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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KIF9 Gene

protein-coding   GIFtS: 49
GCID: GC03M047269

kinesin family member 9

  Search for KIF9
in our new
 Human Malady Compendium 
Biological research products
for KIF9
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Kinesin Family Member 91 2
MGC1041861
Kinesin Protein 92
Kinesin-Like Protein KIF92

External Ids:    HGNC: 166661   Entrez Gene: 641472   Ensembl: ENSG000000887277   OMIM: 6079105   UniProtKB: Q9HAQ23   

Export aliases for KIF9 gene to outside databases

Previous GC identifers: GC03M047058 GC03M046480 GC03M047230 GC03M047222 GC03M047244


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KIF9 gene promoter:
         GATA-3   Pax-5   AML1a   LCR-F1   Tal-1beta   Ik-3   Evi-1   c-Ets-1   AREB6   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKIF9 promoter sequence
   Search SABiosciences Chromatin IP Primers for KIF9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIF9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.31

KIF9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIF9 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M047269:  view genomic region     (about GC identifiers)

Start:
47,269,516 bp from pter      End:
47,324,941 bp from pter
Size:
55,426 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KIF9_HUMAN, Q9HAQ2 (See protein sequence)
Recommended Name: Kinesin-like protein KIF9  
Size: 790 amino acids; 89986 Da
Subcellular location: Cytoplasm, cytoskeleton (Probable)
Sequence caution: Sequence=BAB14713.1; Type=Miscellaneous discrepancy; Note=Dubious isoform. Probable cloning artifact
lacking polyadenylation evidence;
1 PDB 3D structure from and Proteopedia for KIF9:
3NWN (3D)    
Secondary accessions: Q86Z28 Q9H8A4
Alternative splicing: 2 isoforms:  Q9HAQ2-1   Q9HAQ2-2   

Explore the universe of human proteins at neXtProt for KIF9: NX_Q9HAQ2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9HAQ2

  • KIF9 Protein expression data from MOPED and PaxDb:    About this image 
    KIF9 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001128350.1  NP_071737.1  NP_878905.2  

    ENSEMBL proteins: 
     ENSP00000265529   ENSP00000414987   ENSP00000391100   ENSP00000405774   ENSP00000387959  
     ENSP00000406815   ENSP00000391099   ENSP00000406603   ENSP00000333942   ENSP00000292334  
    Reactome Protein details: Q9HAQ2
    Human Recombinant Protein Products for KIF9: 
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    Novus Biologicals KIF9 Protein
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    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for KIF9

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005874microtubule IEA--
    GO:0005875microtubule associated complex IEA--

    KIF9 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    KIF9 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001752 Kinesin_motor_dom
     IPR019821 Kinesin_motor_CS

    Graphical View of Domain Structure for InterPro Entry Q9HAQ2

    ProtoNet protein and cluster: Q9HAQ2

    1 Blocks protein family: IPB001752 Kinesin

    UniProtKB/Swiss-Prot: KIF9_HUMAN, Q9HAQ2
    Similarity: Belongs to the kinesin-like protein family
    Similarity: Contains 1 kinesin-motor domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003777microtubule motor activity IEA--
    GO:0005524ATP binding IEA--
         
    KIF9 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for KIF9 

    miRNA
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    hsa-miR-765 hsa-miR-1324 hsa-miR-1285 hsa-miR-646 hsa-miR-612 hsa-miR-149 hsa-miR-2117 hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidKIF9 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF9


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Kinesins
    Kinesins1.00
    2Factors involved in megakaryocyte development and platelet production
    Factors involved in megakaryocyte development and platelet production1.00
    3Platelet activation, signaling and aggregation
    Hemostasis0.43

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for KIF9
        Hemostasis
    Factors involved in megakaryocyte development and platelet production
    Kinesins



    KIF9 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIF9

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for KIF9 (ENSP000002655294) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KIF26AENSP000003882414STRING: ENSP00000388241
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007018microtubule-based movement TAS--
    GO:0007596blood coagulation TAS--

    KIF9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KIF9
    Search CenterWatch for drugs/clinical trials and news about KIF9 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KIF9 gene (4 alternative transcripts): 
    NM_182903.2  NM_001134878.1  NM_022342.4  NM_182902.3  

    Unigene Cluster for KIF9:

    Kinesin family member 9
    Hs.373947  [show with all ESTs]
    Unigene Representative Sequence: NM_001134878
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265529 ENST00000444589(uc011bat.1) ENST00000452770 ENST00000487440(uc011bau.1)
    ENST00000443784 ENST00000489391 ENST00000484629 ENST00000456548 ENST00000425853
    ENST00000432493(uc003cra.4) ENST00000425452 ENST00000498584 ENST00000335044(uc010hjp.3 uc003cqx.3 uc003cqy.3)
    ENST00000352910

    miRNA
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    hsa-miR-765 hsa-miR-1324 hsa-miR-1285 hsa-miR-646 hsa-miR-612 hsa-miR-149 hsa-miR-2117 hsa-miR-24
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    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIF9

    Additional cDNA sequence: 

    AF311212.1 AK023894.1 AK292547.1 AK302070.1 AK314418.1 BC015311.2 BC030657.2 BC104479.1 

    14 DOTS entries:

    DT.108876  DT.205922  DT.100033585  DT.120913236  DT.100816021  DT.100816022  DT.100816023  DT.406291 
    DT.70100901  DT.40227450  DT.86847339  DT.95208661  DT.95321736  DT.99995811 

    24/117 AceView cDNA sequences (see all 117):

    AA601194 AA912766 NM_182902 BC030657 AU141483 AI655206 BF589218 BM559620 
    AL040251 NM_182903 AI638287 BF108784 AK023894 BM716877 AI741745 AF311212 
    AI394157 AI253142 AA757997 BE048228 AI762451 F09639 BG772296 AI380275 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for KIF9 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^
    SP1:                                      -     -     -           -                 -     -     -     -                             -                       -   
    SP2:                                      -     -     -           -                 -     -     -     -                             -                       -   
    SP3:                                      -     -     -           -                 -     -     -     -                             -                       -   
    SP4:                                                                                -     -     -     -     -                                                   
    SP5:                                                  -           -                                                                                             

    ExUns: 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25
    SP1:                                                  -                           
    SP2:                                      -           -                           
    SP3:                                                                              
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for KIF9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KIF9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAATGATCAG
    KIF9 Expression
    About this image

    KIF9 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See KIF9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KIF9

    SOURCE GeneReport for Unigene cluster: Hs.373947
        SABiosciences Custom PCR Arrays for KIF9
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KIF9 gene from 6/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves KIF91 kinesin family member 9 65.94(n)
    62.45(a)
      420405  XM_418511.3  XP_418511.3 
    lizard
    (Anolis carolinensis)
    Reptilia KIF96
    --
    58(a)
    1 ↔ 1
    GL343865.1(145967-171056)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.158062 Xenopus laevis transcribed sequence with moderate similarity more 76.74(n)    BJ031630.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5534381 kinesin family member 9-like 56.73(n)
    50.7(a)
      553438  XM_001922425.2  XP_001922460.1 
    honey bee
    (Apis mellifera)
    Insecta --
    --
    12(a)
    possible ortholog
    Group15.8(1309414-1312762)
    worm
    (Caenorhabditis elegans)
    Secernentea klp-176
    klp-166
    (see all 3)
    Kinesin-Like Protein family member (klp-16)
    (see all 3)
    18(a)
    17(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    II(11465875-11467577)
    I(9512444-9514747)


    ENSEMBL Gene Tree for KIF9 (if available)
    TreeFam Gene Tree for KIF9 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KIF9 gene
    KIF5C2  KIF21A2  KIF112  KIF3B2  KIF21B2  KIF172  KIF4B2  KIF272  
    KIF3A2  KIF4A2  KIF5B2  KIF62  KIF152  CENPE2  KIF5A2  KIF72  
    KIF3C2  
    16 SIMAP similar genes for KIF9 using alignment to 6 protein entries:     KIF9_HUMAN (see all proteins):
    KIF5A    KIF5C    KIF5B    KIF6    KIF13A    KIF18B
    KIF27    KIF3A    KIF22    KIFC3    KIF13B    KLP6
    KIF1A    KIF3C    KIF21A    CENPE

    KIF9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/718 NCBI SNPs in KIF9 are shown (see all 718    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1931676851,2
    --47269127(+) ACTGAA/TACTTT 4 -- int1 ds50010--------
    rs76431501,2
    C,F,A,H--47269135(+) TTTTCA/GCTCAG 4 -- ds5001 int118Minor allele frequency- G:0.05NA NS WA CSA EA 639
    rs76432391,2
    C,F,H--47269169(+) GGGGCG/ATATCA 4 -- ds5001 int14Minor allele frequency- A:0.01NS EA 418
    rs1485315601,2
    --47269293(+) GAGTGA/GTATCT 4 -- ds5001 int10--------
    rs1846770511,2
    --47269390(+) CACGGA/GGAGAG 4 -- ds5001 int10--------
    rs1510304531,2
    --47269496(+) CAGAAC/GCTGCT 4 -- ds5001 int10--------
    rs1400035171,2
    --47269553(+) GGTCTC/TTGTGG 4 -- int1 ut310--------
    rs764451791,2
    C,F--47269661(+) AGGGTC/TTGAGG 4 -- ut31 int11Minor allele frequency- T:0.09WA 118
    rs1448862121,2
    --47269710(+) ACCCCC/TACCCT 4 -- ut31 int10--------
    rs1899497851,2
    --47269857(+) ACAGGA/GAATAA 4 -- ut31 int10--------

    HapMap Linkage Disequilibrium report for KIF9 (47269516 - 47324941 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for KIF9: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    KIF9 for disorders           About MalaCards

    KIF9 for disorders           About GeneDecksing

    OMIM gene information: 607910    OMIM disorders: --


    Export disorders for KIF9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KIF9 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with KIF9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The Ras-like GTPase Gem is involved in cell shape remodelling and interacts with the novel kinesin-like protein KIF9. (PubMed id 11483511)1, 3 Piddini E....Dotti C.G. (2001)
    4. The kinesin KIF9 and reggie/flotillin proteins regula te matrix degradation by macrophage podosomes. (PubMed id 21119006)1 Cornfine S....Linder S. (2011)
    5. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    6. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
    9. Kinesin 9 family members perform separate functions i n the trypanosome flagellum. (PubMed id 19948486)9 Demonchy R....Kohl L. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64147 HGNC: 16666 AceView: KIF9 Ensembl:ENSG00000088727 euGenes: HUgn64147
    ECgene: KIF9 H-InvDB: KIF9

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KIF9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KIF9 gene:
    Search GeneIP for patents involving KIF9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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