Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KIF2A Gene

Aliases for KIF2A Gene

  • Kinesin Family Member 2A 2 3 5
  • Kinesin-2 3 4
  • KIF2 3 4
  • HK2 3 4
  • Kinesin Heavy Chain Member 2A 3
  • Kinesin Heavy Chain Member 2 2
  • Kinesin-Like Protein KIF2A 3
  • Kinesin, Heavy Chain, 2 3
  • CDCBM3 3
  • KNS2 4

External Ids for KIF2A Gene

Previous HGNC Symbols for KIF2A Gene

  • KIF2

Previous GeneCards Identifiers for KIF2A Gene

  • GC05P061638
  • GC05P058558
  • GC05P061601

Summaries for KIF2A Gene

Entrez Gene Summary for KIF2A Gene

  • The protein encoded by this gene is a plus end-directed motor required for normal mitotic progression. The encoded protein is required for normal spindle activity during mitosis and is necessary for normal brain development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for KIF2A Gene

KIF2A (Kinesin Family Member 2A) is a Protein Coding gene. Diseases associated with KIF2A include Cortical Dysplasia, Complex, With Other Brain Malformations 3 and Subcortical Band Heterotopia. Among its related pathways are Immune System and Vesicle-mediated transport. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF2B.

UniProtKB/Swiss-Prot for KIF2A Gene

  • Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity.

Gene Wiki entry for KIF2A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF2A Gene

Genomics for KIF2A Gene

Regulatory Elements for KIF2A Gene

Enhancers for KIF2A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F062255 1.1 Ensembl ENCODE 17.9 -49.6 -49553 1.8 HDGF HDAC1 PKNOX1 WRNIP1 ZBTB40 GATA2 ZBTB11 USF2 ZEB2 TBX21 KIF2A DIMT1 PIR57118
GH05F062230 1 Ensembl ENCODE 19 -73.8 -73812 3.5 RFX1 MTA2 NR2F1 JUN KLF17 CEBPB ARID1B MEF2D GATA3 JUND KIF2A PIR39993 RN7SKP157
GH05F062267 0.8 Ensembl ENCODE 17.5 -37.7 -37684 1.1 PKNOX1 MTA2 IKZF1 CEBPB FOS DEK RELA KIF2A PIR57118
GH05F062261 1 ENCODE 11.8 -44.2 -44221 1.1 PKNOX1 ATF1 ARNT CREB3L1 YY1 ELK1 GATA2 ZNF263 NCOA1 KAT8 KIF2A DIMT1 PIR57118
GH05F062402 1.1 ENCODE 10.2 +97.5 97461 2.9 HDGF CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 RNU6-661P KIF2A DIMT1 GC05M062281
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KIF2A on UCSC Golden Path with GeneCards custom track

Promoters for KIF2A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001409921 838 2801 HDGF ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9

Genomic Location for KIF2A Gene

Chromosome:
5
Start:
62,306,162 bp from pter
End:
62,537,249 bp from pter
Size:
231,088 bases
Orientation:
Plus strand

Genomic View for KIF2A Gene

Genes around KIF2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF2A Gene

Proteins for KIF2A Gene

  • Protein details for KIF2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00139-KIF2A_HUMAN
    Recommended name:
    Kinesin-like protein KIF2A
    Protein Accession:
    O00139
    Secondary Accessions:
    • A5YM42
    • A5YM54
    • B4DY54
    • D3DW97
    • E9PB70
    • Q7Z5I3
    • Q8N5Q7

    Protein attributes for KIF2A Gene

    Size:
    706 amino acids
    Molecular mass:
    79955 Da
    Quaternary structure:
    • Interacts with AURKA, PSRC1 and PLK1.
    Miscellaneous:
    • HeLa cells lacking KIF2A show asymmetric or monopolar mitotic spindles. Osteosarcoma cells (U2OS) lacking KIF2A or KIF2B show disorganised or monopolar mitotic spindles.
    SequenceCaution:
    • Sequence=AAP84320.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KIF2A Gene

    Alternative splice isoforms for KIF2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF2A Gene

Post-translational modifications for KIF2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for KIF2A Gene

Domains & Families for KIF2A Gene

Gene Families for KIF2A Gene

Protein Domains for KIF2A Gene

Suggested Antigen Peptide Sequences for KIF2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00139

UniProtKB/Swiss-Prot:

KIF2A_HUMAN :
  • Contains 1 kinesin motor domain.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.
Domain:
  • Contains 1 kinesin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.
genes like me logo Genes that share domains with KIF2A: view

Function for KIF2A Gene

Molecular function for KIF2A Gene

UniProtKB/Swiss-Prot Function:
Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity.

Gene Ontology (GO) - Molecular Function for KIF2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity TAS 9177777
GO:0003777 microtubule motor activity IEA,IBA --
GO:0005515 protein binding IPI 18411309
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
genes like me logo Genes that share ontologies with KIF2A: view
genes like me logo Genes that share phenotypes with KIF2A: view

Human Phenotype Ontology for KIF2A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for KIF2A Gene

MGI Knock Outs for KIF2A:

Animal Model Products

  • Taconic Biosciences Mouse Models for KIF2A

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for KIF2A Gene

Localization for KIF2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF2A Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, spindle. Note=Localized to the spindle microtubules and spindle poles from prophase to metaphase. Efficient targeting to spindle microtubules and spindle poles requires the kinase activity of PLK1. Recruited to mitotic spindles by interaction with PSRC1.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIF2A gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for KIF2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 colocalizes_with spindle pole IEA,IDA 18411309
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
genes like me logo Genes that share ontologies with KIF2A: view

Pathways & Interactions for KIF2A Gene

genes like me logo Genes that share pathways with KIF2A: view

Gene Ontology (GO) - Biological Process for KIF2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS --
GO:0007018 microtubule-based movement IEA,TAS --
GO:0007049 cell cycle IEA --
GO:0007052 mitotic spindle organization IDA 18411309
GO:0007062 sister chromatid cohesion TAS --
genes like me logo Genes that share ontologies with KIF2A: view

No data available for SIGNOR curated interactions for KIF2A Gene

Transcripts for KIF2A Gene

Unigene Clusters for KIF2A Gene

Kinesin heavy chain member 2A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF2A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - -
SP2: -
SP3: -
SP4: - -
SP5: - - - - - - - - - -
SP6:

ExUns: 20a · 20b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for KIF2A Gene

GeneLoc Exon Structure for
KIF2A
ECgene alternative splicing isoforms for
KIF2A

Expression for KIF2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KIF2A Gene

Protein differential expression in normal tissues from HIPED for KIF2A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.0), Breast (14.7), and Platelet (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KIF2A Gene



Protein tissue co-expression partners for KIF2A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KIF2A Gene:

KIF2A

SOURCE GeneReport for Unigene cluster for KIF2A Gene:

Hs.558351
genes like me logo Genes that share expression patterns with KIF2A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KIF2A Gene

Orthologs for KIF2A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KIF2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF2A 34 35
  • 99.48 (n)
oppossum
(Monodelphis domestica)
Mammalia KIF2A 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIF2A 34 35
  • 96.82 (n)
cow
(Bos Taurus)
Mammalia KIF2A 34 35
  • 95.25 (n)
mouse
(Mus musculus)
Mammalia Kif2a 34 16 35
  • 92.06 (n)
rat
(Rattus norvegicus)
Mammalia Kif2a 34
  • 91.73 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KIF2A 35
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIF2A 34 35
  • 87.58 (n)
lizard
(Anolis carolinensis)
Reptilia KIF2A 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kif2a 34
  • 82.46 (n)
Str.20433 34
African clawed frog
(Xenopus laevis)
Amphibia kif2-A-prov 34
zebrafish
(Danio rerio)
Actinopterygii KIF2A 35
  • 85 (a)
OneToOne
zgc:103670 34
  • 74.1 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000159 34
  • 52.5 (n)
fruit fly
(Drosophila melanogaster)
Insecta Klp10A 34 35
  • 50.55 (n)
Klp59C 35
  • 46 (a)
ManyToMany
Klp59D 35
  • 43 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea klp-7 35
  • 41 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.16303 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 53 (a)
OneToMany
Species where no ortholog for KIF2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIF2A Gene

ENSEMBL:
Gene Tree for KIF2A (if available)
TreeFam:
Gene Tree for KIF2A (if available)

Paralogs for KIF2A Gene

Paralogs for KIF2A Gene

(7) SIMAP similar genes for KIF2A Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for KIF2A Gene

genes like me logo Genes that share paralogs with KIF2A: view

Variants for KIF2A Gene

Sequence variations from dbSNP and Humsavar for KIF2A Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs587777033 Cortical dysplasia, complex, with other brain malformations 3 (CDCBM3) [MIM:615411], Pathogenic 62,361,330(+) AAACT(C/G)ATGTA nc-transcript-variant, reference, missense
rs587777034 Cortical dysplasia, complex, with other brain malformations 3 (CDCBM3) [MIM:615411], Pathogenic 62,361,319(+) TGGAA(A/G)TGGAA nc-transcript-variant, reference, missense
rs10044843 -- 62,310,544(+) CATCT(A/G)TGCTC intron-variant
rs10052938 -- 62,384,165(+) ccggg(C/G)caggg intron-variant
rs10062264 -- 62,359,995(+) TTTTT(G/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF2A Gene

Variant ID Type Subtype PubMed ID
dgv5689n100 CNV gain 25217958
dgv5690n100 CNV gain 25217958
esv2759345 CNV gain+loss 17122850
esv35035 CNV gain 17911159
esv3570170 CNV loss 25503493
esv3605230 CNV gain 21293372
esv3605231 CNV gain 21293372
esv3605233 CNV gain 21293372
esv3894198 CNV gain 25118596
nsv1137000 CNV deletion 24896259
nsv1144107 CNV deletion 24896259
nsv598348 CNV gain 21841781
nsv830318 CNV gain 17160897
nsv950071 CNV duplication 24416366

Variation tolerance for KIF2A Gene

Residual Variation Intolerance Score: 25.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.05; 50.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIF2A Gene

Human Gene Mutation Database (HGMD)
KIF2A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIF2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF2A Gene

Disorders for KIF2A Gene

MalaCards: The human disease database

(6) MalaCards diseases for KIF2A Gene - From: OMIM, ClinVar, GeneTests, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
cortical dysplasia, complex, with other brain malformations 3
  • cdcbm3
subcortical band heterotopia
  • subcortical laminar heterotopia
band heterotopia
  • band heterotopia of brain
squamous cell carcinoma of the oral tongue
  • otscc
pachygyria
  • broad gyri of cerebrum
- elite association - COSMIC cancer census association via MalaCards
Search KIF2A in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

KIF2A_HUMAN
  • Cortical dysplasia, complex, with other brain malformations 3 (CDCBM3) [MIM:615411]: A disorder of aberrant neuronal migration and disturbed axonal guidance. Clinical features include early-onset epilepsy, and various malformations of cortical development such as agyria, posterior or frontal pachygyria, subcortical band heterotopia, and thin corpus callosum. {ECO:0000269 PubMed:23603762}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for KIF2A

Genetic Association Database (GAD)
KIF2A
Human Genome Epidemiology (HuGE) Navigator
KIF2A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIF2A
genes like me logo Genes that share disorders with KIF2A: view

No data available for Genatlas for KIF2A Gene

Publications for KIF2A Gene

  1. Identification of a novel human kinesin-related gene (HK2) by the cDNA differential display technique. (PMID: 9177777) Debernardi S. … Delia D. (Genomics 1997) 2 3 4 22 64
  2. A family-based association study of kinesin heavy chain member 2 gene (KIF2) and schizophrenia. (PMID: 16959419) Li C. … He L. (Neurosci. Lett. 2006) 3 22 46 64
  3. Plk1 and Aurora A regulate the depolymerase activity and the cellular localization of Kif2a. (PMID: 19351716) Jang C.Y. … Fang G. (J. Cell Sci. 2009) 3 4 64
  4. DDA3 recruits microtubule depolymerase Kif2a to spindle poles and controls spindle dynamics and mitotic chromosome movement. (PMID: 18411309) Jang C.Y. … Fang G. (J. Cell Biol. 2008) 3 4 64
  5. The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells. (PMID: 17538014) Manning A.L. … Compton D.A. (Mol. Biol. Cell 2007) 3 4 64

Products for KIF2A Gene

Sources for KIF2A Gene

Content
Loading form....