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Aliases for KIFC2 Gene

Aliases for KIFC2 Gene

  • Kinesin Family Member C2 2 3

External Ids for KIFC2 Gene

Previous GeneCards Identifiers for KIFC2 Gene

  • GC08P145296
  • GC08P145696
  • GC08P145662
  • GC08P140804
  • GC08P145691

Summaries for KIFC2 Gene

GeneCards Summary for KIFC2 Gene

KIFC2 (Kinesin Family Member C2) is a Protein Coding gene. GO annotations related to this gene include microtubule binding and microtubule motor activity. An important paralog of this gene is KIFC1.

UniProtKB/Swiss-Prot for KIFC2 Gene

  • May play a role in microtubule-dependent retrograde axonal transport. May function as the motor for the transport of multivesicular body (MVB)-like organelles in dendrites (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIFC2 Gene

Genomics for KIFC2 Gene

Regulatory Elements for KIFC2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KIFC2 Gene

Start:
144,466,043 bp from pter
End:
144,474,202 bp from pter
Size:
8,160 bases
Orientation:
Plus strand

Genomic View for KIFC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIFC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIFC2 Gene

Proteins for KIFC2 Gene

  • Protein details for KIFC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AC6-KIFC2_HUMAN
    Recommended name:
    Kinesin-like protein KIFC2
    Protein Accession:
    Q96AC6
    Secondary Accessions:
    • E9PHB2
    • Q96NN6

    Protein attributes for KIFC2 Gene

    Size:
    838 amino acids
    Molecular mass:
    90147 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KIFC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIFC2 Gene

Proteomics data for KIFC2 Gene at MOPED

Post-translational modifications for KIFC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIFC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KIFC2 Gene

Domains for KIFC2 Gene

Gene Families for KIFC2 Gene

HGNC:
  • KIF :Kinesins

Protein Domains for KIFC2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96AC6

UniProtKB/Swiss-Prot:

KIFC2_HUMAN :
  • Q96AC6
Domain:
  • Contains 1 kinesin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIFC2: view

Function for KIFC2 Gene

Molecular function for KIFC2 Gene

UniProtKB/Swiss-Prot Function: May play a role in microtubule-dependent retrograde axonal transport. May function as the motor for the transport of multivesicular body (MVB)-like organelles in dendrites (By similarity).

Gene Ontology (GO) - Molecular Function for KIFC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity IBA --
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
GO:0016887 ATPase activity IBA --
genes like me logo Genes that share ontologies with KIFC2: view

Phenotypes for KIFC2 Gene

MGI mutant phenotypes for KIFC2:
inferred from 1 alleles
GenomeRNAi human phenotypes for KIFC2:
genes like me logo Genes that share phenotypes with KIFC2: view

Animal Models for KIFC2 Gene

MGI Knock Outs for KIFC2:

Animal Model Products

CRISPR Products

miRNA for KIFC2 Gene

miRTarBase miRNAs that target KIFC2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for KIFC2 Gene

Localization for KIFC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIFC2 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIFC2 Gene COMPARTMENTS Subcellular localization image for KIFC2 gene
Compartment Confidence
cytoskeleton 4
cytosol 3
endosome 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KIFC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005871 kinesin complex IBA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with KIFC2: view

Pathways for KIFC2 Gene

SuperPathways for KIFC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KIFC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0007018 microtubule-based movement IBA --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with KIFC2: view

No data available for Pathways by source for KIFC2 Gene

Transcripts for KIFC2 Gene

Unigene Clusters for KIFC2 Gene

Kinesin family member C2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIFC2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KIFC2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIFC2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c ^ 18a ·
SP1: - -
SP2: - - - - - -
SP3:
SP4:
SP5:
SP6:
SP7:

ExUns: 18b ^ 19a · 19b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for KIFC2 Gene

GeneLoc Exon Structure for
KIFC2
ECgene alternative splicing isoforms for
KIFC2

Expression for KIFC2 Gene

mRNA expression in normal human tissues for KIFC2 Gene

mRNA differential expression in normal tissues according to GTEx for KIFC2 Gene

This gene is overexpressed in Brain - Cerebellum (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KIFC2 Gene

SOURCE GeneReport for Unigene cluster for KIFC2 Gene Hs.528713

genes like me logo Genes that share expressions with KIFC2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for KIFC2 Gene

Orthologs for KIFC2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KIFC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIFC2 35
  • 99.1 (n)
  • 98.72 (a)
KIFC2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIFC2 35
  • 85.71 (n)
  • 85.29 (a)
KIFC2 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIFC2 35
  • 84.41 (n)
  • 83.89 (a)
KIFC2 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kifc2 35
  • 80.89 (n)
  • 82.82 (a)
Kifc2 16
Kifc2 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIFC2 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Kifc2 35
  • 80.91 (n)
  • 82.93 (a)
lizard
(Anolis carolinensis)
Reptilia KIFC2 36
  • 34 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii KIFC2 36
  • 32 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ncd 36
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea klp-3 36
  • 26 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KAR3 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for KIFC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KIFC2 Gene

ENSEMBL:
Gene Tree for KIFC2 (if available)
TreeFam:
Gene Tree for KIFC2 (if available)

Paralogs for KIFC2 Gene

Paralogs for KIFC2 Gene

genes like me logo Genes that share paralogs with KIFC2: view

Variants for KIFC2 Gene

Sequence variations from dbSNP and Humsavar for KIFC2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1564415 -- 144,470,591(-) GGGCT(C/G)TCAGC intron-variant
rs1564416 -- 144,470,067(-) GGCTG(A/G)GGCTG intron-variant
rs2250657 -- 144,468,337(-) GCCTC(C/T)GCCTC reference, synonymous-codon
rs2306382 -- 144,469,886(-) GGGCA(A/G)ACCCT intron-variant
rs2620671 -- 144,472,866(-) GTCTC(C/T)CCGCG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for KIFC2 Gene

Variant ID Type Subtype PubMed ID
nsv470249 CNV Loss 18288195
nsv515809 CNV Gain+Loss 19592680
nsv891807 CNV Loss 21882294
nsv428208 CNV Gain 18775914
nsv891817 CNV Loss 21882294
dgv7959n71 CNV Loss 21882294
nsv891841 CNV Loss 21882294
nsv891845 CNV Gain 21882294
nsv891846 CNV Loss 21882294
dgv2264e1 CNV Complex 17122850
nsv831489 CNV Loss 17160897
dgv7966n71 CNV Loss 21882294
dgv7968n71 CNV Loss 21882294
dgv7969n71 CNV Loss 21882294
dgv7971n71 CNV Loss 21882294
dgv7972n71 CNV Loss 21882294
dgv907n27 CNV Loss 19166990
nsv891887 CNV Gain 21882294
dgv7975n71 CNV Loss 21882294
dgv7976n71 CNV Loss 21882294
dgv7977n71 CNV Loss 21882294
dgv7978n71 CNV Loss 21882294
nsv891897 CNV Loss 21882294
esv29999 CNV Loss 17803354
dgv7979n71 CNV Loss 21882294
esv26548 CNV Gain 19812545
dgv7980n71 CNV Loss 21882294

Relevant External Links for KIFC2 Gene

HapMap Linkage Disequilibrium report
KIFC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIFC2 Gene

Disorders for KIFC2 Gene

No disorders were found for KIFC2 Gene.

No data available for UniProtKB/Swiss-Prot for KIFC2 Gene

Publications for KIFC2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Characterization of KIFC2, a neuronal kinesin superfamily member in mouse. (PMID: 9115737) Hanlon D.W. … Goldstein L.S. (Neuron 1997) 2 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Identification, partial characterization, and genetic mapping of kinesin-like protein genes in mouse. (PMID: 9339368) Yang Z. … Goldstein L.S. (Genomics 1997) 23

Products for KIFC2 Gene

Sources for KIFC2 Gene

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