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KIF2C Gene

protein-coding   GIFtS: 61
GCID: GC01P045208

Kinesin Family Member 2C

(Previous name: kinesin-like 6 (mitotic centromere-associated kinesin))
(Previous symbol: KNSL6)
  Search for KIF2C
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kinesin Family Member 2C1 2     Kinesin-Like 6 (Mitotic Centromere-Associated Kinesin)1
KNSL61 2 3 5     CT1392
MCAK2 3 5     Kinesin-Like 62
Kinesin-Like Protein 62 3     Kinesin-Like Protein KIF2C2
Mitotic Centromere-Associated Kinesin2 3     

External Ids:    HGNC: 63931   Entrez Gene: 110042   Ensembl: ENSG000001429457   OMIM: 6045385   UniProtKB: Q996613   

Export aliases for KIF2C gene to outside databases

Previous GC identifers: GC01P044205 GC01P044635 GC01P044618 GC01P044874 GC01P044978 GC01P043319


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KIF2C Gene:
The protein encoded by this gene is a member of kinesin-like protein family. Proteins of this family are
microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell
division. This protein is important for anaphase chromosome segregation and may be required to coordinate the
onset of sister centromere separation. (provided by RefSeq, Jul 2008)

GeneCards Summary for KIF2C Gene:
KIF2C (kinesin family member 2C) is a protein-coding gene. GO annotations related to this gene include microtubule motor activity and centromeric DNA binding. An important paralog of this gene is KIF2A.

UniProtKB/Swiss-Prot: KIF2C_HUMAN, Q99661
Function: In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic
cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during
mitosis

Gene Wiki entry for KIF2C Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the KIF2C gene promoter:
         TBP   ER-alpha   Spz1   AML1a   ATF-2   C/EBPalpha   Egr-4   YY1   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKIF2C promoter sequence
   Search Chromatin IP Primers for KIF2C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KIF2C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.1   Ensembl cytogenetic band:  1p34.1   HGNC cytogenetic band: 1p34.1

KIF2C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIF2C gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P045208:  view genomic region     (about GC identifiers)

Start:
45,205,490 bp from pter      End:
45,233,439 bp from pter
Size:
27,950 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KIF2C_HUMAN, Q99661 (See protein sequence)
Recommended Name: Kinesin-like protein KIF2C  
Size: 725 amino acids; 81313 Da
Subunit: Interacts with CENPH. Interacts with MTUS2/TIP150; the interaction is direct. Interacts with MAPRE1; the
interaction is direct, regulated by phosphorylation and is probably required for targeting to growing microtubule
plus ends. Interacts with KIF18B at microtubule tips; this interaction increases the affinity of both partners
for microtubule plus ends and is required for robust microtubule depolymerization. Phosphorylation by AURKA or
AURKB strongly reduces KIF18B-binding
Developmental stage: Isoform 2 is expressed in fetal testis
1 PDB 3D structure from and Proteopedia for KIF2C:
2HEH (3D)    
Secondary accessions: B3ITR9 Q5JR88 Q6ICU1 Q96C18 Q96HB8 Q9BWV8
Alternative splicing: 2 isoforms:  Q99661-1   Q99661-2   

Explore the universe of human proteins at neXtProt for KIF2C: NX_Q99661

Explore proteomics data for KIF2C at MOPED

Post-translational modifications: 

  • Phosphorylation by AURKB, regulates association with centromeres and kinetochores and the microtubule
    depolymerization activity1
  • Ubiquitinated1
  • Ubiquitination2 at Lys38, Lys365, Lys487, Lys518
  • Modification sites at PhosphoSitePlus

  • See KIF2C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006836.2  
    ENSEMBL proteins: 
     ENSP00000410346   ENSP00000361298   ENSP00000395050   ENSP00000361291   ENSP00000402172  
     ENSP00000361292   ENSP00000361296  
    Reactome Protein details: Q99661

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KIF: Kinesins

    4 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR001752 Kinesin_motor_dom
     IPR019821 Kinesin_motor_CS
     IPR027640 Kinesin-like_fam

    Graphical View of Domain Structure for InterPro Entry Q99661

    ProtoNet protein and cluster: Q99661

    1 Blocks protein domain: IPB001752 Kinesin

    UniProtKB/Swiss-Prot: KIF2C_HUMAN, Q99661
    Domain: The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to
    the growing microtubule plus ends
    Similarity: Belongs to the kinesin-like protein family. MCAK/KIF2 subfamily
    Similarity: Contains 1 kinesin-motor domain


    Find genes that share domains with KIF2C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KIF2C_HUMAN, Q99661
    Function: In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic
    cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during
    mitosis

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003777microtubule motor activity IEA--
    GO:0005515protein binding IPI11092768
    GO:0005524ATP binding IEA--
    GO:0008017microtubule binding ----
    GO:0019237centromeric DNA binding TAS9434124
         
    Find genes that share ontologies with KIF2C           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for KIF2C:
     Synthetic lethal with Ras 

    Animal Models:
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    3 qRT-PCR Assays for microRNAs that regulate KIF2C:
    hsa-miR-2355-5p hsa-miR-186* hsa-miR-3915
    SwitchGear 3'UTR luciferase reporter plasmidKIF2C 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KIF2C_HUMAN, Q99661: Cytoplasm, cytoskeleton (By similarity). Nucleus (By similarity). Chromosome, centromere.
    Chromosome, centromere, kinetochore. Note=Associates with the microtubule network at the growing distal tip (the
    plus-end) of microtubules, probably through interaction with MTUS2/TIP150 and MAPRE1 (By similarity). Association
    with microtubule plus ends is also mediated by interaction with KIF18B. Centromeric localization requires the
    presence of BUB1 and SGOL2
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol4
    mitochondrion2
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region IDA14960279
    GO:0000776colocalizes with kinetochore IDA14960279
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with KIF2C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KIF2C About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    3Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Resolution of Sister Chromatid Cohesion0.92
    4Hemostasis
    Hemostasis0.43
    5Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41


    Find genes that share SuperPaths with KIF2C           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for KIF2C
        Reelin Pathway (Cajal-Retzius cells)

    2 BioSystems Pathways for KIF2C
        Aurora B signaling
    Regulation of Microtubule Cytoskeleton


    5 Reactome Pathways for KIF2C
        Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Separation of Sister Chromatids
    MHC class II antigen presentation
    Kinesins


        Pathway & Disease-focused RT2 Profiler PCR Array including KIF2C: 
              T Helper Cell Differentiation in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for KIF2C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KIF2C (Q996611, 2, 3 ENSP000003612984) via UniProtKB, MINT, STRING, and/or I2D (see all 869)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MTUS2Q5JR591, 2, 3EBI-1642317,EBI-742948 MINT-7256299 MINT-7256258 MINT-7256235 MINT-7256361 MINT-7256216 MINT-7256202 I2D: score=1 
    MAPRE1Q156911, 2, 3, ENSP000003647214EBI-1642317,EBI-1004115 MINT-7256299 MINT-7256258 MINT-7256324 MINT-7256284 I2D: score=2 STRING: ENSP00000364721
    CSNK2BP678702, 3MINT-8253363 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8253363 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8253363 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0007018microtubule-based movement TAS--
    GO:0007019microtubule depolymerization IMP19060894
    GO:0007059chromosome segregation IEA--
    GO:0007067mitosis IEA--

    Find genes that share ontologies with KIF2C           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for KIF2C

    2 DrugBank Compounds for KIF2C    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine-5'-Diphosphate-- 20398-34-9target--17139284 17016423 10592235
    Phosphoaminophosphonic Acid-Adenylate Ester-- --target--17139284 17016423 10592235

    2 Novoseek inferred chemical compound relationships for KIF2C gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pravastatin 41.1 1 18222355 (1)
    atp 14.2 3 15304328 (3)



    Find genes that share compounds with KIF2C           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KIF2C gene: 
    NM_006845.3  

    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000452259 ENST00000372224(uc001cmg.4 uc010olb.2) ENST00000493027
    ENST00000455186 ENST00000480574 ENST00000372217(uc010olc.2 uc001cmh.4)
    ENST00000423289 ENST00000472235 ENST00000372218 ENST00000372222
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    Selected AceView cDNA sequences (see all 268):

    AU124854 AL524541 BM473109 AA346481 BM828749 BI831051 BQ430935 BC008764 
    BG478962 BC032038 CA453930 AA393163 BU527428 BE273892 BU932006 BQ649634 
    CA416354 CA454677 CA416375 BC014924 BU186303 BM753248 AU130825 BP365214 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for KIF2C    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a ·
    SP1:                    -     -     -                 -                                                                                   -                     
    SP2:                                                  -                                                                                   -                     
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                    -     -                                                                                                                                 

    ExUns: 21b ^ 22a · 22b
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for KIF2C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    KIF2C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGACACTCCT
    KIF2C Expression
    About this image


    KIF2C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord blood-derived hematopoietic stem cells
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Hepatocytes Liver Lobule
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Umbilical cord blood-derived hematopoietic stem cells
     
     Testis (Reproductive System)
             Testis Interstitium
     
     Thymus (Hematopoietic System)
             Thymus
    KIF2C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KIF2C Protein Expression

    UniProtKB/Swiss-Prot: KIF2C_HUMAN, Q99661
    Tissue specificity: Expressed at high levels in thymus and testis, at low levels in small intestine, the mucosal
    lining of colon, and placenta, and at very low levels in spleen and ovary; expression is not detected in
    prostate, peripheral blood Leukocytes, heart, brain, lung, liver, skeletal muscle, kidney or pancreas. Isoform 2
    is testis-specific

        Pathway & Disease-focused RT2 Profiler PCR Array including KIF2C: 
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for KIF2C gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kif2c1 , 5 kinesin family member 2C1, 5 87.2(n)1
    88.55(a)1
      4 (53.42 cM)5
    738041  NM_134471.41  NP_608301.31 
     1171596395 
    chicken
    (Gallus gallus)
    Aves KIF2C6
    kinesin family member 2C
    69(a)
    1 ↔ 1
    8(19641345-19661258)
    lizard
    (Anolis carolinensis)
    Reptilia KIF2C6
    kinesin family member 2C
    67(a)
    1 ↔ 1
    4(110042918-110080711)
    African clawed frog
    (Xenopus laevis)
    Amphibia kif2c-prov2 kinesin family member 2C 76.19(n)    BC044976.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.139632 Transcribed sequence with moderate similarity to protein more 76.76(n)    57046148 
    fruit fly
    (Drosophila melanogaster)
    Insecta Klp59C6
    Klp10A6
    (see all 3)
    Klp10A
    (see all 3)
    46(a)
    41(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    2R(19011517-19013565)
    X(11023395-11031056)
    worm
    (Caenorhabditis elegans)
    Secernentea klp-71 klp-7 52.53(n)
    50.27(a)
      176511  NM_001027506.2  NP_001022677.1 
    Alicante grape
    (Vitis vinifera)
    eudicotyledons Vvi.33292 Vitis vinifera transcribed sequence with moderate similarity more 79.01(n)    CF215404.1 
    rice
    (Oryza sativa)
    Liliopsida NM_185267.12   -- 79.42(n)    NM_185267.1 


    ENSEMBL Gene Tree for KIF2C (if available)
    TreeFam Gene Tree for KIF2C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KIF2C gene
    KIF2A2  KIF242  KIF2B2  
    16 SIMAP similar genes for KIF2C using alignment to 6 protein entries:     KIF2C_HUMAN (see all proteins):
    KIF24    KIF28P    KIF2A    KIF2B    KIF18B    KIFC3
    STARD9    KIF1A    KIF13B    KIF6    KIF12    KIF27
    KIF5C    KIF3A    KIF5A    KIF5B

    Find genes that share paralogs with KIF2C           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for KIF2C
    PGOHUM00000244754


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KIF2C (see all 673)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1121036531,2
    C,F--45203586(+) GAGGCG/CGGGCT 1 -- us2k11Minor allele frequency- C:0.50NA 2
    rs597887231,2
    C--45203672(+) CAGCCC/TGGGCA 1 -- us2k10--------
    rs3691929581,2
    C--45203739(+) CCCCT-/CCC   
       CCCTC
    CTCCC
    1 -- us2k10--------
    rs1117989281,2
    C--45203741(+) CCCTCC/TCCCCG 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1899669491,2
    --45203784(+) GTACTC/GCCGCC 1 -- us2k10--------
    rs1121089771,2
    F--45203859(+) GCAGGT/CGCGCG 1 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs1866283881,2
    --45203867(+) GCGCCA/GCCGCA 1 -- us2k10--------
    rs617899381,2
    C,F--45203955(+) GAGTGG/ATCTGC 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1910371751,2
    C--45204276(+) GGATCA/GTCTCT 1 -- us2k10--------
    rs1839303441,2
    C--45204290(+) TGGCCA/GCCCCG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KIF2C (45205490 - 45233439 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for KIF2C:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv461406CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KIF2C
    DNA2.0 Custom Variant and Variant Library Synthesis for KIF2C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604538    OMIM disorders: --


    Find genes that share disorders with KIF2C           About GenesLikeMe

    1 Novoseek inferred disease relationship for KIF2C gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myocardial infarction 0 1 18222353 (1)

    Genetic Association Database (GAD): KIF2C
    Human Genome Epidemiology (HuGE) Navigator: KIF2C (1 document)

    Export disorders for KIF2C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KIF2C gene, integrated from 10 sources (see all 104):
    (articles sorted by number of sources associating them with KIF2C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of human mitotic centromere-associated kinesin gene. (PubMed id 9434124)1, 2, 3, 9 Kim I.-G.... Kim Y.H. (Biochim. Biophys. Acta 1997)
    2. Aurora B regulates MCAK at the mitotic centromere. (PubMed id 14960279)1, 2, 9 Andrews P.D.... Swedlow J.R. (Dev. Cell 2004)
    3. TIP150 interacts with and targets MCAK at the microtubule plus ends. (PubMed id 19543227)1, 2, 9 Jiang K....Yao X. (EMBO Rep. 2009)
    4. Genome stability is ensured by temporal control of kinetochore- microtubule dynamics. (PubMed id 19060894)1, 2, 9 Bakhoum S.F.... Compton D.A. (Nat. Cell Biol. 2009)
    5. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)
    6. A complex of Kif18b and MCAK promotes microtubule depolymerization and is negatively regulated by Aurora kinases. (PubMed id 21820309)1, 2 Tanenbaum M.E....Medema R.H. (Curr. Biol. 2011)
    7. Development and validation of a method for profiling post-translational modification activities using protein microarrays. (PubMed id 20596523)1, 2 Del RincA^n S.V....Spruck C. (PLoS ONE 2010)
    8. An EB1-binding motif acts as a microtubule tip localization signal. (PubMed id 19632184)1, 2 Honnappa S.... Steinmetz M.O. (Cell 2009)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Expression of a novel HsMCAK mRNA splice variant, tsMCAK gene, in human testis. (PubMed id 12383881)1, 2 Cheng L.J.... Sha J.H. (Life Sci. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11004 HGNC: 6393 AceView: KIF2C Ensembl:ENSG00000142945 euGenes: HUgn11004
    ECgene: KIF2C H-InvDB: KIF2C

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KIF2C Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KIF2C Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KIF2C gene:
    Search GeneIP for patents involving KIF2C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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