Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KIF4A Gene

protein-coding   GIFtS: 58
GCID: GC0XP069509

Kinesin Family Member 4A

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Kinesin Family Member 4A1 2     chromokinesin-A2
KIF42 3 5     Chromosome-Associated Kinesin KIF4A2
chromokinesin1     Chromokinesin-A3
KIF4G12     

External Ids:    HGNC: 133391   Entrez Gene: 241372   Ensembl: ENSG000000908897   OMIM: 3005215   UniProtKB: O952393   

Export aliases for KIF4A gene to outside databases

Previous GC identifers: GC0XP065687 GC0XP066987 GC0XP067743 GC0XP068376 GC0XP069292 GC0XP069427 GC0XP069428 GC0XP063330


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KIF4A Gene:
This gene encodes a member of the kinesin 4 subfamily of kinesin related proteins. The encoded protein is an ATP
dependent microtubule-based motor protein that is involved in the intracellular transport of membranous
organelles. This protein also associates with condensed chromosome arms and may be involved in maintaining
chromosome integrity during mitosis. This protein may also be involved in the organization of the central spindle
prior to cytokinesis. A pseudogene of this gene is found on chromosome X.(provided by RefSeq, Mar 2010)

GeneCards Summary for KIF4A Gene: 
KIF4A (kinesin family member 4A) is a protein-coding gene. Diseases associated with KIF4A include retinoblastoma, and lung cancer, and among its related super-pathways are Axon guidance and Immune System. GO annotations related to this gene include microtubule motor activity and ATP binding. An important paralog of this gene is KIF21A.

UniProtKB/Swiss-Prot: KIF4A_HUMAN, O95239
Function: Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the
metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and
midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle
stabilization

Gene Wiki entry for KIF4A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_011669.17  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KIF4A gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 2   Tal-1beta   E47   Egr-2   Hand1   AP-2alpha isoform 4   AP-2alpha   ITF-2   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKIF4A promoter sequence
   Search SABiosciences Chromatin IP Primers for KIF4A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIF4A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq13.1   Ensembl cytogenetic band:  Xq13.1   HGNC cytogenetic band: Xq13.1

KIF4A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIF4A gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP069509:  view genomic region     (about GC identifiers)

Start:
69,509,879 bp from pter      End:
69,640,774 bp from pter
Size:
130,896 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KIF4A_HUMAN, O95239 (See protein sequence)
Recommended Name: Chromosome-associated kinesin KIF4A  
Size: 1232 amino acids; 139881 Da
Subunit: Interacts with unphosphorylated PRC1 during late mitosis
Subcellular location: Nucleus matrix. Cytoplasm, cytoskeleton, spindle. Midbody. Chromosome. Note=Not present in
the nucleolus. In early mitosis, associated with the mitotic spindle, in anaphase, localized to the spindle
midzone and, in telophase and cytokinesis, to the midbody. In late cytokinesis, found in the center of the
midbody. Associated with chromosomes at all stages of mitosis
Sequence caution: Sequence=AAH49218.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
Secondary accessions: B2R7V5 D3DVU4 Q86TN3 Q86XX7 Q9NNY6 Q9NY24 Q9UMW3
Alternative splicing: 2 isoforms:  O95239-1   O95239-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KIF4A: NX_O95239

Explore proteomics data for KIF4A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95239

  • KIF4A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KIF4A Protein Expression
    REFSEQ proteins: NP_036442.3  
    ENSEMBL proteins: 
     ENSP00000363524   ENSP00000363509  
    Reactome Protein details: O95239
    Human Recombinant Protein Products for KIF4A: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for KIF4A
    GenScript Custom Purified and Recombinant Proteins Services for KIF4A
    Novus Biologicals KIF4A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KIF4A 

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005694chromosome IEA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm TAS7929562
    GO:0005829cytosol TAS--

    KIF4A for ontologies           About GeneDecksing



    KIF4A Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for KIF4A
    OriGene Custom Antibody Services for KIF4A
    GenScript Custom Superior Antibodies Services for KIF4A
    Novus Biologicals KIF4A Antibodies
    Abcam antibodies for KIF4A
    Cloud-Clone Corp. Antibodies for KIF4A 
    ThermoFisher Antibody for KIF4A
    LSBio Antibodies in human, mouse, rat for KIF4A 

    Assay Products for KIF4A: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KIF4A
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KIF4A
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for KIF4A 
    Cloud-Clone Corp. CLIAs for KIF4A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    KIF: Kinesins

    4 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR001752 Kinesin_motor_dom
     IPR019821 Kinesin_motor_CS
     IPR027327 KIF4

    Graphical View of Domain Structure for InterPro Entry O95239

    ProtoNet protein and cluster: O95239

    1 Blocks protein domain: IPB001752 Kinesin

    UniProtKB/Swiss-Prot: KIF4A_HUMAN, O95239
    Similarity: Belongs to the kinesin-like protein family. Chromokinesin subfamily
    Similarity: Contains 1 kinesin-motor domain


    KIF4A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KIF4A_HUMAN, O95239
    Function: Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the
    metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and
    midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle
    stabilization

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003777microtubule motor activity IEA--
    GO:0005524ATP binding IEA--
    GO:0008017microtubule binding IEA--
         
    KIF4A for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for KIF4A:
     G2 arrest  Increased G2M DNA content 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Kif4):
     normal 

    KIF4A for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for KIF4A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KIF4A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KIF4A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KIF4A 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KIF4A
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate KIF4A:
    hsa-miR-767-3p hsa-miR-516b hsa-miR-3143 hsa-miR-543
    SwitchGear 3'UTR luciferase reporter plasmidKIF4A 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KIF4A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIF4A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KIF4A
    Sirion Biotech Customized adenovirus for overexpression of KIF4A

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for KIF4A (see all 5)
    OriGene ORF clones in mouse, rat for KIF4A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KIF4A (NM_012310)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KIF4A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIF4A
    Sirion Biotech Customized lentivirus for stable overexpression of KIF4A 
                         Customized lentivirus expression plasmids for stable overexpression of KIF4A 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KIF4A
    Search LifeMap BioReagents cell lines for KIF4A
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF4A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KIF4A About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Axon guidance
    Axon guidance0.69
    L1CAM interactions0.39
    Developmental Biology0.69
    Recycling pathway of L10.38
    2Immune System
    Immune System0.56
    Adaptive Immune System0.56
    3MHC class II antigen presentation
    MHC class II antigen presentation0.32
    Kinesins0.32
    4Platelet activation, signaling and aggregation
    Hemostasis0.43
    5Factors involved in megakaryocyte development and platelet production
    Factors involved in megakaryocyte development and platelet production

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/10        Reactome Pathways for KIF4A (see all 10)
        Hemostasis
    L1CAM interactions
    Developmental Biology
    Adaptive Immune System
    Recycling pathway of L1



    KIF4A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KIF4A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/815 Interacting proteins for KIF4A (O952392, 3 ENSP000003635244) via UniProtKB, MINT, STRING, and/or I2D (see all 815)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TBL1XR1Q9BZK72, ENSP000004055744MINT-7945693 MINT-7947479 STRING: ENSP00000405574
    TUBG1P232582, ENSP000002514134MINT-7945693 MINT-7947479 STRING: ENSP00000251413
    TUBGCP3Q96CW52, ENSP000002619654MINT-7945693 MINT-7947479 STRING: ENSP00000261965
    SUMO1P631652, 3, ENSP000003760764MINT-7947479 I2D: score=1 STRING: ENSP00000376076
    CDC5LQ994592, ENSP000003605324MINT-7945693 MINT-7947479 STRING: ENSP00000360532
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006996organelle organization TAS7929562
    GO:0007018microtubule-based movement TAS--
    GO:0007411axon guidance TAS--
    GO:0007596blood coagulation TAS--
    GO:0008089anterograde axon cargo transport TAS7929562

    KIF4A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KIF4A

    Search CenterWatch for drugs/clinical trials and news about KIF4A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KIF4A gene: 
    NM_012310.4  

    Unigene Cluster for KIF4A:

    Kinesin family member 4A
    Hs.648326  [show with all ESTs]
    Unigene Representative Sequence: NM_012310
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374403(uc004dyg.3 uc010nkw.3) ENST00000485406 ENST00000374388(uc004dyf.2)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KIF4A
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate KIF4A:
    hsa-miR-767-3p hsa-miR-516b hsa-miR-3143 hsa-miR-543
    SwitchGear 3'UTR luciferase reporter plasmidKIF4A 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KIF4A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIF4A
    Clone
    Products:
         
    OriGene clones in human, mouse for KIF4A (see all 5)
    OriGene ORF clones in mouse, rat for KIF4A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KIF4A (NM_012310)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KIF4A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIF4A
    Sirion Biotech Customized lentivirus for stable overexpression of KIF4A 
                         Customized lentivirus expression plasmids for stable overexpression of KIF4A 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for KIF4A
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KIF4A
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIF4A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIF4A

    Additional mRNA sequence: 

    AB208797.1 AF071592.2 AF179308.1 AF277375.1 AJ271784.1 AK000638.1 AK022592.1 AK022717.1 
    AK024266.1 BC003664.2 BC011801.1 BC038459.1 BC049218.1 BC050548.1 

    14 DOTS entries:

    DT.452160  DT.100779925  DT.101983228  DT.100811858  DT.100811859  DT.120852914  DT.121288381  DT.75158650 
    DT.95237489  DT.95302581  DT.95369020  DT.100779924  DT.101984511  DT.99928543 

    24/181 AceView cDNA sequences (see all 181):

    CK000149 AA768164 CA415618 AA603659 BM462717 BE207964 Z39592 AI492247 
    AI611057 F02874 BF969754 BM802668 CR614099 BE501179 BX102383 BF791634 
    BU501525 BU429958 AW474709 BC050548 BM464206 BQ232841 BU521317 AI373555 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KIF4A expression in normal human tissues (normalized intensities)      KIF4A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTTGAAGC
    KIF4A Expression
    About this image


    KIF4A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/20 selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Thalamus
             brain/midbrain   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Secondary Oocyte Antral Follicle
     
     Gonad
             Secondary Oocyte Antral Follicle
     
     Eye (Sensory Organs)
             Retina

    See KIF4A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KIF4A

    SOURCE GeneReport for Unigene cluster: Hs.648326

    UniProtKB/Swiss-Prot: KIF4A_HUMAN, O95239
    Tissue specificity: Highly expressed in hematopoietic tissues, fetal liver, spleen, thymus and adult thymus and
    bone marrow. Lower levels are found in heart, testis, kidney, colon and lung

        SABiosciences Custom PCR Arrays for KIF4A
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for KIF4A
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KIF4A
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIF4A
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIF4A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF4A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for KIF4A gene from 9/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kif41 , 5 kinesin family member 41, 5 86.76(n)1
    87.39(a)1
      X (43.72 cM)5
    165711  NM_008446.21  NP_032472.21 
     1006257375 
    chicken
    (Gallus gallus)
    Aves KIF4A1 kinesin family member 4A 72.96(n)
    76.66(a)
      395823  NM_204975.1  NP_990306.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    66(a)
    58(a)
    many ↔ many
    many ↔ many
    GL343400.1(365282-390625)
    5(65040273-65043275)
    African clawed frog
    (Xenopus laevis)
    Amphibia kif4a-A-prov2 kinesin family member 4A 75.36(n)    X82012.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc661252 hypothetical protein MGC66125 74.19(n)   393796  BC060673.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Kif19A3
    Klp3A1
    microtubule-based movement kinesin
    motor3
    Kinesin-like protein at 3A1
    38(a)
    (best of 3)3
    46.8(n)1
    38.26(a)1
      88A93
    312401  NM_080314.21  NP_525053.11 
    worm
    (Caenorhabditis elegans)
    Secernentea klp-191 , 3 Kinesin motor domain3
    Protein KLP-191
    32(a)
    (best of 2)3
    45.63(n)1
    34.78(a)1
      III(13374305-13378476)3
    1767501  NM_067341.21  NP_499742.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons FRA11 kinesin family member 4/7/21/27 47.95(n)
    41.71(a)
      834833  NM_124156.4  NP_199593.2 
    rice
    (Oryza sativa)
    Liliopsida Os09g01145001 hypothetical protein 50.66(n)
    44.18(a)
      4346402  NM_001069115.1  NP_001062580.1 


    ENSEMBL Gene Tree for KIF4A (if available)
    TreeFam Gene Tree for KIF4A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KIF4A gene
    KIF21A2  KIF21B2  KIF122  KIF4B2  KIF72  KIF272  
    7 SIMAP similar genes for KIF4A using alignment to 2 protein entries:     KIF4A_HUMAN (see all proteins):
    KIF4B    KIF21A    CENPE    KIF17    KIF3A    KIF21B
    KIF3B

    KIF4A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1713 SNPs in KIF4A are shown (see all 1713)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1461693811,2
    C--69515800(+) TTCTC-/AGAGATA 1 -- int10--------
    rs358059201,2
    C--69515801(+) TCAGA-/GATAAAC 1 -- int10--------
    rs1504733011,2
    C--69515911(+) AGTAAC/TGATCC 1 -- us2k10--------
    rs1454188171,2
    C--69516039(+) GACCAC/TAAACA 1 -- us2k10--------
    rs1906135561,2
    --69516077(+) AATAGC/TTCAGC 1 -- us2k10--------
    rs1828578371,2
    --69516194(+) CCCCCA/CAACAC 1 -- us2k10--------
    rs348319141,2
    C--69516347(+) AAGACA/CCAGCA 1 -- us2k10--------
    rs1879567691,2
    --69516472(+) ACACAA/GACTAA 1 -- us2k10--------
    rs1491788701,2
    C--69516480(+) TAAATA/GAGTAG 1 -- us2k10--------
    rs673278031,2
    C--69516530(+) TCACC-/TTTTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KIF4A (69509879 - 69640774 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for KIF4A:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2740208CNV Deletion23290073
    nsv6950CNV Insertion18451855
    esv1361658CNV Insertion17803354
    esv33082CNV Loss17666407
    nsv425219CNV Loss16902084
    esv1584074OTHER Inversion17803354


    Locus Specific Mutation Databases (LSDB): KIF4A
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KIF4A
    DNA2.0 Custom Variant and Variant Library Synthesis for KIF4A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300521    OMIM disorders: --

    2 diseases for KIF4A:    About MalaCards
    retinoblastoma    lung cancer


    KIF4A for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for KIF4A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 29 3 9168136 (3)
    tumors 0 2 11745462 (1)


    Export disorders for KIF4A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KIF4A gene, integrated from 9 sources (see all 70):
    (articles sorted by number of sources associating them with KIF4A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis. (PubMed id 15625105)1, 2, 9 Zhu C. and Jiang W. (2005)
    2. Human kinesin superfamily member 4 is dominantly localized in the nuclear matrix and is associated with chromosomes during mitosis. (PubMed id 11736643)1, 2, 9 Lee Y.M.... Kim W. (2001)
    3. Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation. (PubMed id 15297875)1, 2, 9 Kurasawa Y.... Todokoro K. (2004)
    4. Increased chromokinesin immunoreactivity in retinoblastoma cells. (PubMed id 9168136)1, 2, 9 Yan R.-T. and Wang S.-Z. (1997)
    5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Assignment of the kinesin family member 4 genes (KIF4A and KIF4B) to human chromosome bands Xq13.1 and 5q33.1 by in situ hybridization. (PubMed id 10773663)1, 3 Ha M.J....Kim W. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 24137 HGNC: 13339 AceView: KIF4A Ensembl:ENSG00000090889 euGenes: HUgn24137
    ECgene: KIF4A H-InvDB: KIF4A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KIF4A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KIF4A gene:
    Search GeneIP for patents involving KIF4A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for KIF4A   OriGene RNAi products in human, mouse, rat for KIF4A  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for KIF4A  
     OriGene qSTAR qPCR primer pairs in human, mouse for KIF4A   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for KIF4A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KIF4A   OriGene Custom Protein Services for KIF4A  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KIF4A
     QIAGEN SeqTarget long-range PCR primers for resequencing KIF4A
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIF4A
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIF4A
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIF4A
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIF4A
     GenScript Custom Purified and Recombinant Proteins Services for KIF4A GenScript cDNA clones with any tag delivered in your preferred vector for KIF4A
     GenScript Custom Assay Services for KIF4A GenScript Custom Superior Antibodies Services for KIF4A
     GenScript Custom overexpressing Cell Line Services for KIF4A CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in KIF4A promoter
     Search Chromatin IP Primers for KIF4A
     RT2 qPCR Primer Assay in human, mouse, rat KIF4A
     GNC Network for KIF4A
     SABiosciences Custom PCR Arrays for KIF4A
     Search Tocris compounds for KIF4A
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     KIF4A antibodies
     KIF4A lysates
     Antibodies for KIF4A
     See all of Abcam's Antibodies, Kits and Proteins for KIF4A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for KIF4A
     Antibodies for KIF4A
     ELISAs for KIF4A
     CLIAs for KIF4A
     Search LifeMap BioReagents cell lines for KIF4A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF4A
     SwitchGear 3'UTR luciferase reporter plasmids for KIF4A
     SwitchGear Promoter luciferase reporter plasmids for KIF4A
     ThermoFisher Antibody for KIF4A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIF4A
     inGenious Targeting Laboratory - Custom generated mouse model solutions for KIF4A
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KIF4A
    Customized:
     lentivirus for stable overexpression of KIF4A
     lentivirus expression plasmids for stable overexpression of KIF4A
     adenovirus for overexpression of KIF4A
     LSBio Antibodies in human, mouse, rat for KIF4A
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KIF4A gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4