KIF2B Gene
protein-coding GIFtS: 48
GCID: GC17P051900
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kinesin family member 2B
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Aliases
for KIF2B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Kinesin Family Member 2B1 2 | | Kinesin Protein2 | | Kinesin-Like Protein KIF2B2 |
Export aliases for KIF2B gene to outside databasesPrevious GC identifers: GC17P049256 GC17P047268 |
Summaries
for KIF2B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: KIF2B_HUMAN, Q8N4N8Function: Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Hasmicrotubule depolymerization activity
|
Genomic Views
for KIF2B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KIF2B gene promoter:
AhR STAT1 STAT1beta CUTL1 GATA-1 ATF6 STAT1alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for KIF2B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIF2B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q22 Ensembl cytogenetic band: 17q22 HGNC cytogenetic band: 17q22KIF2B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P051900: view genomic region
(about GC identifiers)
Start:
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51,900,239 bp from pter |
End:
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51,902,573 bp from pter |
Size:
|
2,335 bases |
Orientation:
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plus strand |
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Proteins
for KIF2B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KIF2B_HUMAN, Q8N4N8 (See
protein sequence)Recommended Name: Kinesin-like protein KIF2B Size: 673 amino acids; 76254 Da
Subcellular location: Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere,kinetochore. Note=Association with kinetochore is transient
Miscellaneous: Osteosarcoma cells (U2OS) lacking KIF2B show disorganised often monopolar mitotic spindles, severelyreduced velocity of chromosome movement and blocked cytokinesis. Bipolar mitotic spindles can be restored bysimultaneous depletion of KIF2B, KIFC1 and NUMA1
Secondary accessions: Q96MA2 Q9BXG6Explore the universe of human proteins at neXtProt for KIF2B: NX_Q8N4N8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N4N8
KIF2B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115948.4
ENSEMBL proteins: ENSP00000268919 Reactome Protein details: Q8N4N8
Human Recombinant Protein Products for KIF2B:
Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table
KIF2B for ontologies About GeneDecksing
KIF2B Antibody Products:
Assay Products for KIF2B: |
Protein
Domains /
Families
for KIF2B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KIF2B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N4N8ProtoNet protein and cluster: Q8N4N8 1 Blocks protein family: IPB001752 Kinesin
UniProtKB/Swiss-Prot: KIF2B_HUMAN, Q8N4N8Similarity: Belongs to the kinesin-like protein family. MCAK/KIF2 subfamilySimilarity: Contains 1 kinesin-motor domain |
Function
for KIF2B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: KIF2B_HUMAN, Q8N4N8Function: Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Hasmicrotubule depolymerization activity Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003777 | microtubule motor activity |
IEA | -- | | GO:0005524 | ATP binding |
IEA | -- |
KIF2B for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIF2B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIF2B
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: KIF2B (NM_032559) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KIF2B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIF2B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF2B |
|
Pathways & Interactions
for KIF2B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | M Phase | | | 2 | Resolution of Sister Chromatid Cohesion | | | 3 | Immune System | | | 4 | Kinesins | | | 5 | Cell Cycle | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/18 
Reactome Pathways for KIF2B (see all 18)
KIF2B for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIF2B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/70 Interacting proteins for KIF2B (Q8N4N83 ENSP000002689194) via UniProtKB, MINT, STRING, and/or I2D (see all 70)About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table
KIF2B for ontologies About GeneDecksing
|
Drugs & Compounds
for KIF2B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
KIF2B for compounds About GeneDecksing
 Browse Tocris compounds for KIF2B
2 Novoseek chemical compound relationships for KIF2B gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| adp |
9.42 |
1 |
7635215 (1) |
| nmda |
0.193 |
1 |
12514209 (1) |
Search CenterWatch for drugs/clinical trials and news about KIF2B
|
Transcripts
for KIF2B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KIF2B gene: NM_032559.4 Unigene Clusters for KIF2B: Kinesin family member 2B Hs.743937 , Hs.744513 [show with all ESTs]Unigene Representative Sequences: AK302262, AF3333351 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000268919(uc002iua.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIF2B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIF2B
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KIF2B (NM_032559) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KIF2B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIF2B |
Additional cDNA sequence: AF333335.2 AK057272.1 AK308265.1 BC033802.1 2 DOTS entries: DT.92062227 DT.100741635 24/31 AceView cDNA sequences (see all 31): BI829106 NM_032559 CD634111 BG771992 AF333335 BM560261 CD634109 CD634112 CD171892 BP371589 CD244601 BP371564 AK057272 CD634117 BI461290 BI463904 CD299965 BC033802 BG721597 CD634115 BI561657 BI462901 AI394377 AI962748
GeneLoc Exon Structure
|
Expression
for KIF2B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KIF2B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCTTTCTTC
About this image
See KIF2B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KIF2B
SOURCE GeneReport for Unigene clusters: Hs.743937 Hs.744513
UniProtKB/Swiss-Prot: KIF2B_HUMAN, Q8N4N8Tissue specificity: Highest level in lung. High level in ovary, moderate levels in heart, kidney, placenta, skeletalmuscle and spleen (at protein level). Pancreas and spleen express a shorter isoform (at protein level)
SABiosciences Custom PCR Arrays for KIF2B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIF2B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KIF2B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIF2B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIF2B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF2B |
Orthologs
for KIF2B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for KIF2B gene from 4/19 species (see all 19) About this table
ENSEMBL Gene Tree for KIF2B (if available)
TreeFam Gene Tree for KIF2B (if available) |
Paralogs
for KIF2B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KIF2B gene
- KIF2A2 KIF242 KIF2C2
3 SIMAP similar genes for KIF2B using alignment to 1 protein entry: KIF2B_HUMAN:KIF2A KIF24 KIF2C
KIF2B for paralogs About GeneDecksing
|
Genomic Variants
for KIF2B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KIF2B (51900239 - 51902573 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KIF2B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIF2B |
|
Disorders
/ Diseases
for KIF2B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KIF2B for disorders About GeneDecksing
12  diseases for KIF2B: About MalaCardscharcot-marie-tooth disease charcot-marie-tooth disease type 4 tooth disease hereditary neuropathies
neuropathy leishmaniasis osteosarcoma obesity
hypertension neuroblastoma malaria neuronitis
Human Genome Epidemiology (HuGE) Navigator: KIF2B (1 document)
Export disorders for KIF2B gene to outside databases
|
Publications
for KIF2B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KIF2B gene, integrated from 9 sources (see all 63):
(articles sorted by number of sources associating them with KIF2B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- All kinesin superfamily protein, KIF, genes in mouse and human. (PubMed id 11416179)1, 3, 9 Miki H....Hirokawa N. (2001)
- The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells. (PubMed id 17538014)1, 2 Manning A.L....Compton D.A. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Plk1 regulates the kinesin-13 protein Kif2b to promote faithful chromosome segregation. (PubMed id 22535524)1 Hood E.A....Compton D.A. (2012)
- A genome-wide study reveals copy number variants excl usive to childhood obesity cases. (PubMed id 20950786)1 Glessner J.T....Grant S.F. (2010)
- CLASP1, astrin and Kif2b form a molecular switch that regulates kinetochore-microtubule dynamics to promote mitotic progression and fidelity. (PubMed id 20852589)1 Manning A.L....Compton D.A. (2010)
- Genome stability is ensured by temporal control of kinetochore-microtubule dynamics. (PubMed id 19060894)1 Bakhoum S.F....Compton D.A. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
|
External Searches for KIF2B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KIF2B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KIF2B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KIF2B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KIF2B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KIF2B gene:
Search GeneIP for patents involving KIF2B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KIF2B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KIF2B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KIF2B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIF2B | | | OriGene Protein Over-expression Lysate for KIF2B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KIF2B | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIF2B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIF2B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KIF2B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIF2B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIF2B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIF2B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIF2B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIF2B |
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 | | | KIF2B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF2B |
|  |  |  |  | | | | Search ThermoFisher Antibodies for KIF2B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIF2B |
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