KIF6 Gene

Aliases
for KIF6 gene

Previous GC identifers: GC00U914198 GC06U900645 GC06M039412 GC06M039021

Summaries
for KIF6 gene

Genomic Views
for KIF6 gene

RefSeq DNA sequence:

NC_000006.11  NC_018917.1  NT_007592.15  

SwitchGear Promoter luciferase reporter plasmid: KIF6 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIF6

KIF6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M039297:  view genomic region     (about GC identifiers)

Proteins
for KIF6 gene

Explore the universe of human proteins at neXtProt for KIF6: NX_Q6ZMV9

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: KIF6 OriGene Custom Protein Services for KIF6
	GenScript Custom Purified and Recombinant Proteins Services for KIF6
	Novus Biologicals KIF6 Protein Novus Biologicals KIF6 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for KIF6

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Browse OriGene Antibodies OriGene Custom Antibody Services for KIF6
	GenScript Custom Superior Antibodies Services for KIF6
	Novus Biologicals KIF6 Antibodies
	Abcam antibodies for KIF6
	Uscn Antibodies for KIF6
	ThermoFisher Antibodies for KIF6

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for KIF6
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for KIF6

Protein Domains /
Families
for KIF6 gene

ProtoNet protein and cluster: Q6ZMV9

Function
for KIF6 gene

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for KIF6

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KIF6
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate KIF6:
		hsa-miR-708 hsa-miR-3130-5p hsa-miR-28-5p hsa-miR-452* hsa-miR-3139 hsa-miR-3160-3p
		SwitchGear 3'UTR luciferase reporter plasmid: KIF6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KIF6 (see all 4) OriGene shRNA RFP: KIF6 OriGene siRNA: KIF6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIF6
		Sirion Biotech Custom design and validation of potent shRNA sequences against KIF6

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for KIF6
			Sirion Biotech Customized adenovirus for overexpression of KIF6  Sirion Biotech Customized adenovirus for potent knockdown of KIF6

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIF6 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIF6 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: KIF6 (NM_145027)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KIF6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIF6

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for KIF6
		Search LifeMap BioReagents cell lines for KIF6
		Sirion Biotech Customized stable knockdown cell line services for KIF6  Sirion Biotech Customized inducible knockdown cell line services for KIF6 Sirion Biotech Customized stable overexpressing cell line services for KIF6 Sirion Biotech Customized inducible overexpressing cell line services for KIF6

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF6

Pathways & Interactions
for KIF6 gene

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

Drugs & Compounds
for KIF6 gene

Transcripts
for KIF6 gene

Expression
for KIF6 gene

KIF6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACGGTCCCA

About this image
See KIF6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KIF6

SOURCE GeneReport for Unigene cluster: Hs.588202
    SABiosciences Custom PCR Arrays for KIF6

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIF6 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KIF6
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIF6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIF6

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF6

Orthologs
for KIF6 gene

Paralogs
for KIF6 gene

Paralogs for KIF6 gene

KIF5C²  KIF21A²  KIF11²  KIF3B²  KIF21B²  KIF9²  KIF17²  KIF4B²  

KIF27²  KIF5B²  KIF3A²  KIF4A²  CENPE²  KIF15²  KIF5A²  KIF7²  

KIF3C²  

18/31 SIMAP similar genes for KIF6 using alignment to 11 protein entries:     KIF6_HUMAN (see all proteins) (see all similar genes):

KIFC3    KIF13A    KIF18A    KIF18B    KIF17    KIF5B-ALK

KLP6    KIF9    KIF15    KIF5C    KIF1A    KIF1Bbeta

KIF5B    KIF13B    KIF19    KIF3A    KIF22    KIF27

KIF6 for paralogs           About GeneDecksing

Genomic Variants
for KIF6 gene

10/6415 NCBI SNPs in KIF6 are shown (see all 6415)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1889877201,2		--	39302425(+)	GAAAAG/TAAAAG	1	--	ds5001		0	--	--	--	--
rs77740461,2	C,F,A,H	--	39302432(+)	AAAGTC/TAGTAG	1	--	ds5001		28		NS EA NA WA CSA	2790
rs77742041,2	C,F,A,H	--	39302501(+)	CTACAC/TAGGGG	1	--	ds5001		16		NS EA NA WA CSA	930
rs1446846701,2		--	39302559(+)	GTGTA-/TGTGTGT	1	--	ds5001		0	--	--	--	--
rs93808481,2	C,F,A,H	--	39302614(+)	GCTTCT/CAGAAT	1	--	ds5001		21		NA NS EA WA CSA	2482
rs77542251,2	C,F,A,H	--	39302723(+)	TGTCCT/CGATGG	1	--	ds5001		25		NS EA NA WA CSA	2477
rs1931256551,2		--	39302725(+)	TCCCGA/GTGGGA	1	--	ds5001		0	--	--	--	--
rs1852646961,2		--	39302795(+)	TGGCTC/TGTCTA	1	--	ds5001		0	--	--	--	--
rs18877161,2	C,F,O,A,H	--	39302832(-)	GAGTCG/ACTGTT	1	--	ds5001		26		NA EA MN NS WA CSA	2970
rs728584681,2	C,F	--	39302876(+)	AGGTCC/TCTGTT	1	--	ut31		2		NA EA	240

HapMap Linkage Disequilibrium report for KIF6 (39297766 - 39547766 bp, first 250kb of KIF6)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for KIF6
     1 Indel: 99509
Human Gene Mutation Database (HGMD): KIF6

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIF6

DNA2.0 Custom Variant and Variant Library Synthesis for KIF6

Disorders / Diseases
for KIF6 gene

7 diseases for KIF6

1 Novoseek disease relationship for KIF6 gene    About this table

Publications
for KIF6 gene

PubMed articles for KIF6 gene, integrated from 9 sources (see all 45): (articles sorted by number of sources associating them with KIF6)

Utopia: connect your pdf to the dynamic world of online information

1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
4. A kinesin family member 6 variant is associated with coronary heart disease in the Women's Health Study. (PubMed id 18222354)^{1, 9} Shiffman D....Ridker P.M. (2008)
5. Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials. (PubMed id 18222353)^{1, 9} Iakoubova O.A....Sacks F.M. (2008)
6. Polymorphism in KIF6 gene and benefit from statins after acute coronary syndromes: results from the PROVE IT-TIMI 22 study. (PubMed id 18222355)^{1, 9} Iakoubova O.A....Braunwald E. (2008)
7. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)¹ Lin Y.Y....Boeke J.D. (2012)
8. KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low d ensity lipoprotein cholesterol lowering response to pravastatin, and heart disea se risk reduction in the elderly. (PubMed id 22192511)¹ Akao H....Schaefer E.J. (2012)
9. KLF6 loss of function in human prostate cancer progres sion is implicated in resistance to androgen deprivation. (PubMed id 22819534)¹ Liu X....Ferrari A.C. (2012)
10. Genome-wide association study of antibody response to smallpox vaccine. (PubMed id 22542470)¹ Ovsyannikova I.G....Poland G.A. (2012)

External Searches for KIF6 gene

Genome Databases showing KIF6 gene

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Specialized Databases showing KIF6 gene

Products
for KIF6 gene