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Aliases for KIF2B Gene

Aliases for KIF2B Gene

  • Kinesin Family Member 2B 2 3

External Ids for KIF2B Gene

Summaries for KIF2B Gene

GeneCards Summary for KIF2B Gene

KIF2B (Kinesin Family Member 2B) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Cell Cycle, Mitotic. GO annotations related to this gene include microtubule binding and microtubule motor activity. An important paralog of this gene is KIF2A.

UniProtKB/Swiss-Prot for KIF2B Gene

  • Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF2B Gene

Genomics for KIF2B Gene

Genomic Location for KIF2B Gene

Start:
53,822,878 bp from pter
End:
53,825,213 bp from pter
Size:
2,336 bases
Orientation:
Plus strand

Genomic View for KIF2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIF2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF2B Gene

Regulatory Elements for KIF2B Gene

Proteins for KIF2B Gene

  • Protein details for KIF2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4N8-KIF2B_HUMAN
    Recommended name:
    Kinesin-like protein KIF2B
    Protein Accession:
    Q8N4N8
    Secondary Accessions:
    • Q96MA2
    • Q9BXG6

    Protein attributes for KIF2B Gene

    Size:
    673 amino acids
    Molecular mass:
    76254 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Osteosarcoma cells (U2OS) lacking KIF2B show disorganised often monopolar mitotic spindles, severely reduced velocity of chromosome movement and blocked cytokinesis. Bipolar mitotic spindles can be restored by simultaneous depletion of KIF2B, KIFC1 and NUMA1

neXtProt entry for KIF2B Gene

Proteomics data for KIF2B Gene at MOPED

Post-translational modifications for KIF2B Gene

  • Phosphorylation at Thr-125 by PLK1 is required for activity in the correction of kinetochore-microtubules attachment errors, while phosphorylation at Ser-204 also by PLK1 is required for the kinetochore localization and activity in prometaphase.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys442

Other Protein References for KIF2B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KIF2B Gene

Domains for KIF2B Gene

Gene Families for KIF2B Gene

HGNC:
  • KIF :Kinesins

Protein Domains for KIF2B Gene

UniProtKB/Swiss-Prot:

KIF2B_HUMAN
Domain:
  • Contains 1 kinesin motor domain.:
    • Q8N4N8
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.:
    • Q8N4N8
genes like me logo Genes that share domains with KIF2B: view

Function for KIF2B Gene

Molecular function for KIF2B Gene

UniProtKB/Swiss-Prot Function: Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity.

Gene Ontology (GO) - Molecular Function for KIF2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity IBA --
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
GO:0016887 ATPase activity IBA --
genes like me logo Genes that share ontologies with KIF2B: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KIF2B Gene

Localization for KIF2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF2B Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Association with kinetochore is transient.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIF2B Gene COMPARTMENTS Subcellular localization image for KIF2B gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 4
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KIF2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with KIF2B: view

Pathways for KIF2B Gene

genes like me logo Genes that share pathways with KIF2B: view

Pathways by source for KIF2B Gene

Gene Ontology (GO) - Biological Process for KIF2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0006200 obsolete ATP catabolic process --
GO:0007018 microtubule-based movement TAS --
GO:0007019 microtubule depolymerization IMP 19060894
GO:0007067 mitotic nuclear division IEA --
genes like me logo Genes that share ontologies with KIF2B: view

Compounds for KIF2B Gene

(2) Novoseek inferred chemical compound relationships for KIF2B Gene

Compound -log(P) Hits PubMed IDs
adp 9.42 1
nmda 0.193 1
genes like me logo Genes that share compounds with KIF2B: view

Transcripts for KIF2B Gene

mRNA/cDNA for KIF2B Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(31) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KIF2B Gene

Kinesin family member 2B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIF2B Gene

No ASD Table

Relevant External Links for KIF2B Gene

GeneLoc Exon Structure for
KIF2B
ECgene alternative splicing isoforms for
KIF2B

Expression for KIF2B Gene

mRNA expression in normal human tissues for KIF2B Gene

mRNA differential expression in normal tissues according to GTEx for KIF2B Gene

This gene is overexpressed in Testis (52.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIF2B Gene

SOURCE GeneReport for Unigene cluster for KIF2B Gene Hs.226805

mRNA Expression by UniProt/SwissProt for KIF2B Gene

Q8N4N8-KIF2B_HUMAN
Tissue specificity: Highest level in lung. High level in ovary, moderate levels in heart, kidney, placenta, skeletal muscle and spleen (at protein level). Pancreas and spleen express a shorter isoform (at protein level).
genes like me logo Genes that share expressions with KIF2B: view

Orthologs for KIF2B Gene

This gene was present in the common ancestor of animals.

Orthologs for KIF2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF2B 36
  • 99.11 (n)
  • 98.66 (a)
KIF2B 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIF2B 36
  • 80.7 (n)
  • 73.43 (a)
KIF2B 37
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIF2B 36
  • 85.53 (n)
  • 79.79 (a)
KIF2B 37
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kif2b 36
  • 79.59 (n)
  • 78.59 (a)
Kif2b 16
Kif2b 37
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIF2B 37
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF2B 37
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kif2b 36
  • 79.97 (n)
  • 78.92 (a)
chicken
(Gallus gallus)
Aves KIF2B 37
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIF2B 37
  • 50 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CABZ01117349.1 37
  • 41 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Klp10A 37
  • 36 (a)
ManyToMany
Klp59C 37
  • 41 (a)
ManyToMany
Klp59D 37
  • 36 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea klp-7 37
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 43 (a)
OneToMany
Species with no ortholog for KIF2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KIF2B Gene

ENSEMBL:
Gene Tree for KIF2B (if available)
TreeFam:
Gene Tree for KIF2B (if available)

Paralogs for KIF2B Gene

Paralogs for KIF2B Gene

Selected SIMAP similar genes for KIF2B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KIF2B: view

Variants for KIF2B Gene

Sequence variations from dbSNP and Humsavar for KIF2B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs768243 -- 53,820,931(+) AAAAA(A/T)GTCCT upstream-variant-2KB
rs2331877 -- 53,821,077(+) AAAAC(A/C)CTATG upstream-variant-2KB
rs3803824 - 53,823,368(+) TACCG(C/T)CACGA reference, missense
rs3803825 -- 53,823,723(+) ACCTT(A/G)AAGGA reference, synonymous-codon
rs3803826 -- 53,824,024(+) ATGCT(C/T)TGGTG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for KIF2B Gene

Variant ID Type Subtype PubMed ID
nsv908620 CNV Loss 21882294

Relevant External Links for KIF2B Gene

HapMap Linkage Disequilibrium report
KIF2B
Human Gene Mutation Database (HGMD)
KIF2B

Disorders for KIF2B Gene

Relevant External Links for KIF2B

Genetic Association Database (GAD)
KIF2B
Human Genome Epidemiology (HuGE) Navigator
KIF2B
genes like me logo Genes that share disorders with KIF2B: view

No data available for UniProtKB/Swiss-Prot for KIF2B Gene

Publications for KIF2B Gene

  1. All kinesin superfamily protein, KIF, genes in mouse and human. (PMID: 11416179) Miki H. … Hirokawa N. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells. (PMID: 17538014) Manning A.L. … Compton D.A. (Mol. Biol. Cell 2007) 3 4
  4. A genome-wide study reveals copy number variants exclusive to childhood obesity cases. (PMID: 20950786) Glessner J.T. … Grant S.F. (Am. J. Hum. Genet. 2010) 3 49
  5. Plk1 regulates the kinesin-13 protein Kif2b to promote faithful chromosome segregation. (PMID: 22535524) Hood E.A. … Compton D.A. (Mol. Biol. Cell 2012) 3 4

Products for KIF2B Gene

Sources for KIF2B Gene

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