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Aliases for KIF2C Gene

Aliases for KIF2C Gene

  • Kinesin Family Member 2C 2 3
  • KNSL6 3 4 6
  • MCAK 3 4 6
  • Mitotic Centromere-Associated Kinesin 3 4
  • Kinesin-Like Protein 6 3 4
  • Kinesin-Like 6 (Mitotic Centromere-Associated Kinesin) 2
  • Kinesin-Like Protein KIF2C 3
  • CT139 3

External Ids for KIF2C Gene

Previous Symbols for KIF2C Gene

  • KNSL6

Summaries for KIF2C Gene

Entrez Gene Summary for KIF2C Gene

  • This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for KIF2C Gene

KIF2C (Kinesin Family Member 2C) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Cell Cycle, Mitotic. GO annotations related to this gene include microtubule motor activity and centromeric DNA binding. An important paralog of this gene is KIF2B.

UniProtKB/Swiss-Prot for KIF2C Gene

  • In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis.

Gene Wiki entry for KIF2C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF2C Gene

Genomics for KIF2C Gene

Genomic Location for KIF2C Gene

Start:
44,739,730 bp from pter
End:
44,767,767 bp from pter
Size:
28,038 bases
Orientation:
Plus strand

Genomic View for KIF2C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIF2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF2C Gene

Regulatory Elements for KIF2C Gene

Proteins for KIF2C Gene

  • Protein details for KIF2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99661-KIF2C_HUMAN
    Recommended name:
    Kinesin-like protein KIF2C
    Protein Accession:
    Q99661
    Secondary Accessions:
    • B3ITR9
    • Q5JR88
    • Q6ICU1
    • Q96C18
    • Q96HB8
    • Q9BWV8

    Protein attributes for KIF2C Gene

    Size:
    725 amino acids
    Molecular mass:
    81313 Da
    Quaternary structure:
    • Interacts with CENPH. Interacts with MTUS2/TIP150; the interaction is direct. Interacts with MAPRE1; the interaction is direct, regulated by phosphorylation and is probably required for targeting to growing microtubule plus ends. Interacts with KIF18B at microtubule tips; this interaction increases the affinity of both partners for microtubule plus ends and is required for robust microtubule depolymerization. Phosphorylation by AURKA or AURKB strongly reduces KIF18B-binding.

    Three dimensional structures from OCA and Proteopedia for KIF2C Gene

    Alternative splice isoforms for KIF2C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF2C Gene

Proteomics data for KIF2C Gene at MOPED

Post-translational modifications for KIF2C Gene

  • Phosphorylation by AURKB, regulates association with centromeres and kinetochores and the microtubule depolymerization activity.
  • Ubiquitinated.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys38, Lys365, Lys487, and Lys518

Other Protein References for KIF2C Gene

No data available for DME Specific Peptides for KIF2C Gene

Domains for KIF2C Gene

Gene Families for KIF2C Gene

HGNC:
  • KIF :Kinesins

Protein Domains for KIF2C Gene

UniProtKB/Swiss-Prot:

KIF2C_HUMAN
Domain:
  • The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends.:
    • Q99661
  • Contains 1 kinesin motor domain.:
    • Q99661
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.:
    • Q99661
genes like me logo Genes that share domains with KIF2C: view

Function for KIF2C Gene

Molecular function for KIF2C Gene

UniProtKB/Swiss-Prot Function: In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis.

Gene Ontology (GO) - Molecular Function for KIF2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity IBA --
GO:0005515 protein binding IPI 11092768
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding --
GO:0016887 ATPase activity IBA --
genes like me logo Genes that share ontologies with KIF2C: view

Phenotypes for KIF2C Gene

GenomeRNAi human phenotypes for KIF2C:
genes like me logo Genes that share phenotypes with KIF2C: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KIF2C Gene

Localization for KIF2C Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF2C Gene

Cytoplasm, cytoskeleton. Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Associates with the microtubule network at the growing distal tip (the plus-end) of microtubules, probably through interaction with MTUS2/TIP150 and MAPRE1 (By similarity). Association with microtubule plus ends is also mediated by interaction with KIF18B. Centromeric localization requires the presence of BUB1 and SGOL2. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIF2C Gene COMPARTMENTS Subcellular localization image for KIF2C gene
Compartment Confidence
cytoskeleton 4
cytosol 4
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for KIF2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IDA 14960279
GO:0000776 colocalizes_with kinetochore IDA 14960279
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with KIF2C: view

Pathways for KIF2C Gene

genes like me logo Genes that share pathways with KIF2C: view

Pathways by source for KIF2C Gene

1 Qiagen pathway for KIF2C Gene
2 BioSystems pathways for KIF2C Gene

Gene Ontology (GO) - Biological Process for KIF2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0006200 obsolete ATP catabolic process --
GO:0007018 microtubule-based movement TAS --
GO:0007019 microtubule depolymerization IMP 19060894
GO:0007059 chromosome segregation --
genes like me logo Genes that share ontologies with KIF2C: view

Compounds for KIF2C Gene

(2) Drugbank Compounds for KIF2C Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Adenosine-5'-Diphosphate
20398-34-9 target
Phosphoaminophosphonic Acid-Adenylate Ester
target

(2) Novoseek inferred chemical compound relationships for KIF2C Gene

Compound -log(P) Hits PubMed IDs
pravastatin 41.1 1
atp 14.2 3
genes like me logo Genes that share compounds with KIF2C: view

Transcripts for KIF2C Gene

Unigene Clusters for KIF2C Gene

Kinesin family member 2C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIF2C Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a ·
SP1: - - - - -
SP2: - -
SP3:
SP4:
SP5: - -

ExUns: 21b ^ 22a · 22b
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for KIF2C Gene

GeneLoc Exon Structure for
KIF2C
ECgene alternative splicing isoforms for
KIF2C

Expression for KIF2C Gene

mRNA expression in normal human tissues for KIF2C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIF2C Gene

This gene is overexpressed in Testis (21.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIF2C Gene

SOURCE GeneReport for Unigene cluster for KIF2C Gene Hs.720061

mRNA Expression by UniProt/SwissProt for KIF2C Gene

Q99661-KIF2C_HUMAN
Tissue specificity: Expressed at high levels in thymus and testis, at low levels in small intestine, the mucosal lining of colon, and placenta, and at very low levels in spleen and ovary; expression is not detected in prostate, peripheral blood Leukocytes, heart, brain, lung, liver, skeletal muscle, kidney or pancreas. Isoform 2 is testis-specific.
genes like me logo Genes that share expressions with KIF2C: view

Orthologs for KIF2C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KIF2C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF2C 36
  • 99.68 (n)
  • 99.45 (a)
KIF2C 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIF2C 36
  • 91.24 (n)
  • 91.29 (a)
KIF2C 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIF2C 36
  • 91.56 (n)
  • 91.98 (a)
KIF2C 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kif2c 36
  • 87.2 (n)
  • 88.55 (a)
Kif2c 16
Kif2c 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIF2C 37
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF2C 37
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kif2c 36
  • 86.5 (n)
  • 88.41 (a)
chicken
(Gallus gallus)
Aves KIF2C 37
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIF2C 37
  • 67 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia kif2c-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia kif2c 36
  • 66 (n)
  • 67.66 (a)
Str.4037 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5588 36
zebrafish
(Danio rerio)
Actinopterygii Dr.13963 36
kif2c 37
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Klp10A 37
  • 41 (a)
ManyToMany
Klp59C 37
  • 46 (a)
ManyToMany
Klp59D 37
  • 40 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea klp-7 36
  • 52.53 (n)
  • 50.27 (a)
klp-7 37
  • 40 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3329 36
corn
(Zea mays)
Liliopsida Zm.7332 36
wheat
(Triticum aestivum)
Liliopsida Ta.4571 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 47 (a)
OneToMany
Species with no ortholog for KIF2C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for KIF2C Gene

ENSEMBL:
Gene Tree for KIF2C (if available)
TreeFam:
Gene Tree for KIF2C (if available)

Paralogs for KIF2C Gene

Paralogs for KIF2C Gene

Pseudogenes.org Pseudogenes for KIF2C Gene

genes like me logo Genes that share paralogs with KIF2C: view

Variants for KIF2C Gene

Sequence variations from dbSNP and Humsavar for KIF2C Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1140279 -- 44,760,412(+) GGCGC(A/G)GACAC synonymous-codon, reference
rs1804673 -- 44,762,563(+) AGGAG(G/T)AACTG reference, stop-gained
rs3795712 -- 44,740,823(+) TTCAG(A/G)TTAAC intron-variant
rs3795713 -- 44,753,223(+) ATCCG(A/T)GGCAG intron-variant, reference, synonymous-codon
rs3795714 -- 44,758,335(+) GTATG(G/T)CAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF2C Gene

Variant ID Type Subtype PubMed ID
nsv461406 CNV Loss 19166990

Relevant External Links for KIF2C Gene

HapMap Linkage Disequilibrium report
KIF2C

Disorders for KIF2C Gene

(1) Novoseek inferred disease relationships for KIF2C Gene

Disease -log(P) Hits PubMed IDs
myocardial infarction 0 1

Relevant External Links for KIF2C

Genetic Association Database (GAD)
KIF2C
Human Genome Epidemiology (HuGE) Navigator
KIF2C
genes like me logo Genes that share disorders with KIF2C: view

No data available for UniProtKB/Swiss-Prot for KIF2C Gene

Publications for KIF2C Gene

  1. Cloning and expression of human mitotic centromere-associated kinesin gene. (PMID: 9434124) Kim I.-G. … Kim Y.H. (Biochim. Biophys. Acta 1997) 2 3 4 23
  2. Aurora B regulates MCAK at the mitotic centromere. (PMID: 14960279) Andrews P.D. … Swedlow J.R. (Dev. Cell 2004) 3 4 23
  3. Genome stability is ensured by temporal control of kinetochore- microtubule dynamics. (PMID: 19060894) Bakhoum S.F. … Compton D.A. (Nat. Cell Biol. 2009) 3 4 23
  4. TIP150 interacts with and targets MCAK at the microtubule plus ends. (PMID: 19543227) Jiang K. … Yao X. (EMBO Rep. 2009) 3 4 23
  5. Functional and spatial regulation of mitotic centromere-associated kinesin by cyclin-dependent kinase 1. (PMID: 20368358) Sanhaji M. … Yuan J. (Mol. Cell. Biol. 2010) 3 23

Products for KIF2C Gene

  • Addgene plasmids for KIF2C

Sources for KIF2C Gene

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