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Aliases for KIF4A Gene

Aliases for KIF4A Gene

  • Kinesin Family Member 4A 2 3 5
  • Chromokinesin-A 3 4
  • KIF4 3 4
  • Chromokinesin 2
  • KIF4G1 3
  • MRX100 3

External Ids for KIF4A Gene

Previous GeneCards Identifiers for KIF4A Gene

  • GC0XP065687
  • GC0XP066987
  • GC0XP067743
  • GC0XP068376
  • GC0XP069292
  • GC0XP069427
  • GC0XP069428
  • GC0XP069509
  • GC0XP063330

Summaries for KIF4A Gene

Entrez Gene Summary for KIF4A Gene

  • This gene encodes a member of the kinesin 4 subfamily of kinesin related proteins. The encoded protein is an ATP dependent microtubule-based motor protein that is involved in the intracellular transport of membranous organelles. This protein also associates with condensed chromosome arms and may be involved in maintaining chromosome integrity during mitosis. This protein may also be involved in the organization of the central spindle prior to cytokinesis. A pseudogene of this gene is found on chromosome X.[provided by RefSeq, Mar 2010]

GeneCards Summary for KIF4A Gene

KIF4A (Kinesin Family Member 4A) is a Protein Coding gene. Diseases associated with KIF4A include Mental Retardation, X-Linked 100. Among its related pathways are Golgi-to-ER retrograde transport and RB in Cancer. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF5C.

UniProtKB/Swiss-Prot for KIF4A Gene

  • Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization.

Gene Wiki entry for KIF4A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF4A Gene

Genomics for KIF4A Gene

Regulatory Elements for KIF4A Gene

Enhancers for KIF4A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KIF4A on UCSC Golden Path with GeneCards custom track

Promoters for KIF4A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KIF4A on UCSC Golden Path with GeneCards custom track

Genomic Location for KIF4A Gene

Chromosome:
X
Start:
70,290,029 bp from pter
End:
70,420,924 bp from pter
Size:
130,896 bases
Orientation:
Plus strand

Genomic View for KIF4A Gene

Genes around KIF4A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF4A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF4A Gene

Proteins for KIF4A Gene

  • Protein details for KIF4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95239-KIF4A_HUMAN
    Recommended name:
    Chromosome-associated kinesin KIF4A
    Protein Accession:
    O95239
    Secondary Accessions:
    • B2R7V5
    • D3DVU4
    • Q86TN3
    • Q86XX7
    • Q9NNY6
    • Q9NY24
    • Q9UMW3

    Protein attributes for KIF4A Gene

    Size:
    1232 amino acids
    Molecular mass:
    139881 Da
    Quaternary structure:
    • Interacts with unphosphorylated PRC1 during late mitosis.
    SequenceCaution:
    • Sequence=AAH49218.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for KIF4A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF4A Gene

Proteomics data for KIF4A Gene at MOPED

Post-translational modifications for KIF4A Gene

  • Ubiquitination at Lys 955
  • Modification sites at PhosphoSitePlus

Other Protein References for KIF4A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KIF4A Gene

Domains & Families for KIF4A Gene

Gene Families for KIF4A Gene

Protein Domains for KIF4A Gene

Suggested Antigen Peptide Sequences for KIF4A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95239

UniProtKB/Swiss-Prot:

KIF4A_HUMAN :
  • Contains 1 kinesin motor domain.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Chromokinesin subfamily.
Domain:
  • Contains 1 kinesin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Chromokinesin subfamily.
genes like me logo Genes that share domains with KIF4A: view

Function for KIF4A Gene

Molecular function for KIF4A Gene

UniProtKB/Swiss-Prot Function:
Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization.

Gene Ontology (GO) - Molecular Function for KIF4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with KIF4A: view
genes like me logo Genes that share phenotypes with KIF4A: view

Human Phenotype Ontology for KIF4A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for KIF4A Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for KIF4A Gene

Localization for KIF4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF4A Gene

Nucleus matrix. Cytoplasm, cytoskeleton, spindle. Midbody. Chromosome. Note=Not present in the nucleolus. In early mitosis, associated with the mitotic spindle, in anaphase, localized to the spindle midzone and, in telophase and cytokinesis, to the midbody. In late cytokinesis, found in the center of the midbody. Associated with chromosomes at all stages of mitosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIF4A Gene COMPARTMENTS Subcellular localization image for KIF4A gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for KIF4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 7929562
GO:0005829 cytosol TAS --
GO:0005876 spindle microtubule TAS 7929562
GO:0030496 midbody IDA 15166316
genes like me logo Genes that share ontologies with KIF4A: view

Pathways & Interactions for KIF4A Gene

genes like me logo Genes that share pathways with KIF4A: view

Gene Ontology (GO) - Biological Process for KIF4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007018 microtubule-based movement IEA,TAS --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with KIF4A: view

No data available for SIGNOR curated interactions for KIF4A Gene

Drugs & Compounds for KIF4A Gene

(2) Drugs for KIF4A Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ispinesib (SB-715992) Pharma Kinesin spindle protein (KSP)inhibitor 0
SB743921 Pharma Potent KSP inhibitor 0

(2) ApexBio Compounds for KIF4A Gene

Compound Action Cas Number
Ispinesib (SB-715992) Kinesin spindle protein (KSP)inhibitor 336113-53-2
SB743921 Potent KSP inhibitor 940929-33-9
genes like me logo Genes that share compounds with KIF4A: view

Transcripts for KIF4A Gene

mRNA/cDNA for KIF4A Gene

Unigene Clusters for KIF4A Gene

Kinesin family member 4A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIF4A Gene

No ASD Table

Relevant External Links for KIF4A Gene

GeneLoc Exon Structure for
KIF4A
ECgene alternative splicing isoforms for
KIF4A

Expression for KIF4A Gene

mRNA expression in normal human tissues for KIF4A Gene

Protein differential expression in normal tissues from HIPED for KIF4A Gene

This gene is overexpressed in Breast (45.2) and Liver (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIF4A Gene



SOURCE GeneReport for Unigene cluster for KIF4A Gene Hs.648326

mRNA Expression by UniProt/SwissProt for KIF4A Gene

O95239-KIF4A_HUMAN
Tissue specificity: Highly expressed in hematopoietic tissues, fetal liver, spleen, thymus and adult thymus and bone marrow. Lower levels are found in heart, testis, kidney, colon and lung.
genes like me logo Genes that share expression patterns with KIF4A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for KIF4A Gene

Orthologs for KIF4A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KIF4A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KIF4A 35
  • 91.83 (n)
  • 93.1 (a)
-- 36
  • 93 (a)
OneToMany
dog
(Canis familiaris)
Mammalia KIF4A 35
  • 92.91 (n)
  • 95.05 (a)
-- 36
  • 95 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Kif4 35
  • 86.68 (n)
  • 87.31 (a)
Kif4 16
Kif4 36
  • 87 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Kif4a 35
  • 86.63 (n)
  • 86.74 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 81 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia KIF4A 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIF4A 35
  • 72.82 (n)
  • 76.66 (a)
KIF4A 36
  • 75 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 59 (a)
ManyToMany
-- 36
  • 67 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia kif4a 35
  • 68.94 (n)
  • 71.82 (a)
African clawed frog
(Xenopus laevis)
Amphibia kif4a-A-prov 35
zebrafish
(Danio rerio)
Actinopterygii zgc66125 35
zgc:66125 35
  • 63.52 (n)
  • 63.77 (a)
KIF4A 36
  • 62 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Kif19A 37
  • 38 (a)
Klp3A 37
  • 36 (a)
nod 37
  • 35 (a)
Klp3A 35
  • 47.8 (n)
  • 40.21 (a)
Klp3A 36
  • 34 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012471 35
  • 50.39 (n)
  • 48.26 (a)
worm
(Caenorhabditis elegans)
Secernentea klp-10 37
  • 27 (a)
klp-19 37
  • 32 (a)
klp-19 35
  • 46.42 (n)
  • 37.2 (a)
klp-19 36
  • 33 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G60930 35
  • 50.65 (n)
  • 42.09 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToMany
Species with no ortholog for KIF4A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIF4A Gene

ENSEMBL:
Gene Tree for KIF4A (if available)
TreeFam:
Gene Tree for KIF4A (if available)

Paralogs for KIF4A Gene

(7) SIMAP similar genes for KIF4A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KIF4A: view

Variants for KIF4A Gene

Sequence variations from dbSNP and Humsavar for KIF4A Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1199457 - 70,341,930(-) TTACC(A/C)AAATG reference, missense
rs2297871 - 70,352,640(-) CCACC(A/G)CAGTA reference, missense
rs1046485 - 70,420,144(+) AGAGT(C/T)GAAAC reference, missense
rs747671063 -- 70,373,592(+) TATAC(A/G)TATAT intron-variant
rs747672005 -- 70,373,768(+) TACGT(A/G)TATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF4A Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER Inversion 17803354
esv1361658 CNV Insertion 17803354
nsv425219 CNV Loss 16902084
esv2740208 CNV Deletion 23290073
nsv6950 CNV Insertion 18451855
esv33082 CNV Loss 17666407

Variation tolerance for KIF4A Gene

Residual Variation Intolerance Score: 63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.40; 77.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIF4A Gene

Human Gene Mutation Database (HGMD)
KIF4A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF4A Gene

Disorders for KIF4A Gene

MalaCards: The human disease database

(1) MalaCards diseases for KIF4A Gene - From: OMIM and ClinVar

Disorder Aliases PubMed IDs
mental retardation, x-linked 100
  • mrx100
- elite association - COSMIC cancer census association via MalaCards
Search KIF4A in MalaCards View complete list of genes associated with diseases

Relevant External Links for KIF4A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIF4A
genes like me logo Genes that share disorders with KIF4A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIF4A Gene

Publications for KIF4A Gene

  1. Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis. (PMID: 15625105) Zhu C. … Jiang W. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 4 23 67
  2. Structural requirements of chromokinesin Kif4A for its proper function in mitosis. (PMID: 18502200) Wu G. … Chen P.L. (Biochem. Biophys. Res. Commun. 2008) 3 23
  3. KIF14 and citron kinase act together to promote efficient cytokinesis. (PMID: 16431929) Gruneberg U. … Barr F.A. (J. Cell Biol. 2006) 3 23
  4. Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference. (PMID: 15843429) Zhu C. … Jiang W. (Mol. Biol. Cell 2005) 3 23
  5. Kinesin superfamily protein member 4 (KIF4) is localized to midzone and midbody in dividing cells. (PMID: 15031677) Lee Y.M. … Kim W. (Exp. Mol. Med. 2004) 3 23

Products for KIF4A Gene

Sources for KIF4A Gene

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