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KIF6 Gene

protein-coding   GIFtS: 55
GCID: GC06M039297

Kinesin Family Member 6

(Previous name: chromosome 6 open reading frame 102)
(Previous symbol: C6orf102)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kinesin Family Member 61 2     dJ137F1.42
C6orf1021 2 3     dJ188D3.12
Chromosome 6 Open Reading Frame 1021     Kinesin-Like Protein KIF62
dJ1043E3.12     

External Ids:    HGNC: 212021   Entrez Gene: 2214582   Ensembl: ENSG000001646277   OMIM: 6139195   UniProtKB: Q6ZMV93   

Export aliases for KIF6 gene to outside databases

Previous GC identifers: GC00U914198 GC06U900645 GC06M039412 GC06M039021


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KIF6 Gene:
KIF6 (kinesin family member 6) is a protein-coding gene. GO annotations related to this gene include microtubule binding and microtubule motor activity. An important paralog of this gene is KIF9.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KIF6 gene promoter:
         RP58   AML1a   ATF-2   Pax-2   Pax-2a   HNF-1A   S8   Pax-2b   HNF-1   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKIF6 promoter sequence
   Search Chromatin IP Primers for KIF6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KIF6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.2   Ensembl cytogenetic band:  6p21.2   HGNC cytogenetic band: 6p21.2

KIF6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIF6 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M039297:  view genomic region     (about GC identifiers)

Start:
39,297,766 bp from pter      End:
39,693,181 bp from pter
Size:
395,416 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KIF6_HUMAN, Q6ZMV9 (See protein sequence)
Recommended Name: Kinesin-like protein KIF6  
Size: 814 amino acids; 92569 Da
Secondary accessions: Q2MDE3 Q2MDE4 Q5T8J6 Q6ZWE3 Q86T87 Q8WTV4
Alternative splicing: 4 isoforms:  Q6ZMV9-1   Q6ZMV9-2   Q6ZMV9-3   Q6ZMV9-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KIF6: NX_Q6ZMV9

Explore proteomics data for KIF6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KIF6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001275949.1  NP_001275950.1  NP_001275953.1  NP_659464.3  

    ENSEMBL proteins: 
     ENSP00000409417   ENSP00000287152   ENSP00000377889   ENSP00000229913   ENSP00000404856  
     ENSP00000362312   ENSP00000362311   ENSP00000441435   ENSP00000362309   ENSP00000439064  

    KIF6 Human Recombinant Protein Products:

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    Novus Biologicals KIF6 Protein
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KIF6

     
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    antibodies-online proteins for KIF6 (2 products) 

     
    antibodies-online peptides for KIF6

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    antibodies-online kits for KIF6 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KIF: Kinesins

    4 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR001752 Kinesin_motor_dom
     IPR019821 Kinesin_motor_CS
     IPR027640 Kinesin-like_fam

    Graphical View of Domain Structure for InterPro Entry Q6ZMV9

    ProtoNet protein and cluster: Q6ZMV9

    1 Blocks protein domain: IPB001752 Kinesin

    UniProtKB/Swiss-Prot: KIF6_HUMAN, Q6ZMV9
    Similarity: Belongs to the kinesin-like protein family
    Similarity: Contains 1 kinesin-motor domain


    Find genes that share domains with KIF6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003777microtubule motor activity IEA--
    GO:0005515protein binding IPI16189514
    GO:0005524ATP binding IEA--
    GO:0008017microtubule binding IEA--
         
    Find genes that share ontologies with KIF6           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for KIF6:
     Increased cell number in G2M,   Metaphase cells 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Kif6):
     cardiovascular system 

    Find genes that share phenotypes with KIF6           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for KIF6

    miRNA
    Products:
        
    miRTarBase miRNAs that target KIF6:
    hsa-mir-125a-5p (MIRT045765), hsa-mir-339-5p (MIRT042748)

    Block miRNA regulation of human, mouse, rat KIF6 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate KIF6:
    hsa-miR-708 hsa-miR-3130-5p hsa-miR-28-5p hsa-miR-452* hsa-miR-3139 hsa-miR-3160-3p
    SwitchGear 3'UTR luciferase reporter plasmidKIF6 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KIF6

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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIF6

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KIF6_HUMAN, Q6ZMV9: Cytoplasm, cytoskeleton (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol3
    mitochondrion3
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001673male germ cell nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005871kinesin complex IEA--
    GO:0005874microtubule IEA--

    Find genes that share ontologies with KIF6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KIF6
    Interactions:

        Search GeneGlobe Interaction Network for KIF6

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for KIF6 (Q6ZMV91, 2, 3 ENSP000002871524) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APPBP2Q926241, 2, 3, ENSP000000831824EBI-751100,EBI-743771 MINT-68019 I2D: score=4 STRING: ENSP00000083182
    SIRT5ENSP000003685524STRING: ENSP00000368552
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007018microtubule-based movement IEA--

    Find genes that share ontologies with KIF6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KIF6

    2 PharmGKB related drug/compound annotations for KIF6 gene    About this table
    Drug/compound PharmGKB Annotation
    atorvastatinCA  
    pravastatinCA  



    Find genes that share compounds with KIF6           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KIF6 gene (4 alternative transcripts): 
    NM_001289020.1  NM_001289021.1  NM_001289024.1  NM_145027.4  

    Unigene Cluster for KIF6:

    Kinesin family member 6
    Hs.588202  [show with all ESTs]
    Unigene Representative Sequence: NM_145027
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000458470 ENST00000287152(uc003oot.2 uc011dua.1 uc010jxb.1)
    ENST00000394362(uc003oos.2) ENST00000229913 ENST00000441975 ENST00000482238
    ENST00000465719(uc003oou.3) ENST00000373216(uc010jxa.1) ENST00000373215
    ENST00000538893 ENST00000373213(uc010jwz.1) ENST00000541946
    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate KIF6:
    hsa-miR-708 hsa-miR-3130-5p hsa-miR-28-5p hsa-miR-452* hsa-miR-3139 hsa-miR-3160-3p
    SwitchGear 3'UTR luciferase reporter plasmidKIF6 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for KIF6
    Predesigned siRNA for gene silencing in human, mouse, rat KIF6
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    GenScript: all cDNA clones in your preferred vector: KIF6 (NM_145027)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIF6
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for KIF6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KIF6
      QuantiTect SYBR Green Assays in human, mouse, rat KIF6
      QuantiFast Probe-based Assays in human, mouse, rat KIF6

    Additional mRNA sequence: 

    AK131471.1 BC022074.2 BC043552.1 BC098418.1 BC117307.1 BC143444.1 BC143445.1 BX649045.1 

    11 DOTS entries:

    DT.99930082  DT.97822241  DT.91679693  DT.101960199  DT.40244026  DT.40287381  DT.95187832  DT.429768 
    DT.100666855  DT.40307652  DT.75191915 

    Selected AceView cDNA sequences (see all 39):

    AL041547 AI352520 BE858267 BX114379 BC043552 BX649045 BX111141 BE223014 
    BC022074 BF057276 AI168595 BX106415 BG189781 NM_145027 BI118088 AL832634 
    AI026880 AK097521 AI693047 AK123217 AI222076 AK131471 BM667910 BM696570 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KIF6 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c · 16d ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
    SP1:              -           -                                                                             -     -     -                                       
    SP2:                                                                                                        -     -     -                                       
    SP3:                                                                                                        -     -     -     -                                 
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26a · 26b
    SP1:                                -               
    SP2:        -     -                 -               
    SP3:                                -               
    SP4:                                                
    SP5:                                -               


    ECgene alternative splicing isoforms for KIF6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KIF6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACGGTCCCA
    KIF6 Expression
    About this image

    KIF6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KIF6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.588202
        Custom PCR Arrays for KIF6
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KIF6 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kif61 , 5 kinesin family member 61, 5 81.59(n)1
    83.42(a)1
      17 (25.78 cM)5
    3199911  NM_177052.31  NP_796026.21 
     496151365 
    chicken
    (Gallus gallus)
    Aves KIF61 kinesin family member 6 69.56(n)
    68.84(a)
      428572  XM_003640945.2  XP_003640993.2 
    lizard
    (Anolis carolinensis)
    Reptilia KIF66
    kinesin family member 6
    65(a)
    1 ↔ 1
    1(246699317-246901752)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia kif61 kinesin family member 6 66.62(n)
    69.88(a)
      100127668  NM_001113011.1  NP_001106482.1 
    zebrafish
    (Danio rerio)
    Actinopterygii kif61 kinesin family member 6 61.6(n)
    61.65(a)
      553436  NM_001077431.1  NP_001070899.1 


    ENSEMBL Gene Tree for KIF6 (if available)
    TreeFam Gene Tree for KIF6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KIF6 gene
    KIF92  
    Selected SIMAP similar genes for KIF6 using alignment to 11 protein entries:     KIF6_HUMAN (see all proteins) (see all similar genes):
    KIFC3    KIF13A    KIF18A    KIF18B    A20    KIF17
    KIF28P    KIF5B-ALK    R11    R12    KIF9    KIF15
    KIF5C    KIF12    KIF1A    KIF1Bbeta    KIF5B    KIF13B

    Find genes that share paralogs with KIF6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KIF6 (see all 7519)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0362174
    A breast cancer sample4--see VAR_0362172 A E mis40--------
    rs1889877201,2
    C--39302425(+) GAAAAG/TAAAAG 1 -- ds50010--------
    rs77740461,2
    C,F,A,H--39302432(+) AAAGTC/TAGTAG 1 -- ds500128Minor allele frequency- T:0.31NS EA NA WA CSA 2790
    rs77742041,2
    C,F,A,H--39302501(+) CTACAC/TAGGGG 1 -- ds500116Minor allele frequency- T:0.32NS EA NA WA CSA 930
    rs1446846701,2
    C--39302559(+) GTGTA-/TGTGTGT 1 -- ds50010--------
    rs93808481,2
    C,F,A,H--39302614(+) GCTTCT/CAGAAT 1 -- ds500121Minor allele frequency- C:0.27NA NS EA WA CSA 2482
    rs77542251,2
    C,F,A,H--39302723(+) TGTCCT/CGATGG 1 -- ds500125Minor allele frequency- C:0.36NS EA NA WA CSA 2477
    rs1931256551,2
    --39302725(+) TCCCGA/GTGGGA 1 -- ds50010--------
    rs1852646961,2
    --39302795(+) TGGCTC/TGTCTA 1 -- ds50010--------
    rs18877161,2
    C,F,O,A,H--39302832(-) GAGTCG/ACTGTT 1 -- ds500126Minor allele frequency- A:0.47NA EA MN NS WA CSA 2970

    HapMap Linkage Disequilibrium report for KIF6 (39297766 - 39547766 bp, first 250kb of KIF6)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for KIF6 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2731955CNV Deletion23290073
    esv2521582CNV Insertion19546169
    esv271295CNV Insertion20981092
    nsv5271CNV Insertion18451855
    nsv885822CNV Loss21882294
    nsv830644CNV Loss17160897
    nsv885823CNV Loss21882294
    nsv508405CNV Loss20534489
    nsv830645CNV Loss17160897
    nsv462920CNV Loss19166990

    Human Gene Mutation Database (HGMD): KIF6
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KIF6
    DNA2.0 Custom Variant and Variant Library Synthesis for KIF6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613919    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for KIF6:
    Myocardial infarction

    Find genes that share disorders with KIF6           About GenesLikeMe

    1 Novoseek inferred disease relationship for KIF6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    coronary heart disease 23.4 2 18222354 (2)

    Genetic Association Database (GAD): KIF6
    Human Genome Epidemiology (HuGE) Navigator: KIF6 (16 documents)

    Export disorders for KIF6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KIF6 gene, integrated from 10 sources (see all 49):
    (articles sorted by number of sources associating them with KIF6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A kinesin family member 6 variant is associated with coronary heart disease in the Women's Health Study. (PubMed id 18222354)1, 4, 9 Shiffman D....Ridker P.M. (J. Am. Coll. Cardiol. 2008)
    2. Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials. (PubMed id 18222353)1, 4, 9 Iakoubova O.A....Sacks F.M. (J. Am. Coll. Cardiol. 2008)
    3. Polymorphism in KIF6 gene and benefit from statins after acute coronary syndromes: results from the PROVE IT-TIMI 22 study. (PubMed id 18222355)1, 4, 9 Iakoubova O.A....Braunwald E. (J. Am. Coll. Cardiol. 2008)
    4. Genetic variants in the KIF6 region and coronary event reduction from statin therapy. (PubMed id 20886236)1, 4 Li Y....Iakoubova O.A. (Hum. Genet. 2011)
    5. Investigation of KIF6 Trp719Arg in a case-control study of myocardial infarction: a Costa Rican population. (PubMed id 20927332)1, 4 Bare L.A....Campos H. (PLoS ONE 2010)
    6. Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies. (PubMed id 20933357)1, 4 Assimes T.L....Quertermous T. (J. Am. Coll. Cardiol. 2010)
    7. Effect of pravastatin therapy on coronary events in carriers of the KIF6 719Arg allele from the cholesterol and recurrent events trial. (PubMed id 20403483)1, 4 Shiffman D....Sacks F.M. (Am. J. Cardiol. 2010)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    9. KIF6 Trp719Arg polymorphism and the effect of statin therapy in elderly patients: results from the PROSPER study. (PubMed id 20215968)1, 4 Iakoubova O.A....Shepherd J. (amp 2010)
    10. Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1, 4 Luke M.M....Psaty B.M. ( a journal of cerebral circulation 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 221458 HGNC: 21202 AceView: C6orf102 Ensembl:ENSG00000164627 euGenes: HUgn221458
    ECgene: KIF6 H-InvDB: KIF6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KIF6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for KIF6 gene:
    Search GeneIP for patents involving KIF6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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