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Aliases for KIF3B Gene

Aliases for KIF3B Gene

  • Kinesin Family Member 3B 2 3
  • Microtubule Plus End-Directed Kinesin Motor 3B 3 4
  • KIAA0359 4 6
  • HH0048 3 4
  • Kinesin-Like Protein KIF3B 3
  • KLP-11 3
  • FLA8 3

External Ids for KIF3B Gene

Previous GeneCards Identifiers for KIF3B Gene

  • GC20P030653
  • GC20P031564
  • GC20P031610
  • GC20P030329
  • GC20P030865
  • GC20P027653

Summaries for KIF3B Gene

Entrez Gene Summary for KIF3B Gene

  • The protein encoded by this gene acts as a heterodimer with kinesin family member 3A to aid in chromosome movement during mitosis and meiosis. The encoded protein is a plus end-directed microtubule motor and can interact with the SMC3 subunit of the cohesin complex. In addition, the encoded protein may be involved in the intracellular movement of membranous organelles. This protein and kinesin family member 3A form the kinesin II subfamily of the kinesin superfamily. [provided by RefSeq, Jul 2008]

GeneCards Summary for KIF3B Gene

KIF3B (Kinesin Family Member 3B) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Hemostasis. GO annotations related to this gene include microtubule binding and Rho GTPase binding. An important paralog of this gene is KIF5C.

UniProtKB/Swiss-Prot for KIF3B Gene

  • Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity).

Gene Wiki entry for KIF3B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF3B Gene

Genomics for KIF3B Gene

Regulatory Elements for KIF3B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KIF3B Gene

Start:
32,277,651 bp from pter
End:
32,335,011 bp from pter
Size:
57,361 bases
Orientation:
Plus strand

Genomic View for KIF3B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIF3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF3B Gene

Proteins for KIF3B Gene

  • Protein details for KIF3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15066-KIF3B_HUMAN
    Recommended name:
    Kinesin-like protein KIF3B
    Protein Accession:
    O15066
    Secondary Accessions:
    • B2RMP4
    • B4DSR5
    • E1P5M5

    Protein attributes for KIF3B Gene

    Size:
    747 amino acids
    Molecular mass:
    85125 Da
    Quaternary structure:
    • Heterodimer of KIF3A and KIF3B. Interacts directly with IFT20 (By similarity). Interacts with the SMC3 subunit of the cohesin complex.
    SequenceCaution:
    • Sequence=BAA20815.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KIF3B Gene

    Alternative splice isoforms for KIF3B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF3B Gene

Proteomics data for KIF3B Gene at MOPED

Post-translational modifications for KIF3B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIF3B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KIF3B Gene

Domains for KIF3B Gene

Gene Families for KIF3B Gene

HGNC:
  • KIF :Kinesins

Protein Domains for KIF3B Gene

Suggested Antigen Peptide Sequences for KIF3B Gene

Graphical View of Domain Structure for InterPro Entry

O15066

UniProtKB/Swiss-Prot:

KIF3B_HUMAN :
  • O15066
Domain:
  • Contains 1 kinesin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.
genes like me logo Genes that share domains with KIF3B: view

Function for KIF3B Gene

Molecular function for KIF3B Gene

GENATLAS Biochemistry: kinesin family 3 member B,cDNA sequence,expressed in brain,>100kDa,homolog to murine kinesin KIF3B
UniProtKB/Swiss-Prot Function: Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity).

Gene Ontology (GO) - Molecular Function for KIF3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity IBA --
GO:0005515 protein binding IPI 16298999
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed TAS 7559760
genes like me logo Genes that share ontologies with KIF3B: view
genes like me logo Genes that share phenotypes with KIF3B: view

Animal Models for KIF3B Gene

MGI Knock Outs for KIF3B:

Animal Model Products

CRISPR Products

miRNA for KIF3B Gene

miRTarBase miRNAs that target KIF3B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIF3B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for KIF3B Gene

Localization for KIF3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF3B Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIF3B Gene COMPARTMENTS Subcellular localization image for KIF3B gene
Compartment Confidence
cytoskeleton 4
cytosol 4
nucleus 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for KIF3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome NAS 16298999
GO:0005819 spindle --
GO:0005829 cytosol TAS --
GO:0005873 plus-end kinesin complex TAS 7559760
GO:0005876 colocalizes_with spindle microtubule NAS 16298999
genes like me logo Genes that share ontologies with KIF3B: view

Pathways for KIF3B Gene

genes like me logo Genes that share pathways with KIF3B: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for KIF3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006996 organelle organization TAS --
GO:0007018 microtubule-based movement TAS --
GO:0007052 mitotic spindle organization TAS 16298999
GO:0007100 mitotic centrosome separation TAS 16298999
genes like me logo Genes that share ontologies with KIF3B: view

Compounds for KIF3B Gene

(1) Drugbank Compounds for KIF3B Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Adenosine-5'-Diphosphate
20398-34-9 target
genes like me logo Genes that share compounds with KIF3B: view

Transcripts for KIF3B Gene

mRNA/cDNA for KIF3B Gene

Unigene Clusters for KIF3B Gene

Kinesin family member 3B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIF3B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KIF3B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF3B Gene

No ASD Table

Relevant External Links for KIF3B Gene

GeneLoc Exon Structure for
KIF3B
ECgene alternative splicing isoforms for
KIF3B

Expression for KIF3B Gene

mRNA expression in normal human tissues for KIF3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIF3B Gene

SOURCE GeneReport for Unigene cluster for KIF3B Gene Hs.369670

genes like me logo Genes that share expressions with KIF3B: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KIF3B Gene

Orthologs for KIF3B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KIF3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF3B 35
  • 99.82 (n)
  • 100 (a)
KIF3B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIF3B 35
  • 91.21 (n)
  • 97.98 (a)
KIF3B 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIF3B 35
  • 94.29 (n)
  • 99.46 (a)
KIF3B 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kif3b 35
  • 90.14 (n)
  • 97.99 (a)
Kif3b 16
Kif3b 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIF3B 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kif3b 35
  • 90.54 (n)
  • 97.86 (a)
chicken
(Gallus gallus)
Aves KIF3B 35
  • 80.29 (n)
  • 92.96 (a)
KIF3B 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIF3B 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kif3b 35
  • 75.27 (n)
  • 86.96 (a)
Str.16554 35
zebrafish
(Danio rerio)
Actinopterygii kif3b 35
  • 72.77 (n)
  • 81.83 (a)
kif3b 36
  • 79 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010396 35
  • 57.04 (n)
  • 52.59 (a)
fruit fly
(Drosophila melanogaster)
Insecta Klp68D 35
  • 56.67 (n)
  • 51.67 (a)
Klp68D 36
  • 43 (a)
OneToMany
Klp68D 37
  • 47 (a)
nod 37
  • 35 (a)
Kif19A 37
  • 29 (a)
Klp64D 37
  • 75 (a)
Kif3C 37
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea klp-11 35
  • 58.35 (n)
  • 59.66 (a)
klp-11 36
  • 33 (a)
OneToMany
klp-11 37
  • 56 (a)
osm-3 37
  • 39 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIP2 38
corn
(Zea mays)
Liliopsida Zm.13329 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 65 (a)
OneToMany
Species with no ortholog for KIF3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIF3B Gene

ENSEMBL:
Gene Tree for KIF3B (if available)
TreeFam:
Gene Tree for KIF3B (if available)

Paralogs for KIF3B Gene

Selected SIMAP similar genes for KIF3B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KIF3B: view

Variants for KIF3B Gene

Sequence variations from dbSNP and Humsavar for KIF3B Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs13111 -- 32,334,596(+) TGGAC(A/G)AAAAT utr-variant-3-prime
rs14353 -- 32,334,595(-) TTTTC(A/G)TCCAC utr-variant-3-prime
rs933004 -- 32,329,704(+) AAAAT(A/G)TATTG intron-variant
rs975651 -- 32,303,951(+) GACCC(C/T)CTGAC intron-variant
rs1022685 -- 32,330,959(+) TCAGG(A/G)AAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF3B Gene

Variant ID Type Subtype PubMed ID
nsv833954 CNV Loss 17160897
nsv509764 CNV Insertion 20534489
nsv179526 CNV Loss 16902084
esv2670812 CNV Deletion 23128226
esv2493207 CNV Deletion 19546169
esv2404832 CNV Deletion 18987734
esv2722342 CNV Deletion 23290073
esv3059 CNV Deletion 18987735
dgv22e197 CNV Deletion 19546169
esv1431260 CNV Deletion 17803354
nsv178620 CNV Loss 16902084
esv1171233 CNV Insertion 17803354
esv1131334 CNV Insertion 17803354
esv1121934 CNV Insertion 17803354
esv1361811 CNV Insertion 17803354
esv1301631 CNV Insertion 17803354

Relevant External Links for KIF3B Gene

HapMap Linkage Disequilibrium report
KIF3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF3B Gene

Disorders for KIF3B Gene

No disorders were found for KIF3B Gene.

No data available for UniProtKB/Swiss-Prot for KIF3B Gene

Publications for KIF3B Gene

  1. Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide. (PMID: 9506951) Shimizu K. … Takai Y. (J. Biol. Chem. 1998) 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 2 3 4
  3. Photoreceptor localization of the KIF3A and KIF3B subunits of the heterotrimeric microtubule motor kinesin II in vertebrate retina. (PMID: 10548469) Whitehead J.L. … Burnside B. (Exp. Eye Res. 1999) 3 23
  4. Regulation of mitotic spindle formation by the RhoA guanine nucleotide exchange factor ARHGEF10. (PMID: 19635168) Aoki T. … Satoh T. (BMC Cell Biol. 2009) 3 23
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4

Products for KIF3B Gene

Sources for KIF3B Gene

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