Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KIF4A Gene

Aliases for KIF4A Gene

  • Kinesin Family Member 4A 2 3 5
  • Chromokinesin-A 3 4
  • KIF4 3 4
  • Chromosome-Associated Kinesin KIF4A 3
  • Chromokinesin 2
  • KIF4G1 3
  • MRX100 3

External Ids for KIF4A Gene

Previous GeneCards Identifiers for KIF4A Gene

  • GC0XP065687
  • GC0XP066987
  • GC0XP067743
  • GC0XP068376
  • GC0XP069292
  • GC0XP069427
  • GC0XP069428
  • GC0XP069509
  • GC0XP063330

Summaries for KIF4A Gene

Entrez Gene Summary for KIF4A Gene

  • This gene encodes a member of the kinesin 4 subfamily of kinesin related proteins. The encoded protein is an ATP dependent microtubule-based motor protein that is involved in the intracellular transport of membranous organelles. This protein also associates with condensed chromosome arms and may be involved in maintaining chromosome integrity during mitosis. This protein may also be involved in the organization of the central spindle prior to cytokinesis. A pseudogene of this gene is found on chromosome X.[provided by RefSeq, Mar 2010]

GeneCards Summary for KIF4A Gene

KIF4A (Kinesin Family Member 4A) is a Protein Coding gene. Diseases associated with KIF4A include Mental Retardation, X-Linked 100. Among its related pathways are Endocytic Trafficking of EGFR and Innate Immune System. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF4B.

UniProtKB/Swiss-Prot for KIF4A Gene

  • Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization.

Gene Wiki entry for KIF4A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF4A Gene

Genomics for KIF4A Gene

Regulatory Elements for KIF4A Gene

Enhancers for KIF4A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG070433 1.7 FANTOM5 Ensembl ENCODE 4.1 +144.6 144598 2.9 ATF1 ARID4B SIN3A BRCA1 ZNF2 ETS1 GLIS2 GATA2 ZNF143 KLF7 ARR3 DLG3 KIF4A LOC105373244 GDPD2
GH0XG070219 0.9 ENCODE 4.7 -69.8 -69795 1.0 PKNOX1 FOXA2 SIN3A TCF12 GATA2 FOS ZNF263 SP3 SP5 SREBF1 KIF4A RN7SL581P DGAT2L6
GH0XG070288 1 ENCODE 0.7 +0.1 83 2.3 ATF1 ARID4B SIN3A ETS1 GLIS2 ELK1 KLF7 ZNF263 SP3 SP5 IGBP1 ARR3 PDZD11 KIF4A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KIF4A on UCSC Golden Path with GeneCards custom track

Promoters for KIF4A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000247069 272 2600 ATF1 ARID4B SIN3A ETS1 GLIS2 ELK1 KLF7 ZNF263 SP3 SP5

Genomic Location for KIF4A Gene

Chromosome:
X
Start:
70,290,029 bp from pter
End:
70,420,924 bp from pter
Size:
130,896 bases
Orientation:
Plus strand

Genomic View for KIF4A Gene

Genes around KIF4A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF4A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF4A Gene

Proteins for KIF4A Gene

  • Protein details for KIF4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95239-KIF4A_HUMAN
    Recommended name:
    Chromosome-associated kinesin KIF4A
    Protein Accession:
    O95239
    Secondary Accessions:
    • B2R7V5
    • D3DVU4
    • Q86TN3
    • Q86XX7
    • Q9NNY6
    • Q9NY24
    • Q9UMW3

    Protein attributes for KIF4A Gene

    Size:
    1232 amino acids
    Molecular mass:
    139881 Da
    Quaternary structure:
    • Interacts with unphosphorylated PRC1 during late mitosis.
    SequenceCaution:
    • Sequence=AAH49218.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for KIF4A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF4A Gene

Post-translational modifications for KIF4A Gene

  • Ubiquitination at isoforms=2955
  • Modification sites at PhosphoSitePlus

Other Protein References for KIF4A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KIF4A Gene

Domains & Families for KIF4A Gene

Gene Families for KIF4A Gene

Protein Domains for KIF4A Gene

Suggested Antigen Peptide Sequences for KIF4A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95239

UniProtKB/Swiss-Prot:

KIF4A_HUMAN :
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Chromokinesin subfamily.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Chromokinesin subfamily.
genes like me logo Genes that share domains with KIF4A: view

Function for KIF4A Gene

Molecular function for KIF4A Gene

UniProtKB/Swiss-Prot Function:
Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization.

Gene Ontology (GO) - Molecular Function for KIF4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003777 microtubule motor activity TAS 7929562
GO:0005515 protein binding IPI 16431929
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
genes like me logo Genes that share ontologies with KIF4A: view
genes like me logo Genes that share phenotypes with KIF4A: view

Human Phenotype Ontology for KIF4A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for KIF4A Gene

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for KIF4A Gene

Localization for KIF4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF4A Gene

Nucleus matrix. Cytoplasm, cytoskeleton, spindle. Midbody. Chromosome. Note=Not present in the nucleolus. In early mitosis, associated with the mitotic spindle, in anaphase, localized to the spindle midzone and, in telophase and cytokinesis, to the midbody. In late cytokinesis, found in the center of the midbody. Associated with chromosomes at all stages of mitosis.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIF4A gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
extracellular 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for KIF4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005694 chromosome IEA --
GO:0005737 cytoplasm TAS 7929562
GO:0005819 spindle IEA --
genes like me logo Genes that share ontologies with KIF4A: view

Pathways & Interactions for KIF4A Gene

genes like me logo Genes that share pathways with KIF4A: view

Gene Ontology (GO) - Biological Process for KIF4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000281 mitotic cytokinesis IMP 15843429
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS --
GO:0006996 organelle organization TAS 7929562
GO:0007018 microtubule-based movement TAS --
GO:0008089 anterograde axonal transport TAS 7929562
genes like me logo Genes that share ontologies with KIF4A: view

No data available for SIGNOR curated interactions for KIF4A Gene

Drugs & Compounds for KIF4A Gene

(2) Drugs for KIF4A Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ispinesib (SB-715992) Pharma Kinesin spindle protein (KSP)inhibitor 0
SB743921 Pharma Potent KSP inhibitor 0

(2) ApexBio Compounds for KIF4A Gene

Compound Action Cas Number
Ispinesib (SB-715992) Kinesin spindle protein (KSP)inhibitor 336113-53-2
SB743921 Potent KSP inhibitor 940929-33-9
genes like me logo Genes that share compounds with KIF4A: view

Drug Products

Transcripts for KIF4A Gene

mRNA/cDNA for KIF4A Gene

Unigene Clusters for KIF4A Gene

Kinesin family member 4A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF4A Gene

No ASD Table

Relevant External Links for KIF4A Gene

GeneLoc Exon Structure for
KIF4A
ECgene alternative splicing isoforms for
KIF4A

Expression for KIF4A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIF4A Gene

Protein differential expression in normal tissues from HIPED for KIF4A Gene

This gene is overexpressed in Breast (45.2) and Liver (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KIF4A Gene



NURSA nuclear receptor signaling pathways regulating expression of KIF4A Gene:

KIF4A

SOURCE GeneReport for Unigene cluster for KIF4A Gene:

Hs.648326

mRNA Expression by UniProt/SwissProt for KIF4A Gene:

O95239-KIF4A_HUMAN
Tissue specificity: Highly expressed in hematopoietic tissues, fetal liver, spleen, thymus and adult thymus and bone marrow. Lower levels are found in heart, testis, kidney, colon and lung.

Evidence on tissue expression from TISSUES for KIF4A Gene

  • Liver(4.2)
  • Blood(4.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for KIF4A Gene

Germ Layers:
  • ectoderm
Systems:
  • nervous
Organs:
Head and neck:
  • brain
  • head
genes like me logo Genes that share expression patterns with KIF4A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for KIF4A Gene

Orthologs for KIF4A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KIF4A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF4A 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 95 (a)
OneToMany
KIF4A 34
  • 92.91 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 93 (a)
OneToMany
KIF4A 34
  • 91.83 (n)
mouse
(Mus musculus)
Mammalia Kif4 34 16 35
  • 86.68 (n)
rat
(Rattus norvegicus)
Mammalia Kif4a 34
  • 86.63 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 81 (a)
OneToMany
chicken
(Gallus gallus)
Aves KIF4A 34 35
  • 72.82 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 67 (a)
ManyToMany
-- 35
  • 59 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia kif4a 34
  • 68.94 (n)
African clawed frog
(Xenopus laevis)
Amphibia kif4a-A-prov 34
zebrafish
(Danio rerio)
Actinopterygii zgc:66125 34
  • 63.52 (n)
KIF4A 35
  • 62 (a)
OneToMany
zgc66125 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012471 34
  • 50.39 (n)
fruit fly
(Drosophila melanogaster)
Insecta Klp3A 36 34 35
  • 47.8 (n)
Kif19A 36
  • 38 (a)
nod 36
  • 35 (a)
worm
(Caenorhabditis elegans)
Secernentea klp-19 36 34 35
  • 46.42 (n)
klp-10 36
  • 27 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G60930 34
  • 50.65 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 47 (a)
OneToMany
Species where no ortholog for KIF4A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIF4A Gene

ENSEMBL:
Gene Tree for KIF4A (if available)
TreeFam:
Gene Tree for KIF4A (if available)

Paralogs for KIF4A Gene

(7) SIMAP similar genes for KIF4A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KIF4A: view

Variants for KIF4A Gene

Sequence variations from dbSNP and Humsavar for KIF4A Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs772129850 Uncertain significance 70,297,148(+) TAAAA(A/G)GAGTG reference, missense
rs1000004398 -- 70,352,816(+) AAATC(C/T)CTACC intron-variant
rs1000019156 -- 70,312,785(+) TCTTA(C/T)AATTT intron-variant
rs1000040910 -- 70,393,730(+) TTTTT(G/T)TCATG intron-variant
rs1000042871 -- 70,383,221(+) TCAAC(A/G)ATAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF4A Gene

Variant ID Type Subtype PubMed ID
esv1361658 CNV insertion 17803354
esv1584074 OTHER inversion 17803354
esv2740208 CNV deletion 23290073
esv33082 CNV loss 17666407
esv3445940 CNV duplication 20981092
esv3574036 CNV loss 25503493
nsv1077235 CNV deletion 25765185
nsv1140037 CNV duplication 24896259
nsv1148236 CNV insertion 26484159
nsv1150461 CNV duplication 26484159
nsv425219 CNV deletion 16902084
nsv6950 CNV insertion 18451855
nsv953427 CNV deletion 24416366

Variation tolerance for KIF4A Gene

Residual Variation Intolerance Score: 63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.40; 77.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIF4A Gene

Human Gene Mutation Database (HGMD)
KIF4A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIF4A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF4A Gene

Disorders for KIF4A Gene

MalaCards: The human disease database

(1) MalaCards diseases for KIF4A Gene - From: OMIM, ClinVar, and GeneCards

Disorder Aliases PubMed IDs
mental retardation, x-linked 100
  • mrx100
- elite association - COSMIC cancer census association via MalaCards
Search KIF4A in MalaCards View complete list of genes associated with diseases

Relevant External Links for KIF4A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIF4A
genes like me logo Genes that share disorders with KIF4A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIF4A Gene

Publications for KIF4A Gene

  1. Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis. (PMID: 15625105) Zhu C. … Jiang W. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 4 22 64
  2. Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation. (PMID: 15297875) Kurasawa Y. … Todokoro K. (EMBO J. 2004) 3 4 22 64
  3. Human kinesin superfamily member 4 is dominantly localized in the nuclear matrix and is associated with chromosomes during mitosis. (PMID: 11736643) Lee Y.M. … Kim W. (Biochem. J. 2001) 3 4 22 64
  4. Increased chromokinesin immunoreactivity in retinoblastoma cells. (PMID: 9168136) Yan R.-T. … Wang S.-Z. (Gene 1997) 3 4 22 64
  5. Structural requirements of chromokinesin Kif4A for its proper function in mitosis. (PMID: 18502200) Wu G. … Chen P.L. (Biochem. Biophys. Res. Commun. 2008) 3 22 64

Products for KIF4A Gene

Sources for KIF4A Gene

Content
Loading form....