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Aliases for KIF26B Gene

Aliases for KIF26B Gene

  • Kinesin Family Member 26B 2 3

External Ids for KIF26B Gene

Previous GeneCards Identifiers for KIF26B Gene

  • GC01P243384
  • GC01P245318
  • GC01P215701

Summaries for KIF26B Gene

GeneCards Summary for KIF26B Gene

KIF26B (Kinesin Family Member 26B) is a Protein Coding gene. GO annotations related to this gene include microtubule binding and microtubule motor activity. An important paralog of this gene is KIF26A.

UniProtKB/Swiss-Prot for KIF26B Gene

  • Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF26B Gene

Genomics for KIF26B Gene

Regulatory Elements for KIF26B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KIF26B Gene

Start:
245,154,985 bp from pter
End:
245,709,431 bp from pter
Size:
554,447 bases
Orientation:
Plus strand

Genomic View for KIF26B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIF26B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF26B Gene

Proteins for KIF26B Gene

  • Protein details for KIF26B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2KJY2-KI26B_HUMAN
    Recommended name:
    Kinesin-like protein KIF26B
    Protein Accession:
    Q2KJY2
    Secondary Accessions:
    • Q6ZQR9
    • Q6ZUZ0
    • Q8IUN3
    • Q8IVR1
    • Q9NWB4

    Protein attributes for KIF26B Gene

    Size:
    2108 amino acids
    Molecular mass:
    223883 Da
    Quaternary structure:
    • Interacts with MYH10.
    SequenceCaution:
    • Sequence=AAH42481.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=BAA91469.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC86076.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=BAC87614.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for KIF26B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF26B Gene

Proteomics data for KIF26B Gene at MOPED

Post-translational modifications for KIF26B Gene

  • Phosphorylation at Thr-1855 and Ser-1958 by CDKs, mainly CDK2 and CDK5, enhances the interaction with NEDD4, polyubiquitination, and subsequent proteasomal degradation. Phosphorylation occurs upon loss of interaction with microtubules (By similarity).
  • Polyubiquitinated by NEDD4, resulting in proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIF26B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KIF26B Gene

Domains for KIF26B Gene

Gene Families for KIF26B Gene

HGNC:
  • KIF :Kinesins

Protein Domains for KIF26B Gene

Suggested Antigen Peptide Sequences for KIF26B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2KJY2

UniProtKB/Swiss-Prot:

KI26B_HUMAN :
  • Q2KJY2
Domain:
  • Contains 1 kinesin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF26 subfamily.
genes like me logo Genes that share domains with KIF26B: view

Function for KIF26B Gene

Molecular function for KIF26B Gene

UniProtKB/Swiss-Prot Function: Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity).

Gene Ontology (GO) - Molecular Function for KIF26B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity IBA --
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
GO:0016887 NOT ATPase activity IBA --
genes like me logo Genes that share ontologies with KIF26B: view

Phenotypes for KIF26B Gene

genes like me logo Genes that share phenotypes with KIF26B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIF26B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KIF26B Gene

Localization for KIF26B Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF26B Gene

Cytoplasm. Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIF26B Gene COMPARTMENTS Subcellular localization image for KIF26B gene
Compartment Confidence
cytoskeleton 4
nucleus 2
cytosol 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for KIF26B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005871 kinesin complex IBA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with KIF26B: view

Pathways for KIF26B Gene

SuperPathways for KIF26B Gene

No Data Available

Gene Ontology (GO) - Biological Process for KIF26B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007018 NOT microtubule-based movement IBA --
GO:0008152 metabolic process IEA --
GO:0022409 positive regulation of cell-cell adhesion IEA --
GO:0030010 establishment of cell polarity IEA --
GO:0072092 ureteric bud invasion IEA --
genes like me logo Genes that share ontologies with KIF26B: view

No data available for Pathways by source for KIF26B Gene

Transcripts for KIF26B Gene

mRNA/cDNA for KIF26B Gene

(8) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(6) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KIF26B Gene

Kinesin family member 26B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIF26B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF26B Gene

No ASD Table

Relevant External Links for KIF26B Gene

GeneLoc Exon Structure for
KIF26B
ECgene alternative splicing isoforms for
KIF26B

Expression for KIF26B Gene

mRNA expression in normal human tissues for KIF26B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIF26B Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIF26B Gene

SOURCE GeneReport for Unigene cluster for KIF26B Gene Hs.368096

genes like me logo Genes that share expressions with KIF26B: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for KIF26B Gene

Orthologs for KIF26B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KIF26B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF26B 35
  • 98.72 (n)
  • 97.91 (a)
KIF26B 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIF26B 35
  • 88 (n)
  • 90.26 (a)
KIF26B 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIF26B 35
  • 86.87 (n)
  • 87.99 (a)
KIF26B 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kif26b 35
  • 84.89 (n)
  • 88.5 (a)
Kif26b 16
Kif26b 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIF26B 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF26B 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kif26b 35
  • 84.9 (n)
  • 87.63 (a)
chicken
(Gallus gallus)
Aves KIF26B 35
  • 75.29 (n)
  • 80.46 (a)
KIF26B 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIF26B 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kif26b 35
  • 67.56 (n)
  • 75.23 (a)
zebrafish
(Danio rerio)
Actinopterygii kif26ba 35
  • 63.72 (n)
  • 66.88 (a)
kif26ba 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14535 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea vab-8 36
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SMY1 36
  • 23 (a)
OneToMany
Species with no ortholog for KIF26B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIF26B Gene

ENSEMBL:
Gene Tree for KIF26B (if available)
TreeFam:
Gene Tree for KIF26B (if available)

Paralogs for KIF26B Gene

Paralogs for KIF26B Gene

Selected SIMAP similar genes for KIF26B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KIF26B: view

Variants for KIF26B Gene

Sequence variations from dbSNP and Humsavar for KIF26B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs170932 -- 245,398,572(+) TCATA(G/T)CCAGT intron-variant
rs180224 -- 245,435,780(+) CCCTA(G/T)GTCCG intron-variant
rs184622 -- 245,327,364(+) GCATA(G/T)AATAA intron-variant
rs186829 -- 245,313,596(+) AGCGG(G/T)CAAAA intron-variant
rs186830 -- 245,366,576(+) GCGAA(A/G)AAGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF26B Gene

Variant ID Type Subtype PubMed ID
nsv873395 CNV Gain 21882294
nsv515634 CNV Loss 19592680
nsv524642 CNV Loss 19592680
nsv528375 CNV Loss 19592680
esv2677310 CNV Deletion 23128226
nsv5199 CNV Insertion 18451855
dgv557n71 CNV Gain 21882294
esv2726773 CNV Deletion 23290073
esv1964314 CNV Deletion 18987734
esv4377 CNV Deletion 18987735
esv2726784 CNV Deletion 23290073
esv1366991 CNV Deletion 17803354
esv2421654 CNV Deletion 20811451
nsv441744 CNV CNV 18776908
dgv113n67 CNV Loss 20364138
nsv527082 CNV Loss 19592680
esv2726795 CNV Deletion 23290073
esv2662066 CNV Deletion 23128226
esv2726807 CNV Deletion 23290073
nsv5210 CNV Insertion 18451855
nsv873398 CNV Gain 21882294
esv28270 CNV Gain 19812545
nsv7191 OTHER Inversion 18451855
esv29096 CNV Loss 19812545
nsv161160 CNV Loss 16902084
esv2726818 CNV Deletion 23290073
esv1635429 CNV Deletion 17803354
esv2606381 CNV Deletion 19546169
esv2726829 CNV Deletion 23290073
esv1457319 CNV Deletion 17803354
esv1330272 CNV Deletion 17803354
esv1756438 CNV Deletion 17803354
nsv873399 CNV Gain 21882294
nsv873400 CNV Gain 21882294
dgv62n27 CNV Loss 19166990
dgv558n71 CNV Loss 21882294
esv2673051 CNV Deletion 23128226
esv2726840 CNV Deletion 23290073
esv22570 CNV Loss 19812545
nsv517322 CNV Loss 19592680
nsv818877 CNV Loss 17921354
nsv468761 CNV Loss 19166990
nsv470791 CNV Loss 18288195
nsv441745 CNV CNV 18776908
nsv508704 CNV Loss 20534489
nsv468783 CNV Loss 19166990
nsv517138 CNV Loss 19592680
esv33776 CNV Loss 17666407
esv2726851 CNV Deletion 23290073
esv2659202 CNV Deletion 23128226
nsv522286 CNV Gain 19592680
esv2374353 CNV Deletion 18987734
esv2726862 CNV Deletion 23290073
nsv873403 CNV Loss 21882294
nsv5221 CNV Insertion 18451855
esv2636493 CNV Insertion 19546169
esv1751553 CNV Insertion 17803354
esv2676437 CNV Deletion 23128226
esv2726873 CNV Deletion 23290073
esv2275975 CNV Deletion 18987734
esv4958 CNV Deletion 18987735
esv2726884 CNV Deletion 23290073
esv994414 CNV Deletion 20482838
esv1719464 CNV Deletion 17803354
dgv71e201 CNV Deletion 23290073
esv2726906 CNV Deletion 23290073
nsv509735 CNV Insertion 20534489
nsv521141 CNV Loss 19592680
esv1786816 CNV Insertion 17803354
esv1010286 CNV Insertion 20482838
esv2726929 CNV Deletion 23290073
esv2726940 CNV Deletion 23290073
esv2726951 CNV Deletion 23290073
nsv5232 CNV Insertion 18451855
esv2726962 CNV Deletion 23290073
esv2726973 CNV Deletion 23290073
esv2726984 CNV Deletion 23290073
esv2726995 CNV Deletion 23290073
esv2727006 CNV Deletion 23290073
nsv517510 CNV Loss 19592680
nsv827698 CNV Gain 20364138
nsv873404 CNV Gain 21882294
esv2727017 CNV Deletion 23290073
esv2727029 CNV Deletion 23290073
esv2727040 CNV Deletion 23290073
esv2112759 CNV Deletion 18987734
esv999717 CNV Deletion 20482838
esv2727051 CNV Deletion 23290073
esv1770455 CNV Deletion 17803354

Relevant External Links for KIF26B Gene

HapMap Linkage Disequilibrium report
KIF26B
Human Gene Mutation Database (HGMD)
KIF26B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF26B Gene

Disorders for KIF26B Gene

(1) University of Copenhagen DISEASES for KIF26B Gene

Relevant External Links for KIF26B

Genetic Association Database (GAD)
KIF26B
Human Genome Epidemiology (HuGE) Navigator
KIF26B
genes like me logo Genes that share disorders with KIF26B: view

No data available for UniProtKB/Swiss-Prot for KIF26B Gene

Publications for KIF26B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. A human MAP kinase interactome. (PMID: 20936779) Bandyopadhyay S. … Ideker T. (Nat. Methods 2010) 3
  4. Phosphorylation of Kif26b promotes its polyubiquitination and subsequent proteasomal degradation during kidney development. (PMID: 22768111) Terabayashi T. … Nishinakamura R. (PLoS ONE 2012) 3
  5. Genome-wide association study of clinical dimensions of schizophrenia: polygenic effect on disorganized symptoms. (PMID: 23212062) Fanous A.H. … Levinson D.F. (Am J Psychiatry 2012) 3

Products for KIF26B Gene

Sources for KIF26B Gene

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