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Aliases for KIF3A Gene

Aliases for KIF3A Gene

  • Kinesin Family Member 3A 2 3 5
  • Microtubule Plus End-Directed Kinesin Motor 3A 3 4
  • Kinesin Family Protein 3A 2 3
  • KLP-20 3
  • FLA10 3
  • KIF3 4

External Ids for KIF3A Gene

Previous GeneCards Identifiers for KIF3A Gene

  • GC05M131554
  • GC05M132479
  • GC05M132064
  • GC05M132107
  • GC05M132059
  • GC05M127220

Summaries for KIF3A Gene

GeneCards Summary for KIF3A Gene

KIF3A (Kinesin Family Member 3A) is a Protein Coding gene. Diseases associated with KIF3A include retinitis pigmentosa. Among its related pathways are Platelet activation, signaling and aggregation and Signaling by GPCR. GO annotations related to this gene include ATPase activity and microtubule binding. An important paralog of this gene is KIF14.

UniProtKB/Swiss-Prot for KIF3A Gene

  • Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation (By similarity).

Gene Wiki entry for KIF3A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF3A Gene

Genomics for KIF3A Gene

Regulatory Elements for KIF3A Gene

Promoters for KIF3A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KIF3A on UCSC Golden Path with GeneCards custom track

Genomic Location for KIF3A Gene

Chromosome:
5
Start:
132,689,161 bp from pter
End:
132,737,638 bp from pter
Size:
48,478 bases
Orientation:
Minus strand

Genomic View for KIF3A Gene

Genes around KIF3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF3A Gene

Proteins for KIF3A Gene

  • Protein details for KIF3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y496-KIF3A_HUMAN
    Recommended name:
    Kinesin-like protein KIF3A
    Protein Accession:
    Q9Y496
    Secondary Accessions:
    • A8MSW9
    • Q59EN1
    • Q86XE9
    • Q9Y6V4

    Protein attributes for KIF3A Gene

    Size:
    699 amino acids
    Molecular mass:
    80041 Da
    Quaternary structure:
    • Heterodimer of KIF3A and KIF3B. Interacts with PIFO. Interacts with CLN3.
    SequenceCaution:
    • Sequence=AAC04475.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAD93017.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for KIF3A Gene

Proteomics data for KIF3A Gene at MOPED

Post-translational modifications for KIF3A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for KIF3A (KIF3A)

No data available for DME Specific Peptides for KIF3A Gene

Domains & Families for KIF3A Gene

Gene Families for KIF3A Gene

Protein Domains for KIF3A Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y496

UniProtKB/Swiss-Prot:

KIF3A_HUMAN :
  • Contains 1 kinesin motor domain.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.
Domain:
  • Contains 1 kinesin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.
genes like me logo Genes that share domains with KIF3A: view

Function for KIF3A Gene

Molecular function for KIF3A Gene

GENATLAS Biochemistry:
kinesin heavy chain member 3-like,mouse Kif3 homolog,putative microtubule associated motor protein,ATP dependent superfamily,N type,involved in anterograde transport of membranous organelles,distinct from synaptic vesicles
UniProtKB/Swiss-Prot Function:
Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation (By similarity).

Gene Ontology (GO) - Molecular Function for KIF3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with KIF3A: view
genes like me logo Genes that share phenotypes with KIF3A: view

Animal Models for KIF3A Gene

MGI Knock Outs for KIF3A:

Animal Model Products

  • Taconic Biosciences Mouse Models for KIF3A

miRNA for KIF3A Gene

miRTarBase miRNAs that target KIF3A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KIF3A Gene

Localization for KIF3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF3A Gene

Cytoplasm, cytoskeleton. Cell projection, cilium.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIF3A Gene COMPARTMENTS Subcellular localization image for KIF3A gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
nucleus 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for KIF3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005876 colocalizes_with spindle microtubule IDA 16298999
GO:0031512 motile primary cilium IEA --
GO:0032391 photoreceptor connecting cilium IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with KIF3A: view

Pathways & Interactions for KIF3A Gene

genes like me logo Genes that share pathways with KIF3A: view

SIGNOR curated interactions for KIF3A Gene

Is activated by:

Gene Ontology (GO) - Biological Process for KIF3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS --
GO:0006996 organelle organization TAS 1447303
GO:0007368 determination of left/right symmetry IEA --
GO:0007596 blood coagulation TAS --
GO:0009953 dorsal/ventral pattern formation IEA --
genes like me logo Genes that share ontologies with KIF3A: view

Drugs & Compounds for KIF3A Gene

No Compound Related Data Available

Transcripts for KIF3A Gene

Unigene Clusters for KIF3A Gene

Kinesin family member 3A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIF3A Gene

No ASD Table

Relevant External Links for KIF3A Gene

GeneLoc Exon Structure for
KIF3A
ECgene alternative splicing isoforms for
KIF3A

Expression for KIF3A Gene

mRNA expression in normal human tissues for KIF3A Gene

mRNA differential expression in normal tissues according to GTEx for KIF3A Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x4.4) and Brain - Frontal Cortex (BA9) (x4.3).

Protein differential expression in normal tissues from HIPED for KIF3A Gene

This gene is overexpressed in Brain (19.7), Testis (8.0), Fetal Brain (8.0), and Frontal cortex (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIF3A Gene



SOURCE GeneReport for Unigene cluster for KIF3A Gene Hs.43670

genes like me logo Genes that share expression patterns with KIF3A: view

Protein tissue co-expression partners for KIF3A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for KIF3A Gene

Orthologs for KIF3A Gene

This gene was present in the common ancestor of animals.

Orthologs for KIF3A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF3A 36
  • 96 (a)
OneToOne
KIF3A 35
  • 99.14 (n)
  • 99 (a)
cow
(Bos Taurus)
Mammalia KIF3A 36
  • 95 (a)
OneToOne
KIF3A 35
  • 95.14 (n)
  • 99.14 (a)
dog
(Canis familiaris)
Mammalia KIF3A 35
  • 95.28 (n)
  • 99 (a)
KIF3A 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kif3a 36
  • 97 (a)
OneToOne
Kif3a 16
Kif3a 35
  • 86.98 (n)
  • 96.57 (a)
oppossum
(Monodelphis domestica)
Mammalia KIF3A 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF3A 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kif3a 35
  • 87.32 (n)
  • 97.14 (a)
chicken
(Gallus gallus)
Aves KIF3A 35
  • 81.69 (n)
  • 94.85 (a)
KIF3A 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIF3A 36
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.625 35
tropical clawed frog
(Silurana tropicalis)
Amphibia kif3a 35
  • 79.26 (n)
  • 91.99 (a)
Str.3700 35
zebrafish
(Danio rerio)
Actinopterygii kif3a 35
  • 77.14 (n)
  • 92.68 (a)
kif3a 36
  • 92 (a)
OneToMany
KIF3A (1 of 2) 36
  • 92 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002427 35
  • 57.15 (n)
  • 62.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta Klp64D 36
  • 58 (a)
OneToOne
Kif3C 37
  • 39 (a)
Klp64D 37
  • 80 (a)
Klp68D 37
  • 44 (a)
nod 37
  • 36 (a)
Klp64D 35
  • 59.13 (n)
  • 61.08 (a)
worm
(Caenorhabditis elegans)
Secernentea klp-11 37
  • 47 (a)
osm-3 37
  • 39 (a)
klp-20 36
  • 56 (a)
OneToOne
klp-20 35
  • 57.71 (n)
  • 58.29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 66 (a)
OneToOne
Species with no ortholog for KIF3A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIF3A Gene

ENSEMBL:
Gene Tree for KIF3A (if available)
TreeFam:
Gene Tree for KIF3A (if available)

Paralogs for KIF3A Gene

Pseudogenes.org Pseudogenes for KIF3A Gene

genes like me logo Genes that share paralogs with KIF3A: view

Variants for KIF3A Gene

Sequence variations from dbSNP and Humsavar for KIF3A Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs17854353 - 132,720,710(+) TTTCT(A/T)TAACC reference, missense
rs1060980 -- 132,694,100(-) TATAG(A/C)AGTTT intron-variant, utr-variant-3-prime
rs1062247 -- 132,693,704(-) acgcc(C/T)ggccT intron-variant, utr-variant-3-prime
rs1468216 -- 132,700,560(-) GGAAC(A/G)TGGTC intron-variant
rs2051809 -- 132,721,182(-) TCCTA(G/T)ATAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF3A Gene

Variant ID Type Subtype PubMed ID
dgv6335n71 CNV Loss 21882294
nsv529021 CNV Loss 19592680
nsv882918 CNV Loss 21882294
nsv521072 CNV Loss 19592680

Variation tolerance for KIF3A Gene

Residual Variation Intolerance Score: 8.89% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.01; 93.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIF3A Gene

HapMap Linkage Disequilibrium report
KIF3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF3A Gene

Disorders for KIF3A Gene

MalaCards: The human disease database

(1) MalaCards diseases for KIF3A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association - COSMIC cancer census association via MalaCards
Search KIF3A in MalaCards View complete list of genes associated with diseases

Relevant External Links for KIF3A

Genetic Association Database (GAD)
KIF3A
Human Genome Epidemiology (HuGE) Navigator
KIF3A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIF3A
genes like me logo Genes that share disorders with KIF3A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIF3A Gene

Publications for KIF3A Gene

  1. Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. (PMID: 22197932) Paternoster L. … Weidinger S. (Nat. Genet. 2012) 3 48 67
  2. Role of the kinesin-2 family protein, KIF3, during mitosis. (PMID: 16298999) Haraguchi K. … Akiyama T. (J. Biol. Chem. 2006) 3 23
  3. Visualization of translated tau protein in the axons of neuronal P19 cells and characterization of tau RNP granules. (PMID: 12235292) Aronov S. … Ginzburg I. (J. Cell. Sci. 2002) 3 23
  4. A theory of evolution above the species level. (PMID: 1054846) Stanley S.M. (Proc. Natl. Acad. Sci. U.S.A. 1975) 2 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for KIF3A Gene

Sources for KIF3A Gene

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