Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KIF3A Gene

protein-coding   GIFtS: 57
GCID: GC05M132059

kinesin family member 3A

 Explore 23 diseases affiliated with
KIF3A via our new
 Human Malady Compendium 
Biological research products
for KIF3A
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Kinesin Family Member 3A1 2     Kinesin Family Protein 3A2
FLA101 2     Kinesin-Like Protein KIF3A2
KLP-201 2     KIF33
Microtubule Plus End-Directed Kinesin Motor 3A2 3     

External Ids:    HGNC: 63191   Entrez Gene: 111272   Ensembl: ENSG000001314377   OMIM: 6046835   UniProtKB: Q9Y4963   

Export aliases for KIF3A gene to outside databases

Previous GC identifers: GC05M131554 GC05M132479 GC05M132064 GC05M132107 GC05M127220


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: KIF3A_HUMAN, Q9Y496
Function: Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding
activity in vitro. Plays a role in primary cilia formation (By similarity)

Gene Wiki entry for KIF3A


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_034772.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KIF3A gene promoter:
         AhR   TBP   SRF   Sox5   SRF (504 AA)   MEF-2A   HEN1   AREB6   COMP1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKIF3A promoter sequence
   Search SABiosciences Chromatin IP Primers for KIF3A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIF3A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q31

KIF3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIF3A gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M132059:  view genomic region     (about GC identifiers)

Start:
132,028,323 bp from pter      End:
132,073,330 bp from pter
Size:
45,008 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KIF3A_HUMAN, Q9Y496 (See protein sequence)
Recommended Name: Kinesin-like protein KIF3A  
Size: 699 amino acids; 80041 Da
Subunit: Heterodimer of KIF3A and KIF3B. Interacts with PIFO. Interacts with CLN3
Subcellular location: Cytoplasm, cytoskeleton (Probable). Cell projection, cilium (By similarity)
Sequence caution: Sequence=AAC04475.1; Type=Erroneous gene model prediction; Sequence=BAD93017.1; Type=Erroneous
initiation; Note=Translation N-terminally shortened;
Secondary accessions: A8MSW9 Q59EN1 Q86XE9 Q9Y6V4

Explore the universe of human proteins at neXtProt for KIF3A: NX_Q9Y496

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y496

  • KIF3A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_008985.3  
    ENSEMBL proteins: 
     ENSP00000368020   ENSP00000368009   ENSP00000405619   ENSP00000385808   ENSP00000391863  
    Reactome Protein details: Q9Y496
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for KIF3A 
    GenScript Custom Purified and Recombinant Proteins Services for KIF3A
    Novus Biologicals KIF3A Protein
    Novus Biologicals KIF3A Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for KIF3A

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005813centrosome IDA16298999
    GO:0005829cytosol TAS--
    GO:0005874microtubule ----
    GO:0005876spindle microtubule IDA16298999
    GO:0016939kinesin II complex IDA16298999


    KIF3A for ontologies           About GeneDecksing



    KIF3A Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of KIF3A
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for KIF3A 
    OriGene Antibodies: KIF3A
    OriGene Custom Antibody Services for KIF3A 
    GenScript Custom Superior Antibodies Services for KIF3A
    Novus Biologicals KIF3A Antibodies
    Abcam antibodies for KIF3A 
    Uscn Antibodies for KIF3A
    Search ThermoFisher Antibodies for KIF3A

    Assay Products for KIF3A: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KIF3A
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for KIF3A


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    KIF3A for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001752 Kinesin_motor_dom
     IPR019821 Kinesin_motor_CS

    Graphical View of Domain Structure for InterPro Entry Q9Y496

    ProtoNet protein and cluster: Q9Y496

    1 Blocks protein family: IPB001752 Kinesin

    UniProtKB/Swiss-Prot: KIF3A_HUMAN, Q9Y496
    Similarity: Belongs to the kinesin-like protein family. Kinesin II subfamily
    Similarity: Contains 1 kinesin-motor domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: KIF3A_HUMAN, Q9Y496
    Function: Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding
    activity in vitro. Plays a role in primary cilia formation (By similarity)

         Genatlas biochemistry entry for KIF3A:
    kinesin heavy chain member 3-like,mouse Kif3 homolog,putative microtubule associated motor protein,ATP dependent
    superfamily,N type,involved in anterograde transport of membranous organelles,distinct from synaptic vesicles

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: KIF3A
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KIF3A
    8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate KIF3A (see all 49):
    hsa-miR-323-3p hsa-miR-579 hsa-miR-4307 hsa-miR-607 hsa-miR-513a-5p hsa-miR-139-5p hsa-miR-200a hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidKIF3A 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KIF3A (see all 4)
    OriGene shRNA RFP: KIF3A
    OriGene siRNA: KIF3A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIF3A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KIF3A

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIF3A (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIF3A
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: KIF3A (NM_007054)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KIF3A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIF3A 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KIF3A
    Search LifeMap BioReagents cell lines for KIF3A

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF3A

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003777microtubule motor activity ----
    GO:0005515protein binding IPI16298999
    GO:0005524ATP binding IEA--
    GO:0008574plus-end-directed microtubule motor activity TAS16298999


    KIF3A for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for KIF3A:
     G0/1 arrest  Increased G1 DNA content  Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-outs for KIF3A: Kif3atm1Noh Kif3atm1Gsn
         15 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Kif3a):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  growth/size  homeostasis/metabolism  limbs/digits/tail  mortality/aging 
     nervous system  renal/urinary system  respiratory system  skeleton  vision/eye 

    KIF3A for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/11 super-pathways (see all 11About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Immune System
    Immune System1.00
    Adaptive Immune System0.59
    2Kinesins
    Kinesins1.00
    Kinesins move along microtubules consuming ATP0.95
    3MHC class II antigen presentation
    MHC class II antigen presentation1.00
    Transport of antigen loaded MHC II molecules to surface0.59
    4Membrane Trafficking
    Membrane Trafficking1.00
    Translocation of GLUT4 to the Plasma Membrane0.32
    5Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for KIF3A
        Wnt / Hedgehog / Notch
    Cytoskeletal Signaling

    3 BioSystems Pathways for KIF3A 
        Insulin Signaling
    Endochondral Ossification
    Hedgehog signaling events mediated by Gli proteins

    5/10        Reactome Pathways for KIF3A (see all 10)
        Hemostasis
    Membrane Trafficking
    Translocation of GLUT4 to the Plasma Membrane
    Adaptive Immune System
    Transport of antigen loaded MHC II molecules to surface



    KIF3A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KIF3A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/81 Interacting proteins for KIF3A (Q9Y4961, 3 ENSP000003680204) via UniProtKB, MINT, STRING, and/or I2D (see all 81)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DISC1Q9NRI51, 3, ENSP000003555964EBI-1104844,EBI-529989 I2D: score=2 STRING: ENSP00000355596
    MAP3K11Q165843, ENSP000003095974I2D: score=3 STRING: ENSP00000309597
    KIF3CO147823, ENSP000002647124I2D: score=2 STRING: ENSP00000264712
    PLEKHA5Q9HAU03, ENSP000002992754I2D: score=2 STRING: ENSP00000299275
    USP7Q930093, ENSP000003435354I2D: score=2 STRING: ENSP00000343535
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0001822kidney development IEA--
    GO:0006996organelle organization TAS1447303
    GO:0007018microtubule-based movement TAS--
    GO:0007224smoothened signaling pathway IEA--


    KIF3A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KIF3A
    Search CenterWatch for drugs/clinical trials and news about KIF3A 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KIF3A gene: 
    NM_007054.5  

    Unigene Cluster for KIF3A:

    Kinesin family member 3A
    Hs.43670  [show with all ESTs]
    Unigene Representative Sequence: NM_007054
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378746(uc003kxm.3 uc003kxn.3 uc003kxo.3 uc011cxf.2 uc003kxp.3)
    ENST00000378735 ENST00000450441 ENST00000488471 ENST00000403231 ENST00000487055
    ENST00000428744

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: KIF3A
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KIF3A
    8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate KIF3A (see all 49):
    hsa-miR-323-3p hsa-miR-579 hsa-miR-4307 hsa-miR-607 hsa-miR-513a-5p hsa-miR-139-5p hsa-miR-200a hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidKIF3A 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KIF3A (see all 4)
    OriGene shRNA RFP: KIF3A
    OriGene siRNA: KIF3A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIF3A
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIF3A (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIF3A
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: KIF3A (NM_007054)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KIF3A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIF3A 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIF3A
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KIF3A
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIF3A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIF3A

    Additional cDNA sequence: 

    AB209780.1 AF041853.1 AK295089.1 AK313359.1 AM177178.1 BC020890.1 BC032599.1 BC039592.1 
    BC045542.1 

    6 DOTS entries:

    DT.101958929  DT.211030  DT.100751118  DT.91842477  DT.92476587  DT.91671156 

    24/152 AceView cDNA sequences (see all 152):

    BM931991 BP356521 BU686973 AI285015 AA642359 AW172267 AI887633 BC020890 
    BU674410 AI371039 BX951661 BM874555 BX324375 W70205 N35857 AA351156 
    CR621012 BM873600 NM_007054 AL705264 BI962521 BC039592 BM785690 AI433768 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KIF3A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTTAAATAAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See KIF3A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KIF3A

    SOURCE GeneReport for Unigene cluster: Hs.43670
        SABiosciences Expression via Pathway-Focused PCR Array including KIF3A: 
              Primary Cilia in human mouse rat

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIF3A
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KIF3A
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIF3A
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIF3A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF3A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for KIF3A gene from 7/27 species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves KIF3A1 kinesin family member 3A 82.26(n)
    95.99(a)
      416332  NM_001030622.1  NP_001025793.1 
    lizard
    (Anolis carolinensis)
    Reptilia KIF3A6
    --
    92(a)
    1 ↔ 1
    2(127581713-127606638)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.6252 Xenopus laevis mRNA for Kinesin-like protein (xklp3A more 79.7(n)    AJ311602.1 
    zebrafish
    (Danio rerio)
    Actinopterygii kif3a1 kinesin family member 3A 77.28(n)
    92.83(a)
      550267  NM_001017604.2  NP_001017604.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Klp64D1 , 3 microtubule-based movement kinesin motor3
    Kinesin-like protein at 64D1
    80(a)
    (best of 4)3
    58.83(n)1
    61.07(a)1
      64D13
    386111  NM_079210.11  NP_523934.11 
    worm
    (Caenorhabditis elegans)
    Secernentea klp-113
    klp-201
    Expression: sensory neurons, dorsal nerve
    cord, more3
    Protein KLP-201
    47(a)
    (best of 2)3
    57.71(n)1
    58.45(a)1
      IV(8756921-8762182)3
    35650571  NM_064777.31  NP_497178.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SMY11 Smy1p 44.01(n)
    29.71(a)
      853783   NP_012844.1 


    ENSEMBL Gene Tree for KIF3A (if available)
    TreeFam Gene Tree for KIF3A (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KIF3A gene
    KIF5C2  KIF21A2  KIF112  KIF3B2  KIF21B2  KIF92  KIF172  KIF4B2  
    KIF272  KIF4A2  KIF5B2  KIF62  KIF152  CENPE2  KIF5A2  KIF72  
    KIF3C2  
    18/37 SIMAP similar genes for KIF3A using alignment to 9 protein entries:     KIF3A_HUMAN (see all proteins) (see all similar genes):
    KIF3B    KIF3C    DKFZp686G1646    KIF17    KIFC3    KIF15
    KIF13A    KIF13B    KIF5C    KIF1A    KIF1B    KIF1Bbeta
    KIF7    KIF5A    CENPE    KIF16B    KIF5B    KIF22

    KIF3A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for KIF3A
    PGOHUM00000238313


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/733 NCBI SNPs in KIF3A are shown (see all 733    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1924278341,2
    --132027903(+) GGAGCC/TAAATG 1 -- ds50010--------
    rs1839205371,2
    --132027926(+) GAACAC/TGAAGA 1 -- ds50010--------
    rs556964331,2
    C,--132027927(+) AACACG/AAAGAA 1 -- ds50013Minor allele frequency- A:0.07WA 122
    rs1884097241,2
    --132027984(+) AGGGAA/GAAGAG 1 -- ds50010--------
    rs1146425901,2
    F,--132027989(+) GAAGAG/ACAGAA 1 -- ds50011Minor allele frequency- A:0.02NA 120
    rs1812137361,2
    --132028099(+) TGTACC/TGCCAA 1 -- ds50010--------
    rs1386415791,2
    --132028153(+) CTTCAC/TGATTT 1 -- ds50010--------
    rs1493259771,2
    --132028185(+) TTAAGC/TGTTTC 1 -- ds50010--------
    rs1435783461,2
    --132028283(+) ACCACA/GAAGAT 1 -- ds50010--------
    rs115457221,2
    C--132028540(+) TATAAG/ATTCAA 1 -- ut311Minor allele frequency- A:0.00NA 2

    HapMap Linkage Disequilibrium report for KIF3A (132028323 - 132073330 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for KIF3A
         1 CNV: 51571

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIF3A
    DNA2.0 Custom Variant and Variant Library Synthesis for KIF3A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    KIF3A for disorders           About GeneDecksing

    OMIM gene information: 604683    OMIM disorders: --

    20/23 diseases for KIF3A (see all 23):    About MalaCards
    familial juvenile hyperuricemic nephropathy    bardet-biedl syndrome    situs inversus    familial adenomatous polyposis
    hyperuricemic nephropathy    gardner syndrome    orofaciodigital syndrome    polycystic kidney disease
    retinitis pigmentosa    kaposi's sarcoma    cystic kidney    was-related disorders
    polyposis    kidney disease    sarcoma    retinitis
    nephropathy    asthma    schizophrenia    tuberculosis

    3 diseases from the University of Copenhagen DISEASES database for KIF3A:
    Polycystic kidney disease     Orofaciodigital syndrome     Cystic kidney
    Human Genome Epidemiology (HuGE) Navigator: KIF3A (4 documents)

    Export disorders for KIF3A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KIF3A gene, integrated from 9 sources (see all 61):
    (articles sorted by number of sources associating them with KIF3A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)1, 2 Schmutz J.... Rubin E.M. (2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Photoreceptor localization of the KIF3A and KIF3B subunits of the heterotrimeric microtubule motor kinesin II in vertebrate retina. (PubMed id 10548469)1, 2 Whitehead J.L....Burnside B. (1999)
    4. A theory of evolution above the species level. (PubMed id 1054846)1, 3 Stanley S.M. (1975)
    5. Visualization of translated tau protein in the axons of neuronal P19 cells and characterization of tau RNP granules. (PubMed id 12235292)1, 9 Aronov S....Ginzburg I. (2002)
    6. Role of the kinesin-2 family protein, KIF3, during mitosis. (PubMed id 16298999)1, 9 Haraguchi K....Akiyama T. (2006)
    7. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    8. Meta-analysis of genome-wide association studies ident ifies three new risk loci for atopic dermatitis. (PubMed id 22197932)1 Paternoster L....Weidinger S. (2012)
    9. Neuronal ceroid lipofuscinosis protein CLN3 interacts with motor proteins and modifies location of late endosomal compartments. (PubMed id 22261744)2 Uusi-Rauva K.... Jalanko A. (2012)
    10. NOTCH1 nuclear interactome reveals key regulators of i ts transcriptional activity and oncogenic function. (PubMed id 23022380)1 Yatim A....Benkirane M. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11127 HGNC: 6319 AceView: KIF3A Ensembl:ENSG00000131437 euGenes: HUgn11127
    ECgene: KIF3A H-InvDB: KIF3A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KIF3A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KIF3A gene:
    Search GeneIP for patents involving KIF3A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of KIF3A
     Browse Small Molecules at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for KIF3A   OriGene shRNA RFP for KIF3A  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KIF3A   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIF3A  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for KIF3A   OriGene 3'-UTR Clone for KIF3A  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIF3A   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIF3A  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KIF3A   OriGene Custom Protein Services for KIF3A  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KIF3A
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIF3A
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIF3A
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIF3A
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIF3A
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIF3A
     GenScript Custom Purified and Recombinant Proteins Services for KIF3A GenScript cDNA clones with any tag delivered in your preferred vector for KIF3A
     GenScript Custom Assay Services for KIF3A GenScript Custom Superior Antibodies Services for KIF3A
     GenScript Custom overexpressing Cell Line Services for KIF3A CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for KIF3A 

     Regulatory tfbs in KIF3A promoter
     Search Chromatin IP Primers for KIF3A
     RT2 qPCR Primer Assay in human, mouse, rat KIF3A
     GNC Network for KIF3A
     SABiosciences PCR Arrays including human, mouse, rat KIF3A
     Search Tocris compounds for KIF3A
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     KIF3A antibodies
     KIF3A proteins
     KIF3A lysates
     Antibodies for KIF3A
     See all of Abcam's Antibodies, Kits and Proteins for KIF3A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     KIF3A Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for KIF3A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF3A
     SwitchGear 3'UTR luciferase reporter plasmids for KIF3A
     SwitchGear Promoter luciferase reporter plasmids for KIF3A
     Search ThermoFisher Antibodies for KIF3A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIF3A
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KIF3A gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4