Aliases for KIF5A Gene
External Ids for KIF5A Gene
Previous HGNC Symbols for KIF5A Gene
Previous GeneCards Identifiers for KIF5A Gene
This gene encodes a member of the kinesin family of proteins. Members of this family are part of a multisubunit complex that functions as a microtubule motor in intracellular organelle transport. Mutations in this gene cause autosomal dominant spastic paraplegia 10. [provided by RefSeq, Jul 2008]
GeneCards Summary for KIF5A Gene
KIF5A (Kinesin Family Member 5A) is a Protein Coding gene. Diseases associated with KIF5A include Spastic Paraplegia 10, Autosomal Dominant and Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Kif5a Mutation. Among its related pathways are Innate Immune System and Golgi-to-ER retrograde transport. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF5C.
UniProtKB/Swiss-Prot for KIF5A Gene
Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons.