KIF4B Gene
protein-coding GIFtS: 43
GCID: GC05P154393
|
|
kinesin family member 4B
| |
Aliases
for KIF4B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Kinesin Family Member 4B1 2 | | Chromokinesin-B3 | | Chromosome-Associated Kinesin KIF4B2 | | Chromokinesin-B3 |
Export aliases for KIF4B gene to outside databasesPrevious GC identifers: GC05U990137 GC05P154374 GC05P149535 |
Summaries
for KIF4B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: KIF4B_HUMAN, Q2VIQ3Function: Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during themetaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone andmidbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindlestabilization (By similarity)
|
Genomic Views
for KIF4B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_029289.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KIF4B gene promoter:
NF-1 NF-1/L GATA-3 Brachyury MyoD HNF-3beta GATA-2 GATA-1 C/EBPalpha Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for KIF4B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIF4B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q33.1 Ensembl cytogenetic band: 5q33.2 HGNC cytogenetic band: 5q33.2KIF4B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P154393: view genomic region
(about GC identifiers)
Start:
|
154,393,260 bp from pter |
End:
|
154,397,692 bp from pter |
Size:
|
4,433 bases |
Orientation:
|
plus strand |
|
Proteins
for KIF4B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KIF4B_HUMAN, Q2VIQ3 (See
protein sequence)Recommended Name: Chromosome-associated kinesin KIF4B Size: 1234 amino acids; 140035 Da
Subcellular location: Nucleus matrix (By similarity). Cytoplasm, cytoskeleton (Probable)Explore the universe of human proteins at neXtProt for KIF4B: NX_Q2VIQ3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q2VIQ3
KIF4B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001092763.1
ENSEMBL proteins: ENSP00000387875 Reactome Protein details: Q2VIQ3
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
KIF4B for ontologies About GeneDecksing
KIF4B Antibody Products:
Assay Products for KIF4B: |
Protein
Domains /
Families
for KIF4B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KIF4B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q2VIQ3ProtoNet protein and cluster: Q2VIQ3 UniProtKB/Swiss-Prot: KIF4B_HUMAN, Q2VIQ3Similarity: Belongs to the kinesin-like protein family. Chromokinesin subfamilySimilarity: Contains 1 kinesin-motor domain |
Function
for KIF4B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KIF4B_HUMAN, Q2VIQ3Function: Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during themetaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone andmidbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindlestabilization (By similarity)
Clone
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF4B |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
KIF4B for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for KIF4B:
|
Pathways & Interactions
for KIF4B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Axon guidance | | | 2 | Immune System | | | 3 | Kinesins | | | 4 | MHC class II antigen presentation | | | 5 | Factors involved in megakaryocyte development and platelet production | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/12 
Reactome Pathways for KIF4B (see all 12)
KIF4B for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIF4B
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for KIF4B (Q2VIQ33 ENSP000003878754) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007018 | microtubule-based movement |
TAS | -- | | GO:0007411 | axon guidance |
TAS | -- | | GO:0007596 | blood coagulation |
TAS | -- | | GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II |
TAS | -- |
KIF4B for ontologies About GeneDecksing
|
Drugs & Compounds
for KIF4B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KIF4B
Search CenterWatch for drugs/clinical trials and news about KIF4B
|
Transcripts
for KIF4B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KIF4B gene: NM_001099293.1 Unigene Cluster for KIF4B: Kinesin family member 4B Hs.567824 [show with all ESTs]Unigene Representative Sequence: NM_0010992931 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000435029(uc010jih.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIF4B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIF4B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KIF4B (NM_001099293) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KIF4B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIF4B |
Additional cDNA sequence: AK302388.1 5 DOTS entries: DT.120852914 DT.100779924 DT.100779925 DT.452160 DT.99928543 1 AceView cDNA sequence: BI259443
GeneLoc Exon Structure
|
Expression
for KIF4B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KIF4B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGTTGAAGT
About this image
See KIF4B Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.567824
UniProtKB/Swiss-Prot: KIF4B_HUMAN, Q2VIQ3Tissue specificity: Specifically expressed in testis
SABiosciences Custom PCR Arrays for KIF4B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIF4B
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF4B |
Orthologs
for KIF4B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for KIF4B gene from 7/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
F1P1M8_CHICK6 |
kinesin family member 4A |
73(a) |
1 → many |
4(1250810-1267876) |
lizard
(Anolis carolinensis) |
Reptilia |
----(see all 3) |
-- |
7(a)65(a)(see all 3) |
possible orthologmany ↔ many(see all 3) |
5(98775181-98827158) GL343400.1(368365-390625) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.35092 |
Transcribed sequence with moderate similarity to protein more |
80.19(n) |
|
142026585 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc:661256 |
zgc:66125 |
60(a) |
1 → many |
21(43273690-43308834) |
fruit fly
(Drosophila melanogaster) |
Insecta |
Klp3A6 |
Kinesin-like protein at 3A |
26(a) |
1 → many |
X(2493190-2498085) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT5G609301 |
kinesin family member 4/7/21/27 |
48.77(n)
37.75(a) |
|
836214 NM_125486.2 NP_200901.2 |
rice
(Oryza sativa) |
Liliopsida |
-- |
kinesin motor domain containing protein, putative,... |
30(a) |
1 → many |
9(1157082-1166873) |
Species with no ortholog for KIF4B
ENSEMBL Gene Tree for KIF4B (if available)
TreeFam Gene Tree for KIF4B (if available) |
Paralogs
for KIF4B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KIF4B gene
- KIF5C2 KIF21A2 KIF112 KIF3B2 KIF21B2 KIF92 KIF172 KIF272
- KIF3A2 KIF4A2 KIF5B2 KIF62 KIF152 CENPE2 KIF5A2 KIF72
- KIF3C2
1 SIMAP similar gene for KIF4B using alignment to 1 protein entry: KIF4B_HUMAN:KIF4A
KIF4B for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for KIF4B
PGOHUM00000241868
|
Genomic Variants
for KIF4B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KIF4B (154393260 - 154397692 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for KIF4B
1 CNV: 69228 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIF4B |
|
Disorders
/ Diseases
for KIF4B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KIF4B for disorders About GeneDecksing
OMIM gene information: 609184
OMIM disorders: --
2  diseases for KIF4B: About MalaCardsbasal cell carcinoma carcinoma
Export disorders for KIF4B gene to outside databases
|
Publications
for KIF4B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KIF4B gene integrated from 9 sources:
(articles sorted by number of sources associating them with KIF4B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Emergence of young human genes after a burst of retroposition in primates. (PubMed id 16201836)1, 2 Marques A.C.... Kaessmann H. (2005)
- Identification of the human homologue of mouse KIF4, a kinesin superfamily motor protein. (PubMed id 10978527)1, 2 Oh S.J.... Kim W. (2000)
- System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (2009)
- Kinesin KIF4 regulates intracellular trafficking and stability of the human immunodeficiency virus type 1 Gag polyprotein. (PubMed id 18684836)1 Martinez N.W....Resh M.D. (2008)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (2004)
- Assignment of the kinesin family member 4 genes (KIF4A and KIF4B) to human chromosome bands Xq13.1 and 5q33.1 by in situ hybridization. (PubMed id 10773663)1 Ha M.J....Kim W. (2000)
- Cellular motor protein KIF-4 associates with retroviral Gag. (PubMed id 10559369)1 Tang Y....Morse H.C. (1999)
|
External Searches for KIF4B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KIF4B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KIF4B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KIF4B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KIF4B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KIF4B gene:
Search GeneIP for patents involving KIF4B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KIF4B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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