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Aliases for KIF2A Gene

Aliases for KIF2A Gene

  • Kinesin Heavy Chain Member 2A 2 3
  • Kinesin-2 3 4
  • CDCBM3 3 6
  • KIF2 3 4
  • HK2 3 4
  • Kinesin Heavy Chain Member 2 2
  • Kinesin-Like Protein KIF2A 3
  • Kinesin, Heavy Chain, 2 3
  • KNS2 4

External Ids for KIF2A Gene

Previous HGNC Symbols for KIF2A Gene

  • KIF2

Previous GeneCards Identifiers for KIF2A Gene

  • GC05P061638
  • GC05P058558
  • GC05P061601

Summaries for KIF2A Gene

Entrez Gene Summary for KIF2A Gene

  • The protein encoded by this gene is a plus end-directed motor required for normal mitotic progression. The encoded protein is required for normal spindle activity during mitosis and is necessary for normal brain development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for KIF2A Gene

KIF2A (Kinesin Heavy Chain Member 2A) is a Protein Coding gene. Diseases associated with KIF2A include cortical dysplasia, complex, with other brain malformations 3 and cortical dysplasia, complex, with other brain malformations. Among its related pathways are Class I MHC mediated antigen processing and presentation and Cell Cycle, Mitotic. GO annotations related to this gene include microtubule binding and motor activity. An important paralog of this gene is KIF2B.

UniProtKB/Swiss-Prot for KIF2A Gene

  • Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity.

Gene Wiki entry for KIF2A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF2A Gene

Genomics for KIF2A Gene

Genomic Location for KIF2A Gene

Start:
62,306,162 bp from pter
End:
62,537,249 bp from pter
Size:
231,088 bases
Orientation:
Plus strand

Genomic View for KIF2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIF2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF2A Gene

Proteins for KIF2A Gene

  • Protein details for KIF2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00139-KIF2A_HUMAN
    Recommended name:
    Kinesin-like protein KIF2A
    Protein Accession:
    O00139
    Secondary Accessions:
    • A5YM42
    • A5YM54
    • B4DY54
    • D3DW97
    • E9PB70
    • Q7Z5I3
    • Q8N5Q7

    Protein attributes for KIF2A Gene

    Size:
    706 amino acids
    Molecular mass:
    79955 Da
    Quaternary structure:
    • Interacts with AURKA, PSRC1 and PLK1.
    Miscellaneous:
    • HeLa cells lacking KIF2A show asymmetric or monopolar mitotic spindles. Osteosarcoma cells (U2OS) lacking KIF2A or KIF2B show disorganised or monopolar mitotic spindles
    SequenceCaution:
    • Sequence=AAP84320.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KIF2A Gene

    Alternative splice isoforms for KIF2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF2A Gene

Proteomics data for KIF2A Gene at MOPED

Post-translational modifications for KIF2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIF2A Gene

No data available for DME Specific Peptides for KIF2A Gene

Domains for KIF2A Gene

Gene Families for KIF2A Gene

HGNC:
  • KIF :Kinesins

Protein Domains for KIF2A Gene

Suggested Antigen Peptide Sequences for KIF2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00139

UniProtKB/Swiss-Prot:

KIF2A_HUMAN :
  • O00139
Domain:
  • Contains 1 kinesin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.
genes like me logo Genes that share domains with KIF2A: view

Function for KIF2A Gene

Molecular function for KIF2A Gene

UniProtKB/Swiss-Prot Function: Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity.

Gene Ontology (GO) - Molecular Function for KIF2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity TAS 9177777
GO:0003777 microtubule motor activity IBA --
GO:0005515 protein binding IPI 18411309
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
genes like me logo Genes that share ontologies with KIF2A: view
genes like me logo Genes that share phenotypes with KIF2A: view

Animal Models for KIF2A Gene

MGI Knock Outs for KIF2A:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for KIF2A Gene

Localization for KIF2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF2A Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, spindle. Note=Localized to the spindle microtubules and spindle poles from prophase to metaphase. Efficient targeting to spindle microtubules and spindle poles requires the kinase activity of PLK1. Recruited to mitotic spindles by interaction with PSRC1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIF2A Gene COMPARTMENTS Subcellular localization image for KIF2A gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for KIF2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 colocalizes_with spindle pole IDA 18411309
GO:0005813 centrosome IDA 21399614
GO:0005829 cytosol TAS --
GO:0005871 kinesin complex IBA --
GO:0005876 colocalizes_with spindle microtubule IDA 18411309
genes like me logo Genes that share ontologies with KIF2A: view

Pathways for KIF2A Gene

genes like me logo Genes that share pathways with KIF2A: view

Gene Ontology (GO) - Biological Process for KIF2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0006200 obsolete ATP catabolic process --
GO:0007018 microtubule-based movement TAS --
GO:0007019 microtubule depolymerization IBA --
GO:0007052 mitotic spindle organization IDA 18411309
genes like me logo Genes that share ontologies with KIF2A: view

Transcripts for KIF2A Gene

Unigene Clusters for KIF2A Gene

Kinesin heavy chain member 2A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIF2A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - -
SP2: -
SP3: -
SP4: - -
SP5: - - - - - - - - - -
SP6:

ExUns: 20a · 20b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for KIF2A Gene

GeneLoc Exon Structure for
KIF2A
ECgene alternative splicing isoforms for
KIF2A

Expression for KIF2A Gene

mRNA expression in normal human tissues for KIF2A Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIF2A Gene

SOURCE GeneReport for Unigene cluster for KIF2A Gene Hs.558351

genes like me logo Genes that share expressions with KIF2A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KIF2A Gene

Orthologs for KIF2A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KIF2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF2A 35
  • 99.48 (n)
  • 99.38 (a)
KIF2A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIF2A 35
  • 95.25 (n)
  • 98.64 (a)
KIF2A 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIF2A 35
  • 96.82 (n)
  • 99.19 (a)
KIF2A 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kif2a 35
  • 92.06 (n)
  • 98.16 (a)
Kif2a 16
Kif2a 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIF2A 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF2A 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kif2a 35
  • 91.73 (n)
  • 98.87 (a)
chicken
(Gallus gallus)
Aves KIF2A 35
  • 87.58 (n)
  • 95.33 (a)
KIF2A 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIF2A 36
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia kif2-A-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia kif2a 35
  • 82.46 (n)
  • 93.12 (a)
Str.20433 35
zebrafish
(Danio rerio)
Actinopterygii KIF2A 36
  • 85 (a)
OneToOne
zgc:103670 35
  • 74.1 (n)
  • 85.29 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000159 35
  • 52.5 (n)
  • 54.78 (a)
fruit fly
(Drosophila melanogaster)
Insecta Klp10A 35
  • 50.55 (n)
  • 51.65 (a)
Klp10A 36
  • 45 (a)
ManyToMany
Klp59C 36
  • 46 (a)
ManyToMany
Klp59D 36
  • 43 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea klp-7 36
  • 41 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.16303 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
OneToMany
Species with no ortholog for KIF2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIF2A Gene

ENSEMBL:
Gene Tree for KIF2A (if available)
TreeFam:
Gene Tree for KIF2A (if available)

Paralogs for KIF2A Gene

Paralogs for KIF2A Gene

Selected SIMAP similar genes for KIF2A Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for KIF2A Gene

genes like me logo Genes that share paralogs with KIF2A: view

Variants for KIF2A Gene

Sequence variations from dbSNP and Humsavar for KIF2A Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs11962 -- 62,386,105(-) ATGAC(A/T)AGGAA utr-variant-3-prime
rs15807 -- 62,387,298(+) ATGGA(C/G)AACTG downstream-variant-500B
rs35008 -- 62,357,930(+) CATTC(C/T)GAGTC intron-variant
rs35009 -- 62,358,360(-) AATTT(C/G)AAGGT intron-variant
rs152189 -- 62,384,621(+) TGTTA(C/T)TGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF2A Gene

Variant ID Type Subtype PubMed ID
dgv1801e1 CNV Complex 17122850
nsv830318 CNV Gain 17160897
nsv881726 CNV Gain 21882294
nsv881727 CNV Loss 21882294
nsv881728 CNV Loss 21882294
esv268685 CNV Insertion 20981092
esv273821 CNV Insertion 20981092
essv5631 CNV CNV 17122850
esv35035 CNV Gain 17911159

Relevant External Links for KIF2A Gene

HapMap Linkage Disequilibrium report
KIF2A
Human Gene Mutation Database (HGMD)
KIF2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF2A Gene

Disorders for KIF2A Gene

(1) OMIM Diseases for KIF2A Gene (602591)

UniProtKB/Swiss-Prot

KIF2A_HUMAN
  • Cortical dysplasia, complex, with other brain malformations 3 (CDCBM3) [MIM:615411]: A disorder of aberrant neuronal migration and disturbed axonal guidance. Clinical features include early-onset epilepsy, and various malformations of cortical development such as agyria, posterior or frontal pachygyria, subcortical band heterotopia, and thin corpus callosum. {ECO:0000269 PubMed:23603762}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for KIF2A Gene

Relevant External Links for KIF2A

Genetic Association Database (GAD)
KIF2A
Human Genome Epidemiology (HuGE) Navigator
KIF2A
genes like me logo Genes that share disorders with KIF2A: view

Publications for KIF2A Gene

  1. Identification of a novel human kinesin-related gene (HK2) by the cDNA differential display technique. (PMID: 9177777) Debernardi S. … Delia D. (Genomics 1997) 2 3 4 23
  2. A family-based association study of kinesin heavy chain member 2 gene (KIF2) and schizophrenia. (PMID: 16959419) Li C. … He L. (Neurosci. Lett. 2006) 3 23 48
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference. (PMID: 15843429) Zhu C. … Jiang W. (Mol. Biol. Cell 2005) 3 4
  5. The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells. (PMID: 17538014) Manning A.L. … Compton D.A. (Mol. Biol. Cell 2007) 3 4

Products for KIF2A Gene

  • Addgene plasmids for KIF2A

Sources for KIF2A Gene

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