Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KIF2A Gene

protein-coding   GIFtS: 60
GCID: GC05P061601

Kinesin Heavy Chain Member 2A

(Previous name: kinesin heavy chain member 2)
(Previous symbol: KIF2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Kinesin Heavy Chain Member 2A1 2     kinesin-22
KIF21 2 3 5     Kinesin-Like Protein KIF2A2
Kinesin Heavy Chain Member 21     KNS23
CDCBM32     Kinesin-23
HK22     hK23
Kinesin, Heavy Chain, 22     

External Ids:    HGNC: 63181   Entrez Gene: 37962   Ensembl: ENSG000000687967   OMIM: 6025915   UniProtKB: O001393   

Export aliases for KIF2A gene to outside databases

Previous GC identifers: GC05P061638 GC05P058558


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KIF2A Gene:
The protein encoded by this gene is a plus end-directed motor required for normal mitotic progression. The encoded
protein is required for normal spindle activity during mitosis and is necessary for normal brain development.
Several transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Sep
2011)

GeneCards Summary for KIF2A Gene: 
KIF2A (kinesin heavy chain member 2A) is a protein-coding gene. Diseases associated with KIF2A include tongue cancer, and vaccinia, and among its related super-pathways are Mitotic Anaphase and Mitotic Prometaphase. GO annotations related to this gene include motor activity and microtubule motor activity. An important paralog of this gene is KIF22.

UniProtKB/Swiss-Prot: KIF2A_HUMAN, O00139
Function: Plus end-directed microtubule-dependent motor required for normal brain development. May regulate
microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal
congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes
spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity

summary for KIF2A Gene:
Mitochondrial Hexokinases catalyze the first essential step of glucose metabolism, the conversion of glucose
into glucose-6-phosphate. This directly couples extramitochondrial glycolysis to intramitochondrial
oxidative phosphorylation. There are two subtypes of mitochondrial hexokinases, HK1 and HK2, each of which
has four isozymes designated hexokinase I, II, III and IV. HK1 and HK2 are both localized to the outer
mitochondrial membrane, with HK1 being found in nervous tissue and HK2 in insulin-responsive tissues such as
skeletal muscle. Activation of mitochondrial hexokinases is regulated by Akt/PKB-mediated phosphorylation
and they are subject to inhibiton by their end product, glucose-6-phosphate. In addition to glucose
metabolism, mitochondrial hexokinases have been implicated in antiapoptotic and cell survival signaling.

Gene Wiki entry for KIF2A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_006713.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KIF2A gene promoter:
         ISGF-3   AP-2alpha isoform 3   CUTL1   AP-2alpha isoform 2   Cdc5   FOXJ2 (long isoform)   FOXJ2   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKIF2A promoter sequence
   Search SABiosciences Chromatin IP Primers for KIF2A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIF2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q12-q13   Ensembl cytogenetic band:  5q12.1   HGNC cytogenetic band: 5q12-q13

KIF2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIF2A gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P061601:  view genomic region     (about GC identifiers)

Start:
61,601,989 bp from pter      End:
61,833,076 bp from pter
Size:
231,088 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KIF2A_HUMAN, O00139 (See protein sequence)
Recommended Name: Kinesin-like protein KIF2A  
Size: 706 amino acids; 79955 Da
Subunit: Interacts with AURKA, PSRC1 and PLK1
Subcellular location: Cytoplasm (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center,
centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, spindle. Note=Localized to the
spindle microtubules and spindle poles from prophase to metaphase. Efficient targeting to spindle microtubules
and spindle poles requires the kinase activity of PLK1. Recruited to mitotic spindles by interaction with PSRC1
Miscellaneous: HeLa cells lacking KIF2A show asymmetric or monopolar mitotic spindles. Osteosarcoma cells (U2OS)
lacking KIF2A or KIF2B show disorganised or monopolar mitotic spindles
Sequence caution: Sequence=AAP84320.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for KIF2A:
2GRY (3D)    
Secondary accessions: A5YM42 A5YM54 B4DY54 D3DW97 E9PB70 Q7Z5I3 Q8N5Q7
Alternative splicing: 5 isoforms:  O00139-3   O00139-1   O00139-2   O00139-4   O00139-5   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for KIF2A: NX_O00139

Explore proteomics data for KIF2A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O00139

  • KIF2A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KIF2A Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001091981.1  NP_001230881.1  NP_001230882.1  NP_004511.2  

    ENSEMBL proteins: 
     ENSP00000385622   ENSP00000370493   ENSP00000423542   ENSP00000385000   ENSP00000425411  
     ENSP00000423772   ENSP00000421041  
    Reactome Protein details: O00139
    Human Recombinant Protein Products for KIF2A: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for KIF2A
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for KIF2A
    GenScript Custom Purified and Recombinant Proteins Services for KIF2A
    Novus Biologicals KIF2A Protein
    Novus Biologicals KIF2A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KIF2A 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922colocalizes with spindle pole IDA18411309
    GO:0005813centrosome IDA--
    GO:0005829cytosol TAS--
    GO:0005871kinesin complex IEA--
    GO:0005875microtubule associated complex ----

    KIF2A for ontologies           About GeneDecksing



    KIF2A Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of KIF2A
    Browse R&D Systems for Antibodies
    OriGene Antibodies for KIF2A
    OriGene Custom Antibody Services for KIF2A
    GenScript Custom Superior Antibodies Services for KIF2A
    Novus Biologicals KIF2A Antibodies
    Abcam antibodies for KIF2A
    Cloud-Clone Corp. Antibodies for KIF2A 
    ThermoFisher Antibodies for KIF2A
    LSBio Antibodies in human, mouse, rat for KIF2A 

    Assay Products for KIF2A: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KIF2A
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KIF2A
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for KIF2A 
    Cloud-Clone Corp. CLIAs for KIF2A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    KIF: Kinesins

    3 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR001752 Kinesin_motor_dom
     IPR019821 Kinesin_motor_CS

    Graphical View of Domain Structure for InterPro Entry O00139

    ProtoNet protein and cluster: O00139

    1 Blocks protein domain: IPB001752 Kinesin

    UniProtKB/Swiss-Prot: KIF2A_HUMAN, O00139
    Similarity: Belongs to the kinesin-like protein family. MCAK/KIF2 subfamily
    Similarity: Contains 1 kinesin-motor domain


    KIF2A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KIF2A_HUMAN, O00139
    Function: Plus end-directed microtubule-dependent motor required for normal brain development. May regulate
    microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal
    congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes
    spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003774motor activity TAS9177777
    GO:0003777microtubule motor activity IEA--
    GO:0005515protein binding IPI18411309
    GO:0005524ATP binding IEA--
    GO:0008017microtubule binding IEA--
         
    KIF2A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KIF2A:
     Upregulation of Wnt/beta-caten 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Kif2a):
     behavior/neurological  cellular  mortality/aging  nervous system  no phenotypic analysis 

    KIF2A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Kif2atm1Noh for KIF2A

       inGenious Targeting Laboratory - Custom generated mouse model solutions for KIF2A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KIF2A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KIF2A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KIF2A 

    miRNA
    Products:
        
    miRTarBase miRNAs that target KIF2A:
    hsa-mir-1 (MIRT003853), hsa-mir-183 (MIRT004016)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KIF2A
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate KIF2A (see all 23):
    hsa-miR-3673 hsa-miR-520d-5p hsa-miR-3614-3p hsa-miR-202 hsa-miR-15a hsa-miR-218 hsa-miR-3692 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidKIF2A 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KIF2A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIF2A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KIF2A
    Sirion Biotech Customized adenovirus for overexpression of KIF2A

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for KIF2A (see all 12)
    OriGene ORF clones in mouse, rat for KIF2A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): KIF2A (NM_004520)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KIF2A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIF2A
    Sirion Biotech Customized lentivirus for stable overexpression of KIF2A 
                         Customized lentivirus expression plasmids for stable overexpression of KIF2A 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KIF2A
    Search LifeMap BioReagents cell lines for KIF2A
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF2A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KIF2A About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1M Phase
    Mitotic Anaphase0.94
    M Phase0.88
    Separation of Sister Chromatids0.94
    Mitotic M-M/G1 phases0.88
    Mitotic Metaphase and Anaphase0.94
    2Resolution of Sister Chromatid Cohesion
    Resolution of Sister Chromatid Cohesion0.93
    Mitotic Prometaphase0.93
    3Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84
    4Immune System
    Immune System0.56
    Adaptive Immune System0.56
    5MHC class II antigen presentation
    MHC class II antigen presentation0.32
    Kinesins0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for KIF2A
        PLK1 signaling events

    5/15        Reactome Pathways for KIF2A (see all 15)
        Hemostasis
    Mitotic Metaphase and Anaphase
    Mitotic Prometaphase
    Resolution of Sister Chromatid Cohesion
    Mitotic Anaphase



    KIF2A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIF2A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/87 Interacting proteins for KIF2A (O001393 ENSP000003850004) via UniProtKB, MINT, STRING, and/or I2D (see all 87)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KLC2Q9H0B63, ENSP000003148374I2D: score=1 STRING: ENSP00000314837
    TSNAXQ995983, ENSP000003555994I2D: score=1 STRING: ENSP00000355599
    KLC1Q078663, ENSP000004149824I2D: score=1 STRING: ENSP00000414982
    CLSTN1O949853, ENSP000003665134I2D: score=1 STRING: ENSP00000366513
    PSMB3P497203I2D: score=5 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0007018microtubule-based movement TAS--
    GO:0007052mitotic spindle organization IDA18411309
    GO:0007067mitosis IEA--
    GO:0007399nervous system development IEA--

    KIF2A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for KIF2A available from Tocris Bioscience    About this table
    CompoundAction CAS #
    2-Deoxy-D-glucoseNon-metabolizable glucose analog; hexokinase substrate[154-17-6]
    LonidamineMitochondrial hexokinase inhibitor[50264-69-2]

    Search CenterWatch for drugs/clinical trials and news about KIF2A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KIF2A gene (4 alternative transcripts): 
    NM_001098511.2  NM_001243952.1  NM_001243953.1  NM_004520.4  

    Unigene Cluster for KIF2A:

    Kinesin heavy chain member 2A
    Hs.558351  [show with all ESTs]
    Unigene Representative Sequence: NM_001243952
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000401507 ENST00000509663 ENST00000381103(uc003jsz.4 uc003jsx.4 uc010iwp.3 uc003jsy.4 uc010iwq.3)
    ENST00000514082 ENST00000407818 ENST00000504883 ENST00000512541 ENST00000506857
    ENST00000512006 ENST00000509624
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KIF2A
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate KIF2A (see all 23):
    hsa-miR-3673 hsa-miR-520d-5p hsa-miR-3614-3p hsa-miR-202 hsa-miR-15a hsa-miR-218 hsa-miR-3692 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidKIF2A 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KIF2A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIF2A
    Clone
    Products:
         
    OriGene clones in human, mouse for KIF2A (see all 12)
    OriGene ORF clones in mouse, rat for KIF2A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): KIF2A (NM_004520)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KIF2A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIF2A
    Sirion Biotech Customized lentivirus for stable overexpression of KIF2A 
                         Customized lentivirus expression plasmids for stable overexpression of KIF2A 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for KIF2A
    OriGene qSTAR qPCR primer pairs in human, mouse for KIF2A
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KIF2A
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIF2A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIF2A

    Additional mRNA sequence: 

    AF119867.2 AK057153.1 AK297347.1 AK302270.1 AK307880.1 AK315866.1 AY317140.1 AY429552.1 
    BC031828.2 BC047544.1 EF560716.1 EF560728.1 Y08319.1 

    13 DOTS entries:

    DT.454311  DT.100862004  DT.95119316  DT.101986330  DT.92005971  DT.120847501  DT.95276142  DT.97837631 
    DT.100681062  DT.92446375  DT.95355297  DT.100645026  DT.75172654 

    24/361 AceView cDNA sequences (see all 361):

    AA866142 CA393815 AA429678 BQ695086 BQ772907 BC067275 AI280606 AW955281 
    BM696039 BX414999 AA291244 BU608148 AI206915 CA432271 AI692572 AA031268 
    AJ714491 BM713752 CB053653 AL538419 BU729880 BM802813 AW512269 BE281129 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for KIF2A (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
    SP1:                                            -                                                     -                                                         
    SP2:                                                                                                  -                                                         
    SP3:                                            -                                                                                                               
    SP4:                                      -     -                                                                                                               
    SP5:        -     -     -     -     -     -     -     -     -                                         -                                                         

    ExUns: 20a · 20b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for KIF2A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KIF2A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGATTATAAT
    KIF2A Expression
    About this image


    See KIF2A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KIF2A

    SOURCE GeneReport for Unigene cluster: Hs.558351
        SABiosciences Custom PCR Arrays for KIF2A
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for KIF2A
    OriGene qSTAR qPCR primer pairs in human, mouse for KIF2A
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KIF2A
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIF2A
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIF2A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF2A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for KIF2A gene from 8/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kif2a1 , 5 kinesin family member 2A1, 5 92.06(n)1
    98.16(a)1
      13 (58.06 cM)5
    165631  NM_001145779.11  NP_001139251.11 
     1069589965 
    chicken
    (Gallus gallus)
    Aves KIF2A1 kinesin heavy chain member 2A 87.58(n)
    95.33(a)
      427156  NM_001039312.2  NP_001034401.2 
    lizard
    (Anolis carolinensis)
    Reptilia KIF2A6
    kinesin heavy chain member 2A
    87(a)
    1 ↔ 1
    2(8244688-8322450)
    African clawed frog
    (Xenopus laevis)
    Amphibia kif2-A-prov2 kinesin-related protein XKIF2 80.47(n)    U36486.2 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1036701 zgc:103670 73.48(n)
    85.29(a)
      447926  NM_001004664.2  NP_001004664.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Klp10A1 CG1453-PA 52.19(n)
    54.7(a)
      32049  NM_167270.1  NP_727494.1 
    worm
    (Caenorhabditis elegans)
    Secernentea klp-71 Protein KLP-7 52.04(n)
    52.81(a)
      176511  NM_001027506.1  NP_001022677.1 
    rice
    (Oryza sativa)
    Liliopsida Os.163032 Oryza sativa (japonica cultivar-group) cDNA cloneJ023079H05, full insert sequence less 74.95(n)    NM_192882.1 


    ENSEMBL Gene Tree for KIF2A (if available)
    TreeFam Gene Tree for KIF2A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KIF2A gene
    KIF222  KIF18A2  KIF242  KIF2B2  KIF18B2  KIF2C2  KIF192  
    7 SIMAP similar genes for KIF2A using alignment to 4 protein entries:     KIF2A_HUMAN (see all proteins):
    KIF2B    KIF2C    KIF5C    KIF5B    KIF3A    KIF6
    KIF5A

    KIF2A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for KIF2A
    PGOHUM00000250058


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1531 SNPs in KIF2A are shown (see all 1531)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs358080561,2
    C,F--61600006(+) TACAAA/C/G/
            
    AAATT
    4 -- us2k13NA 124
    rs1882497681,2
    --61600072(+) GAGAAA/TAACTT 4 -- us2k10--------
    rs1458113351,2
    --61600118(+) CATGCC/TACTGC 4 -- us2k10--------
    rs1115474421,2
    C--61600160(+) GTCTCTAA/-TAATA 4 -- cds11Minor allele frequency- -:0.50CSA 2
    rs131597501,2
    C,A--61600316(+) GAGCTC/TGAAGA 4 -- us2k16Minor allele frequency- T:0.43NA WA CSA EA 363
    rs133611431,2
    C,F,H--61600367(+) TAAACC/GCTGAT 4 -- us2k111Minor allele frequency- G:0.42NS EA NA WA CSA 778
    rs126969881,2
    C,F--61600395(+) GAAACA/CGGGGT 4 -- us2k112Minor allele frequency- C:0.13NA WA CSA EA 375
    rs1119562981,2
    C,F--61600644(+) ATAAGC/TATTGA 4 -- us2k12Minor allele frequency- T:0.18CSA WA 120
    rs133612191,2
    C,F--61600714(+) AGGGAG/CATTAT 4 -- us2k17Minor allele frequency- C:0.32NA WA EA 366
    rs131787291,2
    C,F--61600845(+) accccG/Atctct 4 -- us2k11Minor allele frequency- A:0.50NA 2

    HapMap Linkage Disequilibrium report for KIF2A (61601989 - 61833076 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for KIF2A:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv273821CNV Insertion20981092
    esv268685CNV Insertion20981092
    nsv881728CNV Loss21882294
    nsv881727CNV Loss21882294
    nsv830318CNV Gain17160897
    nsv881726CNV Gain21882294
    esv35035CNV Gain17911159
    essv5631CNV CNV17122850
    dgv1801e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KIF2A
    DNA2.0 Custom Variant and Variant Library Synthesis for KIF2A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602591    OMIM disorders: --

    5 diseases for KIF2A:    About MalaCards
    tongue cancer    vaccinia    osteosarcoma    schizophrenia
    breast cancer

    1 disease from the University of Copenhagen DISEASES database for KIF2A:
    Tongue cancer

    KIF2A for disorders           About GeneDecksing

    Genetic Association Database (GAD): KIF2A
    Human Genome Epidemiology (HuGE) Navigator: KIF2A (1 document)

    Export disorders for KIF2A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KIF2A gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with KIF2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel human kinesin-related gene (HK2) by the cDNA differential display technique. (PubMed id 9177777)1, 2, 3, 9 Debernardi S.... Delia D. (1997)
    2. A family-based association study of kinesin heavy chain member 2 gene (KIF2) and schizophrenia. (PubMed id 16959419)1, 4, 9 Li C....He L. (2006)
    3. Plk1 and Aurora A regulate the depolymerase activity and the cellular localization of Kif2a. (PubMed id 19351716)1, 2 Jang C.Y.... Fang G. (2009)
    4. DDA3 recruits microtubule depolymerase Kif2a to spindle poles and controls spindle dynamics and mitotic chromosome movement. (PubMed id 18411309)1, 2 Jang C.Y....Fang G. (2008)
    5. The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells. (PubMed id 17538014)1, 2 Manning A.L....Compton D.A. (2007)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Examining post-translational modification-mediated pro tein-protein interactions using a chemical proteomics approach. (PubMed id 23281010)1 Li X....Kapoor T.M. (2013)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    9. NOTCH1 nuclear interactome reveals key regulators of i ts transcriptional activity and oncogenic function. (PubMed id 23022380)1 Yatim A....Benkirane M. (2012)
    10. Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF). (PubMed id 21907836)1 Zhao J....Yang P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3796 HGNC: 6318 AceView: KIF2 Ensembl:ENSG00000068796 euGenes: HUgn3796
    ECgene: KIF2A H-InvDB: KIF2A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KIF2A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KIF2A gene:
    Search GeneIP for patents involving KIF2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of KIF2A
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for KIF2A   OriGene RNAi products in human, mouse, rat for KIF2A  
     OriGene qPCR primer pairs and template standards for KIF2A   OriGene Protein Over-expression Lysate for KIF2A  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for KIF2A  
     OriGene qSTAR qPCR primer pairs in human, mouse for KIF2A   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for KIF2A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KIF2A   OriGene Custom Protein Services for KIF2A  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KIF2A
     QIAGEN SeqTarget long-range PCR primers for resequencing KIF2A
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIF2A
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIF2A
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIF2A
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIF2A
     GenScript Custom Purified and Recombinant Proteins Services for KIF2A GenScript cDNA clones with any tag delivered in your preferred vector for KIF2A
     GenScript Custom Assay Services for KIF2A GenScript Custom Superior Antibodies Services for KIF2A
     GenScript Custom overexpressing Cell Line Services for KIF2A CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in KIF2A promoter
     Search Chromatin IP Primers for KIF2A
     RT2 qPCR Primer Assay in human, mouse, rat KIF2A
     Search GNC Networks for KIF2A
     SABiosciences Custom PCR Arrays for KIF2A
     Tocris compounds for KIF2A
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     KIF2A antibodies
     KIF2A proteins
     KIF2A lysates
     Antibodies for KIF2A
     See all of Abcam's Antibodies, Kits and Proteins for KIF2A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for KIF2A
     Antibodies for KIF2A
     ELISAs for KIF2A
     CLIAs for KIF2A
     Search LifeMap BioReagents cell lines for KIF2A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF2A
     SwitchGear 3'UTR luciferase reporter plasmids for KIF2A
     SwitchGear Promoter luciferase reporter plasmids for KIF2A
     ThermoFisher Antibodies for KIF2A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIF2A
     inGenious Targeting Laboratory - Custom generated mouse model solutions for KIF2A
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KIF2A
    Customized:
     lentivirus for stable overexpression of KIF2A
     lentivirus expression plasmids for stable overexpression of KIF2A
     adenovirus for overexpression of KIF2A
     LSBio Antibodies in human, mouse, rat for KIF2A
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KIF2A gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4