycin C in human melanoma MeWO cells

    miRNA
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    hsa-miR-21* hsa-miR-495 hsa-miR-607 hsa-miR-520d-5p hsa-miR-300 hsa-miR-7-2* hsa-miR-381 hsa-miR-4282
    SwitchGear 3'UTR luciferase reporter plasmidKIN 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS1923796
    GO:0003690double-stranded DNA binding ISS--
    GO:0003723RNA binding IDA17045609
    GO:0008270zinc ion binding IEA--


    KIN for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIN

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/8 Interacting proteins for KIN (O608702, 3 ENSP000003688814) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPA2P159273, ENSP000003630214I2D: score=1 STRING: ENSP00000363021
    RPA1P276943, ENSP000002547194I2D: score=1 STRING: ENSP00000254719
    BUD13Q9BRD03I2D: score=5 
    PABPC4Q133103I2D: score=5 
    RBL1P287493I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication IDA12359749
    GO:0006281DNA repair IEA--
    GO:0006310DNA recombination IEA--
    GO:0006397mRNA processing TAS17045609
    GO:0006974response to DNA damage stimulus IEP12853634


    KIN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KIN for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KIN
    2 Novoseek chemical compound relationships for KIN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mimosine 77.3 1 12853634 (1)
    zinc 27.9 2 1923796 (1), 9466698 (1)

    Search CenterWatch for drugs/clinical trials and news about KIN / KIN17 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KIN gene: 
    NM_012311.3  

    Unigene Cluster for KIN:

    KIN, antigenic determinant of recA protein homolog (mouse)
    Hs.397918  [show with all ESTs]
    Unigene Representative Sequence: NM_012311
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000498098 ENST00000379562(uc001ijt.3) ENST00000463666 ENST00000471320
    ENST00000460089 ENST00000535925(uc010qaz.2) ENST00000543003(uc010qba.2)


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    hsa-miR-21* hsa-miR-495 hsa-miR-607 hsa-miR-520d-5p hsa-miR-300 hsa-miR-7-2* hsa-miR-381 hsa-miR-4282
    SwitchGear 3'UTR luciferase reporter plasmidKIN 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KIN (see all 7)
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIN
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    Additional cDNA sequence: 

    AJ005273.1 AK296637.1 AK309059.1 BC017309.2 BC037913.2 NR_045609.1 

    10 DOTS entries:

    DT.206218  DT.91996611  DT.40287372  DT.436428  DT.100751134  DT.100751136  DT.40125534  DT.92420255 
    DT.92440073  DT.95149006 

    24/101 AceView cDNA sequences (see all 101):

    CD109094 R92811 BU161074 BM711163 NM_012311 CR618602 CR595908 BM759166 
    AA827733 BQ221694 BM689918 BM782457 BM453332 BQ130494 CB269659 BG943319 
    CB158644 BE894105 BI820591 AW089573 AV660661 AA770446 CK003350 AL700007 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for KIN (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c
    SP1:                          -                                                                                                         
    SP2:                    -     -                                                                                                         
    SP3:                                                                          -     -                                                   
    SP4:                                                                                            -                                       
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for KIN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KIN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGGTATCAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See KIN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KIN

    SOURCE GeneReport for Unigene cluster: Hs.397918

    UniProtKB/Swiss-Prot: KIN17_HUMAN, O60870
    Tissue specificity: Ubiquitously expressed in all tissues examined, with highest levels in skeletal muscle, heart and
    testis. Differentially expressed in non-tumorigenic and tumorigenic cell lines. Highly expressed in proliferating
    epithelial keratinocyte cells in vitro (at protein level)

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for KIN gene from 10/36 species (see all 36)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kin1 , 5 antigenic determinant of rec-A protein1, 5 86.36(n)1
    92.84(a)1
      2 (6.88 cM)5
    165881  NM_025280.21  NP_079556.11 
     100805935 
    chicken
    (Gallus gallus)
    Aves KIN1 KIN, antigenic determinant of recA protein homolog more 81.54(n)
    88.97(a)
      419109  XM_417297.3  XP_417297.3 
    lizard
    (Anolis carolinensis)
    Reptilia KIN6
    --
    84(a)
    1 ↔ 1
    5(192341-201521)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.68062 Xenopus laevis transcribed sequence with moderate similarity more 78.68(n)    BX846650.1 
    zebrafish
    (Danio rerio)
    Actinopterygii kin1 KIN, antigenic determinant of recA protein homolog more 70.49(n)
    77.34(a)
      555316  NM_001030086.2  NP_001025257.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta kin171 , 3 DNA binding3
    CG5649-PA1
    58(a)3
    54.97(n)1
    53.4(a)1
      77B53
    402421  NM_140955.31  NP_649212.21 
    worm
    (Caenorhabditis elegans)
    Secernentea Y52B11A.93
    CELE_Y52B11A.91
    Protein Y52B11A.91 45(a)3
    52.1(n)1
    49.61(a)1
      I(11042149-11046876)3
    1730051  NM_060459.21  NP_492860.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RTS2(YOR077W)4
    RTS21
    Basic zinc-finger protein, similar to human and mouse more4
    Rts2p1
    46.63(n)1
    36.52(a)1
      15(471899-472597)4
    8542441, 4  NP_014720.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G554601 DNA/RNA-binding protein Kin17 conserved region-containing more 54.1(n)
    51.54(a)
      841993  NM_104422.1  NP_564690.1 
    rice
    (Oryza sativa)
    Liliopsida Os.209772 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 77.14(n)    AK069396.1 


    ENSEMBL Gene Tree for KIN (if available)
    TreeFam Gene Tree for KIN (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/703 NCBI SNPs in KIN are shown (see all 703    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1856431641,2
    --7792457(+) CCTTTC/GACTAT 2 -- ds50010--------
    rs736284651,2
    C,--7792468(+) TAGACG/AAGGCC 2 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1826192771,2
    --7792482(+) CCACAC/TAAGGG 2 -- ds50010--------
    rs736284661,2
    C,--7792525(+) GAGATG/AGGGTC 2 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1120662491,2
    C,--7792595(+) CTCCCG/AGGTTC 2 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1921541041,2
    --7792652(+) GTGAGC/TCACCA 2 -- ds50010--------
    rs1175258211,2
    C,F,--7792749(+) TACACA/GTNNNN 2 -- ds50011Minor allele frequency- G:0.03NA 120
    rs1421333201,2
    --7792751(+) CACATG/TGTTAA 2 -- ds50010--------
    rs1835248451,2
    --7792757(+) GTTAAC/TGTTGC 2 -- ds50010--------
    rs47492311,2
    H--7792793(+) AAATTC/TTCTGG 2 -- ds50014Minor allele frequency- T:0.00NS EA 412

    HapMap Linkage Disequilibrium report for KIN (7795188 - 7829990 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for KIN: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    KIN for disorders           About GeneDecksing

    OMIM gene information: 601720    OMIM disorders: --

    7 diseases for KIN:    About MalaCards
    actinic keratosis    cheilitis    keratosis    alzheimer's disease
    melanoma    breast cancer    malaria

    2 Novoseek disease relationships for KIN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 13.5 2 12751957 (1), 11604067 (1)
    tumors 0 2 12751957 (1), 11604067 (1)

    Human Genome Epidemiology (HuGE) Navigator: KIN (22 documents)

    Export disorders for KIN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KIN gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with KIN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Selective interactions of human kin17 and RPA proteins with chromatin and the nuclear matrix in a DNA damage- and cell cycle-regulated manner. (PubMed id 12853634)1, 2, 9 Miccoli L.... Angulo J.F. (2003)
    2. The human stress-activated protein kin17 belongs to the multiprotein DNA replication complex and associates in vivo with mammalian replication origins. (PubMed id 15831485)1, 2, 9 Miccoli L.... Angulo J.F. (2005)
    3. Identification and expression of the cDNA of KIN17, a zinc-finger gene located on mouse chromosome 2, encoding a new DNA-binding protein. (PubMed id 1923796)1, 3, 9 Angulo J.F....Devoret R. (1991)
    4. Human kin17 protein directly interacts with the simian virus 40 large T antigen and inhibits DNA replication. (PubMed id 12359749)1, 2, 9 Miccoli L.... Angulo J.F. (2002)
    5. Global genome repair is required to activate KIN17, a UVC-responsive gene involved in DNA replication. (PubMed id 12525703)1, 2, 9 Masson C.... Angulo J.F. (2003)
    6. Molecular cloning and characterization of the human KIN17 cDNA encoding a component of the UVC response that is conserved among metazoans. (PubMed id 10964102)1, 2, 9 Kannouche P.... Angulo J.F. (2000)
    7. Differential expression of the HsKin17 protein during differentiation of in vitro reconstructed human skin. (PubMed id 9266022)1, 2, 9 Biard D.S.F.... Angulo J.F. (1997)
    8. Participation of kin17 protein in replication factories and in other DNA transactions mediated by high molecular weight nuclear complexes. (PubMed id 12754299)1, 2, 9 Biard D.S.F.... Angulo J.F. (2003)
    9. A tandem of SH3-like domains participates in RNA binding in KIN17, a human protein activated in response to genotoxics. (PubMed id 17045609)1, 2 le Maire A.... Zinn-Justin S. (2006)
    10. Ionizing radiation triggers chromatin-bound kin17 complex formation in human cells. (PubMed id 11880372)1, 2 Biard D.S.F....Angulo J.F. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22944 HGNC: 6327 AceView: KIN Ensembl:ENSG00000151657 euGenes: HUgn22944
    ECgene: KIN H-InvDB: KIN

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KIN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KIN gene:
    Search GeneIP for patents involving KIN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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