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Aliases for KIF3C Gene

Aliases for KIF3C Gene

  • Kinesin Family Member 3C 2 3

External Ids for KIF3C Gene

Previous GeneCards Identifiers for KIF3C Gene

  • GC02M026070
  • GC02M026242
  • GC02M026124
  • GC02M026061
  • GC02M026002
  • GC02M026149
  • GC02M025888

Summaries for KIF3C Gene

GeneCards Summary for KIF3C Gene

KIF3C (Kinesin Family Member 3C) is a Protein Coding gene. Diseases associated with KIF3C include benign glioma. Among its related pathways are Class I MHC mediated antigen processing and presentation and Hemostasis. GO annotations related to this gene include microtubule binding and motor activity. An important paralog of this gene is KIF5C.

UniProtKB/Swiss-Prot for KIF3C Gene

  • Microtubule-based anterograde translocator for membranous organelles.

Gene Wiki entry for KIF3C Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF3C Gene

Genomics for KIF3C Gene

Regulatory Elements for KIF3C Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KIF3C Gene

Start:
25,926,586 bp from pter
End:
25,982,749 bp from pter
Size:
56,164 bases
Orientation:
Minus strand

Genomic View for KIF3C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIF3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF3C Gene

Proteins for KIF3C Gene

  • Protein details for KIF3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14782-KIF3C_HUMAN
    Recommended name:
    Kinesin-like protein KIF3C
    Protein Accession:
    O14782
    Secondary Accessions:
    • O43544
    • Q4ZG18
    • Q53SX5
    • Q562F7

    Protein attributes for KIF3C Gene

    Size:
    793 amino acids
    Molecular mass:
    89426 Da
    Quaternary structure:
    • Heterodimer of KIF3A and KIF3C.

    Three dimensional structures from OCA and Proteopedia for KIF3C Gene

neXtProt entry for KIF3C Gene

Proteomics data for KIF3C Gene at MOPED

Post-translational modifications for KIF3C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIF3C Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KIF3C Gene

Domains for KIF3C Gene

Gene Families for KIF3C Gene

HGNC:
  • KIF :Kinesins

Protein Domains for KIF3C Gene

Suggested Antigen Peptide Sequences for KIF3C Gene

Graphical View of Domain Structure for InterPro Entry

O14782

UniProtKB/Swiss-Prot:

KIF3C_HUMAN :
  • O14782
Domain:
  • Contains 1 kinesin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.
genes like me logo Genes that share domains with KIF3C: view

Function for KIF3C Gene

Molecular function for KIF3C Gene

GENATLAS Biochemistry: kinesin heavy chain member 3C,microtubule associated motor protein,ATP dependent superfamily,anterograde heterodimerizing motor,one transcript specifically expressed in brain,other ubiquitous
UniProtKB/Swiss-Prot Function: Microtubule-based anterograde translocator for membranous organelles.

Gene Ontology (GO) - Molecular Function for KIF3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity TAS 9480755
GO:0003777 microtubule motor activity IBA --
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
genes like me logo Genes that share ontologies with KIF3C: view
genes like me logo Genes that share phenotypes with KIF3C: view

Animal Models for KIF3C Gene

MGI Knock Outs for KIF3C:

Animal Model Products

CRISPR Products

miRNA for KIF3C Gene

miRTarBase miRNAs that target KIF3C

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIF3C

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for KIF3C Gene

Localization for KIF3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF3C Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIF3C Gene COMPARTMENTS Subcellular localization image for KIF3C gene
Compartment Confidence
cytoskeleton 4
cytosol 4
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KIF3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005871 kinesin complex IBA --
GO:0005874 microtubule IEA --
GO:0072372 primary cilium TAS --
GO:0097542 ciliary tip TAS --
genes like me logo Genes that share ontologies with KIF3C: view

Pathways for KIF3C Gene

genes like me logo Genes that share pathways with KIF3C: view

Gene Ontology (GO) - Biological Process for KIF3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006996 organelle organization TAS --
GO:0007018 microtubule-based movement TAS --
GO:0007596 blood coagulation TAS --
GO:0008152 metabolic process TAS 9480755
genes like me logo Genes that share ontologies with KIF3C: view

Transcripts for KIF3C Gene

Unigene Clusters for KIF3C Gene

Kinesin family member 3C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIF3C

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KIF3C

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF3C Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1: -
SP2:
SP3: -
SP4:

Relevant External Links for KIF3C Gene

GeneLoc Exon Structure for
KIF3C
ECgene alternative splicing isoforms for
KIF3C

Expression for KIF3C Gene

mRNA expression in normal human tissues for KIF3C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIF3C Gene

This gene is overexpressed in Brain - Cortex (5.9), Brain - Frontal Cortex (BA9) (5.9), and Brain - Anterior cingulate cortex (BA24) (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIF3C Gene

SOURCE GeneReport for Unigene cluster for KIF3C Gene Hs.21611

genes like me logo Genes that share expressions with KIF3C: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for KIF3C Gene

Orthologs for KIF3C Gene

This gene was present in the common ancestor of animals.

Orthologs for KIF3C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF3C 35
  • 99.54 (n)
  • 99.87 (a)
KIF3C 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIF3C 35
  • 91.28 (n)
  • 95.83 (a)
KIF3C 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIF3C 35
  • 92.81 (n)
  • 97.1 (a)
KIF3C 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kif3c 35
  • 89.49 (n)
  • 95.21 (a)
Kif3c 16
Kif3c 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIF3C 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF3C 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kif3c 35
  • 89.79 (n)
  • 96.22 (a)
chicken
(Gallus gallus)
Aves KIF3C 35
  • 80.59 (n)
  • 84.74 (a)
KIF3C 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kif3c 35
  • 73.7 (n)
  • 80.24 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2897 35
zebrafish
(Danio rerio)
Actinopterygii CABZ01076801.1 36
  • 75 (a)
OneToMany
Dr.29546 35
kif3cb 35
  • 63.58 (n)
  • 64.09 (a)
kif3cb 36
  • 61 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Klp68D 36
  • 41 (a)
OneToMany
Klp68D 37
  • 42 (a)
Kif3C 37
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea klp-11 36
  • 31 (a)
OneToMany
klp-11 37
  • 48 (a)
osm-3 37
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
OneToMany
Species with no ortholog for KIF3C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIF3C Gene

ENSEMBL:
Gene Tree for KIF3C (if available)
TreeFam:
Gene Tree for KIF3C (if available)

Paralogs for KIF3C Gene

genes like me logo Genes that share paralogs with KIF3C: view

Variants for KIF3C Gene

Sequence variations from dbSNP and Humsavar for KIF3C Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1061449 -- 25,927,705(-) GCAAG(C/T)GAGTG utr-variant-3-prime
rs1061485 -- 25,926,633(-) ATCAA(C/T)GCAGT utr-variant-3-prime
rs1062937 -- 25,980,505(-) GAGGA(G/T)AAGGC reference, missense
rs1139892 -- 25,954,268(-) AGCTC(A/G)AGTAC reference, missense
rs1465877 -- 25,982,212(-) GCTCC(A/T)GCATG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for KIF3C Gene

Variant ID Type Subtype PubMed ID
esv33316 CNV Loss 17666407
nsv873744 CNV Loss 21882294
nsv873745 CNV Gain 21882294
nsv873746 CNV Gain 21882294
esv2659098 CNV Deletion 23128226
nsv215114 CNV Loss 16902084

Relevant External Links for KIF3C Gene

HapMap Linkage Disequilibrium report
KIF3C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF3C Gene

Disorders for KIF3C Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for KIF3C Gene including...

Search for KIF3C Gene in MalaCards »

(1) University of Copenhagen DISEASES for KIF3C Gene

Relevant External Links for KIF3C

Genetic Association Database (GAD)
KIF3C
Human Genome Epidemiology (HuGE) Navigator
KIF3C
genes like me logo Genes that share disorders with KIF3C: view

No data available for UniProtKB/Swiss-Prot for KIF3C Gene

Publications for KIF3C Gene

  1. KIF3C, a novel member of the kinesin superfamily: sequence, expression, and mapping to human chromosome 2 at 2p23. (PMID: 9480755) Sardella M. … Cabibbo A. (Genomics 1998) 2 3 4 23
  2. cDNA cloning, genomic organization, and chromosomal localization of a novel human gene that encodes a kinesin-related protein highly similar to mouse Kif3C. (PMID: 9446808) Telford E.A.R. … Bonthron D.T. (Biochem. Biophys. Res. Commun. 1998) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. (PMID: 17043677) Camargo L.M. … Brandon N.J. (Mol. Psychiatry 2007) 3

Products for KIF3C Gene

  • Addgene plasmids for KIF3C

Sources for KIF3C Gene

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