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Aliases for KIFC3 Gene

Aliases for KIFC3 Gene

  • Kinesin Family Member C3 2 3 5

External Ids for KIFC3 Gene

Previous GeneCards Identifiers for KIFC3 Gene

  • GC16M048187
  • GC16M057877
  • GC16M057526
  • GC16M057567
  • GC16M056349
  • GC16M057792
  • GC16M043659

Summaries for KIFC3 Gene

Entrez Gene Summary for KIFC3 Gene

  • This gene encodes a member of the kinesin-14 family of microtubule motors. Members of this family play a role in the formation, maintenance and remodeling of the bipolar mitotic spindle. The protein encoded by this gene has cytoplasmic functions in the interphase cells. It may also be involved in the final stages of cytokinesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

GeneCards Summary for KIFC3 Gene

KIFC3 (Kinesin Family Member C3) is a Protein Coding gene. Diseases associated with KIFC3 include Bardet-Biedl Syndrome. Among its related pathways are Chaperonin-mediated protein folding and Stabilization and expansion of the E-cadherin adherens junction. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIFC1.

UniProtKB/Swiss-Prot for KIFC3 Gene

  • Minus-end microtubule-dependent motor protein. Involved in apically targeted transport (By similarity). Required for zonula adherens maintenance.

Gene Wiki entry for KIFC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIFC3 Gene

Genomics for KIFC3 Gene

Regulatory Elements for KIFC3 Gene

Enhancers for KIFC3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KIFC3 on UCSC Golden Path with GeneCards custom track

Promoters for KIFC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KIFC3 on UCSC Golden Path with GeneCards custom track

Genomic Location for KIFC3 Gene

Chromosome:
16
Start:
57,758,217 bp from pter
End:
57,863,053 bp from pter
Size:
104,837 bases
Orientation:
Minus strand

Genomic View for KIFC3 Gene

Genes around KIFC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIFC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIFC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIFC3 Gene

Proteins for KIFC3 Gene

  • Protein details for KIFC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVG8-KIFC3_HUMAN
    Recommended name:
    Kinesin-like protein KIFC3
    Protein Accession:
    Q9BVG8
    Secondary Accessions:
    • A8K6S2
    • B7Z484
    • O75299
    • Q49A29
    • Q49AQ0
    • Q59G19
    • Q8IUT3
    • Q96HW6

    Protein attributes for KIFC3 Gene

    Size:
    833 amino acids
    Molecular mass:
    92775 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH34234.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAH41132.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAH47051.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BAD92527.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KIFC3 Gene

    Alternative splice isoforms for KIFC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIFC3 Gene

Proteomics data for KIFC3 Gene at MOPED

Post-translational modifications for KIFC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KIFC3 Gene

Domains & Families for KIFC3 Gene

Gene Families for KIFC3 Gene

Protein Domains for KIFC3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BVG8

UniProtKB/Swiss-Prot:

KIFC3_HUMAN :
  • Contains 1 kinesin motor domain.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Domain:
  • Contains 1 kinesin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIFC3: view

Function for KIFC3 Gene

Molecular function for KIFC3 Gene

GENATLAS Biochemistry:
kinesin,heavy chain member C3,microtubule associated protein,ATP dependent superfamily,highly expressed in the retina and retinal pigment epithelium,homolog to morone saxatilus FKIF2
UniProtKB/Swiss-Prot Function:
Minus-end microtubule-dependent motor protein. Involved in apically targeted transport (By similarity). Required for zonula adherens maintenance.

Gene Ontology (GO) - Molecular Function for KIFC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20360068
GO:0016887 ATPase activity IBA --
genes like me logo Genes that share ontologies with KIFC3: view
genes like me logo Genes that share phenotypes with KIFC3: view

Animal Models for KIFC3 Gene

MGI Knock Outs for KIFC3:

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KIFC3 Gene

Localization for KIFC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIFC3 Gene

Cell junction, adherens junction. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic vesicle membrane; Peripheral membrane protein. Note=Apical cell membrane. On membrane organelles immediately beneath the apical plasma membrane of renal tubular epithelial cells. Localized in the distal tubules and loops of Henle in the kidney, but not in the proximal tubules or the glomeruli, with stronger staining in the apical area of these epithelial cells (By similarity). Localizes along zonula adherens only at mature cell-cell contacts. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIFC3 Gene COMPARTMENTS Subcellular localization image for KIFC3 gene
Compartment Confidence
cytoskeleton 5
extracellular 5
cytosol 3
golgi apparatus 3
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for KIFC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IDA 19041755
GO:0030659 cytoplasmic vesicle membrane IEA --
genes like me logo Genes that share ontologies with KIFC3: view

Pathways & Interactions for KIFC3 Gene

genes like me logo Genes that share pathways with KIFC3: view

Gene Ontology (GO) - Biological Process for KIFC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007017 microtubule-based process IEA --
genes like me logo Genes that share ontologies with KIFC3: view

No data available for SIGNOR curated interactions for KIFC3 Gene

Drugs & Compounds for KIFC3 Gene

No Compound Related Data Available

Transcripts for KIFC3 Gene

Unigene Clusters for KIFC3 Gene

Kinesin family member C3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIFC3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b · 19c ^
SP1: - - -
SP2: - - - -
SP3: - - - - - - - - - - -
SP4:
SP5: - - - - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - - - -
SP8: - - - - - - - - - - -
SP9: - - - - - - - - - - - -
SP10: -
SP11:
SP12: - - - - - - - - - - - - - -
SP13: - - - - - - - - - - -
SP14: - - - - - - - - - - -
SP15: - - - - -
SP16:
SP17:
SP18:
SP19:

ExUns: 20a · 20b · 20c · 20d ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b ^ 28a · 28b · 28c ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34a · 34b
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13:
SP14:
SP15:
SP16: - -
SP17: -
SP18:
SP19:

Relevant External Links for KIFC3 Gene

GeneLoc Exon Structure for
KIFC3
ECgene alternative splicing isoforms for
KIFC3

Expression for KIFC3 Gene

mRNA expression in normal human tissues for KIFC3 Gene

Protein differential expression in normal tissues from HIPED for KIFC3 Gene

This gene is overexpressed in Monocytes (23.5), Peripheral blood mononuclear cells (13.1), Testis (13.0), and Adipocyte (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIFC3 Gene



SOURCE GeneReport for Unigene cluster for KIFC3 Gene Hs.23131

genes like me logo Genes that share expression patterns with KIFC3: view

Protein tissue co-expression partners for KIFC3 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KIFC3 Gene

Orthologs for KIFC3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KIFC3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KIFC3 35
  • 91.31 (n)
  • 96.98 (a)
KIFC3 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIFC3 35
  • 91.36 (n)
  • 96.84 (a)
KIFC3 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kifc3 35
  • 87.5 (n)
  • 92.84 (a)
Kifc3 16
Kifc3 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KIFC3 35
  • 97.42 (n)
  • 97.42 (a)
KIFC3 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kifc3 35
  • 88.78 (n)
  • 95.15 (a)
oppossum
(Monodelphis domestica)
Mammalia KIFC3 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIFC3 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIFC3 35
  • 81.22 (n)
  • 81.47 (a)
KIFC3 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIFC3 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kifc3 35
  • 60.22 (n)
  • 58.13 (a)
zebrafish
(Danio rerio)
Actinopterygii kifc3 35
  • 66.34 (n)
  • 62.91 (a)
wufc51b05 35
kifc3 36
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ncd 37
  • 34 (a)
ncd 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea klp-3 37
  • 45 (a)
klp-16 36
  • 26 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KAR3 36
  • 25 (a)
OneToMany
barley
(Hordeum vulgare)
Liliopsida Hv.2916 35
rice
(Oryza sativa)
Liliopsida Os.24220 35
wheat
(Triticum aestivum)
Liliopsida Ta.8288 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10026 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 57 (a)
OneToMany
Species with no ortholog for KIFC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for KIFC3 Gene

ENSEMBL:
Gene Tree for KIFC3 (if available)
TreeFam:
Gene Tree for KIFC3 (if available)

Paralogs for KIFC3 Gene

Paralogs for KIFC3 Gene

genes like me logo Genes that share paralogs with KIFC3: view

Variants for KIFC3 Gene

Sequence variations from dbSNP and Humsavar for KIFC3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs17854089 - 57,769,641(+) GGAAG(A/C)CGCGC reference, missense
rs3937502 -- 57,799,141(-) CTGAC(G/T)GAAGC intron-variant, upstream-variant-2KB
rs165997 -- 57,841,592(-) cctcc(C/T)ggctt intron-variant
rs173511 -- 57,842,066(+) tgatg(C/T)gcacc intron-variant
rs173512 -- 57,850,034(+) ggctg(C/T)agtga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIFC3 Gene

Variant ID Type Subtype PubMed ID
nsv906729 CNV Loss 21882294
nsv525464 CNV Gain 19592680
nsv528250 CNV Loss 19592680
nsv509622 CNV Insertion 20534489
dgv2872n71 CNV Loss 21882294
nsv471089 CNV Loss 18288195
dgv2873n71 CNV Loss 21882294
dgv2874n71 CNV Loss 21882294
nsv817732 CNV Loss 17921354
nsv523237 CNV Loss 19592680
nsv526855 CNV Loss 19592680

Variation tolerance for KIFC3 Gene

Residual Variation Intolerance Score: 4.22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.74; 46.75% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KIFC3 Gene

Disorders for KIFC3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KIFC3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
bardet-biedl syndrome
  • laurence-moon syndrome
- elite association - COSMIC cancer census association via MalaCards
Search KIFC3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KIFC3

Genetic Association Database (GAD)
KIFC3
Human Genome Epidemiology (HuGE) Navigator
KIFC3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIFC3
genes like me logo Genes that share disorders with KIFC3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIFC3 Gene

Publications for KIFC3 Gene

  1. Cloning of a novel C-terminal kinesin (KIFC3) that maps to human chromosome 16q13-q21 and thus is a candidate gene for Bardet-Biedl syndrome. (PMID: 9782090) Hoang E.H. … Burnside B. (Genomics 1998) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy. (PMID: 26460568) Johnson-Kerner B.L. … Wichterle H. (PLoS ONE 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. KIFC3 promotes mitotic progression and integrity of the central spindle in cytokinesis. (PMID: 24275865) Nachbar J. … MA1sch A. (Cell Cycle 2014) 3

Products for KIFC3 Gene

Sources for KIFC3 Gene

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