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Aliases for KIFC1 Gene

Aliases for KIFC1 Gene

  • Kinesin Family Member C1 2 3
  • KNSL2 3 4 6
  • HSET 3 4 6
  • Kinesin-Related Protein HSET 3 4
  • Kinesin-Like Protein 2 3 4
  • Kinesin-Like 2 2 3
  • Kinesin-Like Protein KIFC1 3

External Ids for KIFC1 Gene

Previous HGNC Symbols for KIFC1 Gene

  • KNSL2

Previous GeneCards Identifiers for KIFC1 Gene

  • GC06P033355
  • GC06P033406
  • GC06P033466
  • GC06P033101

Summaries for KIFC1 Gene

GeneCards Summary for KIFC1 Gene

KIFC1 (Kinesin Family Member C1) is a Protein Coding gene. Among its related pathways are Hemostasis and Cytoskeletal Signaling. GO annotations related to this gene include microtubule binding and microtubule motor activity. An important paralog of this gene is KIFC3.

UniProtKB/Swiss-Prot for KIFC1 Gene

  • Minus end-directed microtubule-dependent motor required for bipolar spindle formation. May contribute to movement of early endocytic vesicles.

Gene Wiki entry for KIFC1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIFC1 Gene

Genomics for KIFC1 Gene

Regulatory Elements for KIFC1 Gene

Genomic Location for KIFC1 Gene

Start:
33,391,536 bp from pter
End:
33,409,924 bp from pter
Size:
18,389 bases
Orientation:
Plus strand

Genomic View for KIFC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIFC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for KIFC1 Gene

  • Protein details for KIFC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BW19-KIFC1_HUMAN
    Recommended name:
    Kinesin-like protein KIFC1
    Protein Accession:
    Q9BW19
    Secondary Accessions:
    • O60887
    • Q14834
    • Q4KMP0
    • Q5SU09
    • Q6GMS7
    • Q6P4A5
    • Q9UQP7

    Protein attributes for KIFC1 Gene

    Size:
    673 amino acids
    Molecular mass:
    73748 Da
    Quaternary structure:
    • Binds NUBP1 and NUBP2. Interacts with PPP1R42 (By similarity).
    Miscellaneous:
    • HeLa cells lacking KIFC1 show multipolar mitotic spindles and a defect in chromosome congression and chromosome alignment during mitosis
    SequenceCaution:
    • Sequence=AAH00712.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH63567.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH73878.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH98438.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA03509.1; Type=Frameshift; Positions=223, 256; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KIFC1 Gene

neXtProt entry for KIFC1 Gene

Proteomics data for KIFC1 Gene at MOPED

Post-translational modifications for KIFC1 Gene

  • Ubiquitination at Lys308, Lys511, Lys619, and Lys659
  • Modification sites at PhosphoSitePlus

Other Protein References for KIFC1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KIFC1 Gene

Domains for KIFC1 Gene

Gene Families for KIFC1 Gene

HGNC:
  • KIF :Kinesins

Protein Domains for KIFC1 Gene

Suggested Antigen Peptide Sequences for KIFC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BW19

UniProtKB/Swiss-Prot:

KIFC1_HUMAN :
  • Q9BW19
Domain:
  • Contains 1 kinesin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. NCD subfamily.
genes like me logo Genes that share domains with KIFC1: view

Function for KIFC1 Gene

Molecular function for KIFC1 Gene

UniProtKB/Swiss-Prot Function: Minus end-directed microtubule-dependent motor required for bipolar spindle formation. May contribute to movement of early endocytic vesicles.

Gene Ontology (GO) - Molecular Function for KIFC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity NAS 8276466
GO:0005524 ATP binding NAS 8276466
GO:0008017 microtubule binding IEA --
GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed IBA --
GO:0016887 ATPase activity IBA --
genes like me logo Genes that share ontologies with KIFC1: view
genes like me logo Genes that share phenotypes with KIFC1: view

miRNA for KIFC1 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KIFC1 Gene

Localization for KIFC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIFC1 Gene

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Early endosome. Note=Associated with nucleus during interphase, centrosomes in early and spindle in later mitosis. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIFC1 Gene COMPARTMENTS Subcellular localization image for KIFC1 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
endosome 2
nucleus 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for KIFC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005768 endosome --
GO:0005769 early endosome IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005819 spindle IEA --
genes like me logo Genes that share ontologies with KIFC1: view

Pathways for KIFC1 Gene

genes like me logo Genes that share pathways with KIFC1: view

Pathways by source for KIFC1 Gene

1 Cell Signaling Technology pathway for KIFC1 Gene

Gene Ontology (GO) - Biological Process for KIFC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000070 mitotic sister chromatid segregation NAS 8276466
GO:0006200 obsolete ATP catabolic process --
GO:0007018 microtubule-based movement TAS --
GO:0007080 mitotic metaphase plate congression IMP 15843429
GO:0007596 blood coagulation TAS --
genes like me logo Genes that share ontologies with KIFC1: view

Compounds for KIFC1 Gene

(1) HMDB Compounds for KIFC1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5

(1) Drugbank Compounds for KIFC1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Adenosine-5'-Diphosphate
20398-34-9 target
genes like me logo Genes that share compounds with KIFC1: view

Transcripts for KIFC1 Gene

Unigene Clusters for KIFC1 Gene

Kinesin family member C1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIFC1 Gene

No ASD Table

Relevant External Links for KIFC1 Gene

GeneLoc Exon Structure for
KIFC1
ECgene alternative splicing isoforms for
KIFC1

Expression for KIFC1 Gene

mRNA expression in normal human tissues for KIFC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIFC1 Gene

This gene is overexpressed in Testis (4.6) and Esophagus - Mucosa (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIFC1 Gene

SOURCE GeneReport for Unigene cluster for KIFC1 Gene Hs.436912

genes like me logo Genes that share expressions with KIFC1: view

No data available for mRNA Expression by UniProt/SwissProt for KIFC1 Gene

Orthologs for KIFC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KIFC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIFC1 35
  • 99.6 (n)
  • 99.55 (a)
KIFC1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIFC1 35
  • 86.67 (n)
  • 86.57 (a)
KIFC1 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIFC1 35
  • 86.31 (n)
  • 87.2 (a)
KIFC1 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kifc1 35
  • 80.97 (n)
  • 80.12 (a)
Kifc1 16
Kifc1 36
  • 80 (a)
OneToMany
Kifc5b 36
  • 78 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia KIFC1 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIFC1 36
  • 31 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kifc1 35
  • 81.21 (n)
  • 79.91 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 42 (a)
OneToMany
-- 36
  • 54 (a)
OneToMany
KIFC1 35
  • 59.11 (n)
  • 56.67 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 39 (a)
OneToMany
-- 36
  • 39 (a)
OneToMany
-- 36
  • 49 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia kifc1 35
  • 53.54 (n)
  • 51.64 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
kifc1 35
  • 53.58 (n)
  • 51.93 (a)
kifc1 36
  • 44 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002248 35
  • 47.7 (n)
  • 38.78 (a)
fruit fly
(Drosophila melanogaster)
Insecta ncd 35
  • 48.87 (n)
  • 40.14 (a)
worm
(Caenorhabditis elegans)
Secernentea klp-17 36
  • 31 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KAR3 36
  • 29 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ATK5 35
  • 51.06 (n)
  • 49.26 (a)
rice
(Oryza sativa)
Liliopsida Os04g0629700 35
  • 49.12 (n)
  • 47.16 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04581 35
  • 50.95 (n)
  • 43.67 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11354 36
  • 47 (a)
ManyToMany
Species with no ortholog for KIFC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIFC1 Gene

ENSEMBL:
Gene Tree for KIFC1 (if available)
TreeFam:
Gene Tree for KIFC1 (if available)

Paralogs for KIFC1 Gene

Paralogs for KIFC1 Gene

Selected SIMAP similar genes for KIFC1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KIFC1: view

Variants for KIFC1 Gene

Sequence variations from dbSNP and Humsavar for KIFC1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs169817 -- 33,393,947(+) ttcac(C/T)gcgtt intron-variant
rs172435 -- 33,392,043(+) GACGA(A/C)GGCTG intron-variant
rs211457 -- 33,397,863(+) GGTTA(C/T)GTCCT intron-variant
rs211458 -- 33,397,576(+) caggc(A/G)taagc intron-variant
rs211459 -- 33,397,548(+) acctc(C/T)gcctc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIFC1 Gene

Variant ID Type Subtype PubMed ID
nsv830635 CNV Loss 17160897
nsv830637 CNV Loss 17160897
nsv885769 CNV Loss 21882294

Relevant External Links for KIFC1 Gene

HapMap Linkage Disequilibrium report
KIFC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIFC1 Gene

Disorders for KIFC1 Gene

Relevant External Links for KIFC1

Genetic Association Database (GAD)
KIFC1
Human Genome Epidemiology (HuGE) Navigator
KIFC1
genes like me logo Genes that share disorders with KIFC1: view

No data available for UniProtKB/Swiss-Prot for KIFC1 Gene

Publications for KIFC1 Gene

  1. Cloning of a new kinesin-related gene located at the centromeric end of the human MHC region. (PMID: 8276466) Ando A. … Inoko H. (Immunogenetics 1994) 2 3 4 23
  2. Genomic organization of the HSET locus and the possible association of HLA-linked genes with immotile cilia syndrome (ICS). (PMID: 10369922) Janitz K. … Volz A. (Immunogenetics 1999) 3 4 23
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference. (PMID: 15843429) Zhu C. … Jiang W. (Mol. Biol. Cell 2005) 3 4

Products for KIFC1 Gene

Sources for KIFC1 Gene

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