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Aliases for KIF4B Gene

Aliases for KIF4B Gene

  • Kinesin Family Member 4B 2 3
  • Chromokinesin-B 3 4
  • Chromosome-Associated Kinesin KIF4B 3

External Ids for KIF4B Gene

Previous GeneCards Identifiers for KIF4B Gene

  • GC05U990137
  • GC05P154374
  • GC05P154393
  • GC05P149535

Summaries for KIF4B Gene

GeneCards Summary for KIF4B Gene

KIF4B (Kinesin Family Member 4B) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and L1CAM interactions. GO annotations related to this gene include microtubule binding and microtubule motor activity. An important paralog of this gene is KIF5C.

UniProtKB/Swiss-Prot for KIF4B Gene

  • Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF4B Gene

Genomics for KIF4B Gene

Regulatory Elements for KIF4B Gene

Genomic Location for KIF4B Gene

Start:
155,013,700 bp from pter
End:
155,018,132 bp from pter
Size:
4,433 bases
Orientation:
Plus strand

Genomic View for KIF4B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIF4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF4B Gene

Proteins for KIF4B Gene

  • Protein details for KIF4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2VIQ3-KIF4B_HUMAN
    Recommended name:
    Chromosome-associated kinesin KIF4B
    Protein Accession:
    Q2VIQ3
    Secondary Accessions:

    Protein attributes for KIF4B Gene

    Size:
    1234 amino acids
    Molecular mass:
    140035 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KIF4B Gene

Proteomics data for KIF4B Gene at MOPED

Post-translational modifications for KIF4B Gene

  • Ubiquitination at Lys840
  • Modification sites at PhosphoSitePlus

Other Protein References for KIF4B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KIF4B Gene

Domains for KIF4B Gene

Gene Families for KIF4B Gene

HGNC:
  • KIF :Kinesins

Protein Domains for KIF4B Gene

Suggested Antigen Peptide Sequences for KIF4B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2VIQ3

UniProtKB/Swiss-Prot:

KIF4B_HUMAN :
  • Q2VIQ3
Domain:
  • Contains 1 kinesin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Chromokinesin subfamily.
genes like me logo Genes that share domains with KIF4B: view

Function for KIF4B Gene

Molecular function for KIF4B Gene

UniProtKB/Swiss-Prot Function: Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity).

Gene Ontology (GO) - Molecular Function for KIF4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003777 microtubule motor activity --
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed IBA --
genes like me logo Genes that share ontologies with KIF4B: view

Phenotypes for KIF4B Gene

GenomeRNAi human phenotypes for KIF4B:
genes like me logo Genes that share phenotypes with KIF4B: view

Animal Model Products

CRISPR Products

miRNA for KIF4B Gene

miRTarBase miRNAs that target KIF4B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIF4B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KIF4B Gene

Localization for KIF4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF4B Gene

Nucleus matrix. Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIF4B Gene COMPARTMENTS Subcellular localization image for KIF4B gene
Compartment Confidence
cytoskeleton 4
cytosol 4
nucleus 4

Gene Ontology (GO) - Cellular Components for KIF4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005871 kinesin complex IBA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with KIF4B: view

Pathways for KIF4B Gene

genes like me logo Genes that share pathways with KIF4B: view

Pathways by source for KIF4B Gene

Interacting Proteins for KIF4B Gene

Gene Ontology (GO) - Biological Process for KIF4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000281 mitotic cytokinesis IMP 15843429
GO:0006200 obsolete ATP catabolic process --
GO:0007018 microtubule-based movement TAS --
GO:0007411 axon guidance TAS --
GO:0007596 blood coagulation TAS --
genes like me logo Genes that share ontologies with KIF4B: view

Transcripts for KIF4B Gene

mRNA/cDNA for KIF4B Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KIF4B Gene

Kinesin family member 4B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIF4B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KIF4B
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF4B Gene

No ASD Table

Relevant External Links for KIF4B Gene

GeneLoc Exon Structure for
KIF4B
ECgene alternative splicing isoforms for
KIF4B

Expression for KIF4B Gene

mRNA expression in normal human tissues for KIF4B Gene

mRNA differential expression in normal tissues according to GTEx for KIF4B Gene

This gene is overexpressed in Testis (40.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KIF4B Gene

SOURCE GeneReport for Unigene cluster for KIF4B Gene Hs.567824

mRNA Expression by UniProt/SwissProt for KIF4B Gene

Q2VIQ3-KIF4B_HUMAN
Tissue specificity: Specifically expressed in testis.
genes like me logo Genes that share expressions with KIF4B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for KIF4B Gene

Orthologs for KIF4B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KIF4B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF4B 35
  • 99.11 (n)
  • 98.7 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 89 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 91 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Kif4 36
  • 84 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 78 (a)
OneToMany
chicken
(Gallus gallus)
Aves KIF4A 36
  • 73 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 57 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3509 35
zebrafish
(Danio rerio)
Actinopterygii KIF4A 36
  • 60 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Klp3A 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea klp-19 36
  • 32 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons FRA1 35
  • 47.53 (n)
  • 41.04 (a)
rice
(Oryza sativa)
Liliopsida Os09g0114500 35
  • 49.88 (n)
  • 42.12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToMany
Species with no ortholog for KIF4B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIF4B Gene

ENSEMBL:
Gene Tree for KIF4B (if available)
TreeFam:
Gene Tree for KIF4B (if available)

Paralogs for KIF4B Gene

Selected SIMAP similar genes for KIF4B Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for KIF4B Gene

genes like me logo Genes that share paralogs with KIF4B: view

Variants for KIF4B Gene

Sequence variations from dbSNP and Humsavar for KIF4B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs2453755 -- 155,013,086(+) attgg(C/T)ctatt upstream-variant-2KB
rs6580126 - 155,015,598(+) GGTTC(G/T)TGAAC reference, missense
rs6859994 -- 155,013,256(+) tttgt(C/T)aatat upstream-variant-2KB
rs7721346 -- 155,013,384(+) tccat(C/T)tattt upstream-variant-2KB
rs10056252 - 155,015,910(+) GCAAT(A/G)TGAGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for KIF4B Gene

Variant ID Type Subtype PubMed ID
nsv883058 CNV Gain 21882294
esv21446 CNV Gain 19812545

Relevant External Links for KIF4B Gene

HapMap Linkage Disequilibrium report
KIF4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF4B Gene

Disorders for KIF4B Gene

Relevant External Links for KIF4B

Genetic Association Database (GAD)
KIF4B
genes like me logo Genes that share disorders with KIF4B: view

No data available for UniProtKB/Swiss-Prot for KIF4B Gene

Publications for KIF4B Gene

  1. Identification of the human homologue of mouse KIF4, a kinesin superfamily motor protein. (PMID: 10978527) Oh S.J. … Kim W. (Biochim. Biophys. Acta 2000) 3 4
  2. Emergence of young human genes after a burst of retroposition in primates. (PMID: 16201836) Marques A.C. … Kaessmann H. (PLoS Biol. 2005) 3 4
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  4. Kinesin KIF4 regulates intracellular trafficking and stability of the human immunodeficiency virus type 1 Gag polyprotein. (PMID: 18684836) Martinez N.W. … Resh M.D. (J. Virol. 2008) 3
  5. System-wide changes to SUMO modifications in response to heat shock. (PMID: 19471022) Golebiowski F. … Hay R.T. (Sci Signal 2009) 3

Products for KIF4B Gene

Sources for KIF4B Gene

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