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Aliases for KIF6 Gene

Aliases for KIF6 Gene

  • Kinesin Family Member 6 2 3 5
  • C6orf102 3 4
  • Chromosome 6 Open Reading Frame 102 2
  • DJ1043E3.1 3
  • DJ137F1.4 3
  • DJ188D3.1 3

External Ids for KIF6 Gene

Previous HGNC Symbols for KIF6 Gene

  • C6orf102

Previous GeneCards Identifiers for KIF6 Gene

  • GC00U914198
  • GC06U900645
  • GC06M039412
  • GC06M039297
  • GC06M039021
  • GC06M039330
  • GC06M039335

Summaries for KIF6 Gene

GeneCards Summary for KIF6 Gene

KIF6 (Kinesin Family Member 6) is a Protein Coding gene. Diseases associated with KIF6 include smallpox. Among its related pathways are Golgi-to-ER retrograde transport and Factors involved in megakaryocyte development and platelet production. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF12.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF6 Gene

Genomics for KIF6 Gene

Regulatory Elements for KIF6 Gene

Enhancers for KIF6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KIF6 on UCSC Golden Path with GeneCards custom track

Promoters for KIF6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KIF6 on UCSC Golden Path with GeneCards custom track

Genomic Location for KIF6 Gene

Chromosome:
6
Start:
39,329,990 bp from pter
End:
39,725,472 bp from pter
Size:
395,483 bases
Orientation:
Minus strand

Genomic View for KIF6 Gene

Genes around KIF6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF6 Gene

Proteins for KIF6 Gene

  • Protein details for KIF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZMV9-KIF6_HUMAN
    Recommended name:
    Kinesin-like protein KIF6
    Protein Accession:
    Q6ZMV9
    Secondary Accessions:
    • Q2MDE3
    • Q2MDE4
    • Q5T8J6
    • Q6ZWE3
    • Q86T87
    • Q8WTV4

    Protein attributes for KIF6 Gene

    Size:
    814 amino acids
    Molecular mass:
    92569 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KIF6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF6 Gene

Proteomics data for KIF6 Gene at MOPED

Post-translational modifications for KIF6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KIF6 Gene

Domains & Families for KIF6 Gene

Gene Families for KIF6 Gene

Protein Domains for KIF6 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZMV9

UniProtKB/Swiss-Prot:

KIF6_HUMAN :
  • Contains 1 kinesin motor domain.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Domain:
  • Contains 1 kinesin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIF6: view

Function for KIF6 Gene

Gene Ontology (GO) - Molecular Function for KIF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0005524 ATP binding IEA --
GO:0016887 ATPase activity IBA --
genes like me logo Genes that share ontologies with KIF6: view
genes like me logo Genes that share phenotypes with KIF6: view

Animal Model Products

miRNA for KIF6 Gene

miRTarBase miRNAs that target KIF6

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIF6 Gene

Localization for KIF6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF6 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIF6 Gene COMPARTMENTS Subcellular localization image for KIF6 gene
Compartment Confidence
cytoskeleton 3
cytosol 3
mitochondrion 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for KIF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001673 male germ cell nucleus IEA --
genes like me logo Genes that share ontologies with KIF6: view

Pathways & Interactions for KIF6 Gene

genes like me logo Genes that share pathways with KIF6: view

Gene Ontology (GO) - Biological Process for KIF6 Gene

None

No data available for SIGNOR curated interactions for KIF6 Gene

Drugs & Compounds for KIF6 Gene

(2) Drugs for KIF6 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
atorvastatin Approved Pharma Competitive, Inhibitor 0
Pravastatin Approved Pharma Competitive, Inhibitor 145
genes like me logo Genes that share compounds with KIF6: view

Transcripts for KIF6 Gene

Unigene Clusters for KIF6 Gene

Kinesin family member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIF6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c · 16d ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
SP1: - - - - -
SP2: - - -
SP3: - - - -
SP4:
SP5:
SP6:
SP7:

ExUns: 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26a · 26b
SP1: -
SP2: - - -
SP3: -
SP4:
SP5: -
SP6: - - -
SP7:

Relevant External Links for KIF6 Gene

GeneLoc Exon Structure for
KIF6
ECgene alternative splicing isoforms for
KIF6

Expression for KIF6 Gene

mRNA expression in normal human tissues for KIF6 Gene

mRNA differential expression in normal tissues according to GTEx for KIF6 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.9), Brain - Substantia nigra (x5.2), and Brain - Hippocampus (x4.2).

Protein differential expression in normal tissues from HIPED for KIF6 Gene

This gene is overexpressed in Fetal heart (37.0) and Heart (25.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIF6 Gene



SOURCE GeneReport for Unigene cluster for KIF6 Gene Hs.588202

genes like me logo Genes that share expression patterns with KIF6: view

Protein tissue co-expression partners for KIF6 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for KIF6 Gene

Orthologs for KIF6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIF6 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia KIF6 35
  • 86.75 (n)
  • 86.34 (a)
KIF6 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kif6 35
  • 81.59 (n)
  • 83.42 (a)
Kif6 16
Kif6 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KIF6 35
  • 98.89 (n)
  • 98.4 (a)
KIF6 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kif6 35
  • 80.67 (n)
  • 83.29 (a)
cow
(Bos Taurus)
Mammalia KIF6 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIF6 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF6 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIF6 35
  • 69.56 (n)
  • 68.84 (a)
KIF6 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIF6 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kif6 35
  • 66.62 (n)
  • 69.88 (a)
zebrafish
(Danio rerio)
Actinopterygii kif6 35
  • 61.6 (n)
  • 61.65 (a)
kif6 36
  • 55 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToOne
Species with no ortholog for KIF6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIF6 Gene

ENSEMBL:
Gene Tree for KIF6 (if available)
TreeFam:
Gene Tree for KIF6 (if available)

Paralogs for KIF6 Gene

Paralogs for KIF6 Gene

genes like me logo Genes that share paralogs with KIF6: view

Variants for KIF6 Gene

Sequence variations from dbSNP and Humsavar for KIF6 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs20455 - 39,357,302(-) ATGAA(C/T)GGTCC reference, missense
VAR_036217 A breast cancer sample
rs2273063 - 39,540,113(-) CTTCC(A/G/T)CCTAG intron-variant, reference, missense
rs1016161 -- 39,408,460(-) TAACA(A/G)ACATT intron-variant
rs1021740 -- 39,720,506(-) TTTCT(A/G)TATCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF6 Gene

Variant ID Type Subtype PubMed ID
nsv830644 CNV Loss 17160897
nsv830645 CNV Loss 17160897
nsv885822 CNV Loss 21882294
esv2731955 CNV Deletion 23290073
esv2521582 CNV Insertion 19546169
esv271295 CNV Insertion 20981092
nsv428145 CNV Gain 18775914
nsv885823 CNV Loss 21882294
nsv5271 CNV Insertion 18451855
nsv508405 CNV Loss 20534489
nsv462920 CNV Loss 19166990

Variation tolerance for KIF6 Gene

Residual Variation Intolerance Score: 83.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.54; 64.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIF6 Gene

HapMap Linkage Disequilibrium report
KIF6
Human Gene Mutation Database (HGMD)
KIF6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF6 Gene

Disorders for KIF6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KIF6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
smallpox
  • ordinary smallpox
- elite association - COSMIC cancer census association via MalaCards
Search KIF6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KIF6

Genetic Association Database (GAD)
KIF6
Human Genome Epidemiology (HuGE) Navigator
KIF6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIF6
genes like me logo Genes that share disorders with KIF6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIF6 Gene

Publications for KIF6 Gene

  1. A kinesin family member 6 variant is associated with coronary heart disease in the Women's Health Study. (PMID: 18222354) Shiffman D. … Ridker P.M. (J. Am. Coll. Cardiol. 2008) 3 23 48 67
  2. Polymorphism in KIF6 gene and benefit from statins after acute coronary syndromes: results from the PROVE IT-TIMI 22 study. (PMID: 18222355) Iakoubova O.A. … Braunwald E. (J. Am. Coll. Cardiol. 2008) 3 23
  3. Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials. (PMID: 18222353) Iakoubova O.A. … Sacks F.M. (J. Am. Coll. Cardiol. 2008) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries. (PMID: 24556642) Zeng Z. … Shaffer J.R. (Caries Res. 2014) 3

Products for KIF6 Gene

Sources for KIF6 Gene

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