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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KIF27 Gene

protein-coding   GIFtS: 48
GCID: GC09M086451

kinesin family member 27
 Explore 5 diseases affiliated with
KIF27 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KIF27    

Aliases
for KIF27 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Kinesin Family Member 271 2
DKFZp434D09171
Kinesin-Like Protein KIF272

External Ids:    HGNC: 186321   Entrez Gene: 555822   Ensembl: ENSG000001651157   OMIM: 6112535   UniProtKB: Q86VH23   

Export aliases for KIF27 gene to outside databases

Previous GC identifers: GC09M080006 GC09M081908 GC09M083681 GC09M085641 GC09M056276


Summaries
for KIF27 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KIF27:
This gene is a member of the KIF27 (kinesin 4) sub-family of the mammalian kinesin family. The gene is an ortholog of
the Drosophila Cos2 gene, which plays an important role in the Hedgehog signaling pathway. The encoded protein
contains an N-terminal motor domain which includes nucleotide-binding and microtubule-interacting regions, a stalk
domain containing a predicted coiled coil motif and a C-terminal tail domain. Alternatively spliced transcript
variants have been observed for this gene. Pseudogenes associated with this gene are located on chromosome 9.
(provided by RefSeq, Dec 2012)

UniProtKB/Swiss-Prot: KIF27_HUMAN, Q86VH2
Function: Plays an essential role in motile ciliogenesis (By similarity)




Genomic Views
for KIF27 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KIF27 gene promoter:
         GATA-3   Pax-6   GATA-1   YY1   MEF-2A   SRY   Ik-2   FOXO1a   aMEF-2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KIF27 promoter sequence
   Search SABiosciences Chromatin IP Primers for KIF27

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIF27


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21.32   Ensembl cytogenetic band:  9q21.32   HGNC cytogenetic band: 9q21.32

KIF27 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIF27 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M086451:  view genomic region     (about GC identifiers)

Start:
 86,451,613 bp from pter      End:
 86,536,342 bp from pter
Size:
 84,730 bases      Orientation:
 minus strand

Proteins
for KIF27 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KIF27_HUMAN, Q86VH2 (See protein sequence)
Recommended Name: Kinesin-like protein KIF27  
Size: 1401 amino acids; 160283 Da
Subunit: Interacts with STK36 (By similarity)
Subcellular location: Cytoplasm, cytoskeleton (Probable). Cell projection, cilium (By similarity). Note=Localizes to
centrioles and basal bodies (By similarity)
Sequence caution: Sequence=CAB63770.1; Type=Frameshift; Positions=728;
Secondary accessions: B2RTR8 Q5T6W0 Q86VH0 Q86VH1 Q9UF54
Alternative splicing: 4 isoforms:  Q86VH2-1   Q86VH2-2   Q86VH2-3   Q86VH2-4   

Explore the universe of human proteins at neXtProt for KIF27: NX_Q86VH2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86VH2

    • KIF27 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001258856.1  NP_001258857.1  NP_060046.1  

    ENSEMBL proteins: 
     ENSP00000297814   ENSP00000365525   ENSP00000431390   ENSP00000401688   ENSP00000333928  

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    Uscn Proteins for KIF27

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005874microtubule IEA--
    GO:0005875microtubule associated complex IEA--
    GO:0005929cilium ISS--


    KIF27 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for KIF27

    Protein Domains /
    Families
    for KIF27 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KIF27 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001752 Kinesin_motor_dom
     IPR019821 Kinesin_motor_CS

    Graphical View of Domain Structure for InterPro Entry Q86VH2

    ProtoNet protein and cluster: Q86VH2

    1 Blocks protein family: IPB001752 Kinesin

    UniProtKB/Swiss-Prot: KIF27_HUMAN, Q86VH2
    Similarity: Belongs to the kinesin-like protein family. KIF27 subfamily
    Similarity: Contains 1 kinesin-motor domain


    Function
    for KIF27 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KIF27_HUMAN, Q86VH2
    Function: Plays an essential role in motile ciliogenesis (By similarity)

    miRNA
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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003777microtubule motor activity IEA--
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--


    KIF27 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for KIF27:
     Decreased Salmonella enterica   Decreased cilium length after   G0/1 arrest  Increased G1 DNA content 

    Animal Models:
         9 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Kif27):
     cardiovascular system  cellular  craniofacial  growth/size  hearing/vestibular/ear 
     immune system  mortality/aging  nervous system  respiratory system 

    KIF27 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for KIF27 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIF27

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5/557 Interacting proteins for KIF27 (Q86VH22 ENSP000002978144) via UniProtKB, MINT, STRING, and/or I2D (see all 557)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SNW1Q135732, ENSP000002615314MINT-7945693 STRING: ENSP00000261531
    ABCF1Q8NE712MINT-7945693
    ABCF3Q9NUQ82MINT-7945693
    ACIN1Q9UKV32MINT-7945693
    ACTBP607092MINT-7945693
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003351epithelial cilium movement IEA--
    GO:0007018microtubule-based movement ----
    GO:0021591ventricular system development IEA--
    GO:0042384cilium assembly ISS--


    KIF27 for ontologies           About GeneDecksing



    Drugs & Compounds
    for KIF27 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KIF27
    Search CenterWatch for drugs/clinical trials and news about KIF27 

    Transcripts
    for KIF27 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KIF27 gene (3 alternative transcripts): 
    NM_001271927.1  NM_001271928.1  NM_017576.2  

    Unigene Cluster for KIF27:

    Kinesin family member 27
    Hs.697514  [show with all ESTs]
    Unigene Representative Sequence: NM_017576
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000297814(uc004ana.3) ENST00000376347 ENST00000495062 ENST00000413982(uc010mpw.3)
    ENST00000334204(uc010mpx.3)

    miRNA
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    hsa-miR-3671 hsa-miR-3667-3p
    SwitchGear 3'UTR luciferase reporter plasmid: KIF27 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AK297689.1 AL133654.1 AY237536.1 AY237537.1 AY237538.1 BC071819.1 BC140788.1 HM370398.1 

    9 DOTS entries:

    DT.100751450  DT.99955518  DT.100751449  DT.431024  DT.95234901  DT.92045072  DT.121159726  DT.70104036 
    DT.75145837 

    24/26 AceView cDNA sequences (see all 26):

    AY237538 BC071819 AY237536 AW611862 AY237537 NM_017576 AI638203 BX645805 
    AL133654 BU561621 AI621044 AI638192 BU171335 AW135837 BM263504 BV174596 
    AW453084 BE778272 AL602424 AI867880 BM263816 CD709560 BE814664 BG256211 

    GeneLoc Exon Structure


    Expression
    for KIF27 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KIF27 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATTTTTTAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KIF27 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See KIF27 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KIF27

    SOURCE GeneReport for Unigene cluster: Hs.697514

    UniProtKB/Swiss-Prot: KIF27_HUMAN, Q86VH2
    Tissue specificity: Testis, pancreatic islet, germ cell tumors and Jurkat T-cells

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    In Situ
    Assay Products:     
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    Orthologs
    for KIF27 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for KIF27 gene from 2/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves KIF271 kinesin family member 27 68.55(n)
    63.96(a)    		   427456  XM_003643028.1  XP_003643076.1 
    lizard
    (Anolis carolinensis)    		 Reptilia KIF276
    --
    		 --
    		 62(a)
    5(a)
    		 1 ↔ 1
    possible ortholog
    		 2(42614178-42637907)
    5(98775181-98827158)


    ENSEMBL Gene Tree for KIF27 (if available)
    TreeFam Gene Tree for KIF27 (if available) 

    Paralogs
    for KIF27 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KIF27 gene
    KIF5C2  KIF21A2  KIF112  KIF3B2  KIF21B2  KIF92  KIF172  KIF4B2  
    KIF3A2  KIF4A2  KIF5B2  KIF62  KIF152  CENPE2  KIF5A2  KIF72  
    KIF3C2  
    18/22 SIMAP similar genes for KIF27 using alignment to 3 protein entries:     KIF27_HUMAN (see all proteins) (see all similar genes):
    KIF7    KIF21A    KIF5B-ALK    KIF5C    KIF18B    KIF22
    KIF3C    KIF9    KIF3A    CENPE    KIFC3    KIF6
    KIF2C    KIF1A    KIF1C    KIF2A    KIF3B    KIF13A

    KIF27 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for KIF27
    PGOHUM00000236669 PGOHUM00000258396


    Genomic Variants
    for KIF27 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1502 NCBI SNPs in KIF27 are shown (see all 1502)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1827886781,2
    		--86451133(+) CATAAA/CCAGTG 1 -- ds50010--------
    rs1999951451,2
    		--86451230(+) GTAAC-/ATAATGAG 1 -- ds50010--------
    rs1856998221,2
    		--86451302(+) AAACAA/TAAAAG 1 -- ds50010--------
    rs1900109791,2
    		--86451347(+) TCCAGA/GAACAG 1 -- ds50010--------
    rs1823322651,2
    		--86451456(+) CCACAC/TATGCA 1 -- ds50010--------
    rs1874454011,2
    		--86451506(+) TCTTTA/TAAAAA 1 -- ds50010--------
    rs1159928171,2
    		F,--86451515(+) AAAAAA/TATATA 1 -- ds50011Minor allele frequency- T:0.08WA 118
    rs1932760581,2
    		--86451570(+) TTTTAC/TGATGT 1 -- ds50010--------
    rs1836979781,2
    		--86451642(+) CTTCAA/GATATG 1 -- ut310--------
    rs1149067941,2
    		F,--86451667(+) TAAGCG/ATATTT 1 -- ut311Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for KIF27 (86451613 - 86536342 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for KIF27
         5 CNVs: 1828 31519 37818 31520 3773
         1 Inversion: 29497

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    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIF27
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    Disorders / Diseases
    for KIF27 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KIF27 for disorders           About GeneDecksing

    OMIM gene information: 611253    OMIM disorders: --

    5 diseases for KIF27:    About MalaCards
    rubinstein-taybi syndrome    pallister-hall syndrome    germ cell tumor    nephrotic syndrome
    pancreatitis


    Export disorders for KIF27 gene to outside databases

    Publications
    for KIF27 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KIF27 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with KIF27)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs. (PubMed id 12783626)1, 2 Oduru S....Williams S.C. (2003)
    2. Structural insights into human Kif7, a kinesin involve d in Hedgehog signalling. (PubMed id 22281744)1 Klejnot M. and Kozielski F. (2012)
    3. Kinesins and protein kinases: key players in the regul ation of microtubule dynamics and organization. (PubMed id 21345331)1 Daire V. and Pous C. (2011)
    4. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    5. Delineation of the minimal commonly deleted segment and identification of candidate tumor-suppressor genes in del(9q) acute myeloid leukemia. (PubMed id 16015647)1 Sweetser D.A.... Daly S.B. (2005)
    6. KIF27 is one of orthologs for Drosophila Costal-2. (PubMed id 15547729)1 Katoh Y. and Katoh M. (2004)
    7. Characterization of KIF7 gene in silico. (PubMed id 15547730)1 Katoh Y. and Katoh M. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    9. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for KIF27 gene

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    Genome Databases showing KIF27 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55582 HGNC: 18632 AceView: KIF27 Ensembl:ENSG00000165115 euGenes: HUgn55582
    ECgene: KIF27 H-InvDB: KIF27

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    Specialized Databases showing KIF27 gene

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    PharmGKB entry for KIF27 Pharmacogenomics, SNPs, Pathways

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