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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KIF2C Gene

protein-coding   GIFtS: 59
GCID: GC01P045208

kinesin family member 2C

(Previous name: kinesin-like 6 (mitotic centromere-associated kinesin)...)
(Previous symbol: KNSL6)
 Explore 13 diseases affiliated with
KIF2C via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KIF2C    

Aliases
for KIF2C gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Kinesin Family Member 2C1 2     Mitotic Centromere-Associated Kinesin2 3
KNSL61 2 3 5     Kinesin-Like 6 (Mitotic Centromere-Associated Kinesin)1
MCAK1 2 3 5     Kinesin-Like 62
Kinesin-Like Protein 62 3     Kinesin-Like Protein KIF2C2

External Ids:    HGNC: 63931   Entrez Gene: 110042   Ensembl: ENSG000001429457   OMIM: 6045385   UniProtKB: Q996613   

Export aliases for KIF2C gene to outside databases

Previous GC identifers: GC01P044205 GC01P044635 GC01P044618 GC01P044874 GC01P044978 GC01P043319


Summaries
for KIF2C gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KIF2C:
The protein encoded by this gene is a member of kinesin-like protein family. Proteins of this family are
microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell
division. This protein is important for anaphase chromosome segregation and may be required to coordinate the onset of
sister centromere separation. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KIF2C_HUMAN, Q99661
Function: In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells.
Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis

Gene Wiki entry for KIF2C


Genomic Views
for KIF2C gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KIF2C gene promoter:
         TBP   ER-alpha   Spz1   AML1a   ATF-2   C/EBPalpha   Egr-4   YY1   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KIF2C promoter sequence
   Search SABiosciences Chromatin IP Primers for KIF2C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIF2C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.1   Ensembl cytogenetic band:  1p34.1   HGNC cytogenetic band: 1p34.1

KIF2C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIF2C gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P045208:  view genomic region     (about GC identifiers)

Start:
 45,205,490 bp from pter      End:
 45,233,439 bp from pter
Size:
 27,950 bases      Orientation:
 plus strand

Proteins
for KIF2C gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KIF2C_HUMAN, Q99661 (See protein sequence)
Recommended Name: Kinesin-like protein KIF2C  
Size: 725 amino acids; 81313 Da
Subunit: Interacts with CENPH. Interacts with MTUS2/TIP150; the interaction is direct. Interacts with MAPRE1; the
interaction is direct, regulated by phosphorylation and is probably required for targeting to growing microtubule plus
ends. Interacts with KIF18B at microtubule tips; this interaction increases the affinity of both partners for
microtubule plus ends and is required for robust microtubule depolymerization. Phosphorylation by AURKA or AURKB
strongly reduces KIF18B-binding
Subcellular location: Cytoplasm, cytoskeleton (By similarity). Nucleus (By similarity). Chromosome, centromere.
Chromosome, centromere, kinetochore. Note=Associates with the microtubule network at the growing distal tip (the
plus-end) of microtubules, probably through interaction with MTUS2/TIP150 and MAPRE1 (By similarity). Association with
microtubule plus ends is also mediated by interaction with KIF18B. Centromeric localization requires the presence of
BUB1 and SGOL2
Developmental stage: Isoform 2 is expressed in fetal testis
1 PDB 3D structure from and Proteopedia for KIF2C:
2HEH (3D)    
Secondary accessions: B3ITR9 Q5JR88 Q6ICU1 Q96C18 Q96HB8 Q9BWV8
Alternative splicing: 2 isoforms:  Q99661-1   Q99661-2   

Explore the universe of human proteins at neXtProt for KIF2C: NX_Q99661

Post-translational modifications:

  • Phosphorylation by AURKB, regulates association with centromeres and kinetochores and the microtubule depolymerization
    • activity1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q99661

    • KIF2C Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006836.2  
    ENSEMBL proteins: 
     ENSP00000410346   ENSP00000361298   ENSP00000395050   ENSP00000361291   ENSP00000402172  
     ENSP00000361292   ENSP00000361296  
    Reactome Protein details: Q99661
    Human Recombinant Protein Products: 
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    Uscn Proteins for KIF2C

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region IDA14960279
    GO:0000776colocalizes with kinetochore IDA14960279
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--


    KIF2C for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for KIF2C

    Protein Domains /
    Families
    for KIF2C gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KIF2C for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001752 Kinesin_motor_dom
     IPR019821 Kinesin_motor_CS

    Graphical View of Domain Structure for InterPro Entry Q99661

    ProtoNet protein and cluster: Q99661

    1 Blocks protein family: IPB001752 Kinesin

    UniProtKB/Swiss-Prot: KIF2C_HUMAN, Q99661
    Domain: The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the
    growing microtubule plus ends
    Similarity: Belongs to the kinesin-like protein family. MCAK/KIF2 subfamily
    Similarity: Contains 1 kinesin-motor domain


    Function
    for KIF2C gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KIF2C_HUMAN, Q99661
    Function: In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells.
    Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003777microtubule motor activity IEA--
    GO:0005515protein binding IPI19632184
    GO:0005524ATP binding IEA--
    GO:0019237centromeric DNA binding TAS9434124
    GO:0051010microtubule plus-end binding IDA19632184


    KIF2C for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for KIF2C:
     Synthetic lethal with Ras 


    Pathways & Interactions
    for KIF2C gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1M Phase
    		M Phase1.00
    		Mitotic Anaphase0.85
    		Mitotic M-M/G1 phases0.88
    		Separation of Sister Chromatids0.80
    		Mitotic Metaphase and Anaphase0.85
    2Resolution of Sister Chromatid Cohesion
    		Resolution of Sister Chromatid Cohesion1.00
    		Mitotic Prometaphase0.93
    		Kinetochore assembly0.96
    3Immune System
    		Immune System1.00
    		Adaptive Immune System0.59
    4Kinesins
    		Kinesins1.00
    		Kinesins move along microtubules consuming ATP0.95
    5Cell Cycle
    		Cell Cycle1.00
    		Cell Cycle, Mitotic0.84

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for KIF2C 
        Aurora B signaling

    5/18        Reactome Pathways for KIF2C (see all 18)
        Mitotic Prometaphase
    Resolution of Sister Chromatid Cohesion
    Cell Cycle
    M Phase
    Transport of antigen loaded MHC II molecules to surface



    KIF2C for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIF2C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/819 Interacting proteins for KIF2C (Q996612, 3 ENSP000003612984) via UniProtKB, MINT, STRING, and/or I2D (see all 819)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MTUS2Q5JR592, 3MINT-7256299 MINT-7256258 MINT-7256235 MINT-7256361 MINT-7256216 MINT-7256202 I2D: score=1 
    MAPRE1Q156912, 3, ENSP000003647214MINT-7256299 MINT-7256258 MINT-7256324 MINT-7256284 I2D: score=2 STRING: ENSP00000364721
    CSNK2BP678702, 3MINT-8253363 I2D: score=2 
    SQSTM1Q135012, 3MINT-7945693 I2D: score=1 
    AURKBQ96GD42, ENSP000003139504MINT-7945693 MINT-7947479 STRING: ENSP00000313950
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000087M phase of mitotic cell cycle TAS--
    GO:0000236mitotic prometaphase TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0007018microtubule-based movement TAS--
    GO:0007019microtubule depolymerization IMP19060894


    KIF2C for ontologies           About GeneDecksing



    Drugs & Compounds
    for KIF2C gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KIF2C for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for KIF2C

    2 DrugBank Compounds for KIF2C    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine-5'-Diphosphate-- 20398-34-9target--17139284 17016423 10592235
    Phosphoaminophosphonic Acid-Adenylate Ester-- --target--17139284 17016423 10592235

    2 Novoseek chemical compound relationships for KIF2C gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pravastatin 41.1 1 18222355 (1)
    atp 14.2 3 15304328 (3)

    Search CenterWatch for drugs/clinical trials and news about KIF2C 

    Transcripts
    for KIF2C gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KIF2C gene: 
    NM_006845.3  

    Unigene Cluster for KIF2C:

    Kinesin family member 2C
    Hs.720061  [show with all ESTs]
    Unigene Representative Sequence: NM_006845
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000452259 ENST00000372224(uc001cmg.4 uc010olb.2) ENST00000493027
    ENST00000455186 ENST00000372217(uc010olc.2 uc001cmh.4) ENST00000480574
    ENST00000423289 ENST00000472235 ENST00000372218 ENST00000372222

    miRNA
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    hsa-miR-2355-5p hsa-miR-186* hsa-miR-3915
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    Inhib. RNA
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    Additional cDNA sequence: 

    AB264115.1 AK124208.1 AK290688.1 AK300756.1 AK302267.1 AK312606.1 AY026505.1 BC008764.2 
    BC014924.1 BC032038.1 BT006759.1 CR450302.1 U63743.1 

    24 DOTS entries:

    DT.95108533  DT.214347  DT.95205289  DT.121388380  DT.92443637  DT.95205295  DT.100813666  DT.100813662 
    DT.100039576  DT.100813659  DT.101968187  DT.95205179  DT.102823576  DT.121388191  DT.121388323  DT.100813660 
    DT.121388227  DT.121388264  DT.121388456  DT.40131564  DT.95304859  DT.40242026  DT.95205180  DT.97815359 

    24/268 AceView cDNA sequences (see all 268):

    BC014924 AU132090 BQ061928 AU130795 AI798169 BU186303 BM473109 BM548767 
    AA393163 BC032038 BI831051 BM753248 BX280650 BU527428 BP365214 AA524247 
    CA454677 AA622869 CA416354 AU132361 BP368055 CA453930 AU132752 AI608727 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for KIF2C    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a ·
    SP1:                    -     -     -                 -                                                                                   -                     
    SP2:                                                  -                                                                                   -                     
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                    -     -                                                                                                                                 

    ExUns: 21b ^ 22a · 22b
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for KIF2C

    Expression
    for KIF2C gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KIF2C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGACACTCCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KIF2C expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Neural TubeNeural TubeSpinal Neural Tube CellsNeural Ectoderm
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)
    PureStem™ progenitor F15 (Embryonic Progenitor Cell)
    Adult human kidney epithelial cells (Primary Cell)Kidney

    See KIF2C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KIF2C

    SOURCE GeneReport for Unigene cluster: Hs.720061

    UniProtKB/Swiss-Prot: KIF2C_HUMAN, Q99661
    Tissue specificity: Expressed at high levels in thymus and testis, at low levels in small intestine, the mucosal lining
    of colon, and placenta, and at very low levels in spleen and ovary; expression is not detected in prostate, peripheral
    blood Leukocytes, heart, brain, lung, liver, skeletal muscle, kidney or pancreas. Isoform 2 is testis-specific

        SABiosciences Expression via Pathway-Focused PCR Array including KIF2C: 
              T Helper Cell Differentiation in human mouse rat

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    Orthologs
    for KIF2C gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for KIF2C gene from 8/27 species (see all 27)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves KIF2C1 kinesin family member 2C 68.49(n)
    69.8(a)    		   424583  XM_422422.3  XP_422422.2 
    lizard
    (Anolis carolinensis)    		 Reptilia KIF2C6
    		 --
    		 63(a)
    		 1 ↔ 1
    		 4(110045461-110076130)
    African clawed frog
    (Xenopus laevis)    		 Amphibia kif2c-prov2 kinesin family member 2C 76.19(n)    BC044976.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.139632 Transcribed sequence with moderate similarity to protein more 76.76(n)    57046148 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Klp59C6
    Klp10A6
    (see all 3)    		 Klp10A
    (see all 3)    		 43(a)
    40(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 2R(19011517-19013565)
    X(11023395-11031056)
    worm
    (Caenorhabditis elegans)    		 Secernentea klp-76
    		 Kinesin-Like Protein family member (klp-7)
    		 36(a)
    		 1 → many
    		 III(10805831-10810902)
    Alicante grape
    (Vitis vinifera)    		 eudicotyledons Vvi.33292 Vitis vinifera transcribed sequence with moderate similarity more 79.01(n)    CF215404.1 
    rice
    (Oryza sativa)    		 Liliopsida NM_185267.12   -- 79.42(n)    NM_185267.1 


    ENSEMBL Gene Tree for KIF2C (if available)
    TreeFam Gene Tree for KIF2C (if available) 

    Paralogs
    for KIF2C gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KIF2C gene
    KIF2A2  KIF2B2  KIF242  
    17 SIMAP similar genes for KIF2C using alignment to 6 protein entries:     KIF2C_HUMAN (see all proteins):
    KIF24    KIF21A    KLP6    KIF2A    KIF2B    KIF18B
    KIFC3    STARD9    KIF1A    KIF13A    KIF13B    KIF6
    KIF27    KIF5C    KIF3A    KIF5A    KIF5B

    KIF2C for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for KIF2C
    PGOHUM00000244754


    Genomic Variants
    for KIF2C gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/510 NCBI SNPs in KIF2C are shown (see all 510)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1121036531,2
    		C,--45203586(+) GAGGCG/CGGGCT 1 -- us2k11Minor allele frequency- C:0.50NA 2
    rs597887231,2
    		--45203672(+) CAGCCC/TGGGCA 1 -- us2k10--------
    rs1899669491,2
    		--45203784(+) GTACTC/GCCGCC 1 -- us2k10--------
    rs1121089771,2
    		--45203859(+) GCAGGT/CGCGCG 1 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs1866283881,2
    		--45203867(+) GCGCCA/GCCGCA 1 -- us2k10--------
    rs617899381,2
    		--45203955(+) GAGTGG/ATCTGC 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1910371751,2
    		--45204276(+) GGATCA/GTCTCT 1 -- us2k10--------
    rs1839303441,2
    		--45204290(+) TGGCCA/GCCCCG 1 -- us2k10--------
    rs593665491,2
    		C,--45204339(+) CGTCCG/AGGAGA 1 -- us2k14Minor allele frequency- A:0.31NA WA EA 360
    rs1884359571,2
    		--45204362(+) CCTCCC/TGGCAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KIF2C (45205490 - 45233439 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for KIF2C: --

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    Disorders / Diseases
    for KIF2C gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KIF2C for disorders           About GeneDecksing

    OMIM gene information: 604538    OMIM disorders: --

    13 diseases for KIF2C:    About MalaCards
    adenomatous polyposis coli    myocardial infarction    acute myocardial infarction    coronary heart disease
    polyposis    gout    gastric cancer    colorectal cancer
    breast cancer    melanoma    malaria    prostatitis
    coronary heart disease 2

    1 Novoseek disease relationship for KIF2C gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myocardial infarction 0 1 18222353 (1)

    Human Genome Epidemiology (HuGE) Navigator: KIF2C (1 document)

    Export disorders for KIF2C gene to outside databases

    Publications
    for KIF2C gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KIF2C gene, integrated from 9 sources (see all 95):
    (articles sorted by number of sources associating them with KIF2C)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of human mitotic centromere-associated kinesin gene. (PubMed id 9434124)1, 2, 3, 9 Kim I.-G.... Kim Y.H. (1997)
    2. Aurora B regulates MCAK at the mitotic centromere. (PubMed id 14960279)1, 2, 9 Andrews P.D....Swedlow J.R. (2004)
    3. TIP150 interacts with and targets MCAK at the microtubule plus ends. (PubMed id 19543227)1, 2, 9 Jiang K....Yao X. (2009)
    4. Genome stability is ensured by temporal control of kinetochore-microtubule dynamics. (PubMed id 19060894)1, 2, 9 Bakhoum S.F....Compton D.A. (2009)
    5. A complex of Kif18b and MCAK promotes microtubule dep olymerization and is negatively regulated by Aurora kinases. (PubMed id 21820309)1, 2 Tanenbaum M.E....Medema R.H. (2011)
    6. An EB1-binding motif acts as a microtubule tip locali zation signal. (PubMed id 19632184)1, 2 Honnappa S....Steinmetz M.O. (2009)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Expression of a novel HsMCAK mRNA splice variant, tsMCAK gene, in human testis. (PubMed id 12383881)1, 2 Cheng L.J.... Sha J.H. (2002)
    9. Human CENP-H multimers colocalize with CENP-A and CENP-C at active centromere-kinetochore complexes. (PubMed id 11092768)1, 2 Sugata N.... Todokoro K. (2000)
    10. Clinicopathological and biological significance of mitotic centromere-associated kinesin overexpression in human gastric cancer. (PubMed id 17653072)1, 9 Nakamura Y....Mori M. (2007)

    External Searches for KIF2C gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing KIF2C gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11004 HGNC: 6393 AceView: KIF2C Ensembl:ENSG00000142945 euGenes: HUgn11004
    ECgene: KIF2C H-InvDB: KIF2C

    Other Databases showing KIF2C gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KIF2C gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KIF2C Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KIF2C Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for KIF2C gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KIF2C gene:
    Search GeneIP for patents involving KIF2C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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