Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KIF4A Gene

Aliases for KIF4A Gene

  • Kinesin Family Member 4A 2 3
  • KIF4 3 4 6
  • Chromokinesin-A 3 4
  • Chromosome-Associated Kinesin KIF4A 3
  • Chromokinesin 2
  • KIF4G1 3
  • MRX100 3

External Ids for KIF4A Gene

Previous GeneCards Identifiers for KIF4A Gene

  • GC0XP065687
  • GC0XP066987
  • GC0XP067743
  • GC0XP068376
  • GC0XP069292
  • GC0XP069427
  • GC0XP069428
  • GC0XP069509
  • GC0XP063330

Summaries for KIF4A Gene

Entrez Gene Summary for KIF4A Gene

  • This gene encodes a member of the kinesin 4 subfamily of kinesin related proteins. The encoded protein is an ATP dependent microtubule-based motor protein that is involved in the intracellular transport of membranous organelles. This protein also associates with condensed chromosome arms and may be involved in maintaining chromosome integrity during mitosis. This protein may also be involved in the organization of the central spindle prior to cytokinesis. A pseudogene of this gene is found on chromosome X.[provided by RefSeq, Mar 2010]

GeneCards Summary for KIF4A Gene

KIF4A (Kinesin Family Member 4A) is a Protein Coding gene. Diseases associated with KIF4A include mental retardation, x-linked 100. Among its related pathways are Class I MHC mediated antigen processing and presentation and L1CAM interactions. GO annotations related to this gene include microtubule binding and microtubule motor activity. An important paralog of this gene is KIF5C.

UniProtKB/Swiss-Prot for KIF4A Gene

  • Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization.

Gene Wiki entry for KIF4A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF4A Gene

Genomics for KIF4A Gene

Genomic Location for KIF4A Gene

Start:
70,290,029 bp from pter
End:
70,420,924 bp from pter
Size:
130,896 bases
Orientation:
Plus strand

Genomic View for KIF4A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIF4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF4A Gene

Proteins for KIF4A Gene

  • Protein details for KIF4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95239-KIF4A_HUMAN
    Recommended name:
    Chromosome-associated kinesin KIF4A
    Protein Accession:
    O95239
    Secondary Accessions:
    • B2R7V5
    • D3DVU4
    • Q86TN3
    • Q86XX7
    • Q9NNY6
    • Q9NY24
    • Q9UMW3

    Protein attributes for KIF4A Gene

    Size:
    1232 amino acids
    Molecular mass:
    139881 Da
    Quaternary structure:
    • Interacts with unphosphorylated PRC1 during late mitosis.
    SequenceCaution:
    • Sequence=AAH49218.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for KIF4A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF4A Gene

Proteomics data for KIF4A Gene at MOPED

Post-translational modifications for KIF4A Gene

  • Ubiquitination at Lys840 and Lys955
  • Modification sites at PhosphoSitePlus

Other Protein References for KIF4A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KIF4A Gene

Domains for KIF4A Gene

Gene Families for KIF4A Gene

HGNC:
  • KIF :Kinesins

Protein Domains for KIF4A Gene

Suggested Antigen Peptide Sequences for KIF4A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95239

UniProtKB/Swiss-Prot:

KIF4A_HUMAN :
  • O95239
Domain:
  • Contains 1 kinesin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Chromokinesin subfamily.
genes like me logo Genes that share domains with KIF4A: view

Function for KIF4A Gene

Molecular function for KIF4A Gene

UniProtKB/Swiss-Prot Function: Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization.

Gene Ontology (GO) - Molecular Function for KIF4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003777 microtubule motor activity TAS 7929562
GO:0005515 protein binding IPI 16431929
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
genes like me logo Genes that share ontologies with KIF4A: view

Phenotypes for KIF4A Gene

MGI mutant phenotypes for KIF4A:
inferred from 1 alleles
GenomeRNAi human phenotypes for KIF4A:
genes like me logo Genes that share phenotypes with KIF4A: view

Animal Model Products

CRISPR Products

miRNA for KIF4A Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KIF4A Gene

Localization for KIF4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF4A Gene

Nucleus matrix. Cytoplasm, cytoskeleton, spindle. Midbody. Chromosome. Note=Not present in the nucleolus. In early mitosis, associated with the mitotic spindle, in anaphase, localized to the spindle midzone and, in telophase and cytokinesis, to the midbody. In late cytokinesis, found in the center of the midbody. Associated with chromosomes at all stages of mitosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIF4A Gene COMPARTMENTS Subcellular localization image for KIF4A gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for KIF4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005694 chromosome IEA --
GO:0005737 cytoplasm TAS 7929562
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with KIF4A: view

Pathways for KIF4A Gene

genes like me logo Genes that share pathways with KIF4A: view

Pathways by source for KIF4A Gene

1 BioSystems pathway for KIF4A Gene

Gene Ontology (GO) - Biological Process for KIF4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000281 mitotic cytokinesis IMP 15843429
GO:0006200 obsolete ATP catabolic process --
GO:0006996 organelle organization TAS 7929562
GO:0007018 microtubule-based movement TAS --
GO:0007411 axon guidance TAS --
genes like me logo Genes that share ontologies with KIF4A: view

Transcripts for KIF4A Gene

mRNA/cDNA for KIF4A Gene

Unigene Clusters for KIF4A Gene

Kinesin family member 4A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIF4A

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KIF4A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF4A Gene

No ASD Table

Relevant External Links for KIF4A Gene

GeneLoc Exon Structure for
KIF4A
ECgene alternative splicing isoforms for
KIF4A

Expression for KIF4A Gene

mRNA expression in normal human tissues for KIF4A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIF4A Gene

SOURCE GeneReport for Unigene cluster for KIF4A Gene Hs.648326

mRNA Expression by UniProt/SwissProt for KIF4A Gene

O95239-KIF4A_HUMAN
Tissue specificity: Highly expressed in hematopoietic tissues, fetal liver, spleen, thymus and adult thymus and bone marrow. Lower levels are found in heart, testis, kidney, colon and lung.
genes like me logo Genes that share expressions with KIF4A: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for KIF4A Gene

Orthologs for KIF4A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KIF4A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF4A 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 93 (a)
OneToMany
KIF4A 35
  • 91.83 (n)
  • 93.1 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 95 (a)
OneToMany
KIF4A 35
  • 92.91 (n)
  • 95.05 (a)
mouse
(Mus musculus)
Mammalia Kif4 35
  • 86.68 (n)
  • 87.31 (a)
Kif4 16
Kif4 36
  • 87 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 81 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Kif4a 35
  • 86.63 (n)
  • 86.74 (a)
chicken
(Gallus gallus)
Aves KIF4A 35
  • 72.82 (n)
  • 76.66 (a)
KIF4A 36
  • 75 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 59 (a)
ManyToMany
-- 36
  • 67 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia kif4a-A-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia kif4a 35
  • 68.94 (n)
  • 71.82 (a)
zebrafish
(Danio rerio)
Actinopterygii KIF4A 36
  • 62 (a)
OneToMany
zgc66125 35
zgc:66125 35
  • 63.52 (n)
  • 63.77 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012471 35
  • 50.39 (n)
  • 48.26 (a)
fruit fly
(Drosophila melanogaster)
Insecta Klp3A 35
  • 47.8 (n)
  • 40.21 (a)
Klp3A 36
  • 34 (a)
OneToMany
nod 37
  • 35 (a)
Klp3A 37
  • 36 (a)
Kif19A 37
  • 38 (a)
worm
(Caenorhabditis elegans)
Secernentea klp-19 35
  • 46.42 (n)
  • 37.2 (a)
klp-19 36
  • 33 (a)
OneToMany
klp-19 37
  • 32 (a)
klp-10 37
  • 27 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G60930 35
  • 50.65 (n)
  • 42.09 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToMany
Species with no ortholog for KIF4A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIF4A Gene

ENSEMBL:
Gene Tree for KIF4A (if available)
TreeFam:
Gene Tree for KIF4A (if available)

Paralogs for KIF4A Gene

Selected SIMAP similar genes for KIF4A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KIF4A: view

Variants for KIF4A Gene

Sequence variations from dbSNP and Humsavar for KIF4A Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs438206 -- 70,367,918(+) cacat(A/G)gtccc intron-variant
rs946450 -- 70,292,813(-) AGAAT(A/G)TAAAA intron-variant
rs1046485 - 70,420,144(+) AGAGT(C/T)GAAAC missense, reference
rs1046487 -- 70,420,153(+) ACATG(G/T)AGCAA missense, reference
rs1046488 -- 70,420,170(+) ACCAA(C/G)AAAAC missense, reference

Structural Variations from Database of Genomic Variants (DGV) for KIF4A Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER Inversion 17803354
esv1361658 CNV Insertion 17803354
nsv425219 CNV Loss 16902084
esv2740208 CNV Deletion 23290073
nsv6950 CNV Insertion 18451855
esv33082 CNV Loss 17666407

Relevant External Links for KIF4A Gene

HapMap Linkage Disequilibrium report
KIF4A
Human Gene Mutation Database (HGMD)
KIF4A
Locus Specific Mutation Databases (LSDB)
KIF4A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF4A Gene

Disorders for KIF4A Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for KIF4A Gene including...

Search for KIF4A Gene in MalaCards »

(2) Novoseek inferred disease relationships for KIF4A Gene

Disease -log(P) Hits PubMed IDs
retinoblastoma 29 3
tumors 0 1
genes like me logo Genes that share disorders with KIF4A: view

No data available for UniProtKB/Swiss-Prot for KIF4A Gene

Publications for KIF4A Gene

  1. Increased chromokinesin immunoreactivity in retinoblastoma cells. (PMID: 9168136) Yan R.-T. … Wang S.-Z. (Gene 1997) 3 4 23
  2. Human kinesin superfamily member 4 is dominantly localized in the nuclear matrix and is associated with chromosomes during mitosis. (PMID: 11736643) Lee Y.M. … Kim W. (Biochem. J. 2001) 3 4 23
  3. Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation. (PMID: 15297875) Kurasawa Y. … Todokoro K. (EMBO J. 2004) 3 4 23
  4. Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis. (PMID: 15625105) Zhu C. … Jiang W. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 4 23
  5. Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference. (PMID: 15843429) Zhu C. … Jiang W. (Mol. Biol. Cell 2005) 3 23

Products for KIF4A Gene

Sources for KIF4A Gene

Back to Top

Content