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Aliases for KIF27 Gene

Aliases for KIF27 Gene

  • Kinesin Family Member 27 2 3

External Ids for KIF27 Gene

Previous GeneCards Identifiers for KIF27 Gene

  • GC09M080006
  • GC09M081908
  • GC09M083681
  • GC09M085641
  • GC09M086451
  • GC09M056276

Summaries for KIF27 Gene

Entrez Gene Summary for KIF27 Gene

  • This gene is a member of the KIF27 (kinesin 4) sub-family of the mammalian kinesin family. The gene is an ortholog of the Drosophila Cos2 gene, which plays an important role in the Hedgehog signaling pathway. The encoded protein contains an N-terminal motor domain which includes nucleotide-binding and microtubule-interacting regions, a stalk domain containing a predicted coiled coil motif and a C-terminal tail domain. Alternatively spliced transcript variants have been observed for this gene. Pseudogenes associated with this gene are located on chromosome 9. [provided by RefSeq, Dec 2012]

GeneCards Summary for KIF27 Gene

KIF27 (Kinesin Family Member 27) is a Protein Coding gene. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF5C.

UniProtKB/Swiss-Prot for KIF27 Gene

  • Plays an essential role in motile ciliogenesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF27 Gene

Genomics for KIF27 Gene

Regulatory Elements for KIF27 Gene

Genomic Location for KIF27 Gene

83,836,698 bp from pter
83,921,467 bp from pter
84,770 bases
Minus strand

Genomic View for KIF27 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIF27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF27 Gene

Proteins for KIF27 Gene

  • Protein details for KIF27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kinesin-like protein KIF27
    Protein Accession:
    Secondary Accessions:
    • B2RTR8
    • Q5T6W0
    • Q86VH0
    • Q86VH1
    • Q9UF54

    Protein attributes for KIF27 Gene

    1401 amino acids
    Molecular mass:
    160283 Da
    Quaternary structure:
    • Interacts with STK36.
    • Sequence=CAB63770.1; Type=Frameshift; Positions=728; Evidence={ECO:0000305};

    Alternative splice isoforms for KIF27 Gene


neXtProt entry for KIF27 Gene

Proteomics data for KIF27 Gene at MOPED

Post-translational modifications for KIF27 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIF27 Gene

No data available for DME Specific Peptides for KIF27 Gene

Domains & Families for KIF27 Gene

Gene Families for KIF27 Gene

Protein Domains for KIF27 Gene

Suggested Antigen Peptide Sequences for KIF27 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 kinesin motor domain.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF27 subfamily.
  • Contains 1 kinesin motor domain.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF27 subfamily.
genes like me logo Genes that share domains with KIF27: view

Function for KIF27 Gene

Molecular function for KIF27 Gene

UniProtKB/Swiss-Prot Function:
Plays an essential role in motile ciliogenesis.

Gene Ontology (GO) - Molecular Function for KIF27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity IBA --
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
GO:0016887 ATPase activity IBA --
genes like me logo Genes that share ontologies with KIF27: view
genes like me logo Genes that share phenotypes with KIF27: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for KIF27 Gene

Localization for KIF27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF27 Gene

Cytoplasm, cytoskeleton. Cell projection, cilium. Note=Localizes to centrioles and basal bodies. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for KIF27 Gene COMPARTMENTS Subcellular localization image for KIF27 gene
Compartment Confidence
extracellular 5
cytoskeleton 3

Gene Ontology (GO) - Cellular Components for KIF27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005871 kinesin complex IBA --
GO:0005874 microtubule IEA --
GO:0005929 cilium ISS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with KIF27: view

Pathways & Interactions for KIF27 Gene

SuperPathways for KIF27 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KIF27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003351 epithelial cilium movement IEA --
GO:0007018 microtubule-based movement IBA --
GO:0007224 smoothened signaling pathway IBA --
GO:0008152 metabolic process IEA --
GO:0021591 ventricular system development IBA --
genes like me logo Genes that share ontologies with KIF27: view

No data available for Pathways by source and SIGNOR curated interactions for KIF27 Gene

Drugs & Compounds for KIF27 Gene

No Compound Related Data Available

Transcripts for KIF27 Gene

Unigene Clusters for KIF27 Gene

Kinesin family member 27:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIF27

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF27 Gene

No ASD Table

Relevant External Links for KIF27 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KIF27 Gene

mRNA expression in normal human tissues for KIF27 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIF27 Gene

This gene is overexpressed in Testis (x6.5).

Protein differential expression in normal tissues from HIPED for KIF27 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (46.3) and Brain (17.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIF27 Gene

SOURCE GeneReport for Unigene cluster for KIF27 Gene Hs.697514

mRNA Expression by UniProt/SwissProt for KIF27 Gene

Tissue specificity: Testis, pancreatic islet, germ cell tumors and Jurkat T-cells
genes like me logo Genes that share expression patterns with KIF27: view

Protein tissue co-expression partners for KIF27 Gene

Primer Products

In Situ Assay Products

Orthologs for KIF27 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KIF27 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KIF27 35
  • 90.18 (n)
  • 87.38 (a)
KIF27 36
  • 87 (a)
(Canis familiaris)
Mammalia KIF27 35
  • 88.83 (n)
  • 86.25 (a)
KIF27 36
  • 86 (a)
(Mus musculus)
Mammalia Kif27 35
  • 81.31 (n)
  • 79.27 (a)
Kif27 16
Kif27 36
  • 79 (a)
(Pan troglodytes)
Mammalia KIF27 35
  • 99.5 (n)
  • 98.93 (a)
KIF27 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Kif27 35
  • 80.66 (n)
  • 78.69 (a)
(Monodelphis domestica)
Mammalia KIF27 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia KIF27 36
  • 45 (a)
(Gallus gallus)
Aves KIF27 35
  • 68.29 (n)
  • 63.72 (a)
KIF27 36
  • 63 (a)
(Anolis carolinensis)
Reptilia KIF27 36
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kif27 35
  • 61.04 (n)
  • 60.38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CIN8 36
  • 20 (a)
Species with no ortholog for KIF27:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KIF27 Gene

Gene Tree for KIF27 (if available)
Gene Tree for KIF27 (if available)

Paralogs for KIF27 Gene Pseudogenes for KIF27 Gene

genes like me logo Genes that share paralogs with KIF27: view

Variants for KIF27 Gene

Sequence variations from dbSNP and Humsavar for KIF27 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs963459 -- 83,892,527(+) ACAGA(C/G)GAGGA intron-variant, upstream-variant-2KB
rs970846 -- 83,913,851(+) CATCA(A/T)ACTTA intron-variant
rs1034187 -- 83,899,292(+) TAAGA(A/G)GATAA intron-variant
rs1058995 -- 83,867,838(+) CTAAC(C/T)ATTTC stop-gained, reference, intron-variant, nc-transcript-variant
rs1412900 -- 83,907,818(+) AGGAA(A/G)AAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF27 Gene

Variant ID Type Subtype PubMed ID
nsv469859 CNV Complex 16826518
dgv2394e1 CNV Complex 17122850
nsv6590 CNV Loss 18451855
nsv8540 CNV Gain 18304495
nsv6591 CNV Insertion 18451855
esv1179518 CNV Insertion 17803354
nsv8541 CNV Gain 18304495
nsv438108 CNV Loss 16468122
nsv436717 OTHER Inversion 17901297
nsv442559 CNV CNV 18776908
nsv831644 CNV Gain 17160897
esv2738669 CNV Deletion 23290073

Variation tolerance for KIF27 Gene

Residual Variation Intolerance Score: 78.89% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.12; 93.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIF27 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF27 Gene

Disorders for KIF27 Gene

Relevant External Links for KIF27

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with KIF27: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIF27 Gene

Publications for KIF27 Gene

  1. [Comparison of urinary proteomics between steroid-sensitive and steroid-resistant minimal change nephrotic syndrome in children]. (PMID: 17959526) Huang Y.J. … Chen R.H. (Nan Fang Yi Ke Da Xue Xue Bao 2007) 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 67
  4. Structural insights into human Kif7, a kinesin involved in Hedgehog signalling. (PMID: 22281744) Klejnot M. … Kozielski F. (Acta Crystallogr. D Biol. Crystallogr. 2012) 67
  5. Kinesins and protein kinases: key players in the regulation of microtubule dynamics and organization. (PMID: 21345331) Daire V. … PoA1s C. (Arch. Biochem. Biophys. 2011) 67

Products for KIF27 Gene

Sources for KIF27 Gene

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