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Aliases for KIF6 Gene

Aliases for KIF6 Gene

  • Kinesin Family Member 6 2 3 5
  • C6orf102 3 4
  • Chromosome 6 Open Reading Frame 102 2
  • Kinesin-Like Protein KIF6 3
  • DJ1043E3.1 3
  • DJ137F1.4 3
  • DJ188D3.1 3

External Ids for KIF6 Gene

Previous HGNC Symbols for KIF6 Gene

  • C6orf102

Previous GeneCards Identifiers for KIF6 Gene

  • GC00U914198
  • GC06U900645
  • GC06M039412
  • GC06M039297
  • GC06M039021
  • GC06M039330
  • GC06M039335
  • GC06M039392
  • GC06M039431
  • GC06M039445
  • GC06M039480

Summaries for KIF6 Gene

Entrez Gene Summary for KIF6 Gene

  • This gene encodes a member of a family of molecular motors which are involved in intracellular transport of protein complexes, membrane organelles, and messenger ribonucleic acid along microtubules. Kinesins function as homodimeric molecules with two N-terminal head domains that move along microtubules and two C-terminal tail domains that interact with the transported cargo, either directly or indirectly, through adapter molecules. This gene is ubiquitously expressed in coronary arteries and other vascular tissue. A naturally occurring mutation in this gene is associated with coronary heart disease. [provided by RefSeq, May 2017]

GeneCards Summary for KIF6 Gene

KIF6 (Kinesin Family Member 6) is a Protein Coding gene. Diseases associated with KIF6 include Smallpox. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Golgi-to-ER retrograde transport. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF9.

Additional gene information for KIF6 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF6 Gene

Genomics for KIF6 Gene

Regulatory Elements for KIF6 Gene

Enhancers for KIF6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H039725 0.9 ENCODE 23 +0.0 31 0 ARID4B SIN3A BMI1 ZNF121 ELK1 EGR1 ZNF143 MIXL1 SP3 ZNF362 KIF6 GC06P041763
GH06H039706 0.7 dbSUPER 23.1 +11.3 11344 15 HLF MAX MNT CEBPG REST ZIC2 ATF2 GATA3 CREB1 FOXP2 KIF6 DAAM2 GC06P041763
GH06H039662 0.5 dbSUPER 22.7 +59.7 59692 5 NFE2 RAD21 MAFK KIF6 DAAM2 GC06P041763
GH06H039652 0.4 dbSUPER 21.6 +71.7 71723 2 TCF12 EGR1 KIF6 GC06P041763
GH06H039424 0.9 Ensembl ENCODE 8.8 +299.5 299458 2 NFIB JUN NR2F2 JUND GATA3 NFIC IKZF1 PRDM10 FOS KIF6 GC06M039549 GC06M039512
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KIF6 on UCSC Golden Path with GeneCards custom track

Promoters for KIF6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000196676 71 1199 ARID4B SIN3A BMI1 ZNF121 ELK1 EGR1 ZNF143 MIXL1 SP3 ZNF362

Genomic Location for KIF6 Gene

Chromosome:
6
Start:
39,329,990 bp from pter
End:
39,725,472 bp from pter
Size:
395,483 bases
Orientation:
Minus strand

Genomic View for KIF6 Gene

Genes around KIF6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF6 Gene

Proteins for KIF6 Gene

  • Protein details for KIF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZMV9-KIF6_HUMAN
    Recommended name:
    Kinesin-like protein KIF6
    Protein Accession:
    Q6ZMV9
    Secondary Accessions:
    • Q2MDE3
    • Q2MDE4
    • Q5T8J6
    • Q6ZWE3
    • Q86T87
    • Q8WTV4

    Protein attributes for KIF6 Gene

    Size:
    814 amino acids
    Molecular mass:
    92569 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KIF6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF6 Gene

Post-translational modifications for KIF6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KIF6 Gene

Domains & Families for KIF6 Gene

Gene Families for KIF6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KIF6 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZMV9

UniProtKB/Swiss-Prot:

KIF6_HUMAN :
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIF6: view

Function for KIF6 Gene

Phenotypes From GWAS Catalog for KIF6 Gene

Gene Ontology (GO) - Molecular Function for KIF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity IEA,IBA --
GO:0005515 protein binding IPI 16189514
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
GO:0016887 ATPase activity IBA --
genes like me logo Genes that share ontologies with KIF6: view
genes like me logo Genes that share phenotypes with KIF6: view

Animal Model Products

CRISPR Products

miRNA for KIF6 Gene

miRTarBase miRNAs that target KIF6

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for KIF6
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIF6 Gene

Localization for KIF6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF6 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIF6 gene
Compartment Confidence
cytoskeleton 3
mitochondrion 3
cytosol 3
nucleus 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for KIF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001673 male germ cell nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005871 kinesin complex IBA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with KIF6: view

Pathways & Interactions for KIF6 Gene

genes like me logo Genes that share pathways with KIF6: view

Gene Ontology (GO) - Biological Process for KIF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007018 microtubule-based movement IEA,IBA --
genes like me logo Genes that share ontologies with KIF6: view

No data available for SIGNOR curated interactions for KIF6 Gene

Drugs & Compounds for KIF6 Gene

(2) Drugs for KIF6 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
atorvastatin Approved Pharma Competitive, Inhibitor 0
Pravastatin Approved Pharma Competitive, Inhibitor 153
genes like me logo Genes that share compounds with KIF6: view

Transcripts for KIF6 Gene

Unigene Clusters for KIF6 Gene

Kinesin family member 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for KIF6
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for KIF6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c · 16d ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
SP1: - - - - -
SP2: - - -
SP3: - - - -
SP4:
SP5:
SP6:
SP7:

ExUns: 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26a · 26b
SP1: -
SP2: - - -
SP3: -
SP4:
SP5: -
SP6: - - -
SP7:

Relevant External Links for KIF6 Gene

GeneLoc Exon Structure for
KIF6
ECgene alternative splicing isoforms for
KIF6

Expression for KIF6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIF6 Gene

mRNA differential expression in normal tissues according to GTEx for KIF6 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.9), Brain - Substantia nigra (x5.2), and Brain - Hippocampus (x4.2).

Protein differential expression in normal tissues from HIPED for KIF6 Gene

This gene is overexpressed in Fetal heart (37.0) and Heart (25.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KIF6 Gene



Protein tissue co-expression partners for KIF6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KIF6 Gene:

KIF6

SOURCE GeneReport for Unigene cluster for KIF6 Gene:

Hs.588202

Evidence on tissue expression from TISSUES for KIF6 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with KIF6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIF6 Gene

Orthologs for KIF6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIF6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF6 33 34
  • 98.89 (n)
dog
(Canis familiaris)
Mammalia KIF6 33 34
  • 86.75 (n)
mouse
(Mus musculus)
Mammalia Kif6 33 16 34
  • 81.59 (n)
rat
(Rattus norvegicus)
Mammalia Kif6 33
  • 80.67 (n)
cow
(Bos Taurus)
Mammalia KIF6 34
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF6 34
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIF6 34
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIF6 33 34
  • 69.56 (n)
lizard
(Anolis carolinensis)
Reptilia KIF6 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kif6 33
  • 66.62 (n)
zebrafish
(Danio rerio)
Actinopterygii kif6 33 34
  • 61.6 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 50 (a)
OneToOne
Species where no ortholog for KIF6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIF6 Gene

ENSEMBL:
Gene Tree for KIF6 (if available)
TreeFam:
Gene Tree for KIF6 (if available)

Paralogs for KIF6 Gene

Paralogs for KIF6 Gene

genes like me logo Genes that share paralogs with KIF6: view

Variants for KIF6 Gene

Sequence variations from dbSNP and Humsavar for KIF6 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_036217 A breast cancer sample
rs20455 drug-response 39,357,302(-) ATGAA(C/T)GGTCC intron-variant, reference, missense
rs1000008180 -- 39,523,602(+) CTAGG(C/T)CTCAG intron-variant
rs1000014422 -- 39,534,542(+) AGCCT(A/C)CAAGA intron-variant
rs1000019602 -- 39,596,936(+) AGCAA(C/T)GATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF6 Gene

Variant ID Type Subtype PubMed ID
esv2521582 CNV insertion 19546169
esv2731955 CNV deletion 23290073
esv3347114 CNV insertion 20981092
esv3567682 CNV deletion 23714750
esv3608755 CNV loss 21293372
esv3608757 CNV loss 21293372
esv3608758 CNV loss 21293372
esv3608760 CNV loss 21293372
esv3608761 CNV gain 21293372
nsv1074392 CNV deletion 25765185
nsv1115714 CNV duplication 24896259
nsv1137073 CNV deletion 24896259
nsv1150331 CNV duplication 26484159
nsv1161378 CNV duplication 26073780
nsv428145 CNV gain 18775914
nsv462920 CNV loss 19166990
nsv476071 CNV novel sequence insertion 20440878
nsv477296 CNV novel sequence insertion 20440878
nsv508405 CNV deletion 20534489
nsv5271 CNV insertion 18451855
nsv602964 CNV loss 21841781
nsv830644 CNV loss 17160897
nsv830645 CNV loss 17160897

Variation tolerance for KIF6 Gene

Residual Variation Intolerance Score: 83.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.54; 64.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIF6 Gene

Human Gene Mutation Database (HGMD)
KIF6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIF6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF6 Gene

Disorders for KIF6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KIF6 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
smallpox
  • ordinary smallpox
- elite association - COSMIC cancer census association via MalaCards
Search KIF6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KIF6

Genetic Association Database (GAD)
KIF6
Human Genome Epidemiology (HuGE) Navigator
KIF6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIF6
genes like me logo Genes that share disorders with KIF6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIF6 Gene

Publications for KIF6 Gene

  1. Polymorphism in KIF6 gene and benefit from statins after acute coronary syndromes: results from the PROVE IT-TIMI 22 study. (PMID: 18222355) Iakoubova OA … Braunwald E (Journal of the American College of Cardiology 2008) 3 22 45 60
  2. A kinesin family member 6 variant is associated with coronary heart disease in the Women's Health Study. (PMID: 18222354) Shiffman D … Ridker PM (Journal of the American College of Cardiology 2008) 3 22 45 60
  3. Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials. (PMID: 18222353) Iakoubova OA … Sacks FM (Journal of the American College of Cardiology 2008) 3 22 45 60
  4. Genetic variants in the KIF6 region and coronary event reduction from statin therapy. (PMID: 20886236) Li Y … Iakoubova OA (Human genetics 2011) 3 45 60
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60

Products for KIF6 Gene

Sources for KIF6 Gene

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