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Aliases for KIF3A Gene

Aliases for KIF3A Gene

  • Kinesin Family Member 3A 2 3 5
  • Microtubule Plus End-Directed Kinesin Motor 3A 3 4
  • Kinesin Family Protein 3A 2 3
  • Kinesin-Like Protein KIF3A 3
  • KLP-20 3
  • FLA10 3
  • KIF3 4

External Ids for KIF3A Gene

Previous GeneCards Identifiers for KIF3A Gene

  • GC05M131554
  • GC05M132479
  • GC05M132064
  • GC05M132107
  • GC05M132059
  • GC05M127220

Summaries for KIF3A Gene

GeneCards Summary for KIF3A Gene

KIF3A (Kinesin Family Member 3A) is a Protein Coding gene. Diseases associated with KIF3A include Retinitis Pigmentosa. Among its related pathways are Immune System and Organelle biogenesis and maintenance. GO annotations related to this gene include ATPase activity and microtubule binding. An important paralog of this gene is KIF3B.

UniProtKB/Swiss-Prot for KIF3A Gene

  • Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitement of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole.

Gene Wiki entry for KIF3A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF3A Gene

Genomics for KIF3A Gene

Regulatory Elements for KIF3A Gene

Enhancers for KIF3A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F132770 1.3 Ensembl ENCODE 12.4 -36.9 -36865 7.9 HDGF PKNOX1 ARID4B SIN3A ZNF48 YY1 GLIS2 CBX5 GATA2 ZNF143 SEPT8 CCNI2 KIF3A RAD50 ENSG00000224431 SOWAHA SHROOM1 TH2LCRR IL13 IL4
GH05F132767 1.2 Ensembl ENCODE 11.9 -30.4 -30352 1.6 ATF1 PKNOX1 ARNT CREB3L1 ZNF766 GATA2 FOS JUNB NCOA1 TBX21 SEPT8 CCNI2 KIF3A SHROOM1 SOWAHA TH2LCRR IL4 RNU7-15P RNA5SP192 ENSG00000230612
GH05F132818 1.2 Ensembl ENCODE 10.7 -82.2 -82165 2.2 ELF3 HDAC1 CBX3 ATF1 TBL1XR1 WRNIP1 ARID4B ZNF2 RAD21 YY1 GDF9 RNU7-15P RNA5SP192 UQCRQ CCNI2 KIF3A IL4 ENSG00000230612 SHROOM1 ENSG00000272203
GH05F132674 1.1 Ensembl ENCODE 11.5 +62.7 62738 1.8 HDGF PKNOX1 SIN3A BMI1 GATA2 SCRT2 FOS CREM EGR2 ZNF263 KIF3A IL4 LOC105379176
GH05F132812 0.9 ENCODE 11 -78.0 -77965 5.4 CBX3 YY1 GLIS2 EGR2 ZNF202 ZNF263 ZNF362 ZNF280D CEBPB ZEB2 IL4 GDF9 RAD50 AFF4 RNU7-15P RNA5SP192 CCNI2 UQCRQ KIF3A ZCCHC10
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KIF3A on UCSC Golden Path with GeneCards custom track

Promoters for KIF3A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001290166 238 1201 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF48 BRCA1 ZNF2 YY1 GLIS2

Genomic Location for KIF3A Gene

Chromosome:
5
Start:
132,689,161 bp from pter
End:
132,737,638 bp from pter
Size:
48,478 bases
Orientation:
Minus strand

Genomic View for KIF3A Gene

Genes around KIF3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF3A Gene

Proteins for KIF3A Gene

  • Protein details for KIF3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y496-KIF3A_HUMAN
    Recommended name:
    Kinesin-like protein KIF3A
    Protein Accession:
    Q9Y496
    Secondary Accessions:
    • A8MSW9
    • Q59EN1
    • Q86XE9
    • Q9Y6V4

    Protein attributes for KIF3A Gene

    Size:
    699 amino acids
    Molecular mass:
    80041 Da
    Quaternary structure:
    • Heterodimer of KIF3A and KIF3B (By similarity). Interacts with PIFO (PubMed:20643351). Interacts with CLN3 (PubMed:22261744). Interacts with DCTN1 (By similarity).
    SequenceCaution:
    • Sequence=AAC04475.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAD93017.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for KIF3A Gene

Post-translational modifications for KIF3A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for KIF3A (KIF3A)
  • Abcam antibodies for KIF3A

No data available for DME Specific Peptides for KIF3A Gene

Domains & Families for KIF3A Gene

Gene Families for KIF3A Gene

Protein Domains for KIF3A Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y496

UniProtKB/Swiss-Prot:

KIF3A_HUMAN :
  • Contains 1 kinesin motor domain.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.
Domain:
  • Contains 1 kinesin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.
genes like me logo Genes that share domains with KIF3A: view

Function for KIF3A Gene

Molecular function for KIF3A Gene

GENATLAS Biochemistry:
kinesin heavy chain member 3-like,mouse Kif3 homolog,putative microtubule associated motor protein,ATP dependent superfamily,N type,involved in anterograde transport of membranous organelles,distinct from synaptic vesicles
UniProtKB/Swiss-Prot Function:
Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitement of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole.

Gene Ontology (GO) - Molecular Function for KIF3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity IEA --
GO:0005515 protein binding IPI 16298999
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed TAS 16298999
genes like me logo Genes that share ontologies with KIF3A: view
genes like me logo Genes that share phenotypes with KIF3A: view

Animal Models for KIF3A Gene

MGI Knock Outs for KIF3A:

Animal Model Products

miRNA for KIF3A Gene

miRTarBase miRNAs that target KIF3A

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KIF3A Gene

Localization for KIF3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF3A Gene

Cytoplasm, cytoskeleton. Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localizes to the subdistal appendage region of the centriole. {ECO:0000269 PubMed:23386061}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIF3A gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 5
nucleus 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for KIF3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 16298999
GO:0005814 centriole IEA,IDA 23386061
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with KIF3A: view

Pathways & Interactions for KIF3A Gene

genes like me logo Genes that share pathways with KIF3A: view

SIGNOR curated interactions for KIF3A Gene

Is activated by:

Gene Ontology (GO) - Biological Process for KIF3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0001822 kidney development IEA --
GO:0001947 heart looping IEA --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS --
GO:0006996 organelle organization TAS 1447303
genes like me logo Genes that share ontologies with KIF3A: view

Transcripts for KIF3A Gene

Unigene Clusters for KIF3A Gene

Kinesin family member 3A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF3A Gene

No ASD Table

Relevant External Links for KIF3A Gene

GeneLoc Exon Structure for
KIF3A
ECgene alternative splicing isoforms for
KIF3A

Expression for KIF3A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KIF3A Gene

mRNA differential expression in normal tissues according to GTEx for KIF3A Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x4.4) and Brain - Frontal Cortex (BA9) (x4.3).

Protein differential expression in normal tissues from HIPED for KIF3A Gene

This gene is overexpressed in Brain (19.7), Testis (8.0), Fetal Brain (8.0), and Frontal cortex (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KIF3A Gene



Protein tissue co-expression partners for KIF3A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KIF3A Gene:

KIF3A

SOURCE GeneReport for Unigene cluster for KIF3A Gene:

Hs.43670
genes like me logo Genes that share expression patterns with KIF3A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for KIF3A Gene

Orthologs for KIF3A Gene

This gene was present in the common ancestor of animals.

Orthologs for KIF3A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF3A 34 35
  • 99.14 (n)
dog
(Canis familiaris)
Mammalia KIF3A 34 35
  • 95.28 (n)
cow
(Bos Taurus)
Mammalia KIF3A 34 35
  • 95.14 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KIF3A 35
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kif3a 34
  • 87.32 (n)
mouse
(Mus musculus)
Mammalia Kif3a 34 16 35
  • 86.98 (n)
oppossum
(Monodelphis domestica)
Mammalia KIF3A 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIF3A 34 35
  • 81.69 (n)
lizard
(Anolis carolinensis)
Reptilia KIF3A 35
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kif3a 34
  • 79.26 (n)
Str.3700 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.625 34
zebrafish
(Danio rerio)
Actinopterygii KIF3A (1 of 2) 35
  • 92 (a)
OneToMany
kif3a 34 35
  • 77.14 (n)
fruit fly
(Drosophila melanogaster)
Insecta Klp64D 36 34 35
  • 59.13 (n)
Klp68D 36
  • 44 (a)
Kif3C 36
  • 39 (a)
nod 36
  • 36 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002427 34
  • 57.15 (n)
worm
(Caenorhabditis elegans)
Secernentea klp-20 34 35
  • 57.71 (n)
klp-11 36
  • 47 (a)
osm-3 36
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 66 (a)
OneToOne
Species where no ortholog for KIF3A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIF3A Gene

ENSEMBL:
Gene Tree for KIF3A (if available)
TreeFam:
Gene Tree for KIF3A (if available)

Paralogs for KIF3A Gene

Pseudogenes.org Pseudogenes for KIF3A Gene

genes like me logo Genes that share paralogs with KIF3A: view

Variants for KIF3A Gene

Sequence variations from dbSNP and Humsavar for KIF3A Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10036532 -- 132,710,123(+) ATTCT(G/T)ATCAT intron-variant
rs10043403 -- 132,688,491(+) ggcaa(C/T)ttagc downstream-variant-500B
rs10045170 -- 132,708,307(+) aaaGA(A/G)CTTTT intron-variant
rs10052500 -- 132,724,808(+) aaaAa(A/T)atata intron-variant
rs10052512 -- 132,724,857(+) TATAT(A/T)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF3A Gene

Variant ID Type Subtype PubMed ID
nsv950393 CNV duplication 24416366
nsv529021 CNV loss 19592680
nsv521072 CNV loss 19592680
nsv1114729 CNV deletion 24896259
esv3570417 CNV loss 25503493
dgv1646e212 CNV loss 25503493

Variation tolerance for KIF3A Gene

Residual Variation Intolerance Score: 8.89% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.01; 93.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIF3A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIF3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF3A Gene

Disorders for KIF3A Gene

MalaCards: The human disease database

(1) MalaCards diseases for KIF3A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association - COSMIC cancer census association via MalaCards
Search KIF3A in MalaCards View complete list of genes associated with diseases

Relevant External Links for KIF3A

Genetic Association Database (GAD)
KIF3A
Human Genome Epidemiology (HuGE) Navigator
KIF3A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIF3A
genes like me logo Genes that share disorders with KIF3A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIF3A Gene

Publications for KIF3A Gene

  1. Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages. (PMID: 23386061) Kodani A. … Reiter J.F. (EMBO J. 2013) 3 4 64
  2. Neuronal ceroid lipofuscinosis protein CLN3 interacts with motor proteins and modifies location of late endosomal compartments. (PMID: 22261744) Uusi-Rauva K. … Jalanko A. (Cell. Mol. Life Sci. 2012) 3 4 64
  3. Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. (PMID: 22197932) Paternoster L. … Weidinger S. (Nat. Genet. 2012) 3 46 64
  4. Pitchfork regulates primary cilia disassembly and left-right asymmetry. (PMID: 20643351) Kinzel D. … Lickert H. (Dev. Cell 2010) 3 4 64
  5. Association analysis of susceptibility candidate region on chromosome 5q31 for tuberculosis. (PMID: 20485362) Ridruechai C. … Tokunaga K. (Genes Immun. 2010) 3 46 64

Products for KIF3A Gene

Sources for KIF3A Gene

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