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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KIF5B Gene

protein-coding   GIFtS: 67
GCID: GC10M032340

Kinesin Family Member 5B


(Previous symbol: KNS1)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Kinesin Family Member 5B1 2     KNS2 3
KNS11 2 3 5     KINH2
UKHC2 3 5     Kinesin 1 (110-120kD)2
Conventional Kinesin Heavy Chain2 3     Kinesin Heavy Chain2
Ubiquitous Kinesin Heavy Chain2 3     Kinesin-1 Heavy Chain2

External Ids:    HGNC: 63241   Entrez Gene: 37992   Ensembl: ENSG000001707597   OMIM: 6028095   UniProtKB: P331763   

Export aliases for KIF5B gene to outside databases

Previous GC identifers: GC10M032035 GC10M032448 GC10M032304


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for KIF5B Gene: 
KIF5B (kinesin family member 5B) is a protein-coding gene. Diseases associated with KIF5B include blackwater fever, and vaccinia, and among its related super-pathways are Cytoskeleton remodeling Neurofilaments and Immune System. GO annotations related to this gene include microtubule binding and microtubule motor activity. An important paralog of this gene is KIF3A.

UniProtKB/Swiss-Prot: KINH_HUMAN, P33176
Function: Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes (By
similarity)

Gene Wiki entry for KIF5B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_008705.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KIF5B gene promoter:
         Nkx3-1   Elk-1   Nkx3-1 v4   Nkx3-1 v1   NF-kappaB   Evi-1   Nkx3-1 v2   COMP1   Nkx3-1 v3   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKIF5B promoter sequence
   Search SABiosciences Chromatin IP Primers for KIF5B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIF5B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p11.22   Ensembl cytogenetic band:  10p11.22   HGNC cytogenetic band: 10p11.22

KIF5B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIF5B gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M032340:  view genomic region     (about GC identifiers)

Start:
32,297,938 bp from pter      End:
32,345,371 bp from pter
Size:
47,434 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KINH_HUMAN, P33176 (See protein sequence)
Recommended Name: Kinesin-1 heavy chain  
Size: 963 amino acids; 109685 Da
Subunit: Oligomer composed of two heavy chains and two light chains. Interacts with GRIP1 and PPP1R42 (By
similarity). Interacts with SYBU. Interacts with JAKMIP1. Interacts with PLEKHM2. Interacts with ECM29
Subcellular location: Cytoplasm, cytoskeleton (By similarity). Note=Uniformly distributed between soma and
neurites in hippocampal neurons (By similarity)
4 PDB 3D structures from and Proteopedia for KIF5B:
1BG2 (3D)        1MKJ (3D)        2P4N (3D)        4HNA (3D)    
Secondary accessions: A0AVB2 Q5VZ85

Explore the universe of human proteins at neXtProt for KIF5B: NX_P33176

Explore proteomics data for KIF5B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P33176

  • KIF5B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KIF5B Protein Expression
    REFSEQ proteins: NP_004512.1  
    ENSEMBL proteins: 
     ENSP00000307078  
    Reactome Protein details: P33176
    Human Recombinant Protein Products for KIF5B: 
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    Cloud-Clone Corp. Proteins for KIF5B 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005871kinesin complex IEA--
    GO:0005874microtubule IEA--
    GO:0031982vesicle IDA--
    GO:0035253ciliary rootlet IEA--

    KIF5B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    KIF: Kinesins

    3 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR001752 Kinesin_motor_dom
     IPR019821 Kinesin_motor_CS

    Graphical View of Domain Structure for InterPro Entry P33176

    ProtoNet protein and cluster: P33176

    1 Blocks protein domain: IPB001752 Kinesin

    UniProtKB/Swiss-Prot: KINH_HUMAN, P33176
    Domain: Composed of three structural domains: a large globular N-terminal domain which is responsible for the
    motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain
    that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other
    proteins (such as the kinesin light chains), vesicles and membranous organelles
    Similarity: Belongs to the kinesin-like protein family. Kinesin subfamily
    Similarity: Contains 1 kinesin-motor domain


    KIF5B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KINH_HUMAN, P33176
    Function: Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes (By
    similarity)

         Genatlas biochemistry entry for KIF5B:
    kinesin heavy chain member 5B

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003777microtubule motor activity ISS--
    GO:0005515protein binding IPI19164528
    GO:0005524ATP binding IEA--
    GO:0008017microtubule binding ISS--
         
    KIF5B for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for KIF5B:
     Decreased viability after Chla  G0/1 arrest  Increased G1 DNA content 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Kif5b):
     cellular  embryogenesis  endocrine/exocrine gland  growth/size  homeostasis/metabolism 
     mortality/aging 

    KIF5B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Kif5btm1Noh for KIF5B

       inGenious Targeting Laboratory - Custom generated mouse model solutions for KIF5B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KIF5B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KIF5B 
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    miRNA
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KIF5B About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cytoskeleton remodeling Neurofilaments
    Cytoskeleton remodeling Neurofilaments0.91
    Cytoplasmic microtubules0.32
    2Immune System
    Immune System0.56
    Adaptive Immune System0.56
    3MHC class II antigen presentation
    MHC class II antigen presentation0.32
    Kinesins0.32
    4Platelet activation, signaling and aggregation
    Hemostasis0.43
    5Insulin Processing
    Peptide hormone metabolism0.39
    Insulin Processing0.39

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for KIF5B
        Cytoskeleton remodeling Neurofilaments
    Cytoplasmic microtubules


    1 GeneGo (Thomson Reuters) Pathway for KIF5B
        Cytoskeleton remodeling Neurofilaments

    2 BioSystems Pathways for KIF5B
        Insulin Signaling
    N-cadherin signaling events

    5/9        Reactome Pathways for KIF5B (see all 9)
        Hemostasis
    Insulin Processing
    Adaptive Immune System
    Factors involved in megakaryocyte development and platelet production
    Metabolism of proteins


    1         Kegg Pathway  (Kegg details for KIF5B):
        Dopaminergic synapse


    KIF5B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KIF5B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/107 Interacting proteins for KIF5B (P331762, 3 ENSP000003070784) via UniProtKB, MINT, STRING, and/or I2D (see all 107)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHABP319462, 3, ENSP000003001614MINT-50950 I2D: score=5 STRING: ENSP00000300161
    YWHAGP619812, 3, ENSP000003063304MINT-50811 I2D: score=4 STRING: ENSP00000306330
    GSK3BP498412, 3, ENSP000003248064MINT-8257394 I2D: score=2 STRING: ENSP00000324806
    RANBP2P497922, 3, ENSP000002831954MINT-7289062 I2D: score=1 STRING: ENSP00000283195
    IKBKGQ9Y6K92, 3MINT-48157 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007018microtubule-based movement TAS7514426
    GO:0007028cytoplasm organization IEA--
    GO:0035617stress granule disassembly ISS--
    GO:0042391regulation of membrane potential IDA19675065
    GO:0043268positive regulation of potassium ion transport IDA19675065

    KIF5B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KIF5B for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KIF5B (KINH)

    1 DrugBank Compound for KIF5B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine-5'-Diphosphate-- 20398-34-9target--10592235

    6 Novoseek inferred chemical compound relationships for KIF5B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    amp-pnp 55.1 2 17412962 (1)
    atp 54.1 21 17412962 (3), 18948105 (2), 16361092 (2), 19236100 (1) (see all 11)
    adp 41.6 7 18578509 (2), 17412962 (1), 18037705 (1), 18579780 (1)
    nocodazole 26.5 1 11807097 (1)
    lipid 0 1 19070567 (1)
    tyrosine 0 1 16450053 (1)

    Search CenterWatch for drugs/clinical trials and news about KIF5B / KINH

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KIF5B gene: 
    NM_004521.2  

    Unigene Cluster for KIF5B:

    Kinesin family member 5B
    Hs.327736  [show with all ESTs]
    Unigene Representative Sequence: NM_004521
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000302418(uc001iwe.4) ENST00000493889

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    Additional mRNA sequence: 

    AB795238.1 AB795249.1 AB795250.1 AB795251.1 AB795252.1 AB795253.1 AB795254.1 AB795255.1 
    AB795256.1 AB795257.1 AK289413.1 AK299542.1 AK307502.1 BC010885.1 BC065267.1 BC080604.1 
    BC111042.1 BC126279.1 BC126281.1 X65873.1 

    19 DOTS entries:

    DT.99982067  DT.452170  DT.92453969  DT.86843237  DT.92453972  DT.121292873  DT.95264092  DT.80100445 
    DT.95264082  DT.92453971  DT.65284307  DT.121292829  DT.121292840  DT.92011075  DT.92453957  DT.95197629 
    DT.95264080  DT.95249472  DT.99963731 

    24/485 AceView cDNA sequences (see all 485):

    AA789155 AW273034 AV725355 AA403137 AI924260 AA608669 AA565936 BX281720 
    BC080604 CA310879 BE018590 AI367065 AL046773 CN479986 AA370731 BM667546 
    CB158971 AI342375 BG059349 BF436514 BQ420677 BU183384 AW050461 BC065267 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KIF5B expression in normal human tissues (normalized intensities)      KIF5B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTAAATGC
    KIF5B Expression
    About this image


    KIF5B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/20 selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Thalamus
             ganglion/cranial   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Retina
             sensory organ/eye/cornea   
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             heart/atrium   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi

    See KIF5B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KIF5B

    SOURCE GeneReport for Unigene cluster: Hs.327736
        SABiosciences Custom PCR Arrays for KIF5B
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for KIF5B gene from 8/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kif5b1 , 5 kinesin family member 5B1, 5 90.3(n)1
    97.19(a)1
      18 (4.46 cM)5
    165731  NM_008448.31  NP_032474.21 
     62010025 
    chicken
    (Gallus gallus)
    Aves KIF5B1 kinesin family member 5B 86.04(n)
    96.99(a)
      420472  XM_418574.3  XP_418574.1 
    lizard
    (Anolis carolinensis)
    Reptilia KIF5B6
    Uncharacterized protein
    95(a)
    1 ↔ 1
    6(12561846-12592253)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.244592 Xenopus laevis transcribed sequence with moderate similarity more 78.81(n)    CD301649.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi31h032 wufi31h03 76.11(n)   334108  BI706860.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Khc1 , 3 microtubule-based movement microtubule
    binding3
    Kinesin heavy chain1
    61(a)
    (best of 2)3
    58.74(n)1
    63.33(a)1
      368101  NM_057242.41  NP_476590.11 
    worm
    (Caenorhabditis elegans)
    Secernentea unc-1161 , 3 Kinesin heavy chain3
    Protein UNC-1161
    46(a)
    (best of 3)3
    53.82(n)1
    48.02(a)1
      III(8423542-8426830)3
    1761791  NM_066441.51  NP_498842.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SMY1(YKL079W)4 Protein that interacts with Myo2p, proposed to be involved more   --   11(286603-288573) 853783  NP_012844.1 


    ENSEMBL Gene Tree for KIF5B (if available)
    TreeFam Gene Tree for KIF5B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KIF5B gene
    KIF3A2  KIF5C2  KIF1C2  KIF112  KIF16B2  KIF3B2  KIF1B2  KIF142  
    KIF13B2  KIF1A2  KIF172  KIF13A2  CENPE2  KIF152  KIF5A2  KIF3C2  
    18/40 SIMAP similar genes for KIF5B using alignment to 5 protein entries:     KINH_HUMAN (see all proteins) (see all similar genes):
    KIF5B-ALK    R11    A20    R12    KIF5C    DKFZp566O183
    KIF5A    Nbla04137    KIF18B    KIF9    CENPE    KIFC3
    KIF13B    KIF1A    KIF1Bbeta    KIF13A    KIF3A    KIF3C

    KIF5B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1066 SNPs in KIF5B are shown (see all 1066)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1488631021,2
    C--32297438(+) CGGTCA/GGGTGC 1 -- ds50010--------
    rs122403921,2
    C,F,A,H--32297802(+) TCTGCG/AGTCCA 1 -- ds50014Minor allele frequency- A:0.00NS EA 418
    rs1434089291,2
    C--32297844(+) ACATA-/AATAT 
            
    AATGA
    1 -- ds50010--------
    rs1140560561,2
    C,F--32297954(+) AAAATT/GTTCCT 1 -- ut311Minor allele frequency- G:0.03WA 118
    rs1434944051,2
    --32297956(+) AATTTG/TCCTCT 1 -- ut310--------
    rs727751841,2
    --32298093(+) ACTCAC/GACTCT 1 -- ut310--------
    rs1921849851,2
    --32298530(+) ACACAA/GCACCA 1 -- ut310--------
    rs2021309861,2
    --32298587(+) AAGAG-/AAAAAA 1 -- ut310--------
    rs134701,2
    C,F,H--32298840(-) TTGTAA/GTCTGC 1 -- ut31 ese324Minor allele frequency- T:0.01NA MN NS EA CSA WA 2337
    rs1385024951,2
    --32298883(+) TAAATA/TAATTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KIF5B (32297938 - 32345371 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KIF5B:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2603542CNV Deletion19546169
    esv1643179CNV Insertion17803354
    esv2572950CNV Insertion19546169


    Human Gene Mutation Database (HGMD): KIF5B
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KIF5B
    DNA2.0 Custom Variant and Variant Library Synthesis for KIF5B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602809    OMIM disorders: --

    12 diseases for KIF5B:    About MalaCards
    blackwater fever    vaccinia    neurofibromatosis    herpes simplex
    lung adenocarcinoma    mental retardation    schizophrenia    alzheimer's disease
    prostate cancer    neuronitis    adenocarcinoma    prostatitis

    2 diseases from the University of Copenhagen DISEASES database for KIF5B:
    Blackwater fever     Lung cancer

    KIF5B for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): KIF5B
    Human Genome Epidemiology (HuGE) Navigator: KIF5B (2 documents)

    Export disorders for KIF5B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KIF5B gene, integrated from 9 sources (see all 176):
    (articles sorted by number of sources associating them with KIF5B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of a human kinesin heavy chain gene: interaction of the COOH-terminal domain with cytoplasmic microtubules in transfected CV-1 cells. (PubMed id 1607388)1, 2, 3 Navone F.... Vale R.D. (1992)
    2. A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. (PubMed id 20682791)1, 2 Gorbea C.... Rechsteiner M. (2010)
    3. KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise. (PubMed id 18984674)1, 4 Argyropoulos G....Rankinen T. (2009)
    4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    5. The intracellular fate of Salmonella depends on the recruitment of kinesin. (PubMed id 15905402)1, 2 Boucrot E.... Meresse S. (2005)
    6. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    7. Syntabulin is a microtubule-associated protein implicated in syntaxin transport in neurons. (PubMed id 15459722)1, 2 Su Q.... Sheng Z.-H. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Crystal structure of the kinesin motor domain reveals a structural similarity to myosin. (PubMed id 8606779)1, 2 Kull F.J.... Vale R.D. (1996)
    10. The kinesin-1 motor protein is regulated by a direct interaction of its head and tail. (PubMed id 18579780)1, 9 Dietrich K.A....Rice S.E. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3799 HGNC: 6324 AceView: KIF5B Ensembl:ENSG00000170759 euGenes: HUgn3799
    ECgene: KIF5B Kegg: 3799 H-InvDB: KIF5B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KIF5B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KIF5B gene:
    Search GeneIP for patents involving KIF5B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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