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KIFC3 Gene

protein-coding   GIFtS: 63
GCID: GC16M057792

Kinesin Family Member C3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kinesin Family Member C31 2
Kinesin-Like Protein KIFC32

External Ids:    HGNC: 63261   Entrez Gene: 38012   Ensembl: ENSG000001408597   OMIM: 6045355   UniProtKB: Q9BVG83   

Export aliases for KIFC3 gene to outside databases

Previous GC identifers: GC16M048187 GC16M057877 GC16M057526 GC16M057567 GC16M056349 GC16M043659


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KIFC3 Gene:
KIFC3 belongs to the large superfamily of kinesins, molecular motors that use the energy of ATP hydrolysis to
translocate cargoes along microtubules. Members share extensive homology within a globular domain containing the
microtubule- and ATP-binding sites and have a coiled-coil stalk domain that mediates oligomerization. Different
kinesin family members participate in specific and diverse motile processes, such as cell division, organelle
transport, and nuclear movement (Hoang et al., 1998 (PubMed 9782090)).(supplied by OMIM, Mar 2009)

GeneCards Summary for KIFC3 Gene:
KIFC3 (kinesin family member C3) is a protein-coding gene. Diseases associated with KIFC3 include bardet-biedl syndrome, and primary biliary cirrhosis. GO annotations related to this gene include microtubule binding and microtubule motor activity. An important paralog of this gene is KIFC2.

UniProtKB/Swiss-Prot: KIFC3_HUMAN, Q9BVG8
Function: Minus-end microtubule-dependent motor protein. Involved in apically targeted transport (By similarity).
Required for zonula adherens maintenance

Gene Wiki entry for KIFC3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KIFC3 gene promoter:
         p53   c-Myb   CUTL1   LCR-F1   NF-AT   Arnt   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for KIFC3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KIFC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13-q21   Ensembl cytogenetic band:  16q21   HGNC cytogenetic band: 16q13-q21

KIFC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIFC3 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M057792:  view genomic region     (about GC identifiers)

Start:
57,792,129 bp from pter      End:
57,896,957 bp from pter
Size:
104,829 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: KIFC3_HUMAN, Q9BVG8 (See protein sequence)
Recommended Name: Kinesin-like protein KIFC3  
Size: 833 amino acids; 92775 Da
Sequence caution: Sequence=AAH34234.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=AAH41132.1;
Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=AAH47051.1; Type=Miscellaneous discrepancy;
Note=Intron retention; Sequence=BAD92527.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for KIFC3:
2H58 (3D)    
Secondary accessions: A8K6S2 O75299 Q49A29 Q49AQ0 Q59G19 Q8IUT3 Q96HW6
Alternative splicing: 4 isoforms:  Q9BVG8-3   Q9BVG8-2   Q9BVG8-4   Q9BVG8-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KIFC3: NX_Q9BVG8

Explore proteomics data for KIFC3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KIFC3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001123571.1  NP_001123572.1  NP_005541.3  

    ENSEMBL proteins: 
     ENSP00000454659   ENSP00000368976   ENSP00000401696   ENSP00000457568   ENSP00000396399  
     ENSP00000442008   ENSP00000438805   ENSP00000444012   ENSP00000456239   ENSP00000458009  
     ENSP00000457232   ENSP00000457326   ENSP00000454493   ENSP00000457948   ENSP00000454501  
     ENSP00000457247   ENSP00000454403   ENSP00000456780   ENSP00000454615   ENSP00000454632  
     ENSP00000456402   ENSP00000455276   ENSP00000457144   ENSP00000456354   ENSP00000455067  
     ENSP00000444884  
    Reactome Protein details: Q9BVG8

    KIFC3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for KIFC3

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    Cloud-Clone Corp. CLIAs for KIFC3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KIF: Kinesins

    4 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR001752 Kinesin_motor_dom
     IPR019821 Kinesin_motor_CS
     IPR027640 Kinesin-like_fam

    Graphical View of Domain Structure for InterPro Entry Q9BVG8

    ProtoNet protein and cluster: Q9BVG8

    1 Blocks protein domain: IPB001752 Kinesin

    UniProtKB/Swiss-Prot: KIFC3_HUMAN, Q9BVG8
    Similarity: Belongs to the kinesin-like protein family
    Similarity: Contains 1 kinesin-motor domain


    KIFC3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KIFC3_HUMAN, Q9BVG8
    Function: Minus-end microtubule-dependent motor protein. Involved in apically targeted transport (By similarity).
    Required for zonula adherens maintenance

         Genatlas biochemistry entry for KIFC3:
    kinesin,heavy chain member C3,microtubule associated protein,ATP dependent superfamily,highly expressed in the
    retina and retinal pigment epithelium,homolog to morone saxatilus FKIF2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003777microtubule motor activity IEA--
    GO:0005524ATP binding IEA--
    GO:0008017microtubule binding IEA--
         
    KIFC3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KIFC3:
     Decreased nuclei size in G2M 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Kifc3):
     hematopoietic system  renal/urinary system  vision/eye 

    KIFC3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KIFC3
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    miRNA
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    miRTarBase miRNAs that target KIFC3:
    hsa-mir-26b-5p (MIRT028959)

    Block miRNA regulation of human, mouse, rat KIFC3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KIFC3 (see all 11):
    hsa-miR-3194-5p hsa-miR-1237 hsa-miR-1184 hsa-miR-214 hsa-miR-2115 hsa-miR-2116 hsa-miR-4323 hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidKIFC3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KIFC3

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIFC3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KIFC3_HUMAN, Q9BVG8: Cell junction, adherens junction. Cytoplasm, cytoskeleton, microtubule organizing center,
    centrosome. Cytoplasmic vesicle membrane; Peripheral membrane protein (By similarity). Note=Apical cell membrane.
    On membrane organelles immediately beneath the apical plasma membrane of renal tubular epithelial cells.
    Localized in the distal tubules and loops of Henle in the kidney, but not in the proximal tubules or the
    glomeruli, with stronger staining in the apical area of these epithelial cells (By similarity). Localizes along
    zonula adherens only at mature cell-cell contacts
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    golgi apparatus2
    mitochondrion2
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus IEA--
    GO:0005813centrosome IDA19041755
    GO:0005871kinesin complex IEA--
    GO:0005874microtubule IEA--
    GO:0005915zonula adherens IDA19041755

    KIFC3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KIFC3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Protein folding
    Chaperonin-mediated protein folding0.91
    Association of TriC/CCT with target proteins during biosynthesis0.58
    Protein folding0.91
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    3Stabilization and expansion of the E-cadherin adherens junction
    Stabilization and expansion of the E-cadherin adherens junction

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for KIFC3
        Stabilization and expansion of the E-cadherin adherens junction

    1 Reactome Pathway for KIFC3
        Association of TriC/CCT with target proteins during biosynthesis



    KIFC3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KIFC3
    Interactions:

        Search GeneGlobe Interaction Network for KIFC3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KIFC3 (Q9BVG82, 3 ENSP000003689764) via UniProtKB, MINT, STRING, and/or I2D (see all 194)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMC1AQ146833, ENSP000003234214I2D: score=4 STRING: ENSP00000323421
    ANXA13P272163, ENSP000002622194I2D: score=1 STRING: ENSP00000262219
    CDC6Q997413, ENSP000002097284I2D: score=1 STRING: ENSP00000209728
    CDH1P128303, ENSP000002617694I2D: score=1 STRING: ENSP00000261769
    CDK3Q005263, ENSP000004000884I2D: score=1 STRING: ENSP00000400088
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007017microtubule-based process ----
    GO:0007018microtubule-based movement IEA--
    GO:0007030Golgi organization IEA--
    GO:0007601visual perception TAS9782090
    GO:0008152metabolic process TAS9782090

    KIFC3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KIFC3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KIFC3 gene (3 alternative transcripts): 
    NM_001130099.1  NM_001130100.1  NM_005550.3  

    Unigene Cluster for KIFC3:

    Kinesin family member C3
    Hs.23131  [show with all ESTs]
    Unigene Representative Sequence: NM_001130100
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 35):
    ENST00000465878(uc010vhw.2 uc002emo.4) ENST00000379655(uc002emp.3)
    ENST00000445690(uc002emq.3 uc010vhz.2) ENST00000565397 ENST00000421376(uc010cdf.3 uc010vhy.2)
    ENST00000541240(uc010cdg.1 uc002emr.1) ENST00000540079 ENST00000543930(uc010vhx.2)
    ENST00000562903(uc002emm.3) ENST00000564136(uc002emn.3) ENST00000565753
    ENST00000565270 ENST00000563266 ENST00000565481 ENST00000562503 ENST00000569222
    ENST00000562311 ENST00000569112
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    Selected qRT-PCR Assays for microRNAs that regulate KIFC3 (see all 11):
    hsa-miR-3194-5p hsa-miR-1237 hsa-miR-1184 hsa-miR-214 hsa-miR-2115 hsa-miR-2116 hsa-miR-4323 hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidKIFC3 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat KIFC3
      QuantiFast Probe-based Assays in human, mouse, rat KIFC3

    Additional mRNA sequence: 

    AB209290.1 AF004426.1 AK291737.1 AK295926.1 AK296995.1 AK299431.1 AK302743.1 AK303021.1 
    AK304132.1 AK307846.1 BC001211.1 BC008014.1 BC019057.2 BC034234.1 BC041132.1 BX647698.1 
    DQ426879.1 DQ426880.1 

    19 DOTS entries:

    DT.212978  DT.95249211  DT.100788225  DT.92430159  DT.97792795  DT.92415776  DT.92430160  DT.95249206 
    DT.100029138  DT.100842775  DT.100788226  DT.120687552  DT.95265581  DT.102842587  DT.120687532  DT.120687533 
    DT.91834406  DT.120687525  DT.91989700 

    Selected AceView cDNA sequences (see all 206):

    BC001211 AL041880 BM692152 AI017905 F06868 BC047051 BI966174 CR615160 
    BM666967 CD251860 BC019057 BE466082 F04426 AL041493 AI460356 BU527133 
    BI767570 AI417130 BQ022749 BX118043 BM980371 BM695889 BM556180 AU141433 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KIFC3 (see all 19)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b · 19c ^
    SP1:                                                                                                                    -     -     -                           
    SP2:                                                                                                              -     -     -     -                           
    SP3:                                                              -           -     -     -     -     -     -     -     -     -     -                           
    SP4:                                                                                                                                                            
    SP5:        -     -     -     -     -           -                 -     -     -     -     -     -     -     -     -     -     -     -                           

    ExUns: 20a · 20b · 20c · 20d ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b ^ 28a · 28b · 28c ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34a · 34b
    SP1:                                                        -           -                                   -                                             
    SP2:                                                        -           -                                                                 -               
    SP3:                                                        -           -                                   -                                             
    SP4:                                                        -           -                                   -                             -               
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for KIFC3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KIFC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KIFC3 Expression
    About this image

    KIFC3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KIFC3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.23131
        Custom PCR Arrays for KIFC3
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for KIFC3 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kifc31 , 5 kinesin family member C31, 5 87.5(n)1
    92.84(a)1
      8 (47.12 cM)5
    165821  NM_010631.21  NP_034761.31 
     950998325 
    chicken
    (Gallus gallus)
    Aves KIFC31 kinesin family member C3 81.22(n)
    81.47(a)
      415630  XM_413996.4  XP_413996.4 
    lizard
    (Anolis carolinensis)
    Reptilia KIFC36
    kinesin family member C3
    68(a)
    1 ↔ 1
    AAWZ02035082(193-41575)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia kifc31 kinesin family member C3 60.22(n)
    58.13(a)
      548839  NM_001197199.1  NP_001184128.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc51b052 wufc51b05 74.4(n)   325001  AI877745.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ncd3 centrosome separation
    minus-end-directed kinesin more
    34(a)   3 99C1   --
    worm
    (Caenorhabditis elegans)
    Secernentea klp-33 kinesin like protein 45(a)   II(7842340-7845306)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KAR36
    Minus-end-directed microtubule motor that function...
    25(a)
    1 → many
    XVI(815734-817923) YPR141C
    rice
    (Oryza sativa)
    Liliopsida Os.242202 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 75.62(n)    AK102894.1 


    ENSEMBL Gene Tree for KIFC3 (if available)
    TreeFam Gene Tree for KIFC3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KIFC3 gene
    KIFC22  KIFC12  KIF252  
    Selected SIMAP similar genes for KIFC3 using alignment to 19 protein entries:     KIFC3_HUMAN (see all proteins) (see all similar genes):
    DKFZp686D23201    A20    R11    R12    KIF5C    KIF3A
    KIF6    CENPE    KIF2C    KIF1A    KIF5B    KIF13B
    KIF5A    KIF27    KIF9    KIF23    KIFC1    KIF5B-ALK_K17

    KIFC3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KIFC3 (see all 1089)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1470807261,2
    C--57791670(+) GTCCTC/TGGCAC 3 -- int1 ds50010--------
    rs125961631,2
    C,F,H--57791767(+) GTAACC/GTGGAA 3 -- ds5001 int15Minor allele frequency- G:0.00NS EA NA 422
    rs1880292501,2
    --57791978(+) TGTTTA/GTTAAG 3 -- int1 ds50010--------
    rs1145131141,2
    C,F--57792104(+) GGCTCA/GCAGAC 3 -- ds5001 int11Minor allele frequency- G:0.07WA 118
    rs609556591,2
    C--57792133(+) CTTGTG/ATAAAA 3 -- ut313Minor allele frequency- A:0.14CSA WA EA 240
    rs1809588711,2
    --57792156(+) TTTTAA/GTAAGT 3 -- ut310--------
    rs727955331,2
    --57792318(+) GAGGCC/TATGCG 3 -- ut310--------
    rs1413718651,2
    C--57792333(+) GCACA-/CCCCCC 3 -- ut310--------
    rs581079171,2
    C--57792334(+) CACAC-/CCCCCC 3 -- ut310--------
    rs1477135481,2
    --57792371(+) AGGGGC/TGGGGA 3 -- ut310--------

    HapMap Linkage Disequilibrium report for KIFC3 (57792129 - 57896957 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for KIFC3 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509622CNV Insertion20534489
    nsv526855CNV Loss19592680
    dgv2873n71CNV Loss21882294
    nsv471089CNV Loss18288195
    nsv528250CNV Loss19592680
    nsv523237CNV Loss19592680
    dgv2872n71CNV Loss21882294
    dgv2874n71CNV Loss21882294
    nsv906729CNV Loss21882294
    nsv817732CNV Loss17921354

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KIFC3
    DNA2.0 Custom Variant and Variant Library Synthesis for KIFC3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604535    OMIM disorders: --

    4 diseases for KIFC3:    About MalaCards
    bardet-biedl syndrome    primary biliary cirrhosis    retinitis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for KIFC3:
    Bardet-Biedl syndrome

    KIFC3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KIFC3
    Human Genome Epidemiology (HuGE) Navigator: KIFC3 (3 documents)

    Export disorders for KIFC3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KIFC3 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with KIFC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a novel C-terminal kinesin (KIFC3) that maps to human chromosome 16q13-q21 and thus is a candidate gene for Bardet-Biedl syndrome. (PubMed id 9782090)1, 2, 3 Hoang E.H.... Burnside B. (Genomics 1998)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contacts. (PubMed id 19041755)1, 2 Meng W.... Takeichi M. (Cell 2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    7. Identification of the kinesin KifC3 as a new player for positioning of peroxisomes and other organelles in mammalian cells. (PubMed id 23954441)1 Dietrich D....Dodt G. (Biochim. Biophys. Acta 2013)
    8. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    9. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    10. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3801 HGNC: 6326 AceView: KIFC3 Ensembl:ENSG00000140859 euGenes: HUgn3801
    ECgene: KIFC3 H-InvDB: KIFC3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KIFC3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KIFC3 gene:
    Search GeneIP for patents involving KIFC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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