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Aliases for KIF3B Gene

Aliases for KIF3B Gene

  • Kinesin Family Member 3B 2 3 5
  • Microtubule Plus End-Directed Kinesin Motor 3B 3 4
  • HH0048 3 4
  • KIAA0359 4
  • KLP-11 3
  • FLA8 3

External Ids for KIF3B Gene

Previous GeneCards Identifiers for KIF3B Gene

  • GC20P030653
  • GC20P031564
  • GC20P031610
  • GC20P030329
  • GC20P030865
  • GC20P027653

Summaries for KIF3B Gene

Entrez Gene Summary for KIF3B Gene

  • The protein encoded by this gene acts as a heterodimer with kinesin family member 3A to aid in chromosome movement during mitosis and meiosis. The encoded protein is a plus end-directed microtubule motor and can interact with the SMC3 subunit of the cohesin complex. In addition, the encoded protein may be involved in the intracellular movement of membranous organelles. This protein and kinesin family member 3A form the kinesin II subfamily of the kinesin superfamily. [provided by RefSeq, Jul 2008]

GeneCards Summary for KIF3B Gene

KIF3B (Kinesin Family Member 3B) is a Protein Coding gene. Diseases associated with KIF3B include Tuberculous Peritonitis and Corneal Dystrophy, Posterior Polymorphous, 1. Among its related pathways are Golgi-to-ER retrograde transport and Immune System. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF14.

UniProtKB/Swiss-Prot for KIF3B Gene

  • Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity).

Gene Wiki entry for KIF3B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF3B Gene

Genomics for KIF3B Gene

Regulatory Elements for KIF3B Gene

Enhancers for KIF3B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KIF3B on UCSC Golden Path with GeneCards custom track

Promoters for KIF3B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KIF3B on UCSC Golden Path with GeneCards custom track

Genomic Location for KIF3B Gene

Chromosome:
20
Start:
32,277,651 bp from pter
End:
32,335,011 bp from pter
Size:
57,361 bases
Orientation:
Plus strand

Genomic View for KIF3B Gene

Genes around KIF3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF3B Gene

Proteins for KIF3B Gene

  • Protein details for KIF3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15066-KIF3B_HUMAN
    Recommended name:
    Kinesin-like protein KIF3B
    Protein Accession:
    O15066
    Secondary Accessions:
    • B2RMP4
    • B4DSR5
    • E1P5M5

    Protein attributes for KIF3B Gene

    Size:
    747 amino acids
    Molecular mass:
    85125 Da
    Quaternary structure:
    • Heterodimer of KIF3A and KIF3B. Interacts directly with IFT20 (By similarity). Interacts with the SMC3 subunit of the cohesin complex.
    SequenceCaution:
    • Sequence=BAA20815.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KIF3B Gene

    Alternative splice isoforms for KIF3B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF3B Gene

Proteomics data for KIF3B Gene at MOPED

Post-translational modifications for KIF3B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIF3B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for KIF3B (KIF3B)

No data available for DME Specific Peptides for KIF3B Gene

Domains & Families for KIF3B Gene

Gene Families for KIF3B Gene

Protein Domains for KIF3B Gene

Suggested Antigen Peptide Sequences for KIF3B Gene

Graphical View of Domain Structure for InterPro Entry

O15066

UniProtKB/Swiss-Prot:

KIF3B_HUMAN :
  • Contains 1 kinesin motor domain.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.
Domain:
  • Contains 1 kinesin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.
genes like me logo Genes that share domains with KIF3B: view

Function for KIF3B Gene

Molecular function for KIF3B Gene

GENATLAS Biochemistry:
kinesin family 3 member B,cDNA sequence,expressed in brain,>100kDa,homolog to murine kinesin KIF3B
UniProtKB/Swiss-Prot Function:
Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity).

Gene Ontology (GO) - Molecular Function for KIF3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008017 microtubule binding IEA --
genes like me logo Genes that share ontologies with KIF3B: view
genes like me logo Genes that share phenotypes with KIF3B: view

Animal Models for KIF3B Gene

MGI Knock Outs for KIF3B:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KIF3B Gene

Localization for KIF3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF3B Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIF3B Gene COMPARTMENTS Subcellular localization image for KIF3B gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
nucleus 4
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for KIF3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005873 plus-end kinesin complex TAS 7559760
GO:0016020 membrane IDA 19946888
GO:0030496 midbody IEA --
GO:0030990 intraciliary transport particle IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with KIF3B: view

Pathways & Interactions for KIF3B Gene

genes like me logo Genes that share pathways with KIF3B: view

Gene Ontology (GO) - Biological Process for KIF3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0007052 mitotic spindle organization TAS 16298999
GO:0008152 metabolic process IEA --
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
GO:0032467 positive regulation of cytokinesis IEA --
genes like me logo Genes that share ontologies with KIF3B: view

No data available for SIGNOR curated interactions for KIF3B Gene

Drugs & Compounds for KIF3B Gene

(3) Drugs for KIF3B Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
GSK-923295 Investigational Pharma CENP-E inhibitor,small-molecule, Kinesin protein inhibitors 0
MPI-0479605 Pharma Mps1 inhibitor,selective and ATP competitive 0
SB743921 Pharma Potent KSP inhibitor 0

(3) ApexBio Compounds for KIF3B Gene

Compound Action Cas Number
GSK-923295 CENP-E inhibitor,small-molecule 1088965-37-0
MPI-0479605 Mps1 inhibitor,selective and ATP competitive 1246529-32-7
SB743921 Potent KSP inhibitor 940929-33-9
genes like me logo Genes that share compounds with KIF3B: view

Transcripts for KIF3B Gene

mRNA/cDNA for KIF3B Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(303) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KIF3B Gene

Kinesin family member 3B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIF3B Gene

No ASD Table

Relevant External Links for KIF3B Gene

GeneLoc Exon Structure for
KIF3B
ECgene alternative splicing isoforms for
KIF3B

Expression for KIF3B Gene

mRNA expression in normal human tissues for KIF3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KIF3B Gene

This gene is overexpressed in Brain (29.3) and Fetal Brain (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIF3B Gene



SOURCE GeneReport for Unigene cluster for KIF3B Gene Hs.369670

genes like me logo Genes that share expression patterns with KIF3B: view

Protein tissue co-expression partners for KIF3B Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KIF3B Gene

Orthologs for KIF3B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KIF3B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KIF3B 35
  • 91.21 (n)
  • 97.98 (a)
KIF3B 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIF3B 35
  • 94.29 (n)
  • 99.46 (a)
KIF3B 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kif3b 35
  • 90.14 (n)
  • 97.99 (a)
Kif3b 16
Kif3b 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KIF3B 35
  • 99.82 (n)
  • 100 (a)
KIF3B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kif3b 35
  • 90.54 (n)
  • 97.86 (a)
oppossum
(Monodelphis domestica)
Mammalia KIF3B 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIF3B 35
  • 80.29 (n)
  • 92.96 (a)
KIF3B 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIF3B 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kif3b 35
  • 75.27 (n)
  • 86.96 (a)
Str.16554 35
zebrafish
(Danio rerio)
Actinopterygii kif3b 35
  • 72.77 (n)
  • 81.83 (a)
kif3b 36
  • 79 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Kif19A 37
  • 29 (a)
Kif3C 37
  • 37 (a)
Klp64D 37
  • 75 (a)
Klp68D 37
  • 47 (a)
nod 37
  • 35 (a)
Klp68D 35
  • 56.67 (n)
  • 51.67 (a)
Klp68D 36
  • 43 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010396 35
  • 57.04 (n)
  • 52.59 (a)
worm
(Caenorhabditis elegans)
Secernentea klp-11 37
  • 56 (a)
osm-3 37
  • 39 (a)
klp-11 35
  • 58.35 (n)
  • 59.66 (a)
klp-11 36
  • 33 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIP2 38
corn
(Zea mays)
Liliopsida Zm.13329 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 65 (a)
OneToMany
Species with no ortholog for KIF3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIF3B Gene

ENSEMBL:
Gene Tree for KIF3B (if available)
TreeFam:
Gene Tree for KIF3B (if available)

Paralogs for KIF3B Gene

(12) SIMAP similar genes for KIF3B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KIF3B: view

Variants for KIF3B Gene

Sequence variations from dbSNP and Humsavar for KIF3B Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs13111 -- 32,334,596(+) TGGAC(A/G)AAAAT utr-variant-3-prime
rs14353 -- 32,334,595(-) TTTTC(A/G)TCCAC utr-variant-3-prime
rs975651 -- 32,303,951(+) GACCC(C/T)CTGAC intron-variant
rs1022685 -- 32,330,959(+) TCAGG(A/G)AAGGA intron-variant
rs1028563 -- 32,330,729(+) catct(C/T)taagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF3B Gene

Variant ID Type Subtype PubMed ID
nsv833954 CNV Loss 17160897
nsv509764 CNV Insertion 20534489
nsv179526 CNV Loss 16902084
esv2670812 CNV Deletion 23128226
esv2493207 CNV Deletion 19546169
esv2404832 CNV Deletion 18987734
esv2722342 CNV Deletion 23290073
esv3059 CNV Deletion 18987735
dgv22e197 CNV Deletion 19546169
esv1431260 CNV Deletion 17803354
nsv178620 CNV Loss 16902084
esv1171233 CNV Insertion 17803354
esv1131334 CNV Insertion 17803354
esv1121934 CNV Insertion 17803354
esv1361811 CNV Insertion 17803354
esv1301631 CNV Insertion 17803354

Variation tolerance for KIF3B Gene

Residual Variation Intolerance Score: 4.81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.15; 23.32% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KIF3B Gene

Disorders for KIF3B Gene

MalaCards: The human disease database

(3) MalaCards diseases for KIF3B Gene - From: DISEASES

Disorder Aliases PubMed IDs
tuberculous peritonitis
  • peritonitis tuberculous
corneal dystrophy, posterior polymorphous, 1
  • posterior polymorphous corneal dystrophy
asphyxiating thoracic dystrophy
  • ataxia telangiectasia
- elite association - COSMIC cancer census association via MalaCards
Search KIF3B in MalaCards View complete list of genes associated with diseases

Relevant External Links for KIF3B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIF3B
genes like me logo Genes that share disorders with KIF3B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIF3B Gene

Publications for KIF3B Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 2 3 4 67
  2. Regulation of mitotic spindle formation by the RhoA guanine nucleotide exchange factor ARHGEF10. (PMID: 19635168) Aoki T. … Satoh T. (BMC Cell Biol. 2009) 3 23
  3. Photoreceptor localization of the KIF3A and KIF3B subunits of the heterotrimeric microtubule motor kinesin II in vertebrate retina. (PMID: 10548469) Whitehead J.L. … Burnside B. (Exp. Eye Res. 1999) 3 23
  4. Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide. (PMID: 9506951) Shimizu K. … Takai Y. (J. Biol. Chem. 1998) 3 23
  5. The heterotrimeric kinesin-2 complex interacts with and regulates GLI protein function. (PMID: 25588831) Carpenter B.S. … Allen B.L. (J. Cell. Sci. 2015) 3

Products for KIF3B Gene

Sources for KIF3B Gene

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