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Aliases for KIF5B Gene

Aliases for KIF5B Gene

  • Kinesin Family Member 5B 2 3
  • KNS1 3 4 6
  • UKHC 3 4 6
  • Conventional Kinesin Heavy Chain 3 4
  • Ubiquitous Kinesin Heavy Chain 3 4
  • KNS 3 4
  • Epididymis Secretory Protein Li 61 3
  • Kinesin 1 (110-120kD) 3
  • Kinesin-1 Heavy Chain 3
  • Kinesin Heavy Chain 3
  • HEL-S-61 3
  • KINH 3

External Ids for KIF5B Gene

Previous HGNC Symbols for KIF5B Gene

  • KNS1

Previous GeneCards Identifiers for KIF5B Gene

  • GC10M032448
  • GC10M032304
  • GC10M032340

Summaries for KIF5B Gene

GeneCards Summary for KIF5B Gene

KIF5B (Kinesin Family Member 5B) is a Protein Coding gene. Diseases associated with KIF5B include blackwater fever. Among its related pathways are Class I MHC mediated antigen processing and presentation and Hemostasis. GO annotations related to this gene include microtubule binding and microtubule motor activity. An important paralog of this gene is KIF5C.

UniProtKB/Swiss-Prot for KIF5B Gene

  • Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes.

Gene Wiki entry for KIF5B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF5B Gene

Genomics for KIF5B Gene

Regulatory Elements for KIF5B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KIF5B Gene

32,009,010 bp from pter
32,056,443 bp from pter
47,434 bases
Minus strand

Genomic View for KIF5B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIF5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF5B Gene

Proteins for KIF5B Gene

  • Protein details for KIF5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kinesin-1 heavy chain
    Protein Accession:
    Secondary Accessions:
    • A0AVB2
    • Q5VZ85

    Protein attributes for KIF5B Gene

    963 amino acids
    Molecular mass:
    109685 Da
    Quaternary structure:
    • Oligomer composed of two heavy chains and two light chains. Interacts with GRIP1 and PPP1R42 (By similarity). Interacts with SYBU. Interacts with JAKMIP1. Interacts with PLEKHM2. Interacts with ECM29.

    Three dimensional structures from OCA and Proteopedia for KIF5B Gene

neXtProt entry for KIF5B Gene

Proteomics data for KIF5B Gene at MOPED

Post-translational modifications for KIF5B Gene

  • Ubiquitination at Lys10
  • Modification sites at PhosphoSitePlus

Other Protein References for KIF5B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KIF5B Gene

Domains for KIF5B Gene

Gene Families for KIF5B Gene

  • KIF :Kinesins

Protein Domains for KIF5B Gene

Graphical View of Domain Structure for InterPro Entry



  • P33176
  • Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles
  • Contains 1 kinesin motor domain.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily.
genes like me logo Genes that share domains with KIF5B: view

Function for KIF5B Gene

Molecular function for KIF5B Gene

GENATLAS Biochemistry:
kinesin heavy chain member 5B
UniProtKB/Swiss-Prot Function:
Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes.

Gene Ontology (GO) - Molecular Function for KIF5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity ISS --
GO:0005515 protein binding IPI 19164528
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding ISS --
GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed IBA --
genes like me logo Genes that share ontologies with KIF5B: view
genes like me logo Genes that share phenotypes with KIF5B: view

Animal Models for KIF5B Gene

MGI Knock Outs for KIF5B:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIF5B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for KIF5B Gene

Localization for KIF5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF5B Gene

Cytoplasm, cytoskeleton. Note=Uniformly distributed between soma and neurites in hippocampal neurons. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for KIF5B Gene COMPARTMENTS Subcellular localization image for KIF5B gene
Compartment Confidence
cytoskeleton 4
cytosol 3
nucleus 2
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for KIF5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005815 microtubule organizing center IDA --
GO:0005871 kinesin complex IBA --
GO:0005874 microtubule IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with KIF5B: view

Pathways for KIF5B Gene

genes like me logo Genes that share pathways with KIF5B: view

Pathways by source for KIF5B Gene

1 KEGG pathway for KIF5B Gene
1 GeneGo (Thomson Reuters) pathway for KIF5B Gene

Gene Ontology (GO) - Biological Process for KIF5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0007018 microtubule-based movement IBA --
GO:0007028 cytoplasm organization IEA --
GO:0007411 axon guidance IBA --
GO:0030705 cytoskeleton-dependent intracellular transport IBA --
genes like me logo Genes that share ontologies with KIF5B: view

Compounds for KIF5B Gene

(1) Drugbank Compounds for KIF5B Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
20398-34-9 target

(6) Novoseek inferred chemical compound relationships for KIF5B Gene

Compound -log(P) Hits PubMed IDs
amp-pnp 55.1 1
atp 54.1 15
adp 41.6 5
nocodazole 26.5 1
lipid 0 1
genes like me logo Genes that share compounds with KIF5B: view

Transcripts for KIF5B Gene

mRNA/cDNA for KIF5B Gene

(485) Selected AceView cDNA sequences:
(20) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KIF5B Gene

Kinesin family member 5B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIF5B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF5B Gene

No ASD Table

Relevant External Links for KIF5B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KIF5B Gene

mRNA expression in normal human tissues for KIF5B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for KIF5B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.6) and Lymph node (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIF5B Gene

SOURCE GeneReport for Unigene cluster for KIF5B Gene Hs.327736

genes like me logo Genes that share expressions with KIF5B: view

Expression partners for KIF5B Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KIF5B Gene

Orthologs for KIF5B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KIF5B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KIF5B 35
  • 94.08 (n)
  • 98.34 (a)
KIF5B 36
  • 98 (a)
(Canis familiaris)
Mammalia KIF5B 35
  • 94.63 (n)
  • 98.55 (a)
KIF5B 36
  • 99 (a)
(Mus musculus)
Mammalia Kif5b 35
  • 90.3 (n)
  • 97.19 (a)
Kif5b 16
Kif5b 36
  • 97 (a)
(Pan troglodytes)
Mammalia KIF5B 35
  • 99.86 (n)
  • 99.9 (a)
KIF5B 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Kif5b 35
  • 90.69 (n)
  • 97.3 (a)
(Monodelphis domestica)
Mammalia KIF5B 36
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia KIF5B 36
  • 97 (a)
(Gallus gallus)
Aves KIF5B 35
  • 86.02 (n)
  • 96.98 (a)
KIF5B 36
  • 97 (a)
(Anolis carolinensis)
Reptilia KIF5B 36
  • 95 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kif5b 35
  • 81.77 (n)
  • 91.13 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24459 35
(Danio rerio)
Actinopterygii kif5ba 35
  • 76.17 (n)
  • 87.16 (a)
wufi31h03 35
kif5ba 36
  • 86 (a)
kif5bb 36
  • 86 (a)
fruit fly
(Drosophila melanogaster)
Insecta Khc 37
  • 61 (a)
nod 37
  • 36 (a)
Khc 35
  • 58.81 (n)
  • 63.54 (a)
Khc 36
  • 60 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000561 35
  • 58.8 (n)
  • 66.03 (a)
(Caenorhabditis elegans)
Secernentea klp-10 37
  • 28 (a)
klp-18 37
  • 27 (a)
unc-116 37
  • 46 (a)
unc-116 35
  • 58.69 (n)
  • 59.22 (a)
unc-116 36
  • 52 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SMY1 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7717 35
bread mold
(Neurospora crassa)
Ascomycetes NCU09730 35
  • 41.51 (n)
  • 30.86 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 62 (a)
Species with no ortholog for KIF5B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIF5B Gene

Gene Tree for KIF5B (if available)
Gene Tree for KIF5B (if available)

Paralogs for KIF5B Gene

genes like me logo Genes that share paralogs with KIF5B: view

Variants for KIF5B Gene

Sequence variations from dbSNP and Humsavar for KIF5B Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs13470 -- 32,009,912(-) TTGTA(A/G)TCTGC utr-variant-3-prime
rs172431 -- 32,037,109(+) CATAA(A/G)GCACT intron-variant
rs172432 -- 32,014,830(+) ACAAG(A/G)AGATG intron-variant
rs176924 -- 32,023,041(+) GCTGT(A/G)AGGAA intron-variant
rs188402 -- 32,016,253(+) GGAGT(A/T)CGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF5B Gene

Variant ID Type Subtype PubMed ID
esv2572950 CNV Insertion 19546169
esv1643179 CNV Insertion 17803354
esv2603542 CNV Deletion 19546169

Relevant External Links for KIF5B Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF5B Gene

Disorders for KIF5B Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for KIF5B Gene in MalaCards »

(1) Diseases for KIF5B Gene including...

(2) University of Copenhagen DISEASES for KIF5B Gene

Relevant External Links for KIF5B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with KIF5B: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for KIF5B Gene

Publications for KIF5B Gene

  1. Cloning and expression of a human kinesin heavy chain gene: interaction of the COOH-terminal domain with cytoplasmic microtubules in transfected CV-1 cells. (PMID: 1607388) Navone F. … Vale R.D. (J. Cell Biol. 1992) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  3. Microtubule-associated protein-like binding of the kinesin-1 tail to microtubules. (PMID: 20071331) Seeger M.A. … Rice S.E. (J. Biol. Chem. 2010) 3 23
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48
  5. Role of kinesin light chain-2 of kinesin-1 in the traffic of Na,K-ATPase-containing vesicles in alveolar epithelial cells. (PMID: 19773350) Trejo H.E. … Sznajder J.I. (FASEB J. 2010) 3 23

Products for KIF5B Gene

  • Addgene plasmids for KIF5B

Sources for KIF5B Gene

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