Aliases for KIF2A Gene
External Ids for KIF2A Gene
Previous HGNC Symbols for KIF2A Gene
Previous GeneCards Identifiers for KIF2A Gene
The protein encoded by this gene is a plus end-directed motor required for normal mitotic progression. The encoded protein is required for normal spindle activity during mitosis and is necessary for normal brain development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
GeneCards Summary for KIF2A Gene
KIF2A (Kinesin Heavy Chain Member 2A) is a Protein Coding gene. Diseases associated with KIF2A include cortical dysplasia, complex, with other brain malformations 3 and subcortical band heterotopia. Among its related pathways are Reelin Pathway (Cajal-Retzius cells) and Immune System. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF2B.
UniProtKB/Swiss-Prot for KIF2A Gene
Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity.