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Aliases for KIF2B Gene

Aliases for KIF2B Gene

  • Kinesin Family Member 2B 2 3 5

External Ids for KIF2B Gene

Previous GeneCards Identifiers for KIF2B Gene

  • GC17P049256
  • GC17P051900
  • GC17P047268

Summaries for KIF2B Gene

GeneCards Summary for KIF2B Gene

KIF2B (Kinesin Family Member 2B) is a Protein Coding gene. Diseases associated with KIF2B include Charcot-Marie-Tooth Disease, Type 4C and Hereditary Neuropathies. Among its related pathways are Innate Immune System and Golgi-to-ER retrograde transport. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF2A.

UniProtKB/Swiss-Prot for KIF2B Gene

  • Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity (PubMed:17538014). Plays a role in chromosome congression (PubMed:23891108).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF2B Gene

Genomics for KIF2B Gene

Regulatory Elements for KIF2B Gene

Enhancers for KIF2B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G053747 0.9 ENCODE 10.8 -73.8 -73831 2.2 HDAC1 PKNOX1 TBL1XR1 CREB3L1 ZSCAN4 TCF12 GATA2 ZBTB2 ELF4 NCOA1 KIF2B GC17P053748 RPS2P48
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KIF2B on UCSC Golden Path with GeneCards custom track

Genomic Location for KIF2B Gene

Chromosome:
17
Start:
53,822,878 bp from pter
End:
53,825,213 bp from pter
Size:
2,336 bases
Orientation:
Plus strand

Genomic View for KIF2B Gene

Genes around KIF2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF2B Gene

Proteins for KIF2B Gene

  • Protein details for KIF2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4N8-KIF2B_HUMAN
    Recommended name:
    Kinesin-like protein KIF2B
    Protein Accession:
    Q8N4N8
    Secondary Accessions:
    • Q96MA2
    • Q9BXG6

    Protein attributes for KIF2B Gene

    Size:
    673 amino acids
    Molecular mass:
    76254 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Osteosarcoma cells (U2OS) lacking KIF2B show disorganised often monopolar mitotic spindles, severely reduced velocity of chromosome movement and blocked cytokinesis. Bipolar mitotic spindles can be restored by simultaneous depletion of KIF2B, KIFC1 and NUMA1.

neXtProt entry for KIF2B Gene

Post-translational modifications for KIF2B Gene

  • Phosphorylation at Thr-125 by PLK1 is required for activity in the correction of kinetochore-microtubules attachment errors, while phosphorylation at Ser-204 also by PLK1 is required for the kinetochore localization and activity in prometaphase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIF2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KIF2B Gene

Domains & Families for KIF2B Gene

Gene Families for KIF2B Gene

Protein Domains for KIF2B Gene

Suggested Antigen Peptide Sequences for KIF2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N4N8

UniProtKB/Swiss-Prot:

KIF2B_HUMAN :
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.
genes like me logo Genes that share domains with KIF2B: view

Function for KIF2B Gene

Molecular function for KIF2B Gene

UniProtKB/Swiss-Prot Function:
Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity (PubMed:17538014). Plays a role in chromosome congression (PubMed:23891108).

Gene Ontology (GO) - Molecular Function for KIF2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0003777 microtubule motor activity IBA --
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
GO:0016887 ATPase activity IBA --
genes like me logo Genes that share ontologies with KIF2B: view
genes like me logo Genes that share phenotypes with KIF2B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for KIF2B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KIF2B Gene

Localization for KIF2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF2B Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Association with kinetochore is transient.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIF2B gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KIF2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0000776 kinetochore IEA --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus IDA --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with KIF2B: view

Pathways & Interactions for KIF2B Gene

genes like me logo Genes that share pathways with KIF2B: view

Gene Ontology (GO) - Biological Process for KIF2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS --
GO:0007018 microtubule-based movement TAS --
GO:0007019 microtubule depolymerization IMP 19060894
GO:0007049 cell cycle IEA --
GO:0007062 sister chromatid cohesion TAS --
genes like me logo Genes that share ontologies with KIF2B: view

No data available for SIGNOR curated interactions for KIF2B Gene

Drugs & Compounds for KIF2B Gene

(1) Drugs for KIF2B Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for KIF2B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KIF2B: view

Transcripts for KIF2B Gene

mRNA/cDNA for KIF2B Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(31) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KIF2B Gene

Kinesin family member 2B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for KIF2B

Alternative Splicing Database (ASD) splice patterns (SP) for KIF2B Gene

No ASD Table

Relevant External Links for KIF2B Gene

GeneLoc Exon Structure for
KIF2B
ECgene alternative splicing isoforms for
KIF2B

Expression for KIF2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIF2B Gene

mRNA differential expression in normal tissues according to GTEx for KIF2B Gene

This gene is overexpressed in Testis (x52.6).

Protein differential expression in normal tissues from HIPED for KIF2B Gene

This gene is overexpressed in Heart (57.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KIF2B Gene



Protein tissue co-expression partners for KIF2B Gene

NURSA nuclear receptor signaling pathways regulating expression of KIF2B Gene:

KIF2B

SOURCE GeneReport for Unigene cluster for KIF2B Gene:

Hs.226805

mRNA Expression by UniProt/SwissProt for KIF2B Gene:

Q8N4N8-KIF2B_HUMAN
Tissue specificity: Highest level in lung. High level in ovary, moderate levels in heart, kidney, placenta, skeletal muscle and spleen (at protein level). Pancreas and spleen express a shorter isoform (at protein level).

Evidence on tissue expression from TISSUES for KIF2B Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with KIF2B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIF2B Gene

Orthologs for KIF2B Gene

This gene was present in the common ancestor of animals.

Orthologs for KIF2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF2B 34 35
  • 99.11 (n)
dog
(Canis familiaris)
Mammalia KIF2B 34 35
  • 85.53 (n)
cow
(Bos Taurus)
Mammalia KIF2B 34 35
  • 80.7 (n)
rat
(Rattus norvegicus)
Mammalia Kif2b 34
  • 79.97 (n)
mouse
(Mus musculus)
Mammalia Kif2b 34 16 35
  • 79.59 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KIF2B 35
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIF2B 35
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIF2B 35
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIF2B 35
  • 50 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CABZ01117349.1 35
  • 41 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Klp59C 35
  • 41 (a)
ManyToMany
Klp10A 35
  • 36 (a)
ManyToMany
Klp59D 35
  • 36 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea klp-7 35
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 43 (a)
OneToMany
Species where no ortholog for KIF2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KIF2B Gene

ENSEMBL:
Gene Tree for KIF2B (if available)
TreeFam:
Gene Tree for KIF2B (if available)

Paralogs for KIF2B Gene

Paralogs for KIF2B Gene

(3) SIMAP similar genes for KIF2B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KIF2B: view

Variants for KIF2B Gene

Sequence variations from dbSNP and Humsavar for KIF2B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1001128863 -- 53,824,145(+) CTGGA(A/C)GAAGA reference, missense
rs1005210451 -- 53,822,730(+) TGTTC(A/T)TTCTC upstream-variant-2KB
rs1005264267 -- 53,822,516(+) ATCGA(G/T)TCCTG upstream-variant-2KB
rs1006226691 -- 53,825,277(+) CCCAC(C/T)CCCTA downstream-variant-500B
rs1007481877 -- 53,821,652(+) CTGCA(C/T)ACAAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KIF2B Gene

Variant ID Type Subtype PubMed ID
dgv3265n100 CNV gain 25217958
nsv1067551 CNV gain 25217958

Variation tolerance for KIF2B Gene

Residual Variation Intolerance Score: 97.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.18; 87.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIF2B Gene

Human Gene Mutation Database (HGMD)
KIF2B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIF2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF2B Gene

Disorders for KIF2B Gene

MalaCards: The human disease database

(2) MalaCards diseases for KIF2B Gene - From: GeneCards

Disorder Aliases PubMed IDs
charcot-marie-tooth disease, type 4c
  • charcot-marie-tooth disease type 4c
hereditary neuropathies
  • neuropathy - hereditary
- elite association - COSMIC cancer census association via MalaCards
Search KIF2B in MalaCards View complete list of genes associated with diseases

Relevant External Links for KIF2B

Genetic Association Database (GAD)
KIF2B
Human Genome Epidemiology (HuGE) Navigator
KIF2B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIF2B
genes like me logo Genes that share disorders with KIF2B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIF2B Gene

Publications for KIF2B Gene

  1. All kinesin superfamily protein, KIF, genes in mouse and human. (PMID: 11416179) Miki H. … Hirokawa N. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3 22 64
  2. Lateral to end-on conversion of chromosome-microtubule attachment requires kinesins CENP-E and MCAK. (PMID: 23891108) Shrestha R.L. … Draviam V.M. (Curr. Biol. 2013) 3 4 64
  3. Plk1 regulates the kinesin-13 protein Kif2b to promote faithful chromosome segregation. (PMID: 22535524) Hood E.A. … Compton D.A. (Mol. Biol. Cell 2012) 3 4 64
  4. A genome-wide study reveals copy number variants exclusive to childhood obesity cases. (PMID: 20950786) Glessner J.T. … Grant S.F. (Am. J. Hum. Genet. 2010) 3 46 64
  5. The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells. (PMID: 17538014) Manning A.L. … Compton D.A. (Mol. Biol. Cell 2007) 3 4 64

Products for KIF2B Gene

  • Addgene plasmids for KIF2B

Sources for KIF2B Gene

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