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Aliases for KIF6 Gene

Aliases for KIF6 Gene

  • Kinesin Family Member 6 2 3
  • C6orf102 3 4
  • Chromosome 6 Open Reading Frame 102 2
  • DJ1043E3.1 3
  • DJ137F1.4 3
  • DJ188D3.1 3

External Ids for KIF6 Gene

Previous HGNC Symbols for KIF6 Gene

  • C6orf102

Previous GeneCards Identifiers for KIF6 Gene

  • GC00U914198
  • GC06U900645
  • GC06M039412
  • GC06M039297
  • GC06M039021
  • GC06M039330

Summaries for KIF6 Gene

GeneCards Summary for KIF6 Gene

KIF6 (Kinesin Family Member 6) is a Protein Coding gene. Diseases associated with KIF6 include smallpox. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF9.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF6 Gene

Genomics for KIF6 Gene

Regulatory Elements for KIF6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KIF6 Gene

39,329,990 bp from pter
39,725,472 bp from pter
395,483 bases
Minus strand

Genomic View for KIF6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF6 Gene

Proteins for KIF6 Gene

  • Protein details for KIF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kinesin-like protein KIF6
    Protein Accession:
    Secondary Accessions:
    • Q2MDE3
    • Q2MDE4
    • Q5T8J6
    • Q6ZWE3
    • Q86T87
    • Q8WTV4

    Protein attributes for KIF6 Gene

    814 amino acids
    Molecular mass:
    92569 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KIF6 Gene


neXtProt entry for KIF6 Gene

Proteomics data for KIF6 Gene at MOPED

Post-translational modifications for KIF6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KIF6 Gene

Domains & Families for KIF6 Gene

Gene Families for KIF6 Gene

Protein Domains for KIF6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 kinesin motor domain.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
  • Contains 1 kinesin motor domain.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIF6: view

Function for KIF6 Gene

Gene Ontology (GO) - Molecular Function for KIF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity IBA --
GO:0005515 protein binding IPI 16189514
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
GO:0016887 ATPase activity IBA --
genes like me logo Genes that share ontologies with KIF6: view
genes like me logo Genes that share phenotypes with KIF6: view

Animal Model Products

miRNA for KIF6 Gene

miRTarBase miRNAs that target KIF6

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for KIF6 Gene

Localization for KIF6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF6 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Jensen Localization Image for KIF6 Gene COMPARTMENTS Subcellular localization image for KIF6 gene
Compartment Confidence
cytoskeleton 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for KIF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001673 male germ cell nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005871 kinesin complex IBA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with KIF6: view

Pathways & Interactions for KIF6 Gene

SuperPathways for KIF6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KIF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007018 microtubule-based movement IBA --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with KIF6: view

No data available for Pathways by source and SIGNOR curated interactions for KIF6 Gene

Drugs & Compounds for KIF6 Gene

(2) Drugs for KIF6 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Atorvastatin Approved Pharma Competitive, Inhibitor 690
Pravastatin Approved Pharma 142
genes like me logo Genes that share compounds with KIF6: view

Transcripts for KIF6 Gene

Unigene Clusters for KIF6 Gene

Kinesin family member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIF6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c · 16d ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
SP1: - - - - -
SP2: - - -
SP3: - - - -

ExUns: 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26a · 26b
SP1: -
SP2: - - -
SP3: -
SP5: -
SP6: - - -

Relevant External Links for KIF6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KIF6 Gene

mRNA expression in normal human tissues for KIF6 Gene

mRNA differential expression in normal tissues according to GTEx for KIF6 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.9), Brain - Substantia nigra (x5.2), and Brain - Hippocampus (x4.2).

Protein differential expression in normal tissues from HIPED for KIF6 Gene

This gene is overexpressed in Fetal heart (37.0) and Heart (25.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIF6 Gene

SOURCE GeneReport for Unigene cluster for KIF6 Gene Hs.588202

genes like me logo Genes that share expression patterns with KIF6: view

Protein tissue co-expression partners for KIF6 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for KIF6 Gene

Orthologs for KIF6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIF6 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia KIF6 35
  • 86.75 (n)
  • 86.34 (a)
KIF6 36
  • 87 (a)
(Mus musculus)
Mammalia Kif6 35
  • 81.59 (n)
  • 83.42 (a)
Kif6 16
Kif6 36
  • 79 (a)
(Pan troglodytes)
Mammalia KIF6 35
  • 98.89 (n)
  • 98.4 (a)
KIF6 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Kif6 35
  • 80.67 (n)
  • 83.29 (a)
(Bos Taurus)
Mammalia KIF6 36
  • 80 (a)
(Monodelphis domestica)
Mammalia KIF6 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia KIF6 36
  • 79 (a)
(Gallus gallus)
Aves KIF6 35
  • 69.56 (n)
  • 68.84 (a)
KIF6 36
  • 61 (a)
(Anolis carolinensis)
Reptilia KIF6 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kif6 35
  • 66.62 (n)
  • 69.88 (a)
(Danio rerio)
Actinopterygii kif6 35
  • 61.6 (n)
  • 61.65 (a)
kif6 36
  • 55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
Species with no ortholog for KIF6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIF6 Gene

Gene Tree for KIF6 (if available)
Gene Tree for KIF6 (if available)

Paralogs for KIF6 Gene

Paralogs for KIF6 Gene

genes like me logo Genes that share paralogs with KIF6: view

Variants for KIF6 Gene

Sequence variations from dbSNP and Humsavar for KIF6 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1520 -- 39,559,091(+) CATCT(A/G)TAGTG intron-variant
rs20455 - 39,357,302(-) ATGAA(C/T)GGTCC missense, reference
rs20456 -- 39,357,147(-) TTTAC(C/T)GTTTA intron-variant
rs20457 -- 39,357,090(-) GCACA(C/T)CCCTT intron-variant
rs149242 -- 39,723,717(+) gggag(G/T)ggaac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF6 Gene

Variant ID Type Subtype PubMed ID
nsv830644 CNV Loss 17160897
nsv830645 CNV Loss 17160897
nsv885822 CNV Loss 21882294
esv2731955 CNV Deletion 23290073
esv2521582 CNV Insertion 19546169
esv271295 CNV Insertion 20981092
nsv428145 CNV Gain 18775914
nsv885823 CNV Loss 21882294
nsv5271 CNV Insertion 18451855
nsv508405 CNV Loss 20534489
nsv462920 CNV Loss 19166990

Variation tolerance for KIF6 Gene

Residual Variation Intolerance Score: 83.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.54; 64.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIF6 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF6 Gene

Disorders for KIF6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KIF6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • ordinary smallpox
- elite association
Search KIF6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KIF6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with KIF6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIF6 Gene

Publications for KIF6 Gene

  1. A mitotic kinesin-6, Pav-KLP, mediates interdependent cortical reorganization and spindle dynamics in Drosophila embryos. (PMID: 20442250) Sommi P. … Mogilner A. (J. Cell. Sci. 2010) 23 67
  2. Dynamics of myosin, microtubules, and Kinesin-6 at the cortex during cytokinesis in Drosophila S2 cells. (PMID: 19720876) Vale R.D. … Griffis E.R. (J. Cell Biol. 2009) 23 67
  3. Clustering of centralspindlin is essential for its accumulation to the central spindle and the midbody. (PMID: 19962307) Hutterer A. … Mishima M. (Curr. Biol. 2009) 23 67
  4. Cell division: the need for speed. (PMID: 20064404) Miller A.L. … Bement W.M. (Curr. Biol. 2009) 23 67
  5. A kinesin family member 6 variant is associated with coronary heart disease in the Women's Health Study. (PMID: 18222354) Shiffman D. … Ridker P.M. (J. Am. Coll. Cardiol. 2008) 23 67

Products for KIF6 Gene

Sources for KIF6 Gene

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