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Aliases for KIN Gene

Aliases for KIN Gene

  • Kin17 DNA And RNA Binding Protein 2 3 5
  • KIN, Antigenic Determinant Of RecA Protein Homolog 3 4
  • Binding To Curved DNA 3 4
  • KIN17 3 4
  • BTCD 3 4
  • KIN, Antigenic Determinant Of RecA Protein Homolog (Mouse) 2
  • Antigenic Determinant Of RecA Protein (Mouse) Homolog 2
  • DNA/RNA-Binding Protein KIN17 3
  • Rts2 3

External Ids for KIN Gene

Previous GeneCards Identifiers for KIN Gene

  • GC10M007741
  • GC10M007945
  • GC10M007801
  • GC10M007837
  • GC10M007715
  • GC10M007795

Summaries for KIN Gene

Entrez Gene Summary for KIN Gene

  • The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

GeneCards Summary for KIN Gene

KIN (Kin17 DNA And RNA Binding Protein) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Protein methylation. Gene Ontology (GO) annotations related to this gene include RNA binding and double-stranded DNA binding.

UniProtKB/Swiss-Prot for KIN Gene

  • Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity). Binds via its C-terminal domain to RNA in vitro.

Gene Wiki entry for KIN Gene

Additional gene information for KIN Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIN Gene

Genomics for KIN Gene

GeneHancer (GH) Regulatory Elements for KIN Gene

Promoters and enhancers for KIN Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I007786 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 560.6 -0.8 -769 4.2 HDGF PKNOX1 SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B ATP5F1C KIN ITIH2 GC10M007790
GH10I008049 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 66 -269.0 -269022 16 HDGF PKNOX1 FOXA2 MLX SIN3A FEZF1 ZNF2 ZNF213 E2F8 ZNF143 GATA3 KIN TAF3 SFMBT2 GATA3-AS1 ENSG00000232638 GC10P008092 GC10M008036 GC10M008037
GH10I007406 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 18.7 +378.8 378819 5 PKNOX1 SMAD1 SIN3A FEZF1 ZNF2 ZBTB7B YY1 ZNF302 ZNF143 ZNF207 SFMBT2 KIN TAF3 ENSG00000278982 GC10P007374
GH10I008702 Enhancer 0.9 ENCODE 38.5 -914.8 -914798 1.6 PKNOX1 SIN3A FEZF1 ZNF2 ZNF121 ZNF213 ZNF302 KLF7 ZNF548 FOS KIN TAF3 GC10P008711 GC10M008656 RNA5SP299 LOC105376400
GH10I007026 Enhancer 1.4 Ensembl ENCODE dbSUPER 19.5 +758.9 758938 4.4 HDGF PKNOX1 SMAD1 ATF1 ARNT NCOA2 TCF12 ZNF766 GATA2 FOS KIN RBM17 GC10M006973 LOC105376386 LOC105376387 GC10P006679
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KIN on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KIN gene promoter:

Genomic Locations for KIN Gene

Genomic Locations for KIN Gene
chr10:7,750,962-7,788,027
(GRCh38/hg38)
Size:
37,066 bases
Orientation:
Minus strand
chr10:7,792,925-7,829,990
(GRCh37/hg19)

Genomic View for KIN Gene

Genes around KIN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIN Gene

Proteins for KIN Gene

  • Protein details for KIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60870-KIN17_HUMAN
    Recommended name:
    DNA/RNA-binding protein KIN17
    Protein Accession:
    O60870
    Secondary Accessions:
    • B4DX32

    Protein attributes for KIN Gene

    Size:
    393 amino acids
    Molecular mass:
    45374 Da
    Quaternary structure:
    • Interacts with SV40 large T antigen. Associated with DNA polymerase alpha, RFC1 and cyclin A, in multiprotein DNA replication complexes. Also associates with replication origins at the G1/S phase boundary and throughout the S phase in vivo.
    Miscellaneous:
    • Recognized by antibodies directed against the RecA protein.

    Three dimensional structures from OCA and Proteopedia for KIN Gene

    Alternative splice isoforms for KIN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIN Gene

Post-translational modifications for KIN Gene

No Post-translational modifications

Other Protein References for KIN Gene

No data available for DME Specific Peptides for KIN Gene

Domains & Families for KIN Gene

Gene Families for KIN Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

O60870

UniProtKB/Swiss-Prot:

KIN17_HUMAN :
  • The C-terminal domain (268-393) is organized into 2 subdomains that bear structural similarities to SH3-like domains. Both subdomains adopt a similar 5-stranded beta-barrel-like fold and are connected to each other by a short linker of 5 residues. The 5 beta-sheets are packed at approximately right angles against each other. A highly conserved groove formed at the interface between the 2 subdomains, comprised of Lys residues 302 and 391 and other positively charged residues, may possibly be the site of RNA-binding.
  • Belongs to the KIN17 family.
Domain:
  • The C-terminal domain (268-393) is organized into 2 subdomains that bear structural similarities to SH3-like domains. Both subdomains adopt a similar 5-stranded beta-barrel-like fold and are connected to each other by a short linker of 5 residues. The 5 beta-sheets are packed at approximately right angles against each other. A highly conserved groove formed at the interface between the 2 subdomains, comprised of Lys residues 302 and 391 and other positively charged residues, may possibly be the site of RNA-binding.
Family:
  • Belongs to the KIN17 family.
genes like me logo Genes that share domains with KIN: view

Function for KIN Gene

Molecular function for KIN Gene

UniProtKB/Swiss-Prot Function:
Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity). Binds via its C-terminal domain to RNA in vitro.
UniProtKB/Swiss-Prot Induction:
By UVC irradiation in quiescent primary fibroblasts. By mitomycin C in human melanoma MeWO cells.

Phenotypes From GWAS Catalog for KIN Gene

Gene Ontology (GO) - Molecular Function for KIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 1923796
GO:0003690 double-stranded DNA binding ISS,IEA --
GO:0003723 RNA binding IDA,IEA 17045609
GO:0005515 protein binding IPI 23349634
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with KIN: view
genes like me logo Genes that share phenotypes with KIN: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIN Gene

Localization for KIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIN Gene

Nucleus. Cytoplasm. Note=During S phase, strongly associated with the nuclear matrix, and to chromosomal DNA in the presence of DNA damage. Also shows cytoplasmic localization in elongated spermatids. {ECO:0000250 UniProtKB:Q8K339, ECO:0000269 PubMed:11880372, ECO:0000269 PubMed:12359749, ECO:0000269 PubMed:12754299, ECO:0000269 PubMed:12853634, ECO:0000269 PubMed:15831485}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIN gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for KIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,TAS --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0016363 nuclear matrix IDA 12754299
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with KIN: view

Pathways & Interactions for KIN Gene

genes like me logo Genes that share pathways with KIN: view

Pathways by source for KIN Gene

Gene Ontology (GO) - Biological Process for KIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IEA,IDA 12359749
GO:0006281 DNA repair IEA --
GO:0006310 DNA recombination IEA --
GO:0006397 mRNA processing TAS 17045609
GO:0006479 protein methylation TAS --
genes like me logo Genes that share ontologies with KIN: view

No data available for SIGNOR curated interactions for KIN Gene

Drugs & Compounds for KIN Gene

(2) Drugs for KIN Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with KIN: view

Transcripts for KIN Gene

Unigene Clusters for KIN Gene

KIN, antigenic determinant of recA protein homolog (mouse):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIN Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c
SP1: -
SP2: - -
SP3: - -
SP4: -
SP5:
SP6:

Relevant External Links for KIN Gene

GeneLoc Exon Structure for
KIN
ECgene alternative splicing isoforms for
KIN

Expression for KIN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KIN Gene

This gene is overexpressed in Peripheral blood mononuclear cells (46.8) and Monocytes (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KIN Gene



Protein tissue co-expression partners for KIN Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KIN Gene:

KIN

SOURCE GeneReport for Unigene cluster for KIN Gene:

Hs.397918

mRNA Expression by UniProt/SwissProt for KIN Gene:

O60870-KIN17_HUMAN
Tissue specificity: Ubiquitously expressed in all tissues examined, with highest levels in skeletal muscle, heart and testis. Differentially expressed in non-tumorigenic and tumorigenic cell lines. Highly expressed in proliferating epithelial keratinocyte cells in vitro (at protein level).

Evidence on tissue expression from TISSUES for KIN Gene

  • Muscle(2.2)
genes like me logo Genes that share expression patterns with KIN: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIN Gene

Orthologs for KIN Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KIN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIN 33 34
  • 99.83 (n)
oppossum
(Monodelphis domestica)
Mammalia KIN 34
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIN 33 34
  • 90.9 (n)
cow
(Bos Taurus)
Mammalia KIN 33 34
  • 90 (n)
rat
(Rattus norvegicus)
Mammalia Kin 33
  • 85.88 (n)
mouse
(Mus musculus)
Mammalia Kin 33 16 34
  • 85.85 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KIN 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIN 33 34
  • 81.41 (n)
lizard
(Anolis carolinensis)
Reptilia KIN 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kin 33
  • 76.61 (n)
Str.472 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6806 33
zebrafish
(Danio rerio)
Actinopterygii kin 33 34
  • 70.14 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010352 33
  • 57.94 (n)
fruit fly
(Drosophila melanogaster)
Insecta kin17 35 33 34
  • 55.67 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y52B11A.9 33
  • 50.47 (n)
Y52B11A.9 35 34
  • 45 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RTS2 34 36
  • 32 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G55460 33
  • 54.21 (n)
rice
(Oryza sativa)
Liliopsida Os03g0570300 33
  • 61.11 (n)
Os.20977 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 59 (a)
OneToOne
Species where no ortholog for KIN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIN Gene

ENSEMBL:
Gene Tree for KIN (if available)
TreeFam:
Gene Tree for KIN (if available)

Paralogs for KIN Gene

No data available for Paralogs for KIN Gene

Variants for KIN Gene

Sequence variations from dbSNP and Humsavar for KIN Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000056538 -- 7,766,900(-) T/C intron_variant
rs1000077012 -- 7,781,279(-) A/C intron_variant
rs1000099604 -- 7,785,227(-) G/A intron_variant
rs1000103661 -- 7,767,171(-) T/C intron_variant
rs1000154991 -- 7,779,728(-) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KIN Gene

Variant ID Type Subtype PubMed ID
dgv31e215 CNV deletion 23714750
dgv357n106 CNV deletion 24896259
esv2074151 CNV deletion 18987734
esv2492826 CNV deletion 19546169
esv2619860 CNV deletion 19546169
esv2732384 CNV deletion 23290073
esv2732395 CNV deletion 23290073
esv2732406 CNV deletion 23290073
esv2732417 CNV deletion 23290073
esv5007 CNV loss 18987735
esv9005 CNV loss 19470904
nsv1072672 CNV deletion 25765185
nsv25062 CNV deletion 16902084
nsv549933 CNV gain 21841781
nsv958294 CNV deletion 24416366

Variation tolerance for KIN Gene

Residual Variation Intolerance Score: 36.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KIN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIN Gene

Disorders for KIN Gene

Additional Disease Information for KIN

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for KIN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIN Gene

Publications for KIN Gene

  1. The human stress-activated protein kin17 belongs to the multiprotein DNA replication complex and associates in vivo with mammalian replication origins. (PMID: 15831485) Miccoli L … Angulo JF (Molecular and cellular biology 2005) 3 4 22 58
  2. Global genome repair is required to activate KIN17, a UVC-responsive gene involved in DNA replication. (PMID: 12525703) Masson C … Angulo JF (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 22 58
  3. Participation of kin17 protein in replication factories and in other DNA transactions mediated by high molecular weight nuclear complexes. (PMID: 12754299) Biard DS … Angulo JF (Molecular cancer research : MCR 2003) 3 4 22 58
  4. Selective interactions of human kin17 and RPA proteins with chromatin and the nuclear matrix in a DNA damage- and cell cycle-regulated manner. (PMID: 12853634) Miccoli L … Angulo JF (Nucleic acids research 2003) 3 4 22 58
  5. Human kin17 protein directly interacts with the simian virus 40 large T antigen and inhibits DNA replication. (PMID: 12359749) Miccoli L … Angulo JF (Cancer research 2002) 3 4 22 58

Products for KIN Gene

Sources for KIN Gene

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