Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KIN Gene

protein-coding   GIFtS: 57
GCID: GC10M007795

KIN, Antigenic Determinant Of RecA Protein Homolog (Mouse)

(Previous name: antigenic determinant of recA protein (mouse) homolog)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
KIN, Antigenic Determinant Of RecA Protein Homolog (Mouse)1 2     Antigenic Determinant Of RecA Protein (Mouse) Homolog1
BTCD2 3 5     DNA/RNA-Binding Protein KIN172
KIN172 3 5     KIN, Antigenic Determinant Of RecA Protein Homolog3
Binding To Curved DNA2 3     

External Ids:    HGNC: 63271   Entrez Gene: 229442   Ensembl: ENSG000001516577   OMIM: 6017205   UniProtKB: O608703   

Export aliases for KIN gene to outside databases

Previous GC identifers: GC10M007741 GC10M007945 GC10M007801 GC10M007837 GC10M007715


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KIN Gene:
The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is
redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization
of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on
protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of
the bacterial RecA protein, a characteristic shared by this human ortholog. Alternative splicing of this gene
results in multiple transcript variants. (provided by RefSeq, Jan 2012)

GeneCards Summary for KIN Gene: 
KIN (KIN, antigenic determinant of recA protein homolog (mouse)) is a protein-coding gene. Diseases associated with KIN include actinic keratosis, and cheilitis. GO annotations related to this gene include double-stranded DNA binding and RNA binding.

UniProtKB/Swiss-Prot: KIN17_HUMAN, O60870
Function: Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication
factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May
play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing.
Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By
similarity). Binds via its C-terminal domain to RNA in vitro

Gene Wiki entry for KIN Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_008705.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KIN gene promoter:
         TBP   PPAR-gamma1   Elk-1   AML1a   Pbx1a   ATF-2   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKIN promoter sequence
   Search SABiosciences Chromatin IP Primers for KIN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p15-p14   Ensembl cytogenetic band:  10p14   HGNC cytogenetic band: 10p15-p14

KIN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIN gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M007795:  view genomic region     (about GC identifiers)

Start:
7,795,188 bp from pter      End:
7,829,990 bp from pter
Size:
34,803 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KIN17_HUMAN, O60870 (See protein sequence)
Recommended Name: DNA/RNA-binding protein KIN17  
Size: 393 amino acids; 45374 Da
Subunit: Interacts with SV40 large T antigen. Associated with DNA polymerase alpha, RFC1 and cyclin A, in
multiprotein DNA replication complexes. Also associates with replication origins at the G1/S phase boundary and
throughout the S phase in vivo
Subcellular location: Nucleus. Cytoplasm. Note=During S phase, strongly associated with the nuclear matrix, and to
chromosomal DNA in the presence of DNA damage. Also shows cytoplasmic localization in elongated spermatids
Miscellaneous: Recognized by antibodies directed against the RecA protein (By similarity)
2 PDB 3D structures from and Proteopedia for KIN:
2CKK (3D)        2V1N (3D)    

Explore the universe of human proteins at neXtProt for KIN: NX_O60870

Explore proteomics data for KIN at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O60870

  • KIN Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KIN Protein Expression
    REFSEQ proteins: NP_036443.1  
    ENSEMBL proteins: 
     ENSP00000473950   ENSP00000368881   ENSP00000440529   ENSP00000440390  

    Human Recombinant Protein Products for KIN: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for KIN
    OriGene Protein Over-expression Lysate for KIN
    OriGene MassSpec for KIN 
    OriGene Custom Protein Services for KIN
    GenScript Custom Purified and Recombinant Proteins Services for KIN
    Novus Biologicals KIN Proteins
    Novus Biologicals KIN Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for KIN
    Cloud-Clone Corp. Proteins for KIN 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS1923796
    GO:0005737cytoplasm IEA--
    GO:0016363nuclear matrix IDA12754299

    KIN for ontologies           About GeneDecksing



    KIN Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for KIN
    GenScript Custom Superior Antibodies Services for KIN
    Abcam antibodies for KIN
    Cloud-Clone Corp. Antibodies for KIN 
    ThermoFisher Antibodies for KIN
    LSBio Antibodies in human, mouse, rat for KIN 

    Assay Products for KIN: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KIN
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KIN
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for KIN 
    Cloud-Clone Corp. CLIAs for KIN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR019447 DNA/RNA-bd_Kin17_cons_domain

    Graphical View of Domain Structure for InterPro Entry O60870

    ProtoNet protein and cluster: O60870

    1 Blocks protein domain: IPB006646 KOW (Kyprides

    UniProtKB/Swiss-Prot: KIN17_HUMAN, O60870
    Domain: The C-terminal domain (268-393) is organized into 2 subdomains that bear structural similarities to
    SH3-like domains. Both subdomains adopt a similar 5-stranded beta-barrel-like fold and are connected to each
    other by a short linker of 5 residues. The 5 beta-sheets are packed at approximately right angles against each
    other. A highly conserved groove formed at the interface between the 2 subdomains, comprised of Lys residues 302
    and 391 and other positively charged residues, may possibly be the site of RNA-binding
    Similarity: Belongs to the KIN17 family
    Similarity: Contains 1 C2H2-type zinc finger


    KIN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KIN17_HUMAN, O60870
    Function: Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication
    factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May
    play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing.
    Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By
    similarity). Binds via its C-terminal domain to RNA in vitro
    Induction: By UVC irradiation in quiescent primary fibroblasts. By mitomycin C in human melanoma MeWO cells

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS1923796
    GO:0003690double-stranded DNA binding ISS--
    GO:0003723RNA binding IDA17045609
    GO:0046872metal ion binding IEA--
         
    KIN for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for KIN 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KIN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KIN 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KIN 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KIN
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate KIN (see all 15):
    hsa-miR-21* hsa-miR-495 hsa-miR-607 hsa-miR-520d-5p hsa-miR-300 hsa-miR-7-2* hsa-miR-381 hsa-miR-4282
    SwitchGear 3'UTR luciferase reporter plasmidKIN 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KIN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIN

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KIN
    Sirion Biotech Customized adenovirus for overexpression of KIN

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for KIN (see all 7)
    OriGene ORF clones in mouse, rat for KIN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KIN (NM_012311)
    Sino Biological Human cDNA Clone for KIN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KIN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIN
    Sirion Biotech Customized lentivirus for stable overexpression of KIN 
                         Customized lentivirus expression plasmids for stable overexpression of KIN 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KIN
    Search LifeMap BioReagents cell lines for KIN
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIN


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIN

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/8 Interacting proteins for KIN (O608702, 3 ENSP000003688814) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPA2P159273, ENSP000003630214I2D: score=1 STRING: ENSP00000363021
    RPA1P276943, ENSP000002547194I2D: score=1 STRING: ENSP00000254719
    BUD13Q9BRD03I2D: score=5 
    PABPC4Q133103I2D: score=5 
    RBL1P287493I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication IDA12359749
    GO:0006281DNA repair IEA--
    GO:0006310DNA recombination IEA--
    GO:0006397mRNA processing TAS17045609
    GO:0006974response to DNA damage stimulus IEP12853634

    KIN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KIN for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KIN (KIN17)

    2 Novoseek inferred chemical compound relationships for KIN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mimosine 77.3 1 12853634 (1)
    zinc 27.9 2 1923796 (1), 9466698 (1)

    Search CenterWatch for drugs/clinical trials and news about KIN / KIN17

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KIN gene: 
    NM_012311.3  

    Unigene Cluster for KIN:

    KIN, antigenic determinant of recA protein homolog (mouse)
    Hs.397918  [show with all ESTs]
    Unigene Representative Sequence: NM_012311
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000498098 ENST00000379562(uc001ijt.3) ENST00000463666 ENST00000471320
    ENST00000460089 ENST00000535925(uc010qaz.2) ENST00000543003(uc010qba.2)


    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KIN
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate KIN (see all 15):
    hsa-miR-21* hsa-miR-495 hsa-miR-607 hsa-miR-520d-5p hsa-miR-300 hsa-miR-7-2* hsa-miR-381 hsa-miR-4282
    SwitchGear 3'UTR luciferase reporter plasmidKIN 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KIN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIN
    Clone
    Products:
         
    OriGene clones in human, mouse for KIN (see all 7)
    OriGene ORF clones in mouse, rat for KIN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KIN (NM_012311)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KIN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIN
    Sirion Biotech Customized lentivirus for stable overexpression of KIN 
                         Customized lentivirus expression plasmids for stable overexpression of KIN 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for KIN
    OriGene qSTAR qPCR primer pairs in human, mouse for KIN
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KIN
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIN

    Additional mRNA sequence: 

    AJ005273.1 AK296637.1 AK309059.1 BC017309.2 BC037913.2 NR_045609.1 

    10 DOTS entries:

    DT.206218  DT.91996611  DT.40287372  DT.436428  DT.100751134  DT.100751136  DT.40125534  DT.92420255 
    DT.92440073  DT.95149006 

    24/101 AceView cDNA sequences (see all 101):

    BQ221694 R92811 BM453332 BM689918 CR595908 BU161074 BM759166 BQ130494 
    CB158644 BG943319 CD109094 BM782457 CR618602 BM711163 NM_012311 CB269659 
    AA827733 BI862461 BE896845 AW183486 AA355283 CK003350 BG676860 AA770446 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for KIN (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c
    SP1:                          -                                                                                                         
    SP2:                    -     -                                                                                                         
    SP3:                                                                          -     -                                                   
    SP4:                                                                                            -                                       
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for KIN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KIN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGTATCAAA
    KIN Expression
    About this image


    See KIN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KIN

    SOURCE GeneReport for Unigene cluster: Hs.397918

    UniProtKB/Swiss-Prot: KIN17_HUMAN, O60870
    Tissue specificity: Ubiquitously expressed in all tissues examined, with highest levels in skeletal muscle, heart
    and testis. Differentially expressed in non-tumorigenic and tumorigenic cell lines. Highly expressed in
    proliferating epithelial keratinocyte cells in vitro (at protein level)

        SABiosciences Custom PCR Arrays for KIN
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for KIN
    OriGene qSTAR qPCR primer pairs in human, mouse for KIN
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KIN
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIN
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for KIN gene from 10/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kin1 , 5 antigenic determinant of rec-A protein1, 5 86.36(n)1
    92.84(a)1
      2 (6.88 cM)5
    165881  NM_025280.21  NP_079556.11 
     100805935 
    chicken
    (Gallus gallus)
    Aves KIN1 KIN, antigenic determinant of recA protein homolog more 81.54(n)
    88.97(a)
      419109  XM_417297.3  XP_417297.3 
    lizard
    (Anolis carolinensis)
    Reptilia KIN6
    Uncharacterized protein
    83(a)
    1 ↔ 1
    5(192408-205436)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.68062 Xenopus laevis transcribed sequence with moderate similarity more 78.68(n)    BX846650.1 
    zebrafish
    (Danio rerio)
    Actinopterygii kin1 KIN, antigenic determinant of recA protein homolog more 70.49(n)
    77.34(a)
      555316  NM_001030086.2  NP_001025257.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta kin171 , 3 DNA binding3
    CG5649-PA1
    58(a)3
    54.97(n)1
    53.4(a)1
      77B53
    402421  NM_140955.31  NP_649212.21 
    worm
    (Caenorhabditis elegans)
    Secernentea Y52B11A.93
    CELE_Y52B11A.91
    Protein Y52B11A.91 45(a)3
    52.1(n)1
    49.61(a)1
      I(11042149-11046876)3
    1730051  NM_060459.21  NP_492860.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RTS2(YOR077W)4
    RTS21
    Basic zinc-finger protein, similar to human and mouse more4
    Rts2p1
    46.63(n)1
    36.52(a)1
      15(471899-472597)4
    8542441, 4  NP_014720.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G554601 DNA/RNA-binding protein Kin17 conserved region-containing more 54.1(n)
    51.54(a)
      841993  NM_104422.1  NP_564690.1 
    rice
    (Oryza sativa)
    Liliopsida Os.209772 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 77.14(n)    AK069396.1 


    ENSEMBL Gene Tree for KIN (if available)
    TreeFam Gene Tree for KIN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/840 SNPs in KIN are shown (see all 840)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs349696041,2
    C--7734818(+) AAAAA-/AATGCCT 1 -- int11Minor allele frequency- AA:0.00NA 2
    rs1856431641,2
    --7792457(+) CCTTTC/GACTAT 2 -- ds50010--------
    rs736284651,2
    C,F--7792468(+) TAGACG/AAGGCC 2 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1826192771,2
    --7792482(+) CCACAC/TAAGGG 2 -- ds50010--------
    rs736284661,2
    C,F--7792525(+) GAGATG/AGGGTC 2 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1120662491,2
    C,F--7792595(+) CTCCCG/AGGTTC 2 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1921541041,2
    --7792652(+) GTGAGC/TCACCA 2 -- ds50010--------
    rs1175258211,2
    C,F--7792749(+) TACACA/GTTGTT 2 -- ds50011Minor allele frequency- G:0.03NA 120
    rs1421333201,2
    C--7792751(+) CACATG/TGTTAA 2 -- ds50010--------
    rs1835248451,2
    --7792757(+) GTTAAC/TGTTGC 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for KIN (7795188 - 7829990 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for KIN:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2732417CNV Deletion23290073

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KIN
    DNA2.0 Custom Variant and Variant Library Synthesis for KIN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601720    OMIM disorders: --

    6 diseases for KIN:    About MalaCards
    actinic keratosis    cheilitis    keratosis    melanoma
    alzheimer's disease    breast cancer


    KIN for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for KIN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 13.5 2 12751957 (1), 11604067 (1)
    tumors 0 2 12751957 (1), 11604067 (1)

    Genetic Association Database (GAD): KIN
    Human Genome Epidemiology (HuGE) Navigator: KIN (22 documents)

    Export disorders for KIN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KIN gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with KIN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Selective interactions of human kin17 and RPA proteins with chromatin and the nuclear matrix in a DNA damage- and cell cycle-regulated manner. (PubMed id 12853634)1, 2, 9 Miccoli L.... Angulo J.F. (2003)
    2. The human stress-activated protein kin17 belongs to the multiprotein DNA replication complex and associates in vivo with mammalian replication origins. (PubMed id 15831485)1, 2, 9 Miccoli L.... Angulo J.F. (2005)
    3. Identification and expression of the cDNA of KIN17, a zinc-finger gene located on mouse chromosome 2, encoding a new DNA-binding protein. (PubMed id 1923796)1, 3, 9 Angulo J.F....Devoret R. (1991)
    4. Human kin17 protein directly interacts with the simian virus 40 large T antigen and inhibits DNA replication. (PubMed id 12359749)1, 2, 9 Miccoli L.... Angulo J.F. (2002)
    5. Global genome repair is required to activate KIN17, a UVC-responsive gene involved in DNA replication. (PubMed id 12525703)1, 2, 9 Masson C.... Angulo J.F. (2003)
    6. Molecular cloning and characterization of the human KIN17 cDNA encoding a component of the UVC response that is conserved among metazoans. (PubMed id 10964102)1, 2, 9 Kannouche P.... Angulo J.F. (2000)
    7. Differential expression of the HsKin17 protein during differentiation of in vitro reconstructed human skin. (PubMed id 9266022)1, 2, 9 Biard D.S.F.... Angulo J.F. (1997)
    8. Participation of kin17 protein in replication factories and in other DNA transactions mediated by high molecular weight nuclear complexes. (PubMed id 12754299)1, 2, 9 Biard D.S.F.... Angulo J.F. (2003)
    9. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1, 2 Cloutier P.... Coulombe B. (2013)
    10. A tandem of SH3-like domains participates in RNA binding in KIN17, a human protein activated in response to genotoxics. (PubMed id 17045609)1, 2 le Maire A.... Zinn-Justin S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22944 HGNC: 6327 AceView: KIN Ensembl:ENSG00000151657 euGenes: HUgn22944
    ECgene: KIN H-InvDB: KIN

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KIN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KIN gene:
    Search GeneIP for patents involving KIN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for KIN  
     OriGene qPCR primer pairs and template standards for KIN   OriGene Protein Over-expression Lysate for KIN  
     OriGene MassSpec something-or-other for KIN   OriGene clones in human, mouse for KIN  
     OriGene qSTAR qPCR primer pairs in human, mouse for KIN   OriGene Purified Protein for KIN  
     OriGene ORF clones in mouse, rat for KIN   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KIN   OriGene Custom Protein Services for KIN  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KIN
     QIAGEN SeqTarget long-range PCR primers for resequencing KIN
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIN
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIN
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIN
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIN
     GenScript Custom Purified and Recombinant Proteins Services for KIN GenScript cDNA clones with any tag delivered in your preferred vector for KIN
     GenScript Custom Assay Services for KIN GenScript Custom Superior Antibodies Services for KIN
     GenScript Custom overexpressing Cell Line Services for KIN CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in KIN promoter
     Search Chromatin IP Primers for KIN
     RT2 qPCR Primer Assay in human, mouse, rat KIN
     Search GNC Networks for KIN
     SABiosciences Custom PCR Arrays for KIN
     Search Tocris compounds for KIN (KIN17)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for KIN
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     KIN proteins
     KIN lysates
     Antibodies for KIN
     See all of Abcam's Antibodies, Kits and Proteins for KIN
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for KIN




     Proteins for KIN
     Antibodies for KIN
     ELISAs for KIN
     CLIAs for KIN
     Search LifeMap BioReagents cell lines for KIN
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIN
     SwitchGear 3'UTR luciferase reporter plasmids for KIN
     SwitchGear Promoter luciferase reporter plasmids for KIN
     ThermoFisher Antibodies for KIN
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIN
     inGenious Targeting Laboratory - Custom generated mouse model solutions for KIN
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KIN
    Customized:
     lentivirus for stable overexpression of KIN
     lentivirus expression plasmids for stable overexpression of KIN
     adenovirus for overexpression of KIN
     LSBio Antibodies in human, mouse, rat for KIN
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KIN gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4