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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KIF4B Gene

protein-coding   GIFtS: 43
GCID: GC05P154393

Kinesin Family Member 4B

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Kinesin Family Member 4B1 2
chromokinesin-B2
Chromosome-Associated Kinesin KIF4B2
Chromokinesin-B3

External Ids:    HGNC: 63221   Entrez Gene: 2856432   Ensembl: ENSG000002266507   OMIM: 6091845   UniProtKB: Q2VIQ33   

Export aliases for KIF4B gene to outside databases

Previous GC identifers: GC05U990137 GC05P154374 GC05P149535


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for KIF4B Gene: 
KIF4B (kinesin family member 4B) is a protein-coding gene. Diseases associated with KIF4B include basal cell carcinoma, and among its related super-pathways are Axon guidance and Immune System. GO annotations related to this gene include microtubule motor activity and ATP binding. An important paralog of this gene is KIF4A.

UniProtKB/Swiss-Prot: KIF4B_HUMAN, Q2VIQ3
Function: Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the
metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and
midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle
stabilization (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_029289.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KIF4B gene promoter:
         NF-1   NF-1/L   GATA-3   Brachyury   MyoD   HNF-3beta   GATA-2   GATA-1   C/EBPalpha   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for KIF4B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIF4B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.1   Ensembl cytogenetic band:  5q33.2   HGNC cytogenetic band: 5q33.2

KIF4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIF4B gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P154393:  view genomic region     (about GC identifiers)

Start:
154,393,260 bp from pter      End:
154,397,685 bp from pter
Size:
4,426 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KIF4B_HUMAN, Q2VIQ3 (See protein sequence)
Recommended Name: Chromosome-associated kinesin KIF4B  
Size: 1234 amino acids; 140035 Da
Subcellular location: Nucleus matrix (By similarity). Cytoplasm, cytoskeleton (Probable)

Explore the universe of human proteins at neXtProt for KIF4B: NX_Q2VIQ3

Explore proteomics data for KIF4B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q2VIQ3

  • KIF4B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KIF4B Protein Expression
    REFSEQ proteins: NP_001092763.1  
    ENSEMBL proteins: 
     ENSP00000387875  
    Reactome Protein details: Q2VIQ3
    Human Recombinant Protein Products for KIF4B: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KIF4B 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005694chromosome ----
    GO:0005730NOT nucleolus IDA--
    GO:0005829cytosol TAS--
    GO:0005871kinesin complex IEA--

    KIF4B for ontologies           About GeneDecksing



    KIF4B Antibody Products: 
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    Cloud-Clone Corp. CLIAs for KIF4B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    KIF: Kinesins

    4 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR001752 Kinesin_motor_dom
     IPR019821 Kinesin_motor_CS
     IPR027327 KIF4

    Graphical View of Domain Structure for InterPro Entry Q2VIQ3

    ProtoNet protein and cluster: Q2VIQ3

    UniProtKB/Swiss-Prot: KIF4B_HUMAN, Q2VIQ3
    Similarity: Belongs to the kinesin-like protein family. Chromokinesin subfamily
    Similarity: Contains 1 kinesin-motor domain


    KIF4B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KIF4B_HUMAN, Q2VIQ3
    Function: Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the
    metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and
    midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle
    stabilization (By similarity)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003777microtubule motor activity IEA--
    GO:0005524ATP binding IEA--
    GO:0008017microtubule binding IEA--
         
    KIF4B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KIF4B:
     Decreased Salmonella enterica  

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for KIF4B 
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    miRNA
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    hsa-miR-3143
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    Inhib. RNA
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    Gene Editing
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    Clone
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KIF4B About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Axon guidance
    Axon guidance0.69
    L1CAM interactions0.39
    Developmental Biology0.69
    Recycling pathway of L10.38
    2Immune System
    Immune System0.56
    Adaptive Immune System0.56
    3MHC class II antigen presentation
    MHC class II antigen presentation0.32
    Kinesins0.32
    4Platelet activation, signaling and aggregation
    Hemostasis0.43
    5Factors involved in megakaryocyte development and platelet production
    Factors involved in megakaryocyte development and platelet production

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/10        Reactome Pathways for KIF4B (see all 10)
        Hemostasis
    L1CAM interactions
    Developmental Biology
    Adaptive Immune System
    Recycling pathway of L1



    KIF4B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIF4B

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for KIF4B (Q2VIQ33 ENSP000003878754) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKAG2Q9UGJ03I2D: score=1 
    SUMO2ENSP000004059654STRING: ENSP00000405965
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007018microtubule-based movement TAS--
    GO:0007411axon guidance TAS--
    GO:0007596blood coagulation TAS--
    GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II TAS--

    KIF4B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KIF4B

    Search CenterWatch for drugs/clinical trials and news about KIF4B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KIF4B gene: 
    NM_001099293.1  

    Unigene Cluster for KIF4B:

    Kinesin family member 4B
    Hs.567824  [show with all ESTs]
    Unigene Representative Sequence: NM_001099293
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000435029(uc010jih.1)
    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate KIF4B:
    hsa-miR-3143
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KIF4B
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    Additional mRNA sequence: AK302388.1 

    5 DOTS entries:

    DT.120852914  DT.100779924  DT.100779925  DT.452160  DT.99928543 

    1 AceView cDNA sequence:

    BI259443 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KIF4B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTTGAAGT
    KIF4B Expression
    About this image


    See KIF4B Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.567824

    UniProtKB/Swiss-Prot: KIF4B_HUMAN, Q2VIQ3
    Tissue specificity: Specifically expressed in testis

        SABiosciences Custom PCR Arrays for KIF4B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF4B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for KIF4B gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves KIF4A6
    chromosome-associated kinesin KIF4
    73(a)
    1 → many
    4(1248686-1265752)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    65(a)
    56(a)
    many ↔ many
    many ↔ many
    GL343400.1(365282-390625)
    5(65040273-65043275)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.35092 Transcribed sequence with moderate similarity to protein more 80.19(n)    142026585 
    zebrafish
    (Danio rerio)
    Actinopterygii KIF4A6
    kinesin family member 4A
    60(a)
    1 → many
    21(43273690-43308834)
    fruit fly
    (Drosophila melanogaster)
    Insecta Klp3A6
    Kinesin-like protein at 3A
    32(a)
    1 → many
    X(2493190-2498085)
    worm
    (Caenorhabditis elegans)
    Secernentea klp-196
    Protein KLP-19
    27(a)
    possible ortholog
    III(13302743-13307259)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G609301 kinesin family member 4/7/21/27 48.77(n)
    37.75(a)
      836214  NM_125486.2  NP_200901.2 
            Species with no ortholog for KIF4B

    ENSEMBL Gene Tree for KIF4B (if available)
    TreeFam Gene Tree for KIF4B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KIF4B gene
    KIF4A2  KIF21A2  KIF21B2  KIF122  KIF72  KIF272  
    1 SIMAP similar gene for KIF4B using alignment to 1 protein entry:     KIF4B_HUMAN:
    KIF4A

    KIF4B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for KIF4B
    PGOHUM00000241868


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/247 SNPs in KIF4B are shown (see all 247)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1497797991,2
    C--154391333(+) CTGAAA/GTTAGA 1 -- us2k10--------
    rs801149441,2
    C,F--154391409(+) TTTAAC/TGGAGA 1 -- us2k11Minor allele frequency- T:0.07WA 118
    rs1807940471,2
    --154391416(+) GAGATA/GCAATT 1 -- us2k10--------
    rs750280201,2
    C,F--154391488(+) GAGCAT/CCCATC 1 -- us2k11Minor allele frequency- C:0.03EA 120
    rs133619241,2
    C,F,H--154391703(+) gctcaA/Cctttt 1 -- us2k15Minor allele frequency- C:0.01NS EA WA 538
    rs1419617591,2
    C--154391704(+) TTTTT-/T/TT  
            
    GTAAA
    1 -- us2k10--------
    rs1478830471,2
    C--154391835(+) AGAACA/GGTACA 1 -- us2k10--------
    rs776853831,2
    C,F--154391845(+) ATTTGT/GTATAA 1 -- us2k11Minor allele frequency- G:0.08WA 118
    rs623822511,2
    C,F--154391893(+) GCCAAT/CAGTTT 1 -- us2k14Minor allele frequency- C:0.07NA CSA WA 242
    rs1415105191,2
    --154392085(+) TGTGAA/GGTGTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KIF4B (154393260 - 154397685 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for KIF4B:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv21446CNV Gain19812545
    nsv883058CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609184    OMIM disorders: --

    2 diseases for KIF4B:    About MalaCards
    basal cell carcinoma    


    KIF4B for disorders           About GeneDecksing

    Genetic Association Database (GAD): KIF4B

    Export disorders for KIF4B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KIF4B gene integrated from 9 sources:
    (articles sorted by number of sources associating them with KIF4B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Emergence of young human genes after a burst of retroposition in primates. (PubMed id 16201836)1, 2 Marques A.C.... Kaessmann H. (2005)
    2. Identification of the human homologue of mouse KIF4, a kinesin superfamily motor protein. (PubMed id 10978527)1, 2 Oh S.J.... Kim W. (2000)
    3. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    4. System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (2009)
    5. Kinesin KIF4 regulates intracellular trafficking and stability of the human immunodeficiency virus type 1 Gag polyprotein. (PubMed id 18684836)1 Martinez N.W....Resh M.D. (2008)
    6. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    7. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (2004)
    8. Assignment of the kinesin family member 4 genes (KIF4A and KIF4B) to human chromosome bands Xq13.1 and 5q33.1 by in situ hybridization. (PubMed id 10773663)1 Ha M.J....Kim W. (2000)
    9. Cellular motor protein KIF-4 associates with retroviral Gag. (PubMed id 10559369)1 Tang Y....Morse H.C. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 285643 HGNC: 6322 AceView: LOC285643 Ensembl:ENSG00000226650 euGenes: HUgn285643
    ECgene: KIF4B H-InvDB: KIF4B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KIF4B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for KIF4B gene:
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