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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KIF26B Gene

protein-coding   GIFtS: 45
GCID: GC01P245318

kinesin family member 26B

 Explore 2 diseases affiliated with
KIF26B via our new
 Human Malady Compendium 
Biological research products
for KIF26B
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Kinesin Family Member 26B1 2
FLJ101571
Kinesin-Like Protein KIF26B2

External Ids:    HGNC: 254841   Entrez Gene: 550832   Ensembl: ENSG000001628497   OMIM: 6140265   UniProtKB: Q2KJY23   

Export aliases for KIF26B gene to outside databases

Previous GC identifers: GC01P243384 GC01P215701


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: KI26B_HUMAN, Q2KJY2
Function: Essential for embryonic kidney development. Plays an important role in the compact adhesion between
mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the
establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains
the GDNF expression required for further ureteric bud attraction (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KIF26B gene promoter:
         HFH-3   LHX3b/Lhx3b   RREB-1   Olf-1   FOXI1   MZF-1   S8   SRY   LHX3a/Lhx3a   Hlf   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for KIF26B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIF26B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q44   Ensembl cytogenetic band:  1q44   HGNC cytogenetic band: 1q44

KIF26B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIF26B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P245318:  view genomic region     (about GC identifiers)

Start:
245,318,287 bp from pter      End:
245,872,733 bp from pter
Size:
554,447 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KI26B_HUMAN, Q2KJY2 (See protein sequence)
Recommended Name: Kinesin-like protein KIF26B  
Size: 2108 amino acids; 223883 Da
Subunit: Interacts with MYH10 (By similarity)
Subcellular location: Cytoplasm (By similarity). Cytoplasm, cytoskeleton (Probable)
Sequence caution: Sequence=AAH42481.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
Sequence=BAA91469.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC86076.1;
Type=Miscellaneous discrepancy; Note=Aberrant splicing; Sequence=BAC87614.1; Type=Miscellaneous discrepancy;
Note=Intron retention;
Secondary accessions: Q6ZQR9 Q6ZUZ0 Q8IUN3 Q8IVR1 Q9NWB4
Alternative splicing: 2 isoforms:  Q2KJY2-1   Q2KJY2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KIF26B: NX_Q2KJY2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q2KJY2

  • KIF26B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_060482.2  
    ENSEMBL proteins: 
     ENSP00000385545   ENSP00000355475  

    Human Recombinant Protein Products: 
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    Uscn Proteins for KIF26B

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005874microtubule IEA--
    GO:0005875microtubule associated complex IEA--


    KIF26B for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for KIF26B


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    KIF26B for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001752 Kinesin_motor_dom

    Graphical View of Domain Structure for InterPro Entry Q2KJY2

    ProtoNet protein and cluster: Q2KJY2

    UniProtKB/Swiss-Prot: KI26B_HUMAN, Q2KJY2
    Similarity: Belongs to the kinesin-like protein family. KIF26 subfamily
    Similarity: Contains 1 kinesin-motor domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: KI26B_HUMAN, Q2KJY2
    Function: Essential for embryonic kidney development. Plays an important role in the compact adhesion between
    mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the
    establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains
    the GDNF expression required for further ureteric bud attraction (By similarity)

    miRNA
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    hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-29c hsa-miR-29a hsa-miR-767-5p hsa-miR-302e hsa-miR-511
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003777microtubule motor activity IEA--
    GO:0005524ATP binding IEA--


    KIF26B for ontologies           About GeneDecksing


    Animal Models:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Kif26b):
     mortality/aging  renal/urinary system 

    KIF26B for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIF26B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for KIF26B (Q2KJY23 ENSP000003855454) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP4K4O958193, ENSP000003136444I2D: score=3 STRING: ENSP00000313644
    CDK2ENSP000002669704STRING: ENSP00000266970
    CDK5ENSP000002975184STRING: ENSP00000297518
    CDK6ENSP000002657344STRING: ENSP00000265734
    NEDD4ENSP000003455304STRING: ENSP00000345530
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007018microtubule-based movement IEA--
    GO:0022409positive regulation of cell-cell adhesion IEA--
    GO:0030010establishment of cell polarity IEA--
    GO:0072092ureteric bud invasion IEA--


    KIF26B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KIF26B
    Search CenterWatch for drugs/clinical trials and news about KIF26B / KI26B 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KIF26B gene: 
    NM_018012.3  

    Unigene Cluster for KIF26B:

    Kinesin family member 26B
    Hs.368096  [show with all ESTs]
    Unigene Representative Sequence: AY923834
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000407071(uc010pyq.1 uc001ibh.1 uc001ibf.1) ENST00000479506(uc010pyr.2)
    ENST00000366518(uc001ibg.1) ENST00000483253

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    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate KIF26B (see all 32):
    hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-29c hsa-miR-29a hsa-miR-767-5p hsa-miR-302e hsa-miR-511
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIF26B

    Additional cDNA sequence: 

    AK001019.1 AK125187.1 AK128806.1 AK293964.1 AK297303.1 AY923834.1 BC035896.1 BC042481.1 

    6 DOTS entries:

    DT.205100  DT.40278732  DT.121458844  DT.101963434  DT.95218814  DT.95103809 

    3 AceView cDNA sequences:

    BC035896 BI522408 AK128806 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KIF26B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGCGACAGAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    KIF26B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartEndocardiumCushion Mesenchymal CellsEndocardium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
    PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
    Posterior foregut-like cells (A scalable, suspensi...)

    See KIF26B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KIF26B

    SOURCE GeneReport for Unigene cluster: Hs.368096
        SABiosciences Custom PCR Arrays for KIF26B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF26B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KIF26B gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves LOC1008598131 kinesin-like protein KIF26B-like 75.34(n)
    80.55(a)
      100859813  XM_003640984.1  XP_003641032.1 
    lizard
    (Anolis carolinensis)
    Reptilia KIF26B6
    --
    77(a)
    1 ↔ 1
    GL343285.1(1454323-1700629)
    zebrafish
    (Danio rerio)
    Actinopterygii kif26ba1 kinesin family member 26Ba 64.69(n)
    67.38(a)
      569545  XM_692940.5  XP_698032.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG145356
    --
    24(a)
    possible ortholog
    2L(7844905-7855255)
    worm
    (Caenorhabditis elegans)
    Secernentea vab-86
    Kinesin-like protein vab-8
    21(a)
    possible ortholog
    V(12213308-12225901)


    ENSEMBL Gene Tree for KIF26B (if available)
    TreeFam Gene Tree for KIF26B (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KIF26B gene
    KIF26A2  
    1 SIMAP similar gene for KIF26B using alignment to 2 protein entries:     KI26B_HUMAN (see all proteins):
    KIF26A

    KIF26B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/11798 NCBI SNPs in KIF26B are shown (see all 11798    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs57823581,2
    C,--216150290(+) AAGGG-/AAAAAA 1 -- int1 trp31Minor allele frequency- A:0.00NA 2
    rs769771661,2
    --216150290(+) AAGGGA/GAAAAA 1 -- int10--------
    rs674024201,2
    C--216250527(+) TTCAA-/TTGTC 
            
    TTGTC
    1 -- int10--------
    rs1808475541,2
    --245316435(+) ACTCTG/TGCAGA 1 -- us2k10--------
    rs786679211,2
    F,--245316506(+) GCCCCC/TAGCTA 1 -- us2k12Minor allele frequency- T:0.10NA EA 240
    rs127523311,2
    C,F,A,--245316555(+) TCTCCG/AAGGTG 1 -- us2k111Minor allele frequency- A:0.37NA WA CSA EA 373
    rs2020598271,2
    --245316594(+) CGACA-/CCCCAC 1 -- us2k10--------
    rs727755021,2
    C,--245316755(+) CCTGCC/ACCCTA 1 -- us2k14Minor allele frequency- A:0.35NA WA EA 360
    rs1132747941,2
    C,--245317185(+) GTTAAC/TTAAAG 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1180855161,2
    F,--245317318(+) CTGCGC/TCGGGG 1 -- us2k11Minor allele frequency- T:0.04EA 120

    HapMap Linkage Disequilibrium report for KIF26B (245318287 - 245568287 bp, first 250kb of KIF26B)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 38 variations for KIF26B
         15/19 CNVs (see all 19): 48298 9916 48292 66371 48293 71622 6815 48297 34792 38175 38176 48295 53756 48296 48294
         15/18 Indels (see all 18): 39706 11445 84960 41458 24129 24128 84959 97699 84961 71614 44545 44546 74969 84962 41394
         1 Inversion: 37090

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    KIF26B for disorders           About GeneDecksing

    OMIM gene information: 614026    OMIM disorders: --

    2 diseases for KIF26B:    About MalaCards
    microcephaly    neuronitis

    1 disease from the University of Copenhagen DISEASES database for KIF26B:
    Microcephaly
    Human Genome Epidemiology (HuGE) Navigator: KIF26B (1 document)

    Export disorders for KIF26B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KIF26B gene integrated from 9 sources:
    (articles sorted by number of sources associating them with KIF26B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Phosphorylation of Kif26b promotes its polyubiquitinat ion and subsequent proteasomal degradation during kidney development. (PubMed id 22768111)1 Terabayashi T....Nishinakamura R. (2012)
    3. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)
    8. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55083 HGNC: 25484 AceView: FLJ10157 Ensembl:ENSG00000162849 euGenes: HUgn55083
    ECgene: KIF26B H-InvDB: KIF26B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KIF26B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KIF26B gene:
    Search GeneIP for patents involving KIF26B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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