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Aliases for KIF5B Gene

Aliases for KIF5B Gene

  • Kinesin Family Member 5B 2 3 5
  • Conventional Kinesin Heavy Chain 3 4
  • Ubiquitous Kinesin Heavy Chain 3 4
  • KNS1 3 4
  • UKHC 3 4
  • KNS 3 4
  • Epididymis Secretory Protein Li 61 3
  • Kinesin 1 (110-120kD) 3
  • Kinesin Heavy Chain 3
  • HEL-S-61 3
  • KINH 3

External Ids for KIF5B Gene

Previous HGNC Symbols for KIF5B Gene

  • KNS1

Previous GeneCards Identifiers for KIF5B Gene

  • GC10M032448
  • GC10M032304
  • GC10M032340

Summaries for KIF5B Gene

GeneCards Summary for KIF5B Gene

KIF5B (Kinesin Family Member 5B) is a Protein Coding gene. Diseases associated with KIF5B include adenosquamous cell lung carcinoma and blackwater fever. Among its related pathways are Circadian entrainment and Endocytosis. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF5C.

UniProtKB/Swiss-Prot for KIF5B Gene

  • Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes.

Gene Wiki entry for KIF5B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF5B Gene

Genomics for KIF5B Gene

Regulatory Elements for KIF5B Gene

Enhancers for KIF5B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KIF5B on UCSC Golden Path with GeneCards custom track

Promoters for KIF5B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KIF5B on UCSC Golden Path with GeneCards custom track

Genomic Location for KIF5B Gene

Chromosome:
10
Start:
32,009,010 bp from pter
End:
32,056,443 bp from pter
Size:
47,434 bases
Orientation:
Minus strand

Genomic View for KIF5B Gene

Genes around KIF5B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF5B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF5B Gene

Proteins for KIF5B Gene

  • Protein details for KIF5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P33176-KINH_HUMAN
    Recommended name:
    Kinesin-1 heavy chain
    Protein Accession:
    P33176
    Secondary Accessions:
    • A0AVB2
    • Q5VZ85

    Protein attributes for KIF5B Gene

    Size:
    963 amino acids
    Molecular mass:
    109685 Da
    Quaternary structure:
    • Oligomer composed of two heavy chains and two light chains. Interacts with GRIP1 and PPP1R42 (By similarity). Interacts with SYBU. Interacts with JAKMIP1. Interacts with PLEKHM2. Interacts with ECM29.

    Three dimensional structures from OCA and Proteopedia for KIF5B Gene

neXtProt entry for KIF5B Gene

Proteomics data for KIF5B Gene at MOPED

Post-translational modifications for KIF5B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIF5B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for KIF5B Gene

Domains & Families for KIF5B Gene

Gene Families for KIF5B Gene

Protein Domains for KIF5B Gene

Graphical View of Domain Structure for InterPro Entry

P33176

UniProtKB/Swiss-Prot:

KINH_HUMAN :
  • Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily.
Domain:
  • Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.
  • Contains 1 kinesin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily.
genes like me logo Genes that share domains with KIF5B: view

Function for KIF5B Gene

Molecular function for KIF5B Gene

GENATLAS Biochemistry:
kinesin heavy chain member 5B
UniProtKB/Swiss-Prot Function:
Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes.
genes like me logo Genes that share phenotypes with KIF5B: view

Animal Models for KIF5B Gene

MGI Knock Outs for KIF5B:

Animal Model Products

CRISPR Products

miRNA for KIF5B Gene

miRTarBase miRNAs that target KIF5B

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KIF5B Gene

Localization for KIF5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF5B Gene

Cytoplasm, cytoskeleton. Note=Uniformly distributed between soma and neurites in hippocampal neurons. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIF5B Gene COMPARTMENTS Subcellular localization image for KIF5B gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 3
endoplasmic reticulum 1
endosome 1
golgi apparatus 1
lysosome 1
mitochondrion 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for KIF5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005874 microtubule IEA --
GO:0048471 perinuclear region of cytoplasm IEA,ISS --
genes like me logo Genes that share ontologies with KIF5B: view

Pathways & Interactions for KIF5B Gene

genes like me logo Genes that share pathways with KIF5B: view

Pathways by source for KIF5B Gene

SIGNOR curated interactions for KIF5B Gene

Is activated by:

Gene Ontology (GO) - Biological Process for KIF5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007028 cytoplasm organization IEA --
GO:0007411 axon guidance IBA --
GO:0035617 stress granule disassembly IEA,ISS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with KIF5B: view

Drugs & Compounds for KIF5B Gene

(4) Drugs for KIF5B Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for KIF5B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KIF5B: view

Transcripts for KIF5B Gene

mRNA/cDNA for KIF5B Gene

Unigene Clusters for KIF5B Gene

Kinesin family member 5B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIF5B Gene

No ASD Table

Relevant External Links for KIF5B Gene

GeneLoc Exon Structure for
KIF5B
ECgene alternative splicing isoforms for
KIF5B

Expression for KIF5B Gene

mRNA expression in normal human tissues for KIF5B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KIF5B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.6) and Lymph node (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIF5B Gene



SOURCE GeneReport for Unigene cluster for KIF5B Gene Hs.327736

genes like me logo Genes that share expression patterns with KIF5B: view

Protein tissue co-expression partners for KIF5B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KIF5B Gene

Orthologs for KIF5B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KIF5B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KIF5B 35
  • 94.08 (n)
  • 98.34 (a)
KIF5B 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIF5B 35
  • 94.63 (n)
  • 98.55 (a)
KIF5B 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kif5b 35
  • 90.3 (n)
  • 97.19 (a)
Kif5b 16
Kif5b 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KIF5B 35
  • 99.86 (n)
  • 99.9 (a)
KIF5B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kif5b 35
  • 90.69 (n)
  • 97.3 (a)
oppossum
(Monodelphis domestica)
Mammalia KIF5B 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF5B 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIF5B 35
  • 86.02 (n)
  • 96.98 (a)
KIF5B 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIF5B 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kif5b 35
  • 81.77 (n)
  • 91.13 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24459 35
zebrafish
(Danio rerio)
Actinopterygii kif5ba 35
  • 76.17 (n)
  • 87.16 (a)
wufi31h03 35
kif5ba 36
  • 86 (a)
OneToMany
kif5bb 36
  • 86 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Khc 37
  • 61 (a)
nod 37
  • 36 (a)
Khc 35
  • 58.81 (n)
  • 63.54 (a)
Khc 36
  • 60 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000561 35
  • 58.8 (n)
  • 66.03 (a)
worm
(Caenorhabditis elegans)
Secernentea klp-10 37
  • 28 (a)
klp-18 37
  • 27 (a)
unc-116 37
  • 46 (a)
unc-116 35
  • 58.69 (n)
  • 59.22 (a)
unc-116 36
  • 52 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SMY1 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7717 35
bread mold
(Neurospora crassa)
Ascomycetes NCU09730 35
  • 41.51 (n)
  • 30.86 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 62 (a)
OneToMany
Species with no ortholog for KIF5B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIF5B Gene

ENSEMBL:
Gene Tree for KIF5B (if available)
TreeFam:
Gene Tree for KIF5B (if available)

Paralogs for KIF5B Gene

genes like me logo Genes that share paralogs with KIF5B: view

Variants for KIF5B Gene

Sequence variations from dbSNP and Humsavar for KIF5B Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs13470 -- 32,009,912(-) TTGTA(A/G)TCTGC utr-variant-3-prime
rs1639132 -- 32,012,332(+) TAGGC(A/G)GGCGT intron-variant
rs1639134 -- 32,026,867(+) GGGCC(A/G)AAATG intron-variant
rs1639136 -- 32,033,678(+) TATGA(C/T)TTTTT intron-variant
rs172431 -- 32,037,109(+) CATAA(A/G)GCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF5B Gene

Variant ID Type Subtype PubMed ID
esv2572950 CNV Insertion 19546169
esv1643179 CNV Insertion 17803354
esv2603542 CNV Deletion 19546169

Variation tolerance for KIF5B Gene

Residual Variation Intolerance Score: 6.89% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIF5B Gene

HapMap Linkage Disequilibrium report
KIF5B
Human Gene Mutation Database (HGMD)
KIF5B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF5B Gene

Disorders for KIF5B Gene

MalaCards: The human disease database

(2) MalaCards diseases for KIF5B Gene - From: DISEASES

Disorder Aliases PubMed IDs
adenosquamous cell lung carcinoma
  • adenosquamous lung carcinoma
blackwater fever
  • black water fever
- elite association - COSMIC cancer census association via MalaCards
Search KIF5B in MalaCards View complete list of genes associated with diseases

Relevant External Links for KIF5B

Genetic Association Database (GAD)
KIF5B
Human Genome Epidemiology (HuGE) Navigator
KIF5B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIF5B
genes like me logo Genes that share disorders with KIF5B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIF5B Gene

Publications for KIF5B Gene

  1. Cloning and expression of a human kinesin heavy chain gene: interaction of the COOH-terminal domain with cytoplasmic microtubules in transfected CV-1 cells. (PMID: 1607388) Navone F. … Vale R.D. (J. Cell Biol. 1992) 2 3 4 67
  2. Role of kinesin light chain-2 of kinesin-1 in the traffic of Na,K-ATPase-containing vesicles in alveolar epithelial cells. (PMID: 19773350) Trejo H.E. … Sznajder J.I. (FASEB J. 2010) 3 23
  3. Kinesin-1 plays a role in transport of SNAP-25 to the plasma membrane. (PMID: 19913510) Morton A.M. … Diefenbach R.J. (Biochem. Biophys. Res. Commun. 2010) 3 23
  4. Microtubule-associated protein-like binding of the kinesin-1 tail to microtubules. (PMID: 20071331) Seeger M.A. … Rice S.E. (J. Biol. Chem. 2010) 3 23
  5. RANBP2 is an allosteric activator of the conventional kinesin-1 motor protein, KIF5B, in a minimal cell-free system. (PMID: 19305391) Cho K.I. … Ferreira P.A. (EMBO Rep. 2009) 3 23

Products for KIF5B Gene

Sources for KIF5B Gene

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