Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KIF26B Gene

Aliases for KIF26B Gene

  • Kinesin Family Member 26B 2 3 5

External Ids for KIF26B Gene

Previous GeneCards Identifiers for KIF26B Gene

  • GC01P243384
  • GC01P245318
  • GC01P215701

Summaries for KIF26B Gene

GeneCards Summary for KIF26B Gene

KIF26B (Kinesin Family Member 26B) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Factors involved in megakaryocyte development and platelet production. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF26A.

UniProtKB/Swiss-Prot for KIF26B Gene

  • Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF26B Gene

Genomics for KIF26B Gene

Regulatory Elements for KIF26B Gene

Enhancers for KIF26B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F245298 0.2 ENCODE 15.5 +144.0 144007 0.6 KIF26B PIR44116 DNAJC19P8
GH01F245177 0.6 ENCODE 11.9 +22.2 22249 0.2 JUND ZNF366 FOS SP7 TCF7L2 KIF26B ENSG00000232192
GH01F245178 0.2 ENCODE 11.9 +22.5 22509 0.2 ZNF366 SP7 TCF7L2 KIF26B ENSG00000232192
GH01F245180 1 Ensembl ENCODE 11.9 +25.8 25816 0.4 YBX3 ZNF512 ZMYM3 MLLT1 TRIM24 NFXL1 ZNF24 KIF26B ENSG00000232192
GH01F245188 0.2 Ensembl 11.8 +33.6 33616 0.8 ZNF316 KIF26B ENSG00000232192
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around KIF26B on UCSC Golden Path with GeneCards custom track

Promoters for KIF26B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000556366 216 4400 CBX3 INSM2 SIN3A RAD21 GLIS2 ZNF143 CREM MIXL1 ZNF263 HMG20B

Genomic Location for KIF26B Gene

Chromosome:
1
Start:
245,154,985 bp from pter
End:
245,709,432 bp from pter
Size:
554,448 bases
Orientation:
Plus strand

Genomic View for KIF26B Gene

Genes around KIF26B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF26B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF26B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF26B Gene

Proteins for KIF26B Gene

  • Protein details for KIF26B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2KJY2-KI26B_HUMAN
    Recommended name:
    Kinesin-like protein KIF26B
    Protein Accession:
    Q2KJY2
    Secondary Accessions:
    • Q6ZQR9
    • Q6ZUZ0
    • Q8IUN3
    • Q8IVR1
    • Q9NWB4

    Protein attributes for KIF26B Gene

    Size:
    2108 amino acids
    Molecular mass:
    223883 Da
    Quaternary structure:
    • Interacts with MYH10.
    SequenceCaution:
    • Sequence=AAH42481.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=BAA91469.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC86076.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=BAC87614.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for KIF26B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF26B Gene

Post-translational modifications for KIF26B Gene

  • Phosphorylation at Thr-1855 and Ser-1958 by CDKs, mainly CDK2 and CDK5, enhances the interaction with NEDD4, polyubiquitination, and subsequent proteasomal degradation. Phosphorylation occurs upon loss of interaction with microtubules (By similarity).
  • Polyubiquitinated by NEDD4, resulting in proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIF26B Gene

No data available for DME Specific Peptides for KIF26B Gene

Domains & Families for KIF26B Gene

Gene Families for KIF26B Gene

Protein Domains for KIF26B Gene

Suggested Antigen Peptide Sequences for KIF26B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2KJY2

UniProtKB/Swiss-Prot:

KI26B_HUMAN :
  • Contains 1 kinesin motor domain.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF26 subfamily.
Domain:
  • Contains 1 kinesin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF26 subfamily.
genes like me logo Genes that share domains with KIF26B: view

Function for KIF26B Gene

Molecular function for KIF26B Gene

UniProtKB/Swiss-Prot Function:
Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity).

Gene Ontology (GO) - Molecular Function for KIF26B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity IEA --
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed IBA --
genes like me logo Genes that share ontologies with KIF26B: view
genes like me logo Genes that share phenotypes with KIF26B: view

Animal Models for KIF26B Gene

MGI Knock Outs for KIF26B:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KIF26B Gene

Localization for KIF26B Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF26B Gene

Cytoplasm. Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIF26B Gene COMPARTMENTS Subcellular localization image for KIF26B gene
Compartment Confidence
cytoskeleton 4
plasma membrane 3
nucleus 2
cytosol 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KIF26B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005871 kinesin complex IBA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with KIF26B: view

Pathways & Interactions for KIF26B Gene

genes like me logo Genes that share pathways with KIF26B: view

Gene Ontology (GO) - Biological Process for KIF26B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007018 NOT microtubule-based movement IEA,IBA --
GO:0007275 multicellular organism development IEA --
GO:0007411 axon guidance IBA --
GO:0008104 protein localization IBA --
GO:0022409 positive regulation of cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with KIF26B: view

No data available for SIGNOR curated interactions for KIF26B Gene

Transcripts for KIF26B Gene

mRNA/cDNA for KIF26B Gene

(3) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KIF26B Gene

Kinesin family member 26B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF26B Gene

No ASD Table

Relevant External Links for KIF26B Gene

GeneLoc Exon Structure for
KIF26B
ECgene alternative splicing isoforms for
KIF26B

Expression for KIF26B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KIF26B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIF26B Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.1).

Protein differential expression in normal tissues from HIPED for KIF26B Gene

This gene is overexpressed in Liver (38.0), Adipocyte (11.7), Monocytes (7.4), and Retina (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KIF26B Gene



Protein tissue co-expression partners for KIF26B Gene

NURSA nuclear receptor signaling pathways regulating expression of KIF26B Gene:

KIF26B

SOURCE GeneReport for Unigene cluster for KIF26B Gene:

Hs.368096
genes like me logo Genes that share expression patterns with KIF26B: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for KIF26B Gene

Orthologs for KIF26B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KIF26B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF26B 34 35
  • 98.72 (n)
cow
(Bos Taurus)
Mammalia KIF26B 34 35
  • 88 (n)
dog
(Canis familiaris)
Mammalia KIF26B 34 35
  • 86.87 (n)
rat
(Rattus norvegicus)
Mammalia Kif26b 34
  • 84.9 (n)
mouse
(Mus musculus)
Mammalia Kif26b 34 16 35
  • 84.89 (n)
oppossum
(Monodelphis domestica)
Mammalia KIF26B 35
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF26B 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIF26B 34 35
  • 75.29 (n)
lizard
(Anolis carolinensis)
Reptilia KIF26B 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kif26b 34
  • 67.56 (n)
zebrafish
(Danio rerio)
Actinopterygii kif26ba 34 35
  • 63.72 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14535 35
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea vab-8 35
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SMY1 35
  • 23 (a)
OneToMany
Species where no ortholog for KIF26B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIF26B Gene

ENSEMBL:
Gene Tree for KIF26B (if available)
TreeFam:
Gene Tree for KIF26B (if available)

Paralogs for KIF26B Gene

Paralogs for KIF26B Gene

(1) SIMAP similar genes for KIF26B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KIF26B: view

Variants for KIF26B Gene

Sequence variations from dbSNP and Humsavar for KIF26B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10082158 -- 245,385,909(+) TGGAT(A/G)TGGGA intron-variant
rs1010508 -- 245,169,662(-) TGCCT(C/G)ATTGG intron-variant
rs1010509 -- 245,167,079(+) TCAAT(A/C)CTGTT intron-variant
rs1010510 -- 245,167,174(+) TTTCT(C/T)TTTAT intron-variant
rs10157129 -- 245,549,738(+) CCTCA(C/T)TGAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF26B Gene

Variant ID Type Subtype PubMed ID
dgv113n67 CNV loss 20364138
dgv161e212 CNV loss 25503493
dgv162e212 CNV loss 25503493
dgv315n106 CNV deletion 24896259
dgv326e59 CNV duplication 20981092
dgv59e201 CNV deletion 23290073
dgv602n100 CNV gain 25217958
dgv62n27 CNV loss 19166990
dgv882n54 CNV loss 21841781
dgv883n54 CNV loss 21841781
dgv884n54 CNV loss 21841781
dgv885n54 CNV loss 21841781
esv1010286 CNV insertion 20482838
esv1330272 CNV deletion 17803354
esv1366991 CNV deletion 17803354
esv1457319 CNV deletion 17803354
esv1635429 CNV deletion 17803354
esv1719464 CNV deletion 17803354
esv1751553 CNV insertion 17803354
esv1756438 CNV deletion 17803354
esv1770455 CNV deletion 17803354
esv1786816 CNV insertion 17803354
esv1964314 CNV deletion 18987734
esv2112759 CNV deletion 18987734
esv22570 CNV loss 19812545
esv2275975 CNV deletion 18987734
esv2374353 CNV deletion 18987734
esv2421654 CNV deletion 20811451
esv2606381 CNV deletion 19546169
esv2636493 CNV insertion 19546169
esv2659202 CNV deletion 23128226
esv2662066 CNV deletion 23128226
esv2673051 CNV deletion 23128226
esv2676437 CNV deletion 23128226
esv2677310 CNV deletion 23128226
esv2726773 CNV deletion 23290073
esv2726784 CNV deletion 23290073
esv2726795 CNV deletion 23290073
esv2726807 CNV deletion 23290073
esv2726818 CNV deletion 23290073
esv2726829 CNV deletion 23290073
esv2726840 CNV deletion 23290073
esv2726851 CNV deletion 23290073
esv2726862 CNV deletion 23290073
esv2726873 CNV deletion 23290073
esv2726884 CNV deletion 23290073
esv2726906 CNV deletion 23290073
esv2726929 CNV deletion 23290073
esv2726940 CNV deletion 23290073
esv2726951 CNV deletion 23290073
esv2726962 CNV deletion 23290073
esv2726973 CNV deletion 23290073
esv2726984 CNV deletion 23290073
esv2726995 CNV deletion 23290073
esv2727006 CNV deletion 23290073
esv2727017 CNV deletion 23290073
esv2727029 CNV deletion 23290073
esv2727040 CNV deletion 23290073
esv2727051 CNV deletion 23290073
esv2763758 CNV loss 21179565
esv28270 CNV gain 19812545
esv29096 CNV loss 19812545
esv3337403 CNV insertion 20981092
esv33776 CNV loss 17666407
esv3430624 CNV duplication 20981092
esv3549888 CNV deletion 23714750
esv3549900 CNV deletion 23714750
esv3549922 CNV deletion 23714750
esv3549955 CNV deletion 23714750
esv3575839 CNV gain 25503493
esv3589431 CNV loss 21293372
esv3589432 CNV loss 21293372
esv3589433 CNV loss 21293372
esv3589434 CNV loss 21293372
esv3589435 CNV loss 21293372
esv3589436 CNV loss 21293372
esv3589437 CNV loss 21293372
esv3589438 CNV loss 21293372
esv3589439 CNV loss 21293372
esv3589440 CNV loss 21293372
esv3589441 CNV loss 21293372
esv3589442 CNV loss 21293372
esv3589443 CNV loss 21293372
esv3589444 CNV loss 21293372
esv3589446 CNV loss 21293372
esv3891304 CNV loss 25118596
esv3891315 CNV loss 25118596
esv4377 CNV loss 18987735
esv4958 CNV loss 18987735
esv994414 CNV deletion 20482838
esv999717 CNV deletion 20482838
nsv1001831 CNV loss 25217958
nsv1002555 CNV loss 25217958
nsv1010191 CNV loss 25217958
nsv1011796 CNV gain 25217958
nsv1015005 CNV loss 25217958
nsv1068644 CNV deletion 25765185
nsv1069428 CNV deletion 25765185
nsv1120205 CNV tandem duplication 24896259
nsv1120629 CNV deletion 24896259
nsv1121084 CNV deletion 24896259
nsv1145417 CNV deletion 24896259
nsv1147088 CNV deletion 26484159
nsv1148568 CNV deletion 26484159
nsv1160480 CNV deletion 26073780
nsv1160481 CNV deletion 26073780
nsv161160 CNV deletion 16902084
nsv441744 CNV loss 18776908
nsv441745 CNV loss 18776908
nsv468761 CNV loss 19166990
nsv468783 CNV loss 19166990
nsv470791 CNV loss 18288195
nsv472200 CNV novel sequence insertion 20440878
nsv472353 CNV novel sequence insertion 20440878
nsv474177 CNV novel sequence insertion 20440878
nsv475886 CNV novel sequence insertion 20440878
nsv477195 CNV novel sequence insertion 20440878
nsv479117 CNV novel sequence insertion 20440878
nsv479136 CNV novel sequence insertion 20440878
nsv480246 CNV novel sequence insertion 20440878
nsv480417 CNV novel sequence insertion 20440878
nsv480549 CNV novel sequence insertion 20440878
nsv508704 CNV deletion 20534489
nsv509735 CNV insertion 20534489
nsv515634 CNV loss 19592680
nsv517138 CNV loss 19592680
nsv517322 CNV loss 19592680
nsv517510 CNV loss 19592680
nsv5199 CNV insertion 18451855
nsv5210 CNV insertion 18451855
nsv521141 CNV loss 19592680
nsv5221 CNV insertion 18451855
nsv522286 CNV gain 19592680
nsv5232 CNV insertion 18451855
nsv524642 CNV loss 19592680
nsv527082 CNV loss 19592680
nsv528375 CNV loss 19592680
nsv549494 CNV gain 21841781
nsv549495 CNV loss 21841781
nsv549496 CNV gain 21841781
nsv549511 CNV loss 21841781
nsv549512 CNV loss 21841781
nsv549519 CNV loss 21841781
nsv7191 OTHER inversion 18451855
nsv818877 CNV loss 17921354
nsv827698 CNV gain 20364138
nsv954011 CNV deletion 24416366
nsv956618 CNV deletion 24416366

Variation tolerance for KIF26B Gene

Residual Variation Intolerance Score: 94.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.93; 79.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIF26B Gene

Human Gene Mutation Database (HGMD)
KIF26B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIF26B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF26B Gene

Disorders for KIF26B Gene

Relevant External Links for KIF26B

Genetic Association Database (GAD)
KIF26B
Human Genome Epidemiology (HuGE) Navigator
KIF26B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIF26B

No disorders were found for KIF26B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIF26B Gene

Publications for KIF26B Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. MxA interacts with and is modified by the SUMOylation machinery. (PMID: 25447205) Brantis-de-Carvalho C.E. … Valentini S.R. (Exp. Cell Res. 2015) 3 64
  4. Elevated kinesin family member 26B is a prognostic biomarker and a potential therapeutic target for colorectal cancer. (PMID: 25652119) Wang J. … Peng Z. (J. Exp. Clin. Cancer Res. 2015) 3 64
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64

Products for KIF26B Gene

Sources for KIF26B Gene

Content
Loading form....