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Aliases for KIF9 Gene

Aliases for KIF9 Gene

  • Kinesin Family Member 9 2 3 5

External Ids for KIF9 Gene

Previous GeneCards Identifiers for KIF9 Gene

  • GC03M047058
  • GC03M046480
  • GC03M047230
  • GC03M047222
  • GC03M047244

Summaries for KIF9 Gene

GeneCards Summary for KIF9 Gene

KIF9 (Kinesin Family Member 9) is a Protein Coding gene. Among its related pathways are Golgi-to-ER retrograde transport and Vesicle-mediated transport. GO annotations related to this gene include ATPase activity and microtubule binding. An important paralog of this gene is KIF6.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF9 Gene

Genomics for KIF9 Gene

Regulatory Elements for KIF9 Gene

Enhancers for KIF9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G047008 1.3 Ensembl ENCODE dbSUPER 10.6 +273.7 273718 2.3 HDGF PKNOX1 SIN3A RAD21 ETS1 GLIS2 ZNF207 EGR2 SP3 GATAD2B NBEAL2 CCDC12 KIF9 KLHL18 NRADDP
GH03G047346 1.2 Ensembl ENCODE 11.4 -64.1 -64066 1.0 PKNOX1 CREB3L1 ARNT YBX1 TCF12 ZNF121 ZNF766 ELK1 GATA2 ZNF143 NBEAL2 KIF9 KLHL18 SETD2 KIF9-AS1 CCDC12 SCAP ENSG00000280173 PTPN23
GH03G047314 1.2 Ensembl ENCODE 11.2 -31.7 -31667 1.4 ATF1 CREB3L1 ARNT TCF12 ZNF766 ELK1 GATA2 NCOA1 REST ZNF592 KLHL18 KIF9 SETD2 KIF9-AS1 PTH1R MYL3 GC03P047316
GH03G047140 1.1 Ensembl ENCODE 11 +142.0 141951 1.8 HDGF TBP FOXA2 EGR1 IKZF2 CEBPB TBX21 PRDM6 CEBPA IKZF1 NBEAL2 SETD2 KIF9-AS1 KIF9 KLHL18 PTPN23 MRPL57P3
GH03G047112 1 Ensembl ENCODE 10.5 +169.0 169033 3.1 PKNOX1 MTA2 ARNT BHLHE40 CEBPG DPF2 TBX21 JUND SCRT2 IKZF1 SETD2 KIF9-AS1 NBEAL2 KIF9 KLHL18 MRPL57P3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KIF9 on UCSC Golden Path with GeneCards custom track

Promoters for KIF9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000151986 751 2201 MLX CREB3L1 AGO1 YBX1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3

Genomic Location for KIF9 Gene

Chromosome:
3
Start:
47,228,026 bp from pter
End:
47,283,451 bp from pter
Size:
55,426 bases
Orientation:
Minus strand

Genomic View for KIF9 Gene

Genes around KIF9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF9 Gene

Proteins for KIF9 Gene

  • Protein details for KIF9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAQ2-KIF9_HUMAN
    Recommended name:
    Kinesin-like protein KIF9
    Protein Accession:
    Q9HAQ2
    Secondary Accessions:
    • Q86Z28
    • Q9H8A4

    Protein attributes for KIF9 Gene

    Size:
    790 amino acids
    Molecular mass:
    89986 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14713.1; Type=Miscellaneous discrepancy; Note=Dubious isoform. Probable cloning artifact lacking polyadenylation evidence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KIF9 Gene

    Alternative splice isoforms for KIF9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF9 Gene

Post-translational modifications for KIF9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KIF9 Gene

Domains & Families for KIF9 Gene

Gene Families for KIF9 Gene

Protein Domains for KIF9 Gene

Suggested Antigen Peptide Sequences for KIF9 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HAQ2

UniProtKB/Swiss-Prot:

KIF9_HUMAN :
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIF9: view

Function for KIF9 Gene

Gene Ontology (GO) - Molecular Function for KIF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0003777 microtubule motor activity IBA --
GO:0005515 protein binding IPI 21119006
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
genes like me logo Genes that share ontologies with KIF9: view
genes like me logo Genes that share phenotypes with KIF9: view

Animal Model Products

  • Taconic Biosciences Mouse Models for KIF9

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KIF9 Gene

Localization for KIF9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF9 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIF9 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 3

Gene Ontology (GO) - Cellular Components for KIF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002102 podosome IDA 21119006
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005871 kinesin complex IBA --
GO:0005874 microtubule IEA,IDA 21119006
genes like me logo Genes that share ontologies with KIF9: view

Pathways & Interactions for KIF9 Gene

genes like me logo Genes that share pathways with KIF9: view

Gene Ontology (GO) - Biological Process for KIF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007018 microtubule-based movement IBA --
GO:0022617 extracellular matrix disassembly IMP 21119006
GO:0071801 regulation of podosome assembly IMP 21119006
GO:1903008 organelle disassembly IMP 21119006
genes like me logo Genes that share ontologies with KIF9: view

No data available for SIGNOR curated interactions for KIF9 Gene

Drugs & Compounds for KIF9 Gene

No Compound Related Data Available

Transcripts for KIF9 Gene

Unigene Clusters for KIF9 Gene

Kinesin family member 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF9 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - -
SP5: - -
SP6: -
SP7: - - - -
SP8: - - - -
SP9: - -
SP10:
SP11: - - -

ExUns: 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25
SP1: -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for KIF9 Gene

GeneLoc Exon Structure for
KIF9
ECgene alternative splicing isoforms for
KIF9

Expression for KIF9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIF9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIF9 Gene

This gene is overexpressed in Testis (x9.3).

Protein differential expression in normal tissues from HIPED for KIF9 Gene

This gene is overexpressed in Urine (20.4), Frontal cortex (16.0), Platelet (15.9), Testis (9.4), and Blymphocyte (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KIF9 Gene



Protein tissue co-expression partners for KIF9 Gene

NURSA nuclear receptor signaling pathways regulating expression of KIF9 Gene:

KIF9

SOURCE GeneReport for Unigene cluster for KIF9 Gene:

Hs.373947

Evidence on tissue expression from TISSUES for KIF9 Gene

  • Thyroid gland(4.2)
genes like me logo Genes that share expression patterns with KIF9: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIF9 Gene

Orthologs for KIF9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIF9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF9 34 35
  • 96.86 (n)
dog
(Canis familiaris)
Mammalia KIF9 34 35
  • 90.49 (n)
cow
(Bos Taurus)
Mammalia KIF9 34 35
  • 90.07 (n)
rat
(Rattus norvegicus)
Mammalia Kif9 34
  • 88.06 (n)
mouse
(Mus musculus)
Mammalia Kif9 34 16 35
  • 87.05 (n)
oppossum
(Monodelphis domestica)
Mammalia KIF9 35
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 35 (a)
ManyToMany
-- 35
  • 14 (a)
ManyToMany
chicken
(Gallus gallus)
Aves KIF9 34 35
  • 64.91 (n)
lizard
(Anolis carolinensis)
Reptilia KIF9 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492300 34
  • 66.3 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15806 34
zebrafish
(Danio rerio)
Actinopterygii LOC553438 34
  • 56.76 (n)
KIF9 35
  • 40 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 48 (a)
OneToOne
Species where no ortholog for KIF9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIF9 Gene

ENSEMBL:
Gene Tree for KIF9 (if available)
TreeFam:
Gene Tree for KIF9 (if available)

Paralogs for KIF9 Gene

Variants for KIF9 Gene

Sequence variations from dbSNP and Humsavar for KIF9 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000016139 -- 47,255,546(+) ACTGG(A/G)GAGGG intron-variant
rs1000098136 -- 47,264,491(+) TAGTG(C/T)AGTGA intron-variant, upstream-variant-2KB
rs1000106868 -- 47,260,376(+) CTGAA(C/T)GCTGG intron-variant
rs1000114736 -- 47,238,650(+) TTTAA(C/T)ACTGA intron-variant
rs1000258294 -- 47,258,211(+) GATAT(A/C)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF9 Gene

Variant ID Type Subtype PubMed ID
nsv1007714 CNV gain 25217958
nsv428417 CNV loss 18775914

Variation tolerance for KIF9 Gene

Residual Variation Intolerance Score: 81.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.00; 49.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIF9 Gene

Human Gene Mutation Database (HGMD)
KIF9
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIF9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF9 Gene

Disorders for KIF9 Gene

Relevant External Links for KIF9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIF9

No disorders were found for KIF9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIF9 Gene

Publications for KIF9 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The Ras-like GTPase Gem is involved in cell shape remodelling and interacts with the novel kinesin-like protein KIF9. (PMID: 11483511) Piddini E. … Dotti C.G. (EMBO J. 2001) 2 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3 64

Products for KIF9 Gene

Sources for KIF9 Gene

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