KIFC2 Gene
protein-coding GIFtS: 48
GCID: GC08P145691
|
|
kinesin family member C2
| |
Aliases
for KIFC2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Kinesin Family Member C21 2 | | Kinesin-Like Protein KIFC22 |
Export aliases for KIFC2 gene to outside databasesPrevious GC identifers: GC08P145296 GC08P145696 GC08P145662 GC08P140804 |
Summaries
for KIFC2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: KIFC2_HUMAN, Q96AC6Function: May play a role in microtubule-dependent retrograde axonal transport. May function as the motor for thetransport of multivesicular body (MVB)-like organelles in dendrites (By similarity)
|
Genomic Views
for KIFC2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_037704.5
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KIFC2 gene promoter:
Pax-5 Sp1 AP-2beta AP-2gamma AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for KIFC2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIFC2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q24.3 Ensembl cytogenetic band: 8q24.3 HGNC cytogenetic band: 8q24.3KIFC2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P145691: view genomic region
(about GC identifiers)
Start:
|
145,691,426 bp from pter |
End:
|
145,699,585 bp from pter |
Size:
|
8,160 bases |
Orientation:
|
plus strand |
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Proteins
for KIFC2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KIFC2_HUMAN, Q96AC6 (See
protein sequence)Recommended Name: Kinesin-like protein KIFC2 Size: 838 amino acids; 90147 Da
Subcellular location: Cytoplasm, cytoskeleton (Probable)Explore the universe of human proteins at neXtProt for KIFC2: NX_Q96AC6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96AC6
KIFC2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_665697.1
ENSEMBL proteins: ENSP00000301332 ENSP00000434398 ENSP00000301331
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
KIFC2 for ontologies About GeneDecksing
KIFC2 Antibody Products:
Assay Products for KIFC2: |
Protein
Domains /
Families
for KIFC2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KIFC2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96AC6ProtoNet protein and cluster: Q96AC6 1 Blocks protein family: IPB001752 Kinesin
UniProtKB/Swiss-Prot: KIFC2_HUMAN, Q96AC6Similarity: Belongs to the kinesin-like protein familySimilarity: Contains 1 kinesin-motor domain |
Function
for KIFC2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KIFC2_HUMAN, Q96AC6Function: May play a role in microtubule-dependent retrograde axonal transport. May function as the motor for thetransport of multivesicular body (MVB)-like organelles in dendrites (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIFC2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIFC2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: KIFC2 (NM_145754) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KIFC2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIFC2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIFC2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003777 | microtubule motor activity |
IEA | -- | | GO:0005524 | ATP binding |
IEA | -- |
KIFC2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for KIFC2:
Animal Models:
Mouse knock-out Kifc2tm1Gsn for KIFC2
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Kifc2):
KIFC2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for KIFC2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIFC2
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5/7 Interacting proteins for KIFC2 (Q96AC62, 3 ENSP000003013324) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007018 | microtubule-based movement |
IEA | -- |
KIFC2 for ontologies About GeneDecksing
|
Drugs & Compounds
for KIFC2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KIFC2
Search CenterWatch for drugs/clinical trials and news about KIFC2
|
Transcripts
for KIFC2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KIFC2 gene: NM_145754.2 Unigene Cluster for KIFC2: Kinesin family member C2 Hs.528713 [show with all ESTs]Unigene Representative Sequence: BC0173118 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000301332(uc003zcz.3) ENST00000529644 ENST00000533114 ENST00000528415
ENST00000529864 ENST00000531425 ENST00000531423 ENST00000301331
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIFC2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIFC2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KIFC2 (NM_145754) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KIFC2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIFC2 |
Additional cDNA sequence: AK055045.1 AY007121.1 BC015171.2 BC017311.2 10 DOTS entries: DT.97785833 DT.95133066 DT.100752493 DT.95323866 DT.453938 DT.91732695 DT.100675847 DT.40118402 DT.120641831 DT.99959529 24/86 AceView cDNA sequences (see all 86): CA406663 AW059702 AI571024 BI820749 AY007121 NM_145754 BF515031 BQ721298 AW262832 BM765794 BE886898 CK429241 BC015171 BM673552 CK430445 AK055045 AW590112 AI368915 AA292309 BC017311 BM843035 BI597561 BM742649 AA394109
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for KIFC2 (see all 7) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17a | · | 17b | · | 17c | ^ | 18a | · |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | - | | | | | | - | | - | | - | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 18b | ^ | 19a | · | 19b |
|---|
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| SP1: | | | | | | | |
| SP2: | | | | | | | |
| SP3: | | | | | | | |
| SP4: | | | | | | | |
| SP5: | | | | | | |
ECgene alternative splicing isoforms for KIFC2
|
Expression
for KIFC2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KIFC2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGTGGGGTGG
About this image
See KIFC2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KIFC2
SOURCE GeneReport for Unigene cluster: Hs.528713
SABiosciences Custom PCR Arrays for KIFC2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIFC2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KIFC2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIFC2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIFC2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIFC2 |
Orthologs
for KIFC2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for KIFC2 gene from 5/16 species (see all 16) About this table
ENSEMBL Gene Tree for KIFC2 (if available)
TreeFam Gene Tree for KIFC2 (if available) |
Paralogs
for KIFC2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KIFC2 gene
- KIFC12 KIFC32 KIF252
4 SIMAP similar genes for KIFC2 using alignment to 4 protein entries: KIFC2_HUMAN (see all proteins):KIF5C DKFZp686D23201 KIF6 KIFC3
KIFC2 for paralogs About GeneDecksing
|
Genomic Variants
for KIFC2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KIFC2 (145691426 - 145699585 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for KIFC2
6 CNVs: 70492 4613 3752 23292 53129 30306 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIFC2 |
|
Disorders
/ Diseases
for KIFC2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KIFC2 for disorders About GeneDecksing
1  disease for KIFC2: About MalaCardsneuronitis
Export disorders for KIFC2 gene to outside databases
|
Publications
for KIFC2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KIFC2 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with KIFC2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Characterization of KIFC2, a neuronal kinesin superfamily member in mouse. (PubMed id 9115737)1, 3 Hanlon D.W....Goldstein L.S. (1997)
- Kinesin family member 2C (KIF2C/MCAK) is a novel marke r for prognosis in human gliomas. (PubMed id 22130050)1 Bie L....Zhang B. (2012)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)1 Wu C....Li S.S. (2007)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1 Yu W.... Gibbs R.A. (1997)
- A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1 Andersson B.... Gibbs R.A. (1996)
|
External Searches for KIFC2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KIFC2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KIFC2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KIFC2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KIFC2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KIFC2 gene:
Search GeneIP for patents involving KIFC2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KIFC2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KIFC2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KIFC2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIFC2 | | | OriGene Protein Over-expression Lysate for KIFC2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for KIFC2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIFC2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIFC2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KIFC2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIFC2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIFC2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIFC2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIFC2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIFC2 |
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 | | | KIFC2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIFC2 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIFC2 |
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