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Aliases for KIFC2 Gene

Aliases for KIFC2 Gene

  • Kinesin Family Member C2 2 3 5

External Ids for KIFC2 Gene

Previous GeneCards Identifiers for KIFC2 Gene

  • GC08P145296
  • GC08P145696
  • GC08P145662
  • GC08P140804
  • GC08P145691

Summaries for KIFC2 Gene

GeneCards Summary for KIFC2 Gene

KIFC2 (Kinesin Family Member C2) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Factors involved in megakaryocyte development and platelet production. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIFC3.

UniProtKB/Swiss-Prot for KIFC2 Gene

  • May play a role in microtubule-dependent retrograde axonal transport. May function as the motor for the transport of multivesicular body (MVB)-like organelles in dendrites (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIFC2 Gene

Genomics for KIFC2 Gene

Regulatory Elements for KIFC2 Gene

Enhancers for KIFC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F144785 1.2 ENCODE 8.6 +323.7 323688 9.0 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 RPL8 C8orf82 ZNF34 VPS28 ZNF517 PARP10 COMMD5 C8orf33 ZNF251 ARHGAP39
GH08F144334 0.9 FANTOM5 8.9 -130.8 -130805 0.6 USF1 SUZ12 MAX BCL11B ZFHX2 POLR2A SCRT2 PRDM10 EZH2 EGR2 SCRT1 KIFC2 LRRC24 ZNF252P ZNF34 ZNF517 CYHR1 DGAT1
GH08F144322 1.1 ENCODE 5.6 -141.0 -141008 5.5 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 KLF13 C8orf82 BOP1 ZNF517 C8orf33 ARHGAP39 DGAT1 KIFC2 MIR6848 ENSG00000254690
GH08F144683 1.7 FANTOM5 Ensembl ENCODE 2.1 +219.9 219890 4.5 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF143 SP3 SP5 C8orf82 ZNF34 RECQL4 ADCK5 ZNF252P RPL8 SCRT1 ARHGAP39 KIFC2 LRRC24
GH08F144620 0.9 FANTOM5 Ensembl ENCODE 1.5 +155.8 155824 2.5 ZIC2 ZNF34 SLC39A4 SCRT1 ARHGAP39 KIFC2 GC08M144645 ENSG00000255456
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KIFC2 on UCSC Golden Path with GeneCards custom track

Promoters for KIFC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001404434 57 2601 ATF1 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 ZNF121 GLIS2 ZNF143

Genomic Location for KIFC2 Gene

Chromosome:
8
Start:
144,466,043 bp from pter
End:
144,474,202 bp from pter
Size:
8,160 bases
Orientation:
Plus strand

Genomic View for KIFC2 Gene

Genes around KIFC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIFC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIFC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIFC2 Gene

Proteins for KIFC2 Gene

  • Protein details for KIFC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AC6-KIFC2_HUMAN
    Recommended name:
    Kinesin-like protein KIFC2
    Protein Accession:
    Q96AC6
    Secondary Accessions:
    • E9PHB2
    • Q96NN6

    Protein attributes for KIFC2 Gene

    Size:
    838 amino acids
    Molecular mass:
    90147 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KIFC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIFC2 Gene

Post-translational modifications for KIFC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIFC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KIFC2 Gene

Domains & Families for KIFC2 Gene

Gene Families for KIFC2 Gene

Protein Domains for KIFC2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96AC6

UniProtKB/Swiss-Prot:

KIFC2_HUMAN :
  • Contains 1 kinesin motor domain.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Domain:
  • Contains 1 kinesin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIFC2: view

Function for KIFC2 Gene

Molecular function for KIFC2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in microtubule-dependent retrograde axonal transport. May function as the motor for the transport of multivesicular body (MVB)-like organelles in dendrites (By similarity).

Gene Ontology (GO) - Molecular Function for KIFC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity IBA --
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
GO:0016887 ATPase activity IBA --
genes like me logo Genes that share ontologies with KIFC2: view
genes like me logo Genes that share phenotypes with KIFC2: view

Animal Models for KIFC2 Gene

MGI Knock Outs for KIFC2:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KIFC2 Gene

Localization for KIFC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIFC2 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIFC2 gene
Compartment Confidence
cytoskeleton 4
cytosol 4
nucleus 3
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KIFC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005871 kinesin complex IBA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with KIFC2: view

Pathways & Interactions for KIFC2 Gene

genes like me logo Genes that share pathways with KIFC2: view

Gene Ontology (GO) - Biological Process for KIFC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007018 microtubule-based movement IBA --
genes like me logo Genes that share ontologies with KIFC2: view

No data available for SIGNOR curated interactions for KIFC2 Gene

Transcripts for KIFC2 Gene

Unigene Clusters for KIFC2 Gene

Kinesin family member C2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIFC2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c ^ 18a ·
SP1: - -
SP2: - - - - - -
SP3:
SP4:
SP5:
SP6:
SP7:

ExUns: 18b ^ 19a · 19b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for KIFC2 Gene

GeneLoc Exon Structure for
KIFC2
ECgene alternative splicing isoforms for
KIFC2

Expression for KIFC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KIFC2 Gene

mRNA differential expression in normal tissues according to GTEx for KIFC2 Gene

This gene is overexpressed in Brain - Cerebellum (x4.1).

Protein differential expression in normal tissues from HIPED for KIFC2 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KIFC2 Gene



Protein tissue co-expression partners for KIFC2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KIFC2 Gene:

KIFC2

SOURCE GeneReport for Unigene cluster for KIFC2 Gene:

Hs.528713
genes like me logo Genes that share expression patterns with KIFC2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for KIFC2 Gene

Orthologs for KIFC2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KIFC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIFC2 34 35
  • 99.1 (n)
cow
(Bos Taurus)
Mammalia KIFC2 34 35
  • 85.71 (n)
dog
(Canis familiaris)
Mammalia KIFC2 34 35
  • 84.41 (n)
rat
(Rattus norvegicus)
Mammalia Kifc2 34
  • 80.91 (n)
mouse
(Mus musculus)
Mammalia Kifc2 34 16 35
  • 80.89 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 68 (a)
OneToMany
-- 35
  • 65 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia KIFC2 35
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIFC2 35
  • 34 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii KIFC2 35
  • 32 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ncd 35
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea klp-3 35
  • 26 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KAR3 35
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
OneToMany
Species where no ortholog for KIFC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KIFC2 Gene

ENSEMBL:
Gene Tree for KIFC2 (if available)
TreeFam:
Gene Tree for KIFC2 (if available)

Paralogs for KIFC2 Gene

Paralogs for KIFC2 Gene

genes like me logo Genes that share paralogs with KIFC2: view

Variants for KIFC2 Gene

Sequence variations from dbSNP and Humsavar for KIFC2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs765146615 Likely benign 144,474,472(+) ACCAC(A/G)TTGGG downstream-variant-500B, reference, synonymous-codon
rs115750264 Benign 144,474,565(+) GCGGT(A/G/T)CCCTG downstream-variant-500B, reference, synonymous-codon
rs151147114 Benign 144,474,553(+) CCCCC(A/G)GGAAC downstream-variant-500B, reference, synonymous-codon
rs2721176 Benign 144,474,218(+) AGGAG(C/T)GGCCC intron-variant, downstream-variant-500B, utr-variant-3-prime
rs7833404 Benign 144,474,259(+) GAGAG(C/T)AGCCA downstream-variant-500B, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for KIFC2 Gene

Variant ID Type Subtype PubMed ID
nsv831489 CNV loss 17160897
nsv612947 CNV loss 21841781
nsv612946 CNV loss 21841781
nsv612940 CNV loss 21841781
nsv612936 CNV loss 21841781
nsv515809 CNV gain+loss 19592680
nsv470249 CNV loss 18288195
nsv428208 CNV gain 18775914
nsv1077079 CNV deletion 25765185
esv29999 CNV loss 17803354
esv2759652 CNV gain+loss 17122850
esv26548 CNV gain 19812545
dgv907n27 CNV loss 19166990
dgv12440n54 CNV loss 21841781
dgv12439n54 CNV loss 21841781
dgv12434n54 CNV loss 21841781

Variation tolerance for KIFC2 Gene

Residual Variation Intolerance Score: 58.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.05; 50.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIFC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIFC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIFC2 Gene

Disorders for KIFC2 Gene

Relevant External Links for KIFC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIFC2

No disorders were found for KIFC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIFC2 Gene

Publications for KIFC2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Characterization of KIFC2, a neuronal kinesin superfamily member in mouse. (PMID: 9115737) Hanlon D.W. … Goldstein L.S. (Neuron 1997) 2 3 64
  4. Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. (PMID: 25201988) Rietveld C.A. … Koellinger P.D. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3 64
  5. Kinesin family member 2C (KIF2C/MCAK) is a novel marker for prognosis in human gliomas. (PMID: 22130050) Bie L. … Zhang B. (Clin Neurol Neurosurg 2012) 3 64

Products for KIFC2 Gene

Sources for KIFC2 Gene

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