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KIF4B Gene

protein-coding   GIFtS: 45
GCID: GC05P154393

Kinesin Family Member 4B

  Search for KIF4B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kinesin Family Member 4B1 2
chromokinesin-B2
Chromosome-Associated Kinesin KIF4B2
Chromokinesin-B3

External Ids:    HGNC: 63221   Entrez Gene: 2856432   Ensembl: ENSG000002266507   OMIM: 6091845   UniProtKB: Q2VIQ33   

Export aliases for KIF4B gene to outside databases

Previous GC identifers: GC05U990137 GC05P154374 GC05P149535


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KIF4B Gene:
KIF4B (kinesin family member 4B) is a protein-coding gene. GO annotations related to this gene include microtubule binding and microtubule motor activity. An important paralog of this gene is KIF4A.

UniProtKB/Swiss-Prot: KIF4B_HUMAN, Q2VIQ3
Function: Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the
metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and
midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle
stabilization (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_029289.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the KIF4B gene promoter:
         NF-1   NF-1/L   GATA-3   Brachyury   MyoD   HNF-3beta   GATA-2   GATA-1   C/EBPalpha   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for KIF4B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KIF4B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.1   Ensembl cytogenetic band:  5q33.2   HGNC cytogenetic band: 5q33.2

KIF4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIF4B gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P154393:  view genomic region     (about GC identifiers)

Start:
154,393,260 bp from pter      End:
154,397,685 bp from pter
Size:
4,426 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KIF4B_HUMAN, Q2VIQ3 (See protein sequence)
Recommended Name: Chromosome-associated kinesin KIF4B  
Size: 1234 amino acids; 140035 Da

Explore the universe of human proteins at neXtProt for KIF4B: NX_Q2VIQ3

Explore proteomics data for KIF4B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys840
  • Modification sites at PhosphoSitePlus

  • See KIF4B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001092763.1  
    ENSEMBL proteins: 
     ENSP00000387875  
    Reactome Protein details: Q2VIQ3

    KIF4B Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for KIF4B

     
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    Search eBioscience for ELISAs for KIF4B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KIF: Kinesins

    4 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR001752 Kinesin_motor_dom
     IPR019821 Kinesin_motor_CS
     IPR027640 Kinesin-like_fam

    Graphical View of Domain Structure for InterPro Entry Q2VIQ3

    ProtoNet protein and cluster: Q2VIQ3

    UniProtKB/Swiss-Prot: KIF4B_HUMAN, Q2VIQ3
    Similarity: Belongs to the kinesin-like protein family. Chromokinesin subfamily
    Similarity: Contains 1 kinesin-motor domain


    Find genes that share domains with KIF4B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KIF4B_HUMAN, Q2VIQ3
    Function: Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the
    metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and
    midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle
    stabilization (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003777microtubule motor activity IEA--
    GO:0005524ATP binding IEA--
    GO:0008017microtubule binding IEA--
         
    Find genes that share ontologies with KIF4B           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for KIF4B:
     Decreased Salmonella enterica  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KIF4B
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    miRNA
    Products:
        
    miRTarBase miRNAs that target KIF4B:
    hsa-mir-1226-3p (MIRT036533)

    Block miRNA regulation of human, mouse, rat KIF4B using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate KIF4B:
    hsa-miR-3143
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KIF4B_HUMAN, Q2VIQ3: Nucleus matrix (By similarity). Cytoplasm, cytoskeleton (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol4
    nucleus4

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005829cytosol TAS--
    GO:0005871kinesin complex IEA--
    GO:0005874microtubule IEA--

    Find genes that share ontologies with KIF4B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KIF4B About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1L1CAM interactions
    Axon guidance0.63
    L1CAM interactions0.36
    Developmental Biology0.63
    2Hemostasis
    Hemostasis0.43
    3Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    4Endocytic Trafficking of EGFR
    Recycling pathway of L10.33
    5MHC class II antigen presentation
    MHC class II antigen presentation


    Find genes that share SuperPaths with KIF4B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Reactome Pathways for KIF4B
        Recycling pathway of L1
    MHC class II antigen presentation
    Kinesins


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KIF4B
    Interactions:

        Search GeneGlobe Interaction Network for KIF4B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for KIF4B (Q2VIQ33 ENSP000003878754) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKAG2Q9UGJ03I2D: score=1 
    KCTD14ENSP000003164824STRING: ENSP00000316482
    SUMO2ENSP000004059654STRING: ENSP00000405965
    ENSG00000204197ENSP000003636474STRING: ENSP00000363647
    ENSG00000233450ENSP000004078854STRING: ENSP00000407885
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007018microtubule-based movement TAS--
    GO:0007411axon guidance TAS--
    GO:0007596blood coagulation TAS--
    GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II TAS--

    Find genes that share ontologies with KIF4B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KIF4B



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KIF4B gene: 
    NM_001099293.1  

    Unigene Cluster for KIF4B:

    Kinesin family member 4B
    Hs.567824  [show with all ESTs]
    Unigene Representative Sequence: NM_001099293
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000435029(uc010jih.1)
    miRNA
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    Block miRNA regulation of human, mouse, rat KIF4B using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate KIF4B:
    hsa-miR-3143
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat KIF4B
      QuantiTect SYBR Green Assays in human, mouse, rat KIF4B
      QuantiFast Probe-based Assays in human, mouse, rat KIF4B

    Additional mRNA sequence: AK302388.1 

    5 DOTS entries:

    DT.120852914  DT.100779924  DT.100779925  DT.452160  DT.99928543 

    1 AceView cDNA sequence:

    BI259443 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KIF4B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTTGAAGT
    KIF4B Expression
    About this image

    KIF4B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KIF4B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.567824

    UniProtKB/Swiss-Prot: KIF4B_HUMAN, Q2VIQ3
    Tissue specificity: Specifically expressed in testis

        Custom PCR Arrays for KIF4B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF4B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for KIF4B gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves KIF4A6
    Gallus gallus kinesin family member 4A (KIF4A), mR...
    73(a)
    1 → many
    4(1248686-1265752)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    65(a)
    57(a)
    many ↔ many
    many ↔ many
    GL343400.1(365282-390625)
    5(65040273-65043275)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.35092 Transcribed sequence with moderate similarity to protein more 80.19(n)    142026585 
    zebrafish
    (Danio rerio)
    Actinopterygii KIF4A6
    kinesin family member 4A
    60(a)
    1 → many
    21(43273690-43308834) ENSDARG00000005462
    fruit fly
    (Drosophila melanogaster)
    Insecta Klp3A6
    Kinesin-like protein at 3A
    33(a)
    1 → many
    X(2493190-2498085)
    worm
    (Caenorhabditis elegans)
    Secernentea klp-196
    Protein KLP-19 (klp-19) mRNA, complete cds
    32(a)
    1 → many
    III(13302743-13307259) WBGene00002229
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons FRA11 FRA1 47.53(n)
    41.04(a)
      834833  NM_124156.4  NP_199593.2 
    rice
    (Oryza sativa)
    Liliopsida Os09g01145001 Os09g0114500 49.88(n)
    42.12(a)
      4346402  NM_001069115.1  NP_001062580.1 
            Species with no ortholog for KIF4B

    ENSEMBL Gene Tree for KIF4B (if available)
    TreeFam Gene Tree for KIF4B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KIF4B gene
    KIF4A2  KIF3A2  KIF5B2  KIF5C2  KIF21A2  KIF112  KIF3B2  KIF21B2  
    KIF172  CENPE2  KIF152  KIF5A2  KIF72  KIF272  KIF3C2  
    1 SIMAP similar gene for KIF4B using alignment to 1 protein entry:     KIF4B_HUMAN:
    KIF4A

    Find genes that share paralogs with KIF4B           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for KIF4B
    PGOHUM00000241868


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KIF4B (see all 247)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1497797991,2
    C--154391333(+) CTGAAA/GTTAGA 1 -- us2k10--------
    rs801149441,2
    C,F--154391409(+) TTTAAC/TGGAGA 1 -- us2k11Minor allele frequency- T:0.07WA 118
    rs1807940471,2
    --154391416(+) GAGATA/GCAATT 1 -- us2k10--------
    rs750280201,2
    C,F--154391488(+) GAGCAT/CCCATC 1 -- us2k11Minor allele frequency- C:0.03EA 120
    rs133619241,2
    C,F,H--154391703(+) gctcaA/Cctttt 1 -- us2k15Minor allele frequency- C:0.01NS EA WA 538
    rs1419617591,2
    C--154391704(+) TTTTT-/T/TT  
            
    GTAAA
    1 -- us2k10--------
    rs1478830471,2
    C--154391835(+) AGAACA/GGTACA 1 -- us2k10--------
    rs776853831,2
    C,F--154391845(+) ATTTGT/GTATAA 1 -- us2k11Minor allele frequency- G:0.08WA 118
    rs623822511,2
    C,F--154391893(+) GCCAAT/CAGTTT 1 -- us2k14Minor allele frequency- C:0.07NA CSA WA 242
    rs1415105191,2
    --154392085(+) TGTGAA/GGTGTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KIF4B (154393260 - 154397685 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for KIF4B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv21446CNV Gain19812545
    nsv883058CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KIF4B
    DNA2.0 Custom Variant and Variant Library Synthesis for KIF4B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609184    OMIM disorders: --


    Find genes that share disorders with KIF4B           About GenesLikeMe

    Genetic Association Database (GAD): KIF4B

    Export disorders for KIF4B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KIF4B gene integrated from 10 sources:
    (articles sorted by number of sources associating them with KIF4B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Emergence of young human genes after a burst of retroposition in primates. (PubMed id 16201836)1, 2 Marques A.C.... Kaessmann H. (PLoS Biol. 2005)
    2. Identification of the human homologue of mouse KIF4, a kinesin superfamily motor protein. (PubMed id 10978527)1, 2 Oh S.J.... Kim W. (Biochim. Biophys. Acta 2000)
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    4. System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (Sci Signal 2009)
    5. Kinesin KIF4 regulates intracellular trafficking and stability of the human immunodeficiency virus type 1 Gag polyprotein. (PubMed id 18684836)1 Martinez N.W....Resh M.D. (J. Virol. 2008)
    6. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    7. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (Nature 2004)
    8. Assignment of the kinesin family member 4 genes (KIF4A and KIF4B) to human chromosome bands Xq13.1 and 5q33.1 by in situ hybridization. (PubMed id 10773663)1 Ha M.J....Kim W. (Cytogenet. Cell Genet. 2000)
    9. Cellular motor protein KIF-4 associates with retroviral Gag. (PubMed id 10559369)1 Tang Y....Morse H.C. (J. Virol. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 285643 HGNC: 6322 AceView: LOC285643 Ensembl:ENSG00000226650 euGenes: HUgn285643
    ECgene: KIF4B H-InvDB: KIF4B

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KIF4B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for KIF4B gene:
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    GeneCards and IP:
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