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Aliases for KIFC1 Gene

Aliases for KIFC1 Gene

  • Kinesin Family Member C1 2 3 5
  • Kinesin-Related Protein HSET 3 4
  • Kinesin-Like Protein 2 3 4
  • Kinesin-Like 2 2 3
  • KNSL2 3 4
  • HSET 3 4
  • Kinesin-Like Protein KIFC1 3

External Ids for KIFC1 Gene

Previous HGNC Symbols for KIFC1 Gene

  • KNSL2

Previous GeneCards Identifiers for KIFC1 Gene

  • GC06P033355
  • GC06P033406
  • GC06P033466
  • GC06P033101

Summaries for KIFC1 Gene

GeneCards Summary for KIFC1 Gene

KIFC1 (Kinesin Family Member C1) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Factors involved in megakaryocyte development and platelet production. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIFC3.

UniProtKB/Swiss-Prot for KIFC1 Gene

  • Minus end-directed microtubule-dependent motor required for bipolar spindle formation (PubMed:15843429). May contribute to movement of early endocytic vesicles (By similarity). Regulates cilium formation and structure (By similarity).

Gene Wiki entry for KIFC1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIFC1 Gene

Genomics for KIFC1 Gene

Regulatory Elements for KIFC1 Gene

Enhancers for KIFC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F033362 0.2 ENCODE 11.8 -29.2 -29206 0.2 CUX1 DAXX KIFC1 RPL35AP4 HLA-DMA MIR5004 SYNGAP1 CUTA LYPLA2P1 MYL8P
GH06F033423 1.2 FANTOM5 ENCODE 11.4 +34.4 34441 3.9 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 YBX1 YY1 DAXX ZBTB9 KIFC1 RPL35AP4 VPS52 CUTA RPL35P2 WDR46 SYNGAP1 MIR5004
GH06F033428 0.7 FANTOM5 ENCODE 11.4 +37.6 37587 1.7 HDGF ATF1 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 YBX1 GLIS2 SMARCA4 ZBTB9 C6orf1 RPL35AP4 KIFC1 CUTA BAK1 SYNGAP1 MIR5004
GH06F033287 0.2 ENCODE 11.2 -102.0 -102007 3.1 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF207 TAPBP ZBTB22 KIFC1 PHF1 RPL35AP4 CUTA MIR5004 SYNGAP1 VPS52 RPS18
GH06F033430 1 FANTOM5 ENCODE 11 +40.9 40896 4.5 HDGF SIN3A ARID4B ZNF48 GLIS2 ELK1 FOS SP3 MEF2D RFX3 DAXX ZBTB9 C6orf1 PHF1 KIFC1 RPL35AP4 HLA-DMA CUTA BAK1 HLA-DPB1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around KIFC1 on UCSC Golden Path with GeneCards custom track

Promoters for KIFC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001137179 676 2001 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for KIFC1 Gene

Chromosome:
6
Start:
33,391,524 bp from pter
End:
33,410,226 bp from pter
Size:
18,703 bases
Orientation:
Plus strand

Genomic View for KIFC1 Gene

Genes around KIFC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIFC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIFC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIFC1 Gene

Proteins for KIFC1 Gene

  • Protein details for KIFC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BW19-KIFC1_HUMAN
    Recommended name:
    Kinesin-like protein KIFC1
    Protein Accession:
    Q9BW19
    Secondary Accessions:
    • O60887
    • Q14834
    • Q4KMP0
    • Q5SU09
    • Q6GMS7
    • Q6P4A5
    • Q9UQP7

    Protein attributes for KIFC1 Gene

    Size:
    673 amino acids
    Molecular mass:
    73748 Da
    Quaternary structure:
    • Binds NUBP1 and NUBP2. Interacts with PPP1R42 (By similarity).
    Miscellaneous:
    • HeLa cells lacking KIFC1 show multipolar mitotic spindles and a defect in chromosome congression and chromosome alignment during mitosis.
    SequenceCaution:
    • Sequence=AAH00712.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH63567.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH73878.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH98438.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA03509.1; Type=Frameshift; Positions=223, 256; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KIFC1 Gene

neXtProt entry for KIFC1 Gene

Post-translational modifications for KIFC1 Gene

  • Ubiquitination at Lys 308, Lys 511, Lys 619, and Lys 659
  • Modification sites at PhosphoSitePlus

Other Protein References for KIFC1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for KIFC1 (KIFC1)
  • Abcam antibodies for KIFC1
  • Santa Cruz Biotechnology (SCBT) Antibodies for KIFC1

No data available for DME Specific Peptides for KIFC1 Gene

Domains & Families for KIFC1 Gene

Gene Families for KIFC1 Gene

Protein Domains for KIFC1 Gene

Suggested Antigen Peptide Sequences for KIFC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BW19

UniProtKB/Swiss-Prot:

KIFC1_HUMAN :
  • Contains 1 kinesin motor domain.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. NCD subfamily.
Domain:
  • Contains 1 kinesin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. NCD subfamily.
genes like me logo Genes that share domains with KIFC1: view

Function for KIFC1 Gene

Molecular function for KIFC1 Gene

UniProtKB/Swiss-Prot Function:
Minus end-directed microtubule-dependent motor required for bipolar spindle formation (PubMed:15843429). May contribute to movement of early endocytic vesicles (By similarity). Regulates cilium formation and structure (By similarity).

Gene Ontology (GO) - Molecular Function for KIFC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003777 microtubule motor activity IEA,NAS 8276466
GO:0005524 ATP binding IEA,NAS 8276466
GO:0008017 microtubule binding IEA --
GO:0016887 ATPase activity IBA --
genes like me logo Genes that share ontologies with KIFC1: view
genes like me logo Genes that share phenotypes with KIFC1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIFC1 Gene

Localization for KIFC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIFC1 Gene

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Early endosome. Note=Associated with nucleus during interphase, centrosomes in early and spindle in later mitosis. {ECO:0000250 UniProtKB:Q9QWT9}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIFC1 Gene COMPARTMENTS Subcellular localization image for KIFC1 gene
Compartment Confidence
cytoskeleton 3
cytosol 3
nucleus 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for KIFC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IEA --
GO:0005769 early endosome IEA --
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with KIFC1: view

Pathways & Interactions for KIFC1 Gene

genes like me logo Genes that share pathways with KIFC1: view

Gene Ontology (GO) - Biological Process for KIFC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000070 mitotic sister chromatid segregation NAS 8276466
GO:0007018 microtubule-based movement IEA,IBA --
GO:0007049 cell cycle IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0007080 mitotic metaphase plate congression IMP 15843429
genes like me logo Genes that share ontologies with KIFC1: view

No data available for SIGNOR curated interactions for KIFC1 Gene

Drugs & Compounds for KIFC1 Gene

(1) Drugs for KIFC1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
genes like me logo Genes that share compounds with KIFC1: view

Transcripts for KIFC1 Gene

Unigene Clusters for KIFC1 Gene

Kinesin family member C1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIFC1 Gene

No ASD Table

Relevant External Links for KIFC1 Gene

GeneLoc Exon Structure for
KIFC1
ECgene alternative splicing isoforms for
KIFC1

Expression for KIFC1 Gene

mRNA expression in normal human tissues for KIFC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIFC1 Gene

This gene is overexpressed in Testis (x4.6) and Esophagus - Mucosa (x4.0).

Protein differential expression in normal tissues from HIPED for KIFC1 Gene

This gene is overexpressed in Breast (47.7), Testis (9.6), and NK cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KIFC1 Gene



NURSA nuclear receptor signaling pathways regulating expression of KIFC1 Gene:

KIFC1

SOURCE GeneReport for Unigene cluster for KIFC1 Gene:

Hs.436912
genes like me logo Genes that share expression patterns with KIFC1: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for KIFC1 Gene

Orthologs for KIFC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KIFC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIFC1 34 35
  • 99.6 (n)
cow
(Bos Taurus)
Mammalia KIFC1 34 35
  • 86.67 (n)
dog
(Canis familiaris)
Mammalia KIFC1 34 35
  • 86.31 (n)
rat
(Rattus norvegicus)
Mammalia Kifc1 34
  • 81.21 (n)
mouse
(Mus musculus)
Mammalia Kifc1 34 35
  • 80.97 (n)
Kifc5b 16 35
  • 78 (a)
oppossum
(Monodelphis domestica)
Mammalia KIFC1 35
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIFC1 35
  • 31 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIFC1 34
  • 59.11 (n)
-- 35
  • 54 (a)
OneToMany
-- 35
  • 42 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 49 (a)
OneToMany
-- 35
  • 39 (a)
OneToMany
-- 35
  • 39 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia kifc1 34
  • 53.54 (n)
zebrafish
(Danio rerio)
Actinopterygii kifc1 34 35
  • 53.58 (n)
-- 34
fruit fly
(Drosophila melanogaster)
Insecta ncd 34
  • 48.87 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002248 34
  • 47.7 (n)
worm
(Caenorhabditis elegans)
Secernentea klp-17 35
  • 31 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KAR3 35
  • 29 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ATK5 34
  • 51.06 (n)
rice
(Oryza sativa)
Liliopsida Os04g0629700 34
  • 49.12 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU04581 34
  • 50.95 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11354 35
  • 47 (a)
ManyToMany
Species where no ortholog for KIFC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIFC1 Gene

ENSEMBL:
Gene Tree for KIFC1 (if available)
TreeFam:
Gene Tree for KIFC1 (if available)

Paralogs for KIFC1 Gene

Variants for KIFC1 Gene

Sequence variations from dbSNP and Humsavar for KIFC1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10664999 -- 33,392,686(+) AAGGT(-/CTC)CTGCC intron-variant
rs111235617 -- 33,403,608(+) AAAAT(C/T)CATTT intron-variant
rs111461772 -- 33,406,176(+) TTGCC(A/C)CTTCT intron-variant
rs111510892 -- 33,392,685(+) AAAGG(-/CTC)TCTGC intron-variant
rs111623019 -- 33,401,719(+) TTTTT(A/T)GAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIFC1 Gene

Variant ID Type Subtype PubMed ID
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1119076 CNV deletion 24896259
nsv830635 CNV loss 17160897
nsv830637 CNV loss 17160897
nsv969387 CNV duplication 23825009

Variation tolerance for KIFC1 Gene

Residual Variation Intolerance Score: 63.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.18; 51.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIFC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIFC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIFC1 Gene

Disorders for KIFC1 Gene

Relevant External Links for KIFC1

Genetic Association Database (GAD)
KIFC1
Human Genome Epidemiology (HuGE) Navigator
KIFC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIFC1

No disorders were found for KIFC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIFC1 Gene

Publications for KIFC1 Gene

  1. Cloning of a new kinesin-related gene located at the centromeric end of the human MHC region. (PMID: 8276466) Ando A. … Inoko H. (Immunogenetics 1994) 2 3 4 22 64
  2. Genomic organization of the HSET locus and the possible association of HLA-linked genes with immotile cilia syndrome (ICS). (PMID: 10369922) Janitz K. … Volz A. (Immunogenetics 1999) 3 4 22 64
  3. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 46 64
  4. Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference. (PMID: 15843429) Zhu C. … Jiang W. (Mol. Biol. Cell 2005) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for KIFC1 Gene

Sources for KIFC1 Gene

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