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Aliases for KIF3C Gene

Aliases for KIF3C Gene

  • Kinesin Family Member 3C 2 3 5

External Ids for KIF3C Gene

Previous GeneCards Identifiers for KIF3C Gene

  • GC02M026070
  • GC02M026242
  • GC02M026124
  • GC02M026061
  • GC02M026002
  • GC02M026149
  • GC02M025888

Summaries for KIF3C Gene

GeneCards Summary for KIF3C Gene

KIF3C (Kinesin Family Member 3C) is a Protein Coding gene. Among its related pathways are Platelet activation, signaling and aggregation and Immune System. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF14.

UniProtKB/Swiss-Prot for KIF3C Gene

  • Microtubule-based anterograde translocator for membranous organelles.

Gene Wiki entry for KIF3C Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF3C Gene

Genomics for KIF3C Gene

Regulatory Elements for KIF3C Gene

Promoters for KIF3C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KIF3C on UCSC Golden Path with GeneCards custom track

Genomic Location for KIF3C Gene

Chromosome:
2
Start:
25,926,586 bp from pter
End:
25,982,749 bp from pter
Size:
56,164 bases
Orientation:
Minus strand

Genomic View for KIF3C Gene

Genes around KIF3C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF3C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF3C Gene

Proteins for KIF3C Gene

  • Protein details for KIF3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14782-KIF3C_HUMAN
    Recommended name:
    Kinesin-like protein KIF3C
    Protein Accession:
    O14782
    Secondary Accessions:
    • O43544
    • Q4ZG18
    • Q53SX5
    • Q562F7

    Protein attributes for KIF3C Gene

    Size:
    793 amino acids
    Molecular mass:
    89426 Da
    Quaternary structure:
    • Heterodimer of KIF3A and KIF3C.

    Three dimensional structures from OCA and Proteopedia for KIF3C Gene

neXtProt entry for KIF3C Gene

Proteomics data for KIF3C Gene at MOPED

Post-translational modifications for KIF3C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIF3C Gene

Antibody Products

No data available for DME Specific Peptides for KIF3C Gene

Domains & Families for KIF3C Gene

Gene Families for KIF3C Gene

Protein Domains for KIF3C Gene

Suggested Antigen Peptide Sequences for KIF3C Gene

Graphical View of Domain Structure for InterPro Entry

O14782

UniProtKB/Swiss-Prot:

KIF3C_HUMAN :
  • Contains 1 kinesin motor domain.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.
Domain:
  • Contains 1 kinesin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.
genes like me logo Genes that share domains with KIF3C: view

Function for KIF3C Gene

Molecular function for KIF3C Gene

GENATLAS Biochemistry:
kinesin heavy chain member 3C,microtubule associated motor protein,ATP dependent superfamily,anterograde heterodimerizing motor,one transcript specifically expressed in brain,other ubiquitous
UniProtKB/Swiss-Prot Function:
Microtubule-based anterograde translocator for membranous organelles.

Gene Ontology (GO) - Molecular Function for KIF3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0016887 ATPase activity IBA --
genes like me logo Genes that share ontologies with KIF3C: view
genes like me logo Genes that share phenotypes with KIF3C: view

Animal Models for KIF3C Gene

MGI Knock Outs for KIF3C:

Animal Model Products

miRNA for KIF3C Gene

miRTarBase miRNAs that target KIF3C

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KIF3C Gene

Localization for KIF3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF3C Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIF3C Gene COMPARTMENTS Subcellular localization image for KIF3C gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 2
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for KIF3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0097542 ciliary tip TAS --
genes like me logo Genes that share ontologies with KIF3C: view

Pathways & Interactions for KIF3C Gene

genes like me logo Genes that share pathways with KIF3C: view

Gene Ontology (GO) - Biological Process for KIF3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007018 microtubule-based movement IEA,TAS --
GO:0007596 blood coagulation TAS --
genes like me logo Genes that share ontologies with KIF3C: view

No data available for SIGNOR curated interactions for KIF3C Gene

Drugs & Compounds for KIF3C Gene

No Compound Related Data Available

Transcripts for KIF3C Gene

Unigene Clusters for KIF3C Gene

Kinesin family member 3C:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF3C Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1: -
SP2:
SP3: -
SP4:

Relevant External Links for KIF3C Gene

GeneLoc Exon Structure for
KIF3C
ECgene alternative splicing isoforms for
KIF3C

Expression for KIF3C Gene

mRNA expression in normal human tissues for KIF3C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIF3C Gene

This gene is overexpressed in Brain - Cortex (x5.9), Brain - Frontal Cortex (BA9) (x5.9), and Brain - Anterior cingulate cortex (BA24) (x5.5).

Protein differential expression in normal tissues from HIPED for KIF3C Gene

This gene is overexpressed in Brain (38.1), Cervix (9.9), and Bone (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIF3C Gene



SOURCE GeneReport for Unigene cluster for KIF3C Gene Hs.21611

genes like me logo Genes that share expression patterns with KIF3C: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for KIF3C Gene

Orthologs for KIF3C Gene

This gene was present in the common ancestor of animals.

Orthologs for KIF3C Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KIF3C 35
  • 91.28 (n)
  • 95.83 (a)
KIF3C 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIF3C 35
  • 92.81 (n)
  • 97.1 (a)
KIF3C 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kif3c 35
  • 89.49 (n)
  • 95.21 (a)
Kif3c 16
Kif3c 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KIF3C 35
  • 99.54 (n)
  • 99.87 (a)
KIF3C 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kif3c 35
  • 89.79 (n)
  • 96.22 (a)
oppossum
(Monodelphis domestica)
Mammalia KIF3C 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF3C 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIF3C 35
  • 80.59 (n)
  • 84.74 (a)
KIF3C 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kif3c 35
  • 73.7 (n)
  • 80.24 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.29546 35
kif3cb 35
  • 63.58 (n)
  • 64.09 (a)
CABZ01076801.1 36
  • 75 (a)
OneToMany
kif3cb 36
  • 61 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2897 35
fruit fly
(Drosophila melanogaster)
Insecta Kif3C 37
  • 34 (a)
Klp68D 37
  • 42 (a)
Klp68D 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea klp-11 37
  • 48 (a)
osm-3 37
  • 37 (a)
klp-11 36
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
OneToMany
Species with no ortholog for KIF3C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIF3C Gene

ENSEMBL:
Gene Tree for KIF3C (if available)
TreeFam:
Gene Tree for KIF3C (if available)

Paralogs for KIF3C Gene

genes like me logo Genes that share paralogs with KIF3C: view

Variants for KIF3C Gene

Sequence variations from dbSNP and Humsavar for KIF3C Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1465878 - 25,980,809(-) GCCCC(A/G)GGTGA reference, missense
rs1061449 -- 25,927,705(-) GCAAG(C/T)GAGTG utr-variant-3-prime
rs1061485 -- 25,926,633(-) ATCAA(C/T)GCAGT utr-variant-3-prime
rs1062937 -- 25,980,505(-) GAGGA(G/T)AAGGC reference, missense
rs1139892 -- 25,954,268(-) AGCTC(A/G)AGTAC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for KIF3C Gene

Variant ID Type Subtype PubMed ID
esv33316 CNV Loss 17666407
nsv873744 CNV Loss 21882294
nsv873745 CNV Gain 21882294
nsv873746 CNV Gain 21882294
esv2659098 CNV Deletion 23128226
nsv215114 CNV Loss 16902084

Variation tolerance for KIF3C Gene

Residual Variation Intolerance Score: 15.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.31; 41.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIF3C Gene

HapMap Linkage Disequilibrium report
KIF3C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF3C Gene

Disorders for KIF3C Gene

Relevant External Links for KIF3C

Genetic Association Database (GAD)
KIF3C
Human Genome Epidemiology (HuGE) Navigator
KIF3C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIF3C

No disorders were found for KIF3C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIF3C Gene

Publications for KIF3C Gene

  1. KIF3C, a novel member of the kinesin superfamily: sequence, expression, and mapping to human chromosome 2 at 2p23. (PMID: 9480755) Sardella M. … Cabibbo A. (Genomics 1998) 2 3 4 23 67
  2. Identification of host proteins required for HIV infection through a functional genomic screen. (PMID: 18187620) Brass A.L. … Elledge S.J. (Science 2008) 3
  3. Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. (PMID: 17043677) Camargo L.M. … Brandon N.J. (Mol. Psychiatry 2007) 3
  4. The fragile X mental retardation protein is a molecular adaptor between the neurospecific KIF3C kinesin and dendritic RNA granules. (PMID: 17881655) Davidovic L. … Khandjian E.W. (Hum. Mol. Genet. 2007) 3
  5. Kinesin superfamily protein-derived peptides with the ability to induce glioma-reactive cytotoxic T lymphocytes in human leukocyte antigen-A24+ glioma patients. (PMID: 17273744) Harada M. … Yamanaka R. (Oncol. Rep. 2007) 23

Products for KIF3C Gene

Sources for KIF3C Gene

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