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Aliases for KIF3C Gene

Aliases for KIF3C Gene

  • Kinesin Family Member 3C 2 3 5

External Ids for KIF3C Gene

Previous GeneCards Identifiers for KIF3C Gene

  • GC02M026070
  • GC02M026242
  • GC02M026124
  • GC02M026061
  • GC02M026002
  • GC02M026149
  • GC02M025888

Summaries for KIF3C Gene

GeneCards Summary for KIF3C Gene

KIF3C (Kinesin Family Member 3C) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Golgi-to-ER retrograde transport. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF3B.

UniProtKB/Swiss-Prot for KIF3C Gene

  • Microtubule-based anterograde translocator for membranous organelles.

Gene Wiki entry for KIF3C Gene

Additional gene information for KIF3C Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF3C Gene

Genomics for KIF3C Gene

Regulatory Elements for KIF3C Gene

Enhancers for KIF3C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H026011 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -29.8 -29808 3 PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 YY1 FOS DEK SP3 RAB10 RNU6-942P KIF3C SLC35F6 GAREM2 TRMT112P6 GC02P025994
GH02H026017 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.2 -35.6 -35644 2 PKNOX1 SIN3A YY1 GLIS2 FOS ATF7 REST ZNF592 SREBF1 MAFF RNU6-942P KIF3C RAB10 GAREM2 TRMT112P6 GC02P025994
GH02H025876 1.1 ENCODE 19.3 +104.4 104398 2 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 KIF3C ASXL2 DTNB GC02M025821
GH02H025951 1.2 ENCODE dbSUPER 17.2 +31.5 31533 0 PKNOX1 ARID4B SIN3A ZNF2 YY1 ZNF143 RUNX3 DEK SP5 MXD4 KIF3C RAB10 RNU6-942P NDUFB4P4
GH02H026007 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.4 -26.3 -26252 2 TBP PKNOX1 KLF1 NFIB TAL1 MAX SIN3A DNMT3B TCF12 ZNF316 RAB10 RNU6-942P KIF3C GAREM2 GC02P025994 TRMT112P6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KIF3C on UCSC Golden Path with GeneCards custom track

Promoters for KIF3C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000114238 149 1201 PKNOX1 ATF1 ARID4B SIN3A ETS1 GLIS2 ZNF143 ATF7 SP3 SP5

Genomic Location for KIF3C Gene

Chromosome:
2
Start:
25,926,586 bp from pter
End:
25,982,749 bp from pter
Size:
56,164 bases
Orientation:
Minus strand

Genomic View for KIF3C Gene

Genes around KIF3C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF3C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF3C Gene

Proteins for KIF3C Gene

  • Protein details for KIF3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14782-KIF3C_HUMAN
    Recommended name:
    Kinesin-like protein KIF3C
    Protein Accession:
    O14782
    Secondary Accessions:
    • O43544
    • Q4ZG18
    • Q53SX5
    • Q562F7

    Protein attributes for KIF3C Gene

    Size:
    793 amino acids
    Molecular mass:
    89426 Da
    Quaternary structure:
    • Heterodimer of KIF3A and KIF3C.

    Three dimensional structures from OCA and Proteopedia for KIF3C Gene

neXtProt entry for KIF3C Gene

Post-translational modifications for KIF3C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIF3C Gene

No data available for DME Specific Peptides for KIF3C Gene

Domains & Families for KIF3C Gene

Gene Families for KIF3C Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for KIF3C Gene

Suggested Antigen Peptide Sequences for KIF3C Gene

Graphical View of Domain Structure for InterPro Entry

O14782

UniProtKB/Swiss-Prot:

KIF3C_HUMAN :
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.
genes like me logo Genes that share domains with KIF3C: view

Function for KIF3C Gene

Molecular function for KIF3C Gene

GENATLAS Biochemistry:
kinesin heavy chain member 3C,microtubule associated motor protein,ATP dependent superfamily,anterograde heterodimerizing motor,one transcript specifically expressed in brain,other ubiquitous
UniProtKB/Swiss-Prot Function:
Microtubule-based anterograde translocator for membranous organelles.

Phenotypes From GWAS Catalog for KIF3C Gene

Gene Ontology (GO) - Molecular Function for KIF3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity TAS 9480755
GO:0003777 microtubule motor activity IBA --
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
GO:0016887 ATPase activity IBA --
genes like me logo Genes that share ontologies with KIF3C: view
genes like me logo Genes that share phenotypes with KIF3C: view

Animal Models for KIF3C Gene

MGI Knock Outs for KIF3C:

Animal Model Products

CRISPR Products

miRNA for KIF3C Gene

miRTarBase miRNAs that target KIF3C

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for KIF3C
  • Applied Biological Materials Clones for KIF3C
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KIF3C Gene

Localization for KIF3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF3C Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIF3C gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 2
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (2)
  • Nuclear bodies (2)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KIF3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005871 kinesin complex TAS 9480755
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with KIF3C: view

Pathways & Interactions for KIF3C Gene

genes like me logo Genes that share pathways with KIF3C: view

Gene Ontology (GO) - Biological Process for KIF3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS --
GO:0007018 microtubule-based movement TAS --
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
GO:0035735 intraciliary transport involved in cilium assembly TAS --
GO:0072384 organelle transport along microtubule IEA --
genes like me logo Genes that share ontologies with KIF3C: view

No data available for SIGNOR curated interactions for KIF3C Gene

Drugs & Compounds for KIF3C Gene

No Compound Related Data Available

Transcripts for KIF3C Gene

Unigene Clusters for KIF3C Gene

Kinesin family member 3C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for KIF3C
  • Applied Biological Materials Clones for KIF3C
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for KIF3C Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1: -
SP2:
SP3: -
SP4:

Relevant External Links for KIF3C Gene

GeneLoc Exon Structure for
KIF3C
ECgene alternative splicing isoforms for
KIF3C

Expression for KIF3C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIF3C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIF3C Gene

This gene is overexpressed in Brain - Cortex (x5.9), Brain - Frontal Cortex (BA9) (x5.9), and Brain - Anterior cingulate cortex (BA24) (x5.5).

Protein differential expression in normal tissues from HIPED for KIF3C Gene

This gene is overexpressed in Brain (38.1), Cervix (9.9), and Bone (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KIF3C Gene



NURSA nuclear receptor signaling pathways regulating expression of KIF3C Gene:

KIF3C

SOURCE GeneReport for Unigene cluster for KIF3C Gene:

Hs.21611

Evidence on tissue expression from TISSUES for KIF3C Gene

  • Nervous system(4.5)
  • Eye(2.3)
genes like me logo Genes that share expression patterns with KIF3C: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIF3C Gene

Orthologs for KIF3C Gene

This gene was present in the common ancestor of animals.

Orthologs for KIF3C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF3C 33 34
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia KIF3C 33 34
  • 92.81 (n)
oppossum
(Monodelphis domestica)
Mammalia KIF3C 34
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIF3C 33 34
  • 91.28 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KIF3C 34
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kif3c 33
  • 89.79 (n)
mouse
(Mus musculus)
Mammalia Kif3c 33 16 34
  • 89.49 (n)
chicken
(Gallus gallus)
Aves KIF3C 33 34
  • 80.59 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia kif3c 33
  • 73.7 (n)
zebrafish
(Danio rerio)
Actinopterygii CABZ01076801.1 34
  • 75 (a)
OneToMany
kif3cb 33 34
  • 63.58 (n)
Dr.29546 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2897 33
fruit fly
(Drosophila melanogaster)
Insecta Klp68D 35 34
  • 42 (a)
Kif3C 35
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea klp-11 35 34
  • 48 (a)
osm-3 35
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 54 (a)
OneToMany
Species where no ortholog for KIF3C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIF3C Gene

ENSEMBL:
Gene Tree for KIF3C (if available)
TreeFam:
Gene Tree for KIF3C (if available)

Paralogs for KIF3C Gene

Paralogs for KIF3C Gene

genes like me logo Genes that share paralogs with KIF3C: view

Variants for KIF3C Gene

Sequence variations from dbSNP and Humsavar for KIF3C Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000021171 -- 25,984,036(+) CTTCT(C/T)CACAG upstream-variant-2KB
rs1000053052 -- 25,952,998(+) GCGAG(A/G)TGGCT intron-variant
rs1000115549 -- 25,961,019(+) TCCTA(C/T)TGCAG intron-variant
rs1000125946 -- 25,952,793(+) CCTCA(C/G)GTGAT intron-variant
rs1000169939 -- 25,975,431(+) TGCTG(G/T)GATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF3C Gene

Variant ID Type Subtype PubMed ID
esv2659098 CNV deletion 23128226
esv33316 CNV loss 17666407
esv3554066 CNV deletion 23714750
nsv1123305 CNV deletion 24896259
nsv215114 CNV deletion 16902084

Variation tolerance for KIF3C Gene

Residual Variation Intolerance Score: 15.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.31; 41.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIF3C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIF3C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF3C Gene

Disorders for KIF3C Gene

Relevant External Links for KIF3C

Genetic Association Database (GAD)
KIF3C
Human Genome Epidemiology (HuGE) Navigator
KIF3C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIF3C

No disorders were found for KIF3C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIF3C Gene

Publications for KIF3C Gene

  1. KIF3C, a novel member of the kinesin superfamily: sequence, expression, and mapping to human chromosome 2 at 2p23. (PMID: 9480755) Sardella M … Cabibbo A (Genomics 1998) 2 3 4 22 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. cDNA cloning, genomic organization, and chromosomal localization of a novel human gene that encodes a kinesin-related protein highly similar to mouse Kif3C. (PMID: 9446808) Telford EA … Bonthron DT (Biochemical and biophysical research communications 1998) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 60

Products for KIF3C Gene

  • Addgene plasmids for KIF3C

Sources for KIF3C Gene

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