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Aliases for KIF2C Gene

Aliases for KIF2C Gene

  • Kinesin Family Member 2C 2 3
  • KNSL6 3 4 6
  • MCAK 3 4 6
  • Mitotic Centromere-Associated Kinesin 3 4
  • Kinesin-Like Protein 6 3 4
  • Kinesin-Like 6 (Mitotic Centromere-Associated Kinesin) 2
  • Kinesin-Like Protein KIF2C 3
  • CT139 3

External Ids for KIF2C Gene

Previous HGNC Symbols for KIF2C Gene

  • KNSL6

Previous GeneCards Identifiers for KIF2C Gene

  • GC01P044205
  • GC01P044635
  • GC01P044618
  • GC01P044874
  • GC01P044978
  • GC01P045208
  • GC01P043319

Summaries for KIF2C Gene

Entrez Gene Summary for KIF2C Gene

  • This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for KIF2C Gene

KIF2C (Kinesin Family Member 2C) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Cell Cycle, Mitotic. GO annotations related to this gene include microtubule motor activity and centromeric DNA binding. An important paralog of this gene is KIF2B.

UniProtKB/Swiss-Prot for KIF2C Gene

  • In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis.

Gene Wiki entry for KIF2C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF2C Gene

Genomics for KIF2C Gene

Regulatory Elements for KIF2C Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KIF2C Gene

44,739,730 bp from pter
44,767,767 bp from pter
28,038 bases
Plus strand

Genomic View for KIF2C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIF2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF2C Gene

Proteins for KIF2C Gene

  • Protein details for KIF2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kinesin-like protein KIF2C
    Protein Accession:
    Secondary Accessions:
    • B3ITR9
    • Q5JR88
    • Q6ICU1
    • Q96C18
    • Q96HB8
    • Q9BWV8

    Protein attributes for KIF2C Gene

    725 amino acids
    Molecular mass:
    81313 Da
    Quaternary structure:
    • Interacts with CENPH. Interacts with MTUS2/TIP150; the interaction is direct. Interacts with MAPRE1; the interaction is direct, regulated by phosphorylation and is probably required for targeting to growing microtubule plus ends. Interacts with KIF18B at microtubule tips; this interaction increases the affinity of both partners for microtubule plus ends and is required for robust microtubule depolymerization. Phosphorylation by AURKA or AURKB strongly reduces KIF18B-binding.

    Three dimensional structures from OCA and Proteopedia for KIF2C Gene

    Alternative splice isoforms for KIF2C Gene


neXtProt entry for KIF2C Gene

Proteomics data for KIF2C Gene at MOPED

Post-translational modifications for KIF2C Gene

  • Phosphorylation by AURKB, regulates association with centromeres and kinetochores and the microtubule depolymerization activity.
  • Ubiquitinated.
  • Ubiquitination at Lys38, Lys365, Lys487, and Lys518
  • Modification sites at PhosphoSitePlus

Other Protein References for KIF2C Gene

No data available for DME Specific Peptides for KIF2C Gene

Domains for KIF2C Gene

Gene Families for KIF2C Gene

  • KIF :Kinesins

Protein Domains for KIF2C Gene

Graphical View of Domain Structure for InterPro Entry



  • Q99661
  • The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends.
  • Contains 1 kinesin motor domain.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.
genes like me logo Genes that share domains with KIF2C: view

Function for KIF2C Gene

Molecular function for KIF2C Gene

UniProtKB/Swiss-Prot Function: In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis.

Gene Ontology (GO) - Molecular Function for KIF2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity IBA --
GO:0005515 protein binding IPI 11092768
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding --
GO:0016887 ATPase activity IBA --
genes like me logo Genes that share ontologies with KIF2C: view

Phenotypes for KIF2C Gene

GenomeRNAi human phenotypes for KIF2C:
genes like me logo Genes that share phenotypes with KIF2C: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIF2C

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KIF2C Gene

Localization for KIF2C Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF2C Gene

Cytoplasm, cytoskeleton. Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Associates with the microtubule network at the growing distal tip (the plus-end) of microtubules, probably through interaction with MTUS2/TIP150 and MAPRE1 (By similarity). Association with microtubule plus ends is also mediated by interaction with KIF18B. Centromeric localization requires the presence of BUB1 and SGOL2. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for KIF2C Gene COMPARTMENTS Subcellular localization image for KIF2C gene
Compartment Confidence
cytoskeleton 4
cytosol 4
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for KIF2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IDA 14960279
GO:0000776 colocalizes_with kinetochore IDA 14960279
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with KIF2C: view

Pathways for KIF2C Gene

genes like me logo Genes that share pathways with KIF2C: view

Pathways by source for KIF2C Gene

1 Qiagen pathway for KIF2C Gene
2 BioSystems pathways for KIF2C Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • T Helper Cell Differentiation in human,mouse,rat

Gene Ontology (GO) - Biological Process for KIF2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0006200 obsolete ATP catabolic process --
GO:0007018 microtubule-based movement TAS --
GO:0007019 microtubule depolymerization IMP 19060894
GO:0007059 chromosome segregation --
genes like me logo Genes that share ontologies with KIF2C: view

Compounds for KIF2C Gene

(2) Drugbank Compounds for KIF2C Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
20398-34-9 target
Phosphoaminophosphonic Acid-Adenylate Ester

(2) Novoseek inferred chemical compound relationships for KIF2C Gene

Compound -log(P) Hits PubMed IDs
pravastatin 41.1 1
atp 14.2 3
genes like me logo Genes that share compounds with KIF2C: view

Transcripts for KIF2C Gene

Unigene Clusters for KIF2C Gene

Kinesin family member 2C:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIF2C

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF2C Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a ·
SP1: - - - - -
SP2: - -
SP5: - -

ExUns: 21b ^ 22a · 22b

Relevant External Links for KIF2C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KIF2C Gene

mRNA expression in normal human tissues for KIF2C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIF2C Gene

This gene is overexpressed in Testis (21.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIF2C Gene

SOURCE GeneReport for Unigene cluster for KIF2C Gene Hs.720061

mRNA Expression by UniProt/SwissProt for KIF2C Gene

Tissue specificity: Expressed at high levels in thymus and testis, at low levels in small intestine, the mucosal lining of colon, and placenta, and at very low levels in spleen and ovary; expression is not detected in prostate, peripheral blood Leukocytes, heart, brain, lung, liver, skeletal muscle, kidney or pancreas. Isoform 2 is testis-specific.
genes like me logo Genes that share expressions with KIF2C: view

In Situ Assay Products

Orthologs for KIF2C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KIF2C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KIF2C 35
  • 99.68 (n)
  • 99.45 (a)
KIF2C 36
  • 99 (a)
(Bos Taurus)
Mammalia KIF2C 35
  • 91.24 (n)
  • 91.29 (a)
KIF2C 36
  • 91 (a)
(Canis familiaris)
Mammalia KIF2C 35
  • 91.56 (n)
  • 91.98 (a)
KIF2C 36
  • 92 (a)
(Mus musculus)
Mammalia Kif2c 35
  • 87.2 (n)
  • 88.55 (a)
Kif2c 16
Kif2c 36
  • 88 (a)
(Monodelphis domestica)
Mammalia KIF2C 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia KIF2C 36
  • 81 (a)
(Rattus norvegicus)
Mammalia Kif2c 35
  • 86.5 (n)
  • 88.41 (a)
(Gallus gallus)
Aves KIF2C 36
  • 69 (a)
(Anolis carolinensis)
Reptilia KIF2C 36
  • 67 (a)
African clawed frog
(Xenopus laevis)
Amphibia kif2c-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia kif2c 35
  • 66 (n)
  • 67.66 (a)
Str.4037 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5588 35
(Danio rerio)
Actinopterygii Dr.13963 35
kif2c 36
  • 51 (a)
fruit fly
(Drosophila melanogaster)
Insecta Klp10A 36
  • 41 (a)
Klp59C 36
  • 46 (a)
Klp59D 36
  • 40 (a)
(Caenorhabditis elegans)
Secernentea klp-7 35
  • 52.53 (n)
  • 50.27 (a)
klp-7 36
  • 40 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3329 35
(Zea mays)
Liliopsida Zm.7332 35
(Triticum aestivum)
Liliopsida Ta.4571 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
Species with no ortholog for KIF2C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for KIF2C Gene

Gene Tree for KIF2C (if available)
Gene Tree for KIF2C (if available)

Paralogs for KIF2C Gene

Paralogs for KIF2C Gene Pseudogenes for KIF2C Gene

genes like me logo Genes that share paralogs with KIF2C: view

Variants for KIF2C Gene

Sequence variations from dbSNP and Humsavar for KIF2C Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1140279 -- 44,760,412(+) GGCGC(A/G)GACAC synonymous-codon, reference
rs1804673 -- 44,762,563(+) AGGAG(G/T)AACTG reference, stop-gained
rs3795712 -- 44,740,823(+) TTCAG(A/G)TTAAC intron-variant
rs3795713 -- 44,753,223(+) ATCCG(A/T)GGCAG intron-variant, reference, synonymous-codon
rs3795714 -- 44,758,335(+) GTATG(G/T)CAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF2C Gene

Variant ID Type Subtype PubMed ID
nsv461406 CNV Loss 19166990

Relevant External Links for KIF2C Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF2C Gene

Disorders for KIF2C Gene

(1) Novoseek inferred disease relationships for KIF2C Gene

Disease -log(P) Hits PubMed IDs
myocardial infarction 0 1

Relevant External Links for KIF2C

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with KIF2C: view

No data available for UniProtKB/Swiss-Prot for KIF2C Gene

Publications for KIF2C Gene

  1. Cloning and expression of human mitotic centromere-associated kinesin gene. (PMID: 9434124) Kim I.-G. … Kim Y.H. (Biochim. Biophys. Acta 1997) 2 3 4 23
  2. Aurora B regulates MCAK at the mitotic centromere. (PMID: 14960279) Andrews P.D. … Swedlow J.R. (Dev. Cell 2004) 3 4 23
  3. Genome stability is ensured by temporal control of kinetochore- microtubule dynamics. (PMID: 19060894) Bakhoum S.F. … Compton D.A. (Nat. Cell Biol. 2009) 3 4 23
  4. TIP150 interacts with and targets MCAK at the microtubule plus ends. (PMID: 19543227) Jiang K. … Yao X. (EMBO Rep. 2009) 3 4 23
  5. Functional and spatial regulation of mitotic centromere-associated kinesin by cyclin-dependent kinase 1. (PMID: 20368358) Sanhaji M. … Yuan J. (Mol. Cell. Biol. 2010) 3 23

Products for KIF2C Gene

  • Addgene plasmids for KIF2C

Sources for KIF2C Gene

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