KIF26B Gene
protein-coding GIFtS : 45
GCID: GC01 P245318
kinesin family member 26B
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Aliasesfor KIF26B gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Kinesin Family Member 26B 1 2 FLJ101571 Kinesin-Like Protein KIF26B2
Export aliases for KIF26B gene to outside databases Previous GC identifers: GC01P243384 GC01P215701
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Summariesfor KIF26B gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: KI26B_HUMAN, Q2KJY2 Function : Essential for embryonic kidney development. Plays an important role in the compact adhesion betweenmesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction (By similarity)
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Genomic Viewsfor KIF26B gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NC_018912.1 NT_167186.1 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the KIF26B gene promoter: HFH-3 LHX3b/Lhx3b RREB-1 Olf-1 FOXI1 MZF-1 S8 SRY LHX3a/Lhx3a Hlf Other transcription factors Search SABiosciences Chromatin IP Primers for KIF26B Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat KIF26B
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1q44 Ensembl cytogenetic band: 1q44 HGNC cytogenetic band: 1q44 KIF26B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01P245318: view genomic region
(about GC identifiers )
Start:
245,318,287 bp from pter
End:
245,872,733 bp from pter
Size:
554,447 bases
Orientation:
plus strand
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Proteinsfor KIF26B gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: KI26B_HUMAN, Q2KJY2 (See
protein sequence )Recommended Name: Kinesin-like protein KIF26B Size : 2108 amino acids; 223883 Da
Subunit : Interacts with MYH10 (By similarity)
Subcellular location : Cytoplasm (By similarity). Cytoplasm, cytoskeleton (Probable)
Sequence caution : Sequence=AAH42481.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;Sequence=BAA91469.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC86076.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing; Sequence=BAC87614.1; Type=Miscellaneous discrepancy; Note=Intron retention;
Secondary accessions : Q6ZQR9 Q6ZUZ0 Q8IUN3 Q8IVR1 Q9NWB4Alternative splicing : 2 isoforms : Q2KJY2-1 Q2KJY2-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for KIF26B: NX_Q2KJY2 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q2KJY2 KIF26B Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_060482.2 ENSEMBL proteins: ENSP00000385545 ENSP00000355475 Human Recombinant Protein Products: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
KIF26B for ontologies About GeneDecksing KIF26B Antibody Products: Assay Products for KIF26B:
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Protein
Domains / Familiesfor KIF26B gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
KIF26B for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q2KJY2 ProtoNet protein and cluster: Q2KJY2
UniProtKB/Swiss-Prot: KI26B_HUMAN, Q2KJY2 Similarity : Belongs to the kinesin-like protein family. KIF26 subfamilySimilarity : Contains 1 kinesin-motor domain
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Functionfor KIF26B gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: KI26B_HUMAN, Q2KJY2 Function : Essential for embryonic kidney development. Plays an important role in the compact adhesion betweenmesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction (By similarity)
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for KIF26B (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for KIF26B (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: KIF26B (NM_018012 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KIF26B Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat KIF26B
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF26B
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003777 microtubule motor activity
IEA -- GO:0005524 ATP binding
IEA --
KIF26B for ontologies About GeneDecksing Animal Models: 2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Kif26b) :
KIF26B for phenotypes About GeneDecksing
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Pathways & Interactionsfor KIF26B gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIF26B STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)5/7 Interacting proteins for KIF26B (Q2KJY2 3 ENSP00000385545 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 7 )About this table Gene Ontology (GO): 4 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0007018 microtubule-based movement
IEA -- GO:0022409 positive regulation of cell-cell adhesion
IEA -- GO:0030010 establishment of cell polarity
IEA -- GO:0072092 ureteric bud invasion
IEA --
KIF26B for ontologies About GeneDecksing
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Drugs & Compoundsfor KIF26B gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for KIF26B Search CenterWatch for drugs/clinical trials and news about KIF26B / KI26B
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Transcriptsfor KIF26B gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for KIF26B gene: NM_018012.3 Unigene Cluster for KIF26B:
Kinesin family member 26B Hs.368096 [show with all ESTs ] Unigene Representative Sequence: AY923834 4 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000407071 (uc010pyq.1 uc001ibh.1 uc001ibf.1 ) ENST00000479506 (uc010pyr.2 )ENST00000366518 (uc001ibg.1 ) ENST00000483253 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for KIF26B (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for KIF26B (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: KIF26B (NM_018012 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KIF26B Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat KIF26B
Additional cDNA sequence: AK001019.1 AK125187.1 AK128806.1 AK293964.1 AK297303.1 AY923834.1 BC035896.1 BC042481.1
6 DOTS entries : DT.205100 DT.40278732
DT.121458844 DT.101963434 DT.95218814 DT.95103809 3 AceView cDNA sequences :
BC035896 BI522408 AK128806 GeneLoc Exon Structure
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Expression for KIF26B gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section KIF26B expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GGCGACAGAA
About this image KIF26B expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See KIF26B Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for KIF26B SOURCE GeneReport for Unigene cluster: Hs.368096 SABiosciences Custom PCR Arrays for KIF26B Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for KIF26BBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat KIF26B QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat KIF26B QIAGEN QuantiFast Probe-based Assays in human , mouse , rat KIF26B In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF26B
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Orthologsfor KIF26B gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for KIF26B gene from 5/18 species (see all 18 ) About this table
ENSEMBL Gene Tree for KIF26B (if available)TreeFam Gene Tree for KIF26B (if available)
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Paralogsfor KIF26B gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for KIF26B gene KIF26A 2 1 SIMAP similar gene for KIF26B using alignment to 2 protein entries: KI26B_HUMAN (see all proteins ):KIF26A
KIF26B for paralogs About GeneDecksing
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Genomic Variantsfor KIF26B gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 1 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for KIF26B (245318287 - 245568287 bp, first 250kb of KIF26B)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 38 variations for KIF26B 15/19 CNVs (see all 19 ): 48298 9916 48292 66371 48293 71622 6815 48297 34792 38175 38176 48295 53756 48296 48294 15/18 Indels (see all 18 ): 39706 11445 84960 41458 24129 24128 84959 97699 84961 71614 44545 44546 74969 84962 41394 1 Inversion : 37090
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing KIF26B
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Disorders
/ Diseasesfor KIF26B gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
KIF26B for disorders About GeneDecksing
OMIM gene information: 614026
OMIM disorders : --2 diseases for KIF26B : About MalaCards microcephaly neuronitis 1 disease from the University of Copenhagen DISEASES database for KIF26B :Microcephaly Human Genome Epidemiology (HuGE) Navigator: KIF26B (1 document)Export disorders for KIF26B gene to outside databases
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Publicationsfor KIF26B gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for KIF26B gene integrated from 9 sources : (articles sorted by number of sources associating them with KIF26B) Utopia : connect your pdf to the dynamic world of online information
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Phosphorylation of Kif26b promotes its polyubiquitinat ion and subsequent proteasomal degradation during kidney development. (PubMed id 22768111) 1 Terabayashi T....Nishinakamura R. (2012) A human MAP kinase interactome. (PubMed id 20936779) 1 Bandyopadhyay S....Ideker T. (2010) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) The sequence of the human genome. (PubMed id 11181995) 1 Venter J.C.... Zhu X. (2001) Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id ) 2 Aoki H.... Hino O. (2000)
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External Searches for KIF26B gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing KIF26B gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing KIF26B gene
(According to HUGE )
About This Section --
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Specialized Databases showing KIF26B gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for KIF26B Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for KIF26B gene: Search GeneIP for patents involving KIF26B GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor KIF26B gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for KIF26B OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for KIF26B OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for KIF26B Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for KIF26B OriGene 3'-UTR Clone for KIF26B OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for KIF26B OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for KIF26B Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KIF26B QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing KIF26B QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat KIF26B QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat KIF26B QIAGEN QuantiFast Probe-based Assays in human , mouse , rat KIF26B QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat KIF26B
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KIF26B Proteins, Antibodies, CLIAs, and ELISAs
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