KIF6 Gene
protein-coding GIFtS: 53
GCID: GC06M039297
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kinesin family member 6(Previous name: chromosome 6 open reading frame 102 )
(Previous symbol: C6orf102)
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Aliases
for KIF6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Kinesin Family Member 61 2 | | DKFZp451I24181 | | C6orf1021 2 3 | | MGC333171 | | DJ1043E3.11 | | Chromosome 6 Open Reading Frame 1021 | | DJ137F1.41 | | Kinesin-Like Protein KIF62 | | DJ188D3.11 | | |
Export aliases for KIF6 gene to outside databasesPrevious GC identifers: GC00U914198 GC06U900645 GC06M039412 GC06M039021 |
Summaries
for KIF6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for KIF6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KIF6 gene promoter:
RP58 AML1a ATF-2 Pax-2 Pax-2a HNF-1A S8 Pax-2b HNF-1 Hlf
Other transcription factors
Search SABiosciences Chromatin IP Primers for KIF6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIF6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.2 Ensembl cytogenetic band: 6p21.2 HGNC cytogenetic band: 6p21.2KIF6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M039297: view genomic region
(about GC identifiers)
Start:
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39,297,766 bp from pter |
End:
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39,693,181 bp from pter |
Size:
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395,416 bases |
Orientation:
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minus strand |
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Proteins
for KIF6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KIF6_HUMAN, Q6ZMV9 (See
protein sequence)Recommended Name: Kinesin-like protein KIF6 Size: 814 amino acids; 92569 Da
Subcellular location: Cytoplasm, cytoskeleton (Probable)
Secondary accessions: Q2MDE3 Q2MDE4 Q5T8J6 Q6ZWE3 Q86T87 Q8WTV4Alternative splicing: 4 isoforms: Q6ZMV9-1 Q6ZMV9-2 Q6ZMV9-3 Q6ZMV9-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for KIF6: NX_Q6ZMV9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6ZMV9
KIF6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_659464.3
ENSEMBL proteins: ENSP00000287152 ENSP00000409417 ENSP00000377889 ENSP00000229913 ENSP00000404856 ENSP00000362312 ENSP00000362311 ENSP00000441435 ENSP00000362309 ENSP00000439064
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
KIF6 for ontologies About GeneDecksing
KIF6 Antibody Products:
Assay Products for KIF6: |
Protein
Domains /
Families
for KIF6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KIF6 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6ZMV9ProtoNet protein and cluster: Q6ZMV9 1 Blocks protein family: IPB001752 Kinesin
UniProtKB/Swiss-Prot: KIF6_HUMAN, Q6ZMV9Similarity: Belongs to the kinesin-like protein familySimilarity: Contains 1 kinesin-motor domain |
Function
for KIF6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIF6 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIF6 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: KIF6 (NM_145027) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KIF6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIF6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF6 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
KIF6 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for KIF6:
|
Pathways & Interactions
for KIF6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIF6
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for KIF6 (Q6ZMV91, 2, 3 ENSP000002871524) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0007018 | microtubule-based movement |
IEA | -- |
KIF6 for ontologies About GeneDecksing
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Drugs & Compounds
for KIF6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
KIF6 for compounds About GeneDecksing
 Browse Tocris compounds for KIF6
1 PharmGKB related drug/compound annotation for KIF6 geneAbout this table
Search CenterWatch for drugs/clinical trials and news about KIF6
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Transcripts
for KIF6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KIF6 gene: NM_145027.4 Unigene Cluster for KIF6: Kinesin family member 6 Hs.588202 [show with all ESTs]Unigene Representative Sequence: NM_14502712 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000287152(uc003oot.2 uc011dua.1 uc010jxb.1) ENST00000458470
ENST00000394362(uc003oos.2) ENST00000229913 ENST00000441975 ENST00000482238
ENST00000465719(uc003oou.3) ENST00000373216(uc010jxa.1) ENST00000373215
ENST00000538893 ENST00000373213(uc010jwz.1) ENST00000541946
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIF6 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIF6 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KIF6 (NM_145027) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KIF6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIF6 |
Additional cDNA sequence: AK131471.1 BC022074.2 BC043552.1 BC098418.1 BC117307.1 BC143444.1 BC143445.1 BX649045.1 11 DOTS entries: DT.99930082 DT.97822241 DT.91679693 DT.101960199 DT.40244026 DT.40287381 DT.95187832 DT.429768 DT.100666855 DT.40307652 DT.75191915 24/39 AceView cDNA sequences (see all 39): BX114379 AI352520 BX649045 BE858267 AI168595 BX111141 BE223014 BX106415 BC022074 AL041547 BF057276 BC043552 AI693047 AK097521 NM_145027 BX499296 AI222076 AK123217 AK131471 BM696570 AA705330 BG199894 AI026880 BI118088
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for KIF6 (see all 7) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | · | 16c | · | 16d | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21a | · |
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| SP1: | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 21b | ^ | 22a | · | 22b | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26a | · | 26b |
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| SP1: | | | | | | | | | | | - | | | | | | |
| SP2: | | | - | | - | | | | | | - | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | | |
ECgene alternative splicing isoforms for KIF6
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Expression
for KIF6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KIF6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACGGTCCCA
About this image
See KIF6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KIF6
SOURCE GeneReport for Unigene cluster: Hs.588202
SABiosciences Custom PCR Arrays for KIF6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIF6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KIF6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIF6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIF6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF6 |
Orthologs
for KIF6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for KIF6 gene from 5/20 species (see all 20) About this table
ENSEMBL Gene Tree for KIF6 (if available)
TreeFam Gene Tree for KIF6 (if available) |
Paralogs
for KIF6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KIF6 gene
- KIF5C2 KIF21A2 KIF112 KIF3B2 KIF21B2 KIF92 KIF172 KIF4B2
- KIF272 KIF5B2 KIF3A2 KIF4A2 CENPE2 KIF152 KIF5A2 KIF72
- KIF3C2
18/31 SIMAP similar genes for KIF6 using alignment to 11 protein entries: KIF6_HUMAN (see all proteins)
(see all similar genes):KIFC3 KIF13A KIF18A KIF18B KIF17 KIF5B-ALK
KLP6 KIF9 KIF15 KIF5C KIF1A KIF1Bbeta
KIF5B KIF13B KIF19 KIF3A KIF22 KIF27
KIF6 for paralogs About GeneDecksing
|
Genomic Variants
for KIF6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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