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KIF3A Gene

protein-coding   GIFtS: 61
GCID: GC05M132059

Kinesin Family Member 3A

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kinesin Family Member 3A1 2     KLP-202
Kinesin Family Protein 3A1 2     Kinesin-Like Protein KIF3A2
Microtubule Plus End-Directed Kinesin Motor 3A2 3     KIF33
FLA102     

External Ids:    HGNC: 63191   Entrez Gene: 111272   Ensembl: ENSG000001314377   OMIM: 6046835   UniProtKB: Q9Y4963   

Export aliases for KIF3A gene to outside databases

Previous GC identifers: GC05M131554 GC05M132479 GC05M132064 GC05M132107 GC05M127220


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KIF3A Gene:
KIF3A (kinesin family member 3A) is a protein-coding gene. Diseases associated with KIF3A include gardner syndrome, and orofaciodigital syndrome. GO annotations related to this gene include microtubule binding and plus-end-directed microtubule motor activity. An important paralog of this gene is KIF4A.

UniProtKB/Swiss-Prot: KIF3A_HUMAN, Q9Y496
Function: Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule
sliding activity in vitro. Plays a role in primary cilia formation (By similarity)

Gene Wiki entry for KIF3A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KIF3A gene promoter:
         AhR   TBP   SRF   Sox5   SRF (504 AA)   MEF-2A   HEN1   AREB6   COMP1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKIF3A promoter sequence
   Search Chromatin IP Primers for KIF3A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KIF3A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q31

KIF3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIF3A gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M132059:  view genomic region     (about GC identifiers)

Start:
132,028,320 bp from pter      End:
132,073,330 bp from pter
Size:
45,011 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KIF3A_HUMAN, Q9Y496 (See protein sequence)
Recommended Name: Kinesin-like protein KIF3A  
Size: 699 amino acids; 80041 Da
Subunit: Heterodimer of KIF3A and KIF3B. Interacts with PIFO. Interacts with CLN3
Sequence caution: Sequence=AAC04475.1; Type=Erroneous gene model prediction; Sequence=BAD93017.1; Type=Erroneous
initiation; Note=Translation N-terminally shortened;
Secondary accessions: A8MSW9 Q59EN1 Q86XE9 Q9Y6V4

Explore the universe of human proteins at neXtProt for KIF3A: NX_Q9Y496

Explore proteomics data for KIF3A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KIF3A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_008985.3  
    ENSEMBL proteins: 
     ENSP00000368020   ENSP00000368009   ENSP00000405619   ENSP00000385808   ENSP00000391863  
    Reactome Protein details: Q9Y496

    KIF3A Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for KIF3A

    KIF3A Antibody Products:

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    Cloud-Clone Corp. CLIAs for KIF3A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KIF: Kinesins

    4 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR001752 Kinesin_motor_dom
     IPR019821 Kinesin_motor_CS
     IPR027640 Kinesin-like_fam

    Graphical View of Domain Structure for InterPro Entry Q9Y496

    ProtoNet protein and cluster: Q9Y496

    1 Blocks protein domain: IPB001752 Kinesin

    UniProtKB/Swiss-Prot: KIF3A_HUMAN, Q9Y496
    Similarity: Belongs to the kinesin-like protein family. Kinesin II subfamily
    Similarity: Contains 1 kinesin-motor domain


    KIF3A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KIF3A_HUMAN, Q9Y496
    Function: Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule
    sliding activity in vitro. Plays a role in primary cilia formation (By similarity)

         Genatlas biochemistry entry for KIF3A:
    kinesin heavy chain member 3-like,mouse Kif3 homolog,putative microtubule associated motor protein,ATP dependent
    superfamily,N type,involved in anterograde transport of membranous organelles,distinct from synaptic vesicles

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003777microtubule motor activity ----
    GO:0005515protein binding IPI16298999
    GO:0005524ATP binding IEA--
    GO:0008017microtubule binding IEA--
    GO:0008574plus-end-directed microtubule motor activity TAS16298999
         
    KIF3A for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for KIF3A:
     G0/1 arrest  Increased G1 DNA content  Upregulation of Wnt/beta-caten 

         15 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Kif3a):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  growth/size/body  homeostasis/metabolism  limbs/digits/tail  mortality/aging 
     nervous system  renal/urinary system  respiratory system  skeleton  vision/eye 

    KIF3A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for KIF3A: Kif3atm1Noh Kif3atm1Gsn

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KIF3A
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KIF3A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KIF3A

    miRNA
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    Block miRNA regulation of human, mouse, rat KIF3A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KIF3A (see all 49):
    hsa-miR-323-3p hsa-miR-579 hsa-miR-4307 hsa-miR-607 hsa-miR-513a-5p hsa-miR-139-5p hsa-miR-200a hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidKIF3A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for KIF3A
    Predesigned siRNA for gene silencing in human, mouse, rat KIF3A

    Gene Editing
    Products:
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    Clone
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    GenScript: all cDNA clones in your preferred vector: KIF3A (NM_007054)
    Sino Biological Human cDNA Clone for KIF3A
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF3A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KIF3A_HUMAN, Q9Y496: Cytoplasm, cytoskeleton (Probable). Cell projection, cilium (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol4
    nucleus2
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005813centrosome IDA16298999
    GO:0005829cytosol TAS--
    GO:0005871kinesin complex ----
    GO:0005874microtubule ----
    GO:0005876spindle microtubule IDA16298999

    KIF3A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KIF3A About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Clathrin derived vesicle budding
    Membrane Trafficking0.32
    Translocation of GLUT4 to the Plasma Membrane0.32
    2Hemostasis
    Hemostasis0.43
    3Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    4Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch
    5MHC class II antigen presentation
    MHC class II antigen presentation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for KIF3A
        Wnt / Hedgehog / Notch
    Cytoskeletal Signaling

    3 BioSystems Pathways for KIF3A
        Insulin Signaling
    Endochondral Ossification
    Hedgehog signaling events mediated by Gli proteins


    3 Reactome Pathways for KIF3A
        Translocation of GLUT4 to the plasma membrane
    MHC class II antigen presentation
    Kinesins



    KIF3A for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including KIF3A: 
              Primary Cilia in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for KIF3A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KIF3A (Q9Y4961, 3 ENSP000003680204) via UniProtKB, MINT, STRING, and/or I2D (see all 130)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DISC1Q9NRI51, 3, ENSP000003555964EBI-1104844,EBI-529989 I2D: score=2 STRING: ENSP00000355596
    GRB2P629933, ENSP000003390074I2D: score=2 STRING: ENSP00000339007
    KIF3CO147823, ENSP000002647124I2D: score=2 STRING: ENSP00000264712
    PPP1R15AO758073, ENSP000002004534I2D: score=2 STRING: ENSP00000200453
    USP7Q930093, ENSP000003435354I2D: score=2 STRING: ENSP00000343535
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0001822kidney development IEA--
    GO:0006996organelle organization TAS1447303
    GO:0007018microtubule-based movement TAS--
    GO:0007224smoothened signaling pathway IEA--

    KIF3A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KIF3A



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KIF3A gene: 
    NM_007054.5  

    Unigene Cluster for KIF3A:

    Kinesin family member 3A
    Hs.43670  [show with all ESTs]
    Unigene Representative Sequence: NM_007054
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378746(uc003kxm.3 uc003kxn.3 uc003kxo.3 uc011cxf.2 uc003kxp.3)
    ENST00000378735 ENST00000450441 ENST00000488471 ENST00000403231 ENST00000487055
    ENST00000428744
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate KIF3A (see all 49):
    hsa-miR-323-3p hsa-miR-579 hsa-miR-4307 hsa-miR-607 hsa-miR-513a-5p hsa-miR-139-5p hsa-miR-200a hsa-miR-30d
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    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat KIF3A
      QuantiFast Probe-based Assays in human, mouse, rat KIF3A

    Additional mRNA sequence: 

    AB209780.1 AF041853.1 AK295089.1 AK313359.1 AM177178.1 BC020890.1 BC032599.1 BC039592.1 
    BC045542.1 

    6 DOTS entries:

    DT.101958929  DT.211030  DT.100751118  DT.91842477  DT.92476587  DT.91671156 

    Selected AceView cDNA sequences (see all 152):

    AI433768 N35857 BP356521 BC039592 BM785690 CR621012 BI789080 AL705264 
    BM931991 BU686973 R69257 AI887633 BU674410 AI371039 BM873600 AA351156 
    BM978559 W70205 BX324375 NM_007054 AW172267 BC020890 AA642359 AI285015 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KIF3A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTAAATAAG
    KIF3A Expression
    About this image

    KIF3A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KIF3A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.43670
        Pathway & Disease-focused RT2 Profiler PCR Array including KIF3A: 
              Primary Cilia in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF3A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KIF3A gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kif3a1 , 5 kinesin family member 3A1, 5 86.98(n)1
    96.57(a)1
      11 (31.97 cM)5
    165681  NM_008443.31  NP_032469.21 
     535673795 
    chicken
    (Gallus gallus)
    Aves KIF3A1 kinesin family member 3A 81.69(n)
    94.85(a)
      416332  NM_001030622.1  NP_001025793.1 
    lizard
    (Anolis carolinensis)
    Reptilia KIF3A6
    kinesin family member 3A
    92(a)
    1 ↔ 1
    2(127572427-127610906)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.6252 Xenopus laevis mRNA for Kinesin-like protein (xklp3A gene) less 79.7(n)    AJ311602.1 
    zebrafish
    (Danio rerio)
    Actinopterygii kif3a1 kinesin family member 3A 77.14(n)
    92.68(a)
      550267  NM_001017604.2  NP_001017604.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Klp64D1 , 3 microtubule-based movement kinesin
    motor3
    Kinesin-like protein at 64D1
    80(a)
    (best of 4)3
    59.13(n)1
    61.08(a)1
      64D13
    386111  NM_079210.21  NP_523934.11 
    worm
    (Caenorhabditis elegans)
    Secernentea klp-113
    klp-201
    Expression: sensory neurons, dorsal
    nerve cord, ventral nerve cord, motor
    neurons, amphid neurons, inner labial
    neurons, phasmid neurons less3
    klp-201
    47(a)
    (best of 2)3
    57.71(n)1
    58.29(a)1
      IV(8756921-8762182)3
    35650571  NM_064777.41  NP_497178.11 


    ENSEMBL Gene Tree for KIF3A (if available)
    TreeFam Gene Tree for KIF3A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KIF3A gene
    KIF4A2  KIF5B2  KIF5C2  KIF21A2  KIF112  KIF3B2  KIF21B2  KIF172  
    CENPE2  KIF152  KIF5A2  KIF72  KIF4B2  KIF272  KIF3C2  
    Selected SIMAP similar genes for KIF3A using alignment to 9 protein entries:     KIF3A_HUMAN (see all proteins) (see all similar genes):
    KIF3B    KIF3C    DKFZp686G1646    KIF17    KIFC3    KIF15
    KIF13A    KIF13B    KIF5C    KIF1A    KIF1B    KIF1Bbeta
    KIF7    KIF5A    CENPE    KIF16B    KIF5B    KIF22

    KIF3A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for KIF3A
    PGOHUM00000238313


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KIF3A (see all 878)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1924278341,2
    --132027903(+) GGAGCC/TAAATG 1 -- ds50010--------
    rs1839205371,2
    --132027926(+) GAACAC/TGAAGA 1 -- ds50010--------
    rs556964331,2
    C,F--132027927(+) AACACG/AAAGAA 1 -- ds50013Minor allele frequency- A:0.07WA 122
    rs1884097241,2
    --132027984(+) AGGGAA/GAAGAG 1 -- ds50010--------
    rs1146425901,2
    C,F--132027989(+) GAAGAG/ACAGAA 1 -- ds50011Minor allele frequency- A:0.02NA 120
    rs1812137361,2
    --132028099(+) TGTACC/TGCCAA 1 -- ds50010--------
    rs1386415791,2
    --132028153(+) CTTCAC/TGATTT 1 -- ds50010--------
    rs1493259771,2
    --132028185(+) TTAAGC/TGTTTC 1 -- ds50010--------
    rs1435783461,2
    C--132028283(+) ACCACA/GAAGAT 1 -- ds50010--------
    rs115457221,2
    C--132028540(+) TATAAG/ATTCAA 1 -- ut311Minor allele frequency- A:0.00NA 2

    HapMap Linkage Disequilibrium report for KIF3A (132028320 - 132073330 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for KIF3A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv529021CNV Loss19592680
    nsv521072CNV Loss19592680
    dgv6335n71CNV Loss21882294
    nsv882918CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KIF3A
    DNA2.0 Custom Variant and Variant Library Synthesis for KIF3A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604683    OMIM disorders: --

    Selected diseases for KIF3A (see all 23):    
    About MalaCards
    gardner syndrome    orofaciodigital syndrome    familial juvenile hyperuricemic nephropathy    neuronal ceroid lipofuscinosis
    cystic kidney    situs inversus    was-related disorders    familial adenomatous polyposis
    atopic dermatitis    kidney disease    polycystic kidney disease    retinitis pigmentosa
    kaposi's sarcoma    dermatitis    retinitis    asthma
    sarcoma    tuberculosis    schizophrenia    cystic fibrosis

    3 diseases from the University of Copenhagen DISEASES database for KIF3A:
    Polycystic kidney disease     Orofaciodigital syndrome     Cystic kidney

    KIF3A for disorders           About GeneDecksing

    Genetic Association Database (GAD): KIF3A
    Human Genome Epidemiology (HuGE) Navigator: KIF3A (4 documents)

    Export disorders for KIF3A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KIF3A gene, integrated from 10 sources (see all 68):
    (articles sorted by number of sources associating them with KIF3A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. (PubMed id 22197932)1, 4 Paternoster L....Weidinger S. (Nat. Genet. 2012)
    2. Association analysis of susceptibility candidate region on chromosome 5q31 for tuberculosis. (PubMed id 20485362)1, 4 Ridruechai C....Tokunaga K. (Genes Immun. 2010)
    3. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)1, 2 Schmutz J.... Rubin E.M. (Nature 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Photoreceptor localization of the KIF3A and KIF3B subunits of the heterotrimeric microtubule motor kinesin II in vertebrate retina. (PubMed id 10548469)1, 2 Whitehead J.L....Burnside B. (Exp. Eye Res. 1999)
    6. A theory of evolution above the species level. (PubMed id 1054846)1, 3 Stanley S.M. (Proc. Natl. Acad. Sci. U.S.A. 1975)
    7. Visualization of translated tau protein in the axons of neuronal P19 cells and characterization of tau RNP granules. (PubMed id 12235292)1, 9 Aronov S....Ginzburg I. (J. Cell. Sci. 2002)
    8. Role of the kinesin-2 family protein, KIF3, during mitosis. (PubMed id 16298999)1, 9 Haraguchi K....Akiyama T. (J. Biol. Chem. 2006)
    9. Association of KIF3A, but not OVOL1 and ACTL9, with atopic eczema in Italian patients. (PubMed id 23278845)1 Lepre T....Giardina E. (Br. J. Dermatol. 2013)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11127 HGNC: 6319 AceView: KIF3A Ensembl:ENSG00000131437 euGenes: HUgn11127
    ECgene: KIF3A H-InvDB: KIF3A

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KIF3A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for KIF3A gene:
    Search GeneIP for patents involving KIF3A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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