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Aliases for KIF2B Gene

Aliases for KIF2B Gene

  • Kinesin Family Member 2B 2 3 5

External Ids for KIF2B Gene

Previous GeneCards Identifiers for KIF2B Gene

  • GC17P049256
  • GC17P051900
  • GC17P047268

Summaries for KIF2B Gene

GeneCards Summary for KIF2B Gene

KIF2B (Kinesin Family Member 2B) is a Protein Coding gene. Diseases associated with KIF2B include Charcot-Marie-Tooth Disease, Type 4C and Hereditary Neuropathies. Among its related pathways are Golgi-to-ER retrograde transport and Mitotic Metaphase and Anaphase. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF2A.

UniProtKB/Swiss-Prot for KIF2B Gene

  • Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF2B Gene

Genomics for KIF2B Gene

Regulatory Elements for KIF2B Gene

Enhancers for KIF2B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KIF2B on UCSC Golden Path with GeneCards custom track

Genomic Location for KIF2B Gene

Chromosome:
17
Start:
53,822,878 bp from pter
End:
53,825,213 bp from pter
Size:
2,336 bases
Orientation:
Plus strand

Genomic View for KIF2B Gene

Genes around KIF2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF2B Gene

Proteins for KIF2B Gene

  • Protein details for KIF2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4N8-KIF2B_HUMAN
    Recommended name:
    Kinesin-like protein KIF2B
    Protein Accession:
    Q8N4N8
    Secondary Accessions:
    • Q96MA2
    • Q9BXG6

    Protein attributes for KIF2B Gene

    Size:
    673 amino acids
    Molecular mass:
    76254 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Osteosarcoma cells (U2OS) lacking KIF2B show disorganised often monopolar mitotic spindles, severely reduced velocity of chromosome movement and blocked cytokinesis. Bipolar mitotic spindles can be restored by simultaneous depletion of KIF2B, KIFC1 and NUMA1.

neXtProt entry for KIF2B Gene

Proteomics data for KIF2B Gene at MOPED

Post-translational modifications for KIF2B Gene

  • Phosphorylation at Thr-125 by PLK1 is required for activity in the correction of kinetochore-microtubules attachment errors, while phosphorylation at Ser-204 also by PLK1 is required for the kinetochore localization and activity in prometaphase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIF2B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for KIF2B

No data available for DME Specific Peptides for KIF2B Gene

Domains & Families for KIF2B Gene

Gene Families for KIF2B Gene

Protein Domains for KIF2B Gene

Suggested Antigen Peptide Sequences for KIF2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N4N8

UniProtKB/Swiss-Prot:

KIF2B_HUMAN :
  • Contains 1 kinesin motor domain.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.
Domain:
  • Contains 1 kinesin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.
genes like me logo Genes that share domains with KIF2B: view

Function for KIF2B Gene

Molecular function for KIF2B Gene

UniProtKB/Swiss-Prot Function:
Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity.
genes like me logo Genes that share phenotypes with KIF2B: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KIF2B Gene

Localization for KIF2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF2B Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Association with kinetochore is transient.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIF2B Gene COMPARTMENTS Subcellular localization image for KIF2B gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KIF2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005815 microtubule organizing center IEA --
GO:0005819 spindle IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with KIF2B: view

Pathways & Interactions for KIF2B Gene

genes like me logo Genes that share pathways with KIF2B: view

Gene Ontology (GO) - Biological Process for KIF2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007062 sister chromatid cohesion TAS --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007596 blood coagulation TAS --
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with KIF2B: view

No data available for SIGNOR curated interactions for KIF2B Gene

Drugs & Compounds for KIF2B Gene

(1) Drugs for KIF2B Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for KIF2B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KIF2B: view

Transcripts for KIF2B Gene

mRNA/cDNA for KIF2B Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(31) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KIF2B Gene

Kinesin family member 2B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIF2B Gene

No ASD Table

Relevant External Links for KIF2B Gene

GeneLoc Exon Structure for
KIF2B
ECgene alternative splicing isoforms for
KIF2B

Expression for KIF2B Gene

mRNA expression in normal human tissues for KIF2B Gene

mRNA differential expression in normal tissues according to GTEx for KIF2B Gene

This gene is overexpressed in Testis (x52.6).

Protein differential expression in normal tissues from HIPED for KIF2B Gene

This gene is overexpressed in Heart (57.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIF2B Gene



SOURCE GeneReport for Unigene cluster for KIF2B Gene Hs.226805

mRNA Expression by UniProt/SwissProt for KIF2B Gene

Q8N4N8-KIF2B_HUMAN
Tissue specificity: Highest level in lung. High level in ovary, moderate levels in heart, kidney, placenta, skeletal muscle and spleen (at protein level). Pancreas and spleen express a shorter isoform (at protein level).
genes like me logo Genes that share expression patterns with KIF2B: view

Protein tissue co-expression partners for KIF2B Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for KIF2B Gene

Orthologs for KIF2B Gene

This gene was present in the common ancestor of animals.

Orthologs for KIF2B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KIF2B 35
  • 80.7 (n)
  • 73.43 (a)
KIF2B 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIF2B 35
  • 85.53 (n)
  • 79.79 (a)
KIF2B 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kif2b 35
  • 79.59 (n)
  • 78.59 (a)
Kif2b 16
Kif2b 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KIF2B 35
  • 99.11 (n)
  • 98.66 (a)
KIF2B 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kif2b 35
  • 79.97 (n)
  • 78.92 (a)
oppossum
(Monodelphis domestica)
Mammalia KIF2B 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF2B 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIF2B 36
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIF2B 36
  • 50 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CABZ01117349.1 36
  • 41 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Klp10A 36
  • 36 (a)
ManyToMany
Klp59C 36
  • 41 (a)
ManyToMany
Klp59D 36
  • 36 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea klp-7 36
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToMany
Species with no ortholog for KIF2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KIF2B Gene

ENSEMBL:
Gene Tree for KIF2B (if available)
TreeFam:
Gene Tree for KIF2B (if available)

Paralogs for KIF2B Gene

Paralogs for KIF2B Gene

(3) SIMAP similar genes for KIF2B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KIF2B: view

Variants for KIF2B Gene

Sequence variations from dbSNP and Humsavar for KIF2B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs3803824 - 53,823,368(+) TACCG(C/T)CACGA reference, missense
rs9912492 - 53,823,415(+) CCTCA(C/G)GGGAC reference, missense
rs4561518 - 53,824,282(+) AAACA(C/T)CTGTC reference, missense
rs4561519 - 53,824,342(+) CAGGA(C/G)GGATA reference, missense
rs59657238 - 53,823,475(+) AGTCT(C/T)CCTGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for KIF2B Gene

Variant ID Type Subtype PubMed ID
nsv908620 CNV Loss 21882294

Variation tolerance for KIF2B Gene

Residual Variation Intolerance Score: 97.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.18; 87.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIF2B Gene

Human Gene Mutation Database (HGMD)
KIF2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF2B Gene

Disorders for KIF2B Gene

MalaCards: The human disease database

(2) MalaCards diseases for KIF2B Gene - From: GeneCards

Disorder Aliases PubMed IDs
charcot-marie-tooth disease, type 4c
  • charcot-marie-tooth neuropathy type 4c
hereditary neuropathies
  • neuropathy - hereditary
- elite association - COSMIC cancer census association via MalaCards
Search KIF2B in MalaCards View complete list of genes associated with diseases

Relevant External Links for KIF2B

Genetic Association Database (GAD)
KIF2B
Human Genome Epidemiology (HuGE) Navigator
KIF2B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIF2B
genes like me logo Genes that share disorders with KIF2B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIF2B Gene

Publications for KIF2B Gene

  1. All kinesin superfamily protein, KIF, genes in mouse and human. (PMID: 11416179) Miki H. … Hirokawa N. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3 23 67
  2. Plk1 regulates the kinesin-13 protein Kif2b to promote faithful chromosome segregation. (PMID: 22535524) Hood E.A. … Compton D.A. (Mol. Biol. Cell 2012) 3
  3. The microtubule-binding protein Cep170 promotes the targeting of the kinesin-13 depolymerase Kif2b to the mitotic spindle. (PMID: 23087211) Welburn J.P. … Cheeseman I.M. (Mol. Biol. Cell 2012) 3
  4. CLASP1, astrin and Kif2b form a molecular switch that regulates kinetochore-microtubule dynamics to promote mitotic progression and fidelity. (PMID: 20852589) Manning A.L. … Compton D.A. (EMBO J. 2010) 3
  5. A genome-wide study reveals copy number variants exclusive to childhood obesity cases. (PMID: 20950786) Glessner J.T. … Grant S.F. (Am. J. Hum. Genet. 2010) 3

Products for KIF2B Gene

Sources for KIF2B Gene

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