Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KIF5C Gene

Aliases for KIF5C Gene

  • Kinesin Family Member 5C 2 3
  • NKHC2 3 4 6
  • Kinesin Heavy Chain Neuron-Specific 2 3 4
  • CDCBM2 3 6
  • Kinesin, Heavy Chain, Neuron-Specific 3
  • Kinesin Heavy Chain Isoform 5C 3
  • KIAA0531 4
  • NKHC-2 3
  • KINN 3
  • NKHC 3

External Ids for KIF5C Gene

Previous GeneCards Identifiers for KIF5C Gene

  • GC02M148723
  • GC02M149409
  • GC02P149805
  • GC02P149996
  • GC02P149466
  • GC02P149349
  • GC02P149632
  • GC02P141630

Summaries for KIF5C Gene

GeneCards Summary for KIF5C Gene

KIF5C (Kinesin Family Member 5C) is a Protein Coding gene. Diseases associated with KIF5C include cortical dysplasia, complex, with other brain malformations 2 and cortical dysplasia, complex, with other brain malformations. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Circadian entrainment. GO annotations related to this gene include microtubule binding and microtubule motor activity. An important paralog of this gene is KIF3C.

UniProtKB/Swiss-Prot for KIF5C Gene

  • Mediates dendritic trafficking of mRNAs (By similarity). Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport.

Gene Wiki entry for KIF5C Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF5C Gene

Genomics for KIF5C Gene

Regulatory Elements for KIF5C Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KIF5C Gene

Start:
148,875,223 bp from pter
End:
149,026,759 bp from pter
Size:
151,537 bases
Orientation:
Plus strand

Genomic View for KIF5C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIF5C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF5C Gene

Proteins for KIF5C Gene

  • Protein details for KIF5C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60282-KIF5C_HUMAN
    Recommended name:
    Kinesin heavy chain isoform 5C
    Protein Accession:
    O60282
    Secondary Accessions:
    • O95079
    • Q2YDC5

    Protein attributes for KIF5C Gene

    Size:
    957 amino acids
    Molecular mass:
    109495 Da
    Quaternary structure:
    • Oligomer composed of two heavy chains and two light chains. Interacts with GRIP1 and KLC3 (By similarity). Interacts with TRAK1.
    SequenceCaution:
    • Sequence=BAA25457.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for KIF5C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF5C Gene

Proteomics data for KIF5C Gene at MOPED

Post-translational modifications for KIF5C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIF5C Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KIF5C Gene

Domains for KIF5C Gene

Gene Families for KIF5C Gene

HGNC:
  • KIF :Kinesins

Protein Domains for KIF5C Gene

Suggested Antigen Peptide Sequences for KIF5C Gene

Graphical View of Domain Structure for InterPro Entry

O60282

UniProtKB/Swiss-Prot:

KIF5C_HUMAN :
  • O60282
Domain:
  • Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles
  • Contains 1 kinesin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily.
genes like me logo Genes that share domains with KIF5C: view

Function for KIF5C Gene

Molecular function for KIF5C Gene

UniProtKB/Swiss-Prot Function: Mediates dendritic trafficking of mRNAs (By similarity). Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport.

Gene Ontology (GO) - Molecular Function for KIF5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity TAS 9782088
GO:0005515 protein binding IPI 15644324
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed IBA --
genes like me logo Genes that share ontologies with KIF5C: view

Phenotypes for KIF5C Gene

genes like me logo Genes that share phenotypes with KIF5C: view

Animal Models for KIF5C Gene

MGI Knock Outs for KIF5C:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIF5C

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for KIF5C Gene

Localization for KIF5C Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF5C Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIF5C Gene COMPARTMENTS Subcellular localization image for KIF5C gene
Compartment Confidence
cytoskeleton 4
cytosol 3
nucleus 2
peroxisome 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for KIF5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005871 kinesin complex IBA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with KIF5C: view

Pathways for KIF5C Gene

genes like me logo Genes that share pathways with KIF5C: view

Pathways by source for KIF5C Gene

1 KEGG pathway for KIF5C Gene
1 GeneGo (Thomson Reuters) pathway for KIF5C Gene

Gene Ontology (GO) - Biological Process for KIF5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006996 organelle organization TAS 9782088
GO:0007018 microtubule-based movement IBA --
GO:0007411 axon guidance IBA --
GO:0008104 protein localization IBA --
genes like me logo Genes that share ontologies with KIF5C: view

Transcripts for KIF5C Gene

Unigene Clusters for KIF5C Gene

Kinesin family member 5C:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIF5C

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KIF5C

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF5C Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for KIF5C Gene

GeneLoc Exon Structure for
KIF5C
ECgene alternative splicing isoforms for
KIF5C

Expression for KIF5C Gene

mRNA expression in normal human tissues for KIF5C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIF5C Gene

This gene is overexpressed in Brain - Amygdala (5.8), Brain - Anterior cingulate cortex (BA24) (5.1), Brain - Cortex (5.0), Brain - Frontal Cortex (BA9) (4.7), Brain - Hippocampus (4.6), and Brain - Cerebellar Hemisphere (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIF5C Gene

SOURCE GeneReport for Unigene cluster for KIF5C Gene Hs.435557

mRNA Expression by UniProt/SwissProt for KIF5C Gene

O60282-KIF5C_HUMAN
Tissue specificity: Highest expression in brain, prostate and testis, and moderate expression in kidney, small intestine and ovary
genes like me logo Genes that share expressions with KIF5C: view

In Situ Assay Products

Orthologs for KIF5C Gene

This gene was present in the common ancestor of animals.

Orthologs for KIF5C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF5C 35
  • 99.65 (n)
  • 100 (a)
KIF5C 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIF5C 35
  • 93.03 (n)
  • 98.54 (a)
KIF5C 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIF5C 35
  • 92.76 (n)
  • 98.85 (a)
KIF5C 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kif5c 35
  • 89.75 (n)
  • 98.33 (a)
Kif5c 16
Kif5c 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 31 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia KIF5C 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kif5c 35
  • 90.12 (n)
  • 98.32 (a)
chicken
(Gallus gallus)
Aves KIF5C 35
  • 84.41 (n)
  • 97.14 (a)
KIF5C 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIF5C 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kif5c 35
  • 78.33 (n)
  • 89.18 (a)
Str.12975 35
zebrafish
(Danio rerio)
Actinopterygii kif5c 35
  • 73.99 (n)
  • 80.17 (a)
kif5c 36
  • 76 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Khc 36
  • 61 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-116 36
  • 54 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 63 (a)
OneToMany
Species with no ortholog for KIF5C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIF5C Gene

ENSEMBL:
Gene Tree for KIF5C (if available)
TreeFam:
Gene Tree for KIF5C (if available)

Paralogs for KIF5C Gene

genes like me logo Genes that share paralogs with KIF5C: view

Variants for KIF5C Gene

Sequence variations from dbSNP and Humsavar for KIF5C Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs952141 -- 149,026,953(+) TAATT(G/T)TTTTT downstream-variant-500B, intron-variant
rs4076261 -- 149,015,431(-) AGAGA(C/T)ACTTC intron-variant
rs4076262 -- 149,015,428(-) GATAC(C/T)TCAGA intron-variant
rs4076312 -- 149,014,575(+) GTTAC(G/T)TAAAC intron-variant
rs4130557 -- 148,956,122(+) CCCCA(C/T)TCAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF5C Gene

Variant ID Type Subtype PubMed ID
esv2751831 CNV Gain 17911159
nsv508874 CNV Insertion 20534489
nsv2963 CNV Insertion 18451855
nsv834407 CNV Loss 17160897
nsv834408 CNV Gain 17160897
esv2664279 CNV Deletion 23128226

Relevant External Links for KIF5C Gene

HapMap Linkage Disequilibrium report
KIF5C
Human Gene Mutation Database (HGMD)
KIF5C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF5C Gene

Disorders for KIF5C Gene

(1) OMIM Diseases for KIF5C Gene (604593)

UniProtKB/Swiss-Prot

KIF5C_HUMAN
  • Cortical dysplasia, complex, with other brain malformations 2 (CDCBM2) [MIM:615282]: A disorder of aberrant neuronal migration and disturbed axonal guidance. Clinical features include intrauterine growth retardation, fetal akinesia, seizures, microcephaly, lack of psychomotor development, and arthrogryposis. Brain imaging shows malformations of cortical development, including polymicrogyria, gyral simplification, and thin corpus callosum. {ECO:0000269 PubMed:23603762}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for KIF5C

Genetic Association Database (GAD)
KIF5C
Human Genome Epidemiology (HuGE) Navigator
KIF5C
genes like me logo Genes that share disorders with KIF5C: view

Publications for KIF5C Gene

  1. GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin. (PMID: 15644324) Brickley K. … Stephenson F.A. (J. Biol. Chem. 2005) 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. Cloning and localization of a conventional kinesin motor expressed exclusively in neurons. (PMID: 7514426) Niclas J. … Vale R.D. (Neuron 1994) 2 3
  4. Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin. (PMID: 9361024) Engelender S. … Ross C.A. (Hum. Mol. Genet. 1997) 3 4
  5. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 3 4

Products for KIF5C Gene

Sources for KIF5C Gene

Back to Top

Content