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Aliases for KIF6 Gene

Aliases for KIF6 Gene

  • Kinesin Family Member 6 2 3 5
  • C6orf102 3 4
  • Chromosome 6 Open Reading Frame 102 2
  • Kinesin-Like Protein KIF6 3
  • DJ1043E3.1 3
  • DJ137F1.4 3
  • DJ188D3.1 3

External Ids for KIF6 Gene

Previous HGNC Symbols for KIF6 Gene

  • C6orf102

Previous GeneCards Identifiers for KIF6 Gene

  • GC00U914198
  • GC06U900645
  • GC06M039412
  • GC06M039297
  • GC06M039021
  • GC06M039330
  • GC06M039335
  • GC06M039392
  • GC06M039431
  • GC06M039445

Summaries for KIF6 Gene

Entrez Gene Summary for KIF6 Gene

  • This gene encodes a member of a family of molecular motors which are involved in intracellular transport of protein complexes, membrane organelles, and messenger ribonucleic acid along microtubules. Kinesins function as homodimeric molecules with two N-terminal head domains that move along microtubules and two C-terminal tail domains that interact with the transported cargo, either directly or indirectly, through adapter molecules. This gene is ubiquitously expressed in coronary arteries and other vascular tissue. A naturally occurring mutation in this gene is associated with coronary heart disease. [provided by RefSeq, May 2017]

GeneCards Summary for KIF6 Gene

KIF6 (Kinesin Family Member 6) is a Protein Coding gene. Diseases associated with KIF6 include Smallpox. Among its related pathways are Golgi-to-ER retrograde transport and Factors involved in megakaryocyte development and platelet production. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF9.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF6 Gene

Genomics for KIF6 Gene

Regulatory Elements for KIF6 Gene

Enhancers for KIF6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G039725 0.9 ENCODE 23 +0.0 31 0.8 ARID4B SIN3A ZNF121 ELK1 ZNF143 SP3 SP5 YY2 MXD4 NFYC KIF6 GC06P041076
GH06G039706 0.8 dbSUPER 23.1 +11.3 11344 15.9 ATF1 ZNF792 MAX CEBPG ZIC2 NFE2 NR2F6 CREM IKZF2 ZNF10 KIF6 DAAM2 GC06P041076
GH06G039662 0.5 dbSUPER 22.7 +59.7 59692 5.8 HDAC2 KDM1A NFE2 RAD21 MAFK KIF6 DAAM2 GC06P041076
GH06G039424 1 Ensembl ENCODE 8.8 +299.5 299458 2.3 NFIB JUN BACH1 PRDM10 RELB FOS IKZF2 MTA2 NR2F1 DPF2 KIF6 GC06M039512 GC06M039472
GH06G039652 0.4 dbSUPER 21.6 +71.7 71723 2.0 TCF12 EGR1 KIF6 GC06P041076
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KIF6 on UCSC Golden Path with GeneCards custom track

Promoters for KIF6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000196676 71 1199 ARID4B SIN3A ZNF121 ELK1 ZNF143 SP3 SP5 YY2 MXD4 NFYC

Genomic Location for KIF6 Gene

39,329,990 bp from pter
39,725,472 bp from pter
395,483 bases
Minus strand

Genomic View for KIF6 Gene

Genes around KIF6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF6 Gene

Proteins for KIF6 Gene

  • Protein details for KIF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kinesin-like protein KIF6
    Protein Accession:
    Secondary Accessions:
    • Q2MDE3
    • Q2MDE4
    • Q5T8J6
    • Q6ZWE3
    • Q86T87
    • Q8WTV4

    Protein attributes for KIF6 Gene

    814 amino acids
    Molecular mass:
    92569 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KIF6 Gene


neXtProt entry for KIF6 Gene

Post-translational modifications for KIF6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KIF6 Gene

Domains & Families for KIF6 Gene

Gene Families for KIF6 Gene

Protein Domains for KIF6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIF6: view

Function for KIF6 Gene

Gene Ontology (GO) - Molecular Function for KIF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity IEA,IBA --
GO:0005515 protein binding IPI 16189514
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
GO:0016887 ATPase activity IBA --
genes like me logo Genes that share ontologies with KIF6: view
genes like me logo Genes that share phenotypes with KIF6: view

Animal Model Products

CRISPR Products

miRNA for KIF6 Gene

miRTarBase miRNAs that target KIF6

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIF6 Gene

Localization for KIF6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF6 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIF6 gene
Compartment Confidence
cytoskeleton 3
mitochondrion 3
cytosol 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for KIF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001673 male germ cell nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005871 kinesin complex IBA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with KIF6: view

Pathways & Interactions for KIF6 Gene

genes like me logo Genes that share pathways with KIF6: view

Gene Ontology (GO) - Biological Process for KIF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007018 microtubule-based movement IEA,IBA --
genes like me logo Genes that share ontologies with KIF6: view

No data available for SIGNOR curated interactions for KIF6 Gene

Drugs & Compounds for KIF6 Gene

(2) Drugs for KIF6 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
atorvastatin Approved Pharma Competitive, Inhibitor 0
Pravastatin Approved Pharma Competitive, Inhibitor 150
genes like me logo Genes that share compounds with KIF6: view

Transcripts for KIF6 Gene

Unigene Clusters for KIF6 Gene

Kinesin family member 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c · 16d ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
SP1: - - - - -
SP2: - - -
SP3: - - - -

ExUns: 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26a · 26b
SP1: -
SP2: - - -
SP3: -
SP5: -
SP6: - - -

Relevant External Links for KIF6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KIF6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIF6 Gene

mRNA differential expression in normal tissues according to GTEx for KIF6 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.9), Brain - Substantia nigra (x5.2), and Brain - Hippocampus (x4.2).

Protein differential expression in normal tissues from HIPED for KIF6 Gene

This gene is overexpressed in Fetal heart (37.0) and Heart (25.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KIF6 Gene

Protein tissue co-expression partners for KIF6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KIF6 Gene:


SOURCE GeneReport for Unigene cluster for KIF6 Gene:


Evidence on tissue expression from TISSUES for KIF6 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with KIF6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIF6 Gene

Orthologs for KIF6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIF6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KIF6 34 35
  • 98.89 (n)
(Canis familiaris)
Mammalia KIF6 34 35
  • 86.75 (n)
(Mus musculus)
Mammalia Kif6 34 16 35
  • 81.59 (n)
(Rattus norvegicus)
Mammalia Kif6 34
  • 80.67 (n)
(Bos Taurus)
Mammalia KIF6 35
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia KIF6 35
  • 79 (a)
(Monodelphis domestica)
Mammalia KIF6 35
  • 67 (a)
(Gallus gallus)
Aves KIF6 34 35
  • 69.56 (n)
(Anolis carolinensis)
Reptilia KIF6 35
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kif6 34
  • 66.62 (n)
(Danio rerio)
Actinopterygii kif6 34 35
  • 61.6 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 50 (a)
Species where no ortholog for KIF6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIF6 Gene

Gene Tree for KIF6 (if available)
Gene Tree for KIF6 (if available)

Paralogs for KIF6 Gene

Variants for KIF6 Gene

Sequence variations from dbSNP and Humsavar for KIF6 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_036217 A breast cancer sample
rs20455 drug-response 39,357,302(-) ATGAA(C/T)GGTCC intron-variant, reference, missense
rs1000008180 -- 39,523,602(+) CTAGG(C/T)CTCAG intron-variant
rs1000014422 -- 39,534,542(+) AGCCT(A/C)CAAGA intron-variant
rs1000019602 -- 39,596,936(+) AGCAA(C/T)GATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF6 Gene

Variant ID Type Subtype PubMed ID
esv2521582 CNV insertion 19546169
esv2731955 CNV deletion 23290073
esv3347114 CNV insertion 20981092
esv3567682 CNV deletion 23714750
esv3608755 CNV loss 21293372
esv3608757 CNV loss 21293372
esv3608758 CNV loss 21293372
esv3608760 CNV loss 21293372
esv3608761 CNV gain 21293372
nsv1074392 CNV deletion 25765185
nsv1115714 CNV duplication 24896259
nsv1137073 CNV deletion 24896259
nsv1150331 CNV duplication 26484159
nsv1161378 CNV duplication 26073780
nsv428145 CNV gain 18775914
nsv462920 CNV loss 19166990
nsv476071 CNV novel sequence insertion 20440878
nsv477296 CNV novel sequence insertion 20440878
nsv508405 CNV deletion 20534489
nsv5271 CNV insertion 18451855
nsv602964 CNV loss 21841781
nsv830644 CNV loss 17160897
nsv830645 CNV loss 17160897

Variation tolerance for KIF6 Gene

Residual Variation Intolerance Score: 83.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.54; 64.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIF6 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF6 Gene

Disorders for KIF6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KIF6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • ordinary smallpox
- elite association - COSMIC cancer census association via MalaCards
Search KIF6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KIF6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with KIF6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIF6 Gene

Publications for KIF6 Gene

  1. Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials. (PMID: 18222353) Iakoubova O.A. … Sacks F.M. (J. Am. Coll. Cardiol. 2008) 3 22 46 64
  2. A kinesin family member 6 variant is associated with coronary heart disease in the Women's Health Study. (PMID: 18222354) Shiffman D. … Ridker P.M. (J. Am. Coll. Cardiol. 2008) 3 22 46 64
  3. Polymorphism in KIF6 gene and benefit from statins after acute coronary syndromes: results from the PROVE IT-TIMI 22 study. (PMID: 18222355) Iakoubova O.A. … Braunwald E. (J. Am. Coll. Cardiol. 2008) 3 22 46 64
  4. Genetic variants in the KIF6 region and coronary event reduction from statin therapy. (PMID: 20886236) Li Y. … Iakoubova O.A. (Hum. Genet. 2011) 3 46 64
  5. KIF6 Trp719Arg polymorphism and the effect of statin therapy in elderly patients: results from the PROSPER study. (PMID: 20215968) Iakoubova O.A. … Shepherd J. (Eur J Cardiovasc Prev Rehabil 2010) 3 46 64

Products for KIF6 Gene

Sources for KIF6 Gene

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