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Aliases for KIFAP3 Gene

Aliases for KIFAP3 Gene

  • Kinesin-Associated Protein 3 2 3
  • SMAP 3 4 6
  • Smg GDS-Associated Protein 3 4
  • KAP-3 3 4
  • KAP3 3 4
  • Small G Protein GDP Dissociation Stimulator 3
  • DJ190I16.1 3
  • Smg GDS 2
  • Smg-GDS 3
  • KIF3AP 4
  • KAP-1 3
  • FLA3 3

External Ids for KIFAP3 Gene

Previous GeneCards Identifiers for KIFAP3 Gene

  • GC01M167519
  • GC01M165541
  • GC01M166586
  • GC01M167077
  • GC01M166622
  • GC01M168157
  • GC01M141112

Summaries for KIFAP3 Gene

Entrez Gene Summary for KIFAP3 Gene

  • The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

GeneCards Summary for KIFAP3 Gene

KIFAP3 (Kinesin-Associated Protein 3) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Hemostasis. GO annotations related to this gene include kinesin binding.

UniProtKB/Swiss-Prot for KIFAP3 Gene

  • Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex (By similarity).

Gene Wiki entry for KIFAP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIFAP3 Gene

Genomics for KIFAP3 Gene

Regulatory Elements for KIFAP3 Gene

Genomic Location for KIFAP3 Gene

Start:
169,921,326 bp from pter
End:
170,085,208 bp from pter
Size:
163,883 bases
Orientation:
Minus strand

Genomic View for KIFAP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIFAP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIFAP3 Gene

Proteins for KIFAP3 Gene

  • Protein details for KIFAP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92845-KIFA3_HUMAN
    Recommended name:
    Kinesin-associated protein 3
    Protein Accession:
    Q92845
    Secondary Accessions:
    • B1AKU4
    • B1AKU5
    • B2RDL1
    • B7Z8A3
    • F5H591
    • Q8NHU7
    • Q9H416

    Protein attributes for KIFAP3 Gene

    Size:
    792 amino acids
    Molecular mass:
    91205 Da
    Quaternary structure:
    • Heterotrimer of KIFAP3, KIF3A and KIF3B. Interacts with RAP1GDS1/SMG GDS. Interacts with SMC3 subunit of the cohesin complex.

    Alternative splice isoforms for KIFAP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIFAP3 Gene

Proteomics data for KIFAP3 Gene at MOPED

Post-translational modifications for KIFAP3 Gene

  • Phosphorylated on tyrosine residues by SRC in vitro; this reduces the binding affinity of the protein for RAP1GDS1.
  • Ubiquitination at Lys59, Lys469, Lys477, and Lys485
  • Modification sites at PhosphoSitePlus

Other Protein References for KIFAP3 Gene

No data available for DME Specific Peptides for KIFAP3 Gene

Domains for KIFAP3 Gene

Protein Domains for KIFAP3 Gene

Graphical View of Domain Structure for InterPro Entry

Q92845

UniProtKB/Swiss-Prot:

KIFA3_HUMAN :
  • Q92845
Similarity:
  • Contains 5 ARM repeats.
genes like me logo Genes that share domains with KIFAP3: view

No data available for Gene Families for KIFAP3 Gene

Function for KIFAP3 Gene

Molecular function for KIFAP3 Gene

UniProtKB/Swiss-Prot Function: Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex (By similarity).

Gene Ontology (GO) - Molecular Function for KIFAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 16298999
GO:0019894 kinesin binding IPI 16298999
genes like me logo Genes that share ontologies with KIFAP3: view
genes like me logo Genes that share phenotypes with KIFAP3: view

Animal Models for KIFAP3 Gene

MGI Knock Outs for KIFAP3:

miRNA for KIFAP3 Gene

miRTarBase miRNAs that target KIFAP3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for KIFAP3 Gene

Localization for KIFAP3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIFAP3 Gene COMPARTMENTS Subcellular localization image for KIFAP3 gene
Compartment Confidence
cytoskeleton 4
cytosol 4
endoplasmic reticulum 4
nucleus 4
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KIFAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000794 condensed nuclear chromosome IDA 16298999
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005813 centrosome IDA 16298999
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with KIFAP3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KIFAP3 Gene

Pathways for KIFAP3 Gene

genes like me logo Genes that share pathways with KIFAP3: view

Gene Ontology (GO) - Biological Process for KIFAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006461 protein complex assembly TAS 8900189
GO:0006996 organelle organization TAS --
GO:0007017 microtubule-based process ISS --
GO:0007018 microtubule-based movement TAS --
GO:0007165 signal transduction TAS 8900189
genes like me logo Genes that share ontologies with KIFAP3: view

Compounds for KIFAP3 Gene

(4) Novoseek inferred chemical compound relationships for KIFAP3 Gene

Compound -log(P) Hits PubMed IDs
gdp 82.3 12
gtp 71.8 11
nadph 24 4
tyrosine 0 4
genes like me logo Genes that share compounds with KIFAP3: view

Transcripts for KIFAP3 Gene

Unigene Clusters for KIFAP3 Gene

Kinesin-associated protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIFAP3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
SP1: -
SP2:
SP3: -
SP4:

Relevant External Links for KIFAP3 Gene

GeneLoc Exon Structure for
KIFAP3
ECgene alternative splicing isoforms for
KIFAP3

Expression for KIFAP3 Gene

mRNA expression in normal human tissues for KIFAP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIFAP3 Gene

SOURCE GeneReport for Unigene cluster for KIFAP3 Gene Hs.433442

genes like me logo Genes that share expressions with KIFAP3: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KIFAP3 Gene

Orthologs for KIFAP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for KIFAP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIFAP3 35
  • 99.62 (n)
  • 100 (a)
KIFAP3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIFAP3 35
  • 94.7 (n)
  • 98.48 (a)
KIFAP3 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIFAP3 35
  • 94.87 (n)
  • 98.73 (a)
KIFAP3 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kifap3 35
  • 89.23 (n)
  • 98.15 (a)
Kifap3 16
Kifap3 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIFAP3 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIFAP3 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kifap3 35
  • 89.08 (n)
  • 98.3 (a)
chicken
(Gallus gallus)
Aves KIFAP3 35
  • 82.76 (n)
  • 94.62 (a)
KIFAP3 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIFAP3 36
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3217 35
tropical clawed frog
(Silurana tropicalis)
Amphibia kifap3 35
  • 79.08 (n)
  • 89.19 (a)
Str.19013 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4647 35
zebrafish
(Danio rerio)
Actinopterygii kifap3a 35
  • 73.23 (n)
  • 80.81 (a)
kifap3a 36
  • 81 (a)
OneToMany
kifap3b 36
  • 78 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000187 35
  • 55.62 (n)
  • 54.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta Kap3 35
  • 54.04 (n)
  • 49.54 (a)
Kap3 36
  • 36 (a)
OneToOne
Kap 37
  • 46 (a)
worm
(Caenorhabditis elegans)
Secernentea kap-1 35
  • 51.11 (n)
  • 39.57 (a)
kap-1 36
  • 37 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5167 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2089 36
  • 59 (a)
OneToOne
Species with no ortholog for KIFAP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIFAP3 Gene

ENSEMBL:
Gene Tree for KIFAP3 (if available)
TreeFam:
Gene Tree for KIFAP3 (if available)

Paralogs for KIFAP3 Gene

No data available for Paralogs for KIFAP3 Gene

Variants for KIFAP3 Gene

Sequence variations from dbSNP and Humsavar for KIFAP3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs4519 -- 169,921,433(+) TTTTG(A/T)GGCTC utr-variant-3-prime
rs7674 -- 169,921,482(+) AGTGA(A/G)CAATG utr-variant-3-prime
rs476269 -- 169,974,145(+) GGGAT(A/G)TATAA intron-variant
rs476485 -- 169,955,687(+) TTAAT(G/T)ACATA intron-variant
rs478116 -- 169,935,384(+) CCTTT(C/T)TAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIFAP3 Gene

Variant ID Type Subtype PubMed ID
esv2430109 CNV Deletion 19546169
nsv433500 CNV Loss 18776910
esv271754 CNV Insertion 20981092

Relevant External Links for KIFAP3 Gene

HapMap Linkage Disequilibrium report
KIFAP3
Human Gene Mutation Database (HGMD)
KIFAP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIFAP3 Gene

Disorders for KIFAP3 Gene

(1) University of Copenhagen DISEASES for KIFAP3 Gene

Relevant External Links for KIFAP3

Genetic Association Database (GAD)
KIFAP3
Human Genome Epidemiology (HuGE) Navigator
KIFAP3
genes like me logo Genes that share disorders with KIFAP3: view

No data available for UniProtKB/Swiss-Prot for KIFAP3 Gene

Publications for KIFAP3 Gene

  1. SMAP, an Smg GDS-associating protein having arm repeats and phosphorylated by src tyrosine kinase. (PMID: 8900189) Shimizu K. … Takai Y. (J. Biol. Chem. 1996) 2 3 4 23
  2. Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide. (PMID: 9506951) Shimizu K. … Takai Y. (J. Biol. Chem. 1998) 3 4 23
  3. Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. (PMID: 19451621) Landers J.E. … Brown R.H. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 23 48
  4. Kinesin-2 is a motor for late endosomes and lysosomes. (PMID: 16262723) Brown C.L. … Schroer T.A. (Traffic 2005) 3 23
  5. Role of the kinesin-2 family protein, KIF3, during mitosis. (PMID: 16298999) Haraguchi K. … Akiyama T. (J. Biol. Chem. 2006) 3 23

Products for KIFAP3 Gene

Sources for KIFAP3 Gene

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